Entry name	Average score	Number of operons	Number of MIBiG operons	Number of operons with antismash overlap	Nr of operons with known RiPP domains	Average COG score	Nr of operons passed filter	Common domains
precursor_groups_2166	30.46 +- 5.65	2	0	0	0	0.07 +- 0.12	2	6 PF17853 (2/2) GGDEF-like domain PF14333 (2/2) Domain of unknown function (DUF4389) PF13556 (2/2) PucR C-terminal helix-turn-helix domain PF08448 (2/2) PAS fold PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF03492 (2/2) SAM dependent carboxyl methyltransferase
precursor_groups_906	57.96 +- 12.04	2	0	0	2	0.05 +- 0.10	2	9 TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family TIGR04268 (2/2) FXSXX-COOH protein TIGR04267 (2/2) HEXXH motif domain PF13676 (2/2) TIR domain PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF07728 (2/2) AAA domain (dynein-related subfamily) PF04055 (2/2) Radical SAM superfamily
precursor_groups_239	614.62 +- 470.04	25	0	21	0	0.07 +- 0.11	25	26 TIGR01525 (25/25) heavy metal translocating P-type ATPase PF04314 (25/25) Copper chaperone PCu(A)C PF00702 (25/25) haloacid dehalogenase-like hydrolase PF00403 (25/25) Heavy-metal-associated domain PF00122 (25/25) E1-E2 ATPase PF07690 (23/25) Major Facilitator Superfamily PF05118 (21/25) Aspartyl/Asparaginyl beta-hydroxylase TIGR01733 (19/25) amino acid adenylation domain PF13193 (19/25) AMP-binding enzyme C-terminal domain PF10862 (19/25) FcoT-like thioesterase domain PF08545 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (19/25) Male sterility protein PF02668 (19/25) Taurine catabolism dioxygenase TauD, TfdA family PF00668 (19/25) Condensation domain PF00550 (19/25) Phosphopantetheine attachment site PF00501 (19/25) AMP-binding enzyme TIGR01746 (18/25) thioester reductase domain TIGR00747 (18/25) 3-oxoacyl-[acyl-carrier-protein] synthase III PF01497 (18/25) Periplasmic binding protein PF01032 (18/25) FecCD transport family PF00005 (18/25) ABC transporter PF01965 (17/25) DJ-1/PfpI family TIGR02937 (16/25) RNA polymerase sigma factor, sigma-70 family PF08281 (16/25) Sigma-70, region 4 PF04542 (16/25) Sigma-70 region 2
precursor_groups_33088	240.43 +- 106.11	3	0	3	0	0.01 +- 0.02	3	4 TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme PF01266 (3/3) FAD dependent oxidoreductase PF01019 (3/3) Gamma-glutamyltranspeptidase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_groups_8175	554.81 +- 177.49	10	0	0	0	0.02 +- 0.02	10	19 TIGR02124 (10/10) hydrogenase expression/formation protein HypE TIGR01891 (10/10) amidohydrolase TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase TIGR00143 (10/10) carbamoyltransferase HypF PF17788 (10/10) HypF Kae1-like domain PF13535 (10/10) ATP-grasp domain PF12680 (10/10) SnoaL-like domain PF07690 (10/10) Major Facilitator Superfamily PF07503 (10/10) HypF finger PF05977 (10/10) Transmembrane secretion effector PF02769 (10/10) AIR synthase related protein, C-terminal domain PF01546 (10/10) Peptidase family M20/M25/M40 PF01300 (10/10) Telomere recombination PF00857 (10/10) Isochorismatase family PF00708 (10/10) Acylphosphatase PF00586 (10/10) AIR synthase related protein, N-terminal domain PF00202 (10/10) Aminotransferase class-III PF00155 (10/10) Aminotransferase class I and II PF00583 (9/10) Acetyltransferase (GNAT) family
precursor_groups_8171	414.92 +- 442.96	5	0	0	0	0.06 +- 0.12	5	7 PF13407 (5/5) Periplasmic binding protein domain PF13377 (5/5) Periplasmic binding protein-like domain PF02653 (5/5) Branched-chain amino acid transport system / permease component PF00356 (5/5) Bacterial regulatory proteins, lacI family PF00294 (5/5) pfkB family carbohydrate kinase PF00005 (5/5) ABC transporter PF05025 (4/5) RbsD / FucU transport protein family
precursor_groups_25857	1556.00 +- 516.03	4	0	0	0	0.01 +- 0.00	4	7 PF08386 (4/4) TAP-like protein PF07702 (4/4) UTRA domain PF01380 (4/4) SIS domain PF00561 (4/4) alpha/beta hydrolase fold PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00294 (4/4) pfkB family carbohydrate kinase PF00196 (4/4) Bacterial regulatory proteins, luxR family
precursor_groups_48679	277.22 +- 74.60	2	0	0	0	0.08 +- 0.08	2	22 TIGR01733 (2/2) amino acid adenylation domain PF18029 (2/2) Glyoxalase-like domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08713 (2/2) DNA alkylation repair enzyme PF08659 (2/2) KR domain PF07690 (2/2) Major Facilitator Superfamily PF07478 (2/2) D-ala D-ala ligase C-terminus PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01820 (2/2) D-ala D-ala ligase N-terminus PF01494 (2/2) FAD binding domain PF00975 (2/2) Thioesterase domain PF00850 (2/2) Histone deacetylase domain PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00698 (2/2) Acyl transferase domain PF00551 (2/2) Formyl transferase PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00355 (2/2) Rieske [2Fe-2S] domain PF00155 (2/2) Aminotransferase class I and II PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_4581	280.13 +- 235.87	2	0	0	2	0.05 +- 0.16	2	7 PF14518 (2/2) Iron-containing redox enzyme PF12704 (2/2) MacB-like periplasmic core domain PF04055 (2/2) Radical SAM superfamily PF03704 (2/2) Bacterial transcriptional activator domain PF02687 (2/2) FtsX-like permease family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_groups_1662	839.58 +- 460.42	22	20	2	22	0.02 +- 0.02	2	11 TIGR03891 (22/22) thiopeptide-type bacteriocin biosynthesis domain PF14028 (22/22) Lantibiotic biosynthesis dehydratase C-term PF05147 (22/22) Lanthionine synthetase C-like protein PF04738 (22/22) Lantibiotic dehydratase, N terminus PF00005 (22/22) ABC transporter TIGR03731 (21/22) lantibiotic, gallidermin/nisin family PF02052 (18/22) Gallidermin PF00486 (14/22) Transcriptional regulatory protein, C terminal PF02518 (12/22) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00512 (12/22) His Kinase A (phospho-acceptor) domain PF00072 (12/22) Response regulator receiver domain
precursor_groups_41765	760.47 +- 374.44	3	0	0	0	0.04 +- 0.12	3	26 TIGR03567 (3/3) FMN reductase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain PF14559 (3/3) Tetratricopeptide repeat PF13535 (3/3) ATP-grasp domain PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring) PF13432 (3/3) Tetratricopeptide repeat PF13424 (3/3) Tetratricopeptide repeat PF07690 (3/3) Major Facilitator Superfamily PF03358 (3/3) NADPH-dependent FMN reductase PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF01613 (3/3) Flavin reductase like domain PF00326 (3/3) Prolyl oligopeptidase family PF00294 (3/3) pfkB family carbohydrate kinase TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family PF09334 (2/3) tRNA synthetases class I (M) PF08281 (2/3) Sigma-70, region 4 PF07883 (2/3) Cupin domain PF04542 (2/3) Sigma-70 region 2 PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02142 (2/3) MGS-like domain PF01808 (2/3) AICARFT/IMPCHase bienzyme PF00709 (2/3) Adenylosuccinate synthetase PF00355 (2/3) Rieske [2Fe-2S] domain PF00202 (2/3) Aminotransferase class-III
precursor_groups_31630	43.41 +- 0.41	2	0	2	0	0.07 +- 0.09	2	5 PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family PF07690 (2/2) Major Facilitator Superfamily PF00905 (2/2) Penicillin binding protein transpeptidase domain PF00266 (2/2) Aminotransferase class-V PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_81410	1580.73 +- 635.73	2	0	2	0	0.02 +- 0.04	2	14 PF13649 (2/2) Methyltransferase domain PF05193 (2/2) Peptidase M16 inactive domain PF03965 (2/2) Penicillinase repressor PF01937 (2/2) Protein of unknown function DUF89 PF01475 (2/2) Ferric uptake regulator family PF01435 (2/2) Peptidase family M48 PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01061 (2/2) ABC-2 type transporter PF00675 (2/2) Insulinase (Peptidase family M16) PF00583 (2/2) Acetyltransferase (GNAT) family PF00391 (2/2) PEP-utilising enzyme, mobile domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1) PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter
precursor_groups_60000	182.05 +- 34.62	2	0	0	0	0.02 +- 0.02	2	6 TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family PF17148 (2/2) Domain of unknown function (DUF5117) PF16313 (2/2) Met-zincin PF07702 (2/2) UTRA domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_7743	516.00 +- 0.00	2	0	2	2	0.01 +- 0.00	2	7 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03558 (2/2) luciferase family oxidoreductase, group 1 PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF05147 (2/2) Lanthionine synthetase C-like protein PF04738 (2/2) Lantibiotic dehydratase, N terminus PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter
precursor_groups_20892	133.48 +- 31.64	2	0	0	0	0.04 +- 0.04	2	6 PF13649 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF02899 (2/2) Phage integrase, N-terminal SAM-like domain PF01636 (2/2) Phosphotransferase enzyme family PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00293 (2/2) NUDIX domain
precursor_groups_23858	419.05 +- 139.95	3	0	0	0	0.01 +- 0.00	3	9 PF17853 (3/3) GGDEF-like domain PF13556 (3/3) PucR C-terminal helix-turn-helix domain PF12450 (3/3) von Willebrand factor PF12034 (3/3) Domain of unknown function (DUF3520) PF08592 (3/3) Domain of unknown function (DUF1772) PF03704 (3/3) Bacterial transcriptional activator domain PF00486 (3/3) Transcriptional regulatory protein, C terminal PF00092 (3/3) von Willebrand factor type A domain PF01590 (2/3) GAF domain
precursor_groups_4514	1001.47 +- 887.78	16	0	12	0	0.05 +- 0.18	16	18 PF13535 (16/16) ATP-grasp domain PF13480 (16/16) Acetyltransferase (GNAT) domain PF13115 (16/16) YtkA-like PF04389 (16/16) Peptidase family M28 PF02627 (16/16) Carboxymuconolactone decarboxylase family PF00664 (16/16) ABC transporter transmembrane region PF00403 (16/16) Heavy-metal-associated domain PF00155 (16/16) Aminotransferase class I and II PF00005 (16/16) ABC transporter TIGR01525 (15/16) heavy metal translocating P-type ATPase TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF13549 (15/16) ATP-grasp domain PF01676 (15/16) Metalloenzyme superfamily PF00702 (15/16) haloacid dehalogenase-like hydrolase PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00122 (15/16) E1-E2 ATPase PF00117 (15/16) Glutamine amidotransferase class-I TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
precursor_groups_19376	140.89 +- 0.00	2	0	2	2	0.10 +- 0.08	2	12 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (2/2) SagB-type dehydrogenase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00931 (2/2) NB-ARC domain PF00881 (2/2) Nitroreductase family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_groups_44607	275.37 +- 49.63	2	0	0	0	0.02 +- 0.02	2	8 TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16884 (2/2) N-terminal domain of oxidoreductase PF12146 (2/2) Serine aminopeptidase, S33 PF07690 (2/2) Major Facilitator Superfamily PF06441 (2/2) Epoxide hydrolase N terminus PF00561 (2/2) alpha/beta hydrolase fold PF00107 (2/2) Zinc-binding dehydrogenase PF00106 (2/2) short chain dehydrogenase
precursor_groups_46039	398.33 +- 178.68	3	0	0	0	0.02 +- 0.01	3	8 PF12697 (3/3) Alpha/beta hydrolase family PF11723 (3/3) Homotrimeric ring hydroxylase PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase PF01546 (3/3) Peptidase family M20/M25/M40 PF00561 (3/3) alpha/beta hydrolase fold PF00355 (3/3) Rieske [2Fe-2S] domain PF00175 (3/3) Oxidoreductase NAD-binding domain PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_6399	79.05 +- 17.93	5	0	0	0	0.08 +- 0.03	5	9 TIGR02133 (5/5) ribose 5-phosphate isomerase PF16896 (5/5) Phosphogluconate dehydrogenase (decarboxylating) C-term PF07690 (5/5) Major Facilitator Superfamily PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent PF02734 (5/5) DAK2 domain PF02733 (5/5) Dak1 domain PF02502 (5/5) Ribose/Galactose Isomerase PF01261 (5/5) Xylose isomerase-like TIM barrel PF00121 (5/5) Triosephosphate isomerase
precursor_groups_9254	120.00 +- 0.00	2	0	0	0	0.10 +- 0.25	2	12 TIGR00229 (2/2) PAS domain S-box protein PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796) PF03098 (2/2) Animal haem peroxidase PF02585 (2/2) GlcNAc-PI de-N-acetylase PF01061 (2/2) ABC-2 type transporter PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00582 (2/2) Universal stress protein family PF00199 (2/2) Catalase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF08448 (1/2) PAS fold PF00989 (1/2) PAS fold
precursor_groups_62683	3194.97 +- 210.63	2	0	0	0	0.02 +- 0.01	2	13 TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (2/2) ATP-grasp domain PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (2/2) Prephenate dehydrogenase PF01613 (2/2) Flavin reductase like domain PF01070 (2/2) FMN-dependent dehydrogenase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (2/2) Luciferase-like monooxygenase PF00155 (2/2) Aminotransferase class I and II PF00106 (2/2) short chain dehydrogenase
precursor_groups_19562	118.50 +- 53.50	2	0	0	0	0.05 +- 0.07	2	14 PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096) PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin PF12770 (2/2) CHAT domain PF07510 (2/2) Protein of unknown function (DUF1524) PF03235 (2/2) Protein of unknown function DUF262 PF01609 (2/2) Transposase DDE domain PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain PF17908 (1/2) APAF-1 helical domain PF13586 (1/2) Transposase DDE domain PF04555 (1/2) Restriction endonuclease XhoI PF01937 (1/2) Protein of unknown function DUF89 PF01636 (1/2) Phosphotransferase enzyme family PF00931 (1/2) NB-ARC domain PF00400 (1/2) WD domain, G-beta repeat
precursor_groups_2	284.40 +- 250.53	6	0	5	1	0.05 +- 0.12	6	25 PF04149 (5/6) Domain of unknown function (DUF397) TIGR01762 (4/6) chlorinating enzyme TIGR01733 (4/6) amino acid adenylation domain TIGR01509 (4/6) HAD hydrolase, family IA, variant 3 TIGR01444 (4/6) methyltransferase, FkbM family TIGR00843 (4/6) benzoate transporter PF16990 (4/6) Carbohydrate binding module (family 35) PF13560 (4/6) Helix-turn-helix domain PF13535 (4/6) ATP-grasp domain PF13454 (4/6) FAD-NAD(P)-binding PF13419 (4/6) Haloacid dehalogenase-like hydrolase PF13193 (4/6) AMP-binding enzyme C-terminal domain PF07691 (4/6) PA14 domain PF06439 (4/6) Domain of Unknown Function (DUF1080) PF05721 (4/6) Phytanoyl-CoA dioxygenase (PhyH) PF05050 (4/6) Methyltransferase FkbM domain PF03594 (4/6) Benzoate membrane transport protein PF02771 (4/6) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (4/6) Acyl-CoA dehydrogenase, middle domain PF01116 (4/6) Fructose-bisphosphate aldolase class-II PF00975 (4/6) Thioesterase domain PF00892 (4/6) EamA-like transporter family PF00550 (4/6) Phosphopantetheine attachment site PF00501 (4/6) AMP-binding enzyme PF00441 (4/6) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_1	922.65 +- 1480.94	16	0	5	5	0.03 +- 0.05	16	2 PF04149 (16/16) Domain of unknown function (DUF397) PF13560 (8/16) Helix-turn-helix domain
precursor_groups_6306	257.74 +- 131.52	2	0	0	0	0.02 +- 0.10	2	15 TIGR01554 (2/2) phage major capsid protein, HK97 family TIGR01543 (2/2) phage prohead protease, HK97 family TIGR01537 (2/2) phage portal protein, HK97 family PF05065 (2/2) Phage capsid family PF04860 (2/2) Phage portal protein PF04586 (2/2) Caudovirus prohead serine protease PF01844 (2/2) HNH endonuclease PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase TIGR00621 (1/2) single-stranded DNA-binding protein PF13560 (1/2) Helix-turn-helix domain PF13481 (1/2) AAA domain PF12728 (1/2) Helix-turn-helix domain PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal PF01580 (1/2) FtsK/SpoIIIE family PF00436 (1/2) Single-strand binding protein family
precursor_groups_4	121.60 +- 155.04	4	0	0	0	0.05 +- 0.09	4	6 TIGR01509 (3/4) HAD hydrolase, family IA, variant 3 PF13419 (3/4) Haloacid dehalogenase-like hydrolase PF08386 (3/4) TAP-like protein PF04149 (3/4) Domain of unknown function (DUF397) PF02388 (3/4) FemAB family PF00561 (3/4) alpha/beta hydrolase fold
precursor_groups_353	456.93 +- 108.77	3	0	3	0	0.03 +- 0.03	3	6 TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor PF13193 (3/3) AMP-binding enzyme C-terminal domain PF00501 (3/3) AMP-binding enzyme PF01959 (2/3) 3-dehydroquinate synthase II PF01791 (2/3) DeoC/LacD family aldolase PF01494 (2/3) FAD binding domain
precursor_groups_11212	795.64 +- 536.08	8	0	8	8	0.03 +- 0.08	8	12 TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (8/8) SagB-type dehydrogenase domain TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component PF13575 (8/8) Domain of unknown function (DUF4135) PF03412 (8/8) Peptidase C39 family PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (8/8) Nitroreductase family PF00664 (8/8) ABC transporter transmembrane region PF00067 (8/8) Cytochrome P450 PF00005 (8/8) ABC transporter PF00364 (6/8) Biotin-requiring enzyme PF05147 (4/8) Lanthionine synthetase C-like protein
precursor_groups_31252	1255.97 +- 999.97	4	0	4	0	0.03 +- 0.06	4	33 TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (4/4) amino acid adenylation domain TIGR00976 (4/4) hydrolase CocE/NonD family protein PF16197 (4/4) Ketoacyl-synthetase C-terminal extension PF13193 (4/4) AMP-binding enzyme C-terminal domain PF13187 (4/4) 4Fe-4S dicluster domain PF08659 (4/4) KR domain PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07690 (4/4) Major Facilitator Superfamily PF07228 (4/4) Stage II sporulation protein E (SpoIIE) PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family) PF01070 (4/4) FMN-dependent dehydrogenase PF00698 (4/4) Acyl transferase domain PF00668 (4/4) Condensation domain PF00583 (4/4) Acetyltransferase (GNAT) family PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00296 (4/4) Luciferase-like monooxygenase PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00202 (4/4) Aminotransferase class-III PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain PF13459 (3/4) 4Fe-4S single cluster domain PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF09335 (3/4) SNARE associated Golgi protein PF07730 (3/4) Histidine kinase PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00196 (3/4) Bacterial regulatory proteins, luxR family PF00072 (3/4) Response regulator receiver domain
precursor_groups_3707	1270.23 +- 755.78	18	2	16	18	0.02 +- 0.03	16	8 TIGR03897 (18/18) type 2 lantibiotic biosynthesis protein LanM PF13575 (18/18) Domain of unknown function (DUF4135) PF05147 (18/18) Lanthionine synthetase C-like protein PF03412 (18/18) Peptidase C39 family PF00664 (18/18) ABC transporter transmembrane region PF00005 (18/18) ABC transporter PF14867 (16/18) Lantibiotic alpha PF12730 (15/18) ABC-2 family transporter protein
precursor_groups_46517	138.46 +- 43.67	3	0	0	0	0.03 +- 0.02	3	9 PF17291 (3/3) N-terminal domain of M60-like peptidases PF13402 (3/3) Peptidase M60, enhancin and enhancin-like PF13377 (3/3) Periplasmic binding protein-like domain PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264) PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_41235	63.35 +- 11.31	3	0	0	0	0.05 +- 0.03	3	4 PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase PF07702 (3/3) UTRA domain PF01925 (3/3) Sulfite exporter TauE/SafE PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_groups_17587	116.33 +- 25.07	6	0	6	6	0.04 +- 0.04	6	4 TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase PF16715 (6/6) Cyclodipeptide synthase PF00881 (6/6) Nitroreductase family PF00089 (6/6) Trypsin
precursor_groups_121	1363.95 +- 1630.95	4	0	4	4	0.04 +- 0.08	4	14 TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term PF04738 (4/4) Lantibiotic dehydratase, N terminus PF03704 (4/4) Bacterial transcriptional activator domain PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (4/4) ABC-2 type transporter PF00881 (4/4) Nitroreductase family PF00486 (4/4) Transcriptional regulatory protein, C terminal PF00005 (4/4) ABC transporter TIGR03892 (3/4) thiazolylpeptide-type bacteriocin precursor TIGR01891 (3/4) amidohydrolase PF01546 (3/4) Peptidase family M20/M25/M40 PF00296 (2/4) Luciferase-like monooxygenase
precursor_groups_34009	377.27 +- 142.73	2	0	0	0	0.02 +- 0.01	2	9 TIGR03930 (2/2) WXG100 family type VII secretion target TIGR03920 (2/2) type VII secretion integral membrane protein EccD TIGR03919 (2/2) type VII secretion protein EccB PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD PF07202 (2/2) T-complex protein 10 C-terminus PF06013 (2/2) Proteins of 100 residues with WXG PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B PF02575 (2/2) YbaB/EbfC DNA-binding family PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_groups_21556	832.00 +- 254.75	5	0	0	5	0.01 +- 0.00	5	3 PF07690 (5/5) Major Facilitator Superfamily PF04055 (5/5) Radical SAM superfamily PF02441 (5/5) Flavoprotein
precursor_groups_18390	864.29 +- 155.78	3	0	3	3	0.01 +- 0.02	3	9 TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (3/3) Iron-sulfur cluster-binding domain PF08241 (3/3) Methyltransferase domain PF07690 (3/3) Major Facilitator Superfamily PF04055 (3/3) Radical SAM superfamily PF01980 (3/3) tRNA-methyltransferase O PF01494 (3/3) FAD binding domain PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_groups_44042	47.53 +- 2.00	2	0	0	0	0.06 +- 0.06	2	3 PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
precursor_groups_71616	195.00 +- 0.00	2	0	1	0	0.02 +- 0.00	2	10 TIGR00229 (2/2) PAS domain S-box protein PF17148 (2/2) Domain of unknown function (DUF5117) PF16313 (2/2) Met-zincin PF13581 (2/2) Histidine kinase-like ATPase domain PF13426 (2/2) PAS domain PF13185 (2/2) GAF domain PF08448 (2/2) PAS fold PF07702 (2/2) UTRA domain PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_61212	101.28 +- 23.28	2	0	0	2	0.05 +- 0.10	2	8 PF13581 (2/2) Histidine kinase-like ATPase domain PF13191 (2/2) AAA ATPase domain PF09346 (2/2) SMI1 / KNR4 family (SUKH-1) PF05147 (2/2) Lanthionine synthetase C-like protein PF00561 (2/2) alpha/beta hydrolase fold PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF04978 (1/2) Protein of unknown function (DUF664)
precursor_groups_3209	61.10 +- 12.21	3	0	1	0	0.05 +- 0.02	3	3 PF01292 (3/3) Prokaryotic cytochrome b561 PF00174 (3/3) Oxidoreductase molybdopterin binding domain PF07519 (2/3) Tannase and feruloyl esterase
precursor_groups_55307	481.90 +- 168.10	2	0	0	0	0.02 +- 0.02	2	6 PF13377 (2/2) Periplasmic binding protein-like domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family PF00266 (2/2) Aminotransferase class-V
precursor_groups_83750	705.83 +- 204.17	2	0	0	0	0.01 +- 0.01	2	7 PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain PF17754 (2/2) MftR C-terminal domain PF13460 (2/2) NAD(P)H-binding PF04075 (2/2) F420H(2)-dependent quinone reductase PF01418 (2/2) Helix-turn-helix domain, rpiR family PF01380 (2/2) SIS domain PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_groups_41801	344.00 +- 86.00	2	0	0	0	0.01 +- 0.01	2	7 TIGR03696 (2/2) RHS repeat-associated core domain TIGR01643 (2/2) YD repeat (two copies) PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF13424 (2/2) Tetratricopeptide repeat PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic PF05593 (2/2) RHS Repeat PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_36866	332.14 +- 118.84	3	0	0	0	0.02 +- 0.01	3	3 PF07690 (3/3) Major Facilitator Superfamily PF00884 (3/3) Sulfatase PF12697 (2/3) Alpha/beta hydrolase family
precursor_groups_545	287.08 +- 232.92	2	0	2	2	0.04 +- 0.10	2	7 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF07730 (2/2) Histidine kinase PF06722 (2/2) Protein of unknown function (DUF1205) PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00072 (2/2) Response regulator receiver domain
precursor_groups_542	156.12 +- 66.54	2	0	1	0	0.07 +- 0.06	2	10 TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence PF17900 (1/2) Peptidase M1 N-terminal domain PF03814 (1/2) Potassium-transporting ATPase A subunit PF01547 (1/2) Bacterial extracellular solute-binding protein PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF01433 (1/2) Peptidase family M1 domain PF00583 (1/2) Acetyltransferase (GNAT) family PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00331 (1/2) Glycosyl hydrolase family 10 PF00293 (1/2) NUDIX domain
precursor_groups_11589	780.00 +- 260.00	6	0	0	6	0.01 +- 0.00	6	4 PF07690 (6/6) Major Facilitator Superfamily PF04055 (6/6) Radical SAM superfamily PF02441 (6/6) Flavoprotein PF02310 (3/6) B12 binding domain
precursor_groups_11233	4608.81 +- 2021.19	2	0	2	0	0.02 +- 0.03	2	16 PF17914 (2/2) HopA1 effector protein family PF13649 (2/2) Methyltransferase domain PF11468 (2/2) Aromatic prenyltransferase Orf2 PF05193 (2/2) Peptidase M16 inactive domain PF02441 (2/2) Flavoprotein PF01527 (2/2) Transposase PF01061 (2/2) ABC-2 type transporter PF00675 (2/2) Insulinase (Peptidase family M16) PF00664 (2/2) ABC transporter transmembrane region PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter PF13847 (1/2) Methyltransferase domain PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF13489 (1/2) Methyltransferase domain PF00183 (1/2) Hsp90 protein PF00069 (1/2) Protein kinase domain
precursor_groups_104	219.64 +- 53.64	11	0	0	0	0.04 +- 0.06	11	3 PF13545 (9/11) Crp-like helix-turn-helix domain PF07228 (9/11) Stage II sporulation protein E (SpoIIE) PF00027 (9/11) Cyclic nucleotide-binding domain
precursor_groups_4868	229.23 +- 30.77	3	1	1	0	0.01 +- 0.01	2	4 PF03412 (3/3) Peptidase C39 family PF00664 (3/3) ABC transporter transmembrane region PF00005 (3/3) ABC transporter PF00535 (2/3) Glycosyl transferase family 2
precursor_groups_17449	216.17 +- 107.83	2	0	0	0	0.04 +- 0.05	2	9 TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family TIGR01979 (2/2) cysteine desulfurase, SufS family PF16868 (2/2) NMT1-like family PF05977 (2/2) Transmembrane secretion effector PF04185 (2/2) Phosphoesterase family PF00266 (2/2) Aminotransferase class-V PF00027 (2/2) Cyclic nucleotide-binding domain TIGR01167 (1/2) LPXTG cell wall anchor domain PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_groups_68315	1554.00 +- 6.00	2	0	2	0	0.01 +- 0.00	2	7 PF08007 (2/2) Cupin superfamily protein PF03412 (2/2) Peptidase C39 family PF00668 (2/2) Condensation domain PF00664 (2/2) ABC transporter transmembrane region PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00005 (2/2) ABC transporter
precursor_groups_70666	85.00 +- 45.00	2	0	0	0	0.03 +- 0.03	2	2 PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase PF00775 (2/2) Dioxygenase
precursor_groups_23434	338.00 +- 182.00	2	0	0	0	0.02 +- 0.06	2	10 PF07291 (2/2) Methylamine utilisation protein MauE PF00717 (2/2) Peptidase S24-like PF00005 (2/2) ABC transporter TIGR00546 (1/2) apolipoprotein N-acyltransferase PF10502 (1/2) Signal peptidase, peptidase S26 PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain PF01494 (1/2) FAD binding domain PF00795 (1/2) Carbon-nitrogen hydrolase PF00578 (1/2) AhpC/TSA family PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_11906	183.10 +- 82.91	6	0	0	0	0.01 +- 0.01	6	1 PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
precursor_groups_78352	259.00 +- 1.00	2	0	0	0	0.01 +- 0.00	2	3 PF07859 (2/2) alpha/beta hydrolase fold PF00175 (2/2) Oxidoreductase NAD-binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_20733	765.63 +- 127.45	2	0	1	0	0.01 +- 0.01	2	8 PF11953 (2/2) Domain of unknown function (DUF3470) PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02597 (2/2) ThiS family PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00037 (2/2) 4Fe-4S binding domain PF00550 (1/2) Phosphopantetheine attachment site
precursor_groups_77605	230.67 +- 116.00	2	0	0	0	0.02 +- 0.03	2	6 PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_35663	122.11 +- 15.00	3	0	1	0	0.08 +- 0.21	3	9 PF13191 (3/3) AAA ATPase domain PF10502 (3/3) Signal peptidase, peptidase S26 PF07291 (3/3) Methylamine utilisation protein MauE PF02254 (3/3) TrkA-N domain PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase PF00717 (3/3) Peptidase S24-like PF00664 (3/3) ABC transporter transmembrane region PF00005 (3/3) ABC transporter PF13181 (2/3) Tetratricopeptide repeat
precursor_groups_15437	282.51 +- 110.62	6	0	0	0	0.01 +- 0.01	6	5 TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain PF07963 (6/6) Prokaryotic N-terminal methylation motif PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain PF03551 (6/6) Transcriptional regulator PadR-like family PF01478 (6/6) Type IV leader peptidase family
precursor_groups_2281	800.06 +- 256.65	6	0	5	0	0.01 +- 0.01	6	11 PF17914 (6/6) HopA1 effector protein family PF05193 (6/6) Peptidase M16 inactive domain PF01636 (6/6) Phosphotransferase enzyme family PF00675 (6/6) Insulinase (Peptidase family M16) PF13649 (5/6) Methyltransferase domain PF13546 (5/6) DDE superfamily endonuclease PF02441 (5/6) Flavoprotein PF00005 (5/6) ABC transporter TIGR00414 (3/6) serine--tRNA ligase PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)
precursor_groups_10508	299.00 +- 23.50	2	0	0	0	0.05 +- 0.09	2	12 TIGR01764 (2/2) DNA binding domain, excisionase family PF13411 (2/2) MerR HTH family regulatory protein PF13245 (2/2) AAA domain PF12728 (2/2) Helix-turn-helix domain PF12697 (2/2) Alpha/beta hydrolase family PF12679 (2/2) ABC-2 family transporter protein PF07739 (2/2) TipAS antibiotic-recognition domain PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF01551 (2/2) Peptidase family M23 PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00005 (2/2) ABC transporter PF13673 (1/2) Acetyltransferase (GNAT) domain
precursor_groups_5419	953.88 +- 214.88	4	0	0	4	0.01 +- 0.01	4	7 TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (4/4) Iron-sulfur cluster-binding domain PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (4/4) Radical SAM superfamily PF01061 (4/4) ABC-2 type transporter PF00717 (4/4) Peptidase S24-like PF00005 (4/4) ABC transporter
precursor_groups_23648	167.66 +- 10.77	2	0	0	0	0.06 +- 0.03	2	9 TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein PF13416 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF01593 (2/2) Flavin containing amine oxidoreductase PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00355 (2/2) Rieske [2Fe-2S] domain PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter
precursor_groups_765	190.01 +- 103.85	17	0	17	16	0.04 +- 0.06	17	5 TIGR03975 (17/17) ribosomal peptide maturation radical SAM protein 1 PF07690 (17/17) Major Facilitator Superfamily PF02310 (17/17) B12 binding domain PF00326 (17/17) Prolyl oligopeptidase family PF04055 (16/17) Radical SAM superfamily
precursor_groups_75057	2220.43 +- 119.57	2	0	0	0	0.01 +- 0.00	2	8 PF14081 (2/2) Domain of unknown function (DUF4262) PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like PF08666 (2/2) SAF domain PF07811 (2/2) TadE-like protein PF01476 (2/2) LysM domain PF01381 (2/2) Helix-turn-helix PF00482 (2/2) Type II secretion system (T2SS), protein F PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_1137	203.30 +- 256.64	4	0	0	0	0.04 +- 0.05	4	2 TIGR03296 (4/4) M6 family metalloprotease domain PF01070 (2/4) FMN-dependent dehydrogenase
precursor_groups_45170	1548.00 +- 0.00	2	0	0	2	0.01 +- 0.00	2	17 TIGR01549 (2/2) HAD hydrolase, family IA, variant 1 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF13242 (2/2) HAD-hyrolase-like PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12833 (2/2) Helix-turn-helix domain PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF04055 (2/2) Radical SAM superfamily PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain PF02811 (2/2) PHP domain PF02310 (2/2) B12 binding domain PF01522 (2/2) Polysaccharide deacetylase PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF00535 (2/2) Glycosyl transferase family 2 PF00501 (2/2) AMP-binding enzyme PF00202 (2/2) Aminotransferase class-III
precursor_groups_40558	609.27 +- 165.86	3	0	3	0	0.01 +- 0.00	3	11 TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase PF14518 (3/3) Iron-containing redox enzyme PF13378 (3/3) Enolase C-terminal domain-like PF07690 (3/3) Major Facilitator Superfamily PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (3/3) Peptidase family M20/M25/M40 PF01063 (3/3) Amino-transferase class IV PF00682 (3/3) HMGL-like TIGR00035 (2/3) aspartate racemase PF01177 (2/3) Asp/Glu/Hydantoin racemase
precursor_groups_24923	595.57 +- 149.62	4	0	4	0	0.01 +- 0.00	4	17 TIGR01509 (4/4) HAD hydrolase, family IA, variant 3 PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1 PF16864 (4/4) Dimerisation domain PF14015 (4/4) Protein of unknown function (DUF4231) PF13692 (4/4) Glycosyl transferases group 1 PF13676 (4/4) TIR domain PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13419 (4/4) Haloacid dehalogenase-like hydrolase PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase PF12464 (4/4) Maltose acetyltransferase PF11941 (4/4) Domain of unknown function (DUF3459) PF07728 (4/4) AAA domain (dynein-related subfamily) PF05729 (4/4) NACHT domain PF01636 (4/4) Phosphotransferase enzyme family PF00891 (4/4) O-methyltransferase domain PF00202 (4/4) Aminotransferase class-III PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
precursor_groups_20597	400.13 +- 221.16	3	0	1	0	0.05 +- 0.17	3	26 TIGR02100 (3/3) glycogen debranching enzyme GlgX TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme TIGR00377 (3/3) anti-anti-sigma factor PF18085 (3/3) Maltokinase N-terminal cap domain PF17124 (3/3) ThiJ/PfpI family-like PF13614 (3/3) AAA domain PF13581 (3/3) Histidine kinase-like ATPase domain PF13546 (3/3) DDE superfamily endonuclease PF13466 (3/3) STAS domain PF13460 (3/3) NAD(P)H-binding PF13380 (3/3) CoA binding domain PF11896 (3/3) Domain of unknown function (DUF3416) PF07690 (3/3) Major Facilitator Superfamily PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) PF07110 (3/3) EthD domain PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain) PF02806 (3/3) Alpha amylase, C-terminal all-beta domain PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01965 (3/3) DJ-1/PfpI family PF01740 (3/3) STAS domain PF00483 (3/3) Nucleotidyl transferase PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain PF00132 (3/3) Bacterial transferase hexapeptide (six repeats) PF00128 (3/3) Alpha amylase, catalytic domain
precursor_groups_22333	154.80 +- 0.00	2	0	0	0	0.02 +- 0.01	2	5 TIGR01549 (2/2) HAD hydrolase, family IA, variant 1 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF09130 (2/2) Domain of unknown function (DUF1932) PF02384 (2/2) N-6 DNA Methylase PF01341 (2/2) Glycosyl hydrolases family 6
precursor_groups_12158	2061.33 +- 765.80	7	0	0	0	0.01 +- 0.01	7	12 PF17874 (7/7) MalT-like TPR region PF13560 (7/7) Helix-turn-helix domain PF13393 (7/7) Histidyl-tRNA synthetase PF05193 (7/7) Peptidase M16 inactive domain PF03721 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02585 (7/7) GlcNAc-PI de-N-acetylase PF01370 (7/7) NAD dependent epimerase/dehydratase family PF01061 (7/7) ABC-2 type transporter PF00984 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00675 (7/7) Insulinase (Peptidase family M16) PF00005 (7/7) ABC transporter
precursor_groups_61591	306.43 +- 83.57	2	0	2	0	0.01 +- 0.00	2	7 PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF07690 (2/2) Major Facilitator Superfamily PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00155 (2/2) Aminotransferase class I and II
precursor_groups_6342	216.00 +- 44.00	2	0	0	0	0.03 +- 0.04	2	4 TIGR01910 (2/2) peptidase, ArgE/DapE family PF01546 (2/2) Peptidase family M20/M25/M40 PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_1450	759.98 +- 690.09	3	0	3	3	0.06 +- 0.20	3	6 PF06114 (3/3) IrrE N-terminal-like domain PF05147 (3/3) Lanthionine synthetase C-like protein PF02687 (3/3) FtsX-like permease family PF00082 (3/3) Subtilase family PF00069 (3/3) Protein kinase domain PF00005 (3/3) ABC transporter
precursor_groups_14823	174.93 +- 114.89	6	0	0	0	0.03 +- 0.05	6	8 PF13577 (6/6) SnoaL-like domain PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase PF12697 (6/6) Alpha/beta hydrolase family PF07690 (6/6) Major Facilitator Superfamily PF04444 (6/6) Catechol dioxygenase N terminus PF01261 (6/6) Xylose isomerase-like TIM barrel PF00775 (6/6) Dioxygenase PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_groups_1355	178.94 +- 79.06	2	0	0	0	0.04 +- 0.07	2	5 PF00067 (2/2) Cytochrome P450 PF14534 (1/2) Domain of unknown function (DUF4440) PF08002 (1/2) Protein of unknown function (DUF1697) PF05922 (1/2) Peptidase inhibitor I9 PF00082 (1/2) Subtilase family
precursor_groups_45774	344.00 +- 86.00	2	0	0	0	0.01 +- 0.01	2	7 TIGR03696 (2/2) RHS repeat-associated core domain TIGR01643 (2/2) YD repeat (two copies) PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF13424 (2/2) Tetratricopeptide repeat PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic PF05593 (2/2) RHS Repeat PF00156 (2/2) Phosphoribosyl transferase domain
precursor_groups_73507	1554.00 +- 6.00	2	0	2	0	0.01 +- 0.00	2	7 PF08007 (2/2) Cupin superfamily protein PF03412 (2/2) Peptidase C39 family PF00668 (2/2) Condensation domain PF00664 (2/2) ABC transporter transmembrane region PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00005 (2/2) ABC transporter
precursor_groups_9108	117.34 +- 48.52	2	0	2	0	0.03 +- 0.04	2	4 PF07883 (2/2) Cupin domain PF01872 (2/2) RibD C-terminal domain PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_groups_64153	258.09 +- 86.03	2	0	0	2	0.03 +- 0.05	2	13 PF17676 (2/2) LD-carboxypeptidase C-terminal domain PF13581 (2/2) Histidine kinase-like ATPase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13280 (2/2) WYL domain PF08279 (2/2) HTH domain PF04055 (2/2) Radical SAM superfamily PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family PF02310 (2/2) B12 binding domain PF02016 (2/2) LD-carboxypeptidase N-terminal domain PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein PF00293 (2/2) NUDIX domain PF00152 (2/2) tRNA synthetases class II (D, K and N) PF00005 (2/2) ABC transporter
precursor_groups_84823	3194.97 +- 210.63	2	0	0	0	0.02 +- 0.01	2	13 TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (2/2) ATP-grasp domain PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (2/2) Prephenate dehydrogenase PF01613 (2/2) Flavin reductase like domain PF01070 (2/2) FMN-dependent dehydrogenase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (2/2) Luciferase-like monooxygenase PF00155 (2/2) Aminotransferase class I and II PF00106 (2/2) short chain dehydrogenase
precursor_groups_78012	710.45 +- 47.26	2	0	2	2	0.03 +- 0.03	2	20 TIGR04364 (2/2) methyltransferase, FxLD system TIGR04363 (2/2) FxLD family lantipeptide TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF05331 (2/2) Protein of unknown function (DUF742) PF05147 (2/2) Lanthionine synthetase C-like protein PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03259 (2/2) Roadblock/LC7 domain PF03029 (2/2) Conserved hypothetical ATP binding protein PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF01590 (2/2) GAF domain PF01427 (2/2) D-ala-D-ala dipeptidase PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00293 (2/2) NUDIX domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
precursor_groups_6043	131.54 +- 3.07	2	0	0	0	0.09 +- 0.06	2	10 TIGR01382 (2/2) intracellular protease, PfpI family PF13823 (2/2) Alcohol dehydrogenase GroES-associated PF09123 (2/2) Domain of unknown function (DUF1931) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07690 (2/2) Major Facilitator Superfamily PF01965 (2/2) DJ-1/PfpI family PF00248 (2/2) Aldo/keto reductase family PF00107 (2/2) Zinc-binding dehydrogenase PF13515 (1/2) Fusaric acid resistance protein-like PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_groups_70686	650.00 +- 0.00	2	0	0	0	0.02 +- 0.00	2	6 TIGR01484 (2/2) HAD hydrolase, family IIB PF08282 (2/2) haloacid dehalogenase-like hydrolase PF07690 (2/2) Major Facilitator Superfamily PF01259 (2/2) SAICAR synthetase PF00326 (2/2) Prolyl oligopeptidase family PF00106 (2/2) short chain dehydrogenase
precursor_groups_71289	155.40 +- 85.40	2	0	0	0	0.04 +- 0.04	2	6 TIGR03921 (2/2) type VII secretion-associated serine protease mycosin PF07729 (2/2) FCD domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00293 (2/2) NUDIX domain PF00221 (2/2) Aromatic amino acid lyase PF00082 (2/2) Subtilase family
precursor_groups_1957	91.17 +- 58.33	18	0	0	0	0.03 +- 0.02	18	3 PF12833 (18/18) Helix-turn-helix domain PF02311 (18/18) AraC-like ligand binding domain PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)
precursor_groups_165	32.06 +- 9.93	8	0	0	0	0.07 +- 0.05	8	4 PF17074 (8/8) Darcynin, domain of unknown function PF08021 (8/8) Siderophore-interacting FAD-binding domain PF04954 (8/8) Siderophore-interacting protein PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_5606	65.80 +- 23.86	2	0	1	0	0.05 +- 0.06	2	8 PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00672 (2/2) HAMP domain PF00553 (2/2) Cellulose binding domain PF00512 (2/2) His Kinase A (phospho-acceptor) domain TIGR01180 (1/2) putative alpha-1,2-mannosidase PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain PF07971 (1/2) Glycosyl hydrolase family 92
precursor_groups_79714	2072.00 +- 8.00	2	0	0	0	0.01 +- 0.00	2	7 PF08386 (2/2) TAP-like protein PF07702 (2/2) UTRA domain PF01380 (2/2) SIS domain PF00561 (2/2) alpha/beta hydrolase fold PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_17666	49.71 +- 15.29	2	0	2	2	0.07 +- 0.08	2	6 PF14518 (2/2) Iron-containing redox enzyme PF13191 (2/2) AAA ATPase domain PF13185 (2/2) GAF domain PF04055 (2/2) Radical SAM superfamily PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain PF00082 (2/2) Subtilase family
precursor_groups_1821	358.75 +- 32.16	2	0	0	0	0.01 +- 0.01	2	18 TIGR01558 (2/2) putative phage terminase, small subunit, P27 family TIGR01554 (2/2) phage major capsid protein, HK97 family TIGR01543 (2/2) phage prohead protease, HK97 family TIGR01537 (2/2) phage portal protein, HK97 family PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein PF10145 (2/2) Phage-related minor tail protein PF05119 (2/2) Phage terminase, small subunit PF05065 (2/2) Phage capsid family PF04860 (2/2) Phage portal protein PF04851 (2/2) Type III restriction enzyme, res subunit PF04586 (2/2) Caudovirus prohead serine protease PF04542 (2/2) Sigma-70 region 2 PF03354 (2/2) Phage Terminase PF01844 (2/2) HNH endonuclease PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase PF01391 (2/2) Collagen triple helix repeat (20 copies) PF01381 (2/2) Helix-turn-helix PF00271 (2/2) Helicase conserved C-terminal domain
precursor_groups_68266	388.00 +- 128.00	2	0	0	0	0.01 +- 0.00	2	6 PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07729 (2/2) FCD domain PF02627 (2/2) Carboxymuconolactone decarboxylase family PF00753 (2/2) Metallo-beta-lactamase superfamily PF00561 (2/2) alpha/beta hydrolase fold PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_463	130.00 +- 70.00	2	0	0	0	0.04 +- 0.03	2	6 PF12833 (2/2) Helix-turn-helix domain PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term PF02416 (2/2) mttA/Hcf106 family PF00743 (2/2) Flavin-binding monooxygenase-like PF00171 (2/2) Aldehyde dehydrogenase family PF00106 (2/2) short chain dehydrogenase
precursor_groups_462	509.83 +- 454.74	34	0	18	1	0.05 +- 0.15	34	15 TIGR01850 (34/34) N-acetyl-gamma-glutamyl-phosphate reductase PF08443 (34/34) RimK-like ATP-grasp domain PF02779 (34/34) Transketolase, pyrimidine binding domain PF01118 (34/34) Semialdehyde dehydrogenase, NAD binding domain PF00456 (34/34) Transketolase, thiamine diphosphate binding domain TIGR00768 (30/34) alpha-L-glutamate ligase, RimK family TIGR01902 (23/34) N-acetyl-ornithine/N-acetyl-lysine deacetylase PF01546 (23/34) Peptidase family M20/M25/M40 PF01041 (23/34) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (23/34) Amino acid kinase family PF07690 (18/34) Major Facilitator Superfamily PF18603 (17/34) L-amino acid ligase C-terminal domain 2 PF18130 (17/34) ATP-grasp N-terminal domain PF13535 (17/34) ATP-grasp domain PF02780 (17/34) Transketolase, C-terminal domain
precursor_groups_9061	189.23 +- 42.98	2	0	0	0	0.02 +- 0.01	2	5 PF13191 (2/2) AAA ATPase domain PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport PF05199 (2/2) GMC oxidoreductase PF00732 (2/2) GMC oxidoreductase PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_500	726.73 +- 607.66	2	0	1	1	0.08 +- 0.19	2	21 TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/2) SagB-type dehydrogenase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01891 (1/2) amidohydrolase PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF07730 (1/2) Histidine kinase PF04738 (1/2) Lantibiotic dehydratase, N terminus PF03412 (1/2) Peptidase C39 family PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01546 (1/2) Peptidase family M20/M25/M40 PF01145 (1/2) SPFH domain / Band 7 family PF01061 (1/2) ABC-2 type transporter PF00881 (1/2) Nitroreductase family PF00877 (1/2) NlpC/P60 family PF00664 (1/2) ABC transporter transmembrane region PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00072 (1/2) Response regulator receiver domain PF00067 (1/2) Cytochrome P450 PF00005 (1/2) ABC transporter
precursor_groups_265	135.53 +- 39.47	2	0	0	0	0.06 +- 0.09	2	9 TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family PF17964 (2/2) Bacterial Ig domain PF13411 (2/2) MerR HTH family regulatory protein PF08281 (2/2) Sigma-70, region 4 PF07739 (2/2) TipAS antibiotic-recognition domain PF04542 (2/2) Sigma-70 region 2 PF03734 (2/2) L,D-transpeptidase catalytic domain PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_44077	763.96 +- 609.16	2	0	2	1	0.05 +- 0.14	2	24 TIGR03696 (2/2) RHS repeat-associated core domain TIGR03494 (2/2) salicylate synthase TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family TIGR01733 (2/2) amino acid adenylation domain TIGR01643 (2/2) YD repeat (two copies) TIGR01443 (2/2) intein C-terminal splicing region PF13193 (2/2) AMP-binding enzyme C-terminal domain PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep) PF07591 (2/2) Pretoxin HINT domain PF05593 (2/2) RHS Repeat PF03704 (2/2) Bacterial transcriptional activator domain PF02361 (2/2) Cobalt transport protein PF00975 (2/2) Thioesterase domain PF00931 (2/2) NB-ARC domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00425 (2/2) chorismate binding enzyme PF00005 (2/2) ABC transporter TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing) PF13537 (1/2) Glutamine amidotransferase domain PF00733 (1/2) Asparagine synthase PF00664 (1/2) ABC transporter transmembrane region
precursor_groups_41937	915.56 +- 502.62	2	0	0	0	0.01 +- 0.01	2	8 PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07722 (2/2) Peptidase C26 PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF00202 (2/2) Aminotransferase class-III PF00171 (2/2) Aldehyde dehydrogenase family PF00120 (2/2) Glutamine synthetase, catalytic domain PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_22977	3011.04 +- 331.81	2	0	2	2	0.01 +- 0.01	2	8 PF13649 (2/2) Methyltransferase domain PF12730 (2/2) ABC-2 family transporter protein PF05147 (2/2) Lanthionine synthetase C-like protein PF00465 (2/2) Iron-containing alcohol dehydrogenase PF00296 (2/2) Luciferase-like monooxygenase PF00202 (2/2) Aminotransferase class-III PF00069 (2/2) Protein kinase domain PF00005 (2/2) ABC transporter
precursor_groups_4638	1058.04 +- 888.53	15	0	12	0	0.05 +- 0.18	15	18 TIGR01307 (15/15) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF13535 (15/15) ATP-grasp domain PF13480 (15/15) Acetyltransferase (GNAT) domain PF13115 (15/15) YtkA-like PF04389 (15/15) Peptidase family M28 PF02627 (15/15) Carboxymuconolactone decarboxylase family PF01676 (15/15) Metalloenzyme superfamily PF00664 (15/15) ABC transporter transmembrane region PF00403 (15/15) Heavy-metal-associated domain PF00275 (15/15) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00155 (15/15) Aminotransferase class I and II PF00117 (15/15) Glutamine amidotransferase class-I PF00005 (15/15) ABC transporter TIGR01525 (14/15) heavy metal translocating P-type ATPase TIGR01356 (14/15) 3-phosphoshikimate 1-carboxyvinyltransferase PF13549 (14/15) ATP-grasp domain PF00702 (14/15) haloacid dehalogenase-like hydrolase PF00122 (14/15) E1-E2 ATPase
precursor_groups_15205	169.73 +- 174.91	6	0	0	0	0.05 +- 0.09	6	10 TIGR00229 (6/6) PAS domain S-box protein PF08448 (6/6) PAS fold PF08220 (6/6) DeoR-like helix-turn-helix domain PF07228 (6/6) Stage II sporulation protein E (SpoIIE) PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain PF01590 (6/6) GAF domain PF00455 (6/6) DeoR C terminal sensor domain PF00440 (6/6) Bacterial regulatory proteins, tetR family PF00069 (6/6) Protein kinase domain PF01494 (3/6) FAD binding domain
precursor_groups_62121	151.58 +- 28.42	2	0	0	0	0.02 +- 0.02	2	3 PF13302 (2/2) Acetyltransferase (GNAT) domain PF07690 (2/2) Major Facilitator Superfamily PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_groups_62573	376.25 +- 0.00	2	0	0	2	0.03 +- 0.03	2	20 TIGR01656 (2/2) histidinol-phosphate phosphatase domain TIGR01444 (2/2) methyltransferase, FkbM family PF16363 (2/2) GDP-mannose 4,6 dehydratase PF13242 (2/2) HAD-hyrolase-like PF12804 (2/2) MobA-like NTP transferase domain PF12146 (2/2) Serine aminopeptidase, S33 PF05050 (2/2) Methyltransferase FkbM domain PF04055 (2/2) Radical SAM superfamily PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PF02709 (2/2) N-terminal domain of galactosyltransferase PF01370 (2/2) NAD dependent epimerase/dehydratase family PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00891 (2/2) O-methyltransferase domain PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00535 (2/2) Glycosyl transferase family 2 PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain PF00293 (2/2) NUDIX domain PF00037 (2/2) 4Fe-4S binding domain
precursor_groups_53738	2291.55 +- 1062.45	2	0	0	0	0.01 +- 0.01	2	14 PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13535 (2/2) ATP-grasp domain PF13378 (2/2) Enolase C-terminal domain-like PF12146 (2/2) Serine aminopeptidase, S33 PF08241 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF03321 (2/2) GH3 auxin-responsive promoter PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF00694 (2/2) Aconitase C-terminal domain PF00330 (2/2) Aconitase family (aconitate hydratase)
precursor_groups_28574	274.58 +- 189.71	2	0	2	0	0.03 +- 0.05	2	10 PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF08659 (2/2) KR domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF00698 (2/2) Acyl transferase domain PF00561 (2/2) alpha/beta hydrolase fold PF00550 (2/2) Phosphopantetheine attachment site PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_2083	224.43 +- 53.86	3	0	0	0	0.03 +- 0.04	3	6 PF07690 (3/3) Major Facilitator Superfamily PF04542 (3/3) Sigma-70 region 2 PF01435 (3/3) Peptidase family M48 PF00775 (3/3) Dioxygenase PF00583 (3/3) Acetyltransferase (GNAT) family PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_20660	144.72 +- 11.28	2	0	2	2	0.04 +- 0.04	2	3 PF13471 (2/2) Transglutaminase-like superfamily PF13302 (2/2) Acetyltransferase (GNAT) domain PF00733 (2/2) Asparagine synthase
precursor_groups_1011	122.11 +- 96.49	3	0	0	0	0.03 +- 0.04	3	5 TIGR01840 (3/3) esterase, PHB depolymerase family TIGR00666 (3/3) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase PF14016 (3/3) Protein of unknown function (DUF4232) PF10503 (3/3) Esterase PHB depolymerase PF02113 (3/3) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_groups_58650	454.25 +- 29.50	2	0	2	2	0.02 +- 0.02	2	13 TIGR00928 (2/2) adenylosuccinate lyase PF13673 (2/2) Acetyltransferase (GNAT) domain PF13454 (2/2) FAD-NAD(P)-binding PF10397 (2/2) Adenylosuccinate lyase C-terminus PF07969 (2/2) Amidohydrolase family PF07690 (2/2) Major Facilitator Superfamily PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF03704 (2/2) Bacterial transcriptional activator domain PF01425 (2/2) Amidase PF00931 (2/2) NB-ARC domain PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00206 (2/2) Lyase PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_groups_5459	235.19 +- 41.40	6	0	1	0	0.02 +- 0.01	6	7 TIGR03920 (6/6) type VII secretion integral membrane protein EccD TIGR03919 (6/6) type VII secretion protein EccB PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD PF07179 (6/6) SseB protein N-terminal domain PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B PF04488 (6/6) Glycosyltransferase sugar-binding region containing DXD motif PF02575 (6/6) YbaB/EbfC DNA-binding family
precursor_groups_32866	197.39 +- 31.14	3	0	0	0	0.07 +- 0.11	3	15 TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (3/3) Domain of unknown function (DUF4380) PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF13407 (3/3) Periplasmic binding protein domain PF13378 (3/3) Enolase C-terminal domain-like PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF07729 (3/3) FCD domain PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (3/3) Branched-chain amino acid transport system / permease component PF01081 (3/3) KDPG and KHG aldolase PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00294 (3/3) pfkB family carbohydrate kinase PF00107 (3/3) Zinc-binding dehydrogenase PF00005 (3/3) ABC transporter
precursor_groups_10155	174.09 +- 18.88	3	0	0	0	0.07 +- 0.09	3	14 PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5 PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PF16355 (3/3) Domain of unknown function (DUF4982) PF14310 (3/3) Fibronectin type III-like domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain PF07859 (3/3) alpha/beta hydrolase fold PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_28226	98.93 +- 27.86	3	0	3	0	0.05 +- 0.05	3	6 PF18085 (3/3) Maltokinase N-terminal cap domain PF05547 (3/3) Immune inhibitor A peptidase M6 PF01433 (3/3) Peptidase family M1 domain PF08241 (2/3) Methyltransferase domain PF01183 (2/3) Glycosyl hydrolases family 25 PF00892 (2/3) EamA-like transporter family
precursor_groups_85472	390.00 +- 0.00	2	0	1	0	0.01 +- 0.00	2	4 PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01613 (2/2) Flavin reductase like domain PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00296 (2/2) Luciferase-like monooxygenase
precursor_groups_918	213.47 +- 171.99	14	0	12	14	0.02 +- 0.02	14	4 PF04055 (14/14) Radical SAM superfamily PF07690 (13/14) Major Facilitator Superfamily PF02897 (12/14) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (12/14) Prolyl oligopeptidase family
precursor_groups_28782	253.73 +- 93.57	2	0	0	0	0.05 +- 0.06	2	11 PF12802 (2/2) MarR family PF09339 (2/2) IclR helix-turn-helix domain PF07883 (2/2) Cupin domain PF07690 (2/2) Major Facilitator Superfamily PF01614 (2/2) Bacterial transcriptional regulator PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family PF01494 (2/2) FAD binding domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF04909 (1/2) Amidohydrolase PF04199 (1/2) Putative cyclase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_15497	1363.59 +- 571.41	2	0	0	0	0.01 +- 0.01	2	17 TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF13183 (2/2) 4Fe-4S dicluster domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07729 (2/2) FCD domain PF03737 (2/2) Aldolase/RraA PF02913 (2/2) FAD linked oxidases, C-terminal domain PF02754 (2/2) Cysteine-rich domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01565 (2/2) FAD binding domain PF01229 (2/2) Glycosyl hydrolases family 39 PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter
precursor_groups_20405	235.76 +- 54.49	2	0	0	0	0.08 +- 0.12	2	11 TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain PF14224 (2/2) Domain of unknown function (DUF4331) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07690 (2/2) Major Facilitator Superfamily PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PF00925 (2/2) GTP cyclohydrolase II PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00107 (2/2) Zinc-binding dehydrogenase PF00082 (2/2) Subtilase family
precursor_groups_37629	453.70 +- 99.16	2	0	0	0	0.03 +- 0.02	2	7 TIGR03296 (2/2) M6 family metalloprotease domain TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF00561 (2/2) alpha/beta hydrolase fold PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00005 (2/2) ABC transporter
precursor_groups_1673	545.07 +- 292.47	24	0	24	24	0.04 +- 0.09	24	6 PF05147 (24/24) Lanthionine synthetase C-like protein PF00664 (24/24) ABC transporter transmembrane region PF00326 (24/24) Prolyl oligopeptidase family PF00069 (24/24) Protein kinase domain PF00005 (24/24) ABC transporter PF04672 (23/24) S-adenosyl methyltransferase
precursor_groups_20705	261.23 +- 64.11	5	0	0	0	0.01 +- 0.01	5	6 PF13459 (5/5) 4Fe-4S single cluster domain PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF08386 (5/5) TAP-like protein PF03640 (5/5) Secreted repeat of unknown function PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00561 (5/5) alpha/beta hydrolase fold
precursor_groups_72197	895.44 +- 308.77	2	0	2	0	0.02 +- 0.03	2	15 TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF06368 (2/2) Methylaspartate mutase E chain (MutE) PF06339 (2/2) Ectoine synthase PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02310 (2/2) B12 binding domain PF01841 (2/2) Transglutaminase-like superfamily PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_45090	194.50 +- 52.12	2	0	0	0	0.07 +- 0.08	2	15 TIGR00976 (2/2) hydrolase CocE/NonD family protein TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family PF13977 (2/2) BetI-type transcriptional repressor, C-terminal PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07690 (2/2) Major Facilitator Superfamily PF04075 (2/2) F420H(2)-dependent quinone reductase PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00005 (2/2) ABC transporter TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
precursor_groups_8543	47.10 +- 5.79	3	0	0	0	0.06 +- 0.05	3	5 TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083 PF13302 (3/3) Acetyltransferase (GNAT) domain PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02036 (3/3) SCP-2 sterol transfer family
precursor_groups_10436	3120.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	13 TIGR04245 (2/2) N-acyltransferase NodA TIGR04243 (2/2) chitooligosaccharide deacetylase NodB TIGR04242 (2/2) chitooligosaccharide synthase NodC TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02474 (2/2) Nodulation protein A (NodA) PF01522 (2/2) Polysaccharide deacetylase PF01061 (2/2) ABC-2 type transporter PF00535 (2/2) Glycosyl transferase family 2 PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (2/2) ABC transporter
precursor_groups_42674	291.05 +- 29.25	2	0	0	0	0.08 +- 0.18	2	21 TIGR01928 (2/2) o-succinylbenzoate synthase TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF17676 (2/2) LD-carboxypeptidase C-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF12831 (2/2) FAD dependent oxidoreductase PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07883 (2/2) Cupin domain PF07690 (2/2) Major Facilitator Superfamily PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02515 (2/2) CoA-transferase family III PF02016 (2/2) LD-carboxypeptidase N-terminal domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01381 (2/2) Helix-turn-helix PF01380 (2/2) SIS domain PF00701 (2/2) Dihydrodipicolinate synthetase family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter
precursor_groups_84552	122.27 +- 27.73	2	0	2	0	0.02 +- 0.01	2	6 PF04073 (2/2) Aminoacyl-tRNA editing domain PF01116 (2/2) Fructose-bisphosphate aldolase class-II PF00892 (2/2) EamA-like transporter family PF00464 (2/2) Serine hydroxymethyltransferase PF04151 (1/2) Bacterial pre-peptidase C-terminal domain PF00082 (1/2) Subtilase family
precursor_groups_21947	420.25 +- 97.76	4	0	4	0	0.01 +- 0.00	4	6 PF03412 (4/4) Peptidase C39 family PF00668 (4/4) Condensation domain PF00664 (4/4) ABC transporter transmembrane region PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00005 (4/4) ABC transporter
precursor_groups_14303	191.56 +- 72.66	4	0	0	0	0.07 +- 0.11	4	11 TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF14224 (4/4) Domain of unknown function (DUF4331) PF08240 (4/4) Alcohol dehydrogenase GroES-like domain PF07690 (4/4) Major Facilitator Superfamily PF00925 (4/4) GTP cyclohydrolase II PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00107 (4/4) Zinc-binding dehydrogenase PF00082 (3/4) Subtilase family PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_1009	1097.05 +- 1032.42	46	7	39	45	0.03 +- 0.09	39	7 PF13575 (45/46) Domain of unknown function (DUF4135) PF05147 (45/46) Lanthionine synthetase C-like protein TIGR03897 (44/46) type 2 lantibiotic biosynthesis protein LanM PF03412 (44/46) Peptidase C39 family PF00664 (44/46) ABC transporter transmembrane region PF00005 (44/46) ABC transporter PF14867 (43/46) Lantibiotic alpha
precursor_groups_48611	52.32 +- 21.97	2	0	2	0	0.05 +- 0.02	2	2 PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_16355	383.81 +- 168.05	5	0	0	5	0.01 +- 0.03	5	7 TIGR00702 (5/5) YcaO-type kinase domain PF18029 (5/5) Glyoxalase-like domain PF13489 (5/5) Methyltransferase domain PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase PF07812 (5/5) TfuA-like protein PF07690 (5/5) Major Facilitator Superfamily PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_groups_40542	328.15 +- 104.38	2	0	2	0	0.07 +- 0.16	2	15 TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF12146 (2/2) Serine aminopeptidase, S33 PF07977 (2/2) FabA-like domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain PF01323 (2/2) DSBA-like thioredoxin domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF12697 (1/2) Alpha/beta hydrolase family PF02785 (1/2) Biotin carboxylase C-terminal domain PF00364 (1/2) Biotin-requiring enzyme PF00289 (1/2) Biotin carboxylase, N-terminal domain
precursor_groups_76415	96.37 +- 5.37	2	0	0	0	0.03 +- 0.04	2	4 PF13480 (2/2) Acetyltransferase (GNAT) domain PF02156 (2/2) Glycosyl hydrolase family 26 PF01522 (2/2) Polysaccharide deacetylase PF00535 (2/2) Glycosyl transferase family 2
precursor_groups_42	40.24 +- 11.75	3	0	0	0	0.08 +- 0.17	3	3 TIGR03296 (3/3) M6 family metalloprotease domain PF09339 (3/3) IclR helix-turn-helix domain PF03777 (3/3) ChpA-C
precursor_groups_42811	650.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	1 PF13367 (2/2) PrsW family intramembrane metalloprotease
precursor_groups_49	249.44 +- 156.55	16	8	7	10	0.05 +- 0.06	8	4 PF00005 (16/16) ABC transporter PF00664 (14/16) ABC transporter transmembrane region PF00069 (13/16) Protein kinase domain PF05147 (9/16) Lanthionine synthetase C-like protein
precursor_groups_80550	1607.67 +- 212.33	2	0	2	0	0.01 +- 0.00	2	31 TIGR01733 (2/2) amino acid adenylation domain TIGR01686 (2/2) FkbH domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF13649 (2/2) Methyltransferase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12844 (2/2) Helix-turn-helix domain PF08892 (2/2) YqcI/YcgG family PF07690 (2/2) Major Facilitator Superfamily PF03486 (2/2) HI0933-like protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02780 (2/2) Transketolase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF01636 (2/2) Phosphotransferase enzyme family PF01409 (2/2) tRNA synthetases class II core domain (F) PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF17874 (1/2) MalT-like TPR region
precursor_groups_51837	1068.75 +- 101.25	2	0	0	0	0.01 +- 0.00	2	5 PF13416 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF00962 (2/2) Adenosine/AMP deaminase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_groups_50833	80.77 +- 3.37	2	0	0	0	0.06 +- 0.08	2	8 PF07690 (2/2) Major Facilitator Superfamily PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02515 (2/2) CoA-transferase family III PF00932 (2/2) Lamin Tail Domain PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_groups_15659	52.65 +- 10.40	3	0	0	0	0.06 +- 0.07	3	5 PF13460 (3/3) NAD(P)H-binding PF08592 (3/3) Domain of unknown function (DUF1772) PF01814 (3/3) Hemerythrin HHE cation binding domain PF12852 (2/3) Cupin PF12833 (2/3) Helix-turn-helix domain
precursor_groups_321	32.76 +- 4.10	2	0	0	0	0.06 +- 0.03	2	2 PF08007 (2/2) Cupin superfamily protein PF00248 (2/2) Aldo/keto reductase family
precursor_groups_6316	468.39 +- 239.31	3	0	0	0	0.03 +- 0.02	3	14 TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13460 (3/3) NAD(P)H-binding PF07690 (3/3) Major Facilitator Superfamily PF01814 (3/3) Hemerythrin HHE cation binding domain PF01494 (3/3) FAD binding domain PF00561 (3/3) alpha/beta hydrolase fold TIGR00928 (2/3) adenylosuccinate lyase PF13673 (2/3) Acetyltransferase (GNAT) domain PF12800 (2/3) 4Fe-4S binding domain PF01425 (2/3) Amidase PF00486 (2/3) Transcriptional regulatory protein, C terminal PF00206 (2/3) Lyase PF00120 (2/3) Glutamine synthetase, catalytic domain PF00072 (2/3) Response regulator receiver domain
precursor_groups_82367	322.38 +- 56.79	2	0	0	0	0.02 +- 0.02	2	6 PF09339 (2/2) IclR helix-turn-helix domain PF01614 (2/2) Bacterial transcriptional regulator PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00175 (2/2) Oxidoreductase NAD-binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00067 (2/2) Cytochrome P450
precursor_groups_5888	778.00 +- 2.83	3	0	0	3	0.01 +- 0.00	3	8 TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (3/3) SagB-type dehydrogenase domain PF16058 (3/3) Mucin-like PF07690 (3/3) Major Facilitator Superfamily PF03972 (3/3) MmgE/PrpD family PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (3/3) Nitroreductase family PF00675 (3/3) Insulinase (Peptidase family M16)
precursor_groups_733	5756.47 +- 1500.30	3	0	3	3	0.01 +- 0.01	3	11 TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD) PF04738 (3/3) Lantibiotic dehydratase, N terminus PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (3/3) Nitroreductase family PF00005 (3/3) ABC transporter TIGR01189 (2/3) heme ABC exporter, ATP-binding protein CcmA PF12698 (2/3) ABC-2 family transporter protein
precursor_groups_730	1147.46 +- 656.81	23	5	18	23	0.02 +- 0.04	18	8 TIGR03897 (23/23) type 2 lantibiotic biosynthesis protein LanM PF13575 (23/23) Domain of unknown function (DUF4135) PF05147 (23/23) Lanthionine synthetase C-like protein PF03412 (22/23) Peptidase C39 family PF00664 (22/23) ABC transporter transmembrane region PF00005 (22/23) ABC transporter TIGR03898 (20/23) type 2 lantibiotic, mersacidin/lichenicidin family PF12679 (14/23) ABC-2 family transporter protein
precursor_groups_83733	4608.81 +- 2021.19	2	0	2	0	0.02 +- 0.03	2	16 PF17914 (2/2) HopA1 effector protein family PF13649 (2/2) Methyltransferase domain PF11468 (2/2) Aromatic prenyltransferase Orf2 PF05193 (2/2) Peptidase M16 inactive domain PF02441 (2/2) Flavoprotein PF01527 (2/2) Transposase PF01061 (2/2) ABC-2 type transporter PF00675 (2/2) Insulinase (Peptidase family M16) PF00664 (2/2) ABC transporter transmembrane region PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter PF13847 (1/2) Methyltransferase domain PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF13489 (1/2) Methyltransferase domain PF00183 (1/2) Hsp90 protein PF00069 (1/2) Protein kinase domain
precursor_groups_2450	27.06 +- 5.19	2	0	0	0	0.09 +- 0.10	2	7 PF13516 (2/2) Leucine Rich repeat PF13203 (2/2) Putative metallopeptidase domain PF09967 (2/2) VWA-like domain (DUF2201) PF07728 (2/2) AAA domain (dynein-related subfamily) PF14435 (1/2) SUKH-4 immunity protein PF12796 (1/2) Ankyrin repeats (3 copies) PF01738 (1/2) Dienelactone hydrolase family
precursor_groups_46115	186.14 +- 8.86	2	0	0	0	0.03 +- 0.04	2	6 PF13564 (2/2) DoxX-like family PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF03358 (2/2) NADPH-dependent FMN reductase PF00440 (2/2) Bacterial regulatory proteins, tetR family PF18616 (1/2) CDI immunity proteins
precursor_groups_2515	339.13 +- 0.00	2	0	0	0	0.03 +- 0.01	2	8 TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1) PF04679 (2/2) ATP dependent DNA ligase C terminal region PF04675 (2/2) DNA ligase N terminus PF01547 (2/2) Bacterial extracellular solute-binding protein PF01380 (2/2) SIS domain PF01068 (2/2) ATP dependent DNA ligase domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_81827	516.00 +- 0.00	2	0	2	0	0.01 +- 0.00	2	4 PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent PF03781 (2/2) Sulfatase-modifying factor enzyme 1 PF02450 (2/2) Lecithin:cholesterol acyltransferase PF00400 (2/2) WD domain, G-beta repeat
precursor_groups_9139	7843.20 +- 6508.80	2	0	2	2	0.05 +- 0.15	2	21 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (2/2) SagB-type dehydrogenase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01891 (2/2) amidohydrolase PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF07730 (2/2) Histidine kinase PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03412 (2/2) Peptidase C39 family PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01546 (2/2) Peptidase family M20/M25/M40 PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00664 (2/2) ABC transporter transmembrane region PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00072 (2/2) Response regulator receiver domain PF00067 (2/2) Cytochrome P450 PF00005 (2/2) ABC transporter PF14310 (1/2) Fibronectin type III-like domain PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_groups_14447	122.10 +- 43.38	4	0	0	0	0.05 +- 0.04	4	12 TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01891 (4/4) amidohydrolase TIGR00843 (4/4) benzoate transporter PF13454 (4/4) FAD-NAD(P)-binding PF13424 (4/4) Tetratricopeptide repeat PF03594 (4/4) Benzoate membrane transport protein PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family PF01546 (4/4) Peptidase family M20/M25/M40 PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme PF00931 (4/4) NB-ARC domain PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_groups_429	687.94 +- 313.54	3	1	2	3	0.02 +- 0.02	2	11 TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term PF05147 (3/3) Lanthionine synthetase C-like protein PF04738 (3/3) Lantibiotic dehydratase, N terminus PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (3/3) Nitroreductase family PF00069 (3/3) Protein kinase domain TIGR03605 (2/3) SagB-type dehydrogenase domain PF00494 (2/3) Squalene/phytoene synthase
precursor_groups_32192	365.31 +- 284.69	2	0	0	0	0.03 +- 0.05	2	3 PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF00246 (2/2) Zinc carboxypeptidase
precursor_groups_427	3858.25 +- 1997.49	19	0	19	19	0.02 +- 0.06	19	7 TIGR03882 (19/19) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (19/19) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (19/19) Lantibiotic biosynthesis dehydratase C-term PF02624 (19/19) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (19/19) Nitroreductase family PF00005 (13/19) ABC transporter PF05402 (10/19) Coenzyme PQQ synthesis protein D (PqqD)
precursor_groups_12981	276.85 +- 62.50	3	0	0	0	0.02 +- 0.02	3	5 PF13924 (3/3) Lipocalin-like domain PF07690 (3/3) Major Facilitator Superfamily PF00857 (3/3) Isochorismatase family PF00171 (3/3) Aldehyde dehydrogenase family PF00082 (2/3) Subtilase family
precursor_groups_132	112.76 +- 103.65	3	0	0	0	0.05 +- 0.07	3	No common domains found
precursor_groups_67117	100.71 +- 10.71	2	0	0	0	0.06 +- 0.04	2	3 PF04672 (2/2) S-adenosyl methyltransferase PF01872 (2/2) RibD C-terminal domain PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_48975	292.50 +- 0.00	2	0	0	0	0.01 +- 0.00	2	3 PF01323 (2/2) DSBA-like thioredoxin domain PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00082 (2/2) Subtilase family
precursor_groups_42689	1292.60 +- 296.28	2	0	2	2	0.03 +- 0.02	2	9 TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM PF14867 (2/2) Lantibiotic alpha PF13575 (2/2) Domain of unknown function (DUF4135) PF05147 (2/2) Lanthionine synthetase C-like protein PF03412 (2/2) Peptidase C39 family PF00664 (2/2) ABC transporter transmembrane region PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter PF13556 (1/2) PucR C-terminal helix-turn-helix domain
precursor_groups_45864	1855.31 +- 282.62	3	0	3	0	0.04 +- 0.15	3	33 TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR01733 (3/3) amino acid adenylation domain TIGR01686 (3/3) FkbH domain TIGR00976 (3/3) hydrolase CocE/NonD family protein PF18563 (3/3) TubC N-terminal docking domain PF16197 (3/3) Ketoacyl-synthetase C-terminal extension PF14765 (3/3) Polyketide synthase dehydratase PF13602 (3/3) Zinc-binding dehydrogenase PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08659 (3/3) KR domain PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF03621 (3/3) MbtH-like protein PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02195 (3/3) ParB-like nuclease domain PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family) PF01266 (3/3) FAD dependent oxidoreductase PF00975 (3/3) Thioesterase domain PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (3/3) Acyl transferase domain PF00668 (3/3) Condensation domain PF00664 (3/3) ABC transporter transmembrane region PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain PF00296 (3/3) Luciferase-like monooxygenase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF00005 (3/3) ABC transporter
precursor_groups_5499	174.02 +- 47.17	5	0	0	0	0.07 +- 0.10	5	7 PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF12680 (5/5) SnoaL-like domain PF07045 (5/5) Domain of unknown function (DUF1330) PF01738 (5/5) Dienelactone hydrolase family PF00664 (5/5) ABC transporter transmembrane region PF00440 (5/5) Bacterial regulatory proteins, tetR family PF00005 (5/5) ABC transporter
precursor_groups_26684	444.94 +- 356.18	4	0	0	0	0.03 +- 0.04	4	6 PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF03992 (4/4) Antibiotic biosynthesis monooxygenase PF00664 (4/4) ABC transporter transmembrane region PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00248 (4/4) Aldo/keto reductase family PF00005 (4/4) ABC transporter
precursor_groups_54637	69.96 +- 24.43	2	0	0	2	0.05 +- 0.09	2	11 TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family TIGR04268 (2/2) FXSXX-COOH protein TIGR04267 (2/2) HEXXH motif domain PF13676 (2/2) TIR domain PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF12680 (2/2) SnoaL-like domain PF04055 (2/2) Radical SAM superfamily PF01361 (2/2) Tautomerase enzyme PF00931 (2/2) NB-ARC domain
precursor_groups_12804	206.28 +- 77.96	4	0	0	0	0.09 +- 0.09	4	17 TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain PF16499 (4/4) Alpha galactosidase A PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13378 (4/4) Enolase C-terminal domain-like PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region PF07729 (4/4) FCD domain PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (4/4) Melibiase PF01547 (4/4) Bacterial extracellular solute-binding protein PF01081 (4/4) KDPG and KHG aldolase PF00583 (4/4) Acetyltransferase (GNAT) family PF00528 (4/4) Binding-protein-dependent transport system inner membrane component PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00294 (4/4) pfkB family carbohydrate kinase
precursor_groups_56365	433.58 +- 275.92	2	0	0	0	0.04 +- 0.03	2	8 TIGR00126 (2/2) deoxyribose-phosphate aldolase PF13407 (2/2) Periplasmic binding protein domain PF07702 (2/2) UTRA domain PF05025 (2/2) RbsD / FucU transport protein family PF02653 (2/2) Branched-chain amino acid transport system / permease component PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00005 (2/2) ABC transporter
precursor_groups_556	112.93 +- 162.01	47	4	40	47	0.04 +- 0.07	43	3 PF00733 (47/47) Asparagine synthase PF13471 (46/47) Transglutaminase-like superfamily PF05402 (46/47) Coenzyme PQQ synthesis protein D (PqqD)
precursor_groups_6671	258.67 +- 0.94	3	0	0	0	0.01 +- 0.00	3	2 PF01757 (3/3) Acyltransferase family PF00248 (3/3) Aldo/keto reductase family
precursor_groups_13764	233.66 +- 123.26	4	0	0	0	0.02 +- 0.03	4	6 PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain PF07690 (4/4) Major Facilitator Superfamily PF05922 (4/4) Peptidase inhibitor I9 PF00535 (4/4) Glycosyl transferase family 2 PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00082 (4/4) Subtilase family
precursor_groups_12543	129.86 +- 93.00	2	0	0	0	0.05 +- 0.10	2	3 PF03483 (2/2) B3/4 domain PF01810 (2/2) LysE type translocator PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_5653	964.27 +- 325.73	2	0	0	0	0.01 +- 0.02	2	12 PF10502 (2/2) Signal peptidase, peptidase S26 PF03704 (2/2) Bacterial transcriptional activator domain PF00931 (2/2) NB-ARC domain PF00899 (2/2) ThiF family PF00717 (2/2) Peptidase S24-like PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter TIGR02227 (1/2) signal peptidase I PF17874 (1/2) MalT-like TPR region PF11271 (1/2) Porin PorA PF07291 (1/2) Methylamine utilisation protein MauE PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_groups_75740	1430.00 +- 130.00	2	0	2	2	0.01 +- 0.00	2	16 TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase PF18105 (2/2) PGM1 C-terminal domain PF16861 (2/2) Carbamoyltransferase C-terminus PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF06969 (2/2) HemN C-terminal domain PF05977 (2/2) Transmembrane secretion effector PF04055 (2/2) Radical SAM superfamily PF02543 (2/2) Carbamoyltransferase N-terminus PF00975 (2/2) Thioesterase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00425 (2/2) chorismate binding enzyme PF00117 (2/2) Glutamine amidotransferase class-I PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_groups_819	59.27 +- 22.81	4	0	4	0	0.04 +- 0.07	4	6 PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase PF08241 (4/4) Methyltransferase domain PF04205 (4/4) FMN-binding domain PF02424 (4/4) ApbE family PF01794 (4/4) Ferric reductase like transmembrane component PF00175 (4/4) Oxidoreductase NAD-binding domain
precursor_groups_50706	129.50 +- 0.50	2	0	1	0	0.02 +- 0.00	2	5 PF12708 (2/2) Pectate lyase superfamily protein PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase PF01120 (2/2) Alpha-L-fucosidase PF00754 (2/2) F5/8 type C domain PF00295 (2/2) Glycosyl hydrolases family 28
precursor_groups_62248	77.60 +- 25.60	2	0	0	0	0.03 +- 0.02	2	6 PF14525 (2/2) AraC-binding-like domain PF12833 (2/2) Helix-turn-helix domain PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF01551 (2/2) Peptidase family M23 PF01471 (2/2) Putative peptidoglycan binding domain PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
precursor_groups_19855	277.22 +- 74.60	2	0	0	0	0.08 +- 0.08	2	22 TIGR01733 (2/2) amino acid adenylation domain PF18029 (2/2) Glyoxalase-like domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08713 (2/2) DNA alkylation repair enzyme PF08659 (2/2) KR domain PF07690 (2/2) Major Facilitator Superfamily PF07478 (2/2) D-ala D-ala ligase C-terminus PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01820 (2/2) D-ala D-ala ligase N-terminus PF01494 (2/2) FAD binding domain PF00975 (2/2) Thioesterase domain PF00850 (2/2) Histone deacetylase domain PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00698 (2/2) Acyl transferase domain PF00551 (2/2) Formyl transferase PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00355 (2/2) Rieske [2Fe-2S] domain PF00155 (2/2) Aminotransferase class I and II PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_64908	516.00 +- 258.00	2	0	0	0	0.02 +- 0.03	2	3 PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase PF00248 (2/2) Aldo/keto reductase family
precursor_groups_10742	114.31 +- 18.14	2	0	0	0	0.08 +- 0.04	2	5 PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain PF13416 (2/2) Bacterial extracellular solute-binding protein PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00266 (2/2) Aminotransferase class-V
precursor_groups_2334	222.67 +- 78.34	11	0	0	0	0.03 +- 0.02	11	10 TIGR03930 (11/11) WXG100 family type VII secretion target TIGR03920 (11/11) type VII secretion integral membrane protein EccD TIGR03919 (11/11) type VII secretion protein EccB PF15644 (11/11) Papain fold toxin 1, glutamine deamidase PF08817 (11/11) WXG100 protein secretion system (Wss), protein YukD PF07179 (11/11) SseB protein N-terminal domain PF06013 (11/11) Proteins of 100 residues with WXG PF05108 (11/11) Type VII secretion system ESX-1, transport TM domain B PF02575 (11/11) YbaB/EbfC DNA-binding family PF00652 (11/11) Ricin-type beta-trefoil lectin domain
precursor_groups_1282	192.97 +- 127.67	14	0	14	14	0.05 +- 0.03	14	13 TIGR04451 (14/14) lantipeptide, SCO0268 family TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term PF05147 (14/14) Lanthionine synthetase C-like protein PF04738 (14/14) Lantibiotic dehydratase, N terminus PF12802 (9/14) MarR family PF12697 (9/14) Alpha/beta hydrolase family PF02065 (9/14) Melibiase PF01547 (9/14) Bacterial extracellular solute-binding protein PF00528 (9/14) Binding-protein-dependent transport system inner membrane component PF00480 (9/14) ROK family PF02894 (8/14) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (8/14) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_29741	336.40 +- 91.11	4	0	0	0	0.01 +- 0.01	4	4 PF13649 (4/4) Methyltransferase domain PF07730 (4/4) Histidine kinase PF00196 (4/4) Bacterial regulatory proteins, luxR family PF00072 (4/4) Response regulator receiver domain
precursor_groups_1446	48.54 +- 0.65	2	0	0	0	0.08 +- 0.17	2	3 TIGR03296 (2/2) M6 family metalloprotease domain PF09339 (2/2) IclR helix-turn-helix domain PF03777 (2/2) ChpA-C
precursor_groups_21578	108.35 +- 37.40	3	0	1	0	0.09 +- 0.06	3	5 PF13411 (3/3) MerR HTH family regulatory protein PF03476 (3/3) MOSC N-terminal beta barrel domain PF03473 (3/3) MOSC domain PF01551 (3/3) Peptidase family M23 PF00248 (3/3) Aldo/keto reductase family
precursor_groups_15041	226.53 +- 46.37	3	0	0	0	0.07 +- 0.11	3	11 TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16859 (3/3) Tetracyclin repressor-like, C-terminal domain PF14224 (3/3) Domain of unknown function (DUF4331) PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF07690 (3/3) Major Facilitator Superfamily PF00925 (3/3) GTP cyclohydrolase II PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00107 (3/3) Zinc-binding dehydrogenase PF00082 (3/3) Subtilase family PF02882 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PF00763 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_groups_50390	3194.97 +- 210.63	2	0	0	0	0.02 +- 0.01	2	13 TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (2/2) ATP-grasp domain PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (2/2) Prephenate dehydrogenase PF01613 (2/2) Flavin reductase like domain PF01070 (2/2) FMN-dependent dehydrogenase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (2/2) Luciferase-like monooxygenase PF00155 (2/2) Aminotransferase class I and II PF00106 (2/2) short chain dehydrogenase
precursor_groups_15049	2401.56 +- 1135.16	3	0	0	0	0.02 +- 0.01	3	13 TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (3/3) ATP-grasp domain PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (3/3) Prephenate dehydrogenase PF01613 (3/3) Flavin reductase like domain PF01070 (3/3) FMN-dependent dehydrogenase PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (3/3) Luciferase-like monooxygenase PF00155 (3/3) Aminotransferase class I and II PF00106 (3/3) short chain dehydrogenase PF18130 (2/3) ATP-grasp N-terminal domain
precursor_groups_52507	134.01 +- 78.72	2	0	2	2	0.06 +- 0.05	2	9 PF13471 (2/2) Transglutaminase-like superfamily PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (2/2) Asparagine synthase PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter TIGR03696 (1/2) RHS repeat-associated core domain TIGR01643 (1/2) YD repeat (two copies) PF07591 (1/2) Pretoxin HINT domain PF05593 (1/2) RHS Repeat
precursor_groups_9354	479.19 +- 156.31	9	0	9	9	0.02 +- 0.01	9	7 PF07690 (9/9) Major Facilitator Superfamily PF04055 (9/9) Radical SAM superfamily PF03466 (9/9) LysR substrate binding domain PF02310 (9/9) B12 binding domain PF00733 (9/9) Asparagine synthase PF00501 (9/9) AMP-binding enzyme PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_64010	117.00 +- 13.00	2	0	2	0	0.02 +- 0.01	2	4 PF08386 (2/2) TAP-like protein PF08031 (2/2) Berberine and berberine like PF01565 (2/2) FAD binding domain PF00561 (2/2) alpha/beta hydrolase fold
precursor_groups_36155	216.00 +- 44.00	2	0	0	0	0.01 +- 0.00	2	3 PF13229 (2/2) Right handed beta helix region PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02018 (2/2) Carbohydrate binding domain
precursor_groups_72354	69.81 +- 25.74	2	0	0	0	0.07 +- 0.06	2	5 PF07690 (2/2) Major Facilitator Superfamily PF05893 (2/2) Acyl-CoA reductase (LuxC) PF04443 (2/2) Acyl-protein synthetase, LuxE PF00583 (2/2) Acetyltransferase (GNAT) family PF00501 (2/2) AMP-binding enzyme
precursor_groups_2029	291.55 +- 224.45	2	0	0	0	0.03 +- 0.06	2	1 PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_10969	877.59 +- 552.41	2	0	0	2	0.02 +- 0.06	2	10 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF17914 (2/2) HopA1 effector protein family PF13469 (2/2) Sulfotransferase family PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01636 (2/2) Phosphotransferase enzyme family PF00664 (2/2) ABC transporter transmembrane region PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_groups_39	50.96 +- 24.18	3	0	0	0	0.05 +- 0.03	3	3 PF13520 (3/3) Amino acid permease PF00202 (3/3) Aminotransferase class-III PF00171 (3/3) Aldehyde dehydrogenase family
precursor_groups_585	93.44 +- 9.76	2	0	0	0	0.04 +- 0.07	2	5 PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF03575 (2/2) Peptidase family S51 PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_groups_1347	2220.43 +- 119.57	2	0	0	0	0.01 +- 0.00	2	8 PF14081 (2/2) Domain of unknown function (DUF4262) PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like PF08666 (2/2) SAF domain PF07811 (2/2) TadE-like protein PF01476 (2/2) LysM domain PF01381 (2/2) Helix-turn-helix PF00482 (2/2) Type II secretion system (T2SS), protein F PF00437 (2/2) Type II/IV secretion system protein
precursor_groups_14643	660.47 +- 112.74	7	0	7	0	0.01 +- 0.01	7	15 TIGR01733 (7/7) amino acid adenylation domain PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain PF16197 (7/7) Ketoacyl-synthetase C-terminal extension PF13535 (7/7) ATP-grasp domain PF13193 (7/7) AMP-binding enzyme C-terminal domain PF12706 (7/7) Beta-lactamase superfamily domain PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain PF01636 (7/7) Phosphotransferase enzyme family PF00975 (7/7) Thioesterase domain PF00698 (7/7) Acyl transferase domain PF00668 (7/7) Condensation domain PF00550 (7/7) Phosphopantetheine attachment site PF00501 (7/7) AMP-binding enzyme PF00326 (7/7) Prolyl oligopeptidase family PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_6914	73.12 +- 24.38	2	0	0	0	0.03 +- 0.02	2	3 PF06912 (2/2) Protein of unknown function (DUF1275) PF02308 (2/2) MgtC family PF01566 (2/2) Natural resistance-associated macrophage protein
precursor_groups_10887	157.25 +- 62.23	4	0	2	0	0.07 +- 0.19	4	9 PF13191 (4/4) AAA ATPase domain PF10502 (4/4) Signal peptidase, peptidase S26 PF07291 (4/4) Methylamine utilisation protein MauE PF00717 (4/4) Peptidase S24-like PF00005 (4/4) ABC transporter PF02254 (3/4) TrkA-N domain PF01242 (3/4) 6-pyruvoyl tetrahydropterin synthase PF00664 (3/4) ABC transporter transmembrane region PF13181 (2/4) Tetratricopeptide repeat
precursor_groups_9177	91.00 +- 39.00	2	0	0	0	0.03 +- 0.02	2	2 PF03130 (2/2) PBS lyase HEAT-like repeat PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_groups_52435	1163.94 +- 693.66	2	0	0	0	0.02 +- 0.01	2	18 TIGR03561 (2/2) peroxiredoxin, Ohr subfamily PF13649 (2/2) Methyltransferase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF09339 (2/2) IclR helix-turn-helix domain PF09084 (2/2) NMT1/THI5 like PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF04199 (2/2) Putative cyclase PF03972 (2/2) MmgE/PrpD family PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family PF02566 (2/2) OsmC-like protein PF02515 (2/2) CoA-transferase family III PF01979 (2/2) Amidohydrolase family PF01614 (2/2) Bacterial transcriptional regulator PF01546 (2/2) Peptidase family M20/M25/M40 PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family PF00561 (2/2) alpha/beta hydrolase fold PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_groups_20284	98.93 +- 27.86	3	0	3	0	0.05 +- 0.05	3	6 PF18085 (3/3) Maltokinase N-terminal cap domain PF05547 (3/3) Immune inhibitor A peptidase M6 PF01433 (3/3) Peptidase family M1 domain PF08241 (2/3) Methyltransferase domain PF01183 (2/3) Glycosyl hydrolases family 25 PF00892 (2/3) EamA-like transporter family
precursor_groups_12012	858.49 +- 193.39	4	0	4	4	0.01 +- 0.00	4	11 TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein TIGR03605 (4/4) SagB-type dehydrogenase domain TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component PF13437 (4/4) HlyD family secretion protein PF03412 (4/4) Peptidase C39 family PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (4/4) Nitroreductase family PF00664 (4/4) ABC transporter transmembrane region PF00005 (4/4) ABC transporter
precursor_groups_68571	24.72 +- 1.08	2	0	0	0	0.08 +- 0.08	2	4 PF10923 (2/2) P-loop Domain of unknown function (DUF2791) PF09848 (2/2) Uncharacterized conserved protein (DUF2075) PF00271 (2/2) Helicase conserved C-terminal domain PF00270 (2/2) DEAD/DEAH box helicase
precursor_groups_1193	133.51 +- 85.83	9	0	0	0	0.03 +- 0.02	9	4 PF01471 (9/9) Putative peptidoglycan binding domain PF00561 (9/9) alpha/beta hydrolase fold PF08386 (8/9) TAP-like protein PF13515 (6/9) Fusaric acid resistance protein-like
precursor_groups_68779	362.00 +- 154.00	2	0	2	0	0.01 +- 0.01	2	2 PF08291 (2/2) Peptidase M15 PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_22154	1767.52 +- 216.09	3	0	1	3	0.01 +- 0.02	3	10 TIGR00702 (3/3) YcaO-type kinase domain PF13302 (3/3) Acetyltransferase (GNAT) domain PF08007 (3/3) Cupin superfamily protein PF07812 (3/3) TfuA-like protein PF07690 (3/3) Major Facilitator Superfamily PF05193 (3/3) Peptidase M16 inactive domain PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase PF00675 (3/3) Insulinase (Peptidase family M16) PF00326 (3/3) Prolyl oligopeptidase family
precursor_groups_170	250.91 +- 0.64	2	0	1	0	0.07 +- 0.08	2	42 PF13193 (2/2) AMP-binding enzyme C-terminal domain PF00501 (2/2) AMP-binding enzyme PF00171 (2/2) Aldehyde dehydrogenase family TIGR02258 (1/2) 2'-5' RNA ligase TIGR00517 (1/2) acyl carrier protein PF14310 (1/2) Fibronectin type III-like domain PF13802 (1/2) Galactose mutarotase-like PF13416 (1/2) Bacterial extracellular solute-binding protein PF13377 (1/2) Periplasmic binding protein-like domain PF08386 (1/2) TAP-like protein PF08240 (1/2) Alcohol dehydrogenase GroES-like domain PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF07883 (1/2) Cupin domain PF07690 (1/2) Major Facilitator Superfamily PF07555 (1/2) beta-N-acetylglucosaminidase PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF03422 (1/2) Carbohydrate binding module (family 6) PF02838 (1/2) Glycosyl hydrolase family 20, domain 2 PF02834 (1/2) LigT like Phosphoesterase PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain PF01636 (1/2) Phosphotransferase enzyme family PF01593 (1/2) Flavin containing amine oxidoreductase PF01381 (1/2) Helix-turn-helix PF01055 (1/2) Glycosyl hydrolases family 31 PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain PF00668 (1/2) Condensation domain PF00561 (1/2) alpha/beta hydrolase fold PF00550 (1/2) Phosphopantetheine attachment site PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00296 (1/2) Luciferase-like monooxygenase PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain PF00202 (1/2) Aminotransferase class-III PF00155 (1/2) Aminotransferase class I and II PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_174	500.84 +- 250.71	5	0	5	5	0.02 +- 0.05	5	11 TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM PF13575 (5/5) Domain of unknown function (DUF4135) PF13191 (5/5) AAA ATPase domain PF05147 (5/5) Lanthionine synthetase C-like protein PF03704 (5/5) Bacterial transcriptional activator domain PF00931 (5/5) NB-ARC domain PF00486 (5/5) Transcriptional regulatory protein, C terminal PF00196 (5/5) Bacterial regulatory proteins, luxR family PF13185 (4/5) GAF domain PF08448 (4/5) PAS fold PF07228 (4/5) Stage II sporulation protein E (SpoIIE)
precursor_groups_21393	152.71 +- 40.50	3	0	0	0	0.02 +- 0.01	3	3 PF07690 (3/3) Major Facilitator Superfamily PF01227 (3/3) GTP cyclohydrolase I PF00293 (3/3) NUDIX domain
precursor_groups_10707	221.77 +- 79.53	9	0	0	0	0.05 +- 0.04	9	10 TIGR00976 (9/9) hydrolase CocE/NonD family protein PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (9/9) alpha/beta hydrolase fold PF07690 (9/9) Major Facilitator Superfamily PF03781 (9/9) Sulfatase-modifying factor enzyme 1 PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (9/9) Phosphotriesterase family PF01494 (9/9) FAD binding domain PF00884 (9/9) Sulfatase PF00753 (9/9) Metallo-beta-lactamase superfamily
precursor_groups_48835	1029.17 +- 97.50	2	0	2	0	0.01 +- 0.01	2	11 PF12146 (2/2) Serine aminopeptidase, S33 PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport PF09924 (2/2) Uncharacterised conserved protein (DUF2156) PF08448 (2/2) PAS fold PF07993 (2/2) Male sterility protein PF07690 (2/2) Major Facilitator Superfamily PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport PF01613 (2/2) Flavin reductase like domain PF00899 (2/2) ThiF family PF00202 (2/2) Aminotransferase class-III PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_5265	2176.88 +- 2360.36	4	0	4	4	0.01 +- 0.01	4	8 TIGR03897 (4/4) type 2 lantibiotic biosynthesis protein LanM PF14867 (4/4) Lantibiotic alpha PF13575 (4/4) Domain of unknown function (DUF4135) PF05147 (4/4) Lanthionine synthetase C-like protein PF03412 (4/4) Peptidase C39 family PF00664 (4/4) ABC transporter transmembrane region PF00005 (4/4) ABC transporter PF00296 (3/4) Luciferase-like monooxygenase
precursor_groups_2240	250.40 +- 9.60	2	0	0	0	0.02 +- 0.02	2	4 PF13365 (2/2) Trypsin-like peptidase domain PF00400 (2/2) WD domain, G-beta repeat PF00248 (2/2) Aldo/keto reductase family PF07721 (1/2) Tetratricopeptide repeat
precursor_groups_2244	196.89 +- 6.51	4	0	0	0	0.04 +- 0.15	4	16 TIGR01558 (4/4) putative phage terminase, small subunit, P27 family TIGR01554 (4/4) phage major capsid protein, HK97 family TIGR01543 (4/4) phage prohead protease, HK97 family TIGR01537 (4/4) phage portal protein, HK97 family PF16945 (4/4) Putative lactococcus lactis phage r1t holin PF13229 (4/4) Right handed beta helix region PF10145 (4/4) Phage-related minor tail protein PF05119 (4/4) Phage terminase, small subunit PF05065 (4/4) Phage capsid family PF04860 (4/4) Phage portal protein PF04586 (4/4) Caudovirus prohead serine protease PF03354 (4/4) Phage Terminase PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase PF01476 (4/4) LysM domain PF01464 (4/4) Transglycosylase SLT domain PF01381 (4/4) Helix-turn-helix
precursor_groups_19605	157.71 +- 71.71	2	0	2	0	0.04 +- 0.08	2	9 TIGR01733 (2/2) amino acid adenylation domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12146 (2/2) Serine aminopeptidase, S33 PF07690 (2/2) Major Facilitator Superfamily PF01425 (2/2) Amidase PF01042 (2/2) Endoribonuclease L-PSP PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme
precursor_groups_450	27.25 +- 2.74	9	0	3	0	0.07 +- 0.09	9	6 PF13244 (9/9) Domain of unknown function (DUF4040) PF12840 (9/9) Helix-turn-helix domain PF04066 (9/9) Multiple resistance and pH regulation protein F (MrpF / PhaF) PF04039 (9/9) Domain related to MnhB subunit of Na+/H+ antiporter PF00420 (9/9) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PF00361 (9/9) Proton-conducting membrane transporter
precursor_groups_43009	109.51 +- 1.92	2	0	0	0	0.04 +- 0.03	2	6 PF04167 (2/2) Protein of unknown function (DUF402) PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF02225 (2/2) PA domain PF01978 (2/2) Sugar-specific transcriptional regulator TrmB PF00144 (2/2) Beta-lactamase PF00082 (2/2) Subtilase family
precursor_groups_108	126.20 +- 2.80	2	0	1	0	0.05 +- 0.05	2	16 PF13088 (2/2) BNR repeat-like domain TIGR03444 (1/2) ergothioneine biosynthesis glutamate--cysteine ligase EgtA TIGR03026 (1/2) nucleotide sugar dehydrogenase PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF13641 (1/2) Glycosyltransferase like family 2 PF13620 (1/2) Carboxypeptidase regulatory-like domain PF13520 (1/2) Amino acid permease PF11695 (1/2) Domain of unknown function (DUF3291) PF04978 (1/2) Protein of unknown function (DUF664) PF04264 (1/2) YceI-like domain PF04248 (1/2) Domain of unknown function (DUF427) PF04237 (1/2) YjbR PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2) PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
precursor_groups_6137	726.94 +- 148.59	6	0	0	0	0.02 +- 0.02	6	7 PF17914 (6/6) HopA1 effector protein family PF13649 (6/6) Methyltransferase domain PF05193 (6/6) Peptidase M16 inactive domain PF02441 (6/6) Flavoprotein PF00675 (6/6) Insulinase (Peptidase family M16) PF00296 (6/6) Luciferase-like monooxygenase PF00005 (6/6) ABC transporter
precursor_groups_513	297.75 +- 125.22	3	0	0	3	0.02 +- 0.03	3	10 TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE PF13186 (3/3) Iron-sulfur cluster-binding domain PF12706 (3/3) Beta-lactamase superfamily domain PF07995 (3/3) Glucose / Sorbosone dehydrogenase PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (3/3) Radical SAM superfamily PF03070 (3/3) TENA/THI-4/PQQC family TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA
precursor_groups_31875	152.80 +- 39.15	3	0	0	0	0.03 +- 0.02	3	7 PF13377 (3/3) Periplasmic binding protein-like domain PF13185 (3/3) GAF domain PF08448 (3/3) PAS fold PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (3/3) Xylose isomerase-like TIM barrel PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_groups_100	634.11 +- 416.96	8	0	5	8	0.05 +- 0.08	8	21 TIGR04364 (8/8) methyltransferase, FxLD system TIGR04363 (8/8) FxLD family lantipeptide TIGR03891 (8/8) thiopeptide-type bacteriocin biosynthesis domain PF14028 (8/8) Lantibiotic biosynthesis dehydratase C-term PF05147 (8/8) Lanthionine synthetase C-like protein PF04738 (8/8) Lantibiotic dehydratase, N terminus PF01135 (8/8) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF05331 (7/8) Protein of unknown function (DUF742) PF03259 (7/8) Roadblock/LC7 domain PF03029 (7/8) Conserved hypothetical ATP binding protein PF01427 (7/8) D-ala-D-ala dipeptidase PF00293 (7/8) NUDIX domain PF00196 (7/8) Bacterial regulatory proteins, luxR family PF00005 (7/8) ABC transporter PF02771 (5/8) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (5/8) Acyl-CoA dehydrogenase, middle domain PF01590 (5/8) GAF domain PF00723 (5/8) Glycosyl hydrolases family 15 PF00441 (5/8) Acyl-CoA dehydrogenase, C-terminal domain PF13671 (4/8) AAA domain PF02518 (4/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
precursor_groups_22572	473.90 +- 383.28	4	0	4	0	0.06 +- 0.20	4	17 TIGR01509 (4/4) HAD hydrolase, family IA, variant 3 PF13632 (4/4) Glycosyl transferase family group 2 PF13419 (4/4) Haloacid dehalogenase-like hydrolase PF13191 (4/4) AAA ATPase domain PF12710 (4/4) haloacid dehalogenase-like hydrolase PF07690 (4/4) Major Facilitator Superfamily PF04321 (4/4) RmlD substrate binding domain PF01979 (4/4) Amidohydrolase family PF00535 (4/4) Glycosyl transferase family 2 PF00480 (4/4) ROK family PF00459 (4/4) Inositol monophosphatase family PF00294 (4/4) pfkB family carbohydrate kinase PF00202 (4/4) Aminotransferase class-III PF00196 (4/4) Bacterial regulatory proteins, luxR family TIGR00178 (3/4) isocitrate dehydrogenase, NADP-dependent PF03971 (3/4) Monomeric isocitrate dehydrogenase PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_1833	328.63 +- 21.56	3	0	3	3	0.03 +- 0.03	3	4 PF13471 (3/3) Transglutaminase-like superfamily PF01546 (3/3) Peptidase family M20/M25/M40 PF00733 (3/3) Asparagine synthase PF00005 (3/3) ABC transporter
precursor_groups_298	359.72 +- 141.51	6	0	0	0	0.02 +- 0.04	6	6 PF07739 (6/6) TipAS antibiotic-recognition domain PF07690 (6/6) Major Facilitator Superfamily PF07228 (6/6) Stage II sporulation protein E (SpoIIE) PF00291 (6/6) Pyridoxal-phosphate dependent enzyme PF13411 (5/6) MerR HTH family regulatory protein PF01551 (5/6) Peptidase family M23
precursor_groups_3023	325.00 +- 239.00	3	0	0	0	0.03 +- 0.08	3	3 PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01145 (3/3) SPFH domain / Band 7 family PF00877 (3/3) NlpC/P60 family
precursor_groups_295	1775.87 +- 1261.12	4	0	3	4	0.04 +- 0.14	4	8 PF13649 (4/4) Methyltransferase domain PF12730 (4/4) ABC-2 family transporter protein PF00465 (4/4) Iron-containing alcohol dehydrogenase PF00296 (4/4) Luciferase-like monooxygenase PF00202 (4/4) Aminotransferase class-III PF00069 (4/4) Protein kinase domain PF00005 (4/4) ABC transporter PF05147 (3/4) Lanthionine synthetase C-like protein
precursor_groups_26658	516.88 +- 343.12	2	0	2	0	0.04 +- 0.11	2	19 TIGR01733 (2/2) amino acid adenylation domain TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720 TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit TIGR00169 (2/2) 3-isopropylmalate dehydrogenase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF11806 (2/2) Domain of unknown function (DUF3327) PF08242 (2/2) Methyltransferase domain PF03621 (2/2) MbtH-like protein PF00756 (2/2) Putative esterase PF00694 (2/2) Aconitase C-terminal domain PF00682 (2/2) HMGL-like PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00330 (2/2) Aconitase family (aconitate hydratase) PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase PF00155 (2/2) Aminotransferase class I and II
precursor_groups_67341	447.87 +- 22.41	2	0	0	0	0.04 +- 0.02	2	16 TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF08443 (2/2) RimK-like ATP-grasp domain PF07690 (2/2) Major Facilitator Superfamily PF02779 (2/2) Transketolase, pyrimidine binding domain PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (2/2) Amino acid kinase family PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_5466	48.84 +- 15.40	2	0	0	0	0.09 +- 0.08	2	8 TIGR00072 (2/2) hydrogenase maturation protease PF17179 (2/2) 4Fe-4S dicluster domain PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PF01750 (2/2) Hydrogenase maturation protease PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit PF00374 (2/2) Nickel-dependent hydrogenase PF00175 (2/2) Oxidoreductase NAD-binding domain PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_groups_84495	1040.00 +- 0.00	2	0	0	2	0.01 +- 0.00	2	6 TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF07690 (2/2) Major Facilitator Superfamily PF05193 (2/2) Peptidase M16 inactive domain PF03358 (2/2) NADPH-dependent FMN reductase PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_groups_84497	4695.60 +- 0.00	2	0	2	2	0.01 +- 0.00	2	11 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01189 (2/2) heme ABC exporter, ATP-binding protein CcmA PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF12698 (2/2) ABC-2 family transporter protein PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF04738 (2/2) Lantibiotic dehydratase, N terminus PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (2/2) Nitroreductase family PF00005 (2/2) ABC transporter
precursor_groups_58293	961.71 +- 70.29	2	0	2	0	0.01 +- 0.00	2	8 PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF08386 (2/2) TAP-like protein PF07732 (2/2) Multicopper oxidase PF07731 (2/2) Multicopper oxidase PF07676 (2/2) WD40-like Beta Propeller Repeat PF01979 (2/2) Amidohydrolase family PF00561 (2/2) alpha/beta hydrolase fold PF00394 (2/2) Multicopper oxidase
precursor_groups_2742	187.56 +- 79.93	4	0	0	0	0.03 +- 0.04	4	5 PF06628 (4/4) Catalase-related immune-responsive PF01475 (4/4) Ferric uptake regulator family PF00248 (4/4) Aldo/keto reductase family PF00199 (4/4) Catalase PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
precursor_groups_48573	3194.97 +- 210.63	2	0	0	0	0.02 +- 0.01	2	13 TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (2/2) ATP-grasp domain PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (2/2) Prephenate dehydrogenase PF01613 (2/2) Flavin reductase like domain PF01070 (2/2) FMN-dependent dehydrogenase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (2/2) Luciferase-like monooxygenase PF00155 (2/2) Aminotransferase class I and II PF00106 (2/2) short chain dehydrogenase
precursor_groups_65596	175.06 +- 37.41	2	0	0	0	0.03 +- 0.04	2	9 TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain PF13399 (2/2) LytR cell envelope-related transcriptional attenuator PF07859 (2/2) alpha/beta hydrolase fold PF03816 (2/2) Cell envelope-related transcriptional attenuator domain PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase PF00459 (2/2) Inositol monophosphatase family PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_groups_11811	125.11 +- 36.14	2	0	0	0	0.05 +- 0.06	2	13 TIGR01180 (2/2) putative alpha-1,2-mannosidase PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain PF07971 (2/2) Glycosyl hydrolase family 92 PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00672 (2/2) HAMP domain PF00553 (2/2) Cellulose binding domain PF00512 (2/2) His Kinase A (phospho-acceptor) domain TIGR01766 (1/2) transposase, IS605 OrfB family PF07282 (1/2) Putative transposase DNA-binding domain PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01385 (1/2) Probable transposase PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00072 (1/2) Response regulator receiver domain
precursor_groups_68952	961.71 +- 70.29	2	0	2	0	0.01 +- 0.00	2	8 PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF08386 (2/2) TAP-like protein PF07732 (2/2) Multicopper oxidase PF07731 (2/2) Multicopper oxidase PF07676 (2/2) WD40-like Beta Propeller Repeat PF01979 (2/2) Amidohydrolase family PF00561 (2/2) alpha/beta hydrolase fold PF00394 (2/2) Multicopper oxidase
precursor_groups_7713	125.11 +- 36.14	2	0	0	0	0.05 +- 0.06	2	13 TIGR01180 (2/2) putative alpha-1,2-mannosidase PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain PF07971 (2/2) Glycosyl hydrolase family 92 PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00672 (2/2) HAMP domain PF00553 (2/2) Cellulose binding domain PF00512 (2/2) His Kinase A (phospho-acceptor) domain TIGR01766 (1/2) transposase, IS605 OrfB family PF07282 (1/2) Putative transposase DNA-binding domain PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01385 (1/2) Probable transposase PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00072 (1/2) Response regulator receiver domain
precursor_groups_14797	47.52 +- 9.22	3	0	0	0	0.04 +- 0.05	3	3 PF09586 (3/3) Bacterial membrane protein YfhO PF04138 (3/3) GtrA-like protein PF00535 (3/3) Glycosyl transferase family 2
precursor_groups_69133	647.50 +- 2.50	2	0	0	0	0.01 +- 0.00	2	10 TIGR03923 (2/2) type VII secretion protein EccE TIGR03921 (2/2) type VII secretion-associated serine protease mycosin TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE PF04545 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF03640 (2/2) Secreted repeat of unknown function PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily PF00082 (2/2) Subtilase family
precursor_groups_11727	272.98 +- 0.99	3	0	3	0	0.09 +- 0.18	3	11 TIGR03797 (3/3) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (3/3) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport PF07690 (3/3) Major Facilitator Superfamily PF05013 (3/3) N-formylglutamate amidohydrolase PF03412 (3/3) Peptidase C39 family PF03055 (3/3) Retinal pigment epithelial membrane protein PF00664 (3/3) ABC transporter transmembrane region PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00005 (3/3) ABC transporter PF13437 (2/3) HlyD family secretion protein
precursor_groups_73777	149.12 +- 39.59	2	0	0	0	0.06 +- 0.02	2	7 PF16353 (2/2) Domain of unknown function(DUF4981) PF02929 (2/2) Beta galactosidase small chain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain PF01547 (2/2) Bacterial extracellular solute-binding protein PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_groups_49943	347.93 +- 153.74	2	0	2	2	0.05 +- 0.08	2	10 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_groups_639	398.21 +- 55.58	6	0	6	6	0.07 +- 0.08	6	12 TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (6/6) SagB-type dehydrogenase domain TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF13191 (6/6) AAA ATPase domain PF04738 (6/6) Lantibiotic dehydratase, N terminus PF03704 (6/6) Bacterial transcriptional activator domain PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (6/6) ABC-2 type transporter PF00881 (6/6) Nitroreductase family PF00486 (6/6) Transcriptional regulatory protein, C terminal PF00005 (6/6) ABC transporter
precursor_groups_12109	150.50 +- 136.83	4	0	0	0	0.03 +- 0.02	4	3 PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase PF00067 (4/4) Cytochrome P450 PF03745 (2/4) Domain of unknown function (DUF309)
precursor_groups_61909	773.17 +- 20.67	2	0	0	0	0.01 +- 0.00	2	8 TIGR01926 (2/2) uncharacterized peroxidase-related enzyme PF13454 (2/2) FAD-NAD(P)-binding PF13343 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF02627 (2/2) Carboxymuconolactone decarboxylase family PF01244 (2/2) Membrane dipeptidase (Peptidase family M19) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_groups_35315	582.00 +- 192.00	2	0	0	0	0.01 +- 0.01	2	10 PF13191 (2/2) AAA ATPase domain PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif PF05345 (2/2) Putative Ig domain PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain PF02225 (2/2) PA domain PF01638 (2/2) HxlR-like helix-turn-helix PF01483 (2/2) Proprotein convertase P-domain PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00082 (2/2) Subtilase family
precursor_groups_25675	172.00 +- 60.81	3	0	0	0	0.01 +- 0.00	3	2 PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF00107 (3/3) Zinc-binding dehydrogenase
precursor_groups_9823	404.91 +- 183.77	2	0	0	2	0.07 +- 0.11	2	18 PF18604 (2/2) Pre ATP-grasp domain PF18105 (2/2) PGM1 C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF04055 (2/2) Radical SAM superfamily TIGR01249 (1/2) prolyl aminopeptidase PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096) PF07366 (1/2) SnoaL-like polyketide cyclase PF04203 (1/2) Sortase domain PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF01610 (1/2) Transposase PF01381 (1/2) Helix-turn-helix PF00672 (1/2) HAMP domain PF00583 (1/2) Acetyltransferase (GNAT) family PF00561 (1/2) alpha/beta hydrolase fold PF00512 (1/2) His Kinase A (phospho-acceptor) domain PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00400 (1/2) WD domain, G-beta repeat PF00072 (1/2) Response regulator receiver domain
precursor_groups_84405	1105.00 +- 0.00	2	0	0	0	0.02 +- 0.00	2	13 PF16353 (2/2) Domain of unknown function(DUF4981) PF13378 (2/2) Enolase C-terminal domain-like PF13377 (2/2) Periplasmic binding protein-like domain PF06452 (2/2) Carbohydrate family 9 binding domain-like PF02929 (2/2) Beta galactosidase small chain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_23621	394.50 +- 74.31	5	0	0	0	0.02 +- 0.03	5	6 PF08386 (5/5) TAP-like protein PF07690 (5/5) Major Facilitator Superfamily PF01979 (5/5) Amidohydrolase family PF00561 (5/5) alpha/beta hydrolase fold PF00326 (5/5) Prolyl oligopeptidase family PF13649 (3/5) Methyltransferase domain
precursor_groups_4069	27.10 +- 6.92	3	0	0	0	0.08 +- 0.07	3	3 TIGR01249 (3/3) prolyl aminopeptidase PF07470 (3/3) Glycosyl Hydrolase Family 88 PF00561 (3/3) alpha/beta hydrolase fold
precursor_groups_52985	91.60 +- 0.33	2	0	2	0	0.10 +- 0.29	2	17 TIGR01733 (2/2) amino acid adenylation domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF05977 (2/2) Transmembrane secretion effector PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01842 (2/2) ACT domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00975 (2/2) Thioesterase domain PF00742 (2/2) Homoserine dehydrogenase PF00698 (2/2) Acyl transferase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00067 (2/2) Cytochrome P450
precursor_groups_1547	2852.98 +- 1813.19	13	8	5	13	0.01 +- 0.01	5	9 TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (12/13) Nitroreductase family TIGR03605 (11/13) SagB-type dehydrogenase domain PF04738 (10/13) Lantibiotic dehydratase, N terminus PF00067 (8/13) Cytochrome P450 PF00440 (7/13) Bacterial regulatory proteins, tetR family
precursor_groups_16719	137.60 +- 68.80	2	0	0	0	0.06 +- 0.05	2	8 PF14864 (2/2) Alkyl sulfatase C-terminal PF14863 (2/2) Alkyl sulfatase dimerisation PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF00753 (2/2) Metallo-beta-lactamase superfamily PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_52076	139.98 +- 39.33	2	0	0	0	0.04 +- 0.04	2	6 PF07702 (2/2) UTRA domain PF04672 (2/2) S-adenosyl methyltransferase PF03747 (2/2) ADP-ribosylglycohydrolase PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_50588	250.40 +- 9.60	2	0	0	0	0.02 +- 0.02	2	4 PF13365 (2/2) Trypsin-like peptidase domain PF00400 (2/2) WD domain, G-beta repeat PF00248 (2/2) Aldo/keto reductase family PF07721 (1/2) Tetratricopeptide repeat
precursor_groups_71689	344.00 +- 0.00	2	0	0	0	0.03 +- 0.02	2	5 PF07690 (2/2) Major Facilitator Superfamily PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA) PF00561 (2/2) alpha/beta hydrolase fold PF00296 (2/2) Luciferase-like monooxygenase PF00106 (2/2) short chain dehydrogenase
precursor_groups_74379	3120.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	13 TIGR04245 (2/2) N-acyltransferase NodA TIGR04243 (2/2) chitooligosaccharide deacetylase NodB TIGR04242 (2/2) chitooligosaccharide synthase NodC TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02474 (2/2) Nodulation protein A (NodA) PF01522 (2/2) Polysaccharide deacetylase PF01061 (2/2) ABC-2 type transporter PF00535 (2/2) Glycosyl transferase family 2 PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (2/2) ABC transporter
precursor_groups_63001	105.74 +- 24.26	2	0	0	0	0.03 +- 0.03	2	3 PF07690 (2/2) Major Facilitator Superfamily PF01255 (2/2) Putative undecaprenyl diphosphate synthase PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_groups_1380	744.35 +- 495.10	3	0	2	3	0.02 +- 0.02	3	25 TIGR04504 (3/3) SDR family mycofactocin-dependent oxidoreductase TIGR03969 (3/3) mycofactocin precursor TIGR03967 (3/3) putative mycofactocin binding protein MftB TIGR03966 (3/3) heme/flavin dehydrogenase, mycofactocin system TIGR03965 (3/3) mycofactocin system glycosyltransferase TIGR03964 (3/3) mycofactocin system creatininase family protein TIGR03962 (3/3) mycofactocin radical SAM maturase PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF13186 (3/3) Iron-sulfur cluster-binding domain PF04055 (3/3) Radical SAM superfamily PF02633 (3/3) Creatinine amidohydrolase PF01070 (3/3) FMN-dependent dehydrogenase PF00535 (3/3) Glycosyl transferase family 2 PF17676 (2/3) LD-carboxypeptidase C-terminal domain PF16861 (2/3) Carbamoyltransferase C-terminus PF13489 (2/3) Methyltransferase domain PF08242 (2/3) Methyltransferase domain PF03129 (2/3) Anticodon binding domain PF02543 (2/3) Carbamoyltransferase N-terminus PF02016 (2/3) LD-carboxypeptidase N-terminal domain PF01980 (2/3) tRNA-methyltransferase O PF01041 (2/3) DegT/DnrJ/EryC1/StrS aminotransferase family PF00587 (2/3) tRNA synthetase class II core domain (G, H, P, S and T) PF00152 (2/3) tRNA synthetases class II (D, K and N) PF00067 (2/3) Cytochrome P450
precursor_groups_25018	212.38 +- 67.73	3	0	3	3	0.04 +- 0.06	3	11 TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1 TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family PF10025 (3/3) Uncharacterized conserved protein (DUF2267) PF08281 (3/3) Sigma-70, region 4 PF07690 (3/3) Major Facilitator Superfamily PF04542 (3/3) Sigma-70 region 2 PF04055 (3/3) Radical SAM superfamily PF02310 (3/3) B12 binding domain PF00355 (3/3) Rieske [2Fe-2S] domain PF00326 (3/3) Prolyl oligopeptidase family PF00067 (3/3) Cytochrome P450
precursor_groups_6246	1991.35 +- 896.21	5	0	5	0	0.02 +- 0.10	5	34 TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (5/5) diaminopimelate epimerase PF18603 (5/5) L-amino acid ligase C-terminal domain 2 PF18130 (5/5) ATP-grasp N-terminal domain PF14518 (5/5) Iron-containing redox enzyme PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal PF13535 (5/5) ATP-grasp domain PF13458 (5/5) Periplasmic binding protein PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter PF10014 (5/5) 2OG-Fe dioxygenase PF08241 (5/5) Methyltransferase domain PF07859 (5/5) alpha/beta hydrolase fold PF07690 (5/5) Major Facilitator Superfamily PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (5/5) Aminopeptidase P, N-terminal domain PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily PF02653 (5/5) Branched-chain amino acid transport system / permease component PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family PF02153 (5/5) Prephenate dehydrogenase PF01678 (5/5) Diaminopimelate epimerase PF01575 (5/5) MaoC like domain PF01568 (5/5) Molydopterin dinucleotide binding domain PF01425 (5/5) Amidase PF01070 (5/5) FMN-dependent dehydrogenase PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (5/5) EamA-like transporter family PF00682 (5/5) HMGL-like PF00557 (5/5) Metallopeptidase family M24 PF00384 (5/5) Molybdopterin oxidoreductase PF00248 (5/5) Aldo/keto reductase family PF00155 (5/5) Aminotransferase class I and II PF00005 (5/5) ABC transporter
precursor_groups_20824	1582.13 +- 391.36	2	0	2	0	0.03 +- 0.04	2	28 TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family TIGR01746 (2/2) thioester reductase domain TIGR01733 (2/2) amino acid adenylation domain TIGR01525 (2/2) heavy metal translocating P-type ATPase TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (2/2) AMP-binding enzyme C-terminal domain PF10862 (2/2) FcoT-like thioesterase domain PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08281 (2/2) Sigma-70, region 4 PF07993 (2/2) Male sterility protein PF07690 (2/2) Major Facilitator Superfamily PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (2/2) Sigma-70 region 2 PF04314 (2/2) Copper chaperone PCu(A)C PF03929 (2/2) PepSY-associated TM region PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (2/2) DJ-1/PfpI family PF01794 (2/2) Ferric reductase like transmembrane component PF01497 (2/2) Periplasmic binding protein PF01032 (2/2) FecCD transport family PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00403 (2/2) Heavy-metal-associated domain PF00122 (2/2) E1-E2 ATPase PF00005 (2/2) ABC transporter
precursor_groups_10459	128.12 +- 45.26	4	0	4	0	0.08 +- 0.18	4	20 TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (4/4) amino acid adenylation domain PF16197 (4/4) Ketoacyl-synthetase C-terminal extension PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13193 (4/4) AMP-binding enzyme C-terminal domain PF07690 (4/4) Major Facilitator Superfamily PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02127 (4/4) Aminopeptidase I zinc metalloprotease (M18) PF00975 (4/4) Thioesterase domain PF00877 (4/4) NlpC/P60 family PF00698 (4/4) Acyl transferase domain PF00668 (4/4) Condensation domain PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00296 (4/4) Luciferase-like monooxygenase PF00202 (4/4) Aminotransferase class-III PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain PF12158 (2/4) Protein of unknown function (DUF3592) PF01145 (2/4) SPFH domain / Band 7 family
precursor_groups_22684	618.09 +- 123.82	5	0	5	5	0.01 +- 0.02	5	15 TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase PF17676 (5/5) LD-carboxypeptidase C-terminal domain PF16715 (5/5) Cyclodipeptide synthase PF13847 (5/5) Methyltransferase domain PF13576 (5/5) Pentapeptide repeats (9 copies) PF13535 (5/5) ATP-grasp domain PF07690 (5/5) Major Facilitator Superfamily PF04055 (5/5) Radical SAM superfamily PF02310 (5/5) B12 binding domain PF02016 (5/5) LD-carboxypeptidase N-terminal domain PF01636 (5/5) Phosphotransferase enzyme family PF00196 (5/5) Bacterial regulatory proteins, luxR family PF00155 (5/5) Aminotransferase class I and II PF00152 (5/5) tRNA synthetases class II (D, K and N) PF00067 (5/5) Cytochrome P450
precursor_groups_37828	760.47 +- 374.44	3	0	0	0	0.04 +- 0.12	3	26 TIGR03567 (3/3) FMN reductase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain PF14559 (3/3) Tetratricopeptide repeat PF13535 (3/3) ATP-grasp domain PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring) PF13432 (3/3) Tetratricopeptide repeat PF13424 (3/3) Tetratricopeptide repeat PF07690 (3/3) Major Facilitator Superfamily PF03358 (3/3) NADPH-dependent FMN reductase PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF01613 (3/3) Flavin reductase like domain PF00326 (3/3) Prolyl oligopeptidase family PF00294 (3/3) pfkB family carbohydrate kinase TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family PF09334 (2/3) tRNA synthetases class I (M) PF08281 (2/3) Sigma-70, region 4 PF07883 (2/3) Cupin domain PF04542 (2/3) Sigma-70 region 2 PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02142 (2/3) MGS-like domain PF01808 (2/3) AICARFT/IMPCHase bienzyme PF00709 (2/3) Adenylosuccinate synthetase PF00355 (2/3) Rieske [2Fe-2S] domain PF00202 (2/3) Aminotransferase class-III
precursor_groups_5898	203.13 +- 221.37	6	0	4	0	0.05 +- 0.10	6	6 PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase PF04324 (6/6) BFD-like [2Fe-2S] binding domain PF02782 (6/6) FGGY family of carbohydrate kinases, C-terminal domain PF01266 (6/6) FAD dependent oxidoreductase PF00370 (6/6) FGGY family of carbohydrate kinases, N-terminal domain PF00293 (4/6) NUDIX domain
precursor_groups_25793	694.47 +- 44.47	2	0	2	2	0.01 +- 0.00	2	9 TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1 PF13649 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF05193 (2/2) Peptidase M16 inactive domain PF04989 (2/2) Cephalosporin hydroxylase PF04055 (2/2) Radical SAM superfamily PF02310 (2/2) B12 binding domain PF00805 (2/2) Pentapeptide repeats (8 copies) PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_groups_76314	100.28 +- 9.84	2	0	0	0	0.06 +- 0.06	2	6 PF14903 (2/2) WG containing repeat PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase PF00950 (2/2) ABC 3 transport family PF00583 (2/2) Acetyltransferase (GNAT) family PF00005 (2/2) ABC transporter
precursor_groups_25791	685.57 +- 53.59	4	0	3	0	0.07 +- 0.22	4	19 TIGR01525 (4/4) heavy metal translocating P-type ATPase TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF13549 (4/4) ATP-grasp domain PF13535 (4/4) ATP-grasp domain PF13480 (4/4) Acetyltransferase (GNAT) domain PF13115 (4/4) YtkA-like PF04389 (4/4) Peptidase family M28 PF02627 (4/4) Carboxymuconolactone decarboxylase family PF01676 (4/4) Metalloenzyme superfamily PF00702 (4/4) haloacid dehalogenase-like hydrolase PF00664 (4/4) ABC transporter transmembrane region PF00403 (4/4) Heavy-metal-associated domain PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00155 (4/4) Aminotransferase class I and II PF00122 (4/4) E1-E2 ATPase PF00117 (4/4) Glutamine amidotransferase class-I PF00005 (4/4) ABC transporter PF02222 (2/4) ATP-grasp domain
precursor_groups_63090	237.03 +- 98.37	2	0	0	0	0.02 +- 0.04	2	9 TIGR03930 (2/2) WXG100 family type VII secretion target TIGR03920 (2/2) type VII secretion integral membrane protein EccD TIGR03919 (2/2) type VII secretion protein EccB PF15644 (2/2) Papain fold toxin 1, glutamine deamidase PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD PF06013 (2/2) Proteins of 100 residues with WXG PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_groups_83681	702.33 +- 200.67	2	0	0	0	0.01 +- 0.00	2	12 TIGR00556 (2/2) phosphopantetheine--protein transferase domain TIGR00027 (2/2) methyltransferase, TIGR00027 family PF12706 (2/2) Beta-lactamase superfamily domain PF11583 (2/2) P-aminobenzoate N-oxygenase AurF PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180) PF07690 (2/2) Major Facilitator Superfamily PF06628 (2/2) Catalase-related immune-responsive PF04072 (2/2) Leucine carboxyl methyltransferase PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF01575 (2/2) MaoC like domain PF00550 (2/2) Phosphopantetheine attachment site PF00199 (2/2) Catalase
precursor_groups_56850	146.32 +- 79.43	2	0	0	2	0.04 +- 0.06	2	7 TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family TIGR04186 (2/2) putative ATP-grasp target RiPP TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family PF07702 (2/2) UTRA domain PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_6965	216.00 +- 44.00	2	0	0	0	0.03 +- 0.04	2	4 TIGR01910 (2/2) peptidase, ArgE/DapE family PF01546 (2/2) Peptidase family M20/M25/M40 PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase PF00107 (1/2) Zinc-binding dehydrogenase
precursor_groups_9048	119.08 +- 0.00	2	0	0	0	0.03 +- 0.01	2	6 TIGR03930 (2/2) WXG100 family type VII secretion target TIGR03921 (2/2) type VII secretion-associated serine protease mycosin TIGR03919 (2/2) type VII secretion protein EccB PF06013 (2/2) Proteins of 100 residues with WXG PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B PF00082 (2/2) Subtilase family
precursor_groups_46472	300.06 +- 213.54	3	0	0	0	0.04 +- 0.05	3	7 PF17900 (3/3) Peptidase M1 N-terminal domain PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family PF01965 (3/3) DJ-1/PfpI family PF01433 (3/3) Peptidase family M1 domain PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00082 (3/3) Subtilase family
precursor_groups_2839	56.37 +- 16.27	3	0	0	0	0.08 +- 0.07	3	4 TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF07690 (3/3) Major Facilitator Superfamily PF00296 (3/3) Luciferase-like monooxygenase PF00106 (3/3) short chain dehydrogenase
precursor_groups_10786	234.57 +- 34.56	3	0	0	0	0.01 +- 0.00	3	4 PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif PF03713 (3/3) Domain of unknown function (DUF305) PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
precursor_groups_72732	461.05 +- 11.67	2	0	0	0	0.04 +- 0.01	2	17 TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF08443 (2/2) RimK-like ATP-grasp domain PF07690 (2/2) Major Facilitator Superfamily PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF02779 (2/2) Transketolase, pyrimidine binding domain PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01370 (2/2) NAD dependent epimerase/dehydratase family PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (2/2) Amino acid kinase family PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
precursor_groups_3163	322.50 +- 64.50	2	0	0	0	0.01 +- 0.00	2	7 PF17964 (1/2) Bacterial Ig domain PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252) PF04672 (1/2) S-adenosyl methyltransferase PF03734 (1/2) L,D-transpeptidase catalytic domain PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_2844	37.67 +- 9.91	8	0	0	0	0.06 +- 0.08	8	5 PF17866 (8/8) AAA lid domain PF13229 (8/8) Right handed beta helix region PF00652 (8/8) Ricin-type beta-trefoil lectin domain PF00082 (8/8) Subtilase family PF00004 (8/8) ATPase family associated with various cellular activities (AAA)
precursor_groups_50774	1057.64 +- 490.36	2	0	2	2	0.01 +- 0.02	2	9 TIGR04353 (2/2) PqqD family protein, HPr-rel-A system PF13646 (2/2) HEAT repeats PF13471 (2/2) Transglutaminase-like superfamily PF13411 (2/2) MerR HTH family regulatory protein PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (2/2) Asparagine synthase PF00664 (2/2) ABC transporter transmembrane region PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter
precursor_groups_77287	476.67 +- 43.33	2	0	0	0	0.01 +- 0.00	2	3 PF18029 (2/2) Glyoxalase-like domain PF07690 (2/2) Major Facilitator Superfamily PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_19328	388.80 +- 1.47	5	0	0	0	0.01 +- 0.00	5	3 PF07690 (5/5) Major Facilitator Superfamily PF01425 (5/5) Amidase PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
precursor_groups_1879	104.64 +- 38.90	15	0	0	0	0.06 +- 0.07	15	9 PF14158 (15/15) YndJ-like protein PF13581 (15/15) Histidine kinase-like ATPase domain PF13492 (15/15) GAF domain PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain PF09348 (15/15) Domain of unknown function (DUF1990) PF08447 (15/15) PAS fold PF07228 (15/15) Stage II sporulation protein E (SpoIIE) PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase PF00149 (15/15) Calcineurin-like phosphoesterase
precursor_groups_47870	249.70 +- 143.29	3	0	0	0	0.05 +- 0.05	3	18 TIGR03425 (3/3) urea carboxylase-associated protein 2 TIGR03424 (3/3) urea carboxylase-associated protein 1 TIGR02712 (3/3) urea carboxylase TIGR01930 (3/3) acetyl-CoA C-acyltransferase TIGR01509 (3/3) HAD hydrolase, family IA, variant 3 PF13520 (3/3) Amino acid permease PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF09347 (3/3) Domain of unknown function (DUF1989) PF02803 (3/3) Thiolase, C-terminal domain PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain PF02785 (3/3) Biotin carboxylase C-terminal domain PF02682 (3/3) Carboxyltransferase domain, subdomain C and D PF02626 (3/3) Carboxyltransferase domain, subdomain A and B PF01425 (3/3) Amidase PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00364 (3/3) Biotin-requiring enzyme PF00289 (3/3) Biotin carboxylase, N-terminal domain PF00108 (3/3) Thiolase, N-terminal domain
precursor_groups_44302	260.13 +- 5.78	2	0	0	0	0.02 +- 0.01	2	11 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 TIGR00326 (2/2) riboflavin biosynthesis protein RibD PF13641 (2/2) Glycosyltransferase like family 2 PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain PF07690 (2/2) Major Facilitator Superfamily PF07676 (2/2) WD40-like Beta Propeller Repeat PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family PF01872 (2/2) RibD C-terminal domain PF00925 (2/2) GTP cyclohydrolase II PF00400 (2/2) WD domain, G-beta repeat PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_groups_40334	1659.14 +- 53.80	2	0	2	0	0.01 +- 0.01	2	10 PF13622 (2/2) Thioesterase-like superfamily PF12697 (2/2) Alpha/beta hydrolase family PF07690 (2/2) Major Facilitator Superfamily PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00487 (2/2) Fatty acid desaturase PF00326 (2/2) Prolyl oligopeptidase family PF00301 (2/2) Rubredoxin PF00067 (2/2) Cytochrome P450 TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
precursor_groups_1690	929.57 +- 1135.98	28	3	25	26	0.04 +- 0.11	25	8 PF03412 (27/28) Peptidase C39 family PF00664 (27/28) ABC transporter transmembrane region PF00005 (27/28) ABC transporter TIGR03897 (26/28) type 2 lantibiotic biosynthesis protein LanM PF13575 (26/28) Domain of unknown function (DUF4135) PF05147 (26/28) Lanthionine synthetase C-like protein PF14867 (23/28) Lantibiotic alpha PF00296 (19/28) Luciferase-like monooxygenase
precursor_groups_13078	1151.39 +- 1025.31	5	1	1	4	0.05 +- 0.17	4	19 PF03176 (5/5) MMPL family PF00550 (5/5) Phosphopantetheine attachment site PF00202 (5/5) Aminotransferase class-III TIGR03605 (4/5) SagB-type dehydrogenase domain TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase PF08241 (4/5) Methyltransferase domain PF07993 (4/5) Male sterility protein PF03364 (4/5) Polyketide cyclase / dehydrase and lipid transport PF02801 (4/5) Beta-ketoacyl synthase, C-terminal domain PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (4/5) Nitroreductase family PF00698 (4/5) Acyl transferase domain PF00196 (4/5) Bacterial regulatory proteins, luxR family PF00109 (4/5) Beta-ketoacyl synthase, N-terminal domain TIGR03882 (3/5) bacteriocin biosynthesis cyclodehydratase domain PF03473 (3/5) MOSC domain PF01575 (3/5) MaoC like domain PF00675 (3/5) Insulinase (Peptidase family M16)
precursor_groups_69987	895.44 +- 308.77	2	0	2	0	0.02 +- 0.03	2	15 TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF06368 (2/2) Methylaspartate mutase E chain (MutE) PF06339 (2/2) Ectoine synthase PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02310 (2/2) B12 binding domain PF01841 (2/2) Transglutaminase-like superfamily PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_19730	24.99 +- 2.38	2	0	0	0	0.08 +- 0.07	2	3 PF00652 (2/2) Ricin-type beta-trefoil lectin domain PF00457 (2/2) Glycosyl hydrolases family 11 PF00331 (2/2) Glycosyl hydrolase family 10
precursor_groups_7741	338.07 +- 45.25	7	0	1	0	0.09 +- 0.24	7	19 TIGR01902 (7/7) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (7/7) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (7/7) alpha-L-glutamate ligase, RimK family PF18603 (7/7) L-amino acid ligase C-terminal domain 2 PF18130 (7/7) ATP-grasp N-terminal domain PF13535 (7/7) ATP-grasp domain PF08443 (7/7) RimK-like ATP-grasp domain PF07690 (7/7) Major Facilitator Superfamily PF02779 (7/7) Transketolase, pyrimidine binding domain PF01546 (7/7) Peptidase family M20/M25/M40 PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (7/7) Amino acid kinase family PF00456 (7/7) Transketolase, thiamine diphosphate binding domain PF00664 (6/7) ABC transporter transmembrane region PF00005 (6/7) ABC transporter PF13560 (5/7) Helix-turn-helix domain PF10901 (5/7) Protein of unknown function (DUF2690) PF01471 (5/7) Putative peptidoglycan binding domain
precursor_groups_32566	97.43 +- 4.08	3	0	0	0	0.02 +- 0.02	3	2 PF01636 (3/3) Phosphotransferase enzyme family PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_groups_563	355.50 +- 160.50	4	2	2	4	0.03 +- 0.03	2	5 PF05147 (4/4) Lanthionine synthetase C-like protein PF01061 (4/4) ABC-2 type transporter PF00069 (4/4) Protein kinase domain PF00005 (4/4) ABC transporter TIGR01188 (2/4) daunorubicin resistance ABC transporter, ATP-binding protein
precursor_groups_566	491.70 +- 429.24	5	0	0	0	0.02 +- 0.05	5	12 TIGR01509 (5/5) HAD hydrolase, family IA, variant 3 TIGR00879 (5/5) MFS transporter, sugar porter (SP) family PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF13419 (5/5) Haloacid dehalogenase-like hydrolase PF05199 (5/5) GMC oxidoreductase PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold PF00732 (5/5) GMC oxidoreductase PF00682 (5/5) HMGL-like PF00293 (5/5) NUDIX domain PF00083 (5/5) Sugar (and other) transporter PF01761 (4/5) 3-dehydroquinate synthase
precursor_groups_568	387.98 +- 101.27	3	0	3	0	0.06 +- 0.09	3	23 TIGR01746 (3/3) thioester reductase domain TIGR01733 (3/3) amino acid adenylation domain TIGR01525 (3/3) heavy metal translocating P-type ATPase TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (3/3) AMP-binding enzyme C-terminal domain PF10862 (3/3) FcoT-like thioesterase domain PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (3/3) Male sterility protein PF07690 (3/3) Major Facilitator Superfamily PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (3/3) Copper chaperone PCu(A)C PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family PF01497 (3/3) Periplasmic binding protein PF01032 (3/3) FecCD transport family PF00702 (3/3) haloacid dehalogenase-like hydrolase PF00668 (3/3) Condensation domain PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00403 (3/3) Heavy-metal-associated domain PF00122 (3/3) E1-E2 ATPase PF00005 (3/3) ABC transporter PF01965 (2/3) DJ-1/PfpI family
precursor_groups_569	288.11 +- 28.11	2	0	1	1	0.03 +- 0.03	2	11 TIGR03026 (1/2) nucleotide sugar dehydrogenase PF13471 (1/2) Transglutaminase-like superfamily PF04235 (1/2) Protein of unknown function (DUF418) PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF01546 (1/2) Peptidase family M20/M25/M40 PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase PF00733 (1/2) Asparagine synthase PF00583 (1/2) Acetyltransferase (GNAT) family PF00005 (1/2) ABC transporter
precursor_groups_24085	125.56 +- 76.73	4	0	0	0	0.02 +- 0.01	4	4 TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083 PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain PF10977 (4/4) Protein of unknown function (DUF2797) PF07398 (4/4) MDMPI C-terminal domain
precursor_groups_80972	2399.40 +- 696.60	2	0	0	0	0.01 +- 0.00	2	12 PF17914 (2/2) HopA1 effector protein family PF09335 (2/2) SNARE associated Golgi protein PF05193 (2/2) Peptidase M16 inactive domain PF02441 (2/2) Flavoprotein PF01636 (2/2) Phosphotransferase enzyme family PF00891 (2/2) O-methyltransferase domain PF00675 (2/2) Insulinase (Peptidase family M16) PF00664 (2/2) ABC transporter transmembrane region PF00296 (2/2) Luciferase-like monooxygenase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00072 (2/2) Response regulator receiver domain PF00005 (2/2) ABC transporter
precursor_groups_64989	183.91 +- 13.29	2	0	0	0	0.08 +- 0.06	2	18 PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain PF16499 (2/2) Alpha galactosidase A PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region PF07729 (2/2) FCD domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01081 (2/2) KDPG and KHG aldolase PF00583 (2/2) Acetyltransferase (GNAT) family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00067 (2/2) Cytochrome P450 PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
precursor_groups_4804	196.89 +- 6.51	4	0	0	0	0.04 +- 0.15	4	16 TIGR01558 (4/4) putative phage terminase, small subunit, P27 family TIGR01554 (4/4) phage major capsid protein, HK97 family TIGR01543 (4/4) phage prohead protease, HK97 family TIGR01537 (4/4) phage portal protein, HK97 family PF16945 (4/4) Putative lactococcus lactis phage r1t holin PF13229 (4/4) Right handed beta helix region PF10145 (4/4) Phage-related minor tail protein PF05119 (4/4) Phage terminase, small subunit PF05065 (4/4) Phage capsid family PF04860 (4/4) Phage portal protein PF04586 (4/4) Caudovirus prohead serine protease PF03354 (4/4) Phage Terminase PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase PF01476 (4/4) LysM domain PF01464 (4/4) Transglycosylase SLT domain PF01381 (4/4) Helix-turn-helix
precursor_groups_83901	142.22 +- 29.78	2	0	2	0	0.06 +- 0.03	2	8 PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain PF07690 (2/2) Major Facilitator Superfamily PF03466 (2/2) LysR substrate binding domain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00754 (2/2) F5/8 type C domain PF00703 (2/2) Glycosyl hydrolases family 2 PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_30428	332.84 +- 267.53	3	0	0	0	0.06 +- 0.12	3	18 TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain PF09339 (3/3) IclR helix-turn-helix domain PF08501 (3/3) Shikimate dehydrogenase substrate binding domain PF07836 (3/3) DmpG-like communication domain PF07690 (3/3) Major Facilitator Superfamily PF02627 (3/3) Carboxymuconolactone decarboxylase family PF01614 (3/3) Bacterial transcriptional regulator PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family PF01261 (3/3) Xylose isomerase-like TIM barrel PF01220 (3/3) Dehydroquinase class II PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00682 (3/3) HMGL-like PF00083 (3/3) Sugar (and other) transporter TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating) PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain
precursor_groups_27291	186.44 +- 101.19	3	0	0	0	0.02 +- 0.02	3	7 PF16353 (3/3) Domain of unknown function(DUF4981) PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236) PF02929 (3/3) Beta galactosidase small chain PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_69979	64.13 +- 5.87	2	0	0	0	0.06 +- 0.13	2	8 TIGR00753 (2/2) undecaprenyl-diphosphatase UppP PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF12840 (2/2) Helix-turn-helix domain PF07728 (2/2) AAA domain (dynein-related subfamily) PF03088 (2/2) Strictosidine synthase PF02673 (2/2) Bacitracin resistance protein BacA
precursor_groups_9908	131.54 +- 3.07	2	0	0	0	0.09 +- 0.06	2	10 TIGR01382 (2/2) intracellular protease, PfpI family PF13823 (2/2) Alcohol dehydrogenase GroES-associated PF09123 (2/2) Domain of unknown function (DUF1931) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07690 (2/2) Major Facilitator Superfamily PF01965 (2/2) DJ-1/PfpI family PF00248 (2/2) Aldo/keto reductase family PF00107 (2/2) Zinc-binding dehydrogenase PF13515 (1/2) Fusaric acid resistance protein-like PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_groups_75287	971.25 +- 3.75	2	0	0	0	0.01 +- 0.00	2	5 PF13416 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF00962 (2/2) Adenosine/AMP deaminase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_groups_10458	320.07 +- 19.07	2	0	2	0	0.05 +- 0.02	2	18 TIGR00976 (2/2) hydrolase CocE/NonD family protein PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12697 (2/2) Alpha/beta hydrolase family PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF04909 (2/2) Amidohydrolase PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF01144 (2/2) Coenzyme A transferase PF00501 (2/2) AMP-binding enzyme PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00106 (2/2) short chain dehydrogenase PF00005 (2/2) ABC transporter PF01965 (1/2) DJ-1/PfpI family
precursor_groups_86395	777.00 +- 3.00	2	0	0	0	0.01 +- 0.00	2	8 PF14759 (2/2) Reductase C-terminal PF13279 (2/2) Thioesterase-like superfamily PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF01613 (2/2) Flavin reductase like domain PF00775 (2/2) Dioxygenase PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00067 (2/2) Cytochrome P450
precursor_groups_24883	73.19 +- 11.76	2	0	2	0	0.08 +- 0.08	2	14 TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC PF13560 (2/2) Helix-turn-helix domain PF13478 (2/2) XdhC Rossmann domain PF13367 (2/2) PrsW family intramembrane metalloprotease PF13302 (2/2) Acetyltransferase (GNAT) domain PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF02625 (2/2) XdhC and CoxI family PF01799 (2/2) [2Fe-2S] binding domain PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase PF00756 (2/2) Putative esterase PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_10171	369.78 +- 5.91	3	0	0	0	0.07 +- 0.20	3	16 TIGR03177 (3/3) Flp pilus assembly protein CpaB PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB PF15648 (3/3) Restriction endonuclease fold toxin 5 PF13614 (3/3) AAA domain PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase PF07811 (3/3) TadE-like protein PF07730 (3/3) Histidine kinase PF00691 (3/3) OmpA family PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle PF00482 (3/3) Type II secretion system (T2SS), protein F PF00437 (3/3) Type II/IV secretion system protein PF00196 (3/3) Bacterial regulatory proteins, luxR family PF00072 (3/3) Response regulator receiver domain PF00005 (3/3) ABC transporter
precursor_groups_81753	1942.50 +- 7.50	2	0	0	0	0.01 +- 0.00	2	12 TIGR01891 (2/2) amidohydrolase TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR00004 (2/2) reactive intermediate/imine deaminase PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF05299 (2/2) M61 glycyl aminopeptidase PF01979 (2/2) Amidohydrolase family PF01546 (2/2) Peptidase family M20/M25/M40 PF01042 (2/2) Endoribonuclease L-PSP PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00266 (2/2) Aminotransferase class-V PF00005 (2/2) ABC transporter
precursor_groups_15593	303.16 +- 34.84	2	0	0	0	0.06 +- 0.10	2	19 TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily PF14310 (2/2) Fibronectin type III-like domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13529 (2/2) Peptidase_C39 like family PF12697 (2/2) Alpha/beta hydrolase family PF07729 (2/2) FCD domain PF06684 (2/2) Amino acid synthesis PF04545 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF04539 (2/2) Sigma-70 region 3 PF03547 (2/2) Membrane transport protein PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00296 (2/2) Luciferase-like monooxygenase PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_10071	935.22 +- 296.60	9	0	7	9	0.01 +- 0.00	9	6 TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (9/9) SagB-type dehydrogenase domain PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02517 (9/9) CPBP intramembrane metalloprotease PF00881 (9/9) Nitroreductase family PF00296 (9/9) Luciferase-like monooxygenase
precursor_groups_73123	777.00 +- 3.00	2	0	0	0	0.01 +- 0.00	2	7 PF09339 (2/2) IclR helix-turn-helix domain PF07690 (2/2) Major Facilitator Superfamily PF01614 (2/2) Bacterial transcriptional regulator PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00557 (2/2) Metallopeptidase family M24 PF00355 (2/2) Rieske [2Fe-2S] domain PF00171 (2/2) Aldehyde dehydrogenase family
precursor_groups_30634	179.53 +- 21.38	2	0	2	0	0.08 +- 0.15	2	12 PF13641 (2/2) Glycosyltransferase like family 2 PF10823 (2/2) Protein of unknown function (DUF2568) PF09335 (2/2) SNARE associated Golgi protein PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF01810 (2/2) LysE type translocator PF01547 (2/2) Bacterial extracellular solute-binding protein PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00925 (2/2) GTP cyclohydrolase II PF00583 (2/2) Acetyltransferase (GNAT) family PF00400 (2/2) WD domain, G-beta repeat PF00067 (2/2) Cytochrome P450
precursor_groups_1298	137.11 +- 11.03	4	0	4	4	0.03 +- 0.04	4	3 PF13471 (4/4) Transglutaminase-like superfamily PF13302 (4/4) Acetyltransferase (GNAT) domain PF00733 (4/4) Asparagine synthase
precursor_groups_1110	1141.85 +- 566.92	11	6	5	11	0.02 +- 0.02	5	4 PF13471 (11/11) Transglutaminase-like superfamily PF05402 (11/11) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (11/11) Asparagine synthase PF00005 (9/11) ABC transporter
precursor_groups_740	69.46 +- 4.96	2	0	0	0	0.04 +- 0.04	2	8 TIGR03026 (2/2) nucleotide sugar dehydrogenase TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF07690 (2/2) Major Facilitator Superfamily PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase PF12802 (1/2) MarR family
precursor_groups_1501	323.00 +- 111.43	4	0	0	4	0.01 +- 0.00	4	10 TIGR04276 (4/4) FxsC C-terminal domain TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family TIGR04267 (4/4) HEXXH motif domain PF13676 (4/4) TIR domain PF13424 (4/4) Tetratricopeptide repeat PF13374 (4/4) Tetratricopeptide repeat PF04055 (4/4) Radical SAM superfamily PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain PF00931 (4/4) NB-ARC domain TIGR04268 (2/4) FXSXX-COOH protein
precursor_groups_44971	738.11 +- 238.15	3	0	3	0	0.01 +- 0.01	3	13 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF13535 (3/3) ATP-grasp domain PF13394 (3/3) 4Fe-4S single cluster domain PF07690 (3/3) Major Facilitator Superfamily PF06508 (3/3) Queuosine biosynthesis protein QueC PF06368 (3/3) Methylaspartate mutase E chain (MutE) PF02310 (3/3) B12 binding domain PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase PF01227 (3/3) GTP cyclohydrolase I PF00668 (3/3) Condensation domain PF00501 (3/3) AMP-binding enzyme PF00487 (3/3) Fatty acid desaturase
precursor_groups_1057	247.62 +- 143.54	6	0	6	6	0.02 +- 0.03	6	4 TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF05147 (6/6) Lanthionine synthetase C-like protein PF04738 (5/6) Lantibiotic dehydratase, N terminus
precursor_groups_35030	215.00 +- 60.81	3	0	3	0	0.01 +- 0.01	3	3 PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain PF00756 (3/3) Putative esterase PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_groups_18349	782.11 +- 340.79	6	0	0	0	0.01 +- 0.01	6	6 TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain TIGR01420 (6/6) twitching motility protein PF07963 (6/6) Prokaryotic N-terminal methylation motif PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain PF00482 (6/6) Type II secretion system (T2SS), protein F PF00437 (6/6) Type II/IV secretion system protein
precursor_groups_72835	462.83 +- 311.17	2	0	0	0	0.02 +- 0.04	2	6 PF03704 (2/2) Bacterial transcriptional activator domain PF02615 (2/2) Malate/L-lactate dehydrogenase PF01546 (2/2) Peptidase family M20/M25/M40 PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_45577	533.02 +- 31.35	2	0	0	0	0.01 +- 0.00	2	9 TIGR01891 (2/2) amidohydrolase PF14518 (2/2) Iron-containing redox enzyme PF07690 (2/2) Major Facilitator Superfamily PF04204 (2/2) Homoserine O-succinyltransferase PF03704 (2/2) Bacterial transcriptional activator domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme PF00931 (2/2) NB-ARC domain PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_groups_1592	252.97 +- 169.22	9	0	1	0	0.03 +- 0.07	9	5 PF07291 (9/9) Methylamine utilisation protein MauE PF00717 (9/9) Peptidase S24-like PF00005 (9/9) ABC transporter PF10502 (6/9) Signal peptidase, peptidase S26 PF00578 (6/9) AhpC/TSA family
precursor_groups_42755	100.33 +- 20.27	3	0	0	0	0.02 +- 0.02	3	3 PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08924 (3/3) Domain of unknown function (DUF1906) PF00501 (3/3) AMP-binding enzyme
precursor_groups_14774	63.45 +- 1.05	2	0	0	0	0.06 +- 0.06	2	5 PF08220 (2/2) DeoR-like helix-turn-helix domain PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF00455 (2/2) DeoR C terminal sensor domain PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_77109	21.30 +- 0.66	2	0	0	0	0.09 +- 0.13	2	5 TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit PF07077 (2/2) Protein of unknown function (DUF1345) PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport PF01568 (2/2) Molydopterin dinucleotide binding domain PF00384 (2/2) Molybdopterin oxidoreductase
precursor_groups_7824	134.38 +- 26.88	2	0	0	0	0.02 +- 0.01	2	5 PF13515 (2/2) Fusaric acid resistance protein-like PF08386 (2/2) TAP-like protein PF01471 (2/2) Putative peptidoglycan binding domain PF00561 (2/2) alpha/beta hydrolase fold PF00931 (1/2) NB-ARC domain
precursor_groups_5193	34.39 +- 12.89	2	0	2	0	0.09 +- 0.08	2	2 PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family PF01810 (2/2) LysE type translocator
precursor_groups_23	417.58 +- 443.50	3	0	0	0	0.02 +- 0.05	3	3 PF03965 (2/3) Penicillinase repressor PF01435 (2/3) Peptidase family M48 PF00403 (2/3) Heavy-metal-associated domain
precursor_groups_26	338.56 +- 113.59	5	1	3	1	0.09 +- 0.18	4	11 PF03412 (5/5) Peptidase C39 family PF00664 (5/5) ABC transporter transmembrane region PF00005 (5/5) ABC transporter TIGR03797 (4/5) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (4/5) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein PF13437 (4/5) HlyD family secretion protein PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport PF07690 (3/5) Major Facilitator Superfamily PF05013 (3/5) N-formylglutamate amidohydrolase PF03055 (3/5) Retinal pigment epithelial membrane protein PF00440 (3/5) Bacterial regulatory proteins, tetR family
precursor_groups_3158	34.67 +- 0.00	2	0	0	0	0.09 +- 0.12	2	5 TIGR00976 (2/2) hydrolase CocE/NonD family protein PF11361 (2/2) Protein of unknown function (DUF3159) PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF01522 (2/2) Polysaccharide deacetylase
precursor_groups_16507	593.52 +- 220.55	6	0	6	6	0.02 +- 0.04	6	10 TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF08007 (6/6) Cupin superfamily protein PF05147 (6/6) Lanthionine synthetase C-like protein PF04738 (6/6) Lantibiotic dehydratase, N terminus PF00664 (6/6) ABC transporter transmembrane region PF00005 (6/6) ABC transporter TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_3156	174.09 +- 18.88	3	0	0	0	0.07 +- 0.09	3	14 PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5 PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PF16355 (3/3) Domain of unknown function (DUF4982) PF14310 (3/3) Fibronectin type III-like domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain PF07859 (3/3) alpha/beta hydrolase fold PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_5697	196.34 +- 50.80	5	0	0	0	0.08 +- 0.07	5	10 TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family TIGR00976 (5/5) hydrolase CocE/NonD family protein PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family) PF01244 (5/5) Membrane dipeptidase (Peptidase family M19) PF00583 (5/5) Acetyltransferase (GNAT) family PF00528 (5/5) Binding-protein-dependent transport system inner membrane component PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3 PF00005 (5/5) ABC transporter PF00296 (3/5) Luciferase-like monooxygenase
precursor_groups_59389	61.28 +- 3.22	2	0	0	0	0.05 +- 0.03	2	5 PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02386 (2/2) Cation transport protein PF02254 (2/2) TrkA-N domain PF02080 (2/2) TrkA-C domain PF00501 (2/2) AMP-binding enzyme
precursor_groups_345	885.57 +- 176.07	4	0	1	0	0.01 +- 0.01	4	9 TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily PF07690 (4/4) Major Facilitator Superfamily PF03737 (4/4) Aldolase/RraA PF03466 (4/4) LysR substrate binding domain PF01361 (4/4) Tautomerase enzyme PF00994 (4/4) Probable molybdopterin binding domain PF00682 (4/4) HMGL-like PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_68668	38.91 +- 7.53	2	0	0	0	0.08 +- 0.05	2	4 PF13796 (2/2) Putative sensor PF07730 (2/2) Histidine kinase PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase PF00775 (2/2) Dioxygenase
precursor_groups_22163	437.99 +- 138.99	2	0	0	0	0.02 +- 0.10	2	18 TIGR01554 (2/2) phage major capsid protein, HK97 family TIGR01543 (2/2) phage prohead protease, HK97 family TIGR01537 (2/2) phage portal protein, HK97 family PF05065 (2/2) Phage capsid family PF04860 (2/2) Phage portal protein PF04586 (2/2) Caudovirus prohead serine protease PF01844 (2/2) HNH endonuclease PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase TIGR00621 (1/2) single-stranded DNA-binding protein PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily PF12708 (1/2) Pectate lyase superfamily protein PF12307 (1/2) Protein of unknown function (DUF3631) PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal PF05709 (1/2) Phage tail protein PF04851 (1/2) Type III restriction enzyme, res subunit PF00436 (1/2) Single-strand binding protein family PF00271 (1/2) Helicase conserved C-terminal domain
precursor_groups_76120	103.09 +- 21.09	2	0	0	0	0.06 +- 0.08	2	7 TIGR01496 (2/2) dihydropteroate synthase PF08310 (2/2) LGFP repeat PF07995 (2/2) Glucose / Sorbosone dehydrogenase PF03734 (2/2) L,D-transpeptidase catalytic domain PF00809 (2/2) Pterin binding enzyme PF00801 (2/2) PKD domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_groups_35953	121.07 +- 15.52	2	0	0	0	0.03 +- 0.05	2	8 TIGR01297 (2/2) cation diffusion facilitator family transporter PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family PF01695 (2/2) IstB-like ATP binding protein PF01545 (2/2) Cation efflux family PF00665 (2/2) Integrase core domain PF00501 (2/2) AMP-binding enzyme PF00221 (2/2) Aromatic amino acid lyase
precursor_groups_41968	1855.31 +- 282.62	3	0	3	0	0.04 +- 0.15	3	33 TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR01733 (3/3) amino acid adenylation domain TIGR01686 (3/3) FkbH domain TIGR00976 (3/3) hydrolase CocE/NonD family protein PF18563 (3/3) TubC N-terminal docking domain PF16197 (3/3) Ketoacyl-synthetase C-terminal extension PF14765 (3/3) Polyketide synthase dehydratase PF13602 (3/3) Zinc-binding dehydrogenase PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08659 (3/3) KR domain PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF03621 (3/3) MbtH-like protein PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02195 (3/3) ParB-like nuclease domain PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family) PF01266 (3/3) FAD dependent oxidoreductase PF00975 (3/3) Thioesterase domain PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (3/3) Acyl transferase domain PF00668 (3/3) Condensation domain PF00664 (3/3) ABC transporter transmembrane region PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain PF00296 (3/3) Luciferase-like monooxygenase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF00005 (3/3) ABC transporter
precursor_groups_64500	100.71 +- 10.71	2	0	0	0	0.06 +- 0.04	2	3 PF04672 (2/2) S-adenosyl methyltransferase PF01872 (2/2) RibD C-terminal domain PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_16430	409.86 +- 183.82	5	0	5	0	0.02 +- 0.01	5	10 PF13450 (5/5) NAD(P)-binding Rossmann-like domain PF07690 (5/5) Major Facilitator Superfamily PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH) PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family PF00743 (5/5) Flavin-binding monooxygenase-like PF00348 (5/5) Polyprenyl synthetase PF00106 (5/5) short chain dehydrogenase TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_groups_78567	50.96 +- 10.96	2	0	0	0	0.06 +- 0.07	2	4 PF11303 (2/2) Protein of unknown function (DUF3105) PF09335 (2/2) SNARE associated Golgi protein PF02388 (2/2) FemAB family PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
precursor_groups_63631	53.39 +- 20.89	2	0	0	0	0.05 +- 0.04	2	5 PF13602 (2/2) Zinc-binding dehydrogenase PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF00106 (2/2) short chain dehydrogenase PF13564 (1/2) DoxX-like family PF00296 (1/2) Luciferase-like monooxygenase
precursor_groups_12692	968.17 +- 676.53	5	0	5	0	0.07 +- 0.11	5	28 TIGR01746 (5/5) thioester reductase domain TIGR01733 (5/5) amino acid adenylation domain TIGR01525 (5/5) heavy metal translocating P-type ATPase TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (5/5) AMP-binding enzyme C-terminal domain PF10862 (5/5) FcoT-like thioesterase domain PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (5/5) Male sterility protein PF07690 (5/5) Major Facilitator Superfamily PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (5/5) Copper chaperone PCu(A)C PF03929 (5/5) PepSY-associated TM region PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (5/5) DJ-1/PfpI family PF01794 (5/5) Ferric reductase like transmembrane component PF01497 (5/5) Periplasmic binding protein PF01032 (5/5) FecCD transport family PF00702 (5/5) haloacid dehalogenase-like hydrolase PF00668 (5/5) Condensation domain PF00550 (5/5) Phosphopantetheine attachment site PF00501 (5/5) AMP-binding enzyme PF00403 (5/5) Heavy-metal-associated domain PF00122 (5/5) E1-E2 ATPase PF00005 (5/5) ABC transporter TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family PF08281 (4/5) Sigma-70, region 4 PF04542 (4/5) Sigma-70 region 2
precursor_groups_22188	43.48 +- 8.68	3	0	0	0	0.07 +- 0.05	3	9 PF13478 (3/3) XdhC Rossmann domain PF09339 (3/3) IclR helix-turn-helix domain PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase PF02625 (3/3) XdhC and CoxI family PF01799 (3/3) [2Fe-2S] binding domain PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_groups_71012	194.00 +- 64.00	2	0	0	0	0.01 +- 0.01	2	3 PF05901 (2/2) Excalibur calcium-binding domain PF01738 (2/2) Dienelactone hydrolase family PF00293 (2/2) NUDIX domain
precursor_groups_119	75.88 +- 0.00	2	0	0	2	0.07 +- 0.07	2	14 TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme TIGR01828 (2/2) pyruvate, phosphate dikinase TIGR01255 (2/2) formate acetyltransferase PF14325 (2/2) Domain of unknown function (DUF4383) PF13411 (2/2) MerR HTH family regulatory protein PF04055 (2/2) Radical SAM superfamily PF02901 (2/2) Pyruvate formate lyase-like PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain PF02607 (2/2) B12 binding domain PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01228 (2/2) Glycine radical PF00582 (2/2) Universal stress protein family PF00391 (2/2) PEP-utilising enzyme, mobile domain PF00106 (2/2) short chain dehydrogenase
precursor_groups_6108	87.16 +- 4.60	2	0	2	2	0.09 +- 0.18	2	12 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF13649 (2/2) Methyltransferase domain PF05147 (2/2) Lanthionine synthetase C-like protein PF04738 (2/2) Lantibiotic dehydratase, N terminus PF01292 (2/2) Prokaryotic cytochrome b561 PF00296 (2/2) Luciferase-like monooxygenase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00188 (2/2) Cysteine-rich secretory protein family PF00174 (2/2) Oxidoreductase molybdopterin binding domain PF00072 (2/2) Response regulator receiver domain PF00005 (2/2) ABC transporter
precursor_groups_11480	324.25 +- 46.50	3	0	3	0	0.01 +- 0.00	3	7 TIGR01746 (3/3) thioester reductase domain PF13193 (3/3) AMP-binding enzyme C-terminal domain PF07993 (3/3) Male sterility protein PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00300 (3/3) Histidine phosphatase superfamily (branch 1) PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_groups_446	1399.85 +- 1431.38	62	0	8	0	0.02 +- 0.05	62	8 PF17914 (62/62) HopA1 effector protein family PF02441 (61/62) Flavoprotein PF00675 (61/62) Insulinase (Peptidase family M16) PF05193 (59/62) Peptidase M16 inactive domain PF00296 (57/62) Luciferase-like monooxygenase PF00005 (55/62) ABC transporter PF00664 (35/62) ABC transporter transmembrane region PF13649 (33/62) Methyltransferase domain
precursor_groups_14492	164.69 +- 103.36	7	0	0	0	0.05 +- 0.04	7	11 TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating) PF13621 (7/7) Cupin-like domain PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF07836 (7/7) DmpG-like communication domain PF07690 (7/7) Major Facilitator Superfamily PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain PF00682 (7/7) HMGL-like PF00155 (7/7) Aminotransferase class I and II
precursor_groups_39806	205.89 +- 16.36	2	0	0	0	0.06 +- 0.11	2	15 TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (2/2) Domain of unknown function (DUF4380) PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13407 (2/2) Periplasmic binding protein domain PF13378 (2/2) Enolase C-terminal domain-like PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07729 (2/2) FCD domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (2/2) Branched-chain amino acid transport system / permease component PF01081 (2/2) KDPG and KHG aldolase PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00107 (2/2) Zinc-binding dehydrogenase PF00005 (2/2) ABC transporter
precursor_groups_22265	237.00 +- 29.70	3	0	3	0	0.01 +- 0.00	3	9 TIGR01733 (3/3) amino acid adenylation domain PF13193 (3/3) AMP-binding enzyme C-terminal domain PF12680 (3/3) SnoaL-like domain PF08242 (3/3) Methyltransferase domain PF07883 (3/3) Cupin domain PF00975 (3/3) Thioesterase domain PF00668 (3/3) Condensation domain PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme
precursor_groups_16466	273.59 +- 115.10	6	0	0	0	0.03 +- 0.01	6	7 PF07690 (6/6) Major Facilitator Superfamily PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region PF02538 (6/6) Hydantoinase B/oxoprolinase PF01968 (6/6) Hydantoinase/oxoprolinase PF01380 (6/6) SIS domain PF01019 (6/6) Gamma-glutamyltranspeptidase PF00294 (6/6) pfkB family carbohydrate kinase
precursor_groups_16970	592.86 +- 404.30	3	0	0	0	0.05 +- 0.08	3	7 PF13411 (3/3) MerR HTH family regulatory protein PF07739 (3/3) TipAS antibiotic-recognition domain PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain PF01551 (3/3) Peptidase family M23 PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00005 (3/3) ABC transporter PF12679 (2/3) ABC-2 family transporter protein
precursor_groups_41831	445.71 +- 74.29	2	0	2	0	0.01 +- 0.00	2	8 PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02780 (2/2) Transketolase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF00676 (2/2) Dehydrogenase E1 component PF00550 (2/2) Phosphopantetheine attachment site PF00364 (2/2) Biotin-requiring enzyme PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_groups_114	276.73 +- 93.81	4	0	0	0	0.06 +- 0.07	4	16 TIGR01234 (2/4) ribulokinase PF18029 (2/4) Glyoxalase-like domain PF14200 (2/4) Ricin-type beta-trefoil lectin domain-like PF11762 (2/4) L-arabinose isomerase C-terminal domain PF07690 (2/4) Major Facilitator Superfamily PF06964 (2/4) Alpha-L-arabinofuranosidase C-terminal domain PF06772 (2/4) Bacterial low temperature requirement A protein (LtrA) PF02782 (2/4) FGGY family of carbohydrate kinases, C-terminal domain PF02610 (2/4) L-arabinose isomerase PF01547 (2/4) Bacterial extracellular solute-binding protein PF00596 (2/4) Class II Aldolase and Adducin N-terminal domain PF00561 (2/4) alpha/beta hydrolase fold PF00528 (2/4) Binding-protein-dependent transport system inner membrane component PF00370 (2/4) FGGY family of carbohydrate kinases, N-terminal domain PF00296 (2/4) Luciferase-like monooxygenase PF00106 (2/4) short chain dehydrogenase
precursor_groups_77189	362.00 +- 154.00	2	0	2	0	0.01 +- 0.01	2	2 PF08291 (2/2) Peptidase M15 PF01471 (2/2) Putative peptidoglycan binding domain
precursor_groups_47289	358.87 +- 76.47	3	0	3	0	0.03 +- 0.03	3	16 TIGR03396 (3/3) phospholipase C, phosphocholine-specific TIGR01258 (3/3) phosphoglycerate mutase 1 family TIGR01060 (3/3) phosphopyruvate hydratase PF11575 (3/3) FhuF 2Fe-2S C-terminal domain PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF05506 (3/3) Domain of unknown function (DUF756) PF04185 (3/3) Phosphoesterase family PF03965 (3/3) Penicillinase repressor PF03952 (3/3) Enolase, N-terminal domain PF03453 (3/3) MoeA N-terminal region (domain I and II) PF01712 (3/3) Deoxynucleoside kinase PF01435 (3/3) Peptidase family M48 PF00994 (3/3) Probable molybdopterin binding domain PF00300 (3/3) Histidine phosphatase superfamily (branch 1) PF00293 (3/3) NUDIX domain PF00113 (3/3) Enolase, C-terminal TIM barrel domain
precursor_groups_64817	3194.97 +- 210.63	2	0	0	0	0.02 +- 0.01	2	13 TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (2/2) ATP-grasp domain PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (2/2) Prephenate dehydrogenase PF01613 (2/2) Flavin reductase like domain PF01070 (2/2) FMN-dependent dehydrogenase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (2/2) Luciferase-like monooxygenase PF00155 (2/2) Aminotransferase class I and II PF00106 (2/2) short chain dehydrogenase
precursor_groups_23209	51.32 +- 24.99	3	0	0	0	0.05 +- 0.06	3	7 PF13424 (3/3) Tetratricopeptide repeat PF07719 (3/3) Tetratricopeptide repeat PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif PF03413 (3/3) Peptidase propeptide and YPEB domain PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain PF00348 (3/3) Polyprenyl synthetase
precursor_groups_48894	118.75 +- 11.25	2	0	0	0	0.08 +- 0.11	2	7 TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236) PF09084 (2/2) NMT1/THI5 like PF05719 (2/2) Golgi phosphoprotein 3 (GPP34) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter
precursor_groups_27600	144.98 +- 11.02	2	0	0	0	0.09 +- 0.06	2	16 PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region PF07729 (2/2) FCD domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01081 (2/2) KDPG and KHG aldolase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain PF16499 (1/2) Alpha galactosidase A
precursor_groups_15312	166.79 +- 16.68	2	0	2	0	0.05 +- 0.06	2	10 PF17137 (2/2) Domain of unknown function (DUF5110) PF16338 (2/2) Domain of unknown function (DUF4968) PF13520 (2/2) Amino acid permease PF07730 (2/2) Histidine kinase PF03466 (2/2) LysR substrate binding domain PF01055 (2/2) Glycosyl hydrolases family 31 PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00072 (2/2) Response regulator receiver domain PF00069 (2/2) Protein kinase domain
precursor_groups_15314	161.25 +- 96.75	2	0	0	0	0.02 +- 0.03	2	5 TIGR01840 (2/2) esterase, PHB depolymerase family TIGR00666 (2/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase PF14016 (2/2) Protein of unknown function (DUF4232) PF10503 (2/2) Esterase PHB depolymerase PF02113 (2/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_groups_67526	414.64 +- 27.64	2	0	0	0	0.01 +- 0.00	2	3 PF12697 (2/2) Alpha/beta hydrolase family PF07690 (2/2) Major Facilitator Superfamily PF00884 (2/2) Sulfatase
precursor_groups_8062	444.94 +- 356.18	4	0	0	0	0.03 +- 0.04	4	6 PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF03992 (4/4) Antibiotic biosynthesis monooxygenase PF00664 (4/4) ABC transporter transmembrane region PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00248 (4/4) Aldo/keto reductase family PF00005 (4/4) ABC transporter
precursor_groups_22919	502.26 +- 347.48	5	0	5	0	0.05 +- 0.18	5	17 TIGR01509 (5/5) HAD hydrolase, family IA, variant 3 PF13419 (5/5) Haloacid dehalogenase-like hydrolase PF13191 (5/5) AAA ATPase domain PF12710 (5/5) haloacid dehalogenase-like hydrolase PF07690 (5/5) Major Facilitator Superfamily PF04321 (5/5) RmlD substrate binding domain PF01979 (5/5) Amidohydrolase family PF00535 (5/5) Glycosyl transferase family 2 PF00480 (5/5) ROK family PF00459 (5/5) Inositol monophosphatase family PF00294 (5/5) pfkB family carbohydrate kinase PF00202 (5/5) Aminotransferase class-III PF00196 (5/5) Bacterial regulatory proteins, luxR family PF13632 (4/5) Glycosyl transferase family group 2 TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent PF03971 (3/5) Monomeric isocitrate dehydrogenase PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_groups_624	260.57 +- 94.71	2	0	1	0	0.04 +- 0.05	2	10 PF12770 (2/2) CHAT domain PF17866 (1/2) AAA lid domain PF13977 (1/2) BetI-type transcriptional repressor, C-terminal PF13229 (1/2) Right handed beta helix region PF03756 (1/2) A-factor biosynthesis hotdog domain PF01370 (1/2) NAD dependent epimerase/dehydratase family PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00082 (1/2) Subtilase family PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_4272	23.45 +- 0.00	2	0	0	0	0.09 +- 0.07	2	3 PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I PF08241 (2/2) Methyltransferase domain PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_groups_1627	148.42 +- 88.47	10	0	0	10	0.03 +- 0.02	10	3 PF13649 (10/10) Methyltransferase domain PF07690 (10/10) Major Facilitator Superfamily PF04055 (10/10) Radical SAM superfamily
precursor_groups_62305	766.32 +- 13.68	2	0	2	0	0.01 +- 0.00	2	13 TIGR01490 (2/2) HAD hydrolase, family IB PF12710 (2/2) haloacid dehalogenase-like hydrolase PF07690 (2/2) Major Facilitator Superfamily PF03756 (2/2) A-factor biosynthesis hotdog domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01494 (2/2) FAD binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00975 (2/2) Thioesterase domain PF00891 (2/2) O-methyltransferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00248 (2/2) Aldo/keto reductase family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_groups_1150	366.81 +- 92.54	7	0	7	7	0.07 +- 0.08	7	12 TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (7/7) SagB-type dehydrogenase domain TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term PF13191 (7/7) AAA ATPase domain PF04738 (7/7) Lantibiotic dehydratase, N terminus PF03704 (7/7) Bacterial transcriptional activator domain PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (7/7) ABC-2 type transporter PF00881 (7/7) Nitroreductase family PF00486 (7/7) Transcriptional regulatory protein, C terminal PF00005 (7/7) ABC transporter
precursor_groups_79452	372.32 +- 128.18	2	0	0	0	0.03 +- 0.03	2	9 TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence PF13377 (2/2) Periplasmic binding protein-like domain PF12833 (2/2) Helix-turn-helix domain PF02065 (2/2) Melibiase PF01965 (2/2) DJ-1/PfpI family PF01547 (2/2) Bacterial extracellular solute-binding protein PF00652 (2/2) Ricin-type beta-trefoil lectin domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_groups_37210	154.25 +- 11.20	2	0	2	0	0.05 +- 0.16	2	19 TIGR03026 (2/2) nucleotide sugar dehydrogenase TIGR01733 (2/2) amino acid adenylation domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13469 (2/2) Sulfotransferase family PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02615 (2/2) Malate/L-lactate dehydrogenase PF01522 (2/2) Polysaccharide deacetylase PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_groups_19241	148.40 +- 67.91	5	0	0	0	0.02 +- 0.02	5	3 PF08386 (5/5) TAP-like protein PF07228 (5/5) Stage II sporulation protein E (SpoIIE) PF00561 (5/5) alpha/beta hydrolase fold
precursor_groups_23731	734.34 +- 335.62	4	0	4	0	0.06 +- 0.06	4	28 TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family TIGR01746 (4/4) thioester reductase domain TIGR01733 (4/4) amino acid adenylation domain TIGR01525 (4/4) heavy metal translocating P-type ATPase TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (4/4) AMP-binding enzyme C-terminal domain PF10862 (4/4) FcoT-like thioesterase domain PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08281 (4/4) Sigma-70, region 4 PF07993 (4/4) Male sterility protein PF07690 (4/4) Major Facilitator Superfamily PF05118 (4/4) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (4/4) Sigma-70 region 2 PF04314 (4/4) Copper chaperone PCu(A)C PF03929 (4/4) PepSY-associated TM region PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (4/4) DJ-1/PfpI family PF01794 (4/4) Ferric reductase like transmembrane component PF01497 (4/4) Periplasmic binding protein PF01032 (4/4) FecCD transport family PF00702 (4/4) haloacid dehalogenase-like hydrolase PF00668 (4/4) Condensation domain PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00403 (4/4) Heavy-metal-associated domain PF00122 (4/4) E1-E2 ATPase PF00005 (4/4) ABC transporter
precursor_groups_1023	516.00 +- 129.00	2	0	2	2	0.01 +- 0.00	2	5 PF13471 (2/2) Transglutaminase-like superfamily PF00733 (2/2) Asparagine synthase PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00005 (1/2) ABC transporter
precursor_groups_1534	107.29 +- 28.50	2	0	2	2	0.04 +- 0.04	2	10 TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family TIGR00229 (2/2) PAS domain S-box protein PF08448 (2/2) PAS fold PF08447 (2/2) PAS fold PF08386 (2/2) TAP-like protein PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF05147 (2/2) Lanthionine synthetase C-like protein PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00561 (2/2) alpha/beta hydrolase fold PF00069 (2/2) Protein kinase domain
precursor_groups_1431	46.64 +- 3.06	3	0	0	0	0.06 +- 0.07	3	4 PF07730 (3/3) Histidine kinase PF00196 (3/3) Bacterial regulatory proteins, luxR family PF00072 (3/3) Response regulator receiver domain PF13649 (2/3) Methyltransferase domain
precursor_groups_17315	116.33 +- 25.07	6	0	6	6	0.04 +- 0.04	6	4 TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase PF16715 (6/6) Cyclodipeptide synthase PF00881 (6/6) Nitroreductase family PF00089 (6/6) Trypsin
precursor_groups_21458	137.60 +- 68.80	2	0	0	0	0.06 +- 0.05	2	8 PF14864 (2/2) Alkyl sulfatase C-terminal PF14863 (2/2) Alkyl sulfatase dimerisation PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF00753 (2/2) Metallo-beta-lactamase superfamily PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_groups_43861	396.47 +- 171.88	3	0	0	0	0.01 +- 0.02	3	12 TIGR01549 (3/3) HAD hydrolase, family IA, variant 1 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF13535 (3/3) ATP-grasp domain PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF07690 (3/3) Major Facilitator Superfamily PF06245 (3/3) Protein of unknown function (DUF1015) PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
precursor_groups_21455	303.45 +- 53.54	3	0	0	0	0.02 +- 0.01	3	8 PF17286 (3/3) PRMT5 oligomerisation domain PF14518 (3/3) Iron-containing redox enzyme PF13649 (3/3) Methyltransferase domain PF07732 (3/3) Multicopper oxidase PF01323 (3/3) DSBA-like thioredoxin domain PF00701 (3/3) Dihydrodipicolinate synthetase family PF00355 (3/3) Rieske [2Fe-2S] domain PF00155 (3/3) Aminotransferase class I and II
precursor_groups_63	217.46 +- 123.66	7	0	0	0	0.04 +- 0.04	7	No common domains found
precursor_groups_63015	100.79 +- 5.13	2	0	0	0	0.06 +- 0.07	2	14 TIGR01891 (2/2) amidohydrolase PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF13302 (2/2) Acetyltransferase (GNAT) domain PF13091 (2/2) PLD-like domain PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF06267 (2/2) Family of unknown function (DUF1028) PF03466 (2/2) LysR substrate binding domain PF02386 (2/2) Cation transport protein PF02254 (2/2) TrkA-N domain PF02080 (2/2) TrkA-C domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01042 (2/2) Endoribonuclease L-PSP PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00083 (2/2) Sugar (and other) transporter
precursor_groups_61	412.74 +- 203.81	6	0	0	0	0.06 +- 0.19	6	16 PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like PF00691 (6/6) OmpA family PF00482 (6/6) Type II secretion system (T2SS), protein F PF07730 (5/6) Histidine kinase PF00196 (5/6) Bacterial regulatory proteins, luxR family PF00072 (5/6) Response regulator receiver domain TIGR03177 (4/6) Flp pilus assembly protein CpaB PF16976 (4/6) Flp pilus assembly protein RcpC/CpaB PF13614 (4/6) AAA domain PF07811 (4/6) TadE-like protein PF00437 (4/6) Type II/IV secretion system protein PF15648 (3/6) Restriction endonuclease fold toxin 5 PF13231 (3/6) Dolichyl-phosphate-mannose-protein mannosyltransferase PF00528 (3/6) Binding-protein-dependent transport system inner membrane component PF00496 (3/6) Bacterial extracellular solute-binding proteins, family 5 Middle PF00005 (3/6) ABC transporter
precursor_groups_13996	34.94 +- 12.33	2	0	0	0	0.07 +- 0.06	2	2 PF13673 (2/2) Acetyltransferase (GNAT) domain PF01872 (2/2) RibD C-terminal domain
precursor_groups_1870	187.80 +- 17.00	2	0	2	2	0.07 +- 0.08	2	13 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00005 (2/2) ABC transporter TIGR03605 (1/2) SagB-type dehydrogenase domain PF00931 (1/2) NB-ARC domain PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
precursor_groups_18839	142.22 +- 29.78	2	0	2	0	0.06 +- 0.03	2	8 PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain PF07690 (2/2) Major Facilitator Superfamily PF03466 (2/2) LysR substrate binding domain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00754 (2/2) F5/8 type C domain PF00703 (2/2) Glycosyl hydrolases family 2 PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_groups_9334	94.90 +- 28.28	4	0	0	0	0.04 +- 0.02	4	6 PF12697 (4/4) Alpha/beta hydrolase family PF07729 (4/4) FCD domain PF06684 (4/4) Amino acid synthesis PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00296 (4/4) Luciferase-like monooxygenase PF00171 (4/4) Aldehyde dehydrogenase family
precursor_groups_30764	63.45 +- 1.05	2	0	0	0	0.06 +- 0.06	2	5 PF08220 (2/2) DeoR-like helix-turn-helix domain PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF00455 (2/2) DeoR C terminal sensor domain PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_42885	1018.46 +- 114.56	3	0	0	3	0.01 +- 0.00	3	9 PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily PF07690 (3/3) Major Facilitator Superfamily PF05193 (3/3) Peptidase M16 inactive domain PF04055 (3/3) Radical SAM superfamily PF00899 (3/3) ThiF family PF00675 (3/3) Insulinase (Peptidase family M16) PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle PF02310 (2/3) B12 binding domain
precursor_groups_83319	132.91 +- 39.09	2	0	0	0	0.05 +- 0.09	2	7 PF13581 (2/2) Histidine kinase-like ATPase domain PF07690 (2/2) Major Facilitator Superfamily PF07681 (2/2) DoxX PF02515 (2/2) CoA-transferase family III PF01546 (2/2) Peptidase family M20/M25/M40 PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_groups_57593	1632.40 +- 187.60	2	0	2	2	0.01 +- 0.00	2	13 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (2/2) SagB-type dehydrogenase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF13601 (2/2) Winged helix DNA-binding domain PF13191 (2/2) AAA ATPase domain PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_groups_18	1139.50 +- 368.96	3	0	0	2	0.03 +- 0.12	3	5 PF00293 (3/3) NUDIX domain PF00005 (3/3) ABC transporter PF13649 (2/3) Methyltransferase domain PF01636 (2/3) Phosphotransferase enzyme family PF00196 (2/3) Bacterial regulatory proteins, luxR family
precursor_groups_6879	358.32 +- 74.43	10	0	6	0	0.06 +- 0.03	10	18 PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase PF08545 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain PF01144 (10/10) Coenzyme A transferase PF00378 (10/10) Enoyl-CoA hydratase/isomerase PF00196 (10/10) Bacterial regulatory proteins, luxR family PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain PF00106 (10/10) short chain dehydrogenase PF00005 (10/10) ABC transporter TIGR00976 (9/10) hydrolase CocE/NonD family protein PF13193 (9/10) AMP-binding enzyme C-terminal domain PF12679 (9/10) ABC-2 family transporter protein PF08530 (9/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (9/10) X-Pro dipeptidyl-peptidase (S15 family) PF00501 (9/10) AMP-binding enzyme PF04909 (8/10) Amidohydrolase PF12697 (7/10) Alpha/beta hydrolase family
precursor_groups_4652	1090.53 +- 409.47	2	0	0	2	0.04 +- 0.03	2	31 TIGR04364 (2/2) methyltransferase, FxLD system TIGR04363 (2/2) FxLD family lantipeptide TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF13649 (2/2) Methyltransferase domain PF05331 (2/2) Protein of unknown function (DUF742) PF05147 (2/2) Lanthionine synthetase C-like protein PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03259 (2/2) Roadblock/LC7 domain PF03029 (2/2) Conserved hypothetical ATP binding protein PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF01590 (2/2) GAF domain PF01427 (2/2) D-ala-D-ala dipeptidase PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00723 (2/2) Glycosyl hydrolases family 15 PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00293 (2/2) NUDIX domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF13671 (1/2) AAA domain PF13378 (1/2) Enolase C-terminal domain-like PF13242 (1/2) HAD-hyrolase-like PF10103 (1/2) Zincin-like metallopeptidase PF09364 (1/2) XFP N-terminal domain PF09363 (1/2) XFP C-terminal domain PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF03894 (1/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF01300 (1/2) Telomere recombination
precursor_groups_17	441.98 +- 419.76	19	0	7	4	0.03 +- 0.06	19	2 PF13370 (13/19) 4Fe-4S single cluster domain of Ferredoxin I PF00067 (10/19) Cytochrome P450
precursor_groups_1448	73.23 +- 29.66	4	0	0	0	0.05 +- 0.06	4	5 PF14534 (4/4) Domain of unknown function (DUF4440) PF08002 (4/4) Protein of unknown function (DUF1697) PF05922 (4/4) Peptidase inhibitor I9 PF00082 (4/4) Subtilase family PF01323 (2/4) DSBA-like thioredoxin domain
precursor_groups_15	314.31 +- 204.63	20	0	19	0	0.06 +- 0.15	20	15 PF03621 (20/20) MbtH-like protein PF00501 (19/20) AMP-binding enzyme TIGR01733 (18/20) amino acid adenylation domain PF13193 (18/20) AMP-binding enzyme C-terminal domain PF00668 (18/20) Condensation domain PF00550 (18/20) Phosphopantetheine attachment site PF00975 (16/20) Thioesterase domain TIGR01720 (13/20) non-ribosomal peptide synthase domain TIGR01720 TIGR03945 (11/20) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (11/20) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01188 (11/20) daunorubicin resistance ABC transporter, ATP-binding protein PF02423 (11/20) Ornithine cyclodeaminase/mu-crystallin family PF01061 (11/20) ABC-2 type transporter PF00291 (11/20) Pyridoxal-phosphate dependent enzyme PF00005 (11/20) ABC transporter
precursor_groups_3028	24.19 +- 0.00	2	0	0	0	0.08 +- 0.03	2	2 PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF01361 (2/2) Tautomerase enzyme
precursor_groups_9053	226.50 +- 31.50	2	0	0	0	0.01 +- 0.00	2	3 PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA PF00294 (2/2) pfkB family carbohydrate kinase
precursor_groups_7584	511.36 +- 133.14	5	0	2	0	0.04 +- 0.17	5	7 PF17914 (5/5) HopA1 effector protein family PF02441 (5/5) Flavoprotein PF01636 (5/5) Phosphotransferase enzyme family PF00296 (5/5) Luciferase-like monooxygenase PF00005 (4/5) ABC transporter PF02897 (3/5) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (3/5) Prolyl oligopeptidase family
precursor_groups_22780	960.29 +- 332.05	5	0	0	0	0.02 +- 0.01	5	9 PF13649 (5/5) Methyltransferase domain PF12698 (5/5) ABC-2 family transporter protein PF02441 (5/5) Flavoprotein PF00005 (5/5) ABC transporter PF17914 (4/5) HopA1 effector protein family PF01636 (4/5) Phosphotransferase enzyme family PF00664 (4/5) ABC transporter transmembrane region PF13732 (3/5) Domain of unknown function (DUF4162) PF00196 (3/5) Bacterial regulatory proteins, luxR family
precursor_groups_82316	889.37 +- 45.01	2	0	2	0	0.06 +- 0.17	2	27 TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family TIGR01525 (2/2) heavy metal translocating P-type ATPase TIGR00802 (2/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family PF14237 (2/2) GYF domain 2 PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF13421 (2/2) SPFH domain-Band 7 family PF08281 (2/2) Sigma-70, region 4 PF07690 (2/2) Major Facilitator Superfamily PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (2/2) Sigma-70 region 2 PF04314 (2/2) Copper chaperone PCu(A)C PF03824 (2/2) High-affinity nickel-transport protein PF01070 (2/2) FMN-dependent dehydrogenase PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00403 (2/2) Heavy-metal-associated domain PF00122 (2/2) E1-E2 ATPase PF00067 (2/2) Cytochrome P450 TIGR01733 (1/2) amino acid adenylation domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF10862 (1/2) FcoT-like thioesterase domain PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (1/2) Male sterility protein PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme
precursor_groups_68599	291.55 +- 224.45	2	0	0	0	0.03 +- 0.06	2	1 PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_groups_150	243.84 +- 133.73	4	0	1	4	0.07 +- 0.08	4	8 TIGR00976 (4/4) hydrolase CocE/NonD family protein PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family) PF00664 (4/4) ABC transporter transmembrane region PF00005 (4/4) ABC transporter PF01497 (2/4) Periplasmic binding protein PF01032 (2/4) FecCD transport family
precursor_groups_68754	381.16 +- 102.59	2	0	0	0	0.02 +- 0.02	2	4 PF02225 (2/2) PA domain PF01978 (2/2) Sugar-specific transcriptional regulator TrmB PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00082 (2/2) Subtilase family
precursor_groups_12312	593.52 +- 220.55	6	0	6	6	0.02 +- 0.04	6	10 TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF08007 (6/6) Cupin superfamily protein PF05147 (6/6) Lanthionine synthetase C-like protein PF04738 (6/6) Lantibiotic dehydratase, N terminus PF00664 (6/6) ABC transporter transmembrane region PF00005 (6/6) ABC transporter TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_groups_16088	371.41 +- 284.77	6	0	0	0	0.03 +- 0.08	6	16 TIGR01060 (6/6) phosphopyruvate hydratase PF18603 (6/6) L-amino acid ligase C-terminal domain 2 PF18130 (6/6) ATP-grasp N-terminal domain PF16861 (6/6) Carbamoyltransferase C-terminus PF14518 (6/6) Iron-containing redox enzyme PF13535 (6/6) ATP-grasp domain PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family PF07690 (6/6) Major Facilitator Superfamily PF06089 (6/6) L-asparaginase II PF03952 (6/6) Enolase, N-terminal domain PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02543 (6/6) Carbamoyltransferase N-terminus PF00291 (6/6) Pyridoxal-phosphate dependent enzyme PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain PF00113 (6/6) Enolase, C-terminal TIM barrel domain
precursor_groups_21277	1463.93 +- 1117.75	4	0	0	0	0.02 +- 0.01	4	14 PF18603 (4/4) L-amino acid ligase C-terminal domain 2 PF18130 (4/4) ATP-grasp N-terminal domain PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13535 (4/4) ATP-grasp domain PF13378 (4/4) Enolase C-terminal domain-like PF12146 (4/4) Serine aminopeptidase, S33 PF08241 (4/4) Methyltransferase domain PF07690 (4/4) Major Facilitator Superfamily PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH) PF03321 (4/4) GH3 auxin-responsive promoter PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF00694 (4/4) Aconitase C-terminal domain PF00330 (4/4) Aconitase family (aconitate hydratase)
precursor_groups_78723	960.72 +- 458.28	2	0	2	0	0.02 +- 0.02	2	18 PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13191 (2/2) AAA ATPase domain PF08659 (2/2) KR domain PF04820 (2/2) Tryptophan halogenase PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03704 (2/2) Bacterial transcriptional activator domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01613 (2/2) Flavin reductase like domain PF00999 (2/2) Sodium/hydrogen exchanger family PF00975 (2/2) Thioesterase domain PF00931 (2/2) NB-ARC domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00107 (2/2) Zinc-binding dehydrogenase
precursor_groups_2140	108.35 +- 37.40	3	0	1	0	0.09 +- 0.06	3	5 PF13411 (3/3) MerR HTH family regulatory protein PF03476 (3/3) MOSC N-terminal beta barrel domain PF03473 (3/3) MOSC domain PF01551 (3/3) Peptidase family M23 PF00248 (3/3) Aldo/keto reductase family
precursor_groups_2388	699.99 +- 270.33	3	0	3	0	0.07 +- 0.19	3	27 TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family TIGR01525 (3/3) heavy metal translocating P-type ATPase TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family PF14237 (3/3) GYF domain 2 PF13421 (3/3) SPFH domain-Band 7 family PF08281 (3/3) Sigma-70, region 4 PF07690 (3/3) Major Facilitator Superfamily PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (3/3) Sigma-70 region 2 PF04314 (3/3) Copper chaperone PCu(A)C PF03824 (3/3) High-affinity nickel-transport protein PF00702 (3/3) haloacid dehalogenase-like hydrolase PF00403 (3/3) Heavy-metal-associated domain PF00122 (3/3) E1-E2 ATPase TIGR01733 (2/3) amino acid adenylation domain PF13738 (2/3) Pyridine nucleotide-disulphide oxidoreductase PF13193 (2/3) AMP-binding enzyme C-terminal domain PF10862 (2/3) FcoT-like thioesterase domain PF08545 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (2/3) Male sterility protein PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family PF01070 (2/3) FMN-dependent dehydrogenase PF00668 (2/3) Condensation domain PF00550 (2/3) Phosphopantetheine attachment site PF00501 (2/3) AMP-binding enzyme PF00067 (2/3) Cytochrome P450
precursor_groups_23252	68.37 +- 29.84	3	0	0	0	0.07 +- 0.06	3	8 TIGR00350 (3/3) cell envelope-related function transcriptional attenuator common domain PF13399 (3/3) LytR cell envelope-related transcriptional attenuator PF07859 (3/3) alpha/beta hydrolase fold PF03816 (3/3) Cell envelope-related transcriptional attenuator domain PF03807 (3/3) NADP oxidoreductase coenzyme F420-dependent PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase PF00459 (3/3) Inositol monophosphatase family
precursor_groups_36304	571.90 +- 331.10	2	0	0	0	0.02 +- 0.03	2	9 TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083 PF17964 (2/2) Bacterial Ig domain PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF07702 (2/2) UTRA domain PF07398 (2/2) MDMPI C-terminal domain PF03734 (2/2) L,D-transpeptidase catalytic domain PF01381 (2/2) Helix-turn-helix PF00931 (2/2) NB-ARC domain PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_groups_574	693.83 +- 224.35	3	0	2	3	0.05 +- 0.16	3	23 TIGR04364 (3/3) methyltransferase, FxLD system TIGR04363 (3/3) FxLD family lantipeptide TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term PF05147 (3/3) Lanthionine synthetase C-like protein PF04738 (3/3) Lantibiotic dehydratase, N terminus PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF13581 (2/3) Histidine kinase-like ATPase domain PF05331 (2/3) Protein of unknown function (DUF742) PF04851 (2/3) Type III restriction enzyme, res subunit PF04672 (2/3) S-adenosyl methyltransferase PF03457 (2/3) Helicase associated domain PF03259 (2/3) Roadblock/LC7 domain PF03029 (2/3) Conserved hypothetical ATP binding protein PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain PF01636 (2/3) Phosphotransferase enzyme family PF01590 (2/3) GAF domain PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain PF00293 (2/3) NUDIX domain PF00271 (2/3) Helicase conserved C-terminal domain PF00196 (2/3) Bacterial regulatory proteins, luxR family PF00005 (2/3) ABC transporter
precursor_groups_13665	156.96 +- 65.90	2	0	0	0	0.02 +- 0.03	2	4 PF07582 (2/2) AP endonuclease family 2 C terminus PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_groups_32252	379.18 +- 103.46	3	0	3	0	0.08 +- 0.09	3	29 TIGR01746 (3/3) thioester reductase domain TIGR01733 (3/3) amino acid adenylation domain TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR01525 (3/3) heavy metal translocating P-type ATPase TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF13535 (3/3) ATP-grasp domain PF13193 (3/3) AMP-binding enzyme C-terminal domain PF10862 (3/3) FcoT-like thioesterase domain PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region PF07993 (3/3) Male sterility protein PF07690 (3/3) Major Facilitator Superfamily PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (3/3) Copper chaperone PCu(A)C PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (3/3) DJ-1/PfpI family PF01497 (3/3) Periplasmic binding protein PF01032 (3/3) FecCD transport family PF00702 (3/3) haloacid dehalogenase-like hydrolase PF00668 (3/3) Condensation domain PF00550 (3/3) Phosphopantetheine attachment site PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF00501 (3/3) AMP-binding enzyme PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle PF00403 (3/3) Heavy-metal-associated domain PF00122 (3/3) E1-E2 ATPase PF00005 (3/3) ABC transporter
precursor_groups_274	770.06 +- 659.94	2	0	0	0	0.03 +- 0.05	2	15 PF00005 (2/2) ABC transporter PF14903 (1/2) WG containing repeat PF14435 (1/2) SUKH-4 immunity protein PF10042 (1/2) Uncharacterized conserved protein (DUF2278) PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase PF05193 (1/2) Peptidase M16 inactive domain PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain PF01937 (1/2) Protein of unknown function DUF89 PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01061 (1/2) ABC-2 type transporter PF00950 (1/2) ABC 3 transport family PF00675 (1/2) Insulinase (Peptidase family M16) PF00583 (1/2) Acetyltransferase (GNAT) family PF00391 (1/2) PEP-utilising enzyme, mobile domain PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
precursor_groups_64854	246.49 +- 143.51	2	0	2	2	0.04 +- 0.15	2	8 PF11259 (2/2) Protein of unknown function (DUF3060) PF04055 (2/2) Radical SAM superfamily PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF02310 (2/2) B12 binding domain PF01522 (2/2) Polysaccharide deacetylase PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00072 (2/2) Response regulator receiver domain PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_groups_48856	234.00 +- 26.00	2	0	0	0	0.01 +- 0.01	2	6 PF12146 (2/2) Serine aminopeptidase, S33 PF10006 (2/2) Uncharacterized conserved protein (DUF2249) PF09339 (2/2) IclR helix-turn-helix domain PF01979 (2/2) Amidohydrolase family PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family PF00899 (2/2) ThiF family
precursor_groups_279	104.13 +- 69.20	2	0	0	0	0.08 +- 0.16	2	6 TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF13454 (2/2) FAD-NAD(P)-binding PF07920 (2/2) Protein of unknown function (DUF1684) PF02983 (2/2) Alpha-lytic protease prodomain PF00296 (2/2) Luciferase-like monooxygenase PF00089 (2/2) Trypsin
precursor_groups_47384	1855.31 +- 282.62	3	0	3	0	0.04 +- 0.15	3	33 TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR01733 (3/3) amino acid adenylation domain TIGR01686 (3/3) FkbH domain TIGR00976 (3/3) hydrolase CocE/NonD family protein PF18563 (3/3) TubC N-terminal docking domain PF16197 (3/3) Ketoacyl-synthetase C-terminal extension PF14765 (3/3) Polyketide synthase dehydratase PF13602 (3/3) Zinc-binding dehydrogenase PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08659 (3/3) KR domain PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF03621 (3/3) MbtH-like protein PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02195 (3/3) ParB-like nuclease domain PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family) PF01266 (3/3) FAD dependent oxidoreductase PF00975 (3/3) Thioesterase domain PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (3/3) Acyl transferase domain PF00668 (3/3) Condensation domain PF00664 (3/3) ABC transporter transmembrane region PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain PF00296 (3/3) Luciferase-like monooxygenase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF00005 (3/3) ABC transporter
precursor_groups_13328	1552.41 +- 1036.67	5	0	5	0	0.02 +- 0.08	5	11 PF13622 (5/5) Thioesterase-like superfamily PF07690 (5/5) Major Facilitator Superfamily PF00550 (5/5) Phosphopantetheine attachment site PF00501 (5/5) AMP-binding enzyme PF00487 (5/5) Fatty acid desaturase PF00301 (5/5) Rubredoxin PF00067 (5/5) Cytochrome P450 PF12679 (4/5) ABC-2 family transporter protein PF12146 (4/5) Serine aminopeptidase, S33 PF00005 (4/5) ABC transporter PF00392 (3/5) Bacterial regulatory proteins, gntR family
precursor_groups_72506	195.60 +- 94.65	2	0	2	0	0.02 +- 0.02	2	6 PF12697 (2/2) Alpha/beta hydrolase family PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (2/2) Prolyl oligopeptidase family PF00313 (2/2) 'Cold-shock' DNA-binding domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00069 (2/2) Protein kinase domain
precursor_groups_10496	2158.41 +- 761.00	8	0	1	0	0.01 +- 0.01	8	12 PF13560 (8/8) Helix-turn-helix domain PF13393 (8/8) Histidyl-tRNA synthetase PF05193 (8/8) Peptidase M16 inactive domain PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02585 (8/8) GlcNAc-PI de-N-acetylase PF01370 (8/8) NAD dependent epimerase/dehydratase family PF01061 (8/8) ABC-2 type transporter PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00675 (8/8) Insulinase (Peptidase family M16) PF00005 (8/8) ABC transporter PF17874 (7/8) MalT-like TPR region
precursor_groups_1211	920.66 +- 794.45	2	0	0	0	0.02 +- 0.10	2	20 TIGR01554 (2/2) phage major capsid protein, HK97 family TIGR01537 (2/2) phage portal protein, HK97 family PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal PF04860 (2/2) Phage portal protein PF04586 (2/2) Caudovirus prohead serine protease PF01844 (2/2) HNH endonuclease TIGR01543 (1/2) phage prohead protease, HK97 family TIGR00621 (1/2) single-stranded DNA-binding protein PF13481 (1/2) AAA domain PF12728 (1/2) Helix-turn-helix domain PF10935 (1/2) Protein of unknown function (DUF2637) PF10145 (1/2) Phage-related minor tail protein PF05065 (1/2) Phage capsid family PF04851 (1/2) Type III restriction enzyme, res subunit PF01580 (1/2) FtsK/SpoIIIE family PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF01381 (1/2) Helix-turn-helix PF01183 (1/2) Glycosyl hydrolases family 25 PF00436 (1/2) Single-strand binding protein family PF00271 (1/2) Helicase conserved C-terminal domain
precursor_groups_4654	359.93 +- 257.30	9	0	9	0	0.04 +- 0.07	9	10 TIGR01891 (9/9) amidohydrolase TIGR01821 (9/9) 5-aminolevulinic acid synthase PF16884 (9/9) N-terminal domain of oxidoreductase PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07690 (9/9) Major Facilitator Superfamily PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (9/9) Peptidase family M20/M25/M40 PF00155 (9/9) Aminotransferase class I and II PF00107 (9/9) Zinc-binding dehydrogenase
precursor_groups_7635	131.54 +- 3.07	2	0	0	0	0.09 +- 0.06	2	10 TIGR01382 (2/2) intracellular protease, PfpI family PF13823 (2/2) Alcohol dehydrogenase GroES-associated PF09123 (2/2) Domain of unknown function (DUF1931) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07690 (2/2) Major Facilitator Superfamily PF01965 (2/2) DJ-1/PfpI family PF00248 (2/2) Aldo/keto reductase family PF00107 (2/2) Zinc-binding dehydrogenase PF13515 (1/2) Fusaric acid resistance protein-like PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_groups_80912	1334.20 +- 95.80	2	0	0	0	0.02 +- 0.01	2	9 PF17914 (2/2) HopA1 effector protein family PF13649 (2/2) Methyltransferase domain PF12698 (2/2) ABC-2 family transporter protein PF02441 (2/2) Flavoprotein PF01636 (2/2) Phosphotransferase enzyme family PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter PF13732 (1/2) Domain of unknown function (DUF4162) PF00196 (1/2) Bacterial regulatory proteins, luxR family
precursor_groups_84735	45.39 +- 2.39	2	0	2	0	0.04 +- 0.04	2	7 PF12697 (2/2) Alpha/beta hydrolase family PF07063 (2/2) Domain of unknown function (DUF1338) PF01266 (2/2) FAD dependent oxidoreductase PF00171 (2/2) Aldehyde dehydrogenase family PF17874 (1/2) MalT-like TPR region PF13560 (1/2) Helix-turn-helix domain PF13432 (1/2) Tetratricopeptide repeat
precursor_groups_888	174.09 +- 18.88	3	0	0	0	0.07 +- 0.09	3	14 PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5 PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PF16355 (3/3) Domain of unknown function (DUF4982) PF14310 (3/3) Fibronectin type III-like domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain PF07859 (3/3) alpha/beta hydrolase fold PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain PF00703 (3/3) Glycosyl hydrolases family 2
precursor_groups_5445	48.47 +- 11.07	7	0	0	0	0.07 +- 0.10	7	5 PF03450 (7/7) CO dehydrogenase flavoprotein C-terminal domain PF02738 (7/7) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (7/7) [2Fe-2S] binding domain PF01315 (7/7) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (7/7) FAD binding domain in molybdopterin dehydrogenase

Entry name

Average score

Number of operons

Number of MIBiG operons

Number of operons with antismash overlap

Nr of operons with known RiPP domains

Average COG score

Nr of operons passed filter

Common domains

precursor_groups_2166

30.46 +- 5.65

0.07 +- 0.12

PF17853 (2/2) GGDEF-like domain
PF14333 (2/2) Domain of unknown function (DUF4389)
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03492 (2/2) SAM dependent carboxyl methyltransferase

precursor_groups_906

57.96 +- 12.04

0.05 +- 0.10

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF04055 (2/2) Radical SAM superfamily

precursor_groups_239

614.62 +- 470.04

0.07 +- 0.11

TIGR01525 (25/25) heavy metal translocating P-type ATPase
PF04314 (25/25) Copper chaperone PCu(A)C
PF00702 (25/25) haloacid dehalogenase-like hydrolase
PF00403 (25/25) Heavy-metal-associated domain
PF00122 (25/25) E1-E2 ATPase
PF07690 (23/25) Major Facilitator Superfamily
PF05118 (21/25) Aspartyl/Asparaginyl beta-hydroxylase
TIGR01733 (19/25) amino acid adenylation domain
PF13193 (19/25) AMP-binding enzyme C-terminal domain
PF10862 (19/25) FcoT-like thioesterase domain
PF08545 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (19/25) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (19/25) Male sterility protein
PF02668 (19/25) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (19/25) Condensation domain
PF00550 (19/25) Phosphopantetheine attachment site
PF00501 (19/25) AMP-binding enzyme
TIGR01746 (18/25) thioester reductase domain
TIGR00747 (18/25) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF01497 (18/25) Periplasmic binding protein
PF01032 (18/25) FecCD transport family
PF00005 (18/25) ABC transporter
PF01965 (17/25) DJ-1/PfpI family
TIGR02937 (16/25) RNA polymerase sigma factor, sigma-70 family
PF08281 (16/25) Sigma-70, region 4
PF04542 (16/25) Sigma-70 region 2

precursor_groups_33088

240.43 +- 106.11

0.01 +- 0.02

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme

precursor_groups_8175

554.81 +- 177.49

0.02 +- 0.02

TIGR02124 (10/10) hydrogenase expression/formation protein HypE
TIGR01891 (10/10) amidohydrolase
TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (10/10) carbamoyltransferase HypF
PF17788 (10/10) HypF Kae1-like domain
PF13535 (10/10) ATP-grasp domain
PF12680 (10/10) SnoaL-like domain
PF07690 (10/10) Major Facilitator Superfamily
PF07503 (10/10) HypF finger
PF05977 (10/10) Transmembrane secretion effector
PF02769 (10/10) AIR synthase related protein, C-terminal domain
PF01546 (10/10) Peptidase family M20/M25/M40
PF01300 (10/10) Telomere recombination
PF00857 (10/10) Isochorismatase family
PF00708 (10/10) Acylphosphatase
PF00586 (10/10) AIR synthase related protein, N-terminal domain
PF00202 (10/10) Aminotransferase class-III
PF00155 (10/10) Aminotransferase class I and II
PF00583 (9/10) Acetyltransferase (GNAT) family

precursor_groups_8171

414.92 +- 442.96

0.06 +- 0.12

PF13407 (5/5) Periplasmic binding protein domain
PF13377 (5/5) Periplasmic binding protein-like domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF00356 (5/5) Bacterial regulatory proteins, lacI family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00005 (5/5) ABC transporter
PF05025 (4/5) RbsD / FucU transport protein family

precursor_groups_25857

1556.00 +- 516.03

0.01 +- 0.00

PF08386 (4/4) TAP-like protein
PF07702 (4/4) UTRA domain
PF01380 (4/4) SIS domain
PF00561 (4/4) alpha/beta hydrolase fold
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family

precursor_groups_48679

277.22 +- 74.60

0.08 +- 0.08

TIGR01733 (2/2) amino acid adenylation domain
PF18029 (2/2) Glyoxalase-like domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08713 (2/2) DNA alkylation repair enzyme
PF08659 (2/2) KR domain
PF07690 (2/2) Major Facilitator Superfamily
PF07478 (2/2) D-ala D-ala ligase C-terminus
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (2/2) D-ala D-ala ligase N-terminus
PF01494 (2/2) FAD binding domain
PF00975 (2/2) Thioesterase domain
PF00850 (2/2) Histone deacetylase domain
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00698 (2/2) Acyl transferase domain
PF00551 (2/2) Formyl transferase
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00155 (2/2) Aminotransferase class I and II
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_4581

280.13 +- 235.87

0.05 +- 0.16

PF14518 (2/2) Iron-containing redox enzyme
PF12704 (2/2) MacB-like periplasmic core domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF02687 (2/2) FtsX-like permease family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_1662

839.58 +- 460.42

0.02 +- 0.02

TIGR03891 (22/22) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (22/22) Lantibiotic biosynthesis dehydratase C-term
PF05147 (22/22) Lanthionine synthetase C-like protein
PF04738 (22/22) Lantibiotic dehydratase, N terminus
PF00005 (22/22) ABC transporter
TIGR03731 (21/22) lantibiotic, gallidermin/nisin family
PF02052 (18/22) Gallidermin
PF00486 (14/22) Transcriptional regulatory protein, C terminal
PF02518 (12/22) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (12/22) His Kinase A (phospho-acceptor) domain
PF00072 (12/22) Response regulator receiver domain

precursor_groups_41765

760.47 +- 374.44

0.04 +- 0.12

TIGR03567 (3/3) FMN reductase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain
PF14559 (3/3) Tetratricopeptide repeat
PF13535 (3/3) ATP-grasp domain
PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (3/3) Tetratricopeptide repeat
PF13424 (3/3) Tetratricopeptide repeat
PF07690 (3/3) Major Facilitator Superfamily
PF03358 (3/3) NADPH-dependent FMN reductase
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF01613 (3/3) Flavin reductase like domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00294 (3/3) pfkB family carbohydrate kinase
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
PF09334 (2/3) tRNA synthetases class I (M)
PF08281 (2/3) Sigma-70, region 4
PF07883 (2/3) Cupin domain
PF04542 (2/3) Sigma-70 region 2
PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (2/3) MGS-like domain
PF01808 (2/3) AICARFT/IMPCHase bienzyme
PF00709 (2/3) Adenylosuccinate synthetase
PF00355 (2/3) Rieske [2Fe-2S] domain
PF00202 (2/3) Aminotransferase class-III

precursor_groups_31630

43.41 +- 0.41

0.07 +- 0.09

PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00905 (2/2) Penicillin binding protein transpeptidase domain
PF00266 (2/2) Aminotransferase class-V
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_81410

1580.73 +- 635.73

0.02 +- 0.04

PF13649 (2/2) Methyltransferase domain
PF05193 (2/2) Peptidase M16 inactive domain
PF03965 (2/2) Penicillinase repressor
PF01937 (2/2) Protein of unknown function DUF89
PF01475 (2/2) Ferric uptake regulator family
PF01435 (2/2) Peptidase family M48
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter

precursor_groups_60000

182.05 +- 34.62

0.02 +- 0.02

TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF07702 (2/2) UTRA domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_7743

516.00 +- 0.00

0.01 +- 0.00

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (2/2) luciferase family oxidoreductase, group 1
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_20892

133.48 +- 31.64

0.04 +- 0.04

PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF02899 (2/2) Phage integrase, N-terminal SAM-like domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (2/2) NUDIX domain

precursor_groups_23858

419.05 +- 139.95

0.01 +- 0.00

PF17853 (3/3) GGDEF-like domain
PF13556 (3/3) PucR C-terminal helix-turn-helix domain
PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF08592 (3/3) Domain of unknown function (DUF1772)
PF03704 (3/3) Bacterial transcriptional activator domain
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00092 (3/3) von Willebrand factor type A domain
PF01590 (2/3) GAF domain

precursor_groups_4514

1001.47 +- 887.78

0.05 +- 0.18

PF13535 (16/16) ATP-grasp domain
PF13480 (16/16) Acetyltransferase (GNAT) domain
PF13115 (16/16) YtkA-like
PF04389 (16/16) Peptidase family M28
PF02627 (16/16) Carboxymuconolactone decarboxylase family
PF00664 (16/16) ABC transporter transmembrane region
PF00403 (16/16) Heavy-metal-associated domain
PF00155 (16/16) Aminotransferase class I and II
PF00005 (16/16) ABC transporter
TIGR01525 (15/16) heavy metal translocating P-type ATPase
TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (15/16) ATP-grasp domain
PF01676 (15/16) Metalloenzyme superfamily
PF00702 (15/16) haloacid dehalogenase-like hydrolase
PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00122 (15/16) E1-E2 ATPase
PF00117 (15/16) Glutamine amidotransferase class-I
TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase

precursor_groups_19376

140.89 +- 0.00

0.10 +- 0.08

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00931 (2/2) NB-ARC domain
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_44607

275.37 +- 49.63

0.02 +- 0.02

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16884 (2/2) N-terminal domain of oxidoreductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF06441 (2/2) Epoxide hydrolase N terminus
PF00561 (2/2) alpha/beta hydrolase fold
PF00107 (2/2) Zinc-binding dehydrogenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_46039

398.33 +- 178.68

0.02 +- 0.01

PF12697 (3/3) Alpha/beta hydrolase family
PF11723 (3/3) Homotrimeric ring hydroxylase
PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (3/3) Peptidase family M20/M25/M40
PF00561 (3/3) alpha/beta hydrolase fold
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00175 (3/3) Oxidoreductase NAD-binding domain
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_6399

79.05 +- 17.93

0.08 +- 0.03

TIGR02133 (5/5) ribose 5-phosphate isomerase
PF16896 (5/5) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (5/5) Major Facilitator Superfamily
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF02734 (5/5) DAK2 domain
PF02733 (5/5) Dak1 domain
PF02502 (5/5) Ribose/Galactose Isomerase
PF01261 (5/5) Xylose isomerase-like TIM barrel
PF00121 (5/5) Triosephosphate isomerase

precursor_groups_9254

120.00 +- 0.00

0.10 +- 0.25

TIGR00229 (2/2) PAS domain S-box protein
PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796)
PF03098 (2/2) Animal haem peroxidase
PF02585 (2/2) GlcNAc-PI de-N-acetylase
PF01061 (2/2) ABC-2 type transporter
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (2/2) Universal stress protein family
PF00199 (2/2) Catalase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF08448 (1/2) PAS fold
PF00989 (1/2) PAS fold

precursor_groups_62683

3194.97 +- 210.63

0.02 +- 0.01

TIGR01263 (2/2) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF14696 (2/2) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (2/2) ATP-grasp domain
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (2/2) Prephenate dehydrogenase
PF01613 (2/2) Flavin reductase like domain
PF01070 (2/2) FMN-dependent dehydrogenase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (2/2) Luciferase-like monooxygenase
PF00155 (2/2) Aminotransferase class I and II
PF00106 (2/2) short chain dehydrogenase

precursor_groups_19562

118.50 +- 53.50

0.05 +- 0.07

PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin
PF12770 (2/2) CHAT domain
PF07510 (2/2) Protein of unknown function (DUF1524)
PF03235 (2/2) Protein of unknown function DUF262
PF01609 (2/2) Transposase DDE domain
PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF17908 (1/2) APAF-1 helical domain
PF13586 (1/2) Transposase DDE domain
PF04555 (1/2) Restriction endonuclease XhoI
PF01937 (1/2) Protein of unknown function DUF89
PF01636 (1/2) Phosphotransferase enzyme family
PF00931 (1/2) NB-ARC domain
PF00400 (1/2) WD domain, G-beta repeat

precursor_groups_2

284.40 +- 250.53

0.05 +- 0.12

PF04149 (5/6) Domain of unknown function (DUF397)
TIGR01762 (4/6) chlorinating enzyme
TIGR01733 (4/6) amino acid adenylation domain
TIGR01509 (4/6) HAD hydrolase, family IA, variant 3
TIGR01444 (4/6) methyltransferase, FkbM family
TIGR00843 (4/6) benzoate transporter
PF16990 (4/6) Carbohydrate binding module (family 35)
PF13560 (4/6) Helix-turn-helix domain
PF13535 (4/6) ATP-grasp domain
PF13454 (4/6) FAD-NAD(P)-binding
PF13419 (4/6) Haloacid dehalogenase-like hydrolase
PF13193 (4/6) AMP-binding enzyme C-terminal domain
PF07691 (4/6) PA14 domain
PF06439 (4/6) Domain of Unknown Function (DUF1080)
PF05721 (4/6) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/6) Methyltransferase FkbM domain
PF03594 (4/6) Benzoate membrane transport protein
PF02771 (4/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/6) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/6) Fructose-bisphosphate aldolase class-II
PF00975 (4/6) Thioesterase domain
PF00892 (4/6) EamA-like transporter family
PF00550 (4/6) Phosphopantetheine attachment site
PF00501 (4/6) AMP-binding enzyme
PF00441 (4/6) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_1

922.65 +- 1480.94

0.03 +- 0.05

PF04149 (16/16) Domain of unknown function (DUF397)
PF13560 (8/16) Helix-turn-helix domain

precursor_groups_6306

257.74 +- 131.52

0.02 +- 0.10

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13560 (1/2) Helix-turn-helix domain
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF01580 (1/2) FtsK/SpoIIIE family
PF00436 (1/2) Single-strand binding protein family

precursor_groups_4

121.60 +- 155.04

0.05 +- 0.09

TIGR01509 (3/4) HAD hydrolase, family IA, variant 3
PF13419 (3/4) Haloacid dehalogenase-like hydrolase
PF08386 (3/4) TAP-like protein
PF04149 (3/4) Domain of unknown function (DUF397)
PF02388 (3/4) FemAB family
PF00561 (3/4) alpha/beta hydrolase fold

precursor_groups_353

456.93 +- 108.77

0.03 +- 0.03

TIGR03892 (3/3) thiazolylpeptide-type bacteriocin precursor
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF00501 (3/3) AMP-binding enzyme
PF01959 (2/3) 3-dehydroquinate synthase II
PF01791 (2/3) DeoC/LacD family aldolase
PF01494 (2/3) FAD binding domain

precursor_groups_11212

795.64 +- 536.08

0.03 +- 0.08

TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (8/8) SagB-type dehydrogenase domain
TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (8/8) Domain of unknown function (DUF4135)
PF03412 (8/8) Peptidase C39 family
PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (8/8) Nitroreductase family
PF00664 (8/8) ABC transporter transmembrane region
PF00067 (8/8) Cytochrome P450
PF00005 (8/8) ABC transporter
PF00364 (6/8) Biotin-requiring enzyme
PF05147 (4/8) Lanthionine synthetase C-like protein

precursor_groups_31252

1255.97 +- 999.97

0.03 +- 0.06

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF13187 (4/4) 4Fe-4S dicluster domain
PF08659 (4/4) KR domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (4/4) Major Facilitator Superfamily
PF07228 (4/4) Stage II sporulation protein E (SpoIIE)
PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF01070 (4/4) FMN-dependent dehydrogenase
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF13459 (3/4) 4Fe-4S single cluster domain
PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF09335 (3/4) SNARE associated Golgi protein
PF07730 (3/4) Histidine kinase
PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00196 (3/4) Bacterial regulatory proteins, luxR family
PF00072 (3/4) Response regulator receiver domain

precursor_groups_3707

1270.23 +- 755.78

0.02 +- 0.03

TIGR03897 (18/18) type 2 lantibiotic biosynthesis protein LanM
PF13575 (18/18) Domain of unknown function (DUF4135)
PF05147 (18/18) Lanthionine synthetase C-like protein
PF03412 (18/18) Peptidase C39 family
PF00664 (18/18) ABC transporter transmembrane region
PF00005 (18/18) ABC transporter
PF14867 (16/18) Lantibiotic alpha
PF12730 (15/18) ABC-2 family transporter protein

precursor_groups_46517

138.46 +- 43.67

0.03 +- 0.02

PF17291 (3/3) N-terminal domain of M60-like peptidases
PF13402 (3/3) Peptidase M60, enhancin and enhancin-like
PF13377 (3/3) Periplasmic binding protein-like domain
PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (3/3) Bacterial regulatory proteins, lacI family

precursor_groups_41235

63.35 +- 11.31

0.05 +- 0.03

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family

precursor_groups_17587

116.33 +- 25.07

0.04 +- 0.04

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

precursor_groups_121

1363.95 +- 1630.95

0.04 +- 0.08

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF03704 (4/4) Bacterial transcriptional activator domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (4/4) ABC-2 type transporter
PF00881 (4/4) Nitroreductase family
PF00486 (4/4) Transcriptional regulatory protein, C terminal
PF00005 (4/4) ABC transporter
TIGR03892 (3/4) thiazolylpeptide-type bacteriocin precursor
TIGR01891 (3/4) amidohydrolase
PF01546 (3/4) Peptidase family M20/M25/M40
PF00296 (2/4) Luciferase-like monooxygenase

precursor_groups_34009

377.27 +- 142.73

0.02 +- 0.01

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF07202 (2/2) T-complex protein 10 C-terminus
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family
PF00652 (2/2) Ricin-type beta-trefoil lectin domain

precursor_groups_21556

832.00 +- 254.75

0.01 +- 0.00

PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02441 (5/5) Flavoprotein

precursor_groups_18390

864.29 +- 155.78

0.01 +- 0.02

TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF08241 (3/3) Methyltransferase domain
PF07690 (3/3) Major Facilitator Superfamily
PF04055 (3/3) Radical SAM superfamily
PF01980 (3/3) tRNA-methyltransferase O
PF01494 (3/3) FAD binding domain
PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family

precursor_groups_44042

47.53 +- 2.00

0.06 +- 0.06

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I

precursor_groups_71616

195.00 +- 0.00

0.02 +- 0.00

TIGR00229 (2/2) PAS domain S-box protein
PF17148 (2/2) Domain of unknown function (DUF5117)
PF16313 (2/2) Met-zincin
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13426 (2/2) PAS domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07702 (2/2) UTRA domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_61212

101.28 +- 23.28

0.05 +- 0.10

PF13581 (2/2) Histidine kinase-like ATPase domain
PF13191 (2/2) AAA ATPase domain
PF09346 (2/2) SMI1 / KNR4 family (SUKH-1)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00561 (2/2) alpha/beta hydrolase fold
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF04978 (1/2) Protein of unknown function (DUF664)

precursor_groups_3209

61.10 +- 12.21

0.05 +- 0.02

PF01292 (3/3) Prokaryotic cytochrome b561
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF07519 (2/3) Tannase and feruloyl esterase

precursor_groups_55307

481.90 +- 168.10

0.02 +- 0.02

PF13377 (2/2) Periplasmic binding protein-like domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF00266 (2/2) Aminotransferase class-V

precursor_groups_83750

705.83 +- 204.17

0.01 +- 0.01

PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (2/2) MftR C-terminal domain
PF13460 (2/2) NAD(P)H-binding
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF01418 (2/2) Helix-turn-helix domain, rpiR family
PF01380 (2/2) SIS domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family

precursor_groups_41801

344.00 +- 86.00

0.01 +- 0.01

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR01643 (2/2) YD repeat (two copies)
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF13424 (2/2) Tetratricopeptide repeat
PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic
PF05593 (2/2) RHS Repeat
PF00156 (2/2) Phosphoribosyl transferase domain

precursor_groups_36866

332.14 +- 118.84

0.02 +- 0.01

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family

precursor_groups_545

287.08 +- 232.92

0.04 +- 0.10

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07730 (2/2) Histidine kinase
PF06722 (2/2) Protein of unknown function (DUF1205)
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain

precursor_groups_542

156.12 +- 66.54

0.07 +- 0.06

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF17900 (1/2) Peptidase M1 N-terminal domain
PF03814 (1/2) Potassium-transporting ATPase A subunit
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01433 (1/2) Peptidase family M1 domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00331 (1/2) Glycosyl hydrolase family 10
PF00293 (1/2) NUDIX domain

precursor_groups_11589

780.00 +- 260.00

0.01 +- 0.00

PF07690 (6/6) Major Facilitator Superfamily
PF04055 (6/6) Radical SAM superfamily
PF02441 (6/6) Flavoprotein
PF02310 (3/6) B12 binding domain

precursor_groups_11233

4608.81 +- 2021.19

0.02 +- 0.03

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF11468 (2/2) Aromatic prenyltransferase Orf2
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01527 (2/2) Transposase
PF01061 (2/2) ABC-2 type transporter
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13847 (1/2) Methyltransferase domain
PF13589 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF13489 (1/2) Methyltransferase domain
PF00183 (1/2) Hsp90 protein
PF00069 (1/2) Protein kinase domain

precursor_groups_104

219.64 +- 53.64

0.04 +- 0.06

PF13545 (9/11) Crp-like helix-turn-helix domain
PF07228 (9/11) Stage II sporulation protein E (SpoIIE)
PF00027 (9/11) Cyclic nucleotide-binding domain

precursor_groups_4868

229.23 +- 30.77

0.01 +- 0.01

PF03412 (3/3) Peptidase C39 family
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF00535 (2/3) Glycosyl transferase family 2

precursor_groups_17449

216.17 +- 107.83

0.04 +- 0.05

TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family
TIGR01979 (2/2) cysteine desulfurase, SufS family
PF16868 (2/2) NMT1-like family
PF05977 (2/2) Transmembrane secretion effector
PF04185 (2/2) Phosphoesterase family
PF00266 (2/2) Aminotransferase class-V
PF00027 (2/2) Cyclic nucleotide-binding domain
TIGR01167 (1/2) LPXTG cell wall anchor domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)

precursor_groups_68315

1554.00 +- 6.00

0.01 +- 0.00

PF08007 (2/2) Cupin superfamily protein
PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter

precursor_groups_70666

85.00 +- 45.00

0.03 +- 0.03

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_groups_23434

338.00 +- 182.00

0.02 +- 0.06

PF07291 (2/2) Methylamine utilisation protein MauE
PF00717 (2/2) Peptidase S24-like
PF00005 (2/2) ABC transporter
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF10502 (1/2) Signal peptidase, peptidase S26
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01494 (1/2) FAD binding domain
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00578 (1/2) AhpC/TSA family
PF00440 (1/2) Bacterial regulatory proteins, tetR family

precursor_groups_11906

183.10 +- 82.91

0.01 +- 0.01

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase

precursor_groups_78352

259.00 +- 1.00

0.01 +- 0.00

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_20733

765.63 +- 127.45

0.01 +- 0.01

PF11953 (2/2) Domain of unknown function (DUF3470)
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02597 (2/2) ThiS family
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (2/2) 4Fe-4S binding domain
PF00550 (1/2) Phosphopantetheine attachment site

precursor_groups_77605

230.67 +- 116.00

0.02 +- 0.03

PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_35663

122.11 +- 15.00

0.08 +- 0.21

PF13191 (3/3) AAA ATPase domain
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF02254 (3/3) TrkA-N domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF00717 (3/3) Peptidase S24-like
PF00664 (3/3) ABC transporter transmembrane region
PF00005 (3/3) ABC transporter
PF13181 (2/3) Tetratricopeptide repeat

precursor_groups_15437

282.51 +- 110.62

0.01 +- 0.01

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain
PF03551 (6/6) Transcriptional regulator PadR-like family
PF01478 (6/6) Type IV leader peptidase family

precursor_groups_2281

800.06 +- 256.65

0.01 +- 0.01

PF17914 (6/6) HopA1 effector protein family
PF05193 (6/6) Peptidase M16 inactive domain
PF01636 (6/6) Phosphotransferase enzyme family
PF00675 (6/6) Insulinase (Peptidase family M16)
PF13649 (5/6) Methyltransferase domain
PF13546 (5/6) DDE superfamily endonuclease
PF02441 (5/6) Flavoprotein
PF00005 (5/6) ABC transporter
TIGR00414 (3/6) serine--tRNA ligase
PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain
PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)

precursor_groups_10508

299.00 +- 23.50

0.05 +- 0.09

TIGR01764 (2/2) DNA binding domain, excisionase family
PF13411 (2/2) MerR HTH family regulatory protein
PF13245 (2/2) AAA domain
PF12728 (2/2) Helix-turn-helix domain
PF12697 (2/2) Alpha/beta hydrolase family
PF12679 (2/2) ABC-2 family transporter protein
PF07739 (2/2) TipAS antibiotic-recognition domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF01551 (2/2) Peptidase family M23
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00005 (2/2) ABC transporter
PF13673 (1/2) Acetyltransferase (GNAT) domain

precursor_groups_5419

953.88 +- 214.88

0.01 +- 0.01

TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (4/4) Iron-sulfur cluster-binding domain
PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (4/4) Radical SAM superfamily
PF01061 (4/4) ABC-2 type transporter
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter

precursor_groups_23648

167.66 +- 10.77

0.06 +- 0.03

TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF01593 (2/2) Flavin containing amine oxidoreductase
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter

precursor_groups_765

190.01 +- 103.85

0.04 +- 0.06

TIGR03975 (17/17) ribosomal peptide maturation radical SAM protein 1
PF07690 (17/17) Major Facilitator Superfamily
PF02310 (17/17) B12 binding domain
PF00326 (17/17) Prolyl oligopeptidase family
PF04055 (16/17) Radical SAM superfamily

precursor_groups_75057

2220.43 +- 119.57

0.01 +- 0.00

PF14081 (2/2) Domain of unknown function (DUF4262)
PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (2/2) SAF domain
PF07811 (2/2) TadE-like protein
PF01476 (2/2) LysM domain
PF01381 (2/2) Helix-turn-helix
PF00482 (2/2) Type II secretion system (T2SS), protein F
PF00437 (2/2) Type II/IV secretion system protein

precursor_groups_1137

203.30 +- 256.64

0.04 +- 0.05

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase

precursor_groups_45170

1548.00 +- 0.00

0.01 +- 0.00

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF13242 (2/2) HAD-hyrolase-like
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (2/2) Radical SAM superfamily
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02811 (2/2) PHP domain
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00535 (2/2) Glycosyl transferase family 2
PF00501 (2/2) AMP-binding enzyme
PF00202 (2/2) Aminotransferase class-III

precursor_groups_40558

609.27 +- 165.86

0.01 +- 0.00

TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase
PF14518 (3/3) Iron-containing redox enzyme
PF13378 (3/3) Enolase C-terminal domain-like
PF07690 (3/3) Major Facilitator Superfamily
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01063 (3/3) Amino-transferase class IV
PF00682 (3/3) HMGL-like
TIGR00035 (2/3) aspartate racemase
PF01177 (2/3) Asp/Glu/Hydantoin racemase

precursor_groups_24923

595.57 +- 149.62

0.01 +- 0.00

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (4/4) Dimerisation domain
PF14015 (4/4) Protein of unknown function (DUF4231)
PF13692 (4/4) Glycosyl transferases group 1
PF13676 (4/4) TIR domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (4/4) Maltose acetyltransferase
PF11941 (4/4) Domain of unknown function (DUF3459)
PF07728 (4/4) AAA domain (dynein-related subfamily)
PF05729 (4/4) NACHT domain
PF01636 (4/4) Phosphotransferase enzyme family
PF00891 (4/4) O-methyltransferase domain
PF00202 (4/4) Aminotransferase class-III
PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)

precursor_groups_20597

400.13 +- 221.16

0.05 +- 0.17

TIGR02100 (3/3) glycogen debranching enzyme GlgX
TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme
TIGR00377 (3/3) anti-anti-sigma factor
PF18085 (3/3) Maltokinase N-terminal cap domain
PF17124 (3/3) ThiJ/PfpI family-like
PF13614 (3/3) AAA domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13546 (3/3) DDE superfamily endonuclease
PF13466 (3/3) STAS domain
PF13460 (3/3) NAD(P)H-binding
PF13380 (3/3) CoA binding domain
PF11896 (3/3) Domain of unknown function (DUF3416)
PF07690 (3/3) Major Facilitator Superfamily
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
PF07110 (3/3) EthD domain
PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (3/3) Alpha amylase, C-terminal all-beta domain
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (3/3) DJ-1/PfpI family
PF01740 (3/3) STAS domain
PF00483 (3/3) Nucleotidyl transferase
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
PF00132 (3/3) Bacterial transferase hexapeptide (six repeats)
PF00128 (3/3) Alpha amylase, catalytic domain

precursor_groups_22333

154.80 +- 0.00

0.02 +- 0.01

TIGR01549 (2/2) HAD hydrolase, family IA, variant 1
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF09130 (2/2) Domain of unknown function (DUF1932)
PF02384 (2/2) N-6 DNA Methylase
PF01341 (2/2) Glycosyl hydrolases family 6

precursor_groups_12158

2061.33 +- 765.80

0.01 +- 0.01

PF17874 (7/7) MalT-like TPR region
PF13560 (7/7) Helix-turn-helix domain
PF13393 (7/7) Histidyl-tRNA synthetase
PF05193 (7/7) Peptidase M16 inactive domain
PF03721 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (7/7) GlcNAc-PI de-N-acetylase
PF01370 (7/7) NAD dependent epimerase/dehydratase family
PF01061 (7/7) ABC-2 type transporter
PF00984 (7/7) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (7/7) Insulinase (Peptidase family M16)
PF00005 (7/7) ABC transporter

precursor_groups_61591

306.43 +- 83.57

0.01 +- 0.00

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00155 (2/2) Aminotransferase class I and II

precursor_groups_6342

216.00 +- 44.00

0.03 +- 0.04

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_1450

759.98 +- 690.09

0.06 +- 0.20

PF06114 (3/3) IrrE N-terminal-like domain
PF05147 (3/3) Lanthionine synthetase C-like protein
PF02687 (3/3) FtsX-like permease family
PF00082 (3/3) Subtilase family
PF00069 (3/3) Protein kinase domain
PF00005 (3/3) ABC transporter

precursor_groups_14823

174.93 +- 114.89

0.03 +- 0.05

PF13577 (6/6) SnoaL-like domain
PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase
PF12697 (6/6) Alpha/beta hydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF04444 (6/6) Catechol dioxygenase N terminus
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00775 (6/6) Dioxygenase
PF00465 (6/6) Iron-containing alcohol dehydrogenase

precursor_groups_1355

178.94 +- 79.06

0.04 +- 0.07

PF00067 (2/2) Cytochrome P450
PF14534 (1/2) Domain of unknown function (DUF4440)
PF08002 (1/2) Protein of unknown function (DUF1697)
PF05922 (1/2) Peptidase inhibitor I9
PF00082 (1/2) Subtilase family

precursor_groups_45774

344.00 +- 86.00

0.01 +- 0.01

precursor_groups_73507

1554.00 +- 6.00

0.01 +- 0.00

precursor_groups_9108

117.34 +- 48.52

0.03 +- 0.04

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family

precursor_groups_64153

258.09 +- 86.03

0.03 +- 0.05

PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13581 (2/2) Histidine kinase-like ATPase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (2/2) WYL domain
PF08279 (2/2) HTH domain
PF04055 (2/2) Radical SAM superfamily
PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02310 (2/2) B12 binding domain
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein
PF00293 (2/2) NUDIX domain
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00005 (2/2) ABC transporter

precursor_groups_84823

3194.97 +- 210.63

0.02 +- 0.01

precursor_groups_78012

710.45 +- 47.26

0.03 +- 0.03

precursor_groups_6043

131.54 +- 3.07

0.09 +- 0.06

TIGR01382 (2/2) intracellular protease, PfpI family
PF13823 (2/2) Alcohol dehydrogenase GroES-associated
PF09123 (2/2) Domain of unknown function (DUF1931)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF01965 (2/2) DJ-1/PfpI family
PF00248 (2/2) Aldo/keto reductase family
PF00107 (2/2) Zinc-binding dehydrogenase
PF13515 (1/2) Fusaric acid resistance protein-like
PF12805 (1/2) FUSC-like inner membrane protein yccS

precursor_groups_70686

650.00 +- 0.00

0.02 +- 0.00

TIGR01484 (2/2) HAD hydrolase, family IIB
PF08282 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF01259 (2/2) SAICAR synthetase
PF00326 (2/2) Prolyl oligopeptidase family
PF00106 (2/2) short chain dehydrogenase

precursor_groups_71289

155.40 +- 85.40

0.04 +- 0.04

TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00293 (2/2) NUDIX domain
PF00221 (2/2) Aromatic amino acid lyase
PF00082 (2/2) Subtilase family

precursor_groups_1957

91.17 +- 58.33

0.03 +- 0.02

PF12833 (18/18) Helix-turn-helix domain
PF02311 (18/18) AraC-like ligand binding domain
PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)

precursor_groups_165

32.06 +- 9.93

0.07 +- 0.05

PF17074 (8/8) Darcynin, domain of unknown function
PF08021 (8/8) Siderophore-interacting FAD-binding domain
PF04954 (8/8) Siderophore-interacting protein
PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_5606

65.80 +- 23.86

0.05 +- 0.06

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (1/2) Glycosyl hydrolase family 92

precursor_groups_79714

2072.00 +- 8.00

0.01 +- 0.00

PF08386 (2/2) TAP-like protein
PF07702 (2/2) UTRA domain
PF01380 (2/2) SIS domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_17666

49.71 +- 15.29

0.07 +- 0.08

PF14518 (2/2) Iron-containing redox enzyme
PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (2/2) Subtilase family

precursor_groups_1821

358.75 +- 32.16

0.01 +- 0.01

TIGR01558 (2/2) putative phage terminase, small subunit, P27 family
TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (2/2) Phage-related minor tail protein
PF05119 (2/2) Phage terminase, small subunit
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04586 (2/2) Caudovirus prohead serine protease
PF04542 (2/2) Sigma-70 region 2
PF03354 (2/2) Phage Terminase
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (2/2) Collagen triple helix repeat (20 copies)
PF01381 (2/2) Helix-turn-helix
PF00271 (2/2) Helicase conserved C-terminal domain

precursor_groups_68266

388.00 +- 128.00

0.01 +- 0.00

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07729 (2/2) FCD domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00561 (2/2) alpha/beta hydrolase fold
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_463

130.00 +- 70.00

0.04 +- 0.03

PF12833 (2/2) Helix-turn-helix domain
PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/2) mttA/Hcf106 family
PF00743 (2/2) Flavin-binding monooxygenase-like
PF00171 (2/2) Aldehyde dehydrogenase family
PF00106 (2/2) short chain dehydrogenase

precursor_groups_462

509.83 +- 454.74

0.05 +- 0.15

TIGR01850 (34/34) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (34/34) RimK-like ATP-grasp domain
PF02779 (34/34) Transketolase, pyrimidine binding domain
PF01118 (34/34) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (34/34) Transketolase, thiamine diphosphate binding domain
TIGR00768 (30/34) alpha-L-glutamate ligase, RimK family
TIGR01902 (23/34) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (23/34) Peptidase family M20/M25/M40
PF01041 (23/34) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (23/34) Amino acid kinase family
PF07690 (18/34) Major Facilitator Superfamily
PF18603 (17/34) L-amino acid ligase C-terminal domain 2
PF18130 (17/34) ATP-grasp N-terminal domain
PF13535 (17/34) ATP-grasp domain
PF02780 (17/34) Transketolase, C-terminal domain

precursor_groups_9061

189.23 +- 42.98

0.02 +- 0.01

PF13191 (2/2) AAA ATPase domain
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_500

726.73 +- 607.66

0.08 +- 0.19

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/2) amidohydrolase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (1/2) Histidine kinase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03412 (1/2) Peptidase C39 family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (1/2) Peptidase family M20/M25/M40
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00877 (1/2) NlpC/P60 family
PF00664 (1/2) ABC transporter transmembrane region
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter

precursor_groups_265

135.53 +- 39.47

0.06 +- 0.09

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF13411 (2/2) MerR HTH family regulatory protein
PF08281 (2/2) Sigma-70, region 4
PF07739 (2/2) TipAS antibiotic-recognition domain
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase

precursor_groups_44077

763.96 +- 609.16

0.05 +- 0.14

TIGR03696 (2/2) RHS repeat-associated core domain
TIGR03494 (2/2) salicylate synthase
TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family
TIGR01733 (2/2) amino acid adenylation domain
TIGR01643 (2/2) YD repeat (two copies)
TIGR01443 (2/2) intein C-terminal splicing region
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (2/2) Pretoxin HINT domain
PF05593 (2/2) RHS Repeat
PF03704 (2/2) Bacterial transcriptional activator domain
PF02361 (2/2) Cobalt transport protein
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00425 (2/2) chorismate binding enzyme
PF00005 (2/2) ABC transporter
TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF13537 (1/2) Glutamine amidotransferase domain
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region

precursor_groups_41937

915.56 +- 502.62

0.01 +- 0.01

PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07722 (2/2) Peptidase C26
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (2/2) Aminotransferase class-III
PF00171 (2/2) Aldehyde dehydrogenase family
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_22977

3011.04 +- 331.81

0.01 +- 0.01

PF13649 (2/2) Methyltransferase domain
PF12730 (2/2) ABC-2 family transporter protein
PF05147 (2/2) Lanthionine synthetase C-like protein
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF00296 (2/2) Luciferase-like monooxygenase
PF00202 (2/2) Aminotransferase class-III
PF00069 (2/2) Protein kinase domain
PF00005 (2/2) ABC transporter

precursor_groups_4638

1058.04 +- 888.53

0.05 +- 0.18

TIGR01307 (15/15) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13535 (15/15) ATP-grasp domain
PF13480 (15/15) Acetyltransferase (GNAT) domain
PF13115 (15/15) YtkA-like
PF04389 (15/15) Peptidase family M28
PF02627 (15/15) Carboxymuconolactone decarboxylase family
PF01676 (15/15) Metalloenzyme superfamily
PF00664 (15/15) ABC transporter transmembrane region
PF00403 (15/15) Heavy-metal-associated domain
PF00275 (15/15) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (15/15) Aminotransferase class I and II
PF00117 (15/15) Glutamine amidotransferase class-I
PF00005 (15/15) ABC transporter
TIGR01525 (14/15) heavy metal translocating P-type ATPase
TIGR01356 (14/15) 3-phosphoshikimate 1-carboxyvinyltransferase
PF13549 (14/15) ATP-grasp domain
PF00702 (14/15) haloacid dehalogenase-like hydrolase
PF00122 (14/15) E1-E2 ATPase

precursor_groups_15205

169.73 +- 174.91

0.05 +- 0.09

TIGR00229 (6/6) PAS domain S-box protein
PF08448 (6/6) PAS fold
PF08220 (6/6) DeoR-like helix-turn-helix domain
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain
PF01590 (6/6) GAF domain
PF00455 (6/6) DeoR C terminal sensor domain
PF00440 (6/6) Bacterial regulatory proteins, tetR family
PF00069 (6/6) Protein kinase domain
PF01494 (3/6) FAD binding domain

precursor_groups_62121

151.58 +- 28.42

0.02 +- 0.02

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme

precursor_groups_62573

376.25 +- 0.00

0.03 +- 0.03

TIGR01656 (2/2) histidinol-phosphate phosphatase domain
TIGR01444 (2/2) methyltransferase, FkbM family
PF16363 (2/2) GDP-mannose 4,6 dehydratase
PF13242 (2/2) HAD-hyrolase-like
PF12804 (2/2) MobA-like NTP transferase domain
PF12146 (2/2) Serine aminopeptidase, S33
PF05050 (2/2) Methyltransferase FkbM domain
PF04055 (2/2) Radical SAM superfamily
PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02709 (2/2) N-terminal domain of galactosyltransferase
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (2/2) O-methyltransferase domain
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00535 (2/2) Glycosyl transferase family 2
PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00037 (2/2) 4Fe-4S binding domain

precursor_groups_53738

2291.55 +- 1062.45

0.01 +- 0.01

PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13378 (2/2) Enolase C-terminal domain-like
PF12146 (2/2) Serine aminopeptidase, S33
PF08241 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (2/2) GH3 auxin-responsive promoter
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (2/2) Aconitase C-terminal domain
PF00330 (2/2) Aconitase family (aconitate hydratase)

precursor_groups_28574

274.58 +- 189.71

0.03 +- 0.05

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF08659 (2/2) KR domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF00698 (2/2) Acyl transferase domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_2083

224.43 +- 53.86

0.03 +- 0.04

PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01435 (3/3) Peptidase family M48
PF00775 (3/3) Dioxygenase
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00196 (3/3) Bacterial regulatory proteins, luxR family

precursor_groups_20660

144.72 +- 11.28

0.04 +- 0.04

PF13471 (2/2) Transglutaminase-like superfamily
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF00733 (2/2) Asparagine synthase

precursor_groups_1011

122.11 +- 96.49

0.03 +- 0.04

TIGR01840 (3/3) esterase, PHB depolymerase family
TIGR00666 (3/3) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (3/3) Protein of unknown function (DUF4232)
PF10503 (3/3) Esterase PHB depolymerase
PF02113 (3/3) D-Ala-D-Ala carboxypeptidase 3 (S13) family

precursor_groups_58650

454.25 +- 29.50

0.02 +- 0.02

TIGR00928 (2/2) adenylosuccinate lyase
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13454 (2/2) FAD-NAD(P)-binding
PF10397 (2/2) Adenylosuccinate lyase C-terminus
PF07969 (2/2) Amidohydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (2/2) Bacterial transcriptional activator domain
PF01425 (2/2) Amidase
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain

precursor_groups_5459

235.19 +- 41.40

0.02 +- 0.01

TIGR03920 (6/6) type VII secretion integral membrane protein EccD
TIGR03919 (6/6) type VII secretion protein EccB
PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD
PF07179 (6/6) SseB protein N-terminal domain
PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B
PF04488 (6/6) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (6/6) YbaB/EbfC DNA-binding family

precursor_groups_32866

197.39 +- 31.14

0.07 +- 0.11

TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (3/3) Domain of unknown function (DUF4380)
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13407 (3/3) Periplasmic binding protein domain
PF13378 (3/3) Enolase C-terminal domain-like
PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07729 (3/3) FCD domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (3/3) Branched-chain amino acid transport system / permease component
PF01081 (3/3) KDPG and KHG aldolase
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF00107 (3/3) Zinc-binding dehydrogenase
PF00005 (3/3) ABC transporter

precursor_groups_10155

174.09 +- 18.88

0.07 +- 0.09

PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5
PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF16355 (3/3) Domain of unknown function (DUF4982)
PF14310 (3/3) Fibronectin type III-like domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/3) alpha/beta hydrolase fold
PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain
PF00703 (3/3) Glycosyl hydrolases family 2

precursor_groups_28226

98.93 +- 27.86

0.05 +- 0.05

PF18085 (3/3) Maltokinase N-terminal cap domain
PF05547 (3/3) Immune inhibitor A peptidase M6
PF01433 (3/3) Peptidase family M1 domain
PF08241 (2/3) Methyltransferase domain
PF01183 (2/3) Glycosyl hydrolases family 25
PF00892 (2/3) EamA-like transporter family

precursor_groups_85472

390.00 +- 0.00

0.01 +- 0.00

PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (2/2) Flavin reductase like domain
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (2/2) Luciferase-like monooxygenase

precursor_groups_918

213.47 +- 171.99

0.02 +- 0.02

PF04055 (14/14) Radical SAM superfamily
PF07690 (13/14) Major Facilitator Superfamily
PF02897 (12/14) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (12/14) Prolyl oligopeptidase family

precursor_groups_28782

253.73 +- 93.57

0.05 +- 0.06

PF12802 (2/2) MarR family
PF09339 (2/2) IclR helix-turn-helix domain
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF04909 (1/2) Amidohydrolase
PF04199 (1/2) Putative cyclase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_15497

1363.59 +- 571.41

0.01 +- 0.01

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF13183 (2/2) 4Fe-4S dicluster domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (2/2) FCD domain
PF03737 (2/2) Aldolase/RraA
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02754 (2/2) Cysteine-rich domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (2/2) FAD binding domain
PF01229 (2/2) Glycosyl hydrolases family 39
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter

precursor_groups_20405

235.76 +- 54.49

0.08 +- 0.12

TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (2/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (2/2) Domain of unknown function (DUF4331)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF02882 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00925 (2/2) GTP cyclohydrolase II
PF00763 (2/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00107 (2/2) Zinc-binding dehydrogenase
PF00082 (2/2) Subtilase family

precursor_groups_37629

453.70 +- 99.16

0.03 +- 0.02

TIGR03296 (2/2) M6 family metalloprotease domain
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (2/2) ABC transporter

precursor_groups_1673

545.07 +- 292.47

0.04 +- 0.09

PF05147 (24/24) Lanthionine synthetase C-like protein
PF00664 (24/24) ABC transporter transmembrane region
PF00326 (24/24) Prolyl oligopeptidase family
PF00069 (24/24) Protein kinase domain
PF00005 (24/24) ABC transporter
PF04672 (23/24) S-adenosyl methyltransferase

precursor_groups_20705

261.23 +- 64.11

0.01 +- 0.01

PF13459 (5/5) 4Fe-4S single cluster domain
PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (5/5) TAP-like protein
PF03640 (5/5) Secreted repeat of unknown function
PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (5/5) alpha/beta hydrolase fold

precursor_groups_72197

895.44 +- 308.77

0.02 +- 0.03

TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF06339 (2/2) Ectoine synthase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (2/2) B12 binding domain
PF01841 (2/2) Transglutaminase-like superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_45090

194.50 +- 52.12

0.07 +- 0.08

TIGR00976 (2/2) hydrolase CocE/NonD family protein
TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13977 (2/2) BetI-type transcriptional repressor, C-terminal
PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (2/2) Major Facilitator Superfamily
PF04075 (2/2) F420H(2)-dependent quinone reductase
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00005 (2/2) ABC transporter
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase

precursor_groups_8543

47.10 +- 5.79

0.06 +- 0.05

TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain
PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02036 (3/3) SCP-2 sterol transfer family

precursor_groups_10436

3120.00 +- 0.00

0.01 +- 0.00

TIGR04245 (2/2) N-acyltransferase NodA
TIGR04243 (2/2) chitooligosaccharide deacetylase NodB
TIGR04242 (2/2) chitooligosaccharide synthase NodC
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02474 (2/2) Nodulation protein A (NodA)
PF01522 (2/2) Polysaccharide deacetylase
PF01061 (2/2) ABC-2 type transporter
PF00535 (2/2) Glycosyl transferase family 2
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter

precursor_groups_42674

291.05 +- 29.25

0.08 +- 0.18

TIGR01928 (2/2) o-succinylbenzoate synthase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF12831 (2/2) FAD dependent oxidoreductase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (2/2) CoA-transferase family III
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01381 (2/2) Helix-turn-helix
PF01380 (2/2) SIS domain
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter

precursor_groups_84552

122.27 +- 27.73

0.02 +- 0.01

PF04073 (2/2) Aminoacyl-tRNA editing domain
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00892 (2/2) EamA-like transporter family
PF00464 (2/2) Serine hydroxymethyltransferase
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF00082 (1/2) Subtilase family

precursor_groups_21947

420.25 +- 97.76

0.01 +- 0.00

PF03412 (4/4) Peptidase C39 family
PF00668 (4/4) Condensation domain
PF00664 (4/4) ABC transporter transmembrane region
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00005 (4/4) ABC transporter

precursor_groups_14303

191.56 +- 72.66

0.07 +- 0.11

TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF14224 (4/4) Domain of unknown function (DUF4331)
PF08240 (4/4) Alcohol dehydrogenase GroES-like domain
PF07690 (4/4) Major Facilitator Superfamily
PF00925 (4/4) GTP cyclohydrolase II
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00107 (4/4) Zinc-binding dehydrogenase
PF00082 (3/4) Subtilase family
PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

precursor_groups_1009

1097.05 +- 1032.42

0.03 +- 0.09

PF13575 (45/46) Domain of unknown function (DUF4135)
PF05147 (45/46) Lanthionine synthetase C-like protein
TIGR03897 (44/46) type 2 lantibiotic biosynthesis protein LanM
PF03412 (44/46) Peptidase C39 family
PF00664 (44/46) ABC transporter transmembrane region
PF00005 (44/46) ABC transporter
PF14867 (43/46) Lantibiotic alpha

precursor_groups_48611

52.32 +- 21.97

0.05 +- 0.02

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase

precursor_groups_16355

383.81 +- 168.05

0.01 +- 0.03

TIGR00702 (5/5) YcaO-type kinase domain
PF18029 (5/5) Glyoxalase-like domain
PF13489 (5/5) Methyltransferase domain
PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (5/5) TfuA-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding

precursor_groups_40542

328.15 +- 104.38

0.07 +- 0.16

TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain

precursor_groups_76415

96.37 +- 5.37

0.03 +- 0.04

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2

precursor_groups_42

40.24 +- 11.75

0.08 +- 0.17

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C

precursor_groups_42811

650.00 +- 0.00

0.01 +- 0.00

PF13367 (2/2) PrsW family intramembrane metalloprotease

precursor_groups_49

249.44 +- 156.55

0.05 +- 0.06

PF00005 (16/16) ABC transporter
PF00664 (14/16) ABC transporter transmembrane region
PF00069 (13/16) Protein kinase domain
PF05147 (9/16) Lanthionine synthetase C-like protein

precursor_groups_80550

1607.67 +- 212.33

0.01 +- 0.00

TIGR01733 (2/2) amino acid adenylation domain
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12844 (2/2) Helix-turn-helix domain
PF08892 (2/2) YqcI/YcgG family
PF07690 (2/2) Major Facilitator Superfamily
PF03486 (2/2) HI0933-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01636 (2/2) Phosphotransferase enzyme family
PF01409 (2/2) tRNA synthetases class II core domain (F)
PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF17874 (1/2) MalT-like TPR region

precursor_groups_51837

1068.75 +- 101.25

0.01 +- 0.00

PF13416 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF00962 (2/2) Adenosine/AMP deaminase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_50833

80.77 +- 3.37

0.06 +- 0.08

PF07690 (2/2) Major Facilitator Superfamily
PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (2/2) CoA-transferase family III
PF00932 (2/2) Lamin Tail Domain
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain

precursor_groups_15659

52.65 +- 10.40

0.06 +- 0.07

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain

precursor_groups_321

32.76 +- 4.10

0.06 +- 0.03

PF08007 (2/2) Cupin superfamily protein
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_6316

468.39 +- 239.31

0.03 +- 0.02

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13460 (3/3) NAD(P)H-binding
PF07690 (3/3) Major Facilitator Superfamily
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF01494 (3/3) FAD binding domain
PF00561 (3/3) alpha/beta hydrolase fold
TIGR00928 (2/3) adenylosuccinate lyase
PF13673 (2/3) Acetyltransferase (GNAT) domain
PF12800 (2/3) 4Fe-4S binding domain
PF01425 (2/3) Amidase
PF00486 (2/3) Transcriptional regulatory protein, C terminal
PF00206 (2/3) Lyase
PF00120 (2/3) Glutamine synthetase, catalytic domain
PF00072 (2/3) Response regulator receiver domain

precursor_groups_82367

322.38 +- 56.79

0.02 +- 0.02

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450

precursor_groups_5888

778.00 +- 2.83

0.01 +- 0.00

TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (3/3) SagB-type dehydrogenase domain
PF16058 (3/3) Mucin-like
PF07690 (3/3) Major Facilitator Superfamily
PF03972 (3/3) MmgE/PrpD family
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00675 (3/3) Insulinase (Peptidase family M16)

precursor_groups_733

5756.47 +- 1500.30

0.01 +- 0.01

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00005 (3/3) ABC transporter
TIGR01189 (2/3) heme ABC exporter, ATP-binding protein CcmA
PF12698 (2/3) ABC-2 family transporter protein

precursor_groups_730

1147.46 +- 656.81

0.02 +- 0.04

TIGR03897 (23/23) type 2 lantibiotic biosynthesis protein LanM
PF13575 (23/23) Domain of unknown function (DUF4135)
PF05147 (23/23) Lanthionine synthetase C-like protein
PF03412 (22/23) Peptidase C39 family
PF00664 (22/23) ABC transporter transmembrane region
PF00005 (22/23) ABC transporter
TIGR03898 (20/23) type 2 lantibiotic, mersacidin/lichenicidin family
PF12679 (14/23) ABC-2 family transporter protein

precursor_groups_83733

4608.81 +- 2021.19

0.02 +- 0.03

precursor_groups_2450

27.06 +- 5.19

0.09 +- 0.10

PF13516 (2/2) Leucine Rich repeat
PF13203 (2/2) Putative metallopeptidase domain
PF09967 (2/2) VWA-like domain (DUF2201)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF14435 (1/2) SUKH-4 immunity protein
PF12796 (1/2) Ankyrin repeats (3 copies)
PF01738 (1/2) Dienelactone hydrolase family

precursor_groups_46115

186.14 +- 8.86

0.03 +- 0.04

PF13564 (2/2) DoxX-like family
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF03358 (2/2) NADPH-dependent FMN reductase
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF18616 (1/2) CDI immunity proteins

precursor_groups_2515

339.13 +- 0.00

0.03 +- 0.01

TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1)
PF04679 (2/2) ATP dependent DNA ligase C terminal region
PF04675 (2/2) DNA ligase N terminus
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01380 (2/2) SIS domain
PF01068 (2/2) ATP dependent DNA ligase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_81827

516.00 +- 0.00

0.01 +- 0.00

PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent
PF03781 (2/2) Sulfatase-modifying factor enzyme 1
PF02450 (2/2) Lecithin:cholesterol acyltransferase
PF00400 (2/2) WD domain, G-beta repeat

precursor_groups_9139

7843.20 +- 6508.80

0.05 +- 0.15

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (2/2) amidohydrolase
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF07730 (2/2) Histidine kinase
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03412 (2/2) Peptidase C39 family
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (2/2) Peptidase family M20/M25/M40
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00664 (2/2) ABC transporter transmembrane region
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00067 (2/2) Cytochrome P450
PF00005 (2/2) ABC transporter
PF14310 (1/2) Fibronectin type III-like domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain

precursor_groups_14447

122.10 +- 43.38

0.05 +- 0.04

TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (4/4) amidohydrolase
TIGR00843 (4/4) benzoate transporter
PF13454 (4/4) FAD-NAD(P)-binding
PF13424 (4/4) Tetratricopeptide repeat
PF03594 (4/4) Benzoate membrane transport protein
PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (4/4) Peptidase family M20/M25/M40
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF00931 (4/4) NB-ARC domain
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme

precursor_groups_429

687.94 +- 313.54

0.02 +- 0.02

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00069 (3/3) Protein kinase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
PF00494 (2/3) Squalene/phytoene synthase

precursor_groups_32192

365.31 +- 284.69

0.03 +- 0.05

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase

precursor_groups_427

3858.25 +- 1997.49

0.02 +- 0.06

TIGR03882 (19/19) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (19/19) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (19/19) Lantibiotic biosynthesis dehydratase C-term
PF02624 (19/19) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (19/19) Nitroreductase family
PF00005 (13/19) ABC transporter
PF05402 (10/19) Coenzyme PQQ synthesis protein D (PqqD)

precursor_groups_12981

276.85 +- 62.50

0.02 +- 0.02

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family

precursor_groups_132

112.76 +- 103.65

0.05 +- 0.07

No common domains found

precursor_groups_67117

100.71 +- 10.71

0.06 +- 0.04

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_48975

292.50 +- 0.00

0.01 +- 0.00

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family

precursor_groups_42689

1292.60 +- 296.28

0.03 +- 0.02

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (2/2) Lantibiotic alpha
PF13575 (2/2) Domain of unknown function (DUF4135)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13556 (1/2) PucR C-terminal helix-turn-helix domain

precursor_groups_45864

1855.31 +- 282.62

0.04 +- 0.15

TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR01733 (3/3) amino acid adenylation domain
TIGR01686 (3/3) FkbH domain
TIGR00976 (3/3) hydrolase CocE/NonD family protein
PF18563 (3/3) TubC N-terminal docking domain
PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF13602 (3/3) Zinc-binding dehydrogenase
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08659 (3/3) KR domain
PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF03621 (3/3) MbtH-like protein
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02195 (3/3) ParB-like nuclease domain
PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (3/3) FAD dependent oxidoreductase
PF00975 (3/3) Thioesterase domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00668 (3/3) Condensation domain
PF00664 (3/3) ABC transporter transmembrane region
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF00005 (3/3) ABC transporter

precursor_groups_5499

174.02 +- 47.17

0.07 +- 0.10

PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF12680 (5/5) SnoaL-like domain
PF07045 (5/5) Domain of unknown function (DUF1330)
PF01738 (5/5) Dienelactone hydrolase family
PF00664 (5/5) ABC transporter transmembrane region
PF00440 (5/5) Bacterial regulatory proteins, tetR family
PF00005 (5/5) ABC transporter

precursor_groups_26684

444.94 +- 356.18

0.03 +- 0.04

PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain
PF03992 (4/4) Antibiotic biosynthesis monooxygenase
PF00664 (4/4) ABC transporter transmembrane region
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00248 (4/4) Aldo/keto reductase family
PF00005 (4/4) ABC transporter

precursor_groups_54637

69.96 +- 24.43

0.05 +- 0.09

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain

precursor_groups_12804

206.28 +- 77.96

0.09 +- 0.09

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (4/4) Alpha galactosidase A
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13378 (4/4) Enolase C-terminal domain-like
PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region
PF07729 (4/4) FCD domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF01081 (4/4) KDPG and KHG aldolase
PF00583 (4/4) Acetyltransferase (GNAT) family
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00294 (4/4) pfkB family carbohydrate kinase

precursor_groups_56365

433.58 +- 275.92

0.04 +- 0.03

TIGR00126 (2/2) deoxyribose-phosphate aldolase
PF13407 (2/2) Periplasmic binding protein domain
PF07702 (2/2) UTRA domain
PF05025 (2/2) RbsD / FucU transport protein family
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00005 (2/2) ABC transporter

precursor_groups_556

112.93 +- 162.01

0.04 +- 0.07

PF00733 (47/47) Asparagine synthase
PF13471 (46/47) Transglutaminase-like superfamily
PF05402 (46/47) Coenzyme PQQ synthesis protein D (PqqD)

precursor_groups_6671

258.67 +- 0.94

0.01 +- 0.00

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_13764

233.66 +- 123.26

0.02 +- 0.03

PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF05922 (4/4) Peptidase inhibitor I9
PF00535 (4/4) Glycosyl transferase family 2
PF00440 (4/4) Bacterial regulatory proteins, tetR family
PF00082 (4/4) Subtilase family

precursor_groups_12543

129.86 +- 93.00

0.05 +- 0.10

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_5653

964.27 +- 325.73

0.01 +- 0.02

PF10502 (2/2) Signal peptidase, peptidase S26
PF03704 (2/2) Bacterial transcriptional activator domain
PF00931 (2/2) NB-ARC domain
PF00899 (2/2) ThiF family
PF00717 (2/2) Peptidase S24-like
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter
TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF11271 (1/2) Porin PorA
PF07291 (1/2) Methylamine utilisation protein MauE
PF00440 (1/2) Bacterial regulatory proteins, tetR family

precursor_groups_75740

1430.00 +- 130.00

0.01 +- 0.00

TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
PF18105 (2/2) PGM1 C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF06969 (2/2) HemN C-terminal domain
PF05977 (2/2) Transmembrane secretion effector
PF04055 (2/2) Radical SAM superfamily
PF02543 (2/2) Carbamoyltransferase N-terminus
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00425 (2/2) chorismate binding enzyme
PF00117 (2/2) Glutamine amidotransferase class-I
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain

precursor_groups_819

59.27 +- 22.81

0.04 +- 0.07

PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08241 (4/4) Methyltransferase domain
PF04205 (4/4) FMN-binding domain
PF02424 (4/4) ApbE family
PF01794 (4/4) Ferric reductase like transmembrane component
PF00175 (4/4) Oxidoreductase NAD-binding domain

precursor_groups_50706

129.50 +- 0.50

0.02 +- 0.00

PF12708 (2/2) Pectate lyase superfamily protein
PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase
PF01120 (2/2) Alpha-L-fucosidase
PF00754 (2/2) F5/8 type C domain
PF00295 (2/2) Glycosyl hydrolases family 28

precursor_groups_62248

77.60 +- 25.60

0.03 +- 0.02

PF14525 (2/2) AraC-binding-like domain
PF12833 (2/2) Helix-turn-helix domain
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01551 (2/2) Peptidase family M23
PF01471 (2/2) Putative peptidoglycan binding domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase

precursor_groups_19855

277.22 +- 74.60

0.08 +- 0.08

precursor_groups_64908

516.00 +- 258.00

0.02 +- 0.03

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

precursor_groups_10742

114.31 +- 18.14

0.08 +- 0.04

PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00266 (2/2) Aminotransferase class-V

precursor_groups_2334

222.67 +- 78.34

0.03 +- 0.02

TIGR03930 (11/11) WXG100 family type VII secretion target
TIGR03920 (11/11) type VII secretion integral membrane protein EccD
TIGR03919 (11/11) type VII secretion protein EccB
PF15644 (11/11) Papain fold toxin 1, glutamine deamidase
PF08817 (11/11) WXG100 protein secretion system (Wss), protein YukD
PF07179 (11/11) SseB protein N-terminal domain
PF06013 (11/11) Proteins of 100 residues with WXG
PF05108 (11/11) Type VII secretion system ESX-1, transport TM domain B
PF02575 (11/11) YbaB/EbfC DNA-binding family
PF00652 (11/11) Ricin-type beta-trefoil lectin domain

precursor_groups_1282

192.97 +- 127.67

0.05 +- 0.03

TIGR04451 (14/14) lantipeptide, SCO0268 family
TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term
PF05147 (14/14) Lanthionine synthetase C-like protein
PF04738 (14/14) Lantibiotic dehydratase, N terminus
PF12802 (9/14) MarR family
PF12697 (9/14) Alpha/beta hydrolase family
PF02065 (9/14) Melibiase
PF01547 (9/14) Bacterial extracellular solute-binding protein
PF00528 (9/14) Binding-protein-dependent transport system inner membrane component
PF00480 (9/14) ROK family
PF02894 (8/14) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/14) Oxidoreductase family, NAD-binding Rossmann fold

precursor_groups_29741

336.40 +- 91.11

0.01 +- 0.01

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain

precursor_groups_1446

48.54 +- 0.65

0.08 +- 0.17

TIGR03296 (2/2) M6 family metalloprotease domain
PF09339 (2/2) IclR helix-turn-helix domain
PF03777 (2/2) ChpA-C

precursor_groups_21578

108.35 +- 37.40

0.09 +- 0.06

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_15041

226.53 +- 46.37

0.07 +- 0.11

TIGR00711 (3/3) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (3/3) Tetracyclin repressor-like, C-terminal domain
PF14224 (3/3) Domain of unknown function (DUF4331)
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00925 (3/3) GTP cyclohydrolase II
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00107 (3/3) Zinc-binding dehydrogenase
PF00082 (3/3) Subtilase family
PF02882 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF00763 (2/3) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

precursor_groups_50390

3194.97 +- 210.63

0.02 +- 0.01

precursor_groups_15049

2401.56 +- 1135.16

0.02 +- 0.01

TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (3/3) ATP-grasp domain
PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (3/3) Prephenate dehydrogenase
PF01613 (3/3) Flavin reductase like domain
PF01070 (3/3) FMN-dependent dehydrogenase
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00155 (3/3) Aminotransferase class I and II
PF00106 (3/3) short chain dehydrogenase
PF18130 (2/3) ATP-grasp N-terminal domain

precursor_groups_52507

134.01 +- 78.72

0.06 +- 0.05

PF13471 (2/2) Transglutaminase-like superfamily
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF07591 (1/2) Pretoxin HINT domain
PF05593 (1/2) RHS Repeat

precursor_groups_9354

479.19 +- 156.31

0.02 +- 0.01

PF07690 (9/9) Major Facilitator Superfamily
PF04055 (9/9) Radical SAM superfamily
PF03466 (9/9) LysR substrate binding domain
PF02310 (9/9) B12 binding domain
PF00733 (9/9) Asparagine synthase
PF00501 (9/9) AMP-binding enzyme
PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_64010

117.00 +- 13.00

0.02 +- 0.01

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold

precursor_groups_36155

216.00 +- 44.00

0.01 +- 0.00

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain

precursor_groups_72354

69.81 +- 25.74

0.07 +- 0.06

PF07690 (2/2) Major Facilitator Superfamily
PF05893 (2/2) Acyl-CoA reductase (LuxC)
PF04443 (2/2) Acyl-protein synthetase, LuxE
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00501 (2/2) AMP-binding enzyme

precursor_groups_2029

291.55 +- 224.45

0.03 +- 0.06

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_10969

877.59 +- 552.41

0.02 +- 0.06

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF17914 (2/2) HopA1 effector protein family
PF13469 (2/2) Sulfotransferase family
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_39

50.96 +- 24.18

0.05 +- 0.03

PF13520 (3/3) Amino acid permease
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family

precursor_groups_585

93.44 +- 9.76

0.04 +- 0.07

PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF03575 (2/2) Peptidase family S51
PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold

precursor_groups_1347

2220.43 +- 119.57

0.01 +- 0.00

precursor_groups_14643

660.47 +- 112.74

0.01 +- 0.01

TIGR01733 (7/7) amino acid adenylation domain
PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (7/7) Ketoacyl-synthetase C-terminal extension
PF13535 (7/7) ATP-grasp domain
PF13193 (7/7) AMP-binding enzyme C-terminal domain
PF12706 (7/7) Beta-lactamase superfamily domain
PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain
PF01636 (7/7) Phosphotransferase enzyme family
PF00975 (7/7) Thioesterase domain
PF00698 (7/7) Acyl transferase domain
PF00668 (7/7) Condensation domain
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00326 (7/7) Prolyl oligopeptidase family
PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_6914

73.12 +- 24.38

0.03 +- 0.02

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein

precursor_groups_10887

157.25 +- 62.23

0.07 +- 0.19

PF13191 (4/4) AAA ATPase domain
PF10502 (4/4) Signal peptidase, peptidase S26
PF07291 (4/4) Methylamine utilisation protein MauE
PF00717 (4/4) Peptidase S24-like
PF00005 (4/4) ABC transporter
PF02254 (3/4) TrkA-N domain
PF01242 (3/4) 6-pyruvoyl tetrahydropterin synthase
PF00664 (3/4) ABC transporter transmembrane region
PF13181 (2/4) Tetratricopeptide repeat

precursor_groups_9177

91.00 +- 39.00

0.03 +- 0.02

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase

precursor_groups_52435

1163.94 +- 693.66

0.02 +- 0.01

TIGR03561 (2/2) peroxiredoxin, Ohr subfamily
PF13649 (2/2) Methyltransferase domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (2/2) IclR helix-turn-helix domain
PF09084 (2/2) NMT1/THI5 like
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF04199 (2/2) Putative cyclase
PF03972 (2/2) MmgE/PrpD family
PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (2/2) OsmC-like protein
PF02515 (2/2) CoA-transferase family III
PF01979 (2/2) Amidohydrolase family
PF01614 (2/2) Bacterial transcriptional regulator
PF01546 (2/2) Peptidase family M20/M25/M40
PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_20284

98.93 +- 27.86

0.05 +- 0.05

precursor_groups_12012

858.49 +- 193.39

0.01 +- 0.00

TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (4/4) HlyD family secretion protein
PF03412 (4/4) Peptidase C39 family
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter

precursor_groups_68571

24.72 +- 1.08

0.08 +- 0.08

PF10923 (2/2) P-loop Domain of unknown function (DUF2791)
PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF00271 (2/2) Helicase conserved C-terminal domain
PF00270 (2/2) DEAD/DEAH box helicase

precursor_groups_1193

133.51 +- 85.83

0.03 +- 0.02

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like

precursor_groups_68779

362.00 +- 154.00

0.01 +- 0.01

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

precursor_groups_22154

1767.52 +- 216.09

0.01 +- 0.02

TIGR00702 (3/3) YcaO-type kinase domain
PF13302 (3/3) Acetyltransferase (GNAT) domain
PF08007 (3/3) Cupin superfamily protein
PF07812 (3/3) TfuA-like protein
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00326 (3/3) Prolyl oligopeptidase family

precursor_groups_170

250.91 +- 0.64

0.07 +- 0.08

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
PF00171 (2/2) Aldehyde dehydrogenase family
TIGR02258 (1/2) 2'-5' RNA ligase
TIGR00517 (1/2) acyl carrier protein
PF14310 (1/2) Fibronectin type III-like domain
PF13802 (1/2) Galactose mutarotase-like
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13377 (1/2) Periplasmic binding protein-like domain
PF08386 (1/2) TAP-like protein
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF07555 (1/2) beta-N-acetylglucosaminidase
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02838 (1/2) Glycosyl hydrolase family 20, domain 2
PF02834 (1/2) LigT like Phosphoesterase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01381 (1/2) Helix-turn-helix
PF01055 (1/2) Glycosyl hydrolases family 31
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00668 (1/2) Condensation domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00296 (1/2) Luciferase-like monooxygenase
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_174

500.84 +- 250.71

0.02 +- 0.05

TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM
PF13575 (5/5) Domain of unknown function (DUF4135)
PF13191 (5/5) AAA ATPase domain
PF05147 (5/5) Lanthionine synthetase C-like protein
PF03704 (5/5) Bacterial transcriptional activator domain
PF00931 (5/5) NB-ARC domain
PF00486 (5/5) Transcriptional regulatory protein, C terminal
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13185 (4/5) GAF domain
PF08448 (4/5) PAS fold
PF07228 (4/5) Stage II sporulation protein E (SpoIIE)

precursor_groups_21393

152.71 +- 40.50

0.02 +- 0.01

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain

precursor_groups_10707

221.77 +- 79.53

0.05 +- 0.04

TIGR00976 (9/9) hydrolase CocE/NonD family protein
PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (9/9) alpha/beta hydrolase fold
PF07690 (9/9) Major Facilitator Superfamily
PF03781 (9/9) Sulfatase-modifying factor enzyme 1
PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (9/9) Phosphotriesterase family
PF01494 (9/9) FAD binding domain
PF00884 (9/9) Sulfatase
PF00753 (9/9) Metallo-beta-lactamase superfamily

precursor_groups_48835

1029.17 +- 97.50

0.01 +- 0.01

PF12146 (2/2) Serine aminopeptidase, S33
PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF09924 (2/2) Uncharacterised conserved protein (DUF2156)
PF08448 (2/2) PAS fold
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01613 (2/2) Flavin reductase like domain
PF00899 (2/2) ThiF family
PF00202 (2/2) Aminotransferase class-III
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_5265

2176.88 +- 2360.36

0.01 +- 0.01

TIGR03897 (4/4) type 2 lantibiotic biosynthesis protein LanM
PF14867 (4/4) Lantibiotic alpha
PF13575 (4/4) Domain of unknown function (DUF4135)
PF05147 (4/4) Lanthionine synthetase C-like protein
PF03412 (4/4) Peptidase C39 family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF00296 (3/4) Luciferase-like monooxygenase

precursor_groups_2240

250.40 +- 9.60

0.02 +- 0.02

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

precursor_groups_2244

196.89 +- 6.51

0.04 +- 0.15

TIGR01558 (4/4) putative phage terminase, small subunit, P27 family
TIGR01554 (4/4) phage major capsid protein, HK97 family
TIGR01543 (4/4) phage prohead protease, HK97 family
TIGR01537 (4/4) phage portal protein, HK97 family
PF16945 (4/4) Putative lactococcus lactis phage r1t holin
PF13229 (4/4) Right handed beta helix region
PF10145 (4/4) Phage-related minor tail protein
PF05119 (4/4) Phage terminase, small subunit
PF05065 (4/4) Phage capsid family
PF04860 (4/4) Phage portal protein
PF04586 (4/4) Caudovirus prohead serine protease
PF03354 (4/4) Phage Terminase
PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase
PF01476 (4/4) LysM domain
PF01464 (4/4) Transglycosylase SLT domain
PF01381 (4/4) Helix-turn-helix

precursor_groups_19605

157.71 +- 71.71

0.04 +- 0.08

TIGR01733 (2/2) amino acid adenylation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12146 (2/2) Serine aminopeptidase, S33
PF07690 (2/2) Major Facilitator Superfamily
PF01425 (2/2) Amidase
PF01042 (2/2) Endoribonuclease L-PSP
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme

precursor_groups_450

27.25 +- 2.74

0.07 +- 0.09

PF13244 (9/9) Domain of unknown function (DUF4040)
PF12840 (9/9) Helix-turn-helix domain
PF04066 (9/9) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (9/9) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (9/9) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (9/9) Proton-conducting membrane transporter

precursor_groups_43009

109.51 +- 1.92

0.04 +- 0.03

PF04167 (2/2) Protein of unknown function (DUF402)
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00144 (2/2) Beta-lactamase
PF00082 (2/2) Subtilase family

precursor_groups_108

126.20 +- 2.80

0.05 +- 0.05

PF13088 (2/2) BNR repeat-like domain
TIGR03444 (1/2) ergothioneine biosynthesis glutamate--cysteine ligase EgtA
TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13641 (1/2) Glycosyltransferase like family 2
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13520 (1/2) Amino acid permease
PF11695 (1/2) Domain of unknown function (DUF3291)
PF04978 (1/2) Protein of unknown function (DUF664)
PF04264 (1/2) YceI-like domain
PF04248 (1/2) Domain of unknown function (DUF427)
PF04237 (1/2) YjbR
PF04107 (1/2) Glutamate-cysteine ligase family 2(GCS2)
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain

precursor_groups_6137

726.94 +- 148.59

0.02 +- 0.02

PF17914 (6/6) HopA1 effector protein family
PF13649 (6/6) Methyltransferase domain
PF05193 (6/6) Peptidase M16 inactive domain
PF02441 (6/6) Flavoprotein
PF00675 (6/6) Insulinase (Peptidase family M16)
PF00296 (6/6) Luciferase-like monooxygenase
PF00005 (6/6) ABC transporter

precursor_groups_513

297.75 +- 125.22

0.02 +- 0.03

TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD
TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C
TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF12706 (3/3) Beta-lactamase superfamily domain
PF07995 (3/3) Glucose / Sorbosone dehydrogenase
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (3/3) Radical SAM superfamily
PF03070 (3/3) TENA/THI-4/PQQC family
TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA

precursor_groups_31875

152.80 +- 39.15

0.03 +- 0.02

PF13377 (3/3) Periplasmic binding protein-like domain
PF13185 (3/3) GAF domain
PF08448 (3/3) PAS fold
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF00356 (3/3) Bacterial regulatory proteins, lacI family

precursor_groups_100

634.11 +- 416.96

0.05 +- 0.08

TIGR04364 (8/8) methyltransferase, FxLD system
TIGR04363 (8/8) FxLD family lantipeptide
TIGR03891 (8/8) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (8/8) Lantibiotic biosynthesis dehydratase C-term
PF05147 (8/8) Lanthionine synthetase C-like protein
PF04738 (8/8) Lantibiotic dehydratase, N terminus
PF01135 (8/8) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF05331 (7/8) Protein of unknown function (DUF742)
PF03259 (7/8) Roadblock/LC7 domain
PF03029 (7/8) Conserved hypothetical ATP binding protein
PF01427 (7/8) D-ala-D-ala dipeptidase
PF00293 (7/8) NUDIX domain
PF00196 (7/8) Bacterial regulatory proteins, luxR family
PF00005 (7/8) ABC transporter
PF02771 (5/8) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/8) Acyl-CoA dehydrogenase, middle domain
PF01590 (5/8) GAF domain
PF00723 (5/8) Glycosyl hydrolases family 15
PF00441 (5/8) Acyl-CoA dehydrogenase, C-terminal domain
PF13671 (4/8) AAA domain
PF02518 (4/8) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

precursor_groups_22572

473.90 +- 383.28

0.06 +- 0.20

TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
PF13632 (4/4) Glycosyl transferase family group 2
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13191 (4/4) AAA ATPase domain
PF12710 (4/4) haloacid dehalogenase-like hydrolase
PF07690 (4/4) Major Facilitator Superfamily
PF04321 (4/4) RmlD substrate binding domain
PF01979 (4/4) Amidohydrolase family
PF00535 (4/4) Glycosyl transferase family 2
PF00480 (4/4) ROK family
PF00459 (4/4) Inositol monophosphatase family
PF00294 (4/4) pfkB family carbohydrate kinase
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
TIGR00178 (3/4) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/4) Monomeric isocitrate dehydrogenase
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_1833

328.63 +- 21.56

0.03 +- 0.03

PF13471 (3/3) Transglutaminase-like superfamily
PF01546 (3/3) Peptidase family M20/M25/M40
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter

precursor_groups_298

359.72 +- 141.51

0.02 +- 0.04

PF07739 (6/6) TipAS antibiotic-recognition domain
PF07690 (6/6) Major Facilitator Superfamily
PF07228 (6/6) Stage II sporulation protein E (SpoIIE)
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF13411 (5/6) MerR HTH family regulatory protein
PF01551 (5/6) Peptidase family M23

precursor_groups_3023

325.00 +- 239.00

0.03 +- 0.08

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (3/3) SPFH domain / Band 7 family
PF00877 (3/3) NlpC/P60 family

precursor_groups_295

1775.87 +- 1261.12

0.04 +- 0.14

PF13649 (4/4) Methyltransferase domain
PF12730 (4/4) ABC-2 family transporter protein
PF00465 (4/4) Iron-containing alcohol dehydrogenase
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
PF05147 (3/4) Lanthionine synthetase C-like protein

precursor_groups_26658

516.88 +- 343.12

0.04 +- 0.11

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (2/2) 3-isopropylmalate dehydrogenase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF11806 (2/2) Domain of unknown function (DUF3327)
PF08242 (2/2) Methyltransferase domain
PF03621 (2/2) MbtH-like protein
PF00756 (2/2) Putative esterase
PF00694 (2/2) Aconitase C-terminal domain
PF00682 (2/2) HMGL-like
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00330 (2/2) Aconitase family (aconitate hydratase)
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
PF00155 (2/2) Aminotransferase class I and II

precursor_groups_67341

447.87 +- 22.41

0.04 +- 0.02

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_5466

48.84 +- 15.40

0.09 +- 0.08

TIGR00072 (2/2) hydrogenase maturation protease
PF17179 (2/2) 4Fe-4S dicluster domain
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF01750 (2/2) Hydrogenase maturation protease
PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit
PF00374 (2/2) Nickel-dependent hydrogenase
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00027 (2/2) Cyclic nucleotide-binding domain

precursor_groups_84495

1040.00 +- 0.00

0.01 +- 0.00

TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF03358 (2/2) NADPH-dependent FMN reductase
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00675 (2/2) Insulinase (Peptidase family M16)

precursor_groups_84497

4695.60 +- 0.00

0.01 +- 0.00

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01189 (2/2) heme ABC exporter, ATP-binding protein CcmA
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF12698 (2/2) ABC-2 family transporter protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter

precursor_groups_58293

961.71 +- 70.29

0.01 +- 0.00

PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF08386 (2/2) TAP-like protein
PF07732 (2/2) Multicopper oxidase
PF07731 (2/2) Multicopper oxidase
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF01979 (2/2) Amidohydrolase family
PF00561 (2/2) alpha/beta hydrolase fold
PF00394 (2/2) Multicopper oxidase

precursor_groups_2742

187.56 +- 79.93

0.03 +- 0.04

PF06628 (4/4) Catalase-related immune-responsive
PF01475 (4/4) Ferric uptake regulator family
PF00248 (4/4) Aldo/keto reductase family
PF00199 (4/4) Catalase
PF08240 (2/4) Alcohol dehydrogenase GroES-like domain

precursor_groups_48573

3194.97 +- 210.63

0.02 +- 0.01

precursor_groups_65596

175.06 +- 37.41

0.03 +- 0.04

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (2/2) LytR cell envelope-related transcriptional attenuator
PF07859 (2/2) alpha/beta hydrolase fold
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent
PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00459 (2/2) Inositol monophosphatase family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family

precursor_groups_11811

125.11 +- 36.14

0.05 +- 0.06

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (2/2) HAMP domain
PF00553 (2/2) Cellulose binding domain
PF00512 (2/2) His Kinase A (phospho-acceptor) domain
TIGR01766 (1/2) transposase, IS605 OrfB family
PF07282 (1/2) Putative transposase DNA-binding domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01385 (1/2) Probable transposase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain

precursor_groups_68952

961.71 +- 70.29

0.01 +- 0.00

precursor_groups_7713

125.11 +- 36.14

0.05 +- 0.06

precursor_groups_14797

47.52 +- 9.22

0.04 +- 0.05

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2

precursor_groups_69133

647.50 +- 2.50

0.01 +- 0.00

TIGR03923 (2/2) type VII secretion protein EccE
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal
PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03640 (2/2) Secreted repeat of unknown function
PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily
PF00082 (2/2) Subtilase family

precursor_groups_11727

272.98 +- 0.99

0.09 +- 0.18

TIGR03797 (3/3) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (3/3) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/3) Major Facilitator Superfamily
PF05013 (3/3) N-formylglutamate amidohydrolase
PF03412 (3/3) Peptidase C39 family
PF03055 (3/3) Retinal pigment epithelial membrane protein
PF00664 (3/3) ABC transporter transmembrane region
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00005 (3/3) ABC transporter
PF13437 (2/3) HlyD family secretion protein

precursor_groups_73777

149.12 +- 39.59

0.06 +- 0.02

PF16353 (2/2) Domain of unknown function(DUF4981)
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component

precursor_groups_49943

347.93 +- 153.74

0.05 +- 0.08

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_639

398.21 +- 55.58

0.07 +- 0.08

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (6/6) SagB-type dehydrogenase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF13191 (6/6) AAA ATPase domain
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF03704 (6/6) Bacterial transcriptional activator domain
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (6/6) ABC-2 type transporter
PF00881 (6/6) Nitroreductase family
PF00486 (6/6) Transcriptional regulatory protein, C terminal
PF00005 (6/6) ABC transporter

precursor_groups_12109

150.50 +- 136.83

0.03 +- 0.02

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)

precursor_groups_61909

773.17 +- 20.67

0.01 +- 0.00

TIGR01926 (2/2) uncharacterized peroxidase-related enzyme
PF13454 (2/2) FAD-NAD(P)-binding
PF13343 (2/2) Bacterial extracellular solute-binding protein
PF08402 (2/2) TOBE domain
PF02627 (2/2) Carboxymuconolactone decarboxylase family
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter

precursor_groups_35315

582.00 +- 192.00

0.01 +- 0.01

PF13191 (2/2) AAA ATPase domain
PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (2/2) Putative Ig domain
PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (2/2) PA domain
PF01638 (2/2) HxlR-like helix-turn-helix
PF01483 (2/2) Proprotein convertase P-domain
PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family

precursor_groups_25675

172.00 +- 60.81

0.01 +- 0.00

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase

precursor_groups_9823

404.91 +- 183.77

0.07 +- 0.11

PF18604 (2/2) Pre ATP-grasp domain
PF18105 (2/2) PGM1 C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
TIGR01249 (1/2) prolyl aminopeptidase
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF07366 (1/2) SnoaL-like polyketide cyclase
PF04203 (1/2) Sortase domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01610 (1/2) Transposase
PF01381 (1/2) Helix-turn-helix
PF00672 (1/2) HAMP domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00561 (1/2) alpha/beta hydrolase fold
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00400 (1/2) WD domain, G-beta repeat
PF00072 (1/2) Response regulator receiver domain

precursor_groups_84405

1105.00 +- 0.00

0.02 +- 0.00

PF16353 (2/2) Domain of unknown function(DUF4981)
PF13378 (2/2) Enolase C-terminal domain-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF06452 (2/2) Carbohydrate family 9 binding domain-like
PF02929 (2/2) Beta galactosidase small chain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_23621

394.50 +- 74.31

0.02 +- 0.03

PF08386 (5/5) TAP-like protein
PF07690 (5/5) Major Facilitator Superfamily
PF01979 (5/5) Amidohydrolase family
PF00561 (5/5) alpha/beta hydrolase fold
PF00326 (5/5) Prolyl oligopeptidase family
PF13649 (3/5) Methyltransferase domain

precursor_groups_4069

27.10 +- 6.92

0.08 +- 0.07

TIGR01249 (3/3) prolyl aminopeptidase
PF07470 (3/3) Glycosyl Hydrolase Family 88
PF00561 (3/3) alpha/beta hydrolase fold

precursor_groups_52985

91.60 +- 0.33

0.10 +- 0.29

TIGR01733 (2/2) amino acid adenylation domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF05977 (2/2) Transmembrane secretion effector
PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01842 (2/2) ACT domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00742 (2/2) Homoserine dehydrogenase
PF00698 (2/2) Acyl transferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (2/2) Cytochrome P450

precursor_groups_1547

2852.98 +- 1813.19

0.01 +- 0.01

TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (12/13) Nitroreductase family
TIGR03605 (11/13) SagB-type dehydrogenase domain
PF04738 (10/13) Lantibiotic dehydratase, N terminus
PF00067 (8/13) Cytochrome P450
PF00440 (7/13) Bacterial regulatory proteins, tetR family

precursor_groups_16719

137.60 +- 68.80

0.06 +- 0.05

PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain

precursor_groups_52076

139.98 +- 39.33

0.04 +- 0.04

PF07702 (2/2) UTRA domain
PF04672 (2/2) S-adenosyl methyltransferase
PF03747 (2/2) ADP-ribosylglycohydrolase
PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_50588

250.40 +- 9.60

0.02 +- 0.02

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

precursor_groups_71689

344.00 +- 0.00

0.03 +- 0.02

PF07690 (2/2) Major Facilitator Superfamily
PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA)
PF00561 (2/2) alpha/beta hydrolase fold
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase

precursor_groups_74379

3120.00 +- 0.00

0.01 +- 0.00

precursor_groups_63001

105.74 +- 24.26

0.03 +- 0.03

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme

precursor_groups_1380

744.35 +- 495.10

0.02 +- 0.02

TIGR04504 (3/3) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (3/3) mycofactocin precursor
TIGR03967 (3/3) putative mycofactocin binding protein MftB
TIGR03966 (3/3) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (3/3) mycofactocin system glycosyltransferase
TIGR03964 (3/3) mycofactocin system creatininase family protein
TIGR03962 (3/3) mycofactocin radical SAM maturase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13186 (3/3) Iron-sulfur cluster-binding domain
PF04055 (3/3) Radical SAM superfamily
PF02633 (3/3) Creatinine amidohydrolase
PF01070 (3/3) FMN-dependent dehydrogenase
PF00535 (3/3) Glycosyl transferase family 2
PF17676 (2/3) LD-carboxypeptidase C-terminal domain
PF16861 (2/3) Carbamoyltransferase C-terminus
PF13489 (2/3) Methyltransferase domain
PF08242 (2/3) Methyltransferase domain
PF03129 (2/3) Anticodon binding domain
PF02543 (2/3) Carbamoyltransferase N-terminus
PF02016 (2/3) LD-carboxypeptidase N-terminal domain
PF01980 (2/3) tRNA-methyltransferase O
PF01041 (2/3) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/3) tRNA synthetase class II core domain (G, H, P, S and T)
PF00152 (2/3) tRNA synthetases class II (D, K and N)
PF00067 (2/3) Cytochrome P450

precursor_groups_25018

212.38 +- 67.73

0.04 +- 0.06

TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF10025 (3/3) Uncharacterized conserved protein (DUF2267)
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00067 (3/3) Cytochrome P450

precursor_groups_6246

1991.35 +- 896.21

0.02 +- 0.10

TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (5/5) diaminopimelate epimerase
PF18603 (5/5) L-amino acid ligase C-terminal domain 2
PF18130 (5/5) ATP-grasp N-terminal domain
PF14518 (5/5) Iron-containing redox enzyme
PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (5/5) ATP-grasp domain
PF13458 (5/5) Periplasmic binding protein
PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (5/5) 2OG-Fe dioxygenase
PF08241 (5/5) Methyltransferase domain
PF07859 (5/5) alpha/beta hydrolase fold
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (5/5) Aminopeptidase P, N-terminal domain
PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family
PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (5/5) Prephenate dehydrogenase
PF01678 (5/5) Diaminopimelate epimerase
PF01575 (5/5) MaoC like domain
PF01568 (5/5) Molydopterin dinucleotide binding domain
PF01425 (5/5) Amidase
PF01070 (5/5) FMN-dependent dehydrogenase
PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (5/5) EamA-like transporter family
PF00682 (5/5) HMGL-like
PF00557 (5/5) Metallopeptidase family M24
PF00384 (5/5) Molybdopterin oxidoreductase
PF00248 (5/5) Aldo/keto reductase family
PF00155 (5/5) Aminotransferase class I and II
PF00005 (5/5) ABC transporter

precursor_groups_20824

1582.13 +- 391.36

0.03 +- 0.04

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00747 (2/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF10862 (2/2) FcoT-like thioesterase domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (2/2) Sigma-70, region 4
PF07993 (2/2) Male sterility protein
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03929 (2/2) PepSY-associated TM region
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (2/2) DJ-1/PfpI family
PF01794 (2/2) Ferric reductase like transmembrane component
PF01497 (2/2) Periplasmic binding protein
PF01032 (2/2) FecCD transport family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00005 (2/2) ABC transporter

precursor_groups_10459

128.12 +- 45.26

0.08 +- 0.18

TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (4/4) amino acid adenylation domain
PF16197 (4/4) Ketoacyl-synthetase C-terminal extension
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07690 (4/4) Major Facilitator Superfamily
PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02127 (4/4) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (4/4) Thioesterase domain
PF00877 (4/4) NlpC/P60 family
PF00698 (4/4) Acyl transferase domain
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00296 (4/4) Luciferase-like monooxygenase
PF00202 (4/4) Aminotransferase class-III
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
PF12158 (2/4) Protein of unknown function (DUF3592)
PF01145 (2/4) SPFH domain / Band 7 family

precursor_groups_22684

618.09 +- 123.82

0.01 +- 0.02

TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase
PF17676 (5/5) LD-carboxypeptidase C-terminal domain
PF16715 (5/5) Cyclodipeptide synthase
PF13847 (5/5) Methyltransferase domain
PF13576 (5/5) Pentapeptide repeats (9 copies)
PF13535 (5/5) ATP-grasp domain
PF07690 (5/5) Major Facilitator Superfamily
PF04055 (5/5) Radical SAM superfamily
PF02310 (5/5) B12 binding domain
PF02016 (5/5) LD-carboxypeptidase N-terminal domain
PF01636 (5/5) Phosphotransferase enzyme family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00155 (5/5) Aminotransferase class I and II
PF00152 (5/5) tRNA synthetases class II (D, K and N)
PF00067 (5/5) Cytochrome P450

precursor_groups_37828

760.47 +- 374.44

0.04 +- 0.12

precursor_groups_5898

203.13 +- 221.37

0.05 +- 0.10

PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (6/6) BFD-like [2Fe-2S] binding domain
PF02782 (6/6) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (6/6) FAD dependent oxidoreductase
PF00370 (6/6) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (4/6) NUDIX domain

precursor_groups_25793

694.47 +- 44.47

0.01 +- 0.00

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
PF13649 (2/2) Methyltransferase domain
PF07690 (2/2) Major Facilitator Superfamily
PF05193 (2/2) Peptidase M16 inactive domain
PF04989 (2/2) Cephalosporin hydroxylase
PF04055 (2/2) Radical SAM superfamily
PF02310 (2/2) B12 binding domain
PF00805 (2/2) Pentapeptide repeats (8 copies)
PF00675 (2/2) Insulinase (Peptidase family M16)

precursor_groups_76314

100.28 +- 9.84

0.06 +- 0.06

PF14903 (2/2) WG containing repeat
PF10042 (2/2) Uncharacterized conserved protein (DUF2278)
PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (2/2) ABC 3 transport family
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00005 (2/2) ABC transporter

precursor_groups_25791

685.57 +- 53.59

0.07 +- 0.22

TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR01356 (4/4) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (4/4) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (4/4) ATP-grasp domain
PF13535 (4/4) ATP-grasp domain
PF13480 (4/4) Acetyltransferase (GNAT) domain
PF13115 (4/4) YtkA-like
PF04389 (4/4) Peptidase family M28
PF02627 (4/4) Carboxymuconolactone decarboxylase family
PF01676 (4/4) Metalloenzyme superfamily
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00664 (4/4) ABC transporter transmembrane region
PF00403 (4/4) Heavy-metal-associated domain
PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (4/4) Aminotransferase class I and II
PF00122 (4/4) E1-E2 ATPase
PF00117 (4/4) Glutamine amidotransferase class-I
PF00005 (4/4) ABC transporter
PF02222 (2/4) ATP-grasp domain

precursor_groups_63090

237.03 +- 98.37

0.02 +- 0.04

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03920 (2/2) type VII secretion integral membrane protein EccD
TIGR03919 (2/2) type VII secretion protein EccB
PF15644 (2/2) Papain fold toxin 1, glutamine deamidase
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (2/2) YbaB/EbfC DNA-binding family

precursor_groups_83681

702.33 +- 200.67

0.01 +- 0.00

TIGR00556 (2/2) phosphopantetheine--protein transferase domain
TIGR00027 (2/2) methyltransferase, TIGR00027 family
PF12706 (2/2) Beta-lactamase superfamily domain
PF11583 (2/2) P-aminobenzoate N-oxygenase AurF
PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180)
PF07690 (2/2) Major Facilitator Superfamily
PF06628 (2/2) Catalase-related immune-responsive
PF04072 (2/2) Leucine carboxyl methyltransferase
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (2/2) MaoC like domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00199 (2/2) Catalase

precursor_groups_56850

146.32 +- 79.43

0.04 +- 0.06

TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (2/2) putative ATP-grasp target RiPP
TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
PF07702 (2/2) UTRA domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_6965

216.00 +- 44.00

0.03 +- 0.04

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_groups_9048

119.08 +- 0.00

0.03 +- 0.01

TIGR03930 (2/2) WXG100 family type VII secretion target
TIGR03921 (2/2) type VII secretion-associated serine protease mycosin
TIGR03919 (2/2) type VII secretion protein EccB
PF06013 (2/2) Proteins of 100 residues with WXG
PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B
PF00082 (2/2) Subtilase family

precursor_groups_46472

300.06 +- 213.54

0.04 +- 0.05

PF17900 (3/3) Peptidase M1 N-terminal domain
PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain
PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (3/3) DJ-1/PfpI family
PF01433 (3/3) Peptidase family M1 domain
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00082 (3/3) Subtilase family

precursor_groups_2839

56.37 +- 16.27

0.08 +- 0.07

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF07690 (3/3) Major Facilitator Superfamily
PF00296 (3/3) Luciferase-like monooxygenase
PF00106 (3/3) short chain dehydrogenase

precursor_groups_10786

234.57 +- 34.56

0.01 +- 0.00

PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03713 (3/3) Domain of unknown function (DUF305)
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain

precursor_groups_72732

461.05 +- 11.67

0.04 +- 0.01

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02774 (2/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (2/2) Amino acid kinase family
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain

precursor_groups_3163

322.50 +- 64.50

0.01 +- 0.00

PF17964 (1/2) Bacterial Ig domain
PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF04672 (1/2) S-adenosyl methyltransferase
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_2844

37.67 +- 9.91

0.06 +- 0.08

PF17866 (8/8) AAA lid domain
PF13229 (8/8) Right handed beta helix region
PF00652 (8/8) Ricin-type beta-trefoil lectin domain
PF00082 (8/8) Subtilase family
PF00004 (8/8) ATPase family associated with various cellular activities (AAA)

precursor_groups_50774

1057.64 +- 490.36

0.01 +- 0.02

TIGR04353 (2/2) PqqD family protein, HPr-rel-A system
PF13646 (2/2) HEAT repeats
PF13471 (2/2) Transglutaminase-like superfamily
PF13411 (2/2) MerR HTH family regulatory protein
PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (2/2) Asparagine synthase
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_77287

476.67 +- 43.33

0.01 +- 0.00

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_19328

388.80 +- 1.47

0.01 +- 0.00

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)

precursor_groups_1879

104.64 +- 38.90

0.06 +- 0.07

PF14158 (15/15) YndJ-like protein
PF13581 (15/15) Histidine kinase-like ATPase domain
PF13492 (15/15) GAF domain
PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (15/15) Domain of unknown function (DUF1990)
PF08447 (15/15) PAS fold
PF07228 (15/15) Stage II sporulation protein E (SpoIIE)
PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00149 (15/15) Calcineurin-like phosphoesterase

precursor_groups_47870

249.70 +- 143.29

0.05 +- 0.05

TIGR03425 (3/3) urea carboxylase-associated protein 2
TIGR03424 (3/3) urea carboxylase-associated protein 1
TIGR02712 (3/3) urea carboxylase
TIGR01930 (3/3) acetyl-CoA C-acyltransferase
TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13520 (3/3) Amino acid permease
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF09347 (3/3) Domain of unknown function (DUF1989)
PF02803 (3/3) Thiolase, C-terminal domain
PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (3/3) Biotin carboxylase C-terminal domain
PF02682 (3/3) Carboxyltransferase domain, subdomain C and D
PF02626 (3/3) Carboxyltransferase domain, subdomain A and B
PF01425 (3/3) Amidase
PF00440 (3/3) Bacterial regulatory proteins, tetR family
PF00364 (3/3) Biotin-requiring enzyme
PF00289 (3/3) Biotin carboxylase, N-terminal domain
PF00108 (3/3) Thiolase, N-terminal domain

precursor_groups_44302

260.13 +- 5.78

0.02 +- 0.01

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
TIGR00326 (2/2) riboflavin biosynthesis protein RibD
PF13641 (2/2) Glycosyltransferase like family 2
PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain
PF07690 (2/2) Major Facilitator Superfamily
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01872 (2/2) RibD C-terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00400 (2/2) WD domain, G-beta repeat
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region

precursor_groups_40334

1659.14 +- 53.80

0.01 +- 0.01

PF13622 (2/2) Thioesterase-like superfamily
PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00487 (2/2) Fatty acid desaturase
PF00326 (2/2) Prolyl oligopeptidase family
PF00301 (2/2) Rubredoxin
PF00067 (2/2) Cytochrome P450
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family

precursor_groups_1690

929.57 +- 1135.98

0.04 +- 0.11

PF03412 (27/28) Peptidase C39 family
PF00664 (27/28) ABC transporter transmembrane region
PF00005 (27/28) ABC transporter
TIGR03897 (26/28) type 2 lantibiotic biosynthesis protein LanM
PF13575 (26/28) Domain of unknown function (DUF4135)
PF05147 (26/28) Lanthionine synthetase C-like protein
PF14867 (23/28) Lantibiotic alpha
PF00296 (19/28) Luciferase-like monooxygenase

precursor_groups_13078

1151.39 +- 1025.31

0.05 +- 0.17

PF03176 (5/5) MMPL family
PF00550 (5/5) Phosphopantetheine attachment site
PF00202 (5/5) Aminotransferase class-III
TIGR03605 (4/5) SagB-type dehydrogenase domain
TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/5) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/5) Methyltransferase domain
PF07993 (4/5) Male sterility protein
PF03364 (4/5) Polyketide cyclase / dehydrase and lipid transport
PF02801 (4/5) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/5) Nitroreductase family
PF00698 (4/5) Acyl transferase domain
PF00196 (4/5) Bacterial regulatory proteins, luxR family
PF00109 (4/5) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/5) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/5) MOSC domain
PF01575 (3/5) MaoC like domain
PF00675 (3/5) Insulinase (Peptidase family M16)

precursor_groups_69987

895.44 +- 308.77

0.02 +- 0.03

precursor_groups_19730

24.99 +- 2.38

0.08 +- 0.07

PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00457 (2/2) Glycosyl hydrolases family 11
PF00331 (2/2) Glycosyl hydrolase family 10

precursor_groups_7741

338.07 +- 45.25

0.09 +- 0.24

TIGR01902 (7/7) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (7/7) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (7/7) alpha-L-glutamate ligase, RimK family
PF18603 (7/7) L-amino acid ligase C-terminal domain 2
PF18130 (7/7) ATP-grasp N-terminal domain
PF13535 (7/7) ATP-grasp domain
PF08443 (7/7) RimK-like ATP-grasp domain
PF07690 (7/7) Major Facilitator Superfamily
PF02779 (7/7) Transketolase, pyrimidine binding domain
PF01546 (7/7) Peptidase family M20/M25/M40
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (7/7) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (7/7) Amino acid kinase family
PF00456 (7/7) Transketolase, thiamine diphosphate binding domain
PF00664 (6/7) ABC transporter transmembrane region
PF00005 (6/7) ABC transporter
PF13560 (5/7) Helix-turn-helix domain
PF10901 (5/7) Protein of unknown function (DUF2690)
PF01471 (5/7) Putative peptidoglycan binding domain

precursor_groups_32566

97.43 +- 4.08

0.02 +- 0.02

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)

precursor_groups_563

355.50 +- 160.50

0.03 +- 0.03

PF05147 (4/4) Lanthionine synthetase C-like protein
PF01061 (4/4) ABC-2 type transporter
PF00069 (4/4) Protein kinase domain
PF00005 (4/4) ABC transporter
TIGR01188 (2/4) daunorubicin resistance ABC transporter, ATP-binding protein

precursor_groups_566

491.70 +- 429.24

0.02 +- 0.05

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
TIGR00879 (5/5) MFS transporter, sugar porter (SP) family
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF05199 (5/5) GMC oxidoreductase
PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold
PF00732 (5/5) GMC oxidoreductase
PF00682 (5/5) HMGL-like
PF00293 (5/5) NUDIX domain
PF00083 (5/5) Sugar (and other) transporter
PF01761 (4/5) 3-dehydroquinate synthase

precursor_groups_568

387.98 +- 101.27

0.06 +- 0.09

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter
PF01965 (2/3) DJ-1/PfpI family

precursor_groups_569

288.11 +- 28.11

0.03 +- 0.03

TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13471 (1/2) Transglutaminase-like superfamily
PF04235 (1/2) Protein of unknown function (DUF418)
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00005 (1/2) ABC transporter

precursor_groups_24085

125.56 +- 76.73

0.02 +- 0.01

TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10977 (4/4) Protein of unknown function (DUF2797)
PF07398 (4/4) MDMPI C-terminal domain

precursor_groups_80972

2399.40 +- 696.60

0.01 +- 0.00

PF17914 (2/2) HopA1 effector protein family
PF09335 (2/2) SNARE associated Golgi protein
PF05193 (2/2) Peptidase M16 inactive domain
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00891 (2/2) O-methyltransferase domain
PF00675 (2/2) Insulinase (Peptidase family M16)
PF00664 (2/2) ABC transporter transmembrane region
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_64989

183.91 +- 13.29

0.08 +- 0.06

PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (2/2) Alpha galactosidase A
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

precursor_groups_4804

196.89 +- 6.51

0.04 +- 0.15

precursor_groups_83901

142.22 +- 29.78

0.06 +- 0.03

PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain
PF07690 (2/2) Major Facilitator Superfamily
PF03466 (2/2) LysR substrate binding domain
PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00754 (2/2) F5/8 type C domain
PF00703 (2/2) Glycosyl hydrolases family 2
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_30428

332.84 +- 267.53

0.06 +- 0.12

TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II
PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF08501 (3/3) Shikimate dehydrogenase substrate binding domain
PF07836 (3/3) DmpG-like communication domain
PF07690 (3/3) Major Facilitator Superfamily
PF02627 (3/3) Carboxymuconolactone decarboxylase family
PF01614 (3/3) Bacterial transcriptional regulator
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF01261 (3/3) Xylose isomerase-like TIM barrel
PF01220 (3/3) Dehydroquinase class II
PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00682 (3/3) HMGL-like
PF00083 (3/3) Sugar (and other) transporter
TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating)
PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain

precursor_groups_27291

186.44 +- 101.19

0.02 +- 0.02

PF16353 (3/3) Domain of unknown function(DUF4981)
PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF02929 (3/3) Beta galactosidase small chain
PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (3/3) Glycosyl hydrolases family 2

precursor_groups_69979

64.13 +- 5.87

0.06 +- 0.13

TIGR00753 (2/2) undecaprenyl-diphosphatase UppP
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12840 (2/2) Helix-turn-helix domain
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF03088 (2/2) Strictosidine synthase
PF02673 (2/2) Bacitracin resistance protein BacA

precursor_groups_9908

131.54 +- 3.07

0.09 +- 0.06

precursor_groups_75287

971.25 +- 3.75

0.01 +- 0.00

precursor_groups_10458

320.07 +- 19.07

0.05 +- 0.02

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF12697 (2/2) Alpha/beta hydrolase family
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (2/2) Amidohydrolase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (2/2) Coenzyme A transferase
PF00501 (2/2) AMP-binding enzyme
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (2/2) short chain dehydrogenase
PF00005 (2/2) ABC transporter
PF01965 (1/2) DJ-1/PfpI family

precursor_groups_86395

777.00 +- 3.00

0.01 +- 0.00

PF14759 (2/2) Reductase C-terminal
PF13279 (2/2) Thioesterase-like superfamily
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (2/2) Flavin reductase like domain
PF00775 (2/2) Dioxygenase
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00067 (2/2) Cytochrome P450

precursor_groups_24883

73.19 +- 11.76

0.08 +- 0.08

TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC
PF13560 (2/2) Helix-turn-helix domain
PF13478 (2/2) XdhC Rossmann domain
PF13367 (2/2) PrsW family intramembrane metalloprotease
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (2/2) XdhC and CoxI family
PF01799 (2/2) [2Fe-2S] binding domain
PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase
PF00756 (2/2) Putative esterase
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_10171

369.78 +- 5.91

0.07 +- 0.20

TIGR03177 (3/3) Flp pilus assembly protein CpaB
PF16976 (3/3) Flp pilus assembly protein RcpC/CpaB
PF15648 (3/3) Restriction endonuclease fold toxin 5
PF13614 (3/3) AAA domain
PF13400 (3/3) Putative Flp pilus-assembly TadE/G-like
PF13231 (3/3) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07811 (3/3) TadE-like protein
PF07730 (3/3) Histidine kinase
PF00691 (3/3) OmpA family
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00482 (3/3) Type II secretion system (T2SS), protein F
PF00437 (3/3) Type II/IV secretion system protein
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF00005 (3/3) ABC transporter

precursor_groups_81753

1942.50 +- 7.50

0.01 +- 0.00

TIGR01891 (2/2) amidohydrolase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00004 (2/2) reactive intermediate/imine deaminase
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05299 (2/2) M61 glycyl aminopeptidase
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00266 (2/2) Aminotransferase class-V
PF00005 (2/2) ABC transporter

precursor_groups_15593

303.16 +- 34.84

0.06 +- 0.10

TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily
PF14310 (2/2) Fibronectin type III-like domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (2/2) Peptidase_C39 like family
PF12697 (2/2) Alpha/beta hydrolase family
PF07729 (2/2) FCD domain
PF06684 (2/2) Amino acid synthesis
PF04545 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04539 (2/2) Sigma-70 region 3
PF03547 (2/2) Membrane transport protein
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00296 (2/2) Luciferase-like monooxygenase
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_10071

935.22 +- 296.60

0.01 +- 0.00

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (9/9) CPBP intramembrane metalloprotease
PF00881 (9/9) Nitroreductase family
PF00296 (9/9) Luciferase-like monooxygenase

precursor_groups_73123

777.00 +- 3.00

0.01 +- 0.00

PF09339 (2/2) IclR helix-turn-helix domain
PF07690 (2/2) Major Facilitator Superfamily
PF01614 (2/2) Bacterial transcriptional regulator
PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00557 (2/2) Metallopeptidase family M24
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00171 (2/2) Aldehyde dehydrogenase family

precursor_groups_30634

179.53 +- 21.38

0.08 +- 0.15

PF13641 (2/2) Glycosyltransferase like family 2
PF10823 (2/2) Protein of unknown function (DUF2568)
PF09335 (2/2) SNARE associated Golgi protein
PF07690 (2/2) Major Facilitator Superfamily
PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (2/2) LysE type translocator
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (2/2) GTP cyclohydrolase II
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00400 (2/2) WD domain, G-beta repeat
PF00067 (2/2) Cytochrome P450

precursor_groups_1298

137.11 +- 11.03

0.03 +- 0.04

PF13471 (4/4) Transglutaminase-like superfamily
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF00733 (4/4) Asparagine synthase

precursor_groups_1110

1141.85 +- 566.92

0.02 +- 0.02

PF13471 (11/11) Transglutaminase-like superfamily
PF05402 (11/11) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (11/11) Asparagine synthase
PF00005 (9/11) ABC transporter

precursor_groups_740

69.46 +- 4.96

0.04 +- 0.04

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF12802 (1/2) MarR family

precursor_groups_1501

323.00 +- 111.43

0.01 +- 0.00

TIGR04276 (4/4) FxsC C-terminal domain
TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (4/4) HEXXH motif domain
PF13676 (4/4) TIR domain
PF13424 (4/4) Tetratricopeptide repeat
PF13374 (4/4) Tetratricopeptide repeat
PF04055 (4/4) Radical SAM superfamily
PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (4/4) NB-ARC domain
TIGR04268 (2/4) FXSXX-COOH protein

precursor_groups_44971

738.11 +- 238.15

0.01 +- 0.01

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13394 (3/3) 4Fe-4S single cluster domain
PF07690 (3/3) Major Facilitator Superfamily
PF06508 (3/3) Queuosine biosynthesis protein QueC
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02310 (3/3) B12 binding domain
PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase
PF01227 (3/3) GTP cyclohydrolase I
PF00668 (3/3) Condensation domain
PF00501 (3/3) AMP-binding enzyme
PF00487 (3/3) Fatty acid desaturase

precursor_groups_1057

247.62 +- 143.54

0.02 +- 0.03

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (5/6) Lantibiotic dehydratase, N terminus

precursor_groups_35030

215.00 +- 60.81

0.01 +- 0.01

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase

precursor_groups_18349

782.11 +- 340.79

0.01 +- 0.01

TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain
TIGR01420 (6/6) twitching motility protein
PF07963 (6/6) Prokaryotic N-terminal methylation motif
PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF00437 (6/6) Type II/IV secretion system protein

precursor_groups_72835

462.83 +- 311.17

0.02 +- 0.04

PF03704 (2/2) Bacterial transcriptional activator domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01546 (2/2) Peptidase family M20/M25/M40
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00486 (2/2) Transcriptional regulatory protein, C terminal

precursor_groups_45577

533.02 +- 31.35

0.01 +- 0.00

TIGR01891 (2/2) amidohydrolase
PF14518 (2/2) Iron-containing redox enzyme
PF07690 (2/2) Major Facilitator Superfamily
PF04204 (2/2) Homoserine O-succinyltransferase
PF03704 (2/2) Bacterial transcriptional activator domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (2/2) NB-ARC domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal

precursor_groups_1592

252.97 +- 169.22

0.03 +- 0.07

PF07291 (9/9) Methylamine utilisation protein MauE
PF00717 (9/9) Peptidase S24-like
PF00005 (9/9) ABC transporter
PF10502 (6/9) Signal peptidase, peptidase S26
PF00578 (6/9) AhpC/TSA family

precursor_groups_42755

100.33 +- 20.27

0.02 +- 0.02

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme

precursor_groups_14774

63.45 +- 1.05

0.06 +- 0.06

PF08220 (2/2) DeoR-like helix-turn-helix domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00455 (2/2) DeoR C terminal sensor domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_77109

21.30 +- 0.66

0.09 +- 0.13

TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit
PF07077 (2/2) Protein of unknown function (DUF1345)
PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00384 (2/2) Molybdopterin oxidoreductase

precursor_groups_7824

134.38 +- 26.88

0.02 +- 0.01

PF13515 (2/2) Fusaric acid resistance protein-like
PF08386 (2/2) TAP-like protein
PF01471 (2/2) Putative peptidoglycan binding domain
PF00561 (2/2) alpha/beta hydrolase fold
PF00931 (1/2) NB-ARC domain

precursor_groups_5193

34.39 +- 12.89

0.09 +- 0.08

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator

precursor_groups_23

417.58 +- 443.50

0.02 +- 0.05

PF03965 (2/3) Penicillinase repressor
PF01435 (2/3) Peptidase family M48
PF00403 (2/3) Heavy-metal-associated domain

precursor_groups_26

338.56 +- 113.59

0.09 +- 0.18

PF03412 (5/5) Peptidase C39 family
PF00664 (5/5) ABC transporter transmembrane region
PF00005 (5/5) ABC transporter
TIGR03797 (4/5) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (4/5) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13437 (4/5) HlyD family secretion protein
PF10604 (3/5) Polyketide cyclase / dehydrase and lipid transport
PF07690 (3/5) Major Facilitator Superfamily
PF05013 (3/5) N-formylglutamate amidohydrolase
PF03055 (3/5) Retinal pigment epithelial membrane protein
PF00440 (3/5) Bacterial regulatory proteins, tetR family

precursor_groups_3158

34.67 +- 0.00

0.09 +- 0.12

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF11361 (2/2) Protein of unknown function (DUF3159)
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01522 (2/2) Polysaccharide deacetylase

precursor_groups_16507

593.52 +- 220.55

0.02 +- 0.04

TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF08007 (6/6) Cupin superfamily protein
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF00664 (6/6) ABC transporter transmembrane region
PF00005 (6/6) ABC transporter
TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit
PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase

precursor_groups_3156

174.09 +- 18.88

0.07 +- 0.09

precursor_groups_5697

196.34 +- 50.80

0.08 +- 0.07

TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (5/5) hydrolase CocE/NonD family protein
PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family)
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
PF00583 (5/5) Acetyltransferase (GNAT) family
PF00528 (5/5) Binding-protein-dependent transport system inner membrane component
PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3
PF00005 (5/5) ABC transporter
PF00296 (3/5) Luciferase-like monooxygenase

precursor_groups_59389

61.28 +- 3.22

0.05 +- 0.03

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme

precursor_groups_345

885.57 +- 176.07

0.01 +- 0.01

TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily
PF07690 (4/4) Major Facilitator Superfamily
PF03737 (4/4) Aldolase/RraA
PF03466 (4/4) LysR substrate binding domain
PF01361 (4/4) Tautomerase enzyme
PF00994 (4/4) Probable molybdopterin binding domain
PF00682 (4/4) HMGL-like
PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase
PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_groups_68668

38.91 +- 7.53

0.08 +- 0.05

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_groups_22163

437.99 +- 138.99

0.02 +- 0.10

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01543 (2/2) phage prohead protease, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF05065 (2/2) Phage capsid family
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
TIGR00621 (1/2) single-stranded DNA-binding protein
PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein
PF13385 (1/2) Concanavalin A-like lectin/glucanases superfamily
PF12708 (1/2) Pectate lyase superfamily protein
PF12307 (1/2) Protein of unknown function (DUF3631)
PF09250 (1/2) Bifunctional DNA primase/polymerase, N-terminal
PF05709 (1/2) Phage tail protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain

precursor_groups_76120

103.09 +- 21.09

0.06 +- 0.08

TIGR01496 (2/2) dihydropteroate synthase
PF08310 (2/2) LGFP repeat
PF07995 (2/2) Glucose / Sorbosone dehydrogenase
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00809 (2/2) Pterin binding enzyme
PF00801 (2/2) PKD domain
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme

precursor_groups_35953

121.07 +- 15.52

0.03 +- 0.05

TIGR01297 (2/2) cation diffusion facilitator family transporter
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (2/2) IstB-like ATP binding protein
PF01545 (2/2) Cation efflux family
PF00665 (2/2) Integrase core domain
PF00501 (2/2) AMP-binding enzyme
PF00221 (2/2) Aromatic amino acid lyase

precursor_groups_41968

1855.31 +- 282.62

0.04 +- 0.15

precursor_groups_64500

100.71 +- 10.71

0.06 +- 0.04

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_16430

409.86 +- 183.82

0.02 +- 0.01

PF13450 (5/5) NAD(P)-binding Rossmann-like domain
PF07690 (5/5) Major Facilitator Superfamily
PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00743 (5/5) Flavin-binding monooxygenase-like
PF00348 (5/5) Polyprenyl synthetase
PF00106 (5/5) short chain dehydrogenase
TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

precursor_groups_78567

50.96 +- 10.96

0.06 +- 0.07

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

precursor_groups_63631

53.39 +- 20.89

0.05 +- 0.04

PF13602 (2/2) Zinc-binding dehydrogenase
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00106 (2/2) short chain dehydrogenase
PF13564 (1/2) DoxX-like family
PF00296 (1/2) Luciferase-like monooxygenase

precursor_groups_12692

968.17 +- 676.53

0.07 +- 0.11

TIGR01746 (5/5) thioester reductase domain
TIGR01733 (5/5) amino acid adenylation domain
TIGR01525 (5/5) heavy metal translocating P-type ATPase
TIGR00747 (5/5) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF10862 (5/5) FcoT-like thioesterase domain
PF08545 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (5/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (5/5) Male sterility protein
PF07690 (5/5) Major Facilitator Superfamily
PF05118 (5/5) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (5/5) Copper chaperone PCu(A)C
PF03929 (5/5) PepSY-associated TM region
PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (5/5) DJ-1/PfpI family
PF01794 (5/5) Ferric reductase like transmembrane component
PF01497 (5/5) Periplasmic binding protein
PF01032 (5/5) FecCD transport family
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00668 (5/5) Condensation domain
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00403 (5/5) Heavy-metal-associated domain
PF00122 (5/5) E1-E2 ATPase
PF00005 (5/5) ABC transporter
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
PF08281 (4/5) Sigma-70, region 4
PF04542 (4/5) Sigma-70 region 2

precursor_groups_22188

43.48 +- 8.68

0.07 +- 0.05

PF13478 (3/3) XdhC Rossmann domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (3/3) XdhC and CoxI family
PF01799 (3/3) [2Fe-2S] binding domain
PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase
PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain

precursor_groups_71012

194.00 +- 64.00

0.01 +- 0.01

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain

precursor_groups_119

75.88 +- 0.00

0.07 +- 0.07

TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (2/2) pyruvate, phosphate dikinase
TIGR01255 (2/2) formate acetyltransferase
PF14325 (2/2) Domain of unknown function (DUF4383)
PF13411 (2/2) MerR HTH family regulatory protein
PF04055 (2/2) Radical SAM superfamily
PF02901 (2/2) Pyruvate formate lyase-like
PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (2/2) B12 binding domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (2/2) Glycine radical
PF00582 (2/2) Universal stress protein family
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00106 (2/2) short chain dehydrogenase

precursor_groups_6108

87.16 +- 4.60

0.09 +- 0.18

TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF01292 (2/2) Prokaryotic cytochrome b561
PF00296 (2/2) Luciferase-like monooxygenase
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00188 (2/2) Cysteine-rich secretory protein family
PF00174 (2/2) Oxidoreductase molybdopterin binding domain
PF00072 (2/2) Response regulator receiver domain
PF00005 (2/2) ABC transporter

precursor_groups_11480

324.25 +- 46.50

0.01 +- 0.00

TIGR01746 (3/3) thioester reductase domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07993 (3/3) Male sterility protein
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00196 (3/3) Bacterial regulatory proteins, luxR family

precursor_groups_446

1399.85 +- 1431.38

0.02 +- 0.05

PF17914 (62/62) HopA1 effector protein family
PF02441 (61/62) Flavoprotein
PF00675 (61/62) Insulinase (Peptidase family M16)
PF05193 (59/62) Peptidase M16 inactive domain
PF00296 (57/62) Luciferase-like monooxygenase
PF00005 (55/62) ABC transporter
PF00664 (35/62) ABC transporter transmembrane region
PF13649 (33/62) Methyltransferase domain

precursor_groups_14492

164.69 +- 103.36

0.05 +- 0.04

TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating)
PF13621 (7/7) Cupin-like domain
PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (7/7) DmpG-like communication domain
PF07690 (7/7) Major Facilitator Superfamily
PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family
PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (7/7) HMGL-like
PF00155 (7/7) Aminotransferase class I and II

precursor_groups_39806

205.89 +- 16.36

0.06 +- 0.11

TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (2/2) Domain of unknown function (DUF4380)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13407 (2/2) Periplasmic binding protein domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (2/2) Branched-chain amino acid transport system / permease component
PF01081 (2/2) KDPG and KHG aldolase
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter

precursor_groups_22265

237.00 +- 29.70

0.01 +- 0.00

TIGR01733 (3/3) amino acid adenylation domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF12680 (3/3) SnoaL-like domain
PF08242 (3/3) Methyltransferase domain
PF07883 (3/3) Cupin domain
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme

precursor_groups_16466

273.59 +- 115.10

0.03 +- 0.01

PF07690 (6/6) Major Facilitator Superfamily
PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region
PF02538 (6/6) Hydantoinase B/oxoprolinase
PF01968 (6/6) Hydantoinase/oxoprolinase
PF01380 (6/6) SIS domain
PF01019 (6/6) Gamma-glutamyltranspeptidase
PF00294 (6/6) pfkB family carbohydrate kinase

precursor_groups_16970

592.86 +- 404.30

0.05 +- 0.08

PF13411 (3/3) MerR HTH family regulatory protein
PF07739 (3/3) TipAS antibiotic-recognition domain
PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF01551 (3/3) Peptidase family M23
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
PF12679 (2/3) ABC-2 family transporter protein

precursor_groups_41831

445.71 +- 74.29

0.01 +- 0.00

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF00676 (2/2) Dehydrogenase E1 component
PF00550 (2/2) Phosphopantetheine attachment site
PF00364 (2/2) Biotin-requiring enzyme
PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

precursor_groups_114

276.73 +- 93.81

0.06 +- 0.07

TIGR01234 (2/4) ribulokinase
PF18029 (2/4) Glyoxalase-like domain
PF14200 (2/4) Ricin-type beta-trefoil lectin domain-like
PF11762 (2/4) L-arabinose isomerase C-terminal domain
PF07690 (2/4) Major Facilitator Superfamily
PF06964 (2/4) Alpha-L-arabinofuranosidase C-terminal domain
PF06772 (2/4) Bacterial low temperature requirement A protein (LtrA)
PF02782 (2/4) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/4) L-arabinose isomerase
PF01547 (2/4) Bacterial extracellular solute-binding protein
PF00596 (2/4) Class II Aldolase and Adducin N-terminal domain
PF00561 (2/4) alpha/beta hydrolase fold
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
PF00370 (2/4) FGGY family of carbohydrate kinases, N-terminal domain
PF00296 (2/4) Luciferase-like monooxygenase
PF00106 (2/4) short chain dehydrogenase

precursor_groups_77189

362.00 +- 154.00

0.01 +- 0.01

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

precursor_groups_47289

358.87 +- 76.47

0.03 +- 0.03

TIGR03396 (3/3) phospholipase C, phosphocholine-specific
TIGR01258 (3/3) phosphoglycerate mutase 1 family
TIGR01060 (3/3) phosphopyruvate hydratase
PF11575 (3/3) FhuF 2Fe-2S C-terminal domain
PF07228 (3/3) Stage II sporulation protein E (SpoIIE)
PF05506 (3/3) Domain of unknown function (DUF756)
PF04185 (3/3) Phosphoesterase family
PF03965 (3/3) Penicillinase repressor
PF03952 (3/3) Enolase, N-terminal domain
PF03453 (3/3) MoeA N-terminal region (domain I and II)
PF01712 (3/3) Deoxynucleoside kinase
PF01435 (3/3) Peptidase family M48
PF00994 (3/3) Probable molybdopterin binding domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00293 (3/3) NUDIX domain
PF00113 (3/3) Enolase, C-terminal TIM barrel domain

precursor_groups_64817

3194.97 +- 210.63

0.02 +- 0.01

precursor_groups_23209

51.32 +- 24.99

0.05 +- 0.06

PF13424 (3/3) Tetratricopeptide repeat
PF07719 (3/3) Tetratricopeptide repeat
PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif
PF03413 (3/3) Peptidase propeptide and YPEB domain
PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
PF00348 (3/3) Polyprenyl synthetase

precursor_groups_48894

118.75 +- 11.25

0.08 +- 0.11

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (2/2) NMT1/THI5 like
PF05719 (2/2) Golgi phosphoprotein 3 (GPP34)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter

precursor_groups_27600

144.98 +- 11.02

0.09 +- 0.06

PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (2/2) Enolase C-terminal domain-like
PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (2/2) FCD domain
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (2/2) Melibiase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF01081 (2/2) KDPG and KHG aldolase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF00294 (2/2) pfkB family carbohydrate kinase
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A

precursor_groups_15312

166.79 +- 16.68

0.05 +- 0.06

PF17137 (2/2) Domain of unknown function (DUF5110)
PF16338 (2/2) Domain of unknown function (DUF4968)
PF13520 (2/2) Amino acid permease
PF07730 (2/2) Histidine kinase
PF03466 (2/2) LysR substrate binding domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (2/2) Response regulator receiver domain
PF00069 (2/2) Protein kinase domain

precursor_groups_15314

161.25 +- 96.75

0.02 +- 0.03

TIGR01840 (2/2) esterase, PHB depolymerase family
TIGR00666 (2/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (2/2) Protein of unknown function (DUF4232)
PF10503 (2/2) Esterase PHB depolymerase
PF02113 (2/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family

precursor_groups_67526

414.64 +- 27.64

0.01 +- 0.00

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00884 (2/2) Sulfatase

precursor_groups_8062

444.94 +- 356.18

0.03 +- 0.04

precursor_groups_22919

502.26 +- 347.48

0.05 +- 0.18

TIGR01509 (5/5) HAD hydrolase, family IA, variant 3
PF13419 (5/5) Haloacid dehalogenase-like hydrolase
PF13191 (5/5) AAA ATPase domain
PF12710 (5/5) haloacid dehalogenase-like hydrolase
PF07690 (5/5) Major Facilitator Superfamily
PF04321 (5/5) RmlD substrate binding domain
PF01979 (5/5) Amidohydrolase family
PF00535 (5/5) Glycosyl transferase family 2
PF00480 (5/5) ROK family
PF00459 (5/5) Inositol monophosphatase family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00202 (5/5) Aminotransferase class-III
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF13632 (4/5) Glycosyl transferase family group 2
TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent
PF03971 (3/5) Monomeric isocitrate dehydrogenase
PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_groups_624

260.57 +- 94.71

0.04 +- 0.05

PF12770 (2/2) CHAT domain
PF17866 (1/2) AAA lid domain
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF13229 (1/2) Right handed beta helix region
PF03756 (1/2) A-factor biosynthesis hotdog domain
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00082 (1/2) Subtilase family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

precursor_groups_4272

23.45 +- 0.00

0.09 +- 0.07

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/2) Methyltransferase domain
PF00753 (2/2) Metallo-beta-lactamase superfamily

precursor_groups_1627

148.42 +- 88.47

0.03 +- 0.02

PF13649 (10/10) Methyltransferase domain
PF07690 (10/10) Major Facilitator Superfamily
PF04055 (10/10) Radical SAM superfamily

precursor_groups_62305

766.32 +- 13.68

0.01 +- 0.00

TIGR01490 (2/2) HAD hydrolase, family IB
PF12710 (2/2) haloacid dehalogenase-like hydrolase
PF07690 (2/2) Major Facilitator Superfamily
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01494 (2/2) FAD binding domain
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF00975 (2/2) Thioesterase domain
PF00891 (2/2) O-methyltransferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00248 (2/2) Aldo/keto reductase family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain

precursor_groups_1150

366.81 +- 92.54

0.07 +- 0.08

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF13191 (7/7) AAA ATPase domain
PF04738 (7/7) Lantibiotic dehydratase, N terminus
PF03704 (7/7) Bacterial transcriptional activator domain
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (7/7) ABC-2 type transporter
PF00881 (7/7) Nitroreductase family
PF00486 (7/7) Transcriptional regulatory protein, C terminal
PF00005 (7/7) ABC transporter

precursor_groups_79452

372.32 +- 128.18

0.03 +- 0.03

TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (2/2) Periplasmic binding protein-like domain
PF12833 (2/2) Helix-turn-helix domain
PF02065 (2/2) Melibiase
PF01965 (2/2) DJ-1/PfpI family
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_groups_37210

154.25 +- 11.20

0.05 +- 0.16

TIGR03026 (2/2) nucleotide sugar dehydrogenase
TIGR01733 (2/2) amino acid adenylation domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13469 (2/2) Sulfotransferase family
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (2/2) Malate/L-lactate dehydrogenase
PF01522 (2/2) Polysaccharide deacetylase
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00196 (2/2) Bacterial regulatory proteins, luxR family

precursor_groups_19241

148.40 +- 67.91

0.02 +- 0.02

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold

precursor_groups_23731

734.34 +- 335.62

0.06 +- 0.06

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (4/4) thioester reductase domain
TIGR01733 (4/4) amino acid adenylation domain
TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR00747 (4/4) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF10862 (4/4) FcoT-like thioesterase domain
PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (4/4) Sigma-70, region 4
PF07993 (4/4) Male sterility protein
PF07690 (4/4) Major Facilitator Superfamily
PF05118 (4/4) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (4/4) Sigma-70 region 2
PF04314 (4/4) Copper chaperone PCu(A)C
PF03929 (4/4) PepSY-associated TM region
PF02668 (4/4) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (4/4) DJ-1/PfpI family
PF01794 (4/4) Ferric reductase like transmembrane component
PF01497 (4/4) Periplasmic binding protein
PF01032 (4/4) FecCD transport family
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00668 (4/4) Condensation domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00403 (4/4) Heavy-metal-associated domain
PF00122 (4/4) E1-E2 ATPase
PF00005 (4/4) ABC transporter

precursor_groups_1023

516.00 +- 129.00

0.01 +- 0.00

PF13471 (2/2) Transglutaminase-like superfamily
PF00733 (2/2) Asparagine synthase
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00005 (1/2) ABC transporter

precursor_groups_1534

107.29 +- 28.50

0.04 +- 0.04

TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family
TIGR00229 (2/2) PAS domain S-box protein
PF08448 (2/2) PAS fold
PF08447 (2/2) PAS fold
PF08386 (2/2) TAP-like protein
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00069 (2/2) Protein kinase domain

precursor_groups_1431

46.64 +- 3.06

0.06 +- 0.07

PF07730 (3/3) Histidine kinase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF13649 (2/3) Methyltransferase domain

precursor_groups_17315

116.33 +- 25.07

0.04 +- 0.04

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

precursor_groups_21458

137.60 +- 68.80

0.06 +- 0.05

precursor_groups_43861

396.47 +- 171.88

0.01 +- 0.02

TIGR01549 (3/3) HAD hydrolase, family IA, variant 1
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF18130 (3/3) ATP-grasp N-terminal domain
PF13535 (3/3) ATP-grasp domain
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF07690 (3/3) Major Facilitator Superfamily
PF06245 (3/3) Protein of unknown function (DUF1015)
PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain

precursor_groups_21455

303.45 +- 53.54

0.02 +- 0.01

PF17286 (3/3) PRMT5 oligomerisation domain
PF14518 (3/3) Iron-containing redox enzyme
PF13649 (3/3) Methyltransferase domain
PF07732 (3/3) Multicopper oxidase
PF01323 (3/3) DSBA-like thioredoxin domain
PF00701 (3/3) Dihydrodipicolinate synthetase family
PF00355 (3/3) Rieske [2Fe-2S] domain
PF00155 (3/3) Aminotransferase class I and II

precursor_groups_63

217.46 +- 123.66

0.04 +- 0.04

No common domains found

precursor_groups_63015

100.79 +- 5.13

0.06 +- 0.07

TIGR01891 (2/2) amidohydrolase
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13091 (2/2) PLD-like domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF06267 (2/2) Family of unknown function (DUF1028)
PF03466 (2/2) LysR substrate binding domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01042 (2/2) Endoribonuclease L-PSP
PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (2/2) Sugar (and other) transporter

precursor_groups_61

412.74 +- 203.81

0.06 +- 0.19

PF13400 (6/6) Putative Flp pilus-assembly TadE/G-like
PF00691 (6/6) OmpA family
PF00482 (6/6) Type II secretion system (T2SS), protein F
PF07730 (5/6) Histidine kinase
PF00196 (5/6) Bacterial regulatory proteins, luxR family
PF00072 (5/6) Response regulator receiver domain
TIGR03177 (4/6) Flp pilus assembly protein CpaB
PF16976 (4/6) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/6) AAA domain
PF07811 (4/6) TadE-like protein
PF00437 (4/6) Type II/IV secretion system protein
PF15648 (3/6) Restriction endonuclease fold toxin 5
PF13231 (3/6) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
PF00496 (3/6) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/6) ABC transporter

precursor_groups_13996

34.94 +- 12.33

0.07 +- 0.06

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF01872 (2/2) RibD C-terminal domain

precursor_groups_1870

187.80 +- 17.00

0.07 +- 0.08

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00005 (2/2) ABC transporter
TIGR03605 (1/2) SagB-type dehydrogenase domain
PF00931 (1/2) NB-ARC domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

precursor_groups_18839

142.22 +- 29.78

0.06 +- 0.03

precursor_groups_9334

94.90 +- 28.28

0.04 +- 0.02

PF12697 (4/4) Alpha/beta hydrolase family
PF07729 (4/4) FCD domain
PF06684 (4/4) Amino acid synthesis
PF00392 (4/4) Bacterial regulatory proteins, gntR family
PF00296 (4/4) Luciferase-like monooxygenase
PF00171 (4/4) Aldehyde dehydrogenase family

precursor_groups_30764

63.45 +- 1.05

0.06 +- 0.06

precursor_groups_42885

1018.46 +- 114.56

0.01 +- 0.00

PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily
PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily
PF07690 (3/3) Major Facilitator Superfamily
PF05193 (3/3) Peptidase M16 inactive domain
PF04055 (3/3) Radical SAM superfamily
PF00899 (3/3) ThiF family
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF02310 (2/3) B12 binding domain

precursor_groups_83319

132.91 +- 39.09

0.05 +- 0.09

PF13581 (2/2) Histidine kinase-like ATPase domain
PF07690 (2/2) Major Facilitator Superfamily
PF07681 (2/2) DoxX
PF02515 (2/2) CoA-transferase family III
PF01546 (2/2) Peptidase family M20/M25/M40
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (2/2) Enoyl-CoA hydratase/isomerase

precursor_groups_57593

1632.40 +- 187.60

0.01 +- 0.00

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_groups_18

1139.50 +- 368.96

0.03 +- 0.12

PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF01636 (2/3) Phosphotransferase enzyme family
PF00196 (2/3) Bacterial regulatory proteins, luxR family

precursor_groups_6879

358.32 +- 74.43

0.06 +- 0.03

PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase
PF08545 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain
PF01144 (10/10) Coenzyme A transferase
PF00378 (10/10) Enoyl-CoA hydratase/isomerase
PF00196 (10/10) Bacterial regulatory proteins, luxR family
PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain
PF00106 (10/10) short chain dehydrogenase
PF00005 (10/10) ABC transporter
TIGR00976 (9/10) hydrolase CocE/NonD family protein
PF13193 (9/10) AMP-binding enzyme C-terminal domain
PF12679 (9/10) ABC-2 family transporter protein
PF08530 (9/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (9/10) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (9/10) AMP-binding enzyme
PF04909 (8/10) Amidohydrolase
PF12697 (7/10) Alpha/beta hydrolase family

precursor_groups_4652

1090.53 +- 409.47

0.04 +- 0.03

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (2/2) Methyltransferase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01590 (2/2) GAF domain
PF01427 (2/2) D-ala-D-ala dipeptidase
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (2/2) Glycosyl hydrolases family 15
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF13671 (1/2) AAA domain
PF13378 (1/2) Enolase C-terminal domain-like
PF13242 (1/2) HAD-hyrolase-like
PF10103 (1/2) Zincin-like metallopeptidase
PF09364 (1/2) XFP N-terminal domain
PF09363 (1/2) XFP C-terminal domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF03894 (1/2) D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01300 (1/2) Telomere recombination

precursor_groups_17

441.98 +- 419.76

0.03 +- 0.06

PF13370 (13/19) 4Fe-4S single cluster domain of Ferredoxin I
PF00067 (10/19) Cytochrome P450

precursor_groups_1448

73.23 +- 29.66

0.05 +- 0.06

PF14534 (4/4) Domain of unknown function (DUF4440)
PF08002 (4/4) Protein of unknown function (DUF1697)
PF05922 (4/4) Peptidase inhibitor I9
PF00082 (4/4) Subtilase family
PF01323 (2/4) DSBA-like thioredoxin domain

precursor_groups_15

314.31 +- 204.63

0.06 +- 0.15

PF03621 (20/20) MbtH-like protein
PF00501 (19/20) AMP-binding enzyme
TIGR01733 (18/20) amino acid adenylation domain
PF13193 (18/20) AMP-binding enzyme C-terminal domain
PF00668 (18/20) Condensation domain
PF00550 (18/20) Phosphopantetheine attachment site
PF00975 (16/20) Thioesterase domain
TIGR01720 (13/20) non-ribosomal peptide synthase domain TIGR01720
TIGR03945 (11/20) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (11/20) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01188 (11/20) daunorubicin resistance ABC transporter, ATP-binding protein
PF02423 (11/20) Ornithine cyclodeaminase/mu-crystallin family
PF01061 (11/20) ABC-2 type transporter
PF00291 (11/20) Pyridoxal-phosphate dependent enzyme
PF00005 (11/20) ABC transporter

precursor_groups_3028

24.19 +- 0.00

0.08 +- 0.03

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme

precursor_groups_9053

226.50 +- 31.50

0.01 +- 0.00

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_groups_7584

511.36 +- 133.14

0.04 +- 0.17

PF17914 (5/5) HopA1 effector protein family
PF02441 (5/5) Flavoprotein
PF01636 (5/5) Phosphotransferase enzyme family
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (4/5) ABC transporter
PF02897 (3/5) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (3/5) Prolyl oligopeptidase family

precursor_groups_22780

960.29 +- 332.05

0.02 +- 0.01

PF13649 (5/5) Methyltransferase domain
PF12698 (5/5) ABC-2 family transporter protein
PF02441 (5/5) Flavoprotein
PF00005 (5/5) ABC transporter
PF17914 (4/5) HopA1 effector protein family
PF01636 (4/5) Phosphotransferase enzyme family
PF00664 (4/5) ABC transporter transmembrane region
PF13732 (3/5) Domain of unknown function (DUF4162)
PF00196 (3/5) Bacterial regulatory proteins, luxR family

precursor_groups_82316

889.37 +- 45.01

0.06 +- 0.17

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00802 (2/2) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (2/2) GYF domain 2
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13421 (2/2) SPFH domain-Band 7 family
PF08281 (2/2) Sigma-70, region 4
PF07690 (2/2) Major Facilitator Superfamily
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03824 (2/2) High-affinity nickel-transport protein
PF01070 (2/2) FMN-dependent dehydrogenase
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF00067 (2/2) Cytochrome P450
TIGR01733 (1/2) amino acid adenylation domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/2) Male sterility protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme

precursor_groups_68599

291.55 +- 224.45

0.03 +- 0.06

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_groups_150

243.84 +- 133.73

0.07 +- 0.08

TIGR00976 (4/4) hydrolase CocE/NonD family protein
PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family)
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF01497 (2/4) Periplasmic binding protein
PF01032 (2/4) FecCD transport family

precursor_groups_68754

381.16 +- 102.59

0.02 +- 0.02

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family

precursor_groups_12312

593.52 +- 220.55

0.02 +- 0.04

precursor_groups_16088

371.41 +- 284.77

0.03 +- 0.08

TIGR01060 (6/6) phosphopyruvate hydratase
PF18603 (6/6) L-amino acid ligase C-terminal domain 2
PF18130 (6/6) ATP-grasp N-terminal domain
PF16861 (6/6) Carbamoyltransferase C-terminus
PF14518 (6/6) Iron-containing redox enzyme
PF13535 (6/6) ATP-grasp domain
PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family
PF07690 (6/6) Major Facilitator Superfamily
PF06089 (6/6) L-asparaginase II
PF03952 (6/6) Enolase, N-terminal domain
PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02543 (6/6) Carbamoyltransferase N-terminus
PF00291 (6/6) Pyridoxal-phosphate dependent enzyme
PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain
PF00113 (6/6) Enolase, C-terminal TIM barrel domain

precursor_groups_21277

1463.93 +- 1117.75

0.02 +- 0.01

PF18603 (4/4) L-amino acid ligase C-terminal domain 2
PF18130 (4/4) ATP-grasp N-terminal domain
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF13535 (4/4) ATP-grasp domain
PF13378 (4/4) Enolase C-terminal domain-like
PF12146 (4/4) Serine aminopeptidase, S33
PF08241 (4/4) Methyltransferase domain
PF07690 (4/4) Major Facilitator Superfamily
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (4/4) GH3 auxin-responsive promoter
PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00694 (4/4) Aconitase C-terminal domain
PF00330 (4/4) Aconitase family (aconitate hydratase)

precursor_groups_78723

960.72 +- 458.28

0.02 +- 0.02

PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13191 (2/2) AAA ATPase domain
PF08659 (2/2) KR domain
PF04820 (2/2) Tryptophan halogenase
PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (2/2) Bacterial transcriptional activator domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01613 (2/2) Flavin reductase like domain
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00975 (2/2) Thioesterase domain
PF00931 (2/2) NB-ARC domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00107 (2/2) Zinc-binding dehydrogenase

precursor_groups_2140

108.35 +- 37.40

0.09 +- 0.06

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

precursor_groups_2388

699.99 +- 270.33

0.07 +- 0.19

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00802 (3/3) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (3/3) GYF domain 2
PF13421 (3/3) SPFH domain-Band 7 family
PF08281 (3/3) Sigma-70, region 4
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (3/3) Sigma-70 region 2
PF04314 (3/3) Copper chaperone PCu(A)C
PF03824 (3/3) High-affinity nickel-transport protein
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
TIGR01733 (2/3) amino acid adenylation domain
PF13738 (2/3) Pyridine nucleotide-disulphide oxidoreductase
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF10862 (2/3) FcoT-like thioesterase domain
PF08545 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (2/3) Male sterility protein
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01070 (2/3) FMN-dependent dehydrogenase
PF00668 (2/3) Condensation domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme
PF00067 (2/3) Cytochrome P450

precursor_groups_23252

68.37 +- 29.84

0.07 +- 0.06

TIGR00350 (3/3) cell envelope-related function transcriptional attenuator common domain
PF13399 (3/3) LytR cell envelope-related transcriptional attenuator
PF07859 (3/3) alpha/beta hydrolase fold
PF03816 (3/3) Cell envelope-related transcriptional attenuator domain
PF03807 (3/3) NADP oxidoreductase coenzyme F420-dependent
PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00459 (3/3) Inositol monophosphatase family

precursor_groups_36304

571.90 +- 331.10

0.02 +- 0.03

TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083
PF17964 (2/2) Bacterial Ig domain
PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (2/2) UTRA domain
PF07398 (2/2) MDMPI C-terminal domain
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF01381 (2/2) Helix-turn-helix
PF00931 (2/2) NB-ARC domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family

precursor_groups_574

693.83 +- 224.35

0.05 +- 0.16

TIGR04364 (3/3) methyltransferase, FxLD system
TIGR04363 (3/3) FxLD family lantipeptide
TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF01135 (3/3) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF13581 (2/3) Histidine kinase-like ATPase domain
PF05331 (2/3) Protein of unknown function (DUF742)
PF04851 (2/3) Type III restriction enzyme, res subunit
PF04672 (2/3) S-adenosyl methyltransferase
PF03457 (2/3) Helicase associated domain
PF03259 (2/3) Roadblock/LC7 domain
PF03029 (2/3) Conserved hypothetical ATP binding protein
PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF01636 (2/3) Phosphotransferase enzyme family
PF01590 (2/3) GAF domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/3) NUDIX domain
PF00271 (2/3) Helicase conserved C-terminal domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00005 (2/3) ABC transporter

precursor_groups_13665

156.96 +- 65.90

0.02 +- 0.03

PF07582 (2/2) AP endonuclease family 2 C terminus
PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel

precursor_groups_32252

379.18 +- 103.46

0.08 +- 0.09

TIGR01746 (3/3) thioester reductase domain
TIGR01733 (3/3) amino acid adenylation domain
TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (3/3) heavy metal translocating P-type ATPase
TIGR00747 (3/3) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF10862 (3/3) FcoT-like thioesterase domain
PF08545 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/3) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (3/3) Male sterility protein
PF07690 (3/3) Major Facilitator Superfamily
PF05118 (3/3) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (3/3) Copper chaperone PCu(A)C
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (3/3) DJ-1/PfpI family
PF01497 (3/3) Periplasmic binding protein
PF01032 (3/3) FecCD transport family
PF00702 (3/3) haloacid dehalogenase-like hydrolase
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00501 (3/3) AMP-binding enzyme
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (3/3) Heavy-metal-associated domain
PF00122 (3/3) E1-E2 ATPase
PF00005 (3/3) ABC transporter

precursor_groups_274

770.06 +- 659.94

0.03 +- 0.05

PF00005 (2/2) ABC transporter
PF14903 (1/2) WG containing repeat
PF14435 (1/2) SUKH-4 immunity protein
PF10042 (1/2) Uncharacterized conserved protein (DUF2278)
PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
PF05193 (1/2) Peptidase M16 inactive domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01937 (1/2) Protein of unknown function DUF89
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00950 (1/2) ABC 3 transport family
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)

precursor_groups_64854

246.49 +- 143.51

0.04 +- 0.15

PF11259 (2/2) Protein of unknown function (DUF3060)
PF04055 (2/2) Radical SAM superfamily
PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (2/2) B12 binding domain
PF01522 (2/2) Polysaccharide deacetylase
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00072 (2/2) Response regulator receiver domain
PF00583 (1/2) Acetyltransferase (GNAT) family

precursor_groups_48856

234.00 +- 26.00

0.01 +- 0.01

PF12146 (2/2) Serine aminopeptidase, S33
PF10006 (2/2) Uncharacterized conserved protein (DUF2249)
PF09339 (2/2) IclR helix-turn-helix domain
PF01979 (2/2) Amidohydrolase family
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF00899 (2/2) ThiF family

precursor_groups_279

104.13 +- 69.20

0.08 +- 0.16

TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (2/2) FAD-NAD(P)-binding
PF07920 (2/2) Protein of unknown function (DUF1684)
PF02983 (2/2) Alpha-lytic protease prodomain
PF00296 (2/2) Luciferase-like monooxygenase
PF00089 (2/2) Trypsin

precursor_groups_47384

1855.31 +- 282.62

0.04 +- 0.15

precursor_groups_13328

1552.41 +- 1036.67

0.02 +- 0.08

PF13622 (5/5) Thioesterase-like superfamily
PF07690 (5/5) Major Facilitator Superfamily
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00487 (5/5) Fatty acid desaturase
PF00301 (5/5) Rubredoxin
PF00067 (5/5) Cytochrome P450
PF12679 (4/5) ABC-2 family transporter protein
PF12146 (4/5) Serine aminopeptidase, S33
PF00005 (4/5) ABC transporter
PF00392 (3/5) Bacterial regulatory proteins, gntR family

precursor_groups_72506

195.60 +- 94.65

0.02 +- 0.02

PF12697 (2/2) Alpha/beta hydrolase family
PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (2/2) Prolyl oligopeptidase family
PF00313 (2/2) 'Cold-shock' DNA-binding domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00069 (2/2) Protein kinase domain

precursor_groups_10496

2158.41 +- 761.00

0.01 +- 0.01

PF13560 (8/8) Helix-turn-helix domain
PF13393 (8/8) Histidyl-tRNA synthetase
PF05193 (8/8) Peptidase M16 inactive domain
PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02585 (8/8) GlcNAc-PI de-N-acetylase
PF01370 (8/8) NAD dependent epimerase/dehydratase family
PF01061 (8/8) ABC-2 type transporter
PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00675 (8/8) Insulinase (Peptidase family M16)
PF00005 (8/8) ABC transporter
PF17874 (7/8) MalT-like TPR region

precursor_groups_1211

920.66 +- 794.45

0.02 +- 0.10

TIGR01554 (2/2) phage major capsid protein, HK97 family
TIGR01537 (2/2) phage portal protein, HK97 family
PF09250 (2/2) Bifunctional DNA primase/polymerase, N-terminal
PF04860 (2/2) Phage portal protein
PF04586 (2/2) Caudovirus prohead serine protease
PF01844 (2/2) HNH endonuclease
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR00621 (1/2) single-stranded DNA-binding protein
PF13481 (1/2) AAA domain
PF12728 (1/2) Helix-turn-helix domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF10145 (1/2) Phage-related minor tail protein
PF05065 (1/2) Phage capsid family
PF04851 (1/2) Type III restriction enzyme, res subunit
PF01580 (1/2) FtsK/SpoIIIE family
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01381 (1/2) Helix-turn-helix
PF01183 (1/2) Glycosyl hydrolases family 25
PF00436 (1/2) Single-strand binding protein family
PF00271 (1/2) Helicase conserved C-terminal domain

precursor_groups_4654

359.93 +- 257.30

0.04 +- 0.07

TIGR01891 (9/9) amidohydrolase
TIGR01821 (9/9) 5-aminolevulinic acid synthase
PF16884 (9/9) N-terminal domain of oxidoreductase
PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (9/9) Major Facilitator Superfamily
PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (9/9) Peptidase family M20/M25/M40
PF00155 (9/9) Aminotransferase class I and II
PF00107 (9/9) Zinc-binding dehydrogenase

precursor_groups_7635

131.54 +- 3.07

0.09 +- 0.06

precursor_groups_80912

1334.20 +- 95.80

0.02 +- 0.01

PF17914 (2/2) HopA1 effector protein family
PF13649 (2/2) Methyltransferase domain
PF12698 (2/2) ABC-2 family transporter protein
PF02441 (2/2) Flavoprotein
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF13732 (1/2) Domain of unknown function (DUF4162)
PF00196 (1/2) Bacterial regulatory proteins, luxR family

precursor_groups_84735

45.39 +- 2.39

0.04 +- 0.04

PF12697 (2/2) Alpha/beta hydrolase family
PF07063 (2/2) Domain of unknown function (DUF1338)
PF01266 (2/2) FAD dependent oxidoreductase
PF00171 (2/2) Aldehyde dehydrogenase family
PF17874 (1/2) MalT-like TPR region
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat

precursor_groups_888

174.09 +- 18.88

0.07 +- 0.09

precursor_groups_5445

48.47 +- 11.07

0.07 +- 0.10

PF03450 (7/7) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (7/7) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (7/7) [2Fe-2S] binding domain
PF01315 (7/7) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (7/7) FAD binding domain in molybdopterin dehydrogenase

Entry name	Average score	Number of operons	Number of MIBiG operons	Number of operons with antismash overlap	Nr of operons with known RiPP domains	Average COG score	Nr of operons passed filter	Common domains
jaccard_groups_437	1352.84 +- 864.00	2	0	0	0	0.01 +- 0.01	2	26 PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02515 (2/2) CoA-transferase family III PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain TIGR01930 (1/2) acetyl-CoA C-acyltransferase PF16177 (1/2) Acetyl-coenzyme A synthetase N-terminus PF13607 (1/2) Succinyl-CoA ligase like flavodoxin domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13531 (1/2) Bacterial extracellular solute-binding protein PF13380 (1/2) CoA binding domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF07729 (1/2) FCD domain PF07690 (1/2) Major Facilitator Superfamily PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF02803 (1/2) Thiolase, C-terminal domain PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01575 (1/2) MaoC like domain PF01494 (1/2) FAD binding domain PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00501 (1/2) AMP-binding enzyme PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00296 (1/2) Luciferase-like monooxygenase PF00108 (1/2) Thiolase, N-terminal domain PF00005 (1/2) ABC transporter
jaccard_groups_114	714.44 +- 930.96	4	0	2	0	0.03 +- 0.07	4	2 PF02983 (4/4) Alpha-lytic protease prodomain PF00089 (4/4) Trypsin
jaccard_groups_2124	68.58 +- 37.00	4	0	0	0	0.05 +- 0.03	4	3 PF13520 (4/4) Amino acid permease PF00202 (4/4) Aminotransferase class-III PF00171 (4/4) Aldehyde dehydrogenase family
jaccard_groups_3027	52.65 +- 10.40	3	0	0	0	0.06 +- 0.07	3	5 PF13460 (3/3) NAD(P)H-binding PF08592 (3/3) Domain of unknown function (DUF1772) PF01814 (3/3) Hemerythrin HHE cation binding domain PF12852 (2/3) Cupin PF12833 (2/3) Helix-turn-helix domain
jaccard_groups_2120	447.92 +- 197.08	2	0	2	1	0.01 +- 0.01	2	8 PF07993 (2/2) Male sterility protein PF03756 (2/2) A-factor biosynthesis hotdog domain PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF00391 (2/2) PEP-utilising enzyme, mobile domain PF00334 (2/2) Nucleoside diphosphate kinase PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain PF00881 (1/2) Nitroreductase family PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_6077	226.50 +- 31.50	2	0	0	0	0.01 +- 0.00	2	3 PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA PF00294 (2/2) pfkB family carbohydrate kinase
jaccard_groups_3186	43.41 +- 0.41	2	0	2	0	0.07 +- 0.09	2	5 PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family PF07690 (2/2) Major Facilitator Superfamily PF00905 (2/2) Penicillin binding protein transpeptidase domain PF00266 (2/2) Aminotransferase class-V PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_1447	1179.64 +- 1207.20	3	0	3	0	0.05 +- 0.14	3	11 TIGR01830 (3/3) 3-oxoacyl-[acyl-carrier-protein] reductase PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF12146 (3/3) Serine aminopeptidase, S33 PF07977 (3/3) FabA-like domain PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF01323 (3/3) DSBA-like thioredoxin domain PF00550 (3/3) Phosphopantetheine attachment site PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF02786 (2/3) Carbamoyl-phosphate synthase L chain, ATP binding domain PF00698 (2/3) Acyl transferase domain PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_2909	479.19 +- 156.31	9	0	9	9	0.02 +- 0.01	9	7 PF07690 (9/9) Major Facilitator Superfamily PF04055 (9/9) Radical SAM superfamily PF03466 (9/9) LysR substrate binding domain PF02310 (9/9) B12 binding domain PF00733 (9/9) Asparagine synthase PF00501 (9/9) AMP-binding enzyme PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3611	153.06 +- 34.46	4	0	4	0	0.06 +- 0.13	4	25 TIGR01762 (4/4) chlorinating enzyme TIGR01733 (4/4) amino acid adenylation domain TIGR01509 (4/4) HAD hydrolase, family IA, variant 3 TIGR01444 (4/4) methyltransferase, FkbM family TIGR00843 (4/4) benzoate transporter PF16990 (4/4) Carbohydrate binding module (family 35) PF13560 (4/4) Helix-turn-helix domain PF13535 (4/4) ATP-grasp domain PF13454 (4/4) FAD-NAD(P)-binding PF13419 (4/4) Haloacid dehalogenase-like hydrolase PF13193 (4/4) AMP-binding enzyme C-terminal domain PF07691 (4/4) PA14 domain PF06439 (4/4) Domain of Unknown Function (DUF1080) PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH) PF05050 (4/4) Methyltransferase FkbM domain PF04149 (4/4) Domain of unknown function (DUF397) PF03594 (4/4) Benzoate membrane transport protein PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain PF01116 (4/4) Fructose-bisphosphate aldolase class-II PF00975 (4/4) Thioesterase domain PF00892 (4/4) EamA-like transporter family PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
jaccard_groups_4237	559.06 +- 431.39	3	0	1	3	0.02 +- 0.04	3	13 PF17676 (3/3) LD-carboxypeptidase C-terminal domain PF13581 (3/3) Histidine kinase-like ATPase domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF13280 (3/3) WYL domain PF08279 (3/3) HTH domain PF04055 (3/3) Radical SAM superfamily PF02310 (3/3) B12 binding domain PF02016 (3/3) LD-carboxypeptidase N-terminal domain PF00730 (3/3) HhH-GPD superfamily base excision DNA repair protein PF00293 (3/3) NUDIX domain PF00152 (3/3) tRNA synthetases class II (D, K and N) PF00005 (3/3) ABC transporter PF03372 (2/3) Endonuclease/Exonuclease/phosphatase family
jaccard_groups_177	52.32 +- 21.97	2	0	2	0	0.05 +- 0.02	2	2 PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
jaccard_groups_171	180.52 +- 200.37	17	0	3	0	0.03 +- 0.04	17	3 PF02868 (17/17) Thermolysin metallopeptidase, alpha-helical domain PF01447 (17/17) Thermolysin metallopeptidase, catalytic domain PF07504 (15/17) Fungalysin/Thermolysin Propeptide Motif
jaccard_groups_172	131.15 +- 103.02	10	0	1	0	0.03 +- 0.04	10	3 PF11716 (10/10) Mycothiol maleylpyruvate isomerase N-terminal domain TIGR03083 (9/10) uncharacterized Actinobacterial protein TIGR03083 PF07398 (6/10) MDMPI C-terminal domain
jaccard_groups_173	330.72 +- 274.50	18	0	18	0	0.05 +- 0.15	18	11 PF16197 (18/18) Ketoacyl-synthetase C-terminal extension PF02801 (18/18) Beta-ketoacyl synthase, C-terminal domain PF00668 (18/18) Condensation domain PF00550 (18/18) Phosphopantetheine attachment site PF00109 (18/18) Beta-ketoacyl synthase, N-terminal domain TIGR01733 (17/18) amino acid adenylation domain PF13193 (17/18) AMP-binding enzyme C-terminal domain PF00698 (17/18) Acyl transferase domain PF00501 (17/18) AMP-binding enzyme PF00975 (15/18) Thioesterase domain PF07690 (10/18) Major Facilitator Superfamily
jaccard_groups_6305	121.07 +- 15.52	2	0	0	0	0.03 +- 0.05	2	8 TIGR01297 (2/2) cation diffusion facilitator family transporter PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family PF01695 (2/2) IstB-like ATP binding protein PF01545 (2/2) Cation efflux family PF00665 (2/2) Integrase core domain PF00501 (2/2) AMP-binding enzyme PF00221 (2/2) Aromatic amino acid lyase
jaccard_groups_2973	375.44 +- 131.77	2	0	2	0	0.09 +- 0.21	2	34 TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01733 (2/2) amino acid adenylation domain TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13602 (2/2) Zinc-binding dehydrogenase PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08990 (2/2) Erythronolide synthase docking PF08659 (2/2) KR domain PF08443 (2/2) RimK-like ATP-grasp domain PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01370 (2/2) NAD dependent epimerase/dehydratase family PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00975 (2/2) Thioesterase domain PF00698 (2/2) Acyl transferase domain PF00696 (2/2) Amino acid kinase family PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF00857 (1/2) Isochorismatase family
jaccard_groups_2691	259.00 +- 1.00	2	0	1	0	0.01 +- 0.00	2	4 PF13243 (2/2) Squalene-hopene cyclase C-terminal domain PF00432 (2/2) Prenyltransferase and squalene oxidase repeat PF00348 (1/2) Polyprenyl synthetase PF00293 (1/2) NUDIX domain
jaccard_groups_489	259.00 +- 1.00	2	0	0	0	0.01 +- 0.00	2	3 PF07859 (2/2) alpha/beta hydrolase fold PF00175 (2/2) Oxidoreductase NAD-binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
jaccard_groups_642	315.42 +- 243.98	35	0	2	0	0.03 +- 0.04	35	8 TIGR03920 (35/35) type VII secretion integral membrane protein EccD TIGR03919 (35/35) type VII secretion protein EccB PF08817 (35/35) WXG100 protein secretion system (Wss), protein YukD PF05108 (35/35) Type VII secretion system ESX-1, transport TM domain B PF02575 (34/35) YbaB/EbfC DNA-binding family PF06013 (29/35) Proteins of 100 residues with WXG TIGR03930 (26/35) WXG100 family type VII secretion target PF07179 (20/35) SseB protein N-terminal domain
jaccard_groups_2674	131.54 +- 3.07	2	0	0	0	0.09 +- 0.06	2	10 TIGR01382 (2/2) intracellular protease, PfpI family PF13823 (2/2) Alcohol dehydrogenase GroES-associated PF09123 (2/2) Domain of unknown function (DUF1931) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07690 (2/2) Major Facilitator Superfamily PF01965 (2/2) DJ-1/PfpI family PF00248 (2/2) Aldo/keto reductase family PF00107 (2/2) Zinc-binding dehydrogenase PF13515 (1/2) Fusaric acid resistance protein-like PF12805 (1/2) FUSC-like inner membrane protein yccS
jaccard_groups_2676	260.26 +- 108.12	9	0	9	9	0.05 +- 0.03	9	13 TIGR04451 (9/9) lantipeptide, SCO0268 family TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term PF12802 (9/9) MarR family PF12697 (9/9) Alpha/beta hydrolase family PF05147 (9/9) Lanthionine synthetase C-like protein PF04738 (9/9) Lantibiotic dehydratase, N terminus PF02065 (9/9) Melibiase PF01547 (9/9) Bacterial extracellular solute-binding protein PF00528 (9/9) Binding-protein-dependent transport system inner membrane component PF00480 (9/9) ROK family PF02894 (8/9) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (8/9) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_5583	129.86 +- 93.00	2	0	0	0	0.05 +- 0.10	2	3 PF03483 (2/2) B3/4 domain PF01810 (2/2) LysE type translocator PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
jaccard_groups_4356	777.00 +- 3.00	2	0	0	0	0.01 +- 0.00	2	8 PF14759 (2/2) Reductase C-terminal PF13279 (2/2) Thioesterase-like superfamily PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF01613 (2/2) Flavin reductase like domain PF00775 (2/2) Dioxygenase PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00067 (2/2) Cytochrome P450
jaccard_groups_2472	1010.92 +- 468.30	4	0	0	4	0.03 +- 0.04	4	25 TIGR03812 (4/4) tyrosine decarboxylase MnfA PF17755 (4/4) UvrA DNA-binding domain PF16861 (4/4) Carbamoyltransferase C-terminus PF16169 (4/4) Domain of unknown function (DUF4872) PF14399 (4/4) Butirosin biosynthesis protein H, N-terminal PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I PF11794 (4/4) 4-hydroxyphenylacetate 3-hydroxylase N terminal PF08713 (4/4) DNA alkylation repair enzyme PF08241 (4/4) Methyltransferase domain PF04879 (4/4) Molybdopterin oxidoreductase Fe4S4 domain PF04055 (4/4) Radical SAM superfamily PF03241 (4/4) 4-hydroxyphenylacetate 3-hydroxylase C terminal PF02543 (4/4) Carbamoyltransferase N-terminus PF02310 (4/4) B12 binding domain PF02195 (4/4) ParB-like nuclease domain PF01613 (4/4) Flavin reductase like domain PF01568 (4/4) Molydopterin dinucleotide binding domain PF01061 (4/4) ABC-2 type transporter PF00805 (4/4) Pentapeptide repeats (8 copies) PF00795 (4/4) Carbon-nitrogen hydrolase PF00384 (4/4) Molybdopterin oxidoreductase PF00291 (4/4) Pyridoxal-phosphate dependent enzyme PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain PF00005 (4/4) ABC transporter PF00501 (3/4) AMP-binding enzyme
jaccard_groups_5613	135.53 +- 39.47	2	0	0	0	0.06 +- 0.09	2	9 TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family PF17964 (2/2) Bacterial Ig domain PF13411 (2/2) MerR HTH family regulatory protein PF08281 (2/2) Sigma-70, region 4 PF07739 (2/2) TipAS antibiotic-recognition domain PF04542 (2/2) Sigma-70 region 2 PF03734 (2/2) L,D-transpeptidase catalytic domain PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_289	586.17 +- 706.86	6	0	0	0	0.02 +- 0.03	6	6 TIGR03930 (6/6) WXG100 family type VII secretion target PF06013 (6/6) Proteins of 100 residues with WXG TIGR03921 (5/6) type VII secretion-associated serine protease mycosin PF05108 (5/6) Type VII secretion system ESX-1, transport TM domain B PF00082 (5/6) Subtilase family TIGR03919 (4/6) type VII secretion protein EccB
jaccard_groups_5572	533.02 +- 31.35	2	0	0	0	0.01 +- 0.00	2	9 TIGR01891 (2/2) amidohydrolase PF14518 (2/2) Iron-containing redox enzyme PF07690 (2/2) Major Facilitator Superfamily PF04204 (2/2) Homoserine O-succinyltransferase PF03704 (2/2) Bacterial transcriptional activator domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme PF00931 (2/2) NB-ARC domain PF00486 (2/2) Transcriptional regulatory protein, C terminal
jaccard_groups_795	339.13 +- 0.00	2	0	0	0	0.03 +- 0.01	2	8 TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1) PF04679 (2/2) ATP dependent DNA ligase C terminal region PF04675 (2/2) DNA ligase N terminus PF01547 (2/2) Bacterial extracellular solute-binding protein PF01380 (2/2) SIS domain PF01068 (2/2) ATP dependent DNA ligase domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00294 (2/2) pfkB family carbohydrate kinase
jaccard_groups_4775	763.96 +- 609.16	2	0	2	1	0.05 +- 0.14	2	24 TIGR03696 (2/2) RHS repeat-associated core domain TIGR03494 (2/2) salicylate synthase TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family TIGR01733 (2/2) amino acid adenylation domain TIGR01643 (2/2) YD repeat (two copies) TIGR01443 (2/2) intein C-terminal splicing region PF13193 (2/2) AMP-binding enzyme C-terminal domain PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep) PF07591 (2/2) Pretoxin HINT domain PF05593 (2/2) RHS Repeat PF03704 (2/2) Bacterial transcriptional activator domain PF02361 (2/2) Cobalt transport protein PF00975 (2/2) Thioesterase domain PF00931 (2/2) NB-ARC domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00425 (2/2) chorismate binding enzyme PF00005 (2/2) ABC transporter TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing) PF13537 (1/2) Glutamine amidotransferase domain PF00733 (1/2) Asparagine synthase PF00664 (1/2) ABC transporter transmembrane region
jaccard_groups_5270	344.00 +- 86.00	2	0	0	0	0.01 +- 0.01	2	7 TIGR03696 (2/2) RHS repeat-associated core domain TIGR01643 (2/2) YD repeat (two copies) PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF13424 (2/2) Tetratricopeptide repeat PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic PF05593 (2/2) RHS Repeat PF00156 (2/2) Phosphoribosyl transferase domain
jaccard_groups_1652	427.40 +- 123.00	2	0	2	0	0.03 +- 0.03	2	6 TIGR03892 (2/2) thiazolylpeptide-type bacteriocin precursor PF13193 (2/2) AMP-binding enzyme C-terminal domain PF01959 (2/2) 3-dehydroquinate synthase II PF01791 (2/2) DeoC/LacD family aldolase PF01494 (2/2) FAD binding domain PF00501 (2/2) AMP-binding enzyme
jaccard_groups_3940	1767.52 +- 216.09	3	0	1	3	0.01 +- 0.02	3	10 TIGR00702 (3/3) YcaO-type kinase domain PF13302 (3/3) Acetyltransferase (GNAT) domain PF08007 (3/3) Cupin superfamily protein PF07812 (3/3) TfuA-like protein PF07690 (3/3) Major Facilitator Superfamily PF05193 (3/3) Peptidase M16 inactive domain PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase PF00675 (3/3) Insulinase (Peptidase family M16) PF00326 (3/3) Prolyl oligopeptidase family
jaccard_groups_594	215.75 +- 52.67	4	0	0	0	0.02 +- 0.04	4	3 TIGR03086 (4/4) TIGR03086 family protein PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain PF01814 (2/4) Hemerythrin HHE cation binding domain
jaccard_groups_4857	152.80 +- 39.15	3	0	0	0	0.03 +- 0.02	3	7 PF13377 (3/3) Periplasmic binding protein-like domain PF13185 (3/3) GAF domain PF08448 (3/3) PAS fold PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF01408 (3/3) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (3/3) Xylose isomerase-like TIM barrel PF00356 (3/3) Bacterial regulatory proteins, lacI family
jaccard_groups_5054	224.43 +- 53.86	3	0	0	0	0.03 +- 0.04	3	6 PF07690 (3/3) Major Facilitator Superfamily PF04542 (3/3) Sigma-70 region 2 PF01435 (3/3) Peptidase family M48 PF00775 (3/3) Dioxygenase PF00583 (3/3) Acetyltransferase (GNAT) family PF00196 (3/3) Bacterial regulatory proteins, luxR family
jaccard_groups_5724	766.32 +- 13.68	2	0	2	0	0.01 +- 0.00	2	13 TIGR01490 (2/2) HAD hydrolase, family IB PF12710 (2/2) haloacid dehalogenase-like hydrolase PF07690 (2/2) Major Facilitator Superfamily PF03756 (2/2) A-factor biosynthesis hotdog domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01494 (2/2) FAD binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00975 (2/2) Thioesterase domain PF00891 (2/2) O-methyltransferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00248 (2/2) Aldo/keto reductase family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_50	561.62 +- 388.29	2	0	0	0	0.01 +- 0.01	2	12 PF17853 (2/2) GGDEF-like domain PF13556 (2/2) PucR C-terminal helix-turn-helix domain PF13185 (1/2) GAF domain PF12770 (1/2) CHAT domain PF07905 (1/2) Purine catabolism regulatory protein-like family PF07690 (1/2) Major Facilitator Superfamily PF01872 (1/2) RibD C-terminal domain PF01047 (1/2) MarR family PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family PF00561 (1/2) alpha/beta hydrolase fold PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_52	45.69 +- 30.15	4	0	1	0	0.07 +- 0.09	4	5 TIGR01525 (4/4) heavy metal translocating P-type ATPase PF00702 (4/4) haloacid dehalogenase-like hydrolase PF00122 (4/4) E1-E2 ATPase PF04314 (3/4) Copper chaperone PCu(A)C PF00403 (3/4) Heavy-metal-associated domain
jaccard_groups_55	162.82 +- 79.43	8	0	0	0	0.03 +- 0.03	8	2 PF08240 (8/8) Alcohol dehydrogenase GroES-like domain PF00107 (8/8) Zinc-binding dehydrogenase
jaccard_groups_946	223.40 +- 135.81	3	0	2	0	0.03 +- 0.04	3	7 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF13535 (3/3) ATP-grasp domain PF07690 (3/3) Major Facilitator Superfamily PF18130 (2/3) ATP-grasp N-terminal domain PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family PF00392 (2/3) Bacterial regulatory proteins, gntR family PF00155 (2/3) Aminotransferase class I and II
jaccard_groups_866	47.52 +- 9.22	3	0	0	0	0.04 +- 0.05	3	3 PF09586 (3/3) Bacterial membrane protein YfhO PF04138 (3/3) GtrA-like protein PF00535 (3/3) Glycosyl transferase family 2
jaccard_groups_948	1680.69 +- 1143.93	5	0	3	5	0.04 +- 0.12	5	8 PF13649 (5/5) Methyltransferase domain PF00465 (5/5) Iron-containing alcohol dehydrogenase PF00202 (5/5) Aminotransferase class-III PF00005 (5/5) ABC transporter PF12730 (4/5) ABC-2 family transporter protein PF00296 (4/5) Luciferase-like monooxygenase PF00069 (4/5) Protein kinase domain PF05147 (3/5) Lanthionine synthetase C-like protein
jaccard_groups_864	1319.20 +- 1319.09	76	0	14	0	0.02 +- 0.04	76	9 PF17914 (75/76) HopA1 effector protein family PF02441 (74/76) Flavoprotein PF00675 (71/76) Insulinase (Peptidase family M16) PF00005 (68/76) ABC transporter PF05193 (67/76) Peptidase M16 inactive domain PF00296 (61/76) Luciferase-like monooxygenase PF13649 (43/76) Methyltransferase domain PF00664 (42/76) ABC transporter transmembrane region PF01636 (40/76) Phosphotransferase enzyme family
jaccard_groups_3200	400.13 +- 221.16	3	0	1	0	0.05 +- 0.17	3	26 TIGR02100 (3/3) glycogen debranching enzyme GlgX TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme TIGR00377 (3/3) anti-anti-sigma factor PF18085 (3/3) Maltokinase N-terminal cap domain PF17124 (3/3) ThiJ/PfpI family-like PF13614 (3/3) AAA domain PF13581 (3/3) Histidine kinase-like ATPase domain PF13546 (3/3) DDE superfamily endonuclease PF13466 (3/3) STAS domain PF13460 (3/3) NAD(P)H-binding PF13380 (3/3) CoA binding domain PF11896 (3/3) Domain of unknown function (DUF3416) PF07690 (3/3) Major Facilitator Superfamily PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) PF07110 (3/3) EthD domain PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain) PF02806 (3/3) Alpha amylase, C-terminal all-beta domain PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01965 (3/3) DJ-1/PfpI family PF01740 (3/3) STAS domain PF00483 (3/3) Nucleotidyl transferase PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain PF00132 (3/3) Bacterial transferase hexapeptide (six repeats) PF00128 (3/3) Alpha amylase, catalytic domain
jaccard_groups_219	238.29 +- 148.71	2	0	2	0	0.03 +- 0.04	2	6 PF17900 (2/2) Peptidase M1 N-terminal domain PF01433 (2/2) Peptidase family M1 domain PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF00583 (1/2) Acetyltransferase (GNAT) family PF00293 (1/2) NUDIX domain PF00067 (1/2) Cytochrome P450
jaccard_groups_216	135.76 +- 125.47	4	0	0	0	0.04 +- 0.03	4	6 PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain PF07690 (3/4) Major Facilitator Superfamily PF05721 (2/4) Phytanoyl-CoA dioxygenase (PhyH) PF00378 (2/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_212	129.71 +- 150.27	3	0	0	0	0.07 +- 0.07	3	3 PF00753 (3/3) Metallo-beta-lactamase superfamily PF13370 (2/3) 4Fe-4S single cluster domain of Ferredoxin I PF08241 (2/3) Methyltransferase domain
jaccard_groups_3386	273.84 +- 106.57	7	0	1	0	0.03 +- 0.01	7	7 PF07690 (7/7) Major Facilitator Superfamily PF05378 (7/7) Hydantoinase/oxoprolinase N-terminal region PF02538 (7/7) Hydantoinase B/oxoprolinase PF01968 (7/7) Hydantoinase/oxoprolinase PF01380 (7/7) SIS domain PF01019 (7/7) Gamma-glutamyltranspeptidase PF00294 (7/7) pfkB family carbohydrate kinase
jaccard_groups_3382	111.05 +- 61.85	5	0	0	0	0.05 +- 0.05	5	8 TIGR00350 (5/5) cell envelope-related function transcriptional attenuator common domain PF13399 (5/5) LytR cell envelope-related transcriptional attenuator PF07859 (5/5) alpha/beta hydrolase fold PF03816 (5/5) Cell envelope-related transcriptional attenuator domain PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent PF01258 (5/5) Prokaryotic dksA/traR C4-type zinc finger PF00768 (5/5) D-alanyl-D-alanine carboxypeptidase PF00459 (5/5) Inositol monophosphatase family
jaccard_groups_6289	1942.50 +- 7.50	2	0	0	0	0.01 +- 0.00	2	12 TIGR01891 (2/2) amidohydrolase TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR00004 (2/2) reactive intermediate/imine deaminase PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF05299 (2/2) M61 glycyl aminopeptidase PF01979 (2/2) Amidohydrolase family PF01546 (2/2) Peptidase family M20/M25/M40 PF01042 (2/2) Endoribonuclease L-PSP PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00266 (2/2) Aminotransferase class-V PF00005 (2/2) ABC transporter
jaccard_groups_3720	427.75 +- 162.91	4	0	0	0	0.02 +- 0.01	4	8 PF11723 (4/4) Homotrimeric ring hydroxylase PF02900 (4/4) Catalytic LigB subunit of aromatic ring-opening dioxygenase PF01546 (4/4) Peptidase family M20/M25/M40 PF00561 (4/4) alpha/beta hydrolase fold PF00355 (4/4) Rieske [2Fe-2S] domain PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain PF12697 (3/4) Alpha/beta hydrolase family PF00175 (3/4) Oxidoreductase NAD-binding domain
jaccard_groups_6235	2080.00 +- 260.00	2	0	2	2	0.01 +- 0.00	2	11 TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1 TIGR00745 (2/2) 2-dehydropantoate 2-reductase PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal PF07690 (2/2) Major Facilitator Superfamily PF04055 (2/2) Radical SAM superfamily PF02597 (2/2) ThiS family PF02558 (2/2) Ketopantoate reductase PanE/ApbA PF02310 (2/2) B12 binding domain PF00155 (2/2) Aminotransferase class I and II PF00067 (2/2) Cytochrome P450 PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_3370	332.84 +- 267.53	3	0	0	0	0.06 +- 0.12	3	18 TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain PF09339 (3/3) IclR helix-turn-helix domain PF08501 (3/3) Shikimate dehydrogenase substrate binding domain PF07836 (3/3) DmpG-like communication domain PF07690 (3/3) Major Facilitator Superfamily PF02627 (3/3) Carboxymuconolactone decarboxylase family PF01614 (3/3) Bacterial transcriptional regulator PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family PF01261 (3/3) Xylose isomerase-like TIM barrel PF01220 (3/3) Dehydroquinase class II PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00682 (3/3) HMGL-like PF00083 (3/3) Sugar (and other) transporter TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating) PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain
jaccard_groups_3371	68.23 +- 18.44	2	0	1	0	0.05 +- 0.04	2	6 TIGR00345 (2/2) transport-energizing ATPase, TRC40/GET3/ArsA family PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA PF02554 (2/2) Carbon starvation protein CstA PF02374 (2/2) Anion-transporting ATPase TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family PF08281 (1/2) Sigma-70, region 4
jaccard_groups_500	34.39 +- 12.89	2	0	2	0	0.09 +- 0.08	2	2 PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family PF01810 (2/2) LysE type translocator
jaccard_groups_509	390.00 +- 0.00	3	0	2	0	0.01 +- 0.00	3	4 PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01613 (3/3) Flavin reductase like domain PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00296 (3/3) Luciferase-like monooxygenase
jaccard_groups_1276	24.19 +- 0.00	2	0	0	0	0.08 +- 0.03	2	2 PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF01361 (2/2) Tautomerase enzyme
jaccard_groups_767	151.70 +- 47.50	3	0	0	0	0.07 +- 0.10	3	7 TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF09084 (3/3) NMT1/THI5 like PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF00296 (3/3) Luciferase-like monooxygenase PF00005 (3/3) ABC transporter PF09995 (2/3) Uncharacterized protein conserved in bacteria (DUF2236) PF05719 (2/3) Golgi phosphoprotein 3 (GPP34)
jaccard_groups_761	729.04 +- 362.80	9	0	5	9	0.05 +- 0.11	9	19 TIGR04364 (9/9) methyltransferase, FxLD system TIGR04363 (9/9) FxLD family lantipeptide TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term PF05331 (9/9) Protein of unknown function (DUF742) PF05147 (9/9) Lanthionine synthetase C-like protein PF04738 (9/9) Lantibiotic dehydratase, N terminus PF03259 (9/9) Roadblock/LC7 domain PF03029 (9/9) Conserved hypothetical ATP binding protein PF01135 (9/9) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00293 (9/9) NUDIX domain PF00196 (9/9) Bacterial regulatory proteins, luxR family PF00005 (9/9) ABC transporter PF02771 (7/9) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (7/9) Acyl-CoA dehydrogenase, middle domain PF01590 (7/9) GAF domain PF01427 (7/9) D-ala-D-ala dipeptidase PF00441 (7/9) Acyl-CoA dehydrogenase, C-terminal domain PF00723 (5/9) Glycosyl hydrolases family 15
jaccard_groups_763	1162.04 +- 959.64	85	28	57	84	0.03 +- 0.08	57	7 PF00005 (85/85) ABC transporter PF13575 (84/85) Domain of unknown function (DUF4135) PF05147 (84/85) Lanthionine synthetase C-like protein PF00664 (84/85) ABC transporter transmembrane region PF03412 (83/85) Peptidase C39 family TIGR03897 (79/85) type 2 lantibiotic biosynthesis protein LanM PF14867 (43/85) Lantibiotic alpha
jaccard_groups_139	331.74 +- 178.03	5	0	3	0	0.02 +- 0.02	5	8 PF02780 (5/5) Transketolase, C-terminal domain PF00676 (5/5) Dehydrogenase E1 component PF00364 (5/5) Biotin-requiring enzyme PF00198 (5/5) 2-oxoacid dehydrogenases acyltransferase (catalytic domain) PF02779 (4/5) Transketolase, pyrimidine binding domain PF08545 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF00550 (3/5) Phosphopantetheine attachment site
jaccard_groups_1879	1882.17 +- 1757.83	2	0	0	0	0.05 +- 0.07	2	17 PF14310 (2/2) Fibronectin type III-like domain PF13416 (2/2) Bacterial extracellular solute-binding protein PF13377 (2/2) Periplasmic binding protein-like domain PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain PF13802 (1/2) Galactose mutarotase-like PF08244 (1/2) Glycosyl hydrolases family 32 C terminal PF07690 (1/2) Major Facilitator Superfamily PF03422 (1/2) Carbohydrate binding module (family 6) PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain PF01833 (1/2) IPT/TIG domain PF01055 (1/2) Glycosyl hydrolases family 31 PF00754 (1/2) F5/8 type C domain PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain
jaccard_groups_6462	50.96 +- 10.96	2	0	0	0	0.06 +- 0.07	2	4 PF11303 (2/2) Protein of unknown function (DUF3105) PF09335 (2/2) SNARE associated Golgi protein PF02388 (2/2) FemAB family PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
jaccard_groups_3129	864.29 +- 155.78	3	0	3	3	0.01 +- 0.02	3	9 TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (3/3) Iron-sulfur cluster-binding domain PF08241 (3/3) Methyltransferase domain PF07690 (3/3) Major Facilitator Superfamily PF04055 (3/3) Radical SAM superfamily PF01980 (3/3) tRNA-methyltransferase O PF01494 (3/3) FAD binding domain PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain PF00440 (2/3) Bacterial regulatory proteins, tetR family
jaccard_groups_3796	214.87 +- 119.93	4	0	0	0	0.02 +- 0.03	4	4 PF05901 (4/4) Excalibur calcium-binding domain PF01738 (4/4) Dienelactone hydrolase family PF00293 (4/4) NUDIX domain PF00067 (2/4) Cytochrome P450
jaccard_groups_6512	101.28 +- 23.28	2	0	0	2	0.05 +- 0.10	2	8 PF13581 (2/2) Histidine kinase-like ATPase domain PF13191 (2/2) AAA ATPase domain PF09346 (2/2) SMI1 / KNR4 family (SUKH-1) PF05147 (2/2) Lanthionine synthetase C-like protein PF00561 (2/2) alpha/beta hydrolase fold PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF04978 (1/2) Protein of unknown function (DUF664)
jaccard_groups_2010	142.50 +- 52.50	2	0	0	0	0.05 +- 0.07	2	18 TIGR00167 (2/2) ketose-bisphosphate aldolase PF17042 (2/2) Nucleotide-binding C-terminal domain PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PF07729 (2/2) FCD domain PF07005 (2/2) Sugar-binding N-terminal domain PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase PF02447 (2/2) GntP family permease PF01116 (2/2) Fructose-bisphosphate aldolase class-II PF00392 (2/2) Bacterial regulatory proteins, gntR family TIGR00791 (1/2) transporter, gluconate:H+ symporter (GntP) family PF13581 (1/2) Histidine kinase-like ATPase domain PF13407 (1/2) Periplasmic binding protein domain PF13185 (1/2) GAF domain PF09339 (1/2) IclR helix-turn-helix domain PF08447 (1/2) PAS fold PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF01614 (1/2) Bacterial transcriptional regulator PF00775 (1/2) Dioxygenase
jaccard_groups_3159	284.37 +- 95.70	5	0	1	0	0.03 +- 0.05	5	8 PF12833 (5/5) Helix-turn-helix domain PF02774 (5/5) Semialdehyde dehydrogenase, dimerisation domain PF01965 (5/5) DJ-1/PfpI family PF01118 (5/5) Semialdehyde dehydrogenase, NAD binding domain PF00696 (5/5) Amino acid kinase family PF00196 (5/5) Bacterial regulatory proteins, luxR family PF00171 (5/5) Aldehyde dehydrogenase family PF00465 (4/5) Iron-containing alcohol dehydrogenase
jaccard_groups_2206	139.29 +- 9.29	2	0	0	0	0.03 +- 0.02	2	7 PF13460 (2/2) NAD(P)H-binding PF00561 (2/2) alpha/beta hydrolase fold TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF07690 (1/2) Major Facilitator Superfamily PF01814 (1/2) Hemerythrin HHE cation binding domain PF01494 (1/2) FAD binding domain
jaccard_groups_1473	113.82 +- 0.00	2	0	0	0	0.08 +- 0.05	2	6 PF13378 (2/2) Enolase C-terminal domain-like PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01547 (2/2) Bacterial extracellular solute-binding protein PF00701 (2/2) Dihydrodipicolinate synthetase family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF04203 (1/2) Sortase domain
jaccard_groups_1478	1029.59 +- 549.79	5	2	3	5	0.03 +- 0.03	3	10 PF13471 (5/5) Transglutaminase-like superfamily PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD) PF01061 (5/5) ABC-2 type transporter PF00733 (5/5) Asparagine synthase PF00005 (5/5) ABC transporter TIGR01188 (3/5) daunorubicin resistance ABC transporter, ATP-binding protein PF13462 (3/5) Thioredoxin PF07730 (3/5) Histidine kinase PF00196 (3/5) Bacterial regulatory proteins, luxR family PF00072 (3/5) Response regulator receiver domain
jaccard_groups_997	144.69 +- 113.31	2	0	0	0	0.04 +- 0.06	2	5 PF18593 (2/2) CdiI immunity protein PF18431 (2/2) Bacterial CdiA-CT RNAse A domain PF13560 (2/2) Helix-turn-helix domain PF06013 (2/2) Proteins of 100 residues with WXG PF04149 (2/2) Domain of unknown function (DUF397)
jaccard_groups_994	250.84 +- 78.71	6	0	0	0	0.03 +- 0.11	6	16 TIGR01558 (6/6) putative phage terminase, small subunit, P27 family TIGR01554 (6/6) phage major capsid protein, HK97 family TIGR01543 (6/6) phage prohead protease, HK97 family TIGR01537 (6/6) phage portal protein, HK97 family PF10145 (6/6) Phage-related minor tail protein PF05119 (6/6) Phage terminase, small subunit PF05065 (6/6) Phage capsid family PF04860 (6/6) Phage portal protein PF04586 (6/6) Caudovirus prohead serine protease PF03354 (6/6) Phage Terminase PF01510 (6/6) N-acetylmuramoyl-L-alanine amidase PF01381 (6/6) Helix-turn-helix PF16945 (4/6) Putative lactococcus lactis phage r1t holin PF13229 (4/6) Right handed beta helix region PF01476 (4/6) LysM domain PF01464 (4/6) Transglycosylase SLT domain
jaccard_groups_5913	647.50 +- 2.50	2	0	0	0	0.01 +- 0.00	2	10 TIGR03923 (2/2) type VII secretion protein EccE TIGR03921 (2/2) type VII secretion-associated serine protease mycosin TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE PF04545 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF03640 (2/2) Secreted repeat of unknown function PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily PF00082 (2/2) Subtilase family
jaccard_groups_993	66.40 +- 35.34	2	0	1	0	0.06 +- 0.08	2	13 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF07690 (2/2) Major Facilitator Superfamily PF03771 (2/2) Domain of unknown function (DUF317) PF01638 (2/2) HxlR-like helix-turn-helix TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 PF16259 (1/2) Domain of unknown function (DUF4913) PF13649 (1/2) Methyltransferase domain PF13620 (1/2) Carboxypeptidase regulatory-like domain PF13419 (1/2) Haloacid dehalogenase-like hydrolase PF12307 (1/2) Protein of unknown function (DUF3631) PF08239 (1/2) Bacterial SH3 domain PF01555 (1/2) DNA methylase
jaccard_groups_4482	1855.31 +- 282.62	3	0	3	0	0.04 +- 0.15	3	33 TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR01733 (3/3) amino acid adenylation domain TIGR01686 (3/3) FkbH domain TIGR00976 (3/3) hydrolase CocE/NonD family protein PF18563 (3/3) TubC N-terminal docking domain PF16197 (3/3) Ketoacyl-synthetase C-terminal extension PF14765 (3/3) Polyketide synthase dehydratase PF13602 (3/3) Zinc-binding dehydrogenase PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08659 (3/3) KR domain PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF03621 (3/3) MbtH-like protein PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02195 (3/3) ParB-like nuclease domain PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family) PF01266 (3/3) FAD dependent oxidoreductase PF00975 (3/3) Thioesterase domain PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (3/3) Acyl transferase domain PF00668 (3/3) Condensation domain PF00664 (3/3) ABC transporter transmembrane region PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain PF00296 (3/3) Luciferase-like monooxygenase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF00005 (3/3) ABC transporter
jaccard_groups_4093	886.61 +- 688.91	3	0	0	0	0.03 +- 0.01	3	18 TIGR03561 (3/3) peroxiredoxin, Ohr subfamily PF13649 (3/3) Methyltransferase domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF09339 (3/3) IclR helix-turn-helix domain PF09084 (3/3) NMT1/THI5 like PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase PF02566 (3/3) OsmC-like protein PF01614 (3/3) Bacterial transcriptional regulator PF01546 (3/3) Peptidase family M20/M25/M40 PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family PF00561 (3/3) alpha/beta hydrolase fold PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF00005 (3/3) ABC transporter PF04199 (2/3) Putative cyclase PF03972 (2/3) MmgE/PrpD family PF03328 (2/3) HpcH/HpaI aldolase/citrate lyase family PF02515 (2/3) CoA-transferase family III PF01979 (2/3) Amidohydrolase family
jaccard_groups_4722	146.32 +- 79.43	2	0	0	2	0.04 +- 0.06	2	7 TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family TIGR04186 (2/2) putative ATP-grasp target RiPP TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family PF07702 (2/2) UTRA domain PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_5898	600.85 +- 188.32	2	0	0	0	0.03 +- 0.04	2	20 TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR00738 (2/2) Rrf2 family protein PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain PF13743 (2/2) Thioredoxin PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02082 (2/2) Transcriptional regulator PF01613 (2/2) Flavin reductase like domain PF01568 (2/2) Molydopterin dinucleotide binding domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00384 (2/2) Molybdopterin oxidoreductase PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter PF13427 (1/2) Domain of unknown function (DUF4111) PF12146 (1/2) Serine aminopeptidase, S33 PF08386 (1/2) TAP-like protein PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF01909 (1/2) Nucleotidyltransferase domain
jaccard_groups_1054	156.96 +- 65.90	2	0	0	0	0.02 +- 0.03	2	4 PF07582 (2/2) AP endonuclease family 2 C terminus PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel
jaccard_groups_1976	100.79 +- 5.13	2	0	0	0	0.06 +- 0.07	2	14 TIGR01891 (2/2) amidohydrolase PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF13302 (2/2) Acetyltransferase (GNAT) domain PF13091 (2/2) PLD-like domain PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF06267 (2/2) Family of unknown function (DUF1028) PF03466 (2/2) LysR substrate binding domain PF02386 (2/2) Cation transport protein PF02254 (2/2) TrkA-N domain PF02080 (2/2) TrkA-C domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01042 (2/2) Endoribonuclease L-PSP PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00083 (2/2) Sugar (and other) transporter
jaccard_groups_2336	40.24 +- 11.75	3	0	0	0	0.08 +- 0.17	3	3 TIGR03296 (3/3) M6 family metalloprotease domain PF09339 (3/3) IclR helix-turn-helix domain PF03777 (3/3) ChpA-C
jaccard_groups_1114	241.84 +- 175.07	6	0	0	0	0.05 +- 0.05	6	10 PF16353 (6/6) Domain of unknown function(DUF4981) PF02929 (6/6) Beta galactosidase small chain PF02837 (6/6) Glycosyl hydrolases family 2, sugar binding domain PF02836 (6/6) Glycosyl hydrolases family 2, TIM barrel domain PF00703 (4/6) Glycosyl hydrolases family 2 PF13385 (3/6) Concanavalin A-like lectin/glucanases superfamily PF09995 (3/6) Uncharacterized protein conserved in bacteria (DUF2236) PF01547 (3/6) Bacterial extracellular solute-binding protein PF01074 (3/6) Glycosyl hydrolases family 38 N-terminal domain PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
jaccard_groups_2849	98.93 +- 27.86	3	0	3	0	0.05 +- 0.05	3	6 PF18085 (3/3) Maltokinase N-terminal cap domain PF05547 (3/3) Immune inhibitor A peptidase M6 PF01433 (3/3) Peptidase family M1 domain PF08241 (2/3) Methyltransferase domain PF01183 (2/3) Glycosyl hydrolases family 25 PF00892 (2/3) EamA-like transporter family
jaccard_groups_4006	502.26 +- 347.48	5	0	5	0	0.05 +- 0.18	5	17 TIGR01509 (5/5) HAD hydrolase, family IA, variant 3 PF13419 (5/5) Haloacid dehalogenase-like hydrolase PF13191 (5/5) AAA ATPase domain PF12710 (5/5) haloacid dehalogenase-like hydrolase PF07690 (5/5) Major Facilitator Superfamily PF04321 (5/5) RmlD substrate binding domain PF01979 (5/5) Amidohydrolase family PF00535 (5/5) Glycosyl transferase family 2 PF00480 (5/5) ROK family PF00459 (5/5) Inositol monophosphatase family PF00294 (5/5) pfkB family carbohydrate kinase PF00202 (5/5) Aminotransferase class-III PF00196 (5/5) Bacterial regulatory proteins, luxR family PF13632 (4/5) Glycosyl transferase family group 2 TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent PF03971 (3/5) Monomeric isocitrate dehydrogenase PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_1505	104.64 +- 38.90	15	0	0	0	0.06 +- 0.07	15	9 PF14158 (15/15) YndJ-like protein PF13581 (15/15) Histidine kinase-like ATPase domain PF13492 (15/15) GAF domain PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain PF09348 (15/15) Domain of unknown function (DUF1990) PF08447 (15/15) PAS fold PF07228 (15/15) Stage II sporulation protein E (SpoIIE) PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase PF00149 (15/15) Calcineurin-like phosphoesterase
jaccard_groups_618	32.06 +- 9.93	8	0	0	0	0.07 +- 0.05	8	4 PF17074 (8/8) Darcynin, domain of unknown function PF08021 (8/8) Siderophore-interacting FAD-binding domain PF04954 (8/8) Siderophore-interacting protein PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_610	172.00 +- 34.40	2	0	0	0	0.02 +- 0.03	2	5 PF00891 (2/2) O-methyltransferase domain PF16864 (1/2) Dimerisation domain PF13649 (1/2) Methyltransferase domain PF05090 (1/2) Vitamin K-dependent gamma-carboxylase PF01212 (1/2) Beta-eliminating lyase
jaccard_groups_616	226.60 +- 172.94	7	3	3	0	0.03 +- 0.04	4	5 PF13649 (7/7) Methyltransferase domain PF00005 (7/7) ABC transporter PF12697 (5/7) Alpha/beta hydrolase family PF13450 (4/7) NAD(P)-binding Rossmann-like domain PF00664 (4/7) ABC transporter transmembrane region
jaccard_groups_2522	637.59 +- 4.54	2	0	0	0	0.03 +- 0.02	2	14 TIGR00928 (2/2) adenylosuccinate lyase TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13673 (2/2) Acetyltransferase (GNAT) domain PF13460 (2/2) NAD(P)H-binding PF12800 (2/2) 4Fe-4S binding domain PF07690 (2/2) Major Facilitator Superfamily PF01814 (2/2) Hemerythrin HHE cation binding domain PF01494 (2/2) FAD binding domain PF01425 (2/2) Amidase PF00561 (2/2) alpha/beta hydrolase fold PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00206 (2/2) Lyase PF00120 (2/2) Glutamine synthetase, catalytic domain PF00072 (2/2) Response regulator receiver domain
jaccard_groups_5316	182.05 +- 34.62	2	0	0	0	0.02 +- 0.02	2	6 TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family PF17148 (2/2) Domain of unknown function (DUF5117) PF16313 (2/2) Met-zincin PF07702 (2/2) UTRA domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00296 (2/2) Luciferase-like monooxygenase
jaccard_groups_4266	179.53 +- 21.38	2	0	2	0	0.08 +- 0.15	2	12 PF13641 (2/2) Glycosyltransferase like family 2 PF10823 (2/2) Protein of unknown function (DUF2568) PF09335 (2/2) SNARE associated Golgi protein PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF01810 (2/2) LysE type translocator PF01547 (2/2) Bacterial extracellular solute-binding protein PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00925 (2/2) GTP cyclohydrolase II PF00583 (2/2) Acetyltransferase (GNAT) family PF00400 (2/2) WD domain, G-beta repeat PF00067 (2/2) Cytochrome P450
jaccard_groups_61	94.60 +- 8.60	2	0	1	0	0.02 +- 0.02	2	4 PF13302 (2/2) Acetyltransferase (GNAT) domain PF18029 (1/2) Glyoxalase-like domain PF01636 (1/2) Phosphotransferase enzyme family PF00156 (1/2) Phosphoribosyl transferase domain
jaccard_groups_5094	154.25 +- 11.20	2	0	2	0	0.05 +- 0.16	2	19 TIGR03026 (2/2) nucleotide sugar dehydrogenase TIGR01733 (2/2) amino acid adenylation domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13469 (2/2) Sulfotransferase family PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02615 (2/2) Malate/L-lactate dehydrogenase PF01522 (2/2) Polysaccharide deacetylase PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_18	38.61 +- 19.66	3	0	0	0	0.07 +- 0.07	3	4 PF00271 (3/3) Helicase conserved C-terminal domain PF00270 (3/3) DEAD/DEAH box helicase PF10923 (2/3) P-loop Domain of unknown function (DUF2791) PF09848 (2/3) Uncharacterized conserved protein (DUF2075)
jaccard_groups_19	138.16 +- 77.48	8	1	3	0	0.05 +- 0.10	7	5 PF07228 (7/8) Stage II sporulation protein E (SpoIIE) PF08448 (6/8) PAS fold TIGR00229 (5/8) PAS domain S-box protein PF13581 (5/8) Histidine kinase-like ATPase domain PF13185 (4/8) GAF domain
jaccard_groups_14	412.84 +- 268.06	10	0	2	1	0.03 +- 0.04	10	6 PF13377 (10/10) Periplasmic binding protein-like domain PF00356 (10/10) Bacterial regulatory proteins, lacI family PF00528 (7/10) Binding-protein-dependent transport system inner membrane component PF02065 (6/10) Melibiase PF00266 (6/10) Aminotransferase class-V PF13416 (5/10) Bacterial extracellular solute-binding protein
jaccard_groups_1609	164.29 +- 96.60	9	0	0	0	0.05 +- 0.04	9	11 TIGR03217 (9/9) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (9/9) acetaldehyde dehydrogenase (acetylating) PF13621 (9/9) Cupin-like domain PF09290 (9/9) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF07836 (9/9) DmpG-like communication domain PF07690 (9/9) Major Facilitator Superfamily PF03328 (9/9) HpcH/HpaI aldolase/citrate lyase family PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family PF01118 (9/9) Semialdehyde dehydrogenase, NAD binding domain PF00682 (9/9) HMGL-like PF00155 (9/9) Aminotransferase class I and II
jaccard_groups_16	107.91 +- 40.97	3	0	0	0	0.05 +- 0.04	3	2 PF03466 (3/3) LysR substrate binding domain PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1975	343.46 +- 204.82	9	0	7	8	0.02 +- 0.04	9	6 PF13191 (9/9) AAA ATPase domain PF00211 (9/9) Adenylate and Guanylate cyclase catalytic domain PF00082 (9/9) Subtilase family PF13185 (8/9) GAF domain PF04055 (8/9) Radical SAM superfamily PF14518 (5/9) Iron-containing redox enzyme
jaccard_groups_10	281.67 +- 272.44	6	0	2	1	0.04 +- 0.08	6	5 PF03704 (5/6) Bacterial transcriptional activator domain PF00486 (5/6) Transcriptional regulatory protein, C terminal PF00931 (4/6) NB-ARC domain PF13424 (3/6) Tetratricopeptide repeat PF00082 (3/6) Subtilase family
jaccard_groups_11	230.60 +- 200.58	12	0	3	2	0.05 +- 0.09	12	5 PF02518 (12/12) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00512 (12/12) His Kinase A (phospho-acceptor) domain PF00486 (12/12) Transcriptional regulatory protein, C terminal PF00072 (12/12) Response regulator receiver domain PF00672 (11/12) HAMP domain
jaccard_groups_3908	1645.66 +- 1357.34	2	0	2	1	0.05 +- 0.19	2	38 TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01733 (2/2) amino acid adenylation domain TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family TIGR00761 (2/2) acetylglutamate kinase PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08443 (2/2) RimK-like ATP-grasp domain PF05977 (2/2) Transmembrane secretion effector PF02780 (2/2) Transketolase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00975 (2/2) Thioesterase domain PF00696 (2/2) Amino acid kinase family PF00668 (2/2) Condensation domain PF00583 (2/2) Acetyltransferase (GNAT) family PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00067 (2/2) Cytochrome P450 TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1 TIGR02039 (1/2) sulfate adenylyltransferase, small subunit TIGR02034 (1/2) sulfate adenylyltransferase, large subunit TIGR00455 (1/2) adenylyl-sulfate kinase PF18029 (1/2) Glyoxalase-like domain PF07690 (1/2) Major Facilitator Superfamily PF04055 (1/2) Radical SAM superfamily PF02310 (1/2) B12 binding domain PF01583 (1/2) Adenylylsulphate kinase PF01507 (1/2) Phosphoadenosine phosphosulfate reductase family PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00326 (1/2) Prolyl oligopeptidase family PF00009 (1/2) Elongation factor Tu GTP binding domain
jaccard_groups_1501	120.00 +- 0.00	2	0	0	0	0.10 +- 0.25	2	12 TIGR00229 (2/2) PAS domain S-box protein PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796) PF03098 (2/2) Animal haem peroxidase PF02585 (2/2) GlcNAc-PI de-N-acetylase PF01061 (2/2) ABC-2 type transporter PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00582 (2/2) Universal stress protein family PF00199 (2/2) Catalase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF08448 (1/2) PAS fold PF00989 (1/2) PAS fold
jaccard_groups_5008	765.63 +- 127.45	2	0	1	0	0.01 +- 0.01	2	8 PF11953 (2/2) Domain of unknown function (DUF3470) PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02597 (2/2) ThiS family PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00037 (2/2) 4Fe-4S binding domain PF00550 (1/2) Phosphopantetheine attachment site
jaccard_groups_5003	650.00 +- 0.00	2	0	0	0	0.02 +- 0.00	2	6 TIGR01484 (2/2) HAD hydrolase, family IIB PF08282 (2/2) haloacid dehalogenase-like hydrolase PF07690 (2/2) Major Facilitator Superfamily PF01259 (2/2) SAICAR synthetase PF00326 (2/2) Prolyl oligopeptidase family PF00106 (2/2) short chain dehydrogenase
jaccard_groups_4865	738.11 +- 238.15	3	0	3	0	0.01 +- 0.01	3	13 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF13535 (3/3) ATP-grasp domain PF13394 (3/3) 4Fe-4S single cluster domain PF07690 (3/3) Major Facilitator Superfamily PF06508 (3/3) Queuosine biosynthesis protein QueC PF06368 (3/3) Methylaspartate mutase E chain (MutE) PF02310 (3/3) B12 binding domain PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase PF01227 (3/3) GTP cyclohydrolase I PF00668 (3/3) Condensation domain PF00501 (3/3) AMP-binding enzyme PF00487 (3/3) Fatty acid desaturase
jaccard_groups_1232	71.67 +- 26.71	5	0	0	0	0.06 +- 0.07	5	4 PF14534 (5/5) Domain of unknown function (DUF4440) PF08002 (5/5) Protein of unknown function (DUF1697) PF05922 (5/5) Peptidase inhibitor I9 PF00082 (5/5) Subtilase family
jaccard_groups_3541	108.35 +- 37.40	3	0	1	0	0.09 +- 0.06	3	5 PF13411 (3/3) MerR HTH family regulatory protein PF03476 (3/3) MOSC N-terminal beta barrel domain PF03473 (3/3) MOSC domain PF01551 (3/3) Peptidase family M23 PF00248 (3/3) Aldo/keto reductase family
jaccard_groups_3340	371.41 +- 284.77	6	0	0	0	0.03 +- 0.08	6	16 TIGR01060 (6/6) phosphopyruvate hydratase PF18603 (6/6) L-amino acid ligase C-terminal domain 2 PF18130 (6/6) ATP-grasp N-terminal domain PF16861 (6/6) Carbamoyltransferase C-terminus PF14518 (6/6) Iron-containing redox enzyme PF13535 (6/6) ATP-grasp domain PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family PF07690 (6/6) Major Facilitator Superfamily PF06089 (6/6) L-asparaginase II PF03952 (6/6) Enolase, N-terminal domain PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02543 (6/6) Carbamoyltransferase N-terminus PF00291 (6/6) Pyridoxal-phosphate dependent enzyme PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain PF00113 (6/6) Enolase, C-terminal TIM barrel domain
jaccard_groups_6243	107.29 +- 28.50	2	0	2	2	0.04 +- 0.04	2	10 TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family TIGR00229 (2/2) PAS domain S-box protein PF08448 (2/2) PAS fold PF08447 (2/2) PAS fold PF08386 (2/2) TAP-like protein PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF05147 (2/2) Lanthionine synthetase C-like protein PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00561 (2/2) alpha/beta hydrolase fold PF00069 (2/2) Protein kinase domain
jaccard_groups_4892	1018.46 +- 114.56	3	0	0	3	0.01 +- 0.00	3	9 PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily PF07690 (3/3) Major Facilitator Superfamily PF05193 (3/3) Peptidase M16 inactive domain PF04055 (3/3) Radical SAM superfamily PF00899 (3/3) ThiF family PF00675 (3/3) Insulinase (Peptidase family M16) PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle PF02310 (2/3) B12 binding domain
jaccard_groups_800	90.32 +- 12.32	2	0	1	0	0.03 +- 0.02	2	5 PF14759 (2/2) Reductase C-terminal PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF00355 (2/2) Rieske [2Fe-2S] domain PF14518 (1/2) Iron-containing redox enzyme PF00083 (1/2) Sugar (and other) transporter
jaccard_groups_4890	1430.00 +- 130.00	2	0	2	2	0.01 +- 0.00	2	16 TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase PF18105 (2/2) PGM1 C-terminal domain PF16861 (2/2) Carbamoyltransferase C-terminus PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF06969 (2/2) HemN C-terminal domain PF05977 (2/2) Transmembrane secretion effector PF04055 (2/2) Radical SAM superfamily PF02543 (2/2) Carbamoyltransferase N-terminus PF00975 (2/2) Thioesterase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00425 (2/2) chorismate binding enzyme PF00117 (2/2) Glutamine amidotransferase class-I PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
jaccard_groups_4895	151.88 +- 91.88	2	0	0	0	0.04 +- 0.05	2	11 PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07690 (2/2) Major Facilitator Superfamily PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator PF02913 (2/2) FAD linked oxidases, C-terminal domain PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF01565 (2/2) FAD binding domain PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain PF13333 (1/2) Integrase core domain PF13276 (1/2) HTH-like domain PF01527 (1/2) Transposase PF00665 (1/2) Integrase core domain
jaccard_groups_677	115.84 +- 70.48	5	0	3	5	0.03 +- 0.05	5	3 PF13537 (5/5) Glutamine amidotransferase domain PF00733 (5/5) Asparagine synthase PF00171 (3/5) Aldehyde dehydrogenase family
jaccard_groups_546	169.85 +- 94.28	4	0	3	0	0.04 +- 0.04	4	3 PF03033 (4/4) Glycosyltransferase family 28 N-terminal domain PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase PF00756 (3/4) Putative esterase
jaccard_groups_269	271.71 +- 249.02	8	0	1	0	0.04 +- 0.07	8	3 PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family) TIGR00976 (6/8) hydrolase CocE/NonD family protein
jaccard_groups_402	569.24 +- 406.57	4	0	2	0	0.05 +- 0.06	4	5 PF08532 (4/4) Beta-galactosidase trimerisation domain PF02449 (4/4) Beta-galactosidase PF00528 (4/4) Binding-protein-dependent transport system inner membrane component PF08533 (3/4) Beta-galactosidase C-terminal domain PF01547 (3/4) Bacterial extracellular solute-binding protein
jaccard_groups_6019	1040.00 +- 0.00	2	0	0	2	0.01 +- 0.00	2	6 TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF07690 (2/2) Major Facilitator Superfamily PF05193 (2/2) Peptidase M16 inactive domain PF03358 (2/2) NADPH-dependent FMN reductase PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00675 (2/2) Insulinase (Peptidase family M16)
jaccard_groups_2069	77.88 +- 16.58	6	0	0	0	0.08 +- 0.04	6	9 TIGR02133 (6/6) ribose 5-phosphate isomerase PF16896 (6/6) Phosphogluconate dehydrogenase (decarboxylating) C-term PF07690 (6/6) Major Facilitator Superfamily PF03807 (6/6) NADP oxidoreductase coenzyme F420-dependent PF02734 (6/6) DAK2 domain PF02733 (6/6) Dak1 domain PF02502 (6/6) Ribose/Galactose Isomerase PF01261 (6/6) Xylose isomerase-like TIM barrel PF00121 (6/6) Triosephosphate isomerase
jaccard_groups_2068	249.70 +- 143.29	3	0	0	0	0.05 +- 0.05	3	18 TIGR03425 (3/3) urea carboxylase-associated protein 2 TIGR03424 (3/3) urea carboxylase-associated protein 1 TIGR02712 (3/3) urea carboxylase TIGR01930 (3/3) acetyl-CoA C-acyltransferase TIGR01509 (3/3) HAD hydrolase, family IA, variant 3 PF13520 (3/3) Amino acid permease PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF09347 (3/3) Domain of unknown function (DUF1989) PF02803 (3/3) Thiolase, C-terminal domain PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain PF02785 (3/3) Biotin carboxylase C-terminal domain PF02682 (3/3) Carboxyltransferase domain, subdomain C and D PF02626 (3/3) Carboxyltransferase domain, subdomain A and B PF01425 (3/3) Amidase PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00364 (3/3) Biotin-requiring enzyme PF00289 (3/3) Biotin carboxylase, N-terminal domain PF00108 (3/3) Thiolase, N-terminal domain
jaccard_groups_2064	359.93 +- 257.30	9	0	9	0	0.04 +- 0.07	9	10 TIGR01891 (9/9) amidohydrolase TIGR01821 (9/9) 5-aminolevulinic acid synthase PF16884 (9/9) N-terminal domain of oxidoreductase PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07690 (9/9) Major Facilitator Superfamily PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (9/9) Peptidase family M20/M25/M40 PF00155 (9/9) Aminotransferase class I and II PF00107 (9/9) Zinc-binding dehydrogenase
jaccard_groups_3164	378.11 +- 182.20	6	0	6	0	0.02 +- 0.03	6	10 PF13450 (6/6) NAD(P)-binding Rossmann-like domain PF07690 (6/6) Major Facilitator Superfamily PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH) PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family PF00348 (6/6) Polyprenyl synthetase PF00106 (6/6) short chain dehydrogenase PF00743 (5/6) Flavin-binding monooxygenase-like TIGR01534 (4/6) glyceraldehyde-3-phosphate dehydrogenase, type I PF02800 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PF00044 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
jaccard_groups_3690	215.27 +- 98.42	5	0	5	4	0.04 +- 0.05	5	11 TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family PF10025 (5/5) Uncharacterized conserved protein (DUF2267) PF08281 (5/5) Sigma-70, region 4 PF04542 (5/5) Sigma-70 region 2 PF00355 (5/5) Rieske [2Fe-2S] domain PF00067 (5/5) Cytochrome P450 TIGR03975 (4/5) ribosomal peptide maturation radical SAM protein 1 PF07690 (4/5) Major Facilitator Superfamily PF04055 (4/5) Radical SAM superfamily PF02310 (4/5) B12 binding domain PF00326 (4/5) Prolyl oligopeptidase family
jaccard_groups_3647	447.82 +- 139.46	3	0	1	0	0.06 +- 0.21	3	11 PF17914 (3/3) HopA1 effector protein family PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF02441 (3/3) Flavoprotein PF01636 (3/3) Phosphotransferase enzyme family PF00326 (3/3) Prolyl oligopeptidase family PF00296 (3/3) Luciferase-like monooxygenase PF07730 (2/3) Histidine kinase PF01061 (2/3) ABC-2 type transporter PF00196 (2/3) Bacterial regulatory proteins, luxR family PF00072 (2/3) Response regulator receiver domain PF00005 (2/3) ABC transporter
jaccard_groups_104	29.41 +- 3.34	3	0	0	0	0.08 +- 0.06	3	3 PF13602 (3/3) Zinc-binding dehydrogenase PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF00106 (2/3) short chain dehydrogenase
jaccard_groups_3587	187.56 +- 79.93	4	0	0	0	0.03 +- 0.04	4	5 PF06628 (4/4) Catalase-related immune-responsive PF01475 (4/4) Ferric uptake regulator family PF00248 (4/4) Aldo/keto reductase family PF00199 (4/4) Catalase PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
jaccard_groups_6495	64.13 +- 5.87	2	0	0	0	0.06 +- 0.13	2	8 TIGR00753 (2/2) undecaprenyl-diphosphatase UppP PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF12840 (2/2) Helix-turn-helix domain PF07728 (2/2) AAA domain (dynein-related subfamily) PF03088 (2/2) Strictosidine synthase PF02673 (2/2) Bacitracin resistance protein BacA
jaccard_groups_3568	491.70 +- 429.24	5	0	0	0	0.02 +- 0.05	5	12 TIGR01509 (5/5) HAD hydrolase, family IA, variant 3 TIGR00879 (5/5) MFS transporter, sugar porter (SP) family PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF13419 (5/5) Haloacid dehalogenase-like hydrolase PF05199 (5/5) GMC oxidoreductase PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold PF00732 (5/5) GMC oxidoreductase PF00682 (5/5) HMGL-like PF00293 (5/5) NUDIX domain PF00083 (5/5) Sugar (and other) transporter PF01761 (4/5) 3-dehydroquinate synthase
jaccard_groups_163	146.25 +- 113.75	2	0	0	0	0.03 +- 0.05	2	4 PF05685 (2/2) Putative restriction endonuclease PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE PF04149 (1/2) Domain of unknown function (DUF397) PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_2368	94.90 +- 28.28	4	0	0	0	0.04 +- 0.02	4	6 PF12697 (4/4) Alpha/beta hydrolase family PF07729 (4/4) FCD domain PF06684 (4/4) Amino acid synthesis PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00296 (4/4) Luciferase-like monooxygenase PF00171 (4/4) Aldehyde dehydrogenase family
jaccard_groups_160	258.67 +- 0.94	3	0	0	0	0.01 +- 0.00	3	2 PF01757 (3/3) Acyltransferase family PF00248 (3/3) Aldo/keto reductase family
jaccard_groups_1491	1089.57 +- 871.67	7	0	7	0	0.01 +- 0.00	7	6 PF03412 (7/7) Peptidase C39 family PF00668 (7/7) Condensation domain PF00664 (7/7) ABC transporter transmembrane region PF00550 (7/7) Phosphopantetheine attachment site PF00501 (7/7) AMP-binding enzyme PF00005 (7/7) ABC transporter
jaccard_groups_165	144.63 +- 101.54	4	0	2	1	0.04 +- 0.04	4	7 TIGR03026 (4/4) nucleotide sugar dehydrogenase PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF07690 (2/4) Major Facilitator Superfamily PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_3769	240.97 +- 100.44	3	0	3	0	0.02 +- 0.02	3	6 PF12697 (3/3) Alpha/beta hydrolase family PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (3/3) Prolyl oligopeptidase family PF00313 (3/3) 'Cold-shock' DNA-binding domain PF00196 (3/3) Bacterial regulatory proteins, luxR family PF00069 (3/3) Protein kinase domain
jaccard_groups_2360	197.13 +- 83.31	2	0	0	0	0.02 +- 0.02	2	11 PF12833 (2/2) Helix-turn-helix domain PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01965 (2/2) DJ-1/PfpI family PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain TIGR03446 (1/2) mycothiol conjugate amidase Mca PF07859 (1/2) alpha/beta hydrolase fold PF02585 (1/2) GlcNAc-PI de-N-acetylase PF01494 (1/2) FAD binding domain
jaccard_groups_1785	273.52 +- 225.37	4	0	0	0	0.03 +- 0.07	4	3 PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01145 (4/4) SPFH domain / Band 7 family PF00877 (4/4) NlpC/P60 family
jaccard_groups_2807	154.14 +- 79.86	2	0	0	0	0.02 +- 0.03	2	9 PF13602 (2/2) Zinc-binding dehydrogenase PF13564 (2/2) DoxX-like family PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF00296 (2/2) Luciferase-like monooxygenase PF00106 (2/2) short chain dehydrogenase TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13460 (1/2) NAD(P)H-binding PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
jaccard_groups_2804	419.05 +- 139.95	3	0	0	0	0.01 +- 0.00	3	9 PF17853 (3/3) GGDEF-like domain PF13556 (3/3) PucR C-terminal helix-turn-helix domain PF12450 (3/3) von Willebrand factor PF12034 (3/3) Domain of unknown function (DUF3520) PF08592 (3/3) Domain of unknown function (DUF1772) PF03704 (3/3) Bacterial transcriptional activator domain PF00486 (3/3) Transcriptional regulatory protein, C terminal PF00092 (3/3) von Willebrand factor type A domain PF01590 (2/3) GAF domain
jaccard_groups_1424	383.25 +- 193.13	12	0	2	0	0.02 +- 0.06	12	5 PF07291 (12/12) Methylamine utilisation protein MauE PF00717 (12/12) Peptidase S24-like PF00005 (12/12) ABC transporter PF00578 (9/12) AhpC/TSA family PF10502 (6/12) Signal peptidase, peptidase S26
jaccard_groups_1397	799.92 +- 505.57	9	0	9	9	0.02 +- 0.07	9	11 TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (9/9) SagB-type dehydrogenase domain TIGR03604 (9/9) thiazole/oxazole-forming peptide maturase, SagD family component PF03412 (9/9) Peptidase C39 family PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (9/9) Nitroreductase family PF00664 (9/9) ABC transporter transmembrane region PF00005 (9/9) ABC transporter PF13575 (8/9) Domain of unknown function (DUF4135) PF00067 (8/9) Cytochrome P450 PF00364 (6/9) Biotin-requiring enzyme
jaccard_groups_5864	80.77 +- 3.37	2	0	0	0	0.06 +- 0.08	2	8 PF07690 (2/2) Major Facilitator Superfamily PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02515 (2/2) CoA-transferase family III PF00932 (2/2) Lamin Tail Domain PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_1544	41.61 +- 0.00	2	0	2	0	0.10 +- 0.09	2	4 PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I PF07690 (2/2) Major Facilitator Superfamily PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00067 (2/2) Cytochrome P450
jaccard_groups_719	282.54 +- 181.38	8	0	0	0	0.03 +- 0.05	8	6 PF07739 (8/8) TipAS antibiotic-recognition domain PF07228 (8/8) Stage II sporulation protein E (SpoIIE) PF13411 (7/8) MerR HTH family regulatory protein PF07690 (6/8) Major Facilitator Superfamily PF01551 (6/8) Peptidase family M23 PF00291 (6/8) Pyridoxal-phosphate dependent enzyme
jaccard_groups_8	552.00 +- 588.46	44	13	29	31	0.03 +- 0.05	31	6 PF00005 (44/44) ABC transporter PF00664 (41/44) ABC transporter transmembrane region PF00069 (38/44) Protein kinase domain PF05147 (30/44) Lanthionine synthetase C-like protein PF00326 (25/44) Prolyl oligopeptidase family PF04672 (23/44) S-adenosyl methyltransferase
jaccard_groups_9	133.85 +- 102.99	5	0	2	2	0.03 +- 0.04	5	1 PF00069 (5/5) Protein kinase domain
jaccard_groups_4	163.62 +- 122.15	7	1	1	0	0.04 +- 0.05	6	1 PF07690 (7/7) Major Facilitator Superfamily
jaccard_groups_5	171.61 +- 154.50	3	0	1	0	0.07 +- 0.12	3	3 PF08281 (3/3) Sigma-70, region 4 PF04542 (3/3) Sigma-70 region 2 TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family
jaccard_groups_2	376.95 +- 80.35	5	0	0	1	0.01 +- 0.00	5	1 PF00440 (5/5) Bacterial regulatory proteins, tetR family
jaccard_groups_3	243.73 +- 166.49	19	0	1	0	0.03 +- 0.08	19	3 PF07730 (19/19) Histidine kinase PF00196 (19/19) Bacterial regulatory proteins, luxR family PF00072 (19/19) Response regulator receiver domain
jaccard_groups_3864	150.05 +- 8.21	2	0	0	0	0.09 +- 0.23	2	24 TIGR03144 (2/2) cytochrome c-type biogenesis protein CcsB TIGR01525 (2/2) heavy metal translocating P-type ATPase TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13462 (2/2) Thioredoxin PF07884 (2/2) Vitamin K epoxide reductase family PF07690 (2/2) Major Facilitator Superfamily PF05140 (2/2) ResB-like family PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region PF01758 (2/2) Sodium Bile acid symporter family PF01578 (2/2) Cytochrome C assembly protein PF01545 (2/2) Cation efflux family PF01252 (2/2) Signal peptidase (SPase) II PF01022 (2/2) Bacterial regulatory protein, arsR family PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00578 (2/2) AhpC/TSA family PF00122 (2/2) E1-E2 ATPase TIGR01573 (1/2) CRISPR-associated endonuclease Cas2 TIGR00546 (1/2) apolipoprotein N-acyltransferase PF13411 (1/2) MerR HTH family regulatory protein PF12833 (1/2) Helix-turn-helix domain PF10825 (1/2) Protein of unknown function (DUF2752) PF09827 (1/2) CRISPR associated protein Cas2 PF02630 (1/2) SCO1/SenC PF00795 (1/2) Carbon-nitrogen hydrolase
jaccard_groups_2565	345.37 +- 304.63	2	0	0	0	0.02 +- 0.03	2	6 PF00082 (2/2) Subtilase family PF13620 (1/2) Carboxypeptidase regulatory-like domain PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PF13191 (1/2) AAA ATPase domain PF04978 (1/2) Protein of unknown function (DUF664) PF03704 (1/2) Bacterial transcriptional activator domain
jaccard_groups_293	149.38 +- 100.19	8	0	0	0	0.02 +- 0.02	8	4 PF14759 (7/8) Reductase C-terminal PF13370 (7/8) 4Fe-4S single cluster domain of Ferredoxin I PF07992 (7/8) Pyridine nucleotide-disulphide oxidoreductase PF00903 (5/8) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_5605	705.83 +- 204.17	2	0	0	0	0.01 +- 0.01	2	7 PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain PF17754 (2/2) MftR C-terminal domain PF13460 (2/2) NAD(P)H-binding PF04075 (2/2) F420H(2)-dependent quinone reductase PF01418 (2/2) Helix-turn-helix domain, rpiR family PF01380 (2/2) SIS domain PF00440 (2/2) Bacterial regulatory proteins, tetR family
jaccard_groups_69	42.23 +- 13.81	3	0	1	0	0.06 +- 0.04	3	2 PF00248 (3/3) Aldo/keto reductase family PF08007 (2/3) Cupin superfamily protein
jaccard_groups_1160	605.32 +- 462.85	23	0	23	0	0.07 +- 0.11	23	23 TIGR01733 (23/23) amino acid adenylation domain PF13193 (23/23) AMP-binding enzyme C-terminal domain PF10862 (23/23) FcoT-like thioesterase domain PF08545 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (23/23) Male sterility protein PF07690 (23/23) Major Facilitator Superfamily PF05118 (23/23) Aspartyl/Asparaginyl beta-hydroxylase PF02668 (23/23) Taurine catabolism dioxygenase TauD, TfdA family PF00668 (23/23) Condensation domain PF00550 (23/23) Phosphopantetheine attachment site PF00501 (23/23) AMP-binding enzyme TIGR01746 (22/23) thioester reductase domain TIGR01525 (22/23) heavy metal translocating P-type ATPase TIGR00747 (22/23) 3-oxoacyl-[acyl-carrier-protein] synthase III PF04314 (22/23) Copper chaperone PCu(A)C PF00702 (22/23) haloacid dehalogenase-like hydrolase PF00403 (22/23) Heavy-metal-associated domain PF00122 (22/23) E1-E2 ATPase PF01497 (21/23) Periplasmic binding protein PF01032 (21/23) FecCD transport family PF00005 (21/23) ABC transporter PF01965 (19/23) DJ-1/PfpI family
jaccard_groups_22	134.76 +- 86.38	2	0	0	0	0.04 +- 0.07	2	3 PF12802 (2/2) MarR family PF01965 (2/2) DJ-1/PfpI family PF00069 (2/2) Protein kinase domain
jaccard_groups_4291	227.25 +- 162.75	2	0	0	0	0.03 +- 0.05	2	7 TIGR01840 (2/2) esterase, PHB depolymerase family PF10503 (2/2) Esterase PHB depolymerase PF08223 (2/2) PaaX-like protein C-terminal domain PF07848 (2/2) PaaX-like protein PF00652 (2/2) Ricin-type beta-trefoil lectin domain PF00553 (2/2) Cellulose binding domain PF00331 (2/2) Glycosyl hydrolase family 10
jaccard_groups_199	250.40 +- 9.60	2	0	0	0	0.02 +- 0.02	2	4 PF13365 (2/2) Trypsin-like peptidase domain PF00400 (2/2) WD domain, G-beta repeat PF00248 (2/2) Aldo/keto reductase family PF07721 (1/2) Tetratricopeptide repeat
jaccard_groups_222	1424.71 +- 886.93	4	0	0	0	0.02 +- 0.05	4	9 PF07811 (4/4) TadE-like protein PF00482 (4/4) Type II secretion system (T2SS), protein F PF00437 (4/4) Type II/IV secretion system protein PF13400 (3/4) Putative Flp pilus-assembly TadE/G-like PF08666 (3/4) SAF domain PF01476 (3/4) LysM domain PF14081 (2/4) Domain of unknown function (DUF4262) PF03704 (2/4) Bacterial transcriptional activator domain PF01381 (2/4) Helix-turn-helix
jaccard_groups_2414	122.10 +- 43.38	4	0	0	0	0.05 +- 0.04	4	12 TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01891 (4/4) amidohydrolase TIGR00843 (4/4) benzoate transporter PF13454 (4/4) FAD-NAD(P)-binding PF13424 (4/4) Tetratricopeptide repeat PF03594 (4/4) Benzoate membrane transport protein PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family PF01546 (4/4) Peptidase family M20/M25/M40 PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme PF00931 (4/4) NB-ARC domain PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
jaccard_groups_5043	760.47 +- 374.44	3	0	0	0	0.04 +- 0.12	3	26 TIGR03567 (3/3) FMN reductase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain PF14559 (3/3) Tetratricopeptide repeat PF13535 (3/3) ATP-grasp domain PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring) PF13432 (3/3) Tetratricopeptide repeat PF13424 (3/3) Tetratricopeptide repeat PF07690 (3/3) Major Facilitator Superfamily PF03358 (3/3) NADPH-dependent FMN reductase PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF01613 (3/3) Flavin reductase like domain PF00326 (3/3) Prolyl oligopeptidase family PF00294 (3/3) pfkB family carbohydrate kinase TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family PF09334 (2/3) tRNA synthetases class I (M) PF08281 (2/3) Sigma-70, region 4 PF07883 (2/3) Cupin domain PF04542 (2/3) Sigma-70 region 2 PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02142 (2/3) MGS-like domain PF01808 (2/3) AICARFT/IMPCHase bienzyme PF00709 (2/3) Adenylosuccinate synthetase PF00355 (2/3) Rieske [2Fe-2S] domain PF00202 (2/3) Aminotransferase class-III
jaccard_groups_60	278.98 +- 192.79	15	1	0	1	0.02 +- 0.04	14	1 PF00082 (15/15) Subtilase family
jaccard_groups_5049	388.00 +- 128.00	2	0	0	0	0.01 +- 0.00	2	6 PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07729 (2/2) FCD domain PF02627 (2/2) Carboxymuconolactone decarboxylase family PF00753 (2/2) Metallo-beta-lactamase superfamily PF00561 (2/2) alpha/beta hydrolase fold PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_25	108.15 +- 115.79	8	0	0	0	0.06 +- 0.06	8	5 PF05331 (8/8) Protein of unknown function (DUF742) PF03259 (8/8) Roadblock/LC7 domain PF03029 (8/8) Conserved hypothetical ATP binding protein PF00067 (8/8) Cytochrome P450 PF04149 (6/8) Domain of unknown function (DUF397)
jaccard_groups_26	115.49 +- 100.95	3	0	0	0	0.04 +- 0.04	3	1 PF00293 (3/3) NUDIX domain
jaccard_groups_21	325.60 +- 323.07	3	0	0	0	0.03 +- 0.08	3	6 TIGR03696 (3/3) RHS repeat-associated core domain TIGR01643 (2/3) YD repeat (two copies) TIGR01443 (2/3) intein C-terminal splicing region PF13385 (2/3) Concanavalin A-like lectin/glucanases superfamily PF07591 (2/3) Pretoxin HINT domain PF05593 (2/3) RHS Repeat
jaccard_groups_23	135.79 +- 170.09	4	0	0	0	0.07 +- 0.12	4	4 PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain PF07690 (3/4) Major Facilitator Superfamily
jaccard_groups_4226	444.94 +- 356.18	4	0	0	0	0.03 +- 0.04	4	6 PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF03992 (4/4) Antibiotic biosynthesis monooxygenase PF00664 (4/4) ABC transporter transmembrane region PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00248 (4/4) Aldo/keto reductase family PF00005 (4/4) ABC transporter
jaccard_groups_3896	821.14 +- 717.35	4	0	0	0	0.05 +- 0.15	4	21 TIGR01928 (4/4) o-succinylbenzoate synthase TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF17676 (4/4) LD-carboxypeptidase C-terminal domain PF13378 (4/4) Enolase C-terminal domain-like PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02016 (4/4) LD-carboxypeptidase N-terminal domain PF01546 (4/4) Peptidase family M20/M25/M40 PF01380 (4/4) SIS domain PF00528 (4/4) Binding-protein-dependent transport system inner membrane component PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle PF00005 (4/4) ABC transporter PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase PF12831 (3/4) FAD dependent oxidoreductase PF07883 (3/4) Cupin domain PF07690 (3/4) Major Facilitator Superfamily PF02515 (3/4) CoA-transferase family III PF01381 (3/4) Helix-turn-helix PF00701 (3/4) Dihydrodipicolinate synthetase family PF00378 (3/4) Enoyl-CoA hydratase/isomerase PF00171 (3/4) Aldehyde dehydrogenase family
jaccard_groups_29	162.56 +- 163.90	7	0	0	0	0.03 +- 0.04	7	1 PF00583 (7/7) Acetyltransferase (GNAT) family
jaccard_groups_349	258.00 +- 0.00	2	0	0	0	0.01 +- 0.01	2	5 PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01522 (1/2) Polysaccharide deacetylase PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase PF01145 (1/2) SPFH domain / Band 7 family PF00877 (1/2) NlpC/P60 family
jaccard_groups_178	362.00 +- 154.00	2	0	2	0	0.01 +- 0.01	2	2 PF08291 (2/2) Peptidase M15 PF01471 (2/2) Putative peptidoglycan binding domain
jaccard_groups_3030	124.21 +- 42.94	2	0	2	0	0.06 +- 0.06	2	13 PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01756 (2/2) Acyl-CoA oxidase PF00550 (2/2) Phosphopantetheine attachment site PF00294 (2/2) pfkB family carbohydrate kinase PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF12840 (1/2) Helix-turn-helix domain PF10400 (1/2) Virulence activator alpha C-term PF03551 (1/2) Transcriptional regulator PadR-like family PF01497 (1/2) Periplasmic binding protein PF00005 (1/2) ABC transporter
jaccard_groups_1341	234.18 +- 83.20	3	0	0	0	0.08 +- 0.09	3	11 TIGR01234 (3/3) ribulokinase PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like PF11762 (3/3) L-arabinose isomerase C-terminal domain PF06964 (3/3) Alpha-L-arabinofuranosidase C-terminal domain PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain PF02610 (3/3) L-arabinose isomerase PF01547 (3/3) Bacterial extracellular solute-binding protein PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain PF18029 (2/3) Glyoxalase-like domain
jaccard_groups_1268	97.17 +- 73.63	3	0	0	0	0.05 +- 0.04	3	6 PF00106 (3/3) short chain dehydrogenase PF12833 (2/3) Helix-turn-helix domain PF12625 (2/3) Arabinose-binding domain of AraC transcription regulator, N-term PF02416 (2/3) mttA/Hcf106 family PF00743 (2/3) Flavin-binding monooxygenase-like PF00171 (2/3) Aldehyde dehydrogenase family
jaccard_groups_5131	516.00 +- 0.00	2	0	2	0	0.01 +- 0.00	2	4 PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent PF03781 (2/2) Sulfatase-modifying factor enzyme 1 PF02450 (2/2) Lecithin:cholesterol acyltransferase PF00400 (2/2) WD domain, G-beta repeat
jaccard_groups_6119	292.50 +- 0.00	2	0	0	0	0.01 +- 0.00	2	3 PF01323 (2/2) DSBA-like thioredoxin domain PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00082 (2/2) Subtilase family
jaccard_groups_3009	387.00 +- 271.72	2	0	0	2	0.04 +- 0.03	2	29 TIGR04050 (2/2) AIR synthase-related protein, MSMEG_0567 C-terminal family TIGR04047 (2/2) glycosyltransferase, MSMEG_0565 family TIGR04046 (2/2) flavin-dependent oxidoreductase, MSMEG_0569 family TIGR04045 (2/2) putative N-acetyltransferase, MSMEG_0567 N-terminal domain family TIGR04044 (2/2) MSMEG_0572 family protein TIGR04043 (2/2) radical SAM protein, MSMEG_0568 family TIGR04042 (2/2) MSMEG_0570 family protein PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF13439 (2/2) Glycosyltransferase Family 4 PF04909 (2/2) Amidohydrolase PF04055 (2/2) Radical SAM superfamily PF02769 (2/2) AIR synthase related protein, C-terminal domain PF02635 (2/2) DsrE/DsrF-like family PF00795 (2/2) Carbon-nitrogen hydrolase PF00586 (2/2) AIR synthase related protein, N-terminal domain PF00583 (2/2) Acetyltransferase (GNAT) family PF00534 (2/2) Glycosyl transferases group 1 TIGR01910 (1/2) peptidase, ArgE/DapE family PF18029 (1/2) Glyoxalase-like domain PF16990 (1/2) Carbohydrate binding module (family 35) PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain PF13377 (1/2) Periplasmic binding protein-like domain PF03422 (1/2) Carbohydrate binding module (family 6) PF02065 (1/2) Melibiase PF01547 (1/2) Bacterial extracellular solute-binding protein PF01546 (1/2) Peptidase family M20/M25/M40 PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_3413	260.72 +- 115.49	7	0	0	0	0.01 +- 0.01	7	5 TIGR02532 (7/7) prepilin-type N-terminal cleavage/methylation domain PF07963 (7/7) Prokaryotic N-terminal methylation motif PF06750 (7/7) Bacterial Peptidase A24 N-terminal domain PF03551 (7/7) Transcriptional regulator PadR-like family PF01478 (7/7) Type IV leader peptidase family
jaccard_groups_4315	1556.00 +- 516.03	4	0	0	0	0.01 +- 0.00	4	7 PF08386 (4/4) TAP-like protein PF07702 (4/4) UTRA domain PF01380 (4/4) SIS domain PF00561 (4/4) alpha/beta hydrolase fold PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00294 (4/4) pfkB family carbohydrate kinase PF00196 (4/4) Bacterial regulatory proteins, luxR family
jaccard_groups_3003	1355.01 +- 1011.49	7	0	6	0	0.03 +- 0.08	7	10 PF13622 (7/7) Thioesterase-like superfamily PF00550 (7/7) Phosphopantetheine attachment site PF00501 (7/7) AMP-binding enzyme PF00487 (7/7) Fatty acid desaturase PF00301 (7/7) Rubredoxin PF00067 (7/7) Cytochrome P450 PF07690 (6/7) Major Facilitator Superfamily PF12146 (5/7) Serine aminopeptidase, S33 PF12679 (4/7) ABC-2 family transporter protein PF00005 (4/7) ABC transporter
jaccard_groups_6202	571.90 +- 331.10	2	0	0	0	0.02 +- 0.03	2	9 TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083 PF17964 (2/2) Bacterial Ig domain PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF07702 (2/2) UTRA domain PF07398 (2/2) MDMPI C-terminal domain PF03734 (2/2) L,D-transpeptidase catalytic domain PF01381 (2/2) Helix-turn-helix PF00931 (2/2) NB-ARC domain PF00392 (2/2) Bacterial regulatory proteins, gntR family
jaccard_groups_537	40.72 +- 12.05	2	0	0	0	0.06 +- 0.14	2	6 PF13641 (2/2) Glycosyltransferase like family 2 PF01757 (2/2) Acyltransferase family PF01522 (2/2) Polysaccharide deacetylase PF18616 (1/2) CDI immunity proteins PF03466 (1/2) LysR substrate binding domain PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_3091	1255.97 +- 999.97	4	0	4	0	0.03 +- 0.06	4	33 TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (4/4) amino acid adenylation domain TIGR00976 (4/4) hydrolase CocE/NonD family protein PF16197 (4/4) Ketoacyl-synthetase C-terminal extension PF13193 (4/4) AMP-binding enzyme C-terminal domain PF13187 (4/4) 4Fe-4S dicluster domain PF08659 (4/4) KR domain PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07690 (4/4) Major Facilitator Superfamily PF07228 (4/4) Stage II sporulation protein E (SpoIIE) PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family) PF01070 (4/4) FMN-dependent dehydrogenase PF00698 (4/4) Acyl transferase domain PF00668 (4/4) Condensation domain PF00583 (4/4) Acetyltransferase (GNAT) family PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00296 (4/4) Luciferase-like monooxygenase PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00202 (4/4) Aminotransferase class-III PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain PF13459 (3/4) 4Fe-4S single cluster domain PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF09335 (3/4) SNARE associated Golgi protein PF07730 (3/4) Histidine kinase PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00196 (3/4) Bacterial regulatory proteins, luxR family PF00072 (3/4) Response regulator receiver domain
jaccard_groups_533	69.67 +- 7.31	3	0	0	0	0.03 +- 0.03	3	2 PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase PF00067 (2/3) Cytochrome P450
jaccard_groups_4218	516.00 +- 258.00	2	0	0	0	0.02 +- 0.03	2	3 PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase PF00248 (2/2) Aldo/keto reductase family
jaccard_groups_538	717.07 +- 434.19	8	0	0	0	0.03 +- 0.03	8	5 PF13416 (8/8) Bacterial extracellular solute-binding protein PF08402 (8/8) TOBE domain PF00528 (8/8) Binding-protein-dependent transport system inner membrane component PF00005 (8/8) ABC transporter PF00962 (4/8) Adenosine/AMP deaminase
jaccard_groups_17	103.93 +- 69.03	9	0	0	1	0.04 +- 0.05	9	2 PF07702 (9/9) UTRA domain PF00392 (9/9) Bacterial regulatory proteins, gntR family
jaccard_groups_459	261.23 +- 64.11	5	0	0	0	0.01 +- 0.01	5	6 PF13459 (5/5) 4Fe-4S single cluster domain PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF08386 (5/5) TAP-like protein PF03640 (5/5) Secreted repeat of unknown function PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00561 (5/5) alpha/beta hydrolase fold
jaccard_groups_755	275.25 +- 17.25	2	0	1	0	0.01 +- 0.00	2	10 TIGR00231 (2/2) small GTP-binding protein domain PF14492 (2/2) Elongation Factor G, domain II PF03764 (2/2) Elongation factor G, domain IV PF00679 (2/2) Elongation factor G C-terminus PF00009 (2/2) Elongation factor Tu GTP binding domain PF16864 (1/2) Dimerisation domain PF13404 (1/2) AsnC-type helix-turn-helix domain PF01494 (1/2) FAD binding domain PF00891 (1/2) O-methyltransferase domain PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_1869	365.99 +- 130.08	14	0	8	0	0.06 +- 0.03	14	18 PF13561 (14/14) Enoyl-(Acyl carrier protein) reductase PF08545 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02801 (14/14) Beta-ketoacyl synthase, C-terminal domain PF00378 (14/14) Enoyl-CoA hydratase/isomerase PF00109 (14/14) Beta-ketoacyl synthase, N-terminal domain PF00106 (14/14) short chain dehydrogenase TIGR00976 (13/14) hydrolase CocE/NonD family protein PF13193 (13/14) AMP-binding enzyme C-terminal domain PF08530 (13/14) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (13/14) X-Pro dipeptidyl-peptidase (S15 family) PF01144 (13/14) Coenzyme A transferase PF00501 (13/14) AMP-binding enzyme PF00196 (13/14) Bacterial regulatory proteins, luxR family PF00005 (13/14) ABC transporter PF04909 (12/14) Amidohydrolase PF12679 (10/14) ABC-2 family transporter protein PF12697 (9/14) Alpha/beta hydrolase family
jaccard_groups_128	110.12 +- 103.02	10	0	2	0	0.04 +- 0.05	10	1 PF01872 (10/10) RibD C-terminal domain
jaccard_groups_127	154.80 +- 0.00	2	0	0	0	0.02 +- 0.01	2	5 TIGR01549 (2/2) HAD hydrolase, family IA, variant 1 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF09130 (2/2) Domain of unknown function (DUF1932) PF02384 (2/2) N-6 DNA Methylase PF01341 (2/2) Glycosyl hydrolases family 6
jaccard_groups_2734	595.57 +- 149.62	4	0	4	0	0.01 +- 0.00	4	17 TIGR01509 (4/4) HAD hydrolase, family IA, variant 3 PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1 PF16864 (4/4) Dimerisation domain PF14015 (4/4) Protein of unknown function (DUF4231) PF13692 (4/4) Glycosyl transferases group 1 PF13676 (4/4) TIR domain PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13419 (4/4) Haloacid dehalogenase-like hydrolase PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase PF12464 (4/4) Maltose acetyltransferase PF11941 (4/4) Domain of unknown function (DUF3459) PF07728 (4/4) AAA domain (dynein-related subfamily) PF05729 (4/4) NACHT domain PF01636 (4/4) Phosphotransferase enzyme family PF00891 (4/4) O-methyltransferase domain PF00202 (4/4) Aminotransferase class-III PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
jaccard_groups_2138	57.64 +- 2.36	2	0	0	0	0.07 +- 0.09	2	4 PF04203 (2/2) Sortase domain PF04149 (2/2) Domain of unknown function (DUF397) PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00583 (2/2) Acetyltransferase (GNAT) family
jaccard_groups_122	269.82 +- 196.36	3	0	0	0	0.04 +- 0.06	3	2 PF11706 (3/3) CGNR zinc finger PF07336 (3/3) Putative stress-induced transcription regulator
jaccard_groups_4359	73.12 +- 24.38	2	0	0	0	0.03 +- 0.02	2	3 PF06912 (2/2) Protein of unknown function (DUF1275) PF02308 (2/2) MgtC family PF01566 (2/2) Natural resistance-associated macrophage protein
jaccard_groups_1295	60.20 +- 25.80	2	0	0	0	0.03 +- 0.04	2	3 PF04231 (2/2) Endonuclease I PF11239 (1/2) Protein of unknown function (DUF3040) PF10706 (1/2) Aminoglycoside-2''-adenylyltransferase
jaccard_groups_2927	622.29 +- 125.90	3	0	3	0	0.01 +- 0.02	3	9 TIGR01250 (3/3) proline-specific peptidase PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I PF06368 (3/3) Methylaspartate mutase E chain (MutE) PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain PF02310 (3/3) B12 binding domain PF00561 (3/3) alpha/beta hydrolase fold PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00067 (3/3) Cytochrome P450
jaccard_groups_1740	228.06 +- 94.91	4	0	0	0	0.06 +- 0.09	4	14 PF18565 (4/4) Glycoside hydrolase family 2 C-terminal domain 5 PF16355 (4/4) Domain of unknown function (DUF4982) PF14310 (4/4) Fibronectin type III-like domain PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain PF00703 (4/4) Glycosyl hydrolases family 2 PF17390 (3/4) Bacterial alpha-L-rhamnosidase C-terminal domain PF17389 (3/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase PF08531 (3/4) Alpha-L-rhamnosidase N-terminal domain PF07859 (3/4) alpha/beta hydrolase fold PF05592 (3/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain
jaccard_groups_1465	83.73 +- 28.80	3	0	0	0	0.05 +- 0.05	3	5 PF07690 (3/3) Major Facilitator Superfamily PF05893 (3/3) Acyl-CoA reductase (LuxC) PF04443 (3/3) Acyl-protein synthetase, LuxE PF00583 (3/3) Acetyltransferase (GNAT) family PF00501 (3/3) AMP-binding enzyme
jaccard_groups_984	274.59 +- 266.03	15	0	0	14	0.03 +- 0.05	15	3 PF07690 (15/15) Major Facilitator Superfamily PF04055 (14/15) Radical SAM superfamily PF13649 (11/15) Methyltransferase domain
jaccard_groups_3631	516.88 +- 343.12	2	0	2	0	0.04 +- 0.11	2	19 TIGR01733 (2/2) amino acid adenylation domain TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720 TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit TIGR00169 (2/2) 3-isopropylmalate dehydrogenase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF11806 (2/2) Domain of unknown function (DUF3327) PF08242 (2/2) Methyltransferase domain PF03621 (2/2) MbtH-like protein PF00756 (2/2) Putative esterase PF00694 (2/2) Aconitase C-terminal domain PF00682 (2/2) HMGL-like PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00330 (2/2) Aconitase family (aconitate hydratase) PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase PF00155 (2/2) Aminotransferase class I and II
jaccard_groups_150	137.60 +- 34.40	2	0	0	0	0.02 +- 0.01	2	3 PF04672 (2/2) S-adenosyl methyltransferase TIGR03296 (1/2) M6 family metalloprotease domain PF13649 (1/2) Methyltransferase domain
jaccard_groups_5491	961.71 +- 70.29	2	0	2	0	0.01 +- 0.00	2	8 PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF08386 (2/2) TAP-like protein PF07732 (2/2) Multicopper oxidase PF07731 (2/2) Multicopper oxidase PF07676 (2/2) WD40-like Beta Propeller Repeat PF01979 (2/2) Amidohydrolase family PF00561 (2/2) alpha/beta hydrolase fold PF00394 (2/2) Multicopper oxidase
jaccard_groups_2218	454.73 +- 318.28	6	0	0	0	0.05 +- 0.08	6	7 PF13411 (6/6) MerR HTH family regulatory protein PF07739 (6/6) TipAS antibiotic-recognition domain PF03033 (6/6) Glycosyltransferase family 28 N-terminal domain PF01551 (6/6) Peptidase family M23 PF00392 (6/6) Bacterial regulatory proteins, gntR family PF00005 (6/6) ABC transporter PF12679 (5/6) ABC-2 family transporter protein
jaccard_groups_2357	138.29 +- 11.26	2	0	2	0	0.06 +- 0.16	2	22 TIGR02412 (2/2) aminopeptidase N TIGR01686 (2/2) FkbH domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring) PF11838 (2/2) ERAP1-like C-terminal domain PF09334 (2/2) tRNA synthetases class I (M) PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07883 (2/2) Cupin domain PF07690 (2/2) Major Facilitator Superfamily PF02274 (2/2) Amidinotransferase PF01433 (2/2) Peptidase family M1 domain PF01266 (2/2) FAD dependent oxidoreductase PF00999 (2/2) Sodium/hydrogen exchanger family PF00550 (2/2) Phosphopantetheine attachment site PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF17900 (1/2) Peptidase M1 N-terminal domain PF03466 (1/2) LysR substrate binding domain PF02195 (1/2) ParB-like nuclease domain PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_5496	155.40 +- 85.40	2	0	0	0	0.04 +- 0.04	2	6 TIGR03921 (2/2) type VII secretion-associated serine protease mycosin PF07729 (2/2) FCD domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00293 (2/2) NUDIX domain PF00221 (2/2) Aromatic amino acid lyase PF00082 (2/2) Subtilase family
jaccard_groups_2608	1607.67 +- 212.33	2	0	2	0	0.01 +- 0.00	2	31 TIGR01733 (2/2) amino acid adenylation domain TIGR01686 (2/2) FkbH domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF13649 (2/2) Methyltransferase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12844 (2/2) Helix-turn-helix domain PF08892 (2/2) YqcI/YcgG family PF07690 (2/2) Major Facilitator Superfamily PF03486 (2/2) HI0933-like protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02780 (2/2) Transketolase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF01636 (2/2) Phosphotransferase enzyme family PF01409 (2/2) tRNA synthetases class II core domain (F) PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF17874 (1/2) MalT-like TPR region
jaccard_groups_393	101.79 +- 64.37	20	0	0	0	0.03 +- 0.02	20	3 PF12833 (20/20) Helix-turn-helix domain PF02311 (20/20) AraC-like ligand binding domain PF00150 (19/20) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_2851	45.39 +- 2.39	2	0	2	0	0.04 +- 0.04	2	7 PF12697 (2/2) Alpha/beta hydrolase family PF07063 (2/2) Domain of unknown function (DUF1338) PF01266 (2/2) FAD dependent oxidoreductase PF00171 (2/2) Aldehyde dehydrogenase family PF17874 (1/2) MalT-like TPR region PF13560 (1/2) Helix-turn-helix domain PF13432 (1/2) Tetratricopeptide repeat
jaccard_groups_2323	87.16 +- 61.05	3	0	0	0	0.04 +- 0.08	3	4 PF03965 (3/3) Penicillinase repressor PF01435 (3/3) Peptidase family M48 PF00403 (3/3) Heavy-metal-associated domain PF00877 (2/3) NlpC/P60 family
jaccard_groups_2321	388.80 +- 1.47	5	0	0	0	0.01 +- 0.00	5	3 PF07690 (5/5) Major Facilitator Superfamily PF01425 (5/5) Amidase PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
jaccard_groups_1046	301.58 +- 214.44	4	0	4	4	0.07 +- 0.15	4	13 TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term PF05147 (4/4) Lanthionine synthetase C-like protein PF04738 (4/4) Lantibiotic dehydratase, N terminus PF00296 (4/4) Luciferase-like monooxygenase PF00005 (4/4) ABC transporter TIGR03558 (2/4) luciferase family oxidoreductase, group 1 PF13649 (2/4) Methyltransferase domain PF01292 (2/4) Prokaryotic cytochrome b561 PF00196 (2/4) Bacterial regulatory proteins, luxR family PF00188 (2/4) Cysteine-rich secretory protein family PF00174 (2/4) Oxidoreductase molybdopterin binding domain PF00072 (2/4) Response regulator receiver domain
jaccard_groups_1045	608.93 +- 519.61	5	0	4	1	0.03 +- 0.05	5	11 TIGR03945 (5/5) 2,3-diaminopropionate biosynthesis protein SbnA TIGR01733 (5/5) amino acid adenylation domain PF13193 (5/5) AMP-binding enzyme C-terminal domain PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family PF00550 (5/5) Phosphopantetheine attachment site PF00501 (5/5) AMP-binding enzyme PF00291 (5/5) Pyridoxal-phosphate dependent enzyme TIGR03944 (4/5) 2,3-diaminopropionate biosynthesis protein SbnB PF00975 (4/5) Thioesterase domain PF02668 (3/5) Taurine catabolism dioxygenase TauD, TfdA family PF00668 (3/5) Condensation domain
jaccard_groups_628	28.77 +- 5.25	10	0	3	0	0.07 +- 0.09	10	6 PF13244 (10/10) Domain of unknown function (DUF4040) PF04066 (10/10) Multiple resistance and pH regulation protein F (MrpF / PhaF) PF04039 (10/10) Domain related to MnhB subunit of Na+/H+ antiporter PF00420 (10/10) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PF00361 (10/10) Proton-conducting membrane transporter PF12840 (9/10) Helix-turn-helix domain
jaccard_groups_2516	118.50 +- 53.50	2	0	0	0	0.05 +- 0.07	2	14 PF13340 (2/2) Putative transposase of IS4/5 family (DUF4096) PF13338 (2/2) Transcriptional regulator, AbiEi antitoxin PF12770 (2/2) CHAT domain PF07510 (2/2) Protein of unknown function (DUF1524) PF03235 (2/2) Protein of unknown function DUF262 PF01609 (2/2) Transposase DDE domain PF01035 (2/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain PF17908 (1/2) APAF-1 helical domain PF13586 (1/2) Transposase DDE domain PF04555 (1/2) Restriction endonuclease XhoI PF01937 (1/2) Protein of unknown function DUF89 PF01636 (1/2) Phosphotransferase enzyme family PF00931 (1/2) NB-ARC domain PF00400 (1/2) WD domain, G-beta repeat
jaccard_groups_302	291.55 +- 224.45	2	0	0	0	0.03 +- 0.06	2	1 PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
jaccard_groups_300	2363.38 +- 2722.61	59	9	49	59	0.03 +- 0.08	50	9 TIGR03882 (59/59) bacteriocin biosynthesis cyclodehydratase domain PF02624 (59/59) YcaO cyclodehydratase, ATP-ad Mg2+-binding TIGR03604 (58/59) thiazole/oxazole-forming peptide maturase, SagD family component PF00881 (58/59) Nitroreductase family PF14028 (57/59) Lantibiotic biosynthesis dehydratase C-term PF00005 (41/59) ABC transporter PF04738 (40/59) Lantibiotic dehydratase, N terminus PF01061 (33/59) ABC-2 type transporter TIGR03605 (30/59) SagB-type dehydrogenase domain
jaccard_groups_78	154.21 +- 58.34	3	0	0	0	0.07 +- 0.05	3	5 PF13416 (3/3) Bacterial extracellular solute-binding protein PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF17831 (2/3) Pyruvate dehydrogenase E1 component middle domain PF00456 (2/3) Transketolase, thiamine diphosphate binding domain PF00266 (2/3) Aminotransferase class-V
jaccard_groups_5672	246.49 +- 143.51	2	0	2	2	0.04 +- 0.15	2	8 PF11259 (2/2) Protein of unknown function (DUF3060) PF04055 (2/2) Radical SAM superfamily PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF02310 (2/2) B12 binding domain PF01522 (2/2) Polysaccharide deacetylase PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00072 (2/2) Response regulator receiver domain PF00583 (1/2) Acetyltransferase (GNAT) family
jaccard_groups_73	411.67 +- 186.38	3	0	2	1	0.03 +- 0.03	3	3 PF01061 (3/3) ABC-2 type transporter PF00005 (3/3) ABC transporter PF00082 (2/3) Subtilase family
jaccard_groups_4270	122.11 +- 15.00	3	0	1	0	0.08 +- 0.21	3	9 PF13191 (3/3) AAA ATPase domain PF10502 (3/3) Signal peptidase, peptidase S26 PF07291 (3/3) Methylamine utilisation protein MauE PF02254 (3/3) TrkA-N domain PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase PF00717 (3/3) Peptidase S24-like PF00664 (3/3) ABC transporter transmembrane region PF00005 (3/3) ABC transporter PF13181 (2/3) Tetratricopeptide repeat
jaccard_groups_76	709.50 +- 322.50	2	0	0	0	0.01 +- 0.00	2	7 PF09339 (2/2) IclR helix-turn-helix domain PF01614 (2/2) Bacterial transcriptional regulator TIGR03296 (1/2) M6 family metalloprotease domain PF07158 (1/2) Dicarboxylate carrier protein MatC N-terminus PF01471 (1/2) Putative peptidoglycan binding domain PF00939 (1/2) Sodium:sulfate symporter transmembrane region PF00293 (1/2) NUDIX domain
jaccard_groups_4274	118.18 +- 51.61	4	0	0	0	0.04 +- 0.03	4	9 PF13377 (4/4) Periplasmic binding protein-like domain PF08124 (4/4) Polysaccharide lyase family 8, N terminal alpha-helical domain PF02884 (4/4) Polysaccharide lyase family 8, C-terminal beta-sandwich domain PF02278 (4/4) Polysaccharide lyase family 8, super-sandwich domain PF00356 (4/4) Bacterial regulatory proteins, lacI family PF17291 (3/4) N-terminal domain of M60-like peptidases PF13402 (3/4) Peptidase M60, enhancin and enhancin-like PF10022 (3/4) Uncharacterized protein conserved in bacteria (DUF2264) PF02826 (3/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
jaccard_groups_4730	915.56 +- 502.62	2	0	0	0	0.01 +- 0.01	2	8 PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07722 (2/2) Peptidase C26 PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF00202 (2/2) Aminotransferase class-III PF00171 (2/2) Aldehyde dehydrogenase family PF00120 (2/2) Glutamine synthetase, catalytic domain PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_4301	275.37 +- 49.63	2	0	0	0	0.02 +- 0.02	2	8 TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16884 (2/2) N-terminal domain of oxidoreductase PF12146 (2/2) Serine aminopeptidase, S33 PF07690 (2/2) Major Facilitator Superfamily PF06441 (2/2) Epoxide hydrolase N terminus PF00561 (2/2) alpha/beta hydrolase fold PF00107 (2/2) Zinc-binding dehydrogenase PF00106 (2/2) short chain dehydrogenase
jaccard_groups_5373	133.61 +- 63.96	2	0	2	0	0.09 +- 0.20	2	22 TIGR01746 (2/2) thioester reductase domain TIGR01733 (2/2) amino acid adenylation domain PF16864 (2/2) Dimerisation domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07993 (2/2) Male sterility protein PF04389 (2/2) Peptidase family M28 PF03621 (2/2) MbtH-like protein PF00891 (2/2) O-methyltransferase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF13847 (1/2) Methyltransferase domain PF13459 (1/2) 4Fe-4S single cluster domain PF08241 (1/2) Methyltransferase domain PF08031 (1/2) Berberine and berberine like PF07690 (1/2) Major Facilitator Superfamily PF07366 (1/2) SnoaL-like polyketide cyclase PF06821 (1/2) Serine hydrolase PF01565 (1/2) FAD binding domain PF01494 (1/2) FAD binding domain PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase PF00067 (1/2) Cytochrome P450
jaccard_groups_4878	1332.86 +- 227.14	2	0	1	0	0.01 +- 0.01	2	11 TIGR01879 (2/2) amidase, hydantoinase/carbamoylase family TIGR01037 (2/2) dihydroorotate dehydrogenase family protein TIGR00857 (2/2) dihydroorotase, multifunctional complex type PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PF09084 (2/2) NMT1/THI5 like PF01979 (2/2) Amidohydrolase family PF01546 (2/2) Peptidase family M20/M25/M40 PF01180 (2/2) Dihydroorotate dehydrogenase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter PF00589 (1/2) Phage integrase family
jaccard_groups_1228	327.66 +- 69.66	2	0	0	0	0.02 +- 0.02	2	7 PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1) PF13407 (1/2) Periplasmic binding protein domain PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02653 (1/2) Branched-chain amino acid transport system / permease component PF00005 (1/2) ABC transporter
jaccard_groups_5078	303.16 +- 34.84	2	0	0	0	0.06 +- 0.10	2	19 TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily PF14310 (2/2) Fibronectin type III-like domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13529 (2/2) Peptidase_C39 like family PF12697 (2/2) Alpha/beta hydrolase family PF07729 (2/2) FCD domain PF06684 (2/2) Amino acid synthesis PF04545 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF04539 (2/2) Sigma-70 region 3 PF03547 (2/2) Membrane transport protein PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00296 (2/2) Luciferase-like monooxygenase PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_3743	233.66 +- 123.26	4	0	0	0	0.02 +- 0.03	4	6 PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain PF07690 (4/4) Major Facilitator Superfamily PF05922 (4/4) Peptidase inhibitor I9 PF00535 (4/4) Glycosyl transferase family 2 PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00082 (4/4) Subtilase family
jaccard_groups_1223	173.25 +- 198.69	8	0	4	0	0.05 +- 0.09	8	6 PF07992 (8/8) Pyridine nucleotide-disulphide oxidoreductase PF04324 (8/8) BFD-like [2Fe-2S] binding domain PF02782 (8/8) FGGY family of carbohydrate kinases, C-terminal domain PF01266 (8/8) FAD dependent oxidoreductase PF00370 (8/8) FGGY family of carbohydrate kinases, N-terminal domain PF00293 (5/8) NUDIX domain
jaccard_groups_5175	358.87 +- 76.47	3	0	3	0	0.03 +- 0.03	3	16 TIGR03396 (3/3) phospholipase C, phosphocholine-specific TIGR01258 (3/3) phosphoglycerate mutase 1 family TIGR01060 (3/3) phosphopyruvate hydratase PF11575 (3/3) FhuF 2Fe-2S C-terminal domain PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF05506 (3/3) Domain of unknown function (DUF756) PF04185 (3/3) Phosphoesterase family PF03965 (3/3) Penicillinase repressor PF03952 (3/3) Enolase, N-terminal domain PF03453 (3/3) MoeA N-terminal region (domain I and II) PF01712 (3/3) Deoxynucleoside kinase PF01435 (3/3) Peptidase family M48 PF00994 (3/3) Probable molybdopterin binding domain PF00300 (3/3) Histidine phosphatase superfamily (branch 1) PF00293 (3/3) NUDIX domain PF00113 (3/3) Enolase, C-terminal TIM barrel domain
jaccard_groups_4575	396.47 +- 171.88	3	0	0	0	0.01 +- 0.02	3	12 TIGR01549 (3/3) HAD hydrolase, family IA, variant 1 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF13535 (3/3) ATP-grasp domain PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF07690 (3/3) Major Facilitator Superfamily PF06245 (3/3) Protein of unknown function (DUF1015) PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
jaccard_groups_5088	376.25 +- 0.00	2	0	0	2	0.03 +- 0.03	2	20 TIGR01656 (2/2) histidinol-phosphate phosphatase domain TIGR01444 (2/2) methyltransferase, FkbM family PF16363 (2/2) GDP-mannose 4,6 dehydratase PF13242 (2/2) HAD-hyrolase-like PF12804 (2/2) MobA-like NTP transferase domain PF12146 (2/2) Serine aminopeptidase, S33 PF05050 (2/2) Methyltransferase FkbM domain PF04055 (2/2) Radical SAM superfamily PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PF02709 (2/2) N-terminal domain of galactosyltransferase PF01370 (2/2) NAD dependent epimerase/dehydratase family PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00891 (2/2) O-methyltransferase domain PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00535 (2/2) Glycosyl transferase family 2 PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain PF00293 (2/2) NUDIX domain PF00037 (2/2) 4Fe-4S binding domain
jaccard_groups_3228	169.73 +- 174.91	6	0	0	0	0.05 +- 0.09	6	10 TIGR00229 (6/6) PAS domain S-box protein PF08448 (6/6) PAS fold PF08220 (6/6) DeoR-like helix-turn-helix domain PF07228 (6/6) Stage II sporulation protein E (SpoIIE) PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain PF01590 (6/6) GAF domain PF00455 (6/6) DeoR C terminal sensor domain PF00440 (6/6) Bacterial regulatory proteins, tetR family PF00069 (6/6) Protein kinase domain PF01494 (3/6) FAD binding domain
jaccard_groups_278	125.60 +- 103.73	2	0	0	0	0.06 +- 0.13	2	4 PF03965 (2/2) Penicillinase repressor PF01435 (2/2) Peptidase family M48 PF08241 (1/2) Methyltransferase domain PF00149 (1/2) Calcineurin-like phosphoesterase
jaccard_groups_1313	119.65 +- 40.51	2	0	0	0	0.08 +- 0.07	2	15 PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF04199 (2/2) Putative cyclase PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family PF01494 (2/2) FAD binding domain PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TIGR01780 (1/2) succinate-semialdehyde dehydrogenase PF12802 (1/2) MarR family PF09339 (1/2) IclR helix-turn-helix domain PF07883 (1/2) Cupin domain PF07690 (1/2) Major Facilitator Superfamily PF04909 (1/2) Amidohydrolase PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF01614 (1/2) Bacterial transcriptional regulator PF00701 (1/2) Dihydrodipicolinate synthetase family PF00171 (1/2) Aldehyde dehydrogenase family
jaccard_groups_418	88.83 +- 41.22	3	0	2	0	0.03 +- 0.04	3	4 PF08031 (3/3) Berberine and berberine like PF01565 (3/3) FAD binding domain PF08386 (2/3) TAP-like protein PF00561 (2/3) alpha/beta hydrolase fold
jaccard_groups_413	197.80 +- 88.43	4	0	0	0	0.02 +- 0.01	4	4 PF02838 (4/4) Glycosyl hydrolase family 20, domain 2 PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain PF00754 (3/4) F5/8 type C domain PF01120 (2/4) Alpha-L-fucosidase
jaccard_groups_2173	216.00 +- 44.00	2	0	0	0	0.01 +- 0.00	2	3 PF13229 (2/2) Right handed beta helix region PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02018 (2/2) Carbohydrate binding domain
jaccard_groups_6027	100.28 +- 9.84	2	0	0	0	0.06 +- 0.06	2	6 PF14903 (2/2) WG containing repeat PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase PF00950 (2/2) ABC 3 transport family PF00583 (2/2) Acetyltransferase (GNAT) family PF00005 (2/2) ABC transporter
jaccard_groups_2106	429.44 +- 25.56	2	0	2	0	0.04 +- 0.04	2	26 TIGR01733 (2/2) amino acid adenylation domain PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain PF14518 (2/2) Iron-containing redox enzyme PF13714 (2/2) Phosphoenolpyruvate phosphomutase PF13535 (2/2) ATP-grasp domain PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring) PF13302 (2/2) Acetyltransferase (GNAT) domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF09334 (2/2) tRNA synthetases class I (M) PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF07883 (2/2) Cupin domain PF07690 (2/2) Major Facilitator Superfamily PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain PF03417 (2/2) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF01266 (2/2) FAD dependent oxidoreductase PF00975 (2/2) Thioesterase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00067 (2/2) Cytochrome P450 PF18563 (1/2) TubC N-terminal docking domain
jaccard_groups_3592	383.81 +- 168.05	5	0	0	5	0.01 +- 0.03	5	7 TIGR00702 (5/5) YcaO-type kinase domain PF18029 (5/5) Glyoxalase-like domain PF13489 (5/5) Methyltransferase domain PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase PF07812 (5/5) TfuA-like protein PF07690 (5/5) Major Facilitator Superfamily PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
jaccard_groups_2688	97.38 +- 49.07	3	0	0	0	0.05 +- 0.06	3	8 TIGR01180 (3/3) putative alpha-1,2-mannosidase PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain PF07971 (3/3) Glycosyl hydrolase family 92 PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00672 (3/3) HAMP domain PF00553 (3/3) Cellulose binding domain PF00512 (3/3) His Kinase A (phospho-acceptor) domain PF03067 (2/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
jaccard_groups_663	58.05 +- 5.27	3	0	0	0	0.05 +- 0.03	3	5 PF02386 (3/3) Cation transport protein PF02254 (3/3) TrkA-N domain PF02080 (3/3) TrkA-C domain PF13193 (2/3) AMP-binding enzyme C-terminal domain PF00501 (2/3) AMP-binding enzyme
jaccard_groups_2081	128.66 +- 34.98	4	0	0	0	0.02 +- 0.03	4	4 PF07690 (4/4) Major Facilitator Superfamily PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme PF13302 (2/4) Acetyltransferase (GNAT) domain PF01255 (2/4) Putative undecaprenyl diphosphate synthase
jaccard_groups_3774	303.45 +- 53.54	3	0	0	0	0.02 +- 0.01	3	8 PF17286 (3/3) PRMT5 oligomerisation domain PF14518 (3/3) Iron-containing redox enzyme PF13649 (3/3) Methyltransferase domain PF07732 (3/3) Multicopper oxidase PF01323 (3/3) DSBA-like thioredoxin domain PF00701 (3/3) Dihydrodipicolinate synthetase family PF00355 (3/3) Rieske [2Fe-2S] domain PF00155 (3/3) Aminotransferase class I and II
jaccard_groups_110	228.87 +- 47.17	10	0	0	0	0.01 +- 0.01	10	3 PF13545 (10/10) Crp-like helix-turn-helix domain PF00027 (10/10) Cyclic nucleotide-binding domain PF07228 (9/10) Stage II sporulation protein E (SpoIIE)
jaccard_groups_111	356.38 +- 193.33	3	0	3	0	0.02 +- 0.04	3	10 PF16197 (3/3) Ketoacyl-synthetase C-terminal extension PF14765 (3/3) Polyketide synthase dehydratase PF08659 (3/3) KR domain PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF00698 (3/3) Acyl transferase domain PF00550 (3/3) Phosphopantetheine attachment site PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF01648 (2/3) 4'-phosphopantetheinyl transferase superfamily PF00561 (2/3) alpha/beta hydrolase fold PF00201 (2/3) UDP-glucoronosyl and UDP-glucosyl transferase
jaccard_groups_2312	383.41 +- 360.05	8	0	1	0	0.06 +- 0.07	8	10 TIGR00976 (8/8) hydrolase CocE/NonD family protein PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family) PF00528 (8/8) Binding-protein-dependent transport system inner membrane component PF00005 (8/8) ABC transporter TIGR01726 (7/8) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family PF00583 (7/8) Acetyltransferase (GNAT) family PF00497 (7/8) Bacterial extracellular solute-binding proteins, family 3 PF01244 (6/8) Membrane dipeptidase (Peptidase family M19) PF00296 (4/8) Luciferase-like monooxygenase
jaccard_groups_119	480.00 +- 547.55	31	8	23	31	0.02 +- 0.03	23	5 TIGR03891 (31/31) thiopeptide-type bacteriocin biosynthesis domain PF14028 (31/31) Lantibiotic biosynthesis dehydratase C-term PF05147 (31/31) Lanthionine synthetase C-like protein PF04738 (30/31) Lantibiotic dehydratase, N terminus PF00005 (17/31) ABC transporter
jaccard_groups_2955	2158.41 +- 761.00	8	0	1	0	0.01 +- 0.01	8	12 PF13560 (8/8) Helix-turn-helix domain PF13393 (8/8) Histidyl-tRNA synthetase PF05193 (8/8) Peptidase M16 inactive domain PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02585 (8/8) GlcNAc-PI de-N-acetylase PF01370 (8/8) NAD dependent epimerase/dehydratase family PF01061 (8/8) ABC-2 type transporter PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00675 (8/8) Insulinase (Peptidase family M16) PF00005 (8/8) ABC transporter PF17874 (7/8) MalT-like TPR region
jaccard_groups_2817	415.68 +- 202.70	2	0	0	2	0.03 +- 0.02	2	12 TIGR04469 (2/2) CGA synthase-related protein TIGR04468 (2/2) arginine 2,3-aminomutase TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase TIGR04466 (2/2) cytosylglucuronate decarboxylase PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF08241 (2/2) Methyltransferase domain PF05014 (2/2) Nucleoside 2-deoxyribosyltransferase PF04055 (2/2) Radical SAM superfamily PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF07690 (1/2) Major Facilitator Superfamily PF01433 (1/2) Peptidase family M1 domain PF00296 (1/2) Luciferase-like monooxygenase
jaccard_groups_2774	885.57 +- 176.07	4	0	1	0	0.01 +- 0.01	4	9 TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily PF07690 (4/4) Major Facilitator Superfamily PF03737 (4/4) Aldolase/RraA PF03466 (4/4) LysR substrate binding domain PF01361 (4/4) Tautomerase enzyme PF00994 (4/4) Probable molybdopterin binding domain PF00682 (4/4) HMGL-like PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_1554	114.67 +- 64.87	3	0	1	0	0.06 +- 0.04	3	8 PF13193 (3/3) AMP-binding enzyme C-terminal domain PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain PF00501 (3/3) AMP-binding enzyme PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain PF14864 (2/3) Alkyl sulfatase C-terminal PF14863 (2/3) Alkyl sulfatase dimerisation PF00753 (2/3) Metallo-beta-lactamase superfamily
jaccard_groups_1000	306.75 +- 209.25	2	0	0	0	0.02 +- 0.02	2	8 PF13466 (2/2) STAS domain PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF02607 (2/2) B12 binding domain PF02310 (2/2) B12 binding domain PF08031 (1/2) Berberine and berberine like PF03992 (1/2) Antibiotic biosynthesis monooxygenase PF01565 (1/2) FAD binding domain PF00239 (1/2) Resolvase, N terminal domain
jaccard_groups_5850	977.21 +- 452.79	2	0	2	2	0.01 +- 0.02	2	25 TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase TIGR03969 (2/2) mycofactocin precursor TIGR03967 (2/2) putative mycofactocin binding protein MftB TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system TIGR03965 (2/2) mycofactocin system glycosyltransferase TIGR03964 (2/2) mycofactocin system creatininase family protein TIGR03962 (2/2) mycofactocin radical SAM maturase PF17676 (2/2) LD-carboxypeptidase C-terminal domain PF16861 (2/2) Carbamoyltransferase C-terminus PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13489 (2/2) Methyltransferase domain PF13186 (2/2) Iron-sulfur cluster-binding domain PF08242 (2/2) Methyltransferase domain PF04055 (2/2) Radical SAM superfamily PF03129 (2/2) Anticodon binding domain PF02633 (2/2) Creatinine amidohydrolase PF02543 (2/2) Carbamoyltransferase N-terminus PF02016 (2/2) LD-carboxypeptidase N-terminal domain PF01980 (2/2) tRNA-methyltransferase O PF01070 (2/2) FMN-dependent dehydrogenase PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T) PF00535 (2/2) Glycosyl transferase family 2 PF00152 (2/2) tRNA synthetases class II (D, K and N) PF00067 (2/2) Cytochrome P450
jaccard_groups_4050	300.06 +- 213.54	3	0	0	0	0.04 +- 0.05	3	7 PF17900 (3/3) Peptidase M1 N-terminal domain PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family PF01965 (3/3) DJ-1/PfpI family PF01433 (3/3) Peptidase family M1 domain PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00082 (3/3) Subtilase family
jaccard_groups_3817	1991.35 +- 896.21	5	0	5	0	0.02 +- 0.10	5	34 TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (5/5) diaminopimelate epimerase PF18603 (5/5) L-amino acid ligase C-terminal domain 2 PF18130 (5/5) ATP-grasp N-terminal domain PF14518 (5/5) Iron-containing redox enzyme PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal PF13535 (5/5) ATP-grasp domain PF13458 (5/5) Periplasmic binding protein PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter PF10014 (5/5) 2OG-Fe dioxygenase PF08241 (5/5) Methyltransferase domain PF07859 (5/5) alpha/beta hydrolase fold PF07690 (5/5) Major Facilitator Superfamily PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (5/5) Aminopeptidase P, N-terminal domain PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily PF02653 (5/5) Branched-chain amino acid transport system / permease component PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family PF02153 (5/5) Prephenate dehydrogenase PF01678 (5/5) Diaminopimelate epimerase PF01575 (5/5) MaoC like domain PF01568 (5/5) Molydopterin dinucleotide binding domain PF01425 (5/5) Amidase PF01070 (5/5) FMN-dependent dehydrogenase PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (5/5) EamA-like transporter family PF00682 (5/5) HMGL-like PF00557 (5/5) Metallopeptidase family M24 PF00384 (5/5) Molybdopterin oxidoreductase PF00248 (5/5) Aldo/keto reductase family PF00155 (5/5) Aminotransferase class I and II PF00005 (5/5) ABC transporter
jaccard_groups_3702	392.52 +- 261.55	4	0	1	0	0.04 +- 0.08	4	17 TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family TIGR01525 (4/4) heavy metal translocating P-type ATPase TIGR00802 (4/4) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family PF14237 (4/4) GYF domain 2 PF13421 (4/4) SPFH domain-Band 7 family PF08281 (4/4) Sigma-70, region 4 PF07690 (4/4) Major Facilitator Superfamily PF04542 (4/4) Sigma-70 region 2 PF04314 (4/4) Copper chaperone PCu(A)C PF03824 (4/4) High-affinity nickel-transport protein PF00702 (4/4) haloacid dehalogenase-like hydrolase PF00403 (4/4) Heavy-metal-associated domain PF00122 (4/4) E1-E2 ATPase PF13738 (3/4) Pyridine nucleotide-disulphide oxidoreductase PF01070 (3/4) FMN-dependent dehydrogenase PF00067 (3/4) Cytochrome P450 PF05118 (2/4) Aspartyl/Asparaginyl beta-hydroxylase
jaccard_groups_3700	32.13 +- 5.78	3	0	0	0	0.06 +- 0.11	3	6 TIGR01509 (3/3) HAD hydrolase, family IA, variant 3 PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF08386 (3/3) TAP-like protein PF04149 (3/3) Domain of unknown function (DUF397) PF02388 (3/3) FemAB family PF00561 (3/3) alpha/beta hydrolase fold
jaccard_groups_3813	277.22 +- 74.60	2	0	0	0	0.08 +- 0.08	2	22 TIGR01733 (2/2) amino acid adenylation domain PF18029 (2/2) Glyoxalase-like domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08713 (2/2) DNA alkylation repair enzyme PF08659 (2/2) KR domain PF07690 (2/2) Major Facilitator Superfamily PF07478 (2/2) D-ala D-ala ligase C-terminus PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01820 (2/2) D-ala D-ala ligase N-terminus PF01494 (2/2) FAD binding domain PF00975 (2/2) Thioesterase domain PF00850 (2/2) Histone deacetylase domain PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00698 (2/2) Acyl transferase domain PF00551 (2/2) Formyl transferase PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00355 (2/2) Rieske [2Fe-2S] domain PF00155 (2/2) Aminotransferase class I and II PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
jaccard_groups_2652	3474.49 +- 3174.88	2	0	0	0	0.04 +- 0.05	2	27 TIGR01928 (2/2) o-succinylbenzoate synthase TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF13556 (2/2) PucR C-terminal helix-turn-helix domain PF13378 (2/2) Enolase C-terminal domain-like PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07676 (2/2) WD40-like Beta Propeller Repeat PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01546 (2/2) Peptidase family M20/M25/M40 PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00326 (2/2) Prolyl oligopeptidase family PF00144 (2/2) Beta-lactamase PF00005 (2/2) ABC transporter PF17853 (1/2) GGDEF-like domain PF13354 (1/2) Beta-lactamase enzyme family PF13193 (1/2) AMP-binding enzyme C-terminal domain PF10400 (1/2) Virulence activator alpha C-term PF08667 (1/2) BetR domain PF07969 (1/2) Amidohydrolase family PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF03551 (1/2) Transcriptional regulator PadR-like family PF03061 (1/2) Thioesterase superfamily PF02687 (1/2) FtsX-like permease family PF01381 (1/2) Helix-turn-helix PF00743 (1/2) Flavin-binding monooxygenase-like PF00501 (1/2) AMP-binding enzyme
jaccard_groups_3955	1463.93 +- 1117.75	4	0	0	0	0.02 +- 0.01	4	14 PF18603 (4/4) L-amino acid ligase C-terminal domain 2 PF18130 (4/4) ATP-grasp N-terminal domain PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13535 (4/4) ATP-grasp domain PF13378 (4/4) Enolase C-terminal domain-like PF12146 (4/4) Serine aminopeptidase, S33 PF08241 (4/4) Methyltransferase domain PF07690 (4/4) Major Facilitator Superfamily PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH) PF03321 (4/4) GH3 auxin-responsive promoter PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF00694 (4/4) Aconitase C-terminal domain PF00330 (4/4) Aconitase family (aconitate hydratase)
jaccard_groups_2498	554.81 +- 177.49	10	0	0	0	0.02 +- 0.02	10	19 TIGR02124 (10/10) hydrogenase expression/formation protein HypE TIGR01891 (10/10) amidohydrolase TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase TIGR00143 (10/10) carbamoyltransferase HypF PF17788 (10/10) HypF Kae1-like domain PF13535 (10/10) ATP-grasp domain PF12680 (10/10) SnoaL-like domain PF07690 (10/10) Major Facilitator Superfamily PF07503 (10/10) HypF finger PF05977 (10/10) Transmembrane secretion effector PF02769 (10/10) AIR synthase related protein, C-terminal domain PF01546 (10/10) Peptidase family M20/M25/M40 PF01300 (10/10) Telomere recombination PF00857 (10/10) Isochorismatase family PF00708 (10/10) Acylphosphatase PF00586 (10/10) AIR synthase related protein, N-terminal domain PF00202 (10/10) Aminotransferase class-III PF00155 (10/10) Aminotransferase class I and II PF00583 (9/10) Acetyltransferase (GNAT) family
jaccard_groups_2553	191.56 +- 72.66	4	0	0	0	0.07 +- 0.11	4	11 TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF14224 (4/4) Domain of unknown function (DUF4331) PF08240 (4/4) Alcohol dehydrogenase GroES-like domain PF07690 (4/4) Major Facilitator Superfamily PF00925 (4/4) GTP cyclohydrolase II PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00107 (4/4) Zinc-binding dehydrogenase PF00082 (3/4) Subtilase family PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
jaccard_groups_1197	91.00 +- 39.00	2	0	0	0	0.03 +- 0.02	2	2 PF03130 (2/2) PBS lyase HEAT-like repeat PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
jaccard_groups_2227	192.59 +- 95.33	3	0	0	0	0.02 +- 0.05	3	4 PF11303 (3/3) Protein of unknown function (DUF3105) PF09286 (3/3) Pro-kumamolisin, activation domain PF03713 (3/3) Domain of unknown function (DUF305) PF00082 (3/3) Subtilase family
jaccard_groups_4625	189.23 +- 42.98	2	0	0	0	0.02 +- 0.01	2	5 PF13191 (2/2) AAA ATPase domain PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport PF05199 (2/2) GMC oxidoreductase PF00732 (2/2) GMC oxidoreductase PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_1074	32.50 +- 0.00	2	0	0	0	0.06 +- 0.05	2	2 TIGR03296 (2/2) M6 family metalloprotease domain PF01070 (2/2) FMN-dependent dehydrogenase
jaccard_groups_182	651.51 +- 518.49	2	0	0	0	0.05 +- 0.06	2	16 PF14310 (2/2) Fibronectin type III-like domain PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain PF01547 (2/2) Bacterial extracellular solute-binding protein PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family PF13802 (1/2) Galactose mutarotase-like PF13377 (1/2) Periplasmic binding protein-like domain PF04075 (1/2) F420H(2)-dependent quinone reductase PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain PF03633 (1/2) Glycosyl hydrolase family 65, C-terminal domain PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain PF03422 (1/2) Carbohydrate binding module (family 6) PF01055 (1/2) Glycosyl hydrolases family 31 PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_231	111.41 +- 17.59	2	0	1	0	0.04 +- 0.06	2	9 TIGR01180 (2/2) putative alpha-1,2-mannosidase PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain PF12833 (2/2) Helix-turn-helix domain PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07971 (2/2) Glycosyl hydrolase family 92 PF01965 (2/2) DJ-1/PfpI family PF00754 (2/2) F5/8 type C domain PF00107 (2/2) Zinc-binding dehydrogenase PF00857 (1/2) Isochorismatase family
jaccard_groups_230	182.88 +- 297.22	81	27	52	81	0.04 +- 0.03	54	3 PF13471 (81/81) Transglutaminase-like superfamily PF00733 (80/81) Asparagine synthase PF05402 (69/81) Coenzyme PQQ synthesis protein D (PqqD)
jaccard_groups_2429	462.83 +- 311.17	2	0	0	0	0.02 +- 0.04	2	6 PF03704 (2/2) Bacterial transcriptional activator domain PF02615 (2/2) Malate/L-lactate dehydrogenase PF01546 (2/2) Peptidase family M20/M25/M40 PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00486 (2/2) Transcriptional regulatory protein, C terminal
jaccard_groups_87	52.38 +- 14.29	14	0	2	0	0.07 +- 0.08	14	5 PF03450 (14/14) CO dehydrogenase flavoprotein C-terminal domain PF02738 (14/14) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (14/14) [2Fe-2S] binding domain PF01315 (14/14) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (14/14) FAD binding domain in molybdopterin dehydrogenase
jaccard_groups_3255	414.64 +- 27.64	2	0	0	0	0.01 +- 0.00	2	3 PF12697 (2/2) Alpha/beta hydrolase family PF07690 (2/2) Major Facilitator Superfamily PF00884 (2/2) Sulfatase
jaccard_groups_36	97.43 +- 4.08	3	0	0	0	0.02 +- 0.02	3	2 PF01636 (3/3) Phosphotransferase enzyme family PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
jaccard_groups_37	81.97 +- 63.87	3	0	0	0	0.04 +- 0.05	3	1 PF00106 (3/3) short chain dehydrogenase
jaccard_groups_34	791.63 +- 421.13	9	0	1	1	0.03 +- 0.11	9	5 TIGR01727 (9/9) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region PF00528 (9/9) Binding-protein-dependent transport system inner membrane component PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle PF00005 (9/9) ABC transporter
jaccard_groups_681	119.17 +- 54.17	2	0	1	0	0.03 +- 0.02	2	6 PF00754 (2/2) F5/8 type C domain PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF14099 (1/2) Polysaccharide lyase PF04616 (1/2) Glycosyl hydrolases family 43 PF01120 (1/2) Alpha-L-fucosidase PF00082 (1/2) Subtilase family
jaccard_groups_30	545.83 +- 791.07	15	0	15	1	0.03 +- 0.09	15	6 TIGR01733 (15/15) amino acid adenylation domain PF13193 (15/15) AMP-binding enzyme C-terminal domain PF00668 (15/15) Condensation domain PF00550 (15/15) Phosphopantetheine attachment site PF00501 (15/15) AMP-binding enzyme PF00975 (12/15) Thioesterase domain
jaccard_groups_31	170.84 +- 87.16	2	0	1	0	0.05 +- 0.09	2	3 PF00067 (2/2) Cytochrome P450 PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01427 (1/2) D-ala-D-ala dipeptidase
jaccard_groups_39	108.86 +- 77.01	24	0	2	0	0.03 +- 0.04	24	2 PF00561 (24/24) alpha/beta hydrolase fold PF08386 (16/24) TAP-like protein
jaccard_groups_849	81.64 +- 74.60	8	0	0	0	0.05 +- 0.05	8	2 PF01874 (8/8) ATP:dephospho-CoA triphosphoribosyl transferase PF00775 (8/8) Dioxygenase
jaccard_groups_334	104.13 +- 69.20	2	0	0	0	0.08 +- 0.16	2	6 TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF13454 (2/2) FAD-NAD(P)-binding PF07920 (2/2) Protein of unknown function (DUF1684) PF02983 (2/2) Alpha-lytic protease prodomain PF00296 (2/2) Luciferase-like monooxygenase PF00089 (2/2) Trypsin
jaccard_groups_333	132.81 +- 14.62	2	0	0	0	0.03 +- 0.04	2	5 PF01738 (2/2) Dienelactone hydrolase family PF00583 (1/2) Acetyltransferase (GNAT) family PF00156 (1/2) Phosphoribosyl transferase domain PF00082 (1/2) Subtilase family PF00005 (1/2) ABC transporter
jaccard_groups_1216	123.93 +- 11.86	2	0	1	0	0.04 +- 0.05	2	11 PF04444 (2/2) Catechol dioxygenase N terminus PF00775 (2/2) Dioxygenase PF00465 (2/2) Iron-containing alcohol dehydrogenase PF14525 (1/2) AraC-binding-like domain PF12833 (1/2) Helix-turn-helix domain PF07730 (1/2) Histidine kinase PF03466 (1/2) LysR substrate binding domain PF01494 (1/2) FAD binding domain PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00072 (1/2) Response regulator receiver domain
jaccard_groups_4801	122.27 +- 27.73	2	0	2	0	0.02 +- 0.01	2	6 PF04073 (2/2) Aminoacyl-tRNA editing domain PF01116 (2/2) Fructose-bisphosphate aldolase class-II PF00892 (2/2) EamA-like transporter family PF00464 (2/2) Serine hydroxymethyltransferase PF04151 (1/2) Bacterial pre-peptidase C-terminal domain PF00082 (1/2) Subtilase family
jaccard_groups_6262	523.42 +- 54.35	2	0	2	2	0.05 +- 0.08	2	18 TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein TIGR00594 (2/2) DNA polymerase III, alpha subunit PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain PF14579 (2/2) Helix-hairpin-helix motif PF13575 (2/2) Domain of unknown function (DUF4135) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain PF05147 (2/2) Lanthionine synthetase C-like protein PF03412 (2/2) Peptidase C39 family PF02811 (2/2) PHP domain PF01336 (2/2) OB-fold nucleic acid binding domain PF00664 (2/2) ABC transporter transmembrane region PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region PF00107 (2/2) Zinc-binding dehydrogenase PF00005 (2/2) ABC transporter PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF07366 (1/2) SnoaL-like polyketide cyclase
jaccard_groups_3405	505.11 +- 323.47	3	0	0	0	0.03 +- 0.09	3	12 TIGR00556 (3/3) phosphopantetheine--protein transferase domain TIGR00027 (3/3) methyltransferase, TIGR00027 family PF12706 (3/3) Beta-lactamase superfamily domain PF11583 (3/3) P-aminobenzoate N-oxygenase AurF PF07690 (3/3) Major Facilitator Superfamily PF06628 (3/3) Catalase-related immune-responsive PF04072 (3/3) Leucine carboxyl methyltransferase PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily PF01575 (3/3) MaoC like domain PF00550 (3/3) Phosphopantetheine attachment site PF00199 (3/3) Catalase PF09947 (2/3) Uncharacterized protein conserved in archaea (DUF2180)
jaccard_groups_337	205.76 +- 106.24	2	0	0	0	0.06 +- 0.13	2	8 PF05199 (2/2) GMC oxidoreductase PF00732 (2/2) GMC oxidoreductase TIGR02462 (1/2) pyranose oxidase PF12902 (1/2) Ferritin-like PF07690 (1/2) Major Facilitator Superfamily PF03928 (1/2) Haem-degrading PF01551 (1/2) Peptidase family M23 PF01471 (1/2) Putative peptidoglycan binding domain
jaccard_groups_6471	545.32 +- 29.32	2	0	0	0	0.01 +- 0.00	2	9 PF04199 (2/2) Putative cyclase PF02728 (2/2) Copper amine oxidase, N3 domain PF01179 (2/2) Copper amine oxidase, enzyme domain PF01019 (2/2) Gamma-glutamyltranspeptidase PF00355 (2/2) Rieske [2Fe-2S] domain PF00175 (2/2) Oxidoreductase NAD-binding domain PF00120 (2/2) Glutamine synthetase, catalytic domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00753 (1/2) Metallo-beta-lactamase superfamily
jaccard_groups_529	183.10 +- 82.91	6	0	0	0	0.01 +- 0.01	6	1 PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
jaccard_groups_247	426.40 +- 283.00	8	2	6	8	0.02 +- 0.05	6	11 TIGR03897 (8/8) type 2 lantibiotic biosynthesis protein LanM PF13575 (8/8) Domain of unknown function (DUF4135) PF05147 (8/8) Lanthionine synthetase C-like protein PF03704 (6/8) Bacterial transcriptional activator domain PF00486 (6/8) Transcriptional regulatory protein, C terminal PF13191 (5/8) AAA ATPase domain PF00931 (5/8) NB-ARC domain PF00196 (5/8) Bacterial regulatory proteins, luxR family PF13185 (4/8) GAF domain PF08448 (4/8) PAS fold PF07228 (4/8) Stage II sporulation protein E (SpoIIE)
jaccard_groups_428	50.92 +- 20.56	4	0	1	0	0.06 +- 0.05	4	3 PF00174 (4/4) Oxidoreductase molybdopterin binding domain PF01292 (3/4) Prokaryotic cytochrome b561 PF07519 (2/4) Tannase and feruloyl esterase
jaccard_groups_740	91.14 +- 8.59	3	0	0	0	0.03 +- 0.04	3	4 PF13480 (3/3) Acetyltransferase (GNAT) domain PF02156 (3/3) Glycosyl hydrolase family 26 PF01522 (3/3) Polysaccharide deacetylase PF00535 (3/3) Glycosyl transferase family 2
jaccard_groups_2136	953.88 +- 214.88	6	2	0	6	0.01 +- 0.01	4	7 TIGR04085 (6/6) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (6/6) Iron-sulfur cluster-binding domain PF05402 (6/6) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (6/6) Radical SAM superfamily PF00005 (6/6) ABC transporter PF01061 (4/6) ABC-2 type transporter PF00717 (4/6) Peptidase S24-like
jaccard_groups_1286	142.22 +- 29.78	2	0	2	0	0.06 +- 0.03	2	8 PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain PF07690 (2/2) Major Facilitator Superfamily PF03466 (2/2) LysR substrate binding domain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00754 (2/2) F5/8 type C domain PF00703 (2/2) Glycosyl hydrolases family 2 PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_6065	1029.17 +- 97.50	2	0	2	0	0.01 +- 0.01	2	11 PF12146 (2/2) Serine aminopeptidase, S33 PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport PF09924 (2/2) Uncharacterised conserved protein (DUF2156) PF08448 (2/2) PAS fold PF07993 (2/2) Male sterility protein PF07690 (2/2) Major Facilitator Superfamily PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport PF01613 (2/2) Flavin reductase like domain PF00899 (2/2) ThiF family PF00202 (2/2) Aminotransferase class-III PF00196 (2/2) Bacterial regulatory proteins, luxR family
jaccard_groups_1283	491.11 +- 40.86	3	0	0	0	0.01 +- 0.00	3	3 PF07690 (3/3) Major Facilitator Superfamily PF18029 (2/3) Glyoxalase-like domain PF00903 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_2911	759.98 +- 690.09	3	0	3	3	0.06 +- 0.20	3	6 PF06114 (3/3) IrrE N-terminal-like domain PF05147 (3/3) Lanthionine synthetase C-like protein PF02687 (3/3) FtsX-like permease family PF00082 (3/3) Subtilase family PF00069 (3/3) Protein kinase domain PF00005 (3/3) ABC transporter
jaccard_groups_1296	478.51 +- 301.49	2	0	2	0	0.03 +- 0.05	2	16 PF14765 (2/2) Polyketide synthase dehydratase PF13489 (2/2) Methyltransferase domain PF08659 (2/2) KR domain PF03060 (2/2) Nitronate monooxygenase PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain TIGR01426 (1/2) glycosyltransferase, MGT family PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF12146 (1/2) Serine aminopeptidase, S33 PF07859 (1/2) alpha/beta hydrolase fold PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily PF00561 (1/2) alpha/beta hydrolase fold PF00440 (1/2) Bacterial regulatory proteins, tetR family
jaccard_groups_2148	178.59 +- 147.68	3	0	0	0	0.04 +- 0.04	3	3 PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase PF00067 (3/3) Cytochrome P450 PF03745 (2/3) Domain of unknown function (DUF309)
jaccard_groups_6081	895.44 +- 308.77	2	0	2	0	0.02 +- 0.03	2	15 TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF06368 (2/2) Methylaspartate mutase E chain (MutE) PF06339 (2/2) Ectoine synthase PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02310 (2/2) B12 binding domain PF01841 (2/2) Transglutaminase-like superfamily PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_3628	2401.56 +- 1135.16	3	0	0	0	0.02 +- 0.01	3	13 TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (3/3) ATP-grasp domain PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (3/3) Prephenate dehydrogenase PF01613 (3/3) Flavin reductase like domain PF01070 (3/3) FMN-dependent dehydrogenase PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (3/3) Luciferase-like monooxygenase PF00155 (3/3) Aminotransferase class I and II PF00106 (3/3) short chain dehydrogenase PF18130 (2/3) ATP-grasp N-terminal domain
jaccard_groups_142	126.17 +- 68.83	2	0	0	0	0.03 +- 0.04	2	4 PF04978 (2/2) Protein of unknown function (DUF664) PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF03795 (1/2) YCII-related domain PF01636 (1/2) Phosphotransferase enzyme family
jaccard_groups_145	388.16 +- 408.77	6	0	0	0	0.05 +- 0.11	6	7 PF13407 (6/6) Periplasmic binding protein domain PF02653 (6/6) Branched-chain amino acid transport system / permease component PF00005 (6/6) ABC transporter PF13377 (5/6) Periplasmic binding protein-like domain PF00356 (5/6) Bacterial regulatory proteins, lacI family PF00294 (5/6) pfkB family carbohydrate kinase PF05025 (4/6) RbsD / FucU transport protein family
jaccard_groups_6059	1548.00 +- 0.00	2	0	0	2	0.01 +- 0.00	2	17 TIGR01549 (2/2) HAD hydrolase, family IA, variant 1 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF13242 (2/2) HAD-hyrolase-like PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12833 (2/2) Helix-turn-helix domain PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF04055 (2/2) Radical SAM superfamily PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain PF02811 (2/2) PHP domain PF02310 (2/2) B12 binding domain PF01522 (2/2) Polysaccharide deacetylase PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF00535 (2/2) Glycosyl transferase family 2 PF00501 (2/2) AMP-binding enzyme PF00202 (2/2) Aminotransferase class-III
jaccard_groups_2269	155.79 +- 11.35	2	0	2	0	0.03 +- 0.07	2	17 TIGR01733 (2/2) amino acid adenylation domain PF07690 (2/2) Major Facilitator Superfamily PF01361 (2/2) Tautomerase enzyme PF00975 (2/2) Thioesterase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 PF17645 (1/2) Arylmalonate decarboxylase PF14681 (1/2) Uracil phosphoribosyltransferase PF14027 (1/2) Questin oxidase-like PF13419 (1/2) Haloacid dehalogenase-like hydrolase PF11695 (1/2) Domain of unknown function (DUF3291) PF08962 (1/2) Domain of unknown function (DUF1876) PF08386 (1/2) TAP-like protein PF04227 (1/2) Indigoidine synthase A like protein PF00561 (1/2) alpha/beta hydrolase fold PF00144 (1/2) Beta-lactamase
jaccard_groups_2348	481.99 +- 169.64	10	0	10	0	0.02 +- 0.01	10	14 TIGR01850 (10/10) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (10/10) alpha-L-glutamate ligase, RimK family PF13193 (10/10) AMP-binding enzyme C-terminal domain PF08443 (10/10) RimK-like ATP-grasp domain PF02780 (10/10) Transketolase, C-terminal domain PF02779 (10/10) Transketolase, pyrimidine binding domain PF02771 (10/10) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (10/10) Acyl-CoA dehydrogenase, middle domain PF01118 (10/10) Semialdehyde dehydrogenase, NAD binding domain PF00501 (10/10) AMP-binding enzyme PF00456 (10/10) Transketolase, thiamine diphosphate binding domain PF00441 (10/10) Acyl-CoA dehydrogenase, C-terminal domain PF03466 (9/10) LysR substrate binding domain PF00126 (9/10) Bacterial regulatory helix-turn-helix protein, lysR family
jaccard_groups_2263	133.48 +- 31.64	2	0	0	0	0.04 +- 0.04	2	6 PF13649 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF02899 (2/2) Phage integrase, N-terminal SAM-like domain PF01636 (2/2) Phosphotransferase enzyme family PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00293 (2/2) NUDIX domain
jaccard_groups_4149	75.88 +- 0.00	2	0	0	2	0.07 +- 0.07	2	14 TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme TIGR01828 (2/2) pyruvate, phosphate dikinase TIGR01255 (2/2) formate acetyltransferase PF14325 (2/2) Domain of unknown function (DUF4383) PF13411 (2/2) MerR HTH family regulatory protein PF04055 (2/2) Radical SAM superfamily PF02901 (2/2) Pyruvate formate lyase-like PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain PF02607 (2/2) B12 binding domain PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01228 (2/2) Glycine radical PF00582 (2/2) Universal stress protein family PF00391 (2/2) PEP-utilising enzyme, mobile domain PF00106 (2/2) short chain dehydrogenase
jaccard_groups_1913	91.36 +- 15.97	3	0	0	0	0.06 +- 0.11	3	8 PF12450 (3/3) von Willebrand factor PF12034 (3/3) Domain of unknown function (DUF3520) PF10502 (3/3) Signal peptidase, peptidase S26 PF07291 (3/3) Methylamine utilisation protein MauE PF00717 (3/3) Peptidase S24-like PF00501 (3/3) AMP-binding enzyme PF00092 (3/3) von Willebrand factor type A domain PF00005 (3/3) ABC transporter
jaccard_groups_1527	152.71 +- 40.50	3	0	0	0	0.02 +- 0.01	3	3 PF07690 (3/3) Major Facilitator Superfamily PF01227 (3/3) GTP cyclohydrolase I PF00293 (3/3) NUDIX domain
jaccard_groups_4412	1472.40 +- 491.27	3	0	0	0	0.01 +- 0.01	3	17 TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF13378 (3/3) Enolase C-terminal domain-like PF13183 (3/3) 4Fe-4S dicluster domain PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region PF07729 (3/3) FCD domain PF03737 (3/3) Aldolase/RraA PF02913 (3/3) FAD linked oxidases, C-terminal domain PF02754 (3/3) Cysteine-rich domain PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01565 (3/3) FAD binding domain PF01229 (3/3) Glycosyl hydrolases family 39 PF00528 (3/3) Binding-protein-dependent transport system inner membrane component PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00171 (3/3) Aldehyde dehydrogenase family PF00005 (3/3) ABC transporter
jaccard_groups_4066	107.65 +- 48.04	3	0	0	0	0.07 +- 0.07	3	5 PF01427 (3/3) D-ala-D-ala dipeptidase PF00293 (3/3) NUDIX domain PF00005 (3/3) ABC transporter PF01425 (2/3) Amidase PF00069 (2/3) Protein kinase domain
jaccard_groups_5801	694.47 +- 44.47	2	0	2	2	0.01 +- 0.00	2	9 TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1 PF13649 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF05193 (2/2) Peptidase M16 inactive domain PF04989 (2/2) Cephalosporin hydroxylase PF04055 (2/2) Radical SAM superfamily PF02310 (2/2) B12 binding domain PF00805 (2/2) Pentapeptide repeats (8 copies) PF00675 (2/2) Insulinase (Peptidase family M16)
jaccard_groups_2297	226.23 +- 76.62	10	0	0	0	0.05 +- 0.04	10	10 TIGR00976 (10/10) hydrolase CocE/NonD family protein PF08530 (10/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (10/10) alpha/beta hydrolase fold PF02129 (10/10) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (10/10) Phosphotriesterase family PF01494 (10/10) FAD binding domain PF00753 (10/10) Metallo-beta-lactamase superfamily PF07690 (9/10) Major Facilitator Superfamily PF03781 (9/10) Sulfatase-modifying factor enzyme 1 PF00884 (9/10) Sulfatase
jaccard_groups_4385	113.39 +- 34.95	4	0	0	0	0.06 +- 0.10	4	7 PF13581 (4/4) Histidine kinase-like ATPase domain PF07690 (4/4) Major Facilitator Superfamily PF07681 (4/4) DoxX PF02515 (4/4) CoA-transferase family III PF01546 (4/4) Peptidase family M20/M25/M40 PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00378 (4/4) Enoyl-CoA hydratase/isomerase
jaccard_groups_4380	778.00 +- 2.83	3	0	0	3	0.01 +- 0.00	3	8 TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (3/3) SagB-type dehydrogenase domain PF16058 (3/3) Mucin-like PF07690 (3/3) Major Facilitator Superfamily PF03972 (3/3) MmgE/PrpD family PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (3/3) Nitroreductase family PF00675 (3/3) Insulinase (Peptidase family M16)
jaccard_groups_4068	234.00 +- 26.00	2	0	0	0	0.01 +- 0.01	2	6 PF12146 (2/2) Serine aminopeptidase, S33 PF10006 (2/2) Uncharacterized conserved protein (DUF2249) PF09339 (2/2) IclR helix-turn-helix domain PF01979 (2/2) Amidohydrolase family PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family PF00899 (2/2) ThiF family
jaccard_groups_3966	394.50 +- 74.31	5	0	0	0	0.02 +- 0.03	5	6 PF08386 (5/5) TAP-like protein PF07690 (5/5) Major Facilitator Superfamily PF01979 (5/5) Amidohydrolase family PF00561 (5/5) alpha/beta hydrolase fold PF00326 (5/5) Prolyl oligopeptidase family PF13649 (3/5) Methyltransferase domain
jaccard_groups_1140	593.76 +- 477.93	2	0	0	0	0.04 +- 0.08	2	15 TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family TIGR01525 (2/2) heavy metal translocating P-type ATPase PF17197 (2/2) Domain of unknown function (DUF5134) PF08281 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF04314 (2/2) Copper chaperone PCu(A)C PF03929 (2/2) PepSY-associated TM region PF01965 (2/2) DJ-1/PfpI family PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00403 (2/2) Heavy-metal-associated domain PF00122 (2/2) E1-E2 ATPase PF12833 (1/2) Helix-turn-helix domain PF01497 (1/2) Periplasmic binding protein PF01032 (1/2) FecCD transport family PF00005 (1/2) ABC transporter
jaccard_groups_46	350.14 +- 165.86	2	0	1	0	0.02 +- 0.02	2	9 PF07729 (2/2) FCD domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF13714 (1/2) Phosphoenolpyruvate phosphomutase PF13699 (1/2) Domain of unknown function (DUF4157) PF13649 (1/2) Methyltransferase domain PF07969 (1/2) Amidohydrolase family PF01083 (1/2) Cutinase PF00975 (1/2) Thioesterase domain PF00248 (1/2) Aldo/keto reductase family
jaccard_groups_45	358.78 +- 294.16	3	0	0	0	0.01 +- 0.01	3	1 PF01494 (3/3) FAD binding domain
jaccard_groups_42	363.14 +- 500.69	11	0	1	0	0.03 +- 0.06	11	2 PF13193 (11/11) AMP-binding enzyme C-terminal domain PF00501 (11/11) AMP-binding enzyme
jaccard_groups_4201	335.33 +- 121.62	4	0	1	0	0.04 +- 0.03	4	9 TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence PF13377 (4/4) Periplasmic binding protein-like domain PF02065 (4/4) Melibiase PF01547 (4/4) Bacterial extracellular solute-binding protein PF00652 (4/4) Ricin-type beta-trefoil lectin domain PF00528 (4/4) Binding-protein-dependent transport system inner membrane component PF00356 (4/4) Bacterial regulatory proteins, lacI family PF12833 (3/4) Helix-turn-helix domain PF01965 (3/4) DJ-1/PfpI family
jaccard_groups_1629	185.37 +- 61.16	8	0	0	0	0.09 +- 0.08	8	17 PF16875 (8/8) Glycosyl hydrolase family 36 N-terminal domain PF16874 (8/8) Glycosyl hydrolase family 36 C-terminal domain PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase PF13378 (8/8) Enolase C-terminal domain-like PF08450 (8/8) SMP-30/Gluconolactonase/LRE-like region PF07729 (8/8) FCD domain PF02746 (8/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (8/8) Melibiase PF01547 (8/8) Bacterial extracellular solute-binding protein PF01081 (8/8) KDPG and KHG aldolase PF00528 (8/8) Binding-protein-dependent transport system inner membrane component PF00392 (8/8) Bacterial regulatory proteins, gntR family PF00294 (8/8) pfkB family carbohydrate kinase PF17801 (7/8) Alpha galactosidase C-terminal beta sandwich domain PF16499 (7/8) Alpha galactosidase A PF00583 (6/8) Acetyltransferase (GNAT) family TIGR01409 (4/8) Tat (twin-arginine translocation) pathway signal sequence
jaccard_groups_4707	77.60 +- 25.60	2	0	0	0	0.03 +- 0.02	2	6 PF14525 (2/2) AraC-binding-like domain PF12833 (2/2) Helix-turn-helix domain PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF01551 (2/2) Peptidase family M23 PF01471 (2/2) Putative peptidoglycan binding domain PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
jaccard_groups_5243	3120.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	13 TIGR04245 (2/2) N-acyltransferase NodA TIGR04243 (2/2) chitooligosaccharide deacetylase NodB TIGR04242 (2/2) chitooligosaccharide synthase NodC TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02474 (2/2) Nodulation protein A (NodA) PF01522 (2/2) Polysaccharide deacetylase PF01061 (2/2) ABC-2 type transporter PF00535 (2/2) Glycosyl transferase family 2 PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (2/2) ABC transporter
jaccard_groups_3848	240.43 +- 106.11	3	0	3	0	0.01 +- 0.02	3	4 TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme PF01266 (3/3) FAD dependent oxidoreductase PF01019 (3/3) Gamma-glutamyltranspeptidase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
jaccard_groups_881	363.96 +- 245.86	3	0	0	0	0.04 +- 0.02	3	8 TIGR00126 (3/3) deoxyribose-phosphate aldolase PF13407 (3/3) Periplasmic binding protein domain PF07702 (3/3) UTRA domain PF05025 (3/3) RbsD / FucU transport protein family PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00005 (3/3) ABC transporter PF02653 (2/3) Branched-chain amino acid transport system / permease component PF00294 (2/3) pfkB family carbohydrate kinase
jaccard_groups_929	167.23 +- 13.37	2	0	0	0	0.06 +- 0.04	2	13 TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA TIGR00972 (2/2) phosphate ABC transporter, ATP-binding protein PF16640 (2/2) Bacterial Ig-like domain (group 3) PF12849 (2/2) PBP superfamily domain PF04203 (2/2) Sortase domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00041 (2/2) Fibronectin type III domain PF00005 (2/2) ABC transporter TIGR01076 (1/2) sortase PF12833 (1/2) Helix-turn-helix domain PF06719 (1/2) AraC-type transcriptional regulator N-terminus PF00106 (1/2) short chain dehydrogenase
jaccard_groups_567	411.00 +- 239.00	2	0	0	0	0.01 +- 0.01	2	15 PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain PF13377 (1/2) Periplasmic binding protein-like domain PF12146 (1/2) Serine aminopeptidase, S33 PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif PF05592 (1/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain PF01979 (1/2) Amidohydrolase family PF01494 (1/2) FAD binding domain PF01483 (1/2) Proprotein convertase P-domain PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain PF00754 (1/2) F5/8 type C domain PF00561 (1/2) alpha/beta hydrolase fold PF00356 (1/2) Bacterial regulatory proteins, lacI family
jaccard_groups_5347	216.17 +- 107.83	2	0	0	0	0.04 +- 0.05	2	9 TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family TIGR01979 (2/2) cysteine desulfurase, SufS family PF16868 (2/2) NMT1-like family PF05977 (2/2) Transmembrane secretion effector PF04185 (2/2) Phosphoesterase family PF00266 (2/2) Aminotransferase class-V PF00027 (2/2) Cyclic nucleotide-binding domain TIGR01167 (1/2) LPXTG cell wall anchor domain PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
jaccard_groups_158	93.07 +- 22.71	2	0	0	0	0.03 +- 0.04	2	11 TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain PF03816 (2/2) Cell envelope-related transcriptional attenuator domain PF13641 (1/2) Glycosyltransferase like family 2 PF13399 (1/2) LytR cell envelope-related transcriptional attenuator PF07730 (1/2) Histidine kinase PF07366 (1/2) SnoaL-like polyketide cyclase PF01522 (1/2) Polysaccharide deacetylase PF00561 (1/2) alpha/beta hydrolase fold PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00082 (1/2) Subtilase family PF00072 (1/2) Response regulator receiver domain
jaccard_groups_4964	454.25 +- 29.50	2	0	2	2	0.02 +- 0.02	2	13 TIGR00928 (2/2) adenylosuccinate lyase PF13673 (2/2) Acetyltransferase (GNAT) domain PF13454 (2/2) FAD-NAD(P)-binding PF10397 (2/2) Adenylosuccinate lyase C-terminus PF07969 (2/2) Amidohydrolase family PF07690 (2/2) Major Facilitator Superfamily PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF03704 (2/2) Bacterial transcriptional activator domain PF01425 (2/2) Amidase PF00931 (2/2) NB-ARC domain PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00206 (2/2) Lyase PF00120 (2/2) Glutamine synthetase, catalytic domain
jaccard_groups_4841	1530.48 +- 523.91	3	0	2	0	0.01 +- 0.03	3	14 PF05193 (3/3) Peptidase M16 inactive domain PF01937 (3/3) Protein of unknown function DUF89 PF01326 (3/3) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01061 (3/3) ABC-2 type transporter PF00675 (3/3) Insulinase (Peptidase family M16) PF00391 (3/3) PEP-utilising enzyme, mobile domain PF00300 (3/3) Histidine phosphatase superfamily (branch 1) PF00005 (3/3) ABC transporter PF13649 (2/3) Methyltransferase domain PF03965 (2/3) Penicillinase repressor PF01475 (2/3) Ferric uptake regulator family PF01435 (2/3) Peptidase family M48 PF00583 (2/3) Acetyltransferase (GNAT) family PF00196 (2/3) Bacterial regulatory proteins, luxR family
jaccard_groups_4518	186.14 +- 8.86	2	0	0	0	0.03 +- 0.04	2	6 PF13564 (2/2) DoxX-like family PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF03358 (2/2) NADPH-dependent FMN reductase PF00440 (2/2) Bacterial regulatory proteins, tetR family PF18616 (1/2) CDI immunity proteins
jaccard_groups_208	196.06 +- 138.24	10	0	0	10	0.03 +- 0.08	10	10 TIGR04269 (10/10) radical SAM/SPASM domain protein, FxsB family TIGR04267 (10/10) HEXXH motif domain PF13676 (10/10) TIR domain PF13424 (10/10) Tetratricopeptide repeat PF13374 (10/10) Tetratricopeptide repeat PF04055 (10/10) Radical SAM superfamily PF00931 (8/10) NB-ARC domain TIGR04268 (7/10) FXSXX-COOH protein TIGR04276 (6/10) FxsC C-terminal domain PF01656 (5/10) CobQ/CobB/MinD/ParA nucleotide binding domain
jaccard_groups_366	28.64 +- 10.40	3	0	0	0	0.09 +- 0.13	3	5 TIGR01701 (3/3) oxidoreductase alpha (molybdopterin) subunit PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport PF01568 (3/3) Molydopterin dinucleotide binding domain PF00384 (3/3) Molybdopterin oxidoreductase PF07077 (2/3) Protein of unknown function (DUF1345)
jaccard_groups_1996	411.81 +- 445.80	5	0	2	0	0.06 +- 0.08	5	6 TIGR01972 (5/5) proton-translocating NADH-quinone oxidoreductase, chain M PF00507 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 PF00499 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 6 PF00420 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PF00361 (5/5) Proton-conducting membrane transporter PF00146 (5/5) NADH dehydrogenase
jaccard_groups_1363	650.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	1 PF13367 (2/2) PrsW family intramembrane metalloprotease
jaccard_groups_1360	40.01 +- 4.56	2	0	1	0	0.06 +- 0.06	2	5 PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (2/2) [2Fe-2S] binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF13191 (1/2) AAA ATPase domain PF00196 (1/2) Bacterial regulatory proteins, luxR family
jaccard_groups_3444	218.17 +- 57.06	5	0	5	5	0.05 +- 0.06	5	9 PF08386 (5/5) TAP-like protein PF05532 (5/5) CsbD-like PF05147 (5/5) Lanthionine synthetase C-like protein PF00664 (5/5) ABC transporter transmembrane region PF00561 (5/5) alpha/beta hydrolase fold PF00069 (5/5) Protein kinase domain PF00005 (5/5) ABC transporter PF12697 (4/5) Alpha/beta hydrolase family PF00117 (3/5) Glutamine amidotransferase class-I
jaccard_groups_6222	103.09 +- 21.09	2	0	0	0	0.06 +- 0.08	2	7 TIGR01496 (2/2) dihydropteroate synthase PF08310 (2/2) LGFP repeat PF07995 (2/2) Glucose / Sorbosone dehydrogenase PF03734 (2/2) L,D-transpeptidase catalytic domain PF00809 (2/2) Pterin binding enzyme PF00801 (2/2) PKD domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
jaccard_groups_777	29.90 +- 5.84	3	0	0	0	0.08 +- 0.09	3	4 PF13516 (3/3) Leucine Rich repeat PF13203 (3/3) Putative metallopeptidase domain PF09967 (3/3) VWA-like domain (DUF2201) PF07728 (3/3) AAA domain (dynein-related subfamily)
jaccard_groups_772	455.00 +- 195.00	2	0	0	0	0.01 +- 0.00	2	3 PF00246 (2/2) Zinc carboxypeptidase PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236) PF00082 (1/2) Subtilase family
jaccard_groups_3664	174.93 +- 114.89	6	0	0	0	0.03 +- 0.05	6	8 PF13577 (6/6) SnoaL-like domain PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase PF12697 (6/6) Alpha/beta hydrolase family PF07690 (6/6) Major Facilitator Superfamily PF04444 (6/6) Catechol dioxygenase N terminus PF01261 (6/6) Xylose isomerase-like TIM barrel PF00775 (6/6) Dioxygenase PF00465 (6/6) Iron-containing alcohol dehydrogenase
jaccard_groups_3665	782.11 +- 340.79	6	0	0	0	0.01 +- 0.01	6	6 TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain TIGR01420 (6/6) twitching motility protein PF07963 (6/6) Prokaryotic N-terminal methylation motif PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain PF00482 (6/6) Type II secretion system (T2SS), protein F PF00437 (6/6) Type II/IV secretion system protein
jaccard_groups_3660	174.02 +- 47.17	5	0	0	0	0.07 +- 0.10	5	7 PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF12680 (5/5) SnoaL-like domain PF07045 (5/5) Domain of unknown function (DUF1330) PF01738 (5/5) Dienelactone hydrolase family PF00664 (5/5) ABC transporter transmembrane region PF00440 (5/5) Bacterial regulatory proteins, tetR family PF00005 (5/5) ABC transporter
jaccard_groups_1887	48.84 +- 15.40	2	0	0	0	0.09 +- 0.08	2	8 TIGR00072 (2/2) hydrogenase maturation protease PF17179 (2/2) 4Fe-4S dicluster domain PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PF01750 (2/2) Hydrogenase maturation protease PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit PF00374 (2/2) Nickel-dependent hydrogenase PF00175 (2/2) Oxidoreductase NAD-binding domain PF00027 (2/2) Cyclic nucleotide-binding domain
jaccard_groups_100	283.77 +- 123.70	5	0	0	0	0.04 +- 0.06	5	2 PF17964 (5/5) Bacterial Ig domain PF03734 (5/5) L,D-transpeptidase catalytic domain
jaccard_groups_103	26.66 +- 3.06	3	0	0	0	0.07 +- 0.07	3	3 PF00652 (3/3) Ricin-type beta-trefoil lectin domain PF00457 (2/3) Glycosyl hydrolases family 11 PF00331 (2/3) Glycosyl hydrolase family 10
jaccard_groups_102	712.17 +- 360.81	9	0	8	6	0.05 +- 0.13	9	11 TIGR03797 (9/9) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (9/9) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein PF03412 (9/9) Peptidase C39 family PF00664 (9/9) ABC transporter transmembrane region PF00005 (9/9) ABC transporter PF13437 (8/9) HlyD family secretion protein TIGR03882 (6/9) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (6/9) SagB-type dehydrogenase domain TIGR03604 (6/9) thiazole/oxazole-forming peptide maturase, SagD family component PF02624 (6/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (6/9) Nitroreductase family
jaccard_groups_6357	166.79 +- 16.68	2	0	2	0	0.05 +- 0.06	2	10 PF17137 (2/2) Domain of unknown function (DUF5110) PF16338 (2/2) Domain of unknown function (DUF4968) PF13520 (2/2) Amino acid permease PF07730 (2/2) Histidine kinase PF03466 (2/2) LysR substrate binding domain PF01055 (2/2) Glycosyl hydrolases family 31 PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00072 (2/2) Response regulator receiver domain PF00069 (2/2) Protein kinase domain
jaccard_groups_6036	301.83 +- 85.17	2	0	0	2	0.01 +- 0.00	2	7 PF13620 (2/2) Carboxypeptidase regulatory-like domain PF09861 (2/2) Lactate racemase N-terminal domain PF04264 (2/2) YceI-like domain PF00733 (2/2) Asparagine synthase PF00731 (2/2) AIR carboxylase PF00083 (2/2) Sugar (and other) transporter TIGR00268 (1/2) TIGR00268 family protein
jaccard_groups_2768	935.22 +- 296.60	9	0	7	9	0.01 +- 0.00	9	6 TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (9/9) SagB-type dehydrogenase domain PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02517 (9/9) CPBP intramembrane metalloprotease PF00881 (9/9) Nitroreductase family PF00296 (9/9) Luciferase-like monooxygenase
jaccard_groups_2761	1099.00 +- 449.00	3	1	0	0	0.01 +- 0.00	2	6 PF13193 (3/3) AMP-binding enzyme C-terminal domain PF09339 (3/3) IclR helix-turn-helix domain PF01614 (3/3) Bacterial transcriptional regulator PF00501 (3/3) AMP-binding enzyme PF02515 (2/3) CoA-transferase family III PF01144 (2/3) Coenzyme A transferase
jaccard_groups_4106	1105.00 +- 0.00	2	0	0	0	0.02 +- 0.00	2	13 PF16353 (2/2) Domain of unknown function(DUF4981) PF13378 (2/2) Enolase C-terminal domain-like PF13377 (2/2) Periplasmic binding protein-like domain PF06452 (2/2) Carbohydrate family 9 binding domain-like PF02929 (2/2) Beta galactosidase small chain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family
jaccard_groups_2827	232.15 +- 115.15	2	0	0	0	0.02 +- 0.01	2	10 PF09339 (2/2) IclR helix-turn-helix domain PF01614 (2/2) Bacterial transcriptional regulator PF12802 (1/2) MarR family PF12697 (1/2) Alpha/beta hydrolase family PF07883 (1/2) Cupin domain PF07690 (1/2) Major Facilitator Superfamily PF02525 (1/2) Flavodoxin-like fold PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family PF01494 (1/2) FAD binding domain PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
jaccard_groups_470	72.96 +- 100.25	9	0	0	0	0.06 +- 0.08	9	5 PF17866 (9/9) AAA lid domain PF13229 (9/9) Right handed beta helix region PF00652 (9/9) Ricin-type beta-trefoil lectin domain PF00082 (9/9) Subtilase family PF00004 (9/9) ATPase family associated with various cellular activities (AAA)
jaccard_groups_472	773.17 +- 20.67	2	0	0	0	0.01 +- 0.00	2	8 TIGR01926 (2/2) uncharacterized peroxidase-related enzyme PF13454 (2/2) FAD-NAD(P)-binding PF13343 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF02627 (2/2) Carboxymuconolactone decarboxylase family PF01244 (2/2) Membrane dipeptidase (Peptidase family M19) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
jaccard_groups_3804	698.76 +- 460.13	3	0	0	0	0.02 +- 0.03	3	8 PF10502 (3/3) Signal peptidase, peptidase S26 PF03704 (3/3) Bacterial transcriptional activator domain PF00931 (3/3) NB-ARC domain PF00717 (3/3) Peptidase S24-like PF00486 (3/3) Transcriptional regulatory protein, C terminal PF00005 (3/3) ABC transporter PF07291 (2/3) Methylamine utilisation protein MauE PF00899 (2/3) ThiF family
jaccard_groups_5425	800.15 +- 419.49	2	0	0	0	0.03 +- 0.02	2	15 TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF17645 (2/2) Arylmalonate decarboxylase PF09339 (2/2) IclR helix-turn-helix domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF02426 (2/2) Muconolactone delta-isomerase PF01614 (2/2) Bacterial transcriptional regulator PF01593 (2/2) Flavin containing amine oxidoreductase PF01244 (2/2) Membrane dipeptidase (Peptidase family M19) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter PF13489 (1/2) Methyltransferase domain PF05685 (1/2) Putative restriction endonuclease PF04978 (1/2) Protein of unknown function (DUF664)
jaccard_groups_2234	1001.47 +- 887.78	16	0	12	0	0.05 +- 0.18	16	18 PF13535 (16/16) ATP-grasp domain PF13480 (16/16) Acetyltransferase (GNAT) domain PF13115 (16/16) YtkA-like PF04389 (16/16) Peptidase family M28 PF02627 (16/16) Carboxymuconolactone decarboxylase family PF00664 (16/16) ABC transporter transmembrane region PF00403 (16/16) Heavy-metal-associated domain PF00155 (16/16) Aminotransferase class I and II PF00005 (16/16) ABC transporter TIGR01525 (15/16) heavy metal translocating P-type ATPase TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF13549 (15/16) ATP-grasp domain PF01676 (15/16) Metalloenzyme superfamily PF00702 (15/16) haloacid dehalogenase-like hydrolase PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00122 (15/16) E1-E2 ATPase PF00117 (15/16) Glutamine amidotransferase class-I TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
jaccard_groups_4083	30.46 +- 5.65	2	0	0	0	0.07 +- 0.12	2	6 PF17853 (2/2) GGDEF-like domain PF14333 (2/2) Domain of unknown function (DUF4389) PF13556 (2/2) PucR C-terminal helix-turn-helix domain PF08448 (2/2) PAS fold PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF03492 (2/2) SAM dependent carboxyl methyltransferase
jaccard_groups_1584	116.33 +- 25.07	6	0	6	6	0.04 +- 0.04	6	4 TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase PF16715 (6/6) Cyclodipeptide synthase PF00881 (6/6) Nitroreductase family PF00089 (6/6) Trypsin
jaccard_groups_2239	192.15 +- 49.28	3	0	0	0	0.03 +- 0.04	3	4 TIGR01910 (3/3) peptidase, ArgE/DapE family PF01546 (3/3) Peptidase family M20/M25/M40 PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_4327	217.10 +- 169.90	2	0	0	0	0.04 +- 0.10	2	9 TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family PF17964 (2/2) Bacterial Ig domain PF14864 (2/2) Alkyl sulfatase C-terminal PF14863 (2/2) Alkyl sulfatase dimerisation PF08281 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF03734 (2/2) L,D-transpeptidase catalytic domain PF00753 (2/2) Metallo-beta-lactamase superfamily PF00912 (1/2) Transglycosylase
jaccard_groups_1062	855.25 +- 692.75	2	0	1	0	0.02 +- 0.04	2	16 PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF13622 (1/2) Thioesterase-like superfamily PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12697 (1/2) Alpha/beta hydrolase family PF07690 (1/2) Major Facilitator Superfamily PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01636 (1/2) Phosphotransferase enzyme family PF01613 (1/2) Flavin reductase like domain PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00550 (1/2) Phosphopantetheine attachment site PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00106 (1/2) short chain dehydrogenase
jaccard_groups_4424	1191.19 +- 1181.25	4	1	1	4	0.05 +- 0.18	3	22 TIGR03605 (4/4) SagB-type dehydrogenase domain TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF08241 (4/4) Methyltransferase domain PF07993 (4/4) Male sterility protein PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport PF03176 (4/4) MMPL family PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (4/4) Nitroreductase family PF00698 (4/4) Acyl transferase domain PF00550 (4/4) Phosphopantetheine attachment site PF00202 (4/4) Aminotransferase class-III PF00196 (4/4) Bacterial regulatory proteins, luxR family PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain PF03473 (3/4) MOSC domain PF01575 (3/4) MaoC like domain PF00675 (3/4) Insulinase (Peptidase family M16) PF05193 (2/4) Peptidase M16 inactive domain PF03476 (2/4) MOSC N-terminal beta barrel domain PF00106 (2/4) short chain dehydrogenase
jaccard_groups_1497	200.79 +- 26.57	5	0	0	0	0.07 +- 0.11	5	15 TIGR01182 (5/5) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (5/5) Domain of unknown function (DUF4380) PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF13407 (5/5) Periplasmic binding protein domain PF13378 (5/5) Enolase C-terminal domain-like PF08450 (5/5) SMP-30/Gluconolactonase/LRE-like region PF08240 (5/5) Alcohol dehydrogenase GroES-like domain PF07729 (5/5) FCD domain PF02746 (5/5) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (5/5) Branched-chain amino acid transport system / permease component PF01081 (5/5) KDPG and KHG aldolase PF00392 (5/5) Bacterial regulatory proteins, gntR family PF00294 (5/5) pfkB family carbohydrate kinase PF00107 (5/5) Zinc-binding dehydrogenase PF00005 (5/5) ABC transporter
jaccard_groups_608	59.27 +- 22.81	4	0	4	0	0.04 +- 0.07	4	6 PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase PF08241 (4/4) Methyltransferase domain PF04205 (4/4) FMN-binding domain PF02424 (4/4) ApbE family PF01794 (4/4) Ferric reductase like transmembrane component PF00175 (4/4) Oxidoreductase NAD-binding domain
jaccard_groups_601	243.14 +- 234.27	31	0	28	30	0.03 +- 0.04	31	5 PF07690 (31/31) Major Facilitator Superfamily PF04055 (30/31) Radical SAM superfamily PF00326 (28/31) Prolyl oligopeptidase family PF02310 (19/31) B12 binding domain TIGR03975 (16/31) ribosomal peptide maturation radical SAM protein 1
jaccard_groups_604	347.75 +- 199.45	6	0	1	0	0.04 +- 0.06	6	3 PF09084 (6/6) NMT1/THI5 like PF00528 (6/6) Binding-protein-dependent transport system inner membrane component PF00005 (6/6) ABC transporter
jaccard_groups_1669	63.45 +- 1.05	2	0	0	0	0.06 +- 0.06	2	5 PF08220 (2/2) DeoR-like helix-turn-helix domain PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF00455 (2/2) DeoR C terminal sensor domain PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
jaccard_groups_2530	151.10 +- 35.76	3	0	0	0	0.03 +- 0.03	3	6 PF07702 (3/3) UTRA domain PF03747 (3/3) ADP-ribosylglycohydrolase PF02133 (3/3) Permease for cytosine/purines, uracil, thiamine, allantoin PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00294 (3/3) pfkB family carbohydrate kinase PF04672 (2/3) S-adenosyl methyltransferase
jaccard_groups_1943	280.13 +- 235.87	2	0	0	2	0.05 +- 0.16	2	7 PF14518 (2/2) Iron-containing redox enzyme PF12704 (2/2) MacB-like periplasmic core domain PF04055 (2/2) Radical SAM superfamily PF03704 (2/2) Bacterial transcriptional activator domain PF02687 (2/2) FtsX-like permease family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
jaccard_groups_92	934.57 +- 552.23	6	0	1	0	0.03 +- 0.04	6	2 PF01547 (6/6) Bacterial extracellular solute-binding protein PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
jaccard_groups_4557	93.44 +- 9.76	2	0	0	0	0.04 +- 0.07	2	5 PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF03575 (2/2) Peptidase family S51 PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
jaccard_groups_98	355.79 +- 204.29	8	0	0	0	0.07 +- 0.20	8	11 PF00691 (8/8) OmpA family PF00482 (8/8) Type II secretion system (T2SS), protein F PF13400 (7/8) Putative Flp pilus-assembly TadE/G-like PF07730 (7/8) Histidine kinase PF00196 (7/8) Bacterial regulatory proteins, luxR family PF00072 (7/8) Response regulator receiver domain TIGR03177 (6/8) Flp pilus assembly protein CpaB PF16976 (6/8) Flp pilus assembly protein RcpC/CpaB PF13614 (6/8) AAA domain PF07811 (6/8) TadE-like protein PF00437 (6/8) Type II/IV secretion system protein
jaccard_groups_99	136.23 +- 121.23	8	0	0	0	0.05 +- 0.05	8	3 PF00296 (8/8) Luciferase-like monooxygenase PF07690 (5/8) Major Facilitator Superfamily PF00106 (5/8) short chain dehydrogenase
jaccard_groups_4632	322.38 +- 56.79	2	0	0	0	0.02 +- 0.02	2	6 PF09339 (2/2) IclR helix-turn-helix domain PF01614 (2/2) Bacterial transcriptional regulator PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00175 (2/2) Oxidoreductase NAD-binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00067 (2/2) Cytochrome P450
jaccard_groups_694	297.75 +- 125.22	3	0	0	3	0.02 +- 0.03	3	10 TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE PF13186 (3/3) Iron-sulfur cluster-binding domain PF12706 (3/3) Beta-lactamase superfamily domain PF07995 (3/3) Glucose / Sorbosone dehydrogenase PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (3/3) Radical SAM superfamily PF03070 (3/3) TENA/THI-4/PQQC family TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA
jaccard_groups_914	396.80 +- 256.32	12	0	12	0	0.06 +- 0.15	12	16 TIGR03945 (12/12) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (12/12) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01733 (12/12) amino acid adenylation domain PF13193 (12/12) AMP-binding enzyme C-terminal domain PF03621 (12/12) MbtH-like protein PF02423 (12/12) Ornithine cyclodeaminase/mu-crystallin family PF00975 (12/12) Thioesterase domain PF00668 (12/12) Condensation domain PF00550 (12/12) Phosphopantetheine attachment site PF00501 (12/12) AMP-binding enzyme PF00291 (12/12) Pyridoxal-phosphate dependent enzyme TIGR01720 (11/12) non-ribosomal peptide synthase domain TIGR01720 TIGR01188 (11/12) daunorubicin resistance ABC transporter, ATP-binding protein PF01061 (11/12) ABC-2 type transporter PF00005 (11/12) ABC transporter PF13732 (9/12) Domain of unknown function (DUF4162)
jaccard_groups_5629	777.00 +- 3.00	2	0	0	0	0.01 +- 0.00	2	7 PF09339 (2/2) IclR helix-turn-helix domain PF07690 (2/2) Major Facilitator Superfamily PF01614 (2/2) Bacterial transcriptional regulator PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00557 (2/2) Metallopeptidase family M24 PF00355 (2/2) Rieske [2Fe-2S] domain PF00171 (2/2) Aldehyde dehydrogenase family
jaccard_groups_3938	618.09 +- 123.82	5	0	5	5	0.01 +- 0.02	5	15 TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase PF17676 (5/5) LD-carboxypeptidase C-terminal domain PF16715 (5/5) Cyclodipeptide synthase PF13847 (5/5) Methyltransferase domain PF13576 (5/5) Pentapeptide repeats (9 copies) PF13535 (5/5) ATP-grasp domain PF07690 (5/5) Major Facilitator Superfamily PF04055 (5/5) Radical SAM superfamily PF02310 (5/5) B12 binding domain PF02016 (5/5) LD-carboxypeptidase N-terminal domain PF01636 (5/5) Phosphotransferase enzyme family PF00196 (5/5) Bacterial regulatory proteins, luxR family PF00155 (5/5) Aminotransferase class I and II PF00152 (5/5) tRNA synthetases class II (D, K and N) PF00067 (5/5) Cytochrome P450
jaccard_groups_850	167.70 +- 38.70	2	0	0	0	0.01 +- 0.01	2	4 PF12802 (2/2) MarR family PF01261 (2/2) Xylose isomerase-like TIM barrel PF00583 (2/2) Acetyltransferase (GNAT) family PF05977 (1/2) Transmembrane secretion effector
jaccard_groups_3930	194.50 +- 52.12	2	0	0	0	0.07 +- 0.08	2	15 TIGR00976 (2/2) hydrolase CocE/NonD family protein TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family PF13977 (2/2) BetI-type transcriptional repressor, C-terminal PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07690 (2/2) Major Facilitator Superfamily PF04075 (2/2) F420H(2)-dependent quinone reductase PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00005 (2/2) ABC transporter TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
jaccard_groups_324	298.27 +- 161.74	5	0	1	5	0.06 +- 0.08	5	8 TIGR00976 (5/5) hydrolase CocE/NonD family protein PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family) PF00005 (5/5) ABC transporter PF00664 (4/5) ABC transporter transmembrane region PF01497 (3/5) Periplasmic binding protein PF01032 (3/5) FecCD transport family
jaccard_groups_859	261.24 +- 116.32	4	0	4	0	0.02 +- 0.03	4	7 TIGR01746 (4/4) thioester reductase domain PF07993 (4/4) Male sterility protein PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF13193 (3/4) AMP-binding enzyme C-terminal domain PF00300 (3/4) Histidine phosphatase superfamily (branch 1) PF00196 (3/4) Bacterial regulatory proteins, luxR family
jaccard_groups_2998	276.85 +- 62.50	3	0	0	0	0.02 +- 0.02	3	5 PF13924 (3/3) Lipocalin-like domain PF07690 (3/3) Major Facilitator Superfamily PF00857 (3/3) Isochorismatase family PF00171 (3/3) Aldehyde dehydrogenase family PF00082 (2/3) Subtilase family
jaccard_groups_4951	609.27 +- 165.86	3	0	3	0	0.01 +- 0.00	3	11 TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase PF14518 (3/3) Iron-containing redox enzyme PF13378 (3/3) Enolase C-terminal domain-like PF07690 (3/3) Major Facilitator Superfamily PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (3/3) Peptidase family M20/M25/M40 PF01063 (3/3) Amino-transferase class IV PF00682 (3/3) HMGL-like TIGR00035 (2/3) aspartate racemase PF01177 (2/3) Asp/Glu/Hydantoin racemase
jaccard_groups_1200	423.60 +- 111.96	20	0	4	0	0.05 +- 0.16	20	14 TIGR01850 (20/20) N-acetyl-gamma-glutamyl-phosphate reductase PF08443 (20/20) RimK-like ATP-grasp domain PF02779 (20/20) Transketolase, pyrimidine binding domain PF01118 (20/20) Semialdehyde dehydrogenase, NAD binding domain PF00456 (20/20) Transketolase, thiamine diphosphate binding domain TIGR01902 (19/20) N-acetyl-ornithine/N-acetyl-lysine deacetylase PF01546 (19/20) Peptidase family M20/M25/M40 PF01041 (19/20) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (19/20) Amino acid kinase family TIGR00768 (16/20) alpha-L-glutamate ligase, RimK family PF18603 (15/20) L-amino acid ligase C-terminal domain 2 PF18130 (15/20) ATP-grasp N-terminal domain PF13535 (15/20) ATP-grasp domain PF07690 (15/20) Major Facilitator Superfamily
jaccard_groups_1201	304.78 +- 169.03	5	0	0	0	0.02 +- 0.11	5	9 TIGR01554 (5/5) phage major capsid protein, HK97 family TIGR01543 (5/5) phage prohead protease, HK97 family TIGR01537 (5/5) phage portal protein, HK97 family PF05065 (5/5) Phage capsid family PF04860 (5/5) Phage portal protein PF04586 (5/5) Caudovirus prohead serine protease PF01844 (5/5) HNH endonuclease PF01510 (5/5) N-acetylmuramoyl-L-alanine amidase PF09250 (3/5) Bifunctional DNA primase/polymerase, N-terminal
jaccard_groups_5019	143.00 +- 117.00	2	0	0	0	0.04 +- 0.07	2	3 PF09848 (2/2) Uncharacterized conserved protein (DUF2075) PF07728 (2/2) AAA domain (dynein-related subfamily) PF00931 (2/2) NB-ARC domain
jaccard_groups_5018	260.13 +- 5.78	2	0	0	0	0.02 +- 0.01	2	11 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 TIGR00326 (2/2) riboflavin biosynthesis protein RibD PF13641 (2/2) Glycosyltransferase like family 2 PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain PF07690 (2/2) Major Facilitator Superfamily PF07676 (2/2) WD40-like Beta Propeller Repeat PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family PF01872 (2/2) RibD C-terminal domain PF00925 (2/2) GTP cyclohydrolase II PF00400 (2/2) WD domain, G-beta repeat PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
jaccard_groups_4815	129.50 +- 0.50	2	0	1	0	0.02 +- 0.00	2	5 PF12708 (2/2) Pectate lyase superfamily protein PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase PF01120 (2/2) Alpha-L-fucosidase PF00754 (2/2) F5/8 type C domain PF00295 (2/2) Glycosyl hydrolases family 28
jaccard_groups_3439	960.72 +- 458.28	2	0	2	0	0.02 +- 0.02	2	18 PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13191 (2/2) AAA ATPase domain PF08659 (2/2) KR domain PF04820 (2/2) Tryptophan halogenase PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03704 (2/2) Bacterial transcriptional activator domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01613 (2/2) Flavin reductase like domain PF00999 (2/2) Sodium/hydrogen exchanger family PF00975 (2/2) Thioesterase domain PF00931 (2/2) NB-ARC domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00107 (2/2) Zinc-binding dehydrogenase
jaccard_groups_3436	105.42 +- 39.62	3	0	0	0	0.06 +- 0.04	3	10 TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family PF08281 (3/3) Sigma-70, region 4 PF07883 (3/3) Cupin domain PF07690 (3/3) Major Facilitator Superfamily PF04542 (3/3) Sigma-70 region 2 PF01966 (3/3) HD domain TIGR00778 (2/3) alkylhydroperoxidase AhpD family core domain PF08240 (2/3) Alcohol dehydrogenase GroES-like domain PF02627 (2/3) Carboxymuconolactone decarboxylase family PF00107 (2/3) Zinc-binding dehydrogenase
jaccard_groups_823	258.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	2 PF01656 (2/2) CobQ/CobB/MinD/ParA nucleotide binding domain PF01234 (2/2) NNMT/PNMT/TEMT family
jaccard_groups_826	124.87 +- 85.22	5	0	0	0	0.03 +- 0.03	5	5 TIGR01840 (5/5) esterase, PHB depolymerase family TIGR00666 (5/5) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase PF14016 (5/5) Protein of unknown function (DUF4232) PF10503 (5/5) Esterase PHB depolymerase PF02113 (5/5) D-Ala-D-Ala carboxypeptidase 3 (S13) family
jaccard_groups_3322	66.72 +- 9.38	2	0	2	0	0.06 +- 0.01	2	12 TIGR01746 (2/2) thioester reductase domain TIGR01733 (2/2) amino acid adenylation domain PF18130 (2/2) ATP-grasp N-terminal domain PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07993 (2/2) Male sterility protein PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00106 (2/2) short chain dehydrogenase
jaccard_groups_559	532.21 +- 472.81	5	0	2	4	0.02 +- 0.07	5	6 TIGR03882 (4/5) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF07730 (3/5) Histidine kinase PF00196 (3/5) Bacterial regulatory proteins, luxR family PF00072 (3/5) Response regulator receiver domain
jaccard_groups_556	128.36 +- 9.29	2	0	0	0	0.03 +- 0.03	2	8 PF00553 (2/2) Cellulose binding domain PF00150 (2/2) Cellulase (glycosyl hydrolase family 5) PF00041 (2/2) Fibronectin type III domain PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family PF07944 (1/2) Beta-L-arabinofuranosidase, GH127 PF01757 (1/2) Acyltransferase family PF00545 (1/2) ribonuclease

Entry name

Average score

Number of operons

Number of MIBiG operons

Number of operons with antismash overlap

Nr of operons with known RiPP domains

Average COG score

Nr of operons passed filter

Common domains

jaccard_groups_437

1352.84 +- 864.00

0.01 +- 0.01

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02515 (2/2) CoA-transferase family III
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
PF16177 (1/2) Acetyl-coenzyme A synthetase N-terminus
PF13607 (1/2) Succinyl-CoA ligase like flavodoxin domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13531 (1/2) Bacterial extracellular solute-binding protein
PF13380 (1/2) CoA binding domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07729 (1/2) FCD domain
PF07690 (1/2) Major Facilitator Superfamily
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02803 (1/2) Thiolase, C-terminal domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01575 (1/2) MaoC like domain
PF01494 (1/2) FAD binding domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00296 (1/2) Luciferase-like monooxygenase
PF00108 (1/2) Thiolase, N-terminal domain
PF00005 (1/2) ABC transporter

jaccard_groups_114

714.44 +- 930.96

0.03 +- 0.07

PF02983 (4/4) Alpha-lytic protease prodomain
PF00089 (4/4) Trypsin

jaccard_groups_2124

68.58 +- 37.00

0.05 +- 0.03

PF13520 (4/4) Amino acid permease
PF00202 (4/4) Aminotransferase class-III
PF00171 (4/4) Aldehyde dehydrogenase family

jaccard_groups_3027

52.65 +- 10.40

0.06 +- 0.07

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain

jaccard_groups_2120

447.92 +- 197.08

0.01 +- 0.01

PF07993 (2/2) Male sterility protein
PF03756 (2/2) A-factor biosynthesis hotdog domain
PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF00391 (2/2) PEP-utilising enzyme, mobile domain
PF00334 (2/2) Nucleoside diphosphate kinase
PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family

jaccard_groups_6077

226.50 +- 31.50

0.01 +- 0.00

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase

jaccard_groups_3186

43.41 +- 0.41

0.07 +- 0.09

jaccard_groups_1447

1179.64 +- 1207.20

0.05 +- 0.14

TIGR01830 (3/3) 3-oxoacyl-[acyl-carrier-protein] reductase
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF12146 (3/3) Serine aminopeptidase, S33
PF07977 (3/3) FabA-like domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF01323 (3/3) DSBA-like thioredoxin domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF02786 (2/3) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF00698 (2/3) Acyl transferase domain
PF00196 (2/3) Bacterial regulatory proteins, luxR family

jaccard_groups_2909

479.19 +- 156.31

0.02 +- 0.01

jaccard_groups_3611

153.06 +- 34.46

0.06 +- 0.13

TIGR01762 (4/4) chlorinating enzyme
TIGR01733 (4/4) amino acid adenylation domain
TIGR01509 (4/4) HAD hydrolase, family IA, variant 3
TIGR01444 (4/4) methyltransferase, FkbM family
TIGR00843 (4/4) benzoate transporter
PF16990 (4/4) Carbohydrate binding module (family 35)
PF13560 (4/4) Helix-turn-helix domain
PF13535 (4/4) ATP-grasp domain
PF13454 (4/4) FAD-NAD(P)-binding
PF13419 (4/4) Haloacid dehalogenase-like hydrolase
PF13193 (4/4) AMP-binding enzyme C-terminal domain
PF07691 (4/4) PA14 domain
PF06439 (4/4) Domain of Unknown Function (DUF1080)
PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (4/4) Methyltransferase FkbM domain
PF04149 (4/4) Domain of unknown function (DUF397)
PF03594 (4/4) Benzoate membrane transport protein
PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF01116 (4/4) Fructose-bisphosphate aldolase class-II
PF00975 (4/4) Thioesterase domain
PF00892 (4/4) EamA-like transporter family
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain

jaccard_groups_4237

559.06 +- 431.39

0.02 +- 0.04

PF17676 (3/3) LD-carboxypeptidase C-terminal domain
PF13581 (3/3) Histidine kinase-like ATPase domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13280 (3/3) WYL domain
PF08279 (3/3) HTH domain
PF04055 (3/3) Radical SAM superfamily
PF02310 (3/3) B12 binding domain
PF02016 (3/3) LD-carboxypeptidase N-terminal domain
PF00730 (3/3) HhH-GPD superfamily base excision DNA repair protein
PF00293 (3/3) NUDIX domain
PF00152 (3/3) tRNA synthetases class II (D, K and N)
PF00005 (3/3) ABC transporter
PF03372 (2/3) Endonuclease/Exonuclease/phosphatase family

jaccard_groups_177

52.32 +- 21.97

0.05 +- 0.02

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase

jaccard_groups_171

180.52 +- 200.37

0.03 +- 0.04

PF02868 (17/17) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (17/17) Thermolysin metallopeptidase, catalytic domain
PF07504 (15/17) Fungalysin/Thermolysin Propeptide Motif

jaccard_groups_172

131.15 +- 103.02

0.03 +- 0.04

PF11716 (10/10) Mycothiol maleylpyruvate isomerase N-terminal domain
TIGR03083 (9/10) uncharacterized Actinobacterial protein TIGR03083
PF07398 (6/10) MDMPI C-terminal domain

jaccard_groups_173

330.72 +- 274.50

0.05 +- 0.15

PF16197 (18/18) Ketoacyl-synthetase C-terminal extension
PF02801 (18/18) Beta-ketoacyl synthase, C-terminal domain
PF00668 (18/18) Condensation domain
PF00550 (18/18) Phosphopantetheine attachment site
PF00109 (18/18) Beta-ketoacyl synthase, N-terminal domain
TIGR01733 (17/18) amino acid adenylation domain
PF13193 (17/18) AMP-binding enzyme C-terminal domain
PF00698 (17/18) Acyl transferase domain
PF00501 (17/18) AMP-binding enzyme
PF00975 (15/18) Thioesterase domain
PF07690 (10/18) Major Facilitator Superfamily

jaccard_groups_6305

121.07 +- 15.52

0.03 +- 0.05

jaccard_groups_2973

375.44 +- 131.77

0.09 +- 0.21

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF16197 (2/2) Ketoacyl-synthetase C-terminal extension
PF14765 (2/2) Polyketide synthase dehydratase
PF13602 (2/2) Zinc-binding dehydrogenase
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08990 (2/2) Erythronolide synthase docking
PF08659 (2/2) KR domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (2/2) Major Facilitator Superfamily
PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01370 (2/2) NAD dependent epimerase/dehydratase family
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00698 (2/2) Acyl transferase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF00857 (1/2) Isochorismatase family

jaccard_groups_2691

259.00 +- 1.00

0.01 +- 0.00

PF13243 (2/2) Squalene-hopene cyclase C-terminal domain
PF00432 (2/2) Prenyltransferase and squalene oxidase repeat
PF00348 (1/2) Polyprenyl synthetase
PF00293 (1/2) NUDIX domain

jaccard_groups_489

259.00 +- 1.00

0.01 +- 0.00

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

jaccard_groups_642

315.42 +- 243.98

0.03 +- 0.04

TIGR03920 (35/35) type VII secretion integral membrane protein EccD
TIGR03919 (35/35) type VII secretion protein EccB
PF08817 (35/35) WXG100 protein secretion system (Wss), protein YukD
PF05108 (35/35) Type VII secretion system ESX-1, transport TM domain B
PF02575 (34/35) YbaB/EbfC DNA-binding family
PF06013 (29/35) Proteins of 100 residues with WXG
TIGR03930 (26/35) WXG100 family type VII secretion target
PF07179 (20/35) SseB protein N-terminal domain

jaccard_groups_2674

131.54 +- 3.07

0.09 +- 0.06

jaccard_groups_2676

260.26 +- 108.12

0.05 +- 0.03

TIGR04451 (9/9) lantipeptide, SCO0268 family
TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF12802 (9/9) MarR family
PF12697 (9/9) Alpha/beta hydrolase family
PF05147 (9/9) Lanthionine synthetase C-like protein
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF02065 (9/9) Melibiase
PF01547 (9/9) Bacterial extracellular solute-binding protein
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00480 (9/9) ROK family
PF02894 (8/9) Oxidoreductase family, C-terminal alpha/beta domain
PF01408 (8/9) Oxidoreductase family, NAD-binding Rossmann fold

jaccard_groups_5583

129.86 +- 93.00

0.05 +- 0.10

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

jaccard_groups_4356

777.00 +- 3.00

0.01 +- 0.00

jaccard_groups_2472

1010.92 +- 468.30

0.03 +- 0.04

TIGR03812 (4/4) tyrosine decarboxylase MnfA
PF17755 (4/4) UvrA DNA-binding domain
PF16861 (4/4) Carbamoyltransferase C-terminus
PF16169 (4/4) Domain of unknown function (DUF4872)
PF14399 (4/4) Butirosin biosynthesis protein H, N-terminal
PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (4/4) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (4/4) DNA alkylation repair enzyme
PF08241 (4/4) Methyltransferase domain
PF04879 (4/4) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (4/4) Radical SAM superfamily
PF03241 (4/4) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (4/4) Carbamoyltransferase N-terminus
PF02310 (4/4) B12 binding domain
PF02195 (4/4) ParB-like nuclease domain
PF01613 (4/4) Flavin reductase like domain
PF01568 (4/4) Molydopterin dinucleotide binding domain
PF01061 (4/4) ABC-2 type transporter
PF00805 (4/4) Pentapeptide repeats (8 copies)
PF00795 (4/4) Carbon-nitrogen hydrolase
PF00384 (4/4) Molybdopterin oxidoreductase
PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (4/4) ABC transporter
PF00501 (3/4) AMP-binding enzyme

jaccard_groups_5613

135.53 +- 39.47

0.06 +- 0.09

jaccard_groups_289

586.17 +- 706.86

0.02 +- 0.03

TIGR03930 (6/6) WXG100 family type VII secretion target
PF06013 (6/6) Proteins of 100 residues with WXG
TIGR03921 (5/6) type VII secretion-associated serine protease mycosin
PF05108 (5/6) Type VII secretion system ESX-1, transport TM domain B
PF00082 (5/6) Subtilase family
TIGR03919 (4/6) type VII secretion protein EccB

jaccard_groups_5572

533.02 +- 31.35

0.01 +- 0.00

jaccard_groups_795

339.13 +- 0.00

0.03 +- 0.01

jaccard_groups_4775

763.96 +- 609.16

0.05 +- 0.14

jaccard_groups_5270

344.00 +- 86.00

0.01 +- 0.01

jaccard_groups_1652

427.40 +- 123.00

0.03 +- 0.03

TIGR03892 (2/2) thiazolylpeptide-type bacteriocin precursor
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF01959 (2/2) 3-dehydroquinate synthase II
PF01791 (2/2) DeoC/LacD family aldolase
PF01494 (2/2) FAD binding domain
PF00501 (2/2) AMP-binding enzyme

jaccard_groups_3940

1767.52 +- 216.09

0.01 +- 0.02

jaccard_groups_594

215.75 +- 52.67

0.02 +- 0.04

TIGR03086 (4/4) TIGR03086 family protein
PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain
PF01814 (2/4) Hemerythrin HHE cation binding domain

jaccard_groups_4857

152.80 +- 39.15

0.03 +- 0.02

jaccard_groups_5054

224.43 +- 53.86

0.03 +- 0.04

jaccard_groups_5724

766.32 +- 13.68

0.01 +- 0.00

jaccard_groups_50

561.62 +- 388.29

0.01 +- 0.01

PF17853 (2/2) GGDEF-like domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13185 (1/2) GAF domain
PF12770 (1/2) CHAT domain
PF07905 (1/2) Purine catabolism regulatory protein-like family
PF07690 (1/2) Major Facilitator Superfamily
PF01872 (1/2) RibD C-terminal domain
PF01047 (1/2) MarR family
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family

jaccard_groups_52

45.69 +- 30.15

0.07 +- 0.09

TIGR01525 (4/4) heavy metal translocating P-type ATPase
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00122 (4/4) E1-E2 ATPase
PF04314 (3/4) Copper chaperone PCu(A)C
PF00403 (3/4) Heavy-metal-associated domain

jaccard_groups_55

162.82 +- 79.43

0.03 +- 0.03

PF08240 (8/8) Alcohol dehydrogenase GroES-like domain
PF00107 (8/8) Zinc-binding dehydrogenase

jaccard_groups_946

223.40 +- 135.81

0.03 +- 0.04

PF18603 (3/3) L-amino acid ligase C-terminal domain 2
PF13535 (3/3) ATP-grasp domain
PF07690 (3/3) Major Facilitator Superfamily
PF18130 (2/3) ATP-grasp N-terminal domain
PF02668 (2/3) Taurine catabolism dioxygenase TauD, TfdA family
PF00392 (2/3) Bacterial regulatory proteins, gntR family
PF00155 (2/3) Aminotransferase class I and II

jaccard_groups_866

47.52 +- 9.22

0.04 +- 0.05

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2

jaccard_groups_948

1680.69 +- 1143.93

0.04 +- 0.12

PF13649 (5/5) Methyltransferase domain
PF00465 (5/5) Iron-containing alcohol dehydrogenase
PF00202 (5/5) Aminotransferase class-III
PF00005 (5/5) ABC transporter
PF12730 (4/5) ABC-2 family transporter protein
PF00296 (4/5) Luciferase-like monooxygenase
PF00069 (4/5) Protein kinase domain
PF05147 (3/5) Lanthionine synthetase C-like protein

jaccard_groups_864

1319.20 +- 1319.09

0.02 +- 0.04

PF17914 (75/76) HopA1 effector protein family
PF02441 (74/76) Flavoprotein
PF00675 (71/76) Insulinase (Peptidase family M16)
PF00005 (68/76) ABC transporter
PF05193 (67/76) Peptidase M16 inactive domain
PF00296 (61/76) Luciferase-like monooxygenase
PF13649 (43/76) Methyltransferase domain
PF00664 (42/76) ABC transporter transmembrane region
PF01636 (40/76) Phosphotransferase enzyme family

jaccard_groups_3200

400.13 +- 221.16

0.05 +- 0.17

jaccard_groups_219

238.29 +- 148.71

0.03 +- 0.04

PF17900 (2/2) Peptidase M1 N-terminal domain
PF01433 (2/2) Peptidase family M1 domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00293 (1/2) NUDIX domain
PF00067 (1/2) Cytochrome P450

jaccard_groups_216

135.76 +- 125.47

0.04 +- 0.03

PF02776 (4/4) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (4/4) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (4/4) Thiamine pyrophosphate enzyme, central domain
PF07690 (3/4) Major Facilitator Superfamily
PF05721 (2/4) Phytanoyl-CoA dioxygenase (PhyH)
PF00378 (2/4) Enoyl-CoA hydratase/isomerase

jaccard_groups_212

129.71 +- 150.27

0.07 +- 0.07

PF00753 (3/3) Metallo-beta-lactamase superfamily
PF13370 (2/3) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/3) Methyltransferase domain

jaccard_groups_3386

273.84 +- 106.57

0.03 +- 0.01

PF07690 (7/7) Major Facilitator Superfamily
PF05378 (7/7) Hydantoinase/oxoprolinase N-terminal region
PF02538 (7/7) Hydantoinase B/oxoprolinase
PF01968 (7/7) Hydantoinase/oxoprolinase
PF01380 (7/7) SIS domain
PF01019 (7/7) Gamma-glutamyltranspeptidase
PF00294 (7/7) pfkB family carbohydrate kinase

jaccard_groups_3382

111.05 +- 61.85

0.05 +- 0.05

TIGR00350 (5/5) cell envelope-related function transcriptional attenuator common domain
PF13399 (5/5) LytR cell envelope-related transcriptional attenuator
PF07859 (5/5) alpha/beta hydrolase fold
PF03816 (5/5) Cell envelope-related transcriptional attenuator domain
PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent
PF01258 (5/5) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (5/5) D-alanyl-D-alanine carboxypeptidase
PF00459 (5/5) Inositol monophosphatase family

jaccard_groups_6289

1942.50 +- 7.50

0.01 +- 0.00

jaccard_groups_3720

427.75 +- 162.91

0.02 +- 0.01

PF11723 (4/4) Homotrimeric ring hydroxylase
PF02900 (4/4) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (4/4) Peptidase family M20/M25/M40
PF00561 (4/4) alpha/beta hydrolase fold
PF00355 (4/4) Rieske [2Fe-2S] domain
PF00111 (4/4) 2Fe-2S iron-sulfur cluster binding domain
PF12697 (3/4) Alpha/beta hydrolase family
PF00175 (3/4) Oxidoreductase NAD-binding domain

jaccard_groups_6235

2080.00 +- 260.00

0.01 +- 0.00

TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1
TIGR00745 (2/2) 2-dehydropantoate 2-reductase
PF08546 (2/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (2/2) Major Facilitator Superfamily
PF04055 (2/2) Radical SAM superfamily
PF02597 (2/2) ThiS family
PF02558 (2/2) Ketopantoate reductase PanE/ApbA
PF02310 (2/2) B12 binding domain
PF00155 (2/2) Aminotransferase class I and II
PF00067 (2/2) Cytochrome P450
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

jaccard_groups_3370

332.84 +- 267.53

0.06 +- 0.12

jaccard_groups_3371

68.23 +- 18.44

0.05 +- 0.04

TIGR00345 (2/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (2/2) 5TM C-terminal transporter carbon starvation CstA
PF02554 (2/2) Carbon starvation protein CstA
PF02374 (2/2) Anion-transporting ATPase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/2) Sigma-70, region 4

jaccard_groups_500

34.39 +- 12.89

0.09 +- 0.08

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator

jaccard_groups_509

390.00 +- 0.00

0.01 +- 0.00

PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (3/3) Flavin reductase like domain
PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (3/3) Luciferase-like monooxygenase

jaccard_groups_1276

24.19 +- 0.00

0.08 +- 0.03

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme

jaccard_groups_767

151.70 +- 47.50

0.07 +- 0.10

TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF09084 (3/3) NMT1/THI5 like
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
PF09995 (2/3) Uncharacterized protein conserved in bacteria (DUF2236)
PF05719 (2/3) Golgi phosphoprotein 3 (GPP34)

jaccard_groups_761

729.04 +- 362.80

0.05 +- 0.11

TIGR04364 (9/9) methyltransferase, FxLD system
TIGR04363 (9/9) FxLD family lantipeptide
TIGR03891 (9/9) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (9/9) Lantibiotic biosynthesis dehydratase C-term
PF05331 (9/9) Protein of unknown function (DUF742)
PF05147 (9/9) Lanthionine synthetase C-like protein
PF04738 (9/9) Lantibiotic dehydratase, N terminus
PF03259 (9/9) Roadblock/LC7 domain
PF03029 (9/9) Conserved hypothetical ATP binding protein
PF01135 (9/9) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (9/9) NUDIX domain
PF00196 (9/9) Bacterial regulatory proteins, luxR family
PF00005 (9/9) ABC transporter
PF02771 (7/9) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (7/9) Acyl-CoA dehydrogenase, middle domain
PF01590 (7/9) GAF domain
PF01427 (7/9) D-ala-D-ala dipeptidase
PF00441 (7/9) Acyl-CoA dehydrogenase, C-terminal domain
PF00723 (5/9) Glycosyl hydrolases family 15

jaccard_groups_763

1162.04 +- 959.64

0.03 +- 0.08

PF00005 (85/85) ABC transporter
PF13575 (84/85) Domain of unknown function (DUF4135)
PF05147 (84/85) Lanthionine synthetase C-like protein
PF00664 (84/85) ABC transporter transmembrane region
PF03412 (83/85) Peptidase C39 family
TIGR03897 (79/85) type 2 lantibiotic biosynthesis protein LanM
PF14867 (43/85) Lantibiotic alpha

jaccard_groups_139

331.74 +- 178.03

0.02 +- 0.02

PF02780 (5/5) Transketolase, C-terminal domain
PF00676 (5/5) Dehydrogenase E1 component
PF00364 (5/5) Biotin-requiring enzyme
PF00198 (5/5) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PF02779 (4/5) Transketolase, pyrimidine binding domain
PF08545 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (3/5) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF00550 (3/5) Phosphopantetheine attachment site

jaccard_groups_1879

1882.17 +- 1757.83

0.05 +- 0.07

PF14310 (2/2) Fibronectin type III-like domain
PF13416 (2/2) Bacterial extracellular solute-binding protein
PF13377 (2/2) Periplasmic binding protein-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain
PF13802 (1/2) Galactose mutarotase-like
PF08244 (1/2) Glycosyl hydrolases family 32 C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01833 (1/2) IPT/TIG domain
PF01055 (1/2) Glycosyl hydrolases family 31
PF00754 (1/2) F5/8 type C domain
PF00251 (1/2) Glycosyl hydrolases family 32 N-terminal domain

jaccard_groups_6462

50.96 +- 10.96

0.06 +- 0.07

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

jaccard_groups_3129

864.29 +- 155.78

0.01 +- 0.02

jaccard_groups_3796

214.87 +- 119.93

0.02 +- 0.03

PF05901 (4/4) Excalibur calcium-binding domain
PF01738 (4/4) Dienelactone hydrolase family
PF00293 (4/4) NUDIX domain
PF00067 (2/4) Cytochrome P450

jaccard_groups_6512

101.28 +- 23.28

0.05 +- 0.10

jaccard_groups_2010

142.50 +- 52.50

0.05 +- 0.07

TIGR00167 (2/2) ketose-bisphosphate aldolase
PF17042 (2/2) Nucleotide-binding C-terminal domain
PF14833 (2/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF07729 (2/2) FCD domain
PF07005 (2/2) Sugar-binding N-terminal domain
PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (2/2) GntP family permease
PF01116 (2/2) Fructose-bisphosphate aldolase class-II
PF00392 (2/2) Bacterial regulatory proteins, gntR family
TIGR00791 (1/2) transporter, gluconate:H+ symporter (GntP) family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13407 (1/2) Periplasmic binding protein domain
PF13185 (1/2) GAF domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF01614 (1/2) Bacterial transcriptional regulator
PF00775 (1/2) Dioxygenase

jaccard_groups_3159

284.37 +- 95.70

0.03 +- 0.05

PF12833 (5/5) Helix-turn-helix domain
PF02774 (5/5) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (5/5) DJ-1/PfpI family
PF01118 (5/5) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (5/5) Amino acid kinase family
PF00196 (5/5) Bacterial regulatory proteins, luxR family
PF00171 (5/5) Aldehyde dehydrogenase family
PF00465 (4/5) Iron-containing alcohol dehydrogenase

jaccard_groups_2206

139.29 +- 9.29

0.03 +- 0.02

PF13460 (2/2) NAD(P)H-binding
PF00561 (2/2) alpha/beta hydrolase fold
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01494 (1/2) FAD binding domain

jaccard_groups_1473

113.82 +- 0.00

0.08 +- 0.05

PF13378 (2/2) Enolase C-terminal domain-like
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00701 (2/2) Dihydrodipicolinate synthetase family
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF04203 (1/2) Sortase domain

jaccard_groups_1478

1029.59 +- 549.79

0.03 +- 0.03

PF13471 (5/5) Transglutaminase-like superfamily
PF05402 (5/5) Coenzyme PQQ synthesis protein D (PqqD)
PF01061 (5/5) ABC-2 type transporter
PF00733 (5/5) Asparagine synthase
PF00005 (5/5) ABC transporter
TIGR01188 (3/5) daunorubicin resistance ABC transporter, ATP-binding protein
PF13462 (3/5) Thioredoxin
PF07730 (3/5) Histidine kinase
PF00196 (3/5) Bacterial regulatory proteins, luxR family
PF00072 (3/5) Response regulator receiver domain

jaccard_groups_997

144.69 +- 113.31

0.04 +- 0.06

PF18593 (2/2) CdiI immunity protein
PF18431 (2/2) Bacterial CdiA-CT RNAse A domain
PF13560 (2/2) Helix-turn-helix domain
PF06013 (2/2) Proteins of 100 residues with WXG
PF04149 (2/2) Domain of unknown function (DUF397)

jaccard_groups_994

250.84 +- 78.71

0.03 +- 0.11

TIGR01558 (6/6) putative phage terminase, small subunit, P27 family
TIGR01554 (6/6) phage major capsid protein, HK97 family
TIGR01543 (6/6) phage prohead protease, HK97 family
TIGR01537 (6/6) phage portal protein, HK97 family
PF10145 (6/6) Phage-related minor tail protein
PF05119 (6/6) Phage terminase, small subunit
PF05065 (6/6) Phage capsid family
PF04860 (6/6) Phage portal protein
PF04586 (6/6) Caudovirus prohead serine protease
PF03354 (6/6) Phage Terminase
PF01510 (6/6) N-acetylmuramoyl-L-alanine amidase
PF01381 (6/6) Helix-turn-helix
PF16945 (4/6) Putative lactococcus lactis phage r1t holin
PF13229 (4/6) Right handed beta helix region
PF01476 (4/6) LysM domain
PF01464 (4/6) Transglycosylase SLT domain

jaccard_groups_5913

647.50 +- 2.50

0.01 +- 0.00

jaccard_groups_993

66.40 +- 35.34

0.06 +- 0.08

PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF07690 (2/2) Major Facilitator Superfamily
PF03771 (2/2) Domain of unknown function (DUF317)
PF01638 (2/2) HxlR-like helix-turn-helix
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF16259 (1/2) Domain of unknown function (DUF4913)
PF13649 (1/2) Methyltransferase domain
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF12307 (1/2) Protein of unknown function (DUF3631)
PF08239 (1/2) Bacterial SH3 domain
PF01555 (1/2) DNA methylase

jaccard_groups_4482

1855.31 +- 282.62

0.04 +- 0.15

jaccard_groups_4093

886.61 +- 688.91

0.03 +- 0.01

TIGR03561 (3/3) peroxiredoxin, Ohr subfamily
PF13649 (3/3) Methyltransferase domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF09339 (3/3) IclR helix-turn-helix domain
PF09084 (3/3) NMT1/THI5 like
PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF02566 (3/3) OsmC-like protein
PF01614 (3/3) Bacterial transcriptional regulator
PF01546 (3/3) Peptidase family M20/M25/M40
PF00724 (3/3) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (3/3) alpha/beta hydrolase fold
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00005 (3/3) ABC transporter
PF04199 (2/3) Putative cyclase
PF03972 (2/3) MmgE/PrpD family
PF03328 (2/3) HpcH/HpaI aldolase/citrate lyase family
PF02515 (2/3) CoA-transferase family III
PF01979 (2/3) Amidohydrolase family

jaccard_groups_4722

146.32 +- 79.43

0.04 +- 0.06

jaccard_groups_5898

600.85 +- 188.32

0.03 +- 0.04

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00738 (2/2) Rrf2 family protein
PF18364 (2/2) Molybdopterin oxidoreductase N-terminal domain
PF13743 (2/2) Thioredoxin
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF02082 (2/2) Transcriptional regulator
PF01613 (2/2) Flavin reductase like domain
PF01568 (2/2) Molydopterin dinucleotide binding domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00384 (2/2) Molybdopterin oxidoreductase
PF00296 (2/2) Luciferase-like monooxygenase
PF00005 (2/2) ABC transporter
PF13427 (1/2) Domain of unknown function (DUF4111)
PF12146 (1/2) Serine aminopeptidase, S33
PF08386 (1/2) TAP-like protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF01909 (1/2) Nucleotidyltransferase domain

jaccard_groups_1054

156.96 +- 65.90

0.02 +- 0.03

jaccard_groups_1976

100.79 +- 5.13

0.06 +- 0.07

jaccard_groups_2336

40.24 +- 11.75

0.08 +- 0.17

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C

jaccard_groups_1114

241.84 +- 175.07

0.05 +- 0.05

PF16353 (6/6) Domain of unknown function(DUF4981)
PF02929 (6/6) Beta galactosidase small chain
PF02837 (6/6) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (6/6) Glycosyl hydrolases family 2, TIM barrel domain
PF00703 (4/6) Glycosyl hydrolases family 2
PF13385 (3/6) Concanavalin A-like lectin/glucanases superfamily
PF09995 (3/6) Uncharacterized protein conserved in bacteria (DUF2236)
PF01547 (3/6) Bacterial extracellular solute-binding protein
PF01074 (3/6) Glycosyl hydrolases family 38 N-terminal domain
PF00528 (3/6) Binding-protein-dependent transport system inner membrane component

jaccard_groups_2849

98.93 +- 27.86

0.05 +- 0.05

jaccard_groups_4006

502.26 +- 347.48

0.05 +- 0.18

jaccard_groups_1505

104.64 +- 38.90

0.06 +- 0.07

jaccard_groups_618

32.06 +- 9.93

0.07 +- 0.05

jaccard_groups_610

172.00 +- 34.40

0.02 +- 0.03

PF00891 (2/2) O-methyltransferase domain
PF16864 (1/2) Dimerisation domain
PF13649 (1/2) Methyltransferase domain
PF05090 (1/2) Vitamin K-dependent gamma-carboxylase
PF01212 (1/2) Beta-eliminating lyase

jaccard_groups_616

226.60 +- 172.94

0.03 +- 0.04

PF13649 (7/7) Methyltransferase domain
PF00005 (7/7) ABC transporter
PF12697 (5/7) Alpha/beta hydrolase family
PF13450 (4/7) NAD(P)-binding Rossmann-like domain
PF00664 (4/7) ABC transporter transmembrane region

jaccard_groups_2522

637.59 +- 4.54

0.03 +- 0.02

TIGR00928 (2/2) adenylosuccinate lyase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (2/2) Acetyltransferase (GNAT) domain
PF13460 (2/2) NAD(P)H-binding
PF12800 (2/2) 4Fe-4S binding domain
PF07690 (2/2) Major Facilitator Superfamily
PF01814 (2/2) Hemerythrin HHE cation binding domain
PF01494 (2/2) FAD binding domain
PF01425 (2/2) Amidase
PF00561 (2/2) alpha/beta hydrolase fold
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00206 (2/2) Lyase
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00072 (2/2) Response regulator receiver domain

jaccard_groups_5316

182.05 +- 34.62

0.02 +- 0.02

jaccard_groups_4266

179.53 +- 21.38

0.08 +- 0.15

jaccard_groups_61

94.60 +- 8.60

0.02 +- 0.02

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF18029 (1/2) Glyoxalase-like domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00156 (1/2) Phosphoribosyl transferase domain

jaccard_groups_5094

154.25 +- 11.20

0.05 +- 0.16

jaccard_groups_18

38.61 +- 19.66

0.07 +- 0.07

PF00271 (3/3) Helicase conserved C-terminal domain
PF00270 (3/3) DEAD/DEAH box helicase
PF10923 (2/3) P-loop Domain of unknown function (DUF2791)
PF09848 (2/3) Uncharacterized conserved protein (DUF2075)

jaccard_groups_19

138.16 +- 77.48

0.05 +- 0.10

PF07228 (7/8) Stage II sporulation protein E (SpoIIE)
PF08448 (6/8) PAS fold
TIGR00229 (5/8) PAS domain S-box protein
PF13581 (5/8) Histidine kinase-like ATPase domain
PF13185 (4/8) GAF domain

jaccard_groups_14

412.84 +- 268.06

0.03 +- 0.04

PF13377 (10/10) Periplasmic binding protein-like domain
PF00356 (10/10) Bacterial regulatory proteins, lacI family
PF00528 (7/10) Binding-protein-dependent transport system inner membrane component
PF02065 (6/10) Melibiase
PF00266 (6/10) Aminotransferase class-V
PF13416 (5/10) Bacterial extracellular solute-binding protein

jaccard_groups_1609

164.29 +- 96.60

0.05 +- 0.04

TIGR03217 (9/9) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (9/9) acetaldehyde dehydrogenase (acetylating)
PF13621 (9/9) Cupin-like domain
PF09290 (9/9) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (9/9) DmpG-like communication domain
PF07690 (9/9) Major Facilitator Superfamily
PF03328 (9/9) HpcH/HpaI aldolase/citrate lyase family
PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (9/9) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (9/9) HMGL-like
PF00155 (9/9) Aminotransferase class I and II

jaccard_groups_16

107.91 +- 40.97

0.05 +- 0.04

PF03466 (3/3) LysR substrate binding domain
PF00126 (3/3) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_1975

343.46 +- 204.82

0.02 +- 0.04

PF13191 (9/9) AAA ATPase domain
PF00211 (9/9) Adenylate and Guanylate cyclase catalytic domain
PF00082 (9/9) Subtilase family
PF13185 (8/9) GAF domain
PF04055 (8/9) Radical SAM superfamily
PF14518 (5/9) Iron-containing redox enzyme

jaccard_groups_10

281.67 +- 272.44

0.04 +- 0.08

PF03704 (5/6) Bacterial transcriptional activator domain
PF00486 (5/6) Transcriptional regulatory protein, C terminal
PF00931 (4/6) NB-ARC domain
PF13424 (3/6) Tetratricopeptide repeat
PF00082 (3/6) Subtilase family

jaccard_groups_11

230.60 +- 200.58

0.05 +- 0.09

PF02518 (12/12) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00512 (12/12) His Kinase A (phospho-acceptor) domain
PF00486 (12/12) Transcriptional regulatory protein, C terminal
PF00072 (12/12) Response regulator receiver domain
PF00672 (11/12) HAMP domain

jaccard_groups_3908

1645.66 +- 1357.34

0.05 +- 0.19

TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family
TIGR00761 (2/2) acetylglutamate kinase
PF14399 (2/2) Butirosin biosynthesis protein H, N-terminal
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08443 (2/2) RimK-like ATP-grasp domain
PF05977 (2/2) Transmembrane secretion effector
PF02780 (2/2) Transketolase, C-terminal domain
PF02779 (2/2) Transketolase, pyrimidine binding domain
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (2/2) Thioesterase domain
PF00696 (2/2) Amino acid kinase family
PF00668 (2/2) Condensation domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00456 (2/2) Transketolase, thiamine diphosphate binding domain
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR02039 (1/2) sulfate adenylyltransferase, small subunit
TIGR02034 (1/2) sulfate adenylyltransferase, large subunit
TIGR00455 (1/2) adenylyl-sulfate kinase
PF18029 (1/2) Glyoxalase-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01583 (1/2) Adenylylsulphate kinase
PF01507 (1/2) Phosphoadenosine phosphosulfate reductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00326 (1/2) Prolyl oligopeptidase family
PF00009 (1/2) Elongation factor Tu GTP binding domain

jaccard_groups_1501

120.00 +- 0.00

0.10 +- 0.25

jaccard_groups_5008

765.63 +- 127.45

0.01 +- 0.01

jaccard_groups_5003

650.00 +- 0.00

0.02 +- 0.00

jaccard_groups_4865

738.11 +- 238.15

0.01 +- 0.01

jaccard_groups_1232

71.67 +- 26.71

0.06 +- 0.07

PF14534 (5/5) Domain of unknown function (DUF4440)
PF08002 (5/5) Protein of unknown function (DUF1697)
PF05922 (5/5) Peptidase inhibitor I9
PF00082 (5/5) Subtilase family

jaccard_groups_3541

108.35 +- 37.40

0.09 +- 0.06

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

jaccard_groups_3340

371.41 +- 284.77

0.03 +- 0.08

jaccard_groups_6243

107.29 +- 28.50

0.04 +- 0.04

jaccard_groups_4892

1018.46 +- 114.56

0.01 +- 0.00

jaccard_groups_800

90.32 +- 12.32

0.03 +- 0.02

PF14759 (2/2) Reductase C-terminal
PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF14518 (1/2) Iron-containing redox enzyme
PF00083 (1/2) Sugar (and other) transporter

jaccard_groups_4890

1430.00 +- 130.00

0.01 +- 0.00

jaccard_groups_4895

151.88 +- 91.88

0.04 +- 0.05

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF07690 (2/2) Major Facilitator Superfamily
PF04309 (2/2) Glycerol-3-phosphate responsive antiterminator
PF02913 (2/2) FAD linked oxidases, C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (2/2) FAD binding domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF13333 (1/2) Integrase core domain
PF13276 (1/2) HTH-like domain
PF01527 (1/2) Transposase
PF00665 (1/2) Integrase core domain

jaccard_groups_677

115.84 +- 70.48

0.03 +- 0.05

PF13537 (5/5) Glutamine amidotransferase domain
PF00733 (5/5) Asparagine synthase
PF00171 (3/5) Aldehyde dehydrogenase family

jaccard_groups_546

169.85 +- 94.28

0.04 +- 0.04

PF03033 (4/4) Glycosyltransferase family 28 N-terminal domain
PF00201 (4/4) UDP-glucoronosyl and UDP-glucosyl transferase
PF00756 (3/4) Putative esterase

jaccard_groups_269

271.71 +- 249.02

0.04 +- 0.07

PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family)
TIGR00976 (6/8) hydrolase CocE/NonD family protein

jaccard_groups_402

569.24 +- 406.57

0.05 +- 0.06

PF08532 (4/4) Beta-galactosidase trimerisation domain
PF02449 (4/4) Beta-galactosidase
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF08533 (3/4) Beta-galactosidase C-terminal domain
PF01547 (3/4) Bacterial extracellular solute-binding protein

jaccard_groups_6019

1040.00 +- 0.00

0.01 +- 0.00

jaccard_groups_2069

77.88 +- 16.58

0.08 +- 0.04

TIGR02133 (6/6) ribose 5-phosphate isomerase
PF16896 (6/6) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (6/6) Major Facilitator Superfamily
PF03807 (6/6) NADP oxidoreductase coenzyme F420-dependent
PF02734 (6/6) DAK2 domain
PF02733 (6/6) Dak1 domain
PF02502 (6/6) Ribose/Galactose Isomerase
PF01261 (6/6) Xylose isomerase-like TIM barrel
PF00121 (6/6) Triosephosphate isomerase

jaccard_groups_2068

249.70 +- 143.29

0.05 +- 0.05

jaccard_groups_2064

359.93 +- 257.30

0.04 +- 0.07

jaccard_groups_3164

378.11 +- 182.20

0.02 +- 0.03

PF13450 (6/6) NAD(P)-binding Rossmann-like domain
PF07690 (6/6) Major Facilitator Superfamily
PF05721 (6/6) Phytanoyl-CoA dioxygenase (PhyH)
PF02668 (6/6) Taurine catabolism dioxygenase TauD, TfdA family
PF00348 (6/6) Polyprenyl synthetase
PF00106 (6/6) short chain dehydrogenase
PF00743 (5/6) Flavin-binding monooxygenase-like
TIGR01534 (4/6) glyceraldehyde-3-phosphate dehydrogenase, type I
PF02800 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF00044 (4/6) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

jaccard_groups_3690

215.27 +- 98.42

0.04 +- 0.05

TIGR02937 (5/5) RNA polymerase sigma factor, sigma-70 family
PF10025 (5/5) Uncharacterized conserved protein (DUF2267)
PF08281 (5/5) Sigma-70, region 4
PF04542 (5/5) Sigma-70 region 2
PF00355 (5/5) Rieske [2Fe-2S] domain
PF00067 (5/5) Cytochrome P450
TIGR03975 (4/5) ribosomal peptide maturation radical SAM protein 1
PF07690 (4/5) Major Facilitator Superfamily
PF04055 (4/5) Radical SAM superfamily
PF02310 (4/5) B12 binding domain
PF00326 (4/5) Prolyl oligopeptidase family

jaccard_groups_3647

447.82 +- 139.46

0.06 +- 0.21

PF17914 (3/3) HopA1 effector protein family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02441 (3/3) Flavoprotein
PF01636 (3/3) Phosphotransferase enzyme family
PF00326 (3/3) Prolyl oligopeptidase family
PF00296 (3/3) Luciferase-like monooxygenase
PF07730 (2/3) Histidine kinase
PF01061 (2/3) ABC-2 type transporter
PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00072 (2/3) Response regulator receiver domain
PF00005 (2/3) ABC transporter

jaccard_groups_104

29.41 +- 3.34

0.08 +- 0.06

PF13602 (3/3) Zinc-binding dehydrogenase
PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00106 (2/3) short chain dehydrogenase

jaccard_groups_3587

187.56 +- 79.93

0.03 +- 0.04

jaccard_groups_6495

64.13 +- 5.87

0.06 +- 0.13

jaccard_groups_3568

491.70 +- 429.24

0.02 +- 0.05

jaccard_groups_163

146.25 +- 113.75

0.03 +- 0.05

PF05685 (2/2) Putative restriction endonuclease
PF05016 (1/2) ParE toxin of type II toxin-antitoxin system, parDE
PF04149 (1/2) Domain of unknown function (DUF397)
PF00583 (1/2) Acetyltransferase (GNAT) family

jaccard_groups_2368

94.90 +- 28.28

0.04 +- 0.02

jaccard_groups_160

258.67 +- 0.94

0.01 +- 0.00

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family

jaccard_groups_1491

1089.57 +- 871.67

0.01 +- 0.00

PF03412 (7/7) Peptidase C39 family
PF00668 (7/7) Condensation domain
PF00664 (7/7) ABC transporter transmembrane region
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00005 (7/7) ABC transporter

jaccard_groups_165

144.63 +- 101.54

0.04 +- 0.04

TIGR03026 (4/4) nucleotide sugar dehydrogenase
PF03721 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF00984 (4/4) UDP-glucose/GDP-mannose dehydrogenase family, central domain
TIGR00711 (2/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF07690 (2/4) Major Facilitator Superfamily
PF00201 (2/4) UDP-glucoronosyl and UDP-glucosyl transferase

jaccard_groups_3769

240.97 +- 100.44

0.02 +- 0.02

PF12697 (3/3) Alpha/beta hydrolase family
PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (3/3) Prolyl oligopeptidase family
PF00313 (3/3) 'Cold-shock' DNA-binding domain
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00069 (3/3) Protein kinase domain

jaccard_groups_2360

197.13 +- 83.31

0.02 +- 0.02

PF12833 (2/2) Helix-turn-helix domain
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (2/2) DJ-1/PfpI family
PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
TIGR03446 (1/2) mycothiol conjugate amidase Mca
PF07859 (1/2) alpha/beta hydrolase fold
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01494 (1/2) FAD binding domain

jaccard_groups_1785

273.52 +- 225.37

0.03 +- 0.07

PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (4/4) SPFH domain / Band 7 family
PF00877 (4/4) NlpC/P60 family

jaccard_groups_2807

154.14 +- 79.86

0.02 +- 0.03

PF13602 (2/2) Zinc-binding dehydrogenase
PF13564 (2/2) DoxX-like family
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF00296 (2/2) Luciferase-like monooxygenase
PF00106 (2/2) short chain dehydrogenase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13460 (1/2) NAD(P)H-binding
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)

jaccard_groups_2804

419.05 +- 139.95

0.01 +- 0.00

jaccard_groups_1424

383.25 +- 193.13

0.02 +- 0.06

PF07291 (12/12) Methylamine utilisation protein MauE
PF00717 (12/12) Peptidase S24-like
PF00005 (12/12) ABC transporter
PF00578 (9/12) AhpC/TSA family
PF10502 (6/12) Signal peptidase, peptidase S26

jaccard_groups_1397

799.92 +- 505.57

0.02 +- 0.07

TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (9/9) SagB-type dehydrogenase domain
TIGR03604 (9/9) thiazole/oxazole-forming peptide maturase, SagD family component
PF03412 (9/9) Peptidase C39 family
PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (9/9) Nitroreductase family
PF00664 (9/9) ABC transporter transmembrane region
PF00005 (9/9) ABC transporter
PF13575 (8/9) Domain of unknown function (DUF4135)
PF00067 (8/9) Cytochrome P450
PF00364 (6/9) Biotin-requiring enzyme

jaccard_groups_5864

80.77 +- 3.37

0.06 +- 0.08

jaccard_groups_1544

41.61 +- 0.00

0.10 +- 0.09

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (2/2) Major Facilitator Superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450

jaccard_groups_719

282.54 +- 181.38

0.03 +- 0.05

PF07739 (8/8) TipAS antibiotic-recognition domain
PF07228 (8/8) Stage II sporulation protein E (SpoIIE)
PF13411 (7/8) MerR HTH family regulatory protein
PF07690 (6/8) Major Facilitator Superfamily
PF01551 (6/8) Peptidase family M23
PF00291 (6/8) Pyridoxal-phosphate dependent enzyme

jaccard_groups_8

552.00 +- 588.46

0.03 +- 0.05

PF00005 (44/44) ABC transporter
PF00664 (41/44) ABC transporter transmembrane region
PF00069 (38/44) Protein kinase domain
PF05147 (30/44) Lanthionine synthetase C-like protein
PF00326 (25/44) Prolyl oligopeptidase family
PF04672 (23/44) S-adenosyl methyltransferase

jaccard_groups_9

133.85 +- 102.99

0.03 +- 0.04

PF00069 (5/5) Protein kinase domain

jaccard_groups_4

163.62 +- 122.15

0.04 +- 0.05

PF07690 (7/7) Major Facilitator Superfamily

jaccard_groups_5

171.61 +- 154.50

0.07 +- 0.12

PF08281 (3/3) Sigma-70, region 4
PF04542 (3/3) Sigma-70 region 2
TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family

jaccard_groups_2

376.95 +- 80.35

0.01 +- 0.00

PF00440 (5/5) Bacterial regulatory proteins, tetR family

jaccard_groups_3

243.73 +- 166.49

0.03 +- 0.08

PF07730 (19/19) Histidine kinase
PF00196 (19/19) Bacterial regulatory proteins, luxR family
PF00072 (19/19) Response regulator receiver domain

jaccard_groups_3864

150.05 +- 8.21

0.09 +- 0.23

TIGR03144 (2/2) cytochrome c-type biogenesis protein CcsB
TIGR01525 (2/2) heavy metal translocating P-type ATPase
TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13462 (2/2) Thioredoxin
PF07884 (2/2) Vitamin K epoxide reductase family
PF07690 (2/2) Major Facilitator Superfamily
PF05140 (2/2) ResB-like family
PF02683 (2/2) Cytochrome C biogenesis protein transmembrane region
PF01758 (2/2) Sodium Bile acid symporter family
PF01578 (2/2) Cytochrome C assembly protein
PF01545 (2/2) Cation efflux family
PF01252 (2/2) Signal peptidase (SPase) II
PF01022 (2/2) Bacterial regulatory protein, arsR family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00578 (2/2) AhpC/TSA family
PF00122 (2/2) E1-E2 ATPase
TIGR01573 (1/2) CRISPR-associated endonuclease Cas2
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF13411 (1/2) MerR HTH family regulatory protein
PF12833 (1/2) Helix-turn-helix domain
PF10825 (1/2) Protein of unknown function (DUF2752)
PF09827 (1/2) CRISPR associated protein Cas2
PF02630 (1/2) SCO1/SenC
PF00795 (1/2) Carbon-nitrogen hydrolase

jaccard_groups_2565

345.37 +- 304.63

0.02 +- 0.03

PF00082 (2/2) Subtilase family
PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF13517 (1/2) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF13191 (1/2) AAA ATPase domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF03704 (1/2) Bacterial transcriptional activator domain

jaccard_groups_293

149.38 +- 100.19

0.02 +- 0.02

PF14759 (7/8) Reductase C-terminal
PF13370 (7/8) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (7/8) Pyridine nucleotide-disulphide oxidoreductase
PF00903 (5/8) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

jaccard_groups_5605

705.83 +- 204.17

0.01 +- 0.01

jaccard_groups_69

42.23 +- 13.81

0.06 +- 0.04

PF00248 (3/3) Aldo/keto reductase family
PF08007 (2/3) Cupin superfamily protein

jaccard_groups_1160

605.32 +- 462.85

0.07 +- 0.11

TIGR01733 (23/23) amino acid adenylation domain
PF13193 (23/23) AMP-binding enzyme C-terminal domain
PF10862 (23/23) FcoT-like thioesterase domain
PF08545 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (23/23) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (23/23) Male sterility protein
PF07690 (23/23) Major Facilitator Superfamily
PF05118 (23/23) Aspartyl/Asparaginyl beta-hydroxylase
PF02668 (23/23) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (23/23) Condensation domain
PF00550 (23/23) Phosphopantetheine attachment site
PF00501 (23/23) AMP-binding enzyme
TIGR01746 (22/23) thioester reductase domain
TIGR01525 (22/23) heavy metal translocating P-type ATPase
TIGR00747 (22/23) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF04314 (22/23) Copper chaperone PCu(A)C
PF00702 (22/23) haloacid dehalogenase-like hydrolase
PF00403 (22/23) Heavy-metal-associated domain
PF00122 (22/23) E1-E2 ATPase
PF01497 (21/23) Periplasmic binding protein
PF01032 (21/23) FecCD transport family
PF00005 (21/23) ABC transporter
PF01965 (19/23) DJ-1/PfpI family

jaccard_groups_22

134.76 +- 86.38

0.04 +- 0.07

PF12802 (2/2) MarR family
PF01965 (2/2) DJ-1/PfpI family
PF00069 (2/2) Protein kinase domain

jaccard_groups_4291

227.25 +- 162.75

0.03 +- 0.05

TIGR01840 (2/2) esterase, PHB depolymerase family
PF10503 (2/2) Esterase PHB depolymerase
PF08223 (2/2) PaaX-like protein C-terminal domain
PF07848 (2/2) PaaX-like protein
PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00553 (2/2) Cellulose binding domain
PF00331 (2/2) Glycosyl hydrolase family 10

jaccard_groups_199

250.40 +- 9.60

0.02 +- 0.02

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

jaccard_groups_222

1424.71 +- 886.93

0.02 +- 0.05

PF07811 (4/4) TadE-like protein
PF00482 (4/4) Type II secretion system (T2SS), protein F
PF00437 (4/4) Type II/IV secretion system protein
PF13400 (3/4) Putative Flp pilus-assembly TadE/G-like
PF08666 (3/4) SAF domain
PF01476 (3/4) LysM domain
PF14081 (2/4) Domain of unknown function (DUF4262)
PF03704 (2/4) Bacterial transcriptional activator domain
PF01381 (2/4) Helix-turn-helix

jaccard_groups_2414

122.10 +- 43.38

0.05 +- 0.04

jaccard_groups_5043

760.47 +- 374.44

0.04 +- 0.12

jaccard_groups_60

278.98 +- 192.79

0.02 +- 0.04

PF00082 (15/15) Subtilase family

jaccard_groups_5049

388.00 +- 128.00

0.01 +- 0.00

jaccard_groups_25

108.15 +- 115.79

0.06 +- 0.06

PF05331 (8/8) Protein of unknown function (DUF742)
PF03259 (8/8) Roadblock/LC7 domain
PF03029 (8/8) Conserved hypothetical ATP binding protein
PF00067 (8/8) Cytochrome P450
PF04149 (6/8) Domain of unknown function (DUF397)

jaccard_groups_26

115.49 +- 100.95

0.04 +- 0.04

PF00293 (3/3) NUDIX domain

jaccard_groups_21

325.60 +- 323.07

0.03 +- 0.08

TIGR03696 (3/3) RHS repeat-associated core domain
TIGR01643 (2/3) YD repeat (two copies)
TIGR01443 (2/3) intein C-terminal splicing region
PF13385 (2/3) Concanavalin A-like lectin/glucanases superfamily
PF07591 (2/3) Pretoxin HINT domain
PF05593 (2/3) RHS Repeat

jaccard_groups_23

135.79 +- 170.09

0.07 +- 0.12

PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain
PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (3/4) Major Facilitator Superfamily

jaccard_groups_4226

444.94 +- 356.18

0.03 +- 0.04

jaccard_groups_3896

821.14 +- 717.35

0.05 +- 0.15

TIGR01928 (4/4) o-succinylbenzoate synthase
TIGR01727 (4/4) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (4/4) LD-carboxypeptidase C-terminal domain
PF13378 (4/4) Enolase C-terminal domain-like
PF08352 (4/4) Oligopeptide/dipeptide transporter, C-terminal region
PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02016 (4/4) LD-carboxypeptidase N-terminal domain
PF01546 (4/4) Peptidase family M20/M25/M40
PF01380 (4/4) SIS domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00496 (4/4) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (4/4) ABC transporter
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF12831 (3/4) FAD dependent oxidoreductase
PF07883 (3/4) Cupin domain
PF07690 (3/4) Major Facilitator Superfamily
PF02515 (3/4) CoA-transferase family III
PF01381 (3/4) Helix-turn-helix
PF00701 (3/4) Dihydrodipicolinate synthetase family
PF00378 (3/4) Enoyl-CoA hydratase/isomerase
PF00171 (3/4) Aldehyde dehydrogenase family

jaccard_groups_29

162.56 +- 163.90

0.03 +- 0.04

PF00583 (7/7) Acetyltransferase (GNAT) family

jaccard_groups_349

258.00 +- 0.00

0.01 +- 0.01

PF03067 (2/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01522 (1/2) Polysaccharide deacetylase
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01145 (1/2) SPFH domain / Band 7 family
PF00877 (1/2) NlpC/P60 family

jaccard_groups_178

362.00 +- 154.00

0.01 +- 0.01

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

jaccard_groups_3030

124.21 +- 42.94

0.06 +- 0.06

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF01756 (2/2) Acyl-CoA oxidase
PF00550 (2/2) Phosphopantetheine attachment site
PF00294 (2/2) pfkB family carbohydrate kinase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF12840 (1/2) Helix-turn-helix domain
PF10400 (1/2) Virulence activator alpha C-term
PF03551 (1/2) Transcriptional regulator PadR-like family
PF01497 (1/2) Periplasmic binding protein
PF00005 (1/2) ABC transporter

jaccard_groups_1341

234.18 +- 83.20

0.08 +- 0.09

TIGR01234 (3/3) ribulokinase
PF14200 (3/3) Ricin-type beta-trefoil lectin domain-like
PF11762 (3/3) L-arabinose isomerase C-terminal domain
PF06964 (3/3) Alpha-L-arabinofuranosidase C-terminal domain
PF02782 (3/3) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (3/3) L-arabinose isomerase
PF01547 (3/3) Bacterial extracellular solute-binding protein
PF00596 (3/3) Class II Aldolase and Adducin N-terminal domain
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00370 (3/3) FGGY family of carbohydrate kinases, N-terminal domain
PF18029 (2/3) Glyoxalase-like domain

jaccard_groups_1268

97.17 +- 73.63

0.05 +- 0.04

PF00106 (3/3) short chain dehydrogenase
PF12833 (2/3) Helix-turn-helix domain
PF12625 (2/3) Arabinose-binding domain of AraC transcription regulator, N-term
PF02416 (2/3) mttA/Hcf106 family
PF00743 (2/3) Flavin-binding monooxygenase-like
PF00171 (2/3) Aldehyde dehydrogenase family

jaccard_groups_5131

516.00 +- 0.00

0.01 +- 0.00

jaccard_groups_6119

292.50 +- 0.00

0.01 +- 0.00

PF01323 (2/2) DSBA-like thioredoxin domain
PF00378 (2/2) Enoyl-CoA hydratase/isomerase
PF00082 (2/2) Subtilase family

jaccard_groups_3009

387.00 +- 271.72

0.04 +- 0.03

TIGR04050 (2/2) AIR synthase-related protein, MSMEG_0567 C-terminal family
TIGR04047 (2/2) glycosyltransferase, MSMEG_0565 family
TIGR04046 (2/2) flavin-dependent oxidoreductase, MSMEG_0569 family
TIGR04045 (2/2) putative N-acetyltransferase, MSMEG_0567 N-terminal domain family
TIGR04044 (2/2) MSMEG_0572 family protein
TIGR04043 (2/2) radical SAM protein, MSMEG_0568 family
TIGR04042 (2/2) MSMEG_0570 family protein
PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase
PF13439 (2/2) Glycosyltransferase Family 4
PF04909 (2/2) Amidohydrolase
PF04055 (2/2) Radical SAM superfamily
PF02769 (2/2) AIR synthase related protein, C-terminal domain
PF02635 (2/2) DsrE/DsrF-like family
PF00795 (2/2) Carbon-nitrogen hydrolase
PF00586 (2/2) AIR synthase related protein, N-terminal domain
PF00583 (2/2) Acetyltransferase (GNAT) family
PF00534 (2/2) Glycosyl transferases group 1
TIGR01910 (1/2) peptidase, ArgE/DapE family
PF18029 (1/2) Glyoxalase-like domain
PF16990 (1/2) Carbohydrate binding module (family 35)
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01546 (1/2) Peptidase family M20/M25/M40
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family

jaccard_groups_3413

260.72 +- 115.49

0.01 +- 0.01

TIGR02532 (7/7) prepilin-type N-terminal cleavage/methylation domain
PF07963 (7/7) Prokaryotic N-terminal methylation motif
PF06750 (7/7) Bacterial Peptidase A24 N-terminal domain
PF03551 (7/7) Transcriptional regulator PadR-like family
PF01478 (7/7) Type IV leader peptidase family

jaccard_groups_4315

1556.00 +- 516.03

0.01 +- 0.00

jaccard_groups_3003

1355.01 +- 1011.49

0.03 +- 0.08

PF13622 (7/7) Thioesterase-like superfamily
PF00550 (7/7) Phosphopantetheine attachment site
PF00501 (7/7) AMP-binding enzyme
PF00487 (7/7) Fatty acid desaturase
PF00301 (7/7) Rubredoxin
PF00067 (7/7) Cytochrome P450
PF07690 (6/7) Major Facilitator Superfamily
PF12146 (5/7) Serine aminopeptidase, S33
PF12679 (4/7) ABC-2 family transporter protein
PF00005 (4/7) ABC transporter

jaccard_groups_6202

571.90 +- 331.10

0.02 +- 0.03

jaccard_groups_537

40.72 +- 12.05

0.06 +- 0.14

PF13641 (2/2) Glycosyltransferase like family 2
PF01757 (2/2) Acyltransferase family
PF01522 (2/2) Polysaccharide deacetylase
PF18616 (1/2) CDI immunity proteins
PF03466 (1/2) LysR substrate binding domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_3091

1255.97 +- 999.97

0.03 +- 0.06

jaccard_groups_533

69.67 +- 7.31

0.03 +- 0.03

PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00067 (2/3) Cytochrome P450

jaccard_groups_4218

516.00 +- 258.00

0.02 +- 0.03

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

jaccard_groups_538

717.07 +- 434.19

0.03 +- 0.03

PF13416 (8/8) Bacterial extracellular solute-binding protein
PF08402 (8/8) TOBE domain
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
PF00962 (4/8) Adenosine/AMP deaminase

jaccard_groups_17

103.93 +- 69.03

0.04 +- 0.05

PF07702 (9/9) UTRA domain
PF00392 (9/9) Bacterial regulatory proteins, gntR family

jaccard_groups_459

261.23 +- 64.11

0.01 +- 0.01

jaccard_groups_755

275.25 +- 17.25

0.01 +- 0.00

TIGR00231 (2/2) small GTP-binding protein domain
PF14492 (2/2) Elongation Factor G, domain II
PF03764 (2/2) Elongation factor G, domain IV
PF00679 (2/2) Elongation factor G C-terminus
PF00009 (2/2) Elongation factor Tu GTP binding domain
PF16864 (1/2) Dimerisation domain
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF01494 (1/2) FAD binding domain
PF00891 (1/2) O-methyltransferase domain
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)

jaccard_groups_1869

365.99 +- 130.08

0.06 +- 0.03

PF13561 (14/14) Enoyl-(Acyl carrier protein) reductase
PF08545 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (14/14) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (14/14) Beta-ketoacyl synthase, C-terminal domain
PF00378 (14/14) Enoyl-CoA hydratase/isomerase
PF00109 (14/14) Beta-ketoacyl synthase, N-terminal domain
PF00106 (14/14) short chain dehydrogenase
TIGR00976 (13/14) hydrolase CocE/NonD family protein
PF13193 (13/14) AMP-binding enzyme C-terminal domain
PF08530 (13/14) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (13/14) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (13/14) Coenzyme A transferase
PF00501 (13/14) AMP-binding enzyme
PF00196 (13/14) Bacterial regulatory proteins, luxR family
PF00005 (13/14) ABC transporter
PF04909 (12/14) Amidohydrolase
PF12679 (10/14) ABC-2 family transporter protein
PF12697 (9/14) Alpha/beta hydrolase family

jaccard_groups_128

110.12 +- 103.02

0.04 +- 0.05

PF01872 (10/10) RibD C-terminal domain

jaccard_groups_127

154.80 +- 0.00

0.02 +- 0.01

jaccard_groups_2734

595.57 +- 149.62

0.01 +- 0.00

jaccard_groups_2138

57.64 +- 2.36

0.07 +- 0.09

PF04203 (2/2) Sortase domain
PF04149 (2/2) Domain of unknown function (DUF397)
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family

jaccard_groups_122

269.82 +- 196.36

0.04 +- 0.06

PF11706 (3/3) CGNR zinc finger
PF07336 (3/3) Putative stress-induced transcription regulator

jaccard_groups_4359

73.12 +- 24.38

0.03 +- 0.02

PF06912 (2/2) Protein of unknown function (DUF1275)
PF02308 (2/2) MgtC family
PF01566 (2/2) Natural resistance-associated macrophage protein

jaccard_groups_1295

60.20 +- 25.80

0.03 +- 0.04

PF04231 (2/2) Endonuclease I
PF11239 (1/2) Protein of unknown function (DUF3040)
PF10706 (1/2) Aminoglycoside-2''-adenylyltransferase

jaccard_groups_2927

622.29 +- 125.90

0.01 +- 0.02

TIGR01250 (3/3) proline-specific peptidase
PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02310 (3/3) B12 binding domain
PF00561 (3/3) alpha/beta hydrolase fold
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00067 (3/3) Cytochrome P450

jaccard_groups_1740

228.06 +- 94.91

0.06 +- 0.09

PF18565 (4/4) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (4/4) Domain of unknown function (DUF4982)
PF14310 (4/4) Fibronectin type III-like domain
PF02837 (4/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (4/4) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (4/4) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (4/4) Glycosyl hydrolase family 3 N terminal domain
PF00703 (4/4) Glycosyl hydrolases family 2
PF17390 (3/4) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (3/4) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF13561 (3/4) Enoyl-(Acyl carrier protein) reductase
PF08531 (3/4) Alpha-L-rhamnosidase N-terminal domain
PF07859 (3/4) alpha/beta hydrolase fold
PF05592 (3/4) Bacterial alpha-L-rhamnosidase concanavalin-like domain

jaccard_groups_1465

83.73 +- 28.80

0.05 +- 0.05

PF07690 (3/3) Major Facilitator Superfamily
PF05893 (3/3) Acyl-CoA reductase (LuxC)
PF04443 (3/3) Acyl-protein synthetase, LuxE
PF00583 (3/3) Acetyltransferase (GNAT) family
PF00501 (3/3) AMP-binding enzyme

jaccard_groups_984

274.59 +- 266.03

0.03 +- 0.05

PF07690 (15/15) Major Facilitator Superfamily
PF04055 (14/15) Radical SAM superfamily
PF13649 (11/15) Methyltransferase domain

jaccard_groups_3631

516.88 +- 343.12

0.04 +- 0.11

jaccard_groups_150

137.60 +- 34.40

0.02 +- 0.01

PF04672 (2/2) S-adenosyl methyltransferase
TIGR03296 (1/2) M6 family metalloprotease domain
PF13649 (1/2) Methyltransferase domain

jaccard_groups_5491

961.71 +- 70.29

0.01 +- 0.00

jaccard_groups_2218

454.73 +- 318.28

0.05 +- 0.08

PF13411 (6/6) MerR HTH family regulatory protein
PF07739 (6/6) TipAS antibiotic-recognition domain
PF03033 (6/6) Glycosyltransferase family 28 N-terminal domain
PF01551 (6/6) Peptidase family M23
PF00392 (6/6) Bacterial regulatory proteins, gntR family
PF00005 (6/6) ABC transporter
PF12679 (5/6) ABC-2 family transporter protein

jaccard_groups_2357

138.29 +- 11.26

0.06 +- 0.16

TIGR02412 (2/2) aminopeptidase N
TIGR01686 (2/2) FkbH domain
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF18130 (2/2) ATP-grasp N-terminal domain
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (2/2) ERAP1-like C-terminal domain
PF09334 (2/2) tRNA synthetases class I (M)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF02274 (2/2) Amidinotransferase
PF01433 (2/2) Peptidase family M1 domain
PF01266 (2/2) FAD dependent oxidoreductase
PF00999 (2/2) Sodium/hydrogen exchanger family
PF00550 (2/2) Phosphopantetheine attachment site
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF17900 (1/2) Peptidase M1 N-terminal domain
PF03466 (1/2) LysR substrate binding domain
PF02195 (1/2) ParB-like nuclease domain
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_5496

155.40 +- 85.40

0.04 +- 0.04

jaccard_groups_2608

1607.67 +- 212.33

0.01 +- 0.00

jaccard_groups_393

101.79 +- 64.37

0.03 +- 0.02

PF12833 (20/20) Helix-turn-helix domain
PF02311 (20/20) AraC-like ligand binding domain
PF00150 (19/20) Cellulase (glycosyl hydrolase family 5)

jaccard_groups_2851

45.39 +- 2.39

0.04 +- 0.04

jaccard_groups_2323

87.16 +- 61.05

0.04 +- 0.08

PF03965 (3/3) Penicillinase repressor
PF01435 (3/3) Peptidase family M48
PF00403 (3/3) Heavy-metal-associated domain
PF00877 (2/3) NlpC/P60 family

jaccard_groups_2321

388.80 +- 1.47

0.01 +- 0.00

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)

jaccard_groups_1046

301.58 +- 214.44

0.07 +- 0.15

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF05147 (4/4) Lanthionine synthetase C-like protein
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF00296 (4/4) Luciferase-like monooxygenase
PF00005 (4/4) ABC transporter
TIGR03558 (2/4) luciferase family oxidoreductase, group 1
PF13649 (2/4) Methyltransferase domain
PF01292 (2/4) Prokaryotic cytochrome b561
PF00196 (2/4) Bacterial regulatory proteins, luxR family
PF00188 (2/4) Cysteine-rich secretory protein family
PF00174 (2/4) Oxidoreductase molybdopterin binding domain
PF00072 (2/4) Response regulator receiver domain

jaccard_groups_1045

608.93 +- 519.61

0.03 +- 0.05

TIGR03945 (5/5) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR01733 (5/5) amino acid adenylation domain
PF13193 (5/5) AMP-binding enzyme C-terminal domain
PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family
PF00550 (5/5) Phosphopantetheine attachment site
PF00501 (5/5) AMP-binding enzyme
PF00291 (5/5) Pyridoxal-phosphate dependent enzyme
TIGR03944 (4/5) 2,3-diaminopropionate biosynthesis protein SbnB
PF00975 (4/5) Thioesterase domain
PF02668 (3/5) Taurine catabolism dioxygenase TauD, TfdA family
PF00668 (3/5) Condensation domain

jaccard_groups_628

28.77 +- 5.25

0.07 +- 0.09

PF13244 (10/10) Domain of unknown function (DUF4040)
PF04066 (10/10) Multiple resistance and pH regulation protein F (MrpF / PhaF)
PF04039 (10/10) Domain related to MnhB subunit of Na+/H+ antiporter
PF00420 (10/10) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (10/10) Proton-conducting membrane transporter
PF12840 (9/10) Helix-turn-helix domain

jaccard_groups_2516

118.50 +- 53.50

0.05 +- 0.07

jaccard_groups_302

291.55 +- 224.45

0.03 +- 0.06

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

jaccard_groups_300

2363.38 +- 2722.61

0.03 +- 0.08

TIGR03882 (59/59) bacteriocin biosynthesis cyclodehydratase domain
PF02624 (59/59) YcaO cyclodehydratase, ATP-ad Mg2+-binding
TIGR03604 (58/59) thiazole/oxazole-forming peptide maturase, SagD family component
PF00881 (58/59) Nitroreductase family
PF14028 (57/59) Lantibiotic biosynthesis dehydratase C-term
PF00005 (41/59) ABC transporter
PF04738 (40/59) Lantibiotic dehydratase, N terminus
PF01061 (33/59) ABC-2 type transporter
TIGR03605 (30/59) SagB-type dehydrogenase domain

jaccard_groups_78

154.21 +- 58.34

0.07 +- 0.05

PF13416 (3/3) Bacterial extracellular solute-binding protein
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF17831 (2/3) Pyruvate dehydrogenase E1 component middle domain
PF00456 (2/3) Transketolase, thiamine diphosphate binding domain
PF00266 (2/3) Aminotransferase class-V

jaccard_groups_5672

246.49 +- 143.51

0.04 +- 0.15

jaccard_groups_73

411.67 +- 186.38

0.03 +- 0.03

PF01061 (3/3) ABC-2 type transporter
PF00005 (3/3) ABC transporter
PF00082 (2/3) Subtilase family

jaccard_groups_4270

122.11 +- 15.00

0.08 +- 0.21

jaccard_groups_76

709.50 +- 322.50

0.01 +- 0.00

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
TIGR03296 (1/2) M6 family metalloprotease domain
PF07158 (1/2) Dicarboxylate carrier protein MatC N-terminus
PF01471 (1/2) Putative peptidoglycan binding domain
PF00939 (1/2) Sodium:sulfate symporter transmembrane region
PF00293 (1/2) NUDIX domain

jaccard_groups_4274

118.18 +- 51.61

0.04 +- 0.03

PF13377 (4/4) Periplasmic binding protein-like domain
PF08124 (4/4) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF02884 (4/4) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02278 (4/4) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF17291 (3/4) N-terminal domain of M60-like peptidases
PF13402 (3/4) Peptidase M60, enhancin and enhancin-like
PF10022 (3/4) Uncharacterized protein conserved in bacteria (DUF2264)
PF02826 (3/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

jaccard_groups_4730

915.56 +- 502.62

0.01 +- 0.01

jaccard_groups_4301

275.37 +- 49.63

0.02 +- 0.02

jaccard_groups_5373

133.61 +- 63.96

0.09 +- 0.20

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF16864 (2/2) Dimerisation domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF04389 (2/2) Peptidase family M28
PF03621 (2/2) MbtH-like protein
PF00891 (2/2) O-methyltransferase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF13847 (1/2) Methyltransferase domain
PF13459 (1/2) 4Fe-4S single cluster domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00067 (1/2) Cytochrome P450

jaccard_groups_4878

1332.86 +- 227.14

0.01 +- 0.01

TIGR01879 (2/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (2/2) dihydroorotate dehydrogenase family protein
TIGR00857 (2/2) dihydroorotase, multifunctional complex type
PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF09084 (2/2) NMT1/THI5 like
PF01979 (2/2) Amidohydrolase family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01180 (2/2) Dihydroorotate dehydrogenase
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00005 (2/2) ABC transporter
PF00589 (1/2) Phage integrase family

jaccard_groups_1228

327.66 +- 69.66

0.02 +- 0.02

PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
PF13407 (1/2) Periplasmic binding protein domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF00005 (1/2) ABC transporter

jaccard_groups_5078

303.16 +- 34.84

0.06 +- 0.10

jaccard_groups_3743

233.66 +- 123.26

0.02 +- 0.03

jaccard_groups_1223

173.25 +- 198.69

0.05 +- 0.09

PF07992 (8/8) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (8/8) BFD-like [2Fe-2S] binding domain
PF02782 (8/8) FGGY family of carbohydrate kinases, C-terminal domain
PF01266 (8/8) FAD dependent oxidoreductase
PF00370 (8/8) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (5/8) NUDIX domain

jaccard_groups_5175

358.87 +- 76.47

0.03 +- 0.03

jaccard_groups_4575

396.47 +- 171.88

0.01 +- 0.02

jaccard_groups_5088

376.25 +- 0.00

0.03 +- 0.03

jaccard_groups_3228

169.73 +- 174.91

0.05 +- 0.09

jaccard_groups_278

125.60 +- 103.73

0.06 +- 0.13

PF03965 (2/2) Penicillinase repressor
PF01435 (2/2) Peptidase family M48
PF08241 (1/2) Methyltransferase domain
PF00149 (1/2) Calcineurin-like phosphoesterase

jaccard_groups_1313

119.65 +- 40.51

0.08 +- 0.07

PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF04199 (2/2) Putative cyclase
PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (2/2) FAD binding domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
TIGR01780 (1/2) succinate-semialdehyde dehydrogenase
PF12802 (1/2) MarR family
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF04909 (1/2) Amidohydrolase
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01614 (1/2) Bacterial transcriptional regulator
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00171 (1/2) Aldehyde dehydrogenase family

jaccard_groups_418

88.83 +- 41.22

0.03 +- 0.04

PF08031 (3/3) Berberine and berberine like
PF01565 (3/3) FAD binding domain
PF08386 (2/3) TAP-like protein
PF00561 (2/3) alpha/beta hydrolase fold

jaccard_groups_413

197.80 +- 88.43

0.02 +- 0.01

PF02838 (4/4) Glycosyl hydrolase family 20, domain 2
PF00728 (4/4) Glycosyl hydrolase family 20, catalytic domain
PF00754 (3/4) F5/8 type C domain
PF01120 (2/4) Alpha-L-fucosidase

jaccard_groups_2173

216.00 +- 44.00

0.01 +- 0.00

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain

jaccard_groups_6027

100.28 +- 9.84

0.06 +- 0.06

jaccard_groups_2106

429.44 +- 25.56

0.04 +- 0.04

TIGR01733 (2/2) amino acid adenylation domain
PF16653 (2/2) Saccharopine dehydrogenase C-terminal domain
PF14518 (2/2) Iron-containing redox enzyme
PF13714 (2/2) Phosphoenolpyruvate phosphomutase
PF13535 (2/2) ATP-grasp domain
PF13434 (2/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (2/2) Acetyltransferase (GNAT) domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF09334 (2/2) tRNA synthetases class I (M)
PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (2/2) Cupin domain
PF07690 (2/2) Major Facilitator Superfamily
PF05222 (2/2) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (2/2) Saccharopine dehydrogenase NADP binding domain
PF03417 (2/2) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily
PF01266 (2/2) FAD dependent oxidoreductase
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (2/2) Cytochrome P450
PF18563 (1/2) TubC N-terminal docking domain

jaccard_groups_3592

383.81 +- 168.05

0.01 +- 0.03

jaccard_groups_2688

97.38 +- 49.07

0.05 +- 0.06

TIGR01180 (3/3) putative alpha-1,2-mannosidase
PF17678 (3/3) Glycosyl hydrolase family 92 N-terminal domain
PF07971 (3/3) Glycosyl hydrolase family 92
PF02518 (3/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (3/3) HAMP domain
PF00553 (3/3) Cellulose binding domain
PF00512 (3/3) His Kinase A (phospho-acceptor) domain
PF03067 (2/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading

jaccard_groups_663

58.05 +- 5.27

0.05 +- 0.03

PF02386 (3/3) Cation transport protein
PF02254 (3/3) TrkA-N domain
PF02080 (3/3) TrkA-C domain
PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF00501 (2/3) AMP-binding enzyme

jaccard_groups_2081

128.66 +- 34.98

0.02 +- 0.03

PF07690 (4/4) Major Facilitator Superfamily
PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme
PF13302 (2/4) Acetyltransferase (GNAT) domain
PF01255 (2/4) Putative undecaprenyl diphosphate synthase

jaccard_groups_3774

303.45 +- 53.54

0.02 +- 0.01

jaccard_groups_110

228.87 +- 47.17

0.01 +- 0.01

PF13545 (10/10) Crp-like helix-turn-helix domain
PF00027 (10/10) Cyclic nucleotide-binding domain
PF07228 (9/10) Stage II sporulation protein E (SpoIIE)

jaccard_groups_111

356.38 +- 193.33

0.02 +- 0.04

PF16197 (3/3) Ketoacyl-synthetase C-terminal extension
PF14765 (3/3) Polyketide synthase dehydratase
PF08659 (3/3) KR domain
PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain
PF00698 (3/3) Acyl transferase domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain
PF01648 (2/3) 4'-phosphopantetheinyl transferase superfamily
PF00561 (2/3) alpha/beta hydrolase fold
PF00201 (2/3) UDP-glucoronosyl and UDP-glucosyl transferase

jaccard_groups_2312

383.41 +- 360.05

0.06 +- 0.07

TIGR00976 (8/8) hydrolase CocE/NonD family protein
PF08530 (8/8) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (8/8) X-Pro dipeptidyl-peptidase (S15 family)
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00005 (8/8) ABC transporter
TIGR01726 (7/8) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF00583 (7/8) Acetyltransferase (GNAT) family
PF00497 (7/8) Bacterial extracellular solute-binding proteins, family 3
PF01244 (6/8) Membrane dipeptidase (Peptidase family M19)
PF00296 (4/8) Luciferase-like monooxygenase

jaccard_groups_119

480.00 +- 547.55

0.02 +- 0.03

TIGR03891 (31/31) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (31/31) Lantibiotic biosynthesis dehydratase C-term
PF05147 (31/31) Lanthionine synthetase C-like protein
PF04738 (30/31) Lantibiotic dehydratase, N terminus
PF00005 (17/31) ABC transporter

jaccard_groups_2955

2158.41 +- 761.00

0.01 +- 0.01

jaccard_groups_2817

415.68 +- 202.70

0.03 +- 0.02

TIGR04469 (2/2) CGA synthase-related protein
TIGR04468 (2/2) arginine 2,3-aminomutase
TIGR04467 (2/2) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (2/2) cytosylglucuronate decarboxylase
PF18603 (2/2) L-amino acid ligase C-terminal domain 2
PF08241 (2/2) Methyltransferase domain
PF05014 (2/2) Nucleoside 2-deoxyribosyltransferase
PF04055 (2/2) Radical SAM superfamily
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF07690 (1/2) Major Facilitator Superfamily
PF01433 (1/2) Peptidase family M1 domain
PF00296 (1/2) Luciferase-like monooxygenase

jaccard_groups_2774

885.57 +- 176.07

0.01 +- 0.01

jaccard_groups_1554

114.67 +- 64.87

0.06 +- 0.04

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain
PF00501 (3/3) AMP-binding enzyme
PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain
PF14864 (2/3) Alkyl sulfatase C-terminal
PF14863 (2/3) Alkyl sulfatase dimerisation
PF00753 (2/3) Metallo-beta-lactamase superfamily

jaccard_groups_1000

306.75 +- 209.25

0.02 +- 0.02

PF13466 (2/2) STAS domain
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF02607 (2/2) B12 binding domain
PF02310 (2/2) B12 binding domain
PF08031 (1/2) Berberine and berberine like
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF01565 (1/2) FAD binding domain
PF00239 (1/2) Resolvase, N terminal domain

jaccard_groups_5850

977.21 +- 452.79

0.01 +- 0.02

TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase
TIGR03969 (2/2) mycofactocin precursor
TIGR03967 (2/2) putative mycofactocin binding protein MftB
TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system
TIGR03965 (2/2) mycofactocin system glycosyltransferase
TIGR03964 (2/2) mycofactocin system creatininase family protein
TIGR03962 (2/2) mycofactocin radical SAM maturase
PF17676 (2/2) LD-carboxypeptidase C-terminal domain
PF16861 (2/2) Carbamoyltransferase C-terminus
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13489 (2/2) Methyltransferase domain
PF13186 (2/2) Iron-sulfur cluster-binding domain
PF08242 (2/2) Methyltransferase domain
PF04055 (2/2) Radical SAM superfamily
PF03129 (2/2) Anticodon binding domain
PF02633 (2/2) Creatinine amidohydrolase
PF02543 (2/2) Carbamoyltransferase N-terminus
PF02016 (2/2) LD-carboxypeptidase N-terminal domain
PF01980 (2/2) tRNA-methyltransferase O
PF01070 (2/2) FMN-dependent dehydrogenase
PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T)
PF00535 (2/2) Glycosyl transferase family 2
PF00152 (2/2) tRNA synthetases class II (D, K and N)
PF00067 (2/2) Cytochrome P450

jaccard_groups_4050

300.06 +- 213.54

0.04 +- 0.05

jaccard_groups_3817

1991.35 +- 896.21

0.02 +- 0.10

jaccard_groups_3702

392.52 +- 261.55

0.04 +- 0.08

TIGR02937 (4/4) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (4/4) heavy metal translocating P-type ATPase
TIGR00802 (4/4) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (4/4) GYF domain 2
PF13421 (4/4) SPFH domain-Band 7 family
PF08281 (4/4) Sigma-70, region 4
PF07690 (4/4) Major Facilitator Superfamily
PF04542 (4/4) Sigma-70 region 2
PF04314 (4/4) Copper chaperone PCu(A)C
PF03824 (4/4) High-affinity nickel-transport protein
PF00702 (4/4) haloacid dehalogenase-like hydrolase
PF00403 (4/4) Heavy-metal-associated domain
PF00122 (4/4) E1-E2 ATPase
PF13738 (3/4) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (3/4) FMN-dependent dehydrogenase
PF00067 (3/4) Cytochrome P450
PF05118 (2/4) Aspartyl/Asparaginyl beta-hydroxylase

jaccard_groups_3700

32.13 +- 5.78

0.06 +- 0.11

TIGR01509 (3/3) HAD hydrolase, family IA, variant 3
PF13419 (3/3) Haloacid dehalogenase-like hydrolase
PF08386 (3/3) TAP-like protein
PF04149 (3/3) Domain of unknown function (DUF397)
PF02388 (3/3) FemAB family
PF00561 (3/3) alpha/beta hydrolase fold

jaccard_groups_3813

277.22 +- 74.60

0.08 +- 0.08

jaccard_groups_2652

3474.49 +- 3174.88

0.04 +- 0.05

TIGR01928 (2/2) o-succinylbenzoate synthase
TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13556 (2/2) PucR C-terminal helix-turn-helix domain
PF13378 (2/2) Enolase C-terminal domain-like
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07676 (2/2) WD40-like Beta Propeller Repeat
PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01546 (2/2) Peptidase family M20/M25/M40
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (2/2) Prolyl oligopeptidase family
PF00144 (2/2) Beta-lactamase
PF00005 (2/2) ABC transporter
PF17853 (1/2) GGDEF-like domain
PF13354 (1/2) Beta-lactamase enzyme family
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10400 (1/2) Virulence activator alpha C-term
PF08667 (1/2) BetR domain
PF07969 (1/2) Amidohydrolase family
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF03551 (1/2) Transcriptional regulator PadR-like family
PF03061 (1/2) Thioesterase superfamily
PF02687 (1/2) FtsX-like permease family
PF01381 (1/2) Helix-turn-helix
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00501 (1/2) AMP-binding enzyme

jaccard_groups_3955

1463.93 +- 1117.75

0.02 +- 0.01

jaccard_groups_2498

554.81 +- 177.49

0.02 +- 0.02

jaccard_groups_2553

191.56 +- 72.66

0.07 +- 0.11

jaccard_groups_1197

91.00 +- 39.00

0.03 +- 0.02

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase

jaccard_groups_2227

192.59 +- 95.33

0.02 +- 0.05

PF11303 (3/3) Protein of unknown function (DUF3105)
PF09286 (3/3) Pro-kumamolisin, activation domain
PF03713 (3/3) Domain of unknown function (DUF305)
PF00082 (3/3) Subtilase family

jaccard_groups_4625

189.23 +- 42.98

0.02 +- 0.01

jaccard_groups_1074

32.50 +- 0.00

0.06 +- 0.05

TIGR03296 (2/2) M6 family metalloprotease domain
PF01070 (2/2) FMN-dependent dehydrogenase

jaccard_groups_182

651.51 +- 518.49

0.05 +- 0.06

PF14310 (2/2) Fibronectin type III-like domain
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13802 (1/2) Galactose mutarotase-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (1/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF03422 (1/2) Carbohydrate binding module (family 6)
PF01055 (1/2) Glycosyl hydrolases family 31
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family

jaccard_groups_231

111.41 +- 17.59

0.04 +- 0.06

TIGR01180 (2/2) putative alpha-1,2-mannosidase
PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain
PF12833 (2/2) Helix-turn-helix domain
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07971 (2/2) Glycosyl hydrolase family 92
PF01965 (2/2) DJ-1/PfpI family
PF00754 (2/2) F5/8 type C domain
PF00107 (2/2) Zinc-binding dehydrogenase
PF00857 (1/2) Isochorismatase family

jaccard_groups_230

182.88 +- 297.22

0.04 +- 0.03

PF13471 (81/81) Transglutaminase-like superfamily
PF00733 (80/81) Asparagine synthase
PF05402 (69/81) Coenzyme PQQ synthesis protein D (PqqD)

jaccard_groups_2429

462.83 +- 311.17

0.02 +- 0.04

jaccard_groups_87

52.38 +- 14.29

0.07 +- 0.08

PF03450 (14/14) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (14/14) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (14/14) [2Fe-2S] binding domain
PF01315 (14/14) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (14/14) FAD binding domain in molybdopterin dehydrogenase

jaccard_groups_3255

414.64 +- 27.64

0.01 +- 0.00

PF12697 (2/2) Alpha/beta hydrolase family
PF07690 (2/2) Major Facilitator Superfamily
PF00884 (2/2) Sulfatase

jaccard_groups_36

97.43 +- 4.08

0.02 +- 0.02

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)

jaccard_groups_37

81.97 +- 63.87

0.04 +- 0.05

PF00106 (3/3) short chain dehydrogenase

jaccard_groups_34

791.63 +- 421.13

0.03 +- 0.11

TIGR01727 (9/9) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (9/9) Oligopeptide/dipeptide transporter, C-terminal region
PF00528 (9/9) Binding-protein-dependent transport system inner membrane component
PF00496 (9/9) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (9/9) ABC transporter

jaccard_groups_681

119.17 +- 54.17

0.03 +- 0.02

PF00754 (2/2) F5/8 type C domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF14099 (1/2) Polysaccharide lyase
PF04616 (1/2) Glycosyl hydrolases family 43
PF01120 (1/2) Alpha-L-fucosidase
PF00082 (1/2) Subtilase family

jaccard_groups_30

545.83 +- 791.07

0.03 +- 0.09

TIGR01733 (15/15) amino acid adenylation domain
PF13193 (15/15) AMP-binding enzyme C-terminal domain
PF00668 (15/15) Condensation domain
PF00550 (15/15) Phosphopantetheine attachment site
PF00501 (15/15) AMP-binding enzyme
PF00975 (12/15) Thioesterase domain

jaccard_groups_31

170.84 +- 87.16

0.05 +- 0.09

PF00067 (2/2) Cytochrome P450
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01427 (1/2) D-ala-D-ala dipeptidase

jaccard_groups_39

108.86 +- 77.01

0.03 +- 0.04

PF00561 (24/24) alpha/beta hydrolase fold
PF08386 (16/24) TAP-like protein

jaccard_groups_849

81.64 +- 74.60

0.05 +- 0.05

PF01874 (8/8) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (8/8) Dioxygenase

jaccard_groups_334

104.13 +- 69.20

0.08 +- 0.16

jaccard_groups_333

132.81 +- 14.62

0.03 +- 0.04

PF01738 (2/2) Dienelactone hydrolase family
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00156 (1/2) Phosphoribosyl transferase domain
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter

jaccard_groups_1216

123.93 +- 11.86

0.04 +- 0.05

PF04444 (2/2) Catechol dioxygenase N terminus
PF00775 (2/2) Dioxygenase
PF00465 (2/2) Iron-containing alcohol dehydrogenase
PF14525 (1/2) AraC-binding-like domain
PF12833 (1/2) Helix-turn-helix domain
PF07730 (1/2) Histidine kinase
PF03466 (1/2) LysR substrate binding domain
PF01494 (1/2) FAD binding domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00072 (1/2) Response regulator receiver domain

jaccard_groups_4801

122.27 +- 27.73

0.02 +- 0.01

jaccard_groups_6262

523.42 +- 54.35

0.05 +- 0.08

TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein
TIGR00594 (2/2) DNA polymerase III, alpha subunit
PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain
PF14579 (2/2) Helix-hairpin-helix motif
PF13575 (2/2) Domain of unknown function (DUF4135)
PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain
PF05147 (2/2) Lanthionine synthetase C-like protein
PF03412 (2/2) Peptidase C39 family
PF02811 (2/2) PHP domain
PF01336 (2/2) OB-fold nucleic acid binding domain
PF00664 (2/2) ABC transporter transmembrane region
PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
PF00107 (2/2) Zinc-binding dehydrogenase
PF00005 (2/2) ABC transporter
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF07366 (1/2) SnoaL-like polyketide cyclase

jaccard_groups_3405

505.11 +- 323.47

0.03 +- 0.09

TIGR00556 (3/3) phosphopantetheine--protein transferase domain
TIGR00027 (3/3) methyltransferase, TIGR00027 family
PF12706 (3/3) Beta-lactamase superfamily domain
PF11583 (3/3) P-aminobenzoate N-oxygenase AurF
PF07690 (3/3) Major Facilitator Superfamily
PF06628 (3/3) Catalase-related immune-responsive
PF04072 (3/3) Leucine carboxyl methyltransferase
PF01648 (3/3) 4'-phosphopantetheinyl transferase superfamily
PF01575 (3/3) MaoC like domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00199 (3/3) Catalase
PF09947 (2/3) Uncharacterized protein conserved in archaea (DUF2180)

jaccard_groups_337

205.76 +- 106.24

0.06 +- 0.13

PF05199 (2/2) GMC oxidoreductase
PF00732 (2/2) GMC oxidoreductase
TIGR02462 (1/2) pyranose oxidase
PF12902 (1/2) Ferritin-like
PF07690 (1/2) Major Facilitator Superfamily
PF03928 (1/2) Haem-degrading
PF01551 (1/2) Peptidase family M23
PF01471 (1/2) Putative peptidoglycan binding domain

jaccard_groups_6471

545.32 +- 29.32

0.01 +- 0.00

PF04199 (2/2) Putative cyclase
PF02728 (2/2) Copper amine oxidase, N3 domain
PF01179 (2/2) Copper amine oxidase, enzyme domain
PF01019 (2/2) Gamma-glutamyltranspeptidase
PF00355 (2/2) Rieske [2Fe-2S] domain
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00120 (2/2) Glutamine synthetase, catalytic domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF00753 (1/2) Metallo-beta-lactamase superfamily

jaccard_groups_529

183.10 +- 82.91

0.01 +- 0.01

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase

jaccard_groups_247

426.40 +- 283.00

0.02 +- 0.05

TIGR03897 (8/8) type 2 lantibiotic biosynthesis protein LanM
PF13575 (8/8) Domain of unknown function (DUF4135)
PF05147 (8/8) Lanthionine synthetase C-like protein
PF03704 (6/8) Bacterial transcriptional activator domain
PF00486 (6/8) Transcriptional regulatory protein, C terminal
PF13191 (5/8) AAA ATPase domain
PF00931 (5/8) NB-ARC domain
PF00196 (5/8) Bacterial regulatory proteins, luxR family
PF13185 (4/8) GAF domain
PF08448 (4/8) PAS fold
PF07228 (4/8) Stage II sporulation protein E (SpoIIE)

jaccard_groups_428

50.92 +- 20.56

0.06 +- 0.05

PF00174 (4/4) Oxidoreductase molybdopterin binding domain
PF01292 (3/4) Prokaryotic cytochrome b561
PF07519 (2/4) Tannase and feruloyl esterase

jaccard_groups_740

91.14 +- 8.59

0.03 +- 0.04

PF13480 (3/3) Acetyltransferase (GNAT) domain
PF02156 (3/3) Glycosyl hydrolase family 26
PF01522 (3/3) Polysaccharide deacetylase
PF00535 (3/3) Glycosyl transferase family 2

jaccard_groups_2136

953.88 +- 214.88

0.01 +- 0.01

TIGR04085 (6/6) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (6/6) Iron-sulfur cluster-binding domain
PF05402 (6/6) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (6/6) Radical SAM superfamily
PF00005 (6/6) ABC transporter
PF01061 (4/6) ABC-2 type transporter
PF00717 (4/6) Peptidase S24-like

jaccard_groups_1286

142.22 +- 29.78

0.06 +- 0.03

jaccard_groups_6065

1029.17 +- 97.50

0.01 +- 0.01

jaccard_groups_1283

491.11 +- 40.86

0.01 +- 0.00

PF07690 (3/3) Major Facilitator Superfamily
PF18029 (2/3) Glyoxalase-like domain
PF00903 (2/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

jaccard_groups_2911

759.98 +- 690.09

0.06 +- 0.20

jaccard_groups_1296

478.51 +- 301.49

0.03 +- 0.05

PF14765 (2/2) Polyketide synthase dehydratase
PF13489 (2/2) Methyltransferase domain
PF08659 (2/2) KR domain
PF03060 (2/2) Nitronate monooxygenase
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (2/2) Acyl transferase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR01426 (1/2) glycosyltransferase, MGT family
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF12146 (1/2) Serine aminopeptidase, S33
PF07859 (1/2) alpha/beta hydrolase fold
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family

jaccard_groups_2148

178.59 +- 147.68

0.04 +- 0.04

PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase
PF00067 (3/3) Cytochrome P450
PF03745 (2/3) Domain of unknown function (DUF309)

jaccard_groups_6081

895.44 +- 308.77

0.02 +- 0.03

jaccard_groups_3628

2401.56 +- 1135.16

0.02 +- 0.01

jaccard_groups_142

126.17 +- 68.83

0.03 +- 0.04

PF04978 (2/2) Protein of unknown function (DUF664)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF03795 (1/2) YCII-related domain
PF01636 (1/2) Phosphotransferase enzyme family

jaccard_groups_145

388.16 +- 408.77

0.05 +- 0.11

PF13407 (6/6) Periplasmic binding protein domain
PF02653 (6/6) Branched-chain amino acid transport system / permease component
PF00005 (6/6) ABC transporter
PF13377 (5/6) Periplasmic binding protein-like domain
PF00356 (5/6) Bacterial regulatory proteins, lacI family
PF00294 (5/6) pfkB family carbohydrate kinase
PF05025 (4/6) RbsD / FucU transport protein family

jaccard_groups_6059

1548.00 +- 0.00

0.01 +- 0.00

jaccard_groups_2269

155.79 +- 11.35

0.03 +- 0.07

TIGR01733 (2/2) amino acid adenylation domain
PF07690 (2/2) Major Facilitator Superfamily
PF01361 (2/2) Tautomerase enzyme
PF00975 (2/2) Thioesterase domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF17645 (1/2) Arylmalonate decarboxylase
PF14681 (1/2) Uracil phosphoribosyltransferase
PF14027 (1/2) Questin oxidase-like
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF11695 (1/2) Domain of unknown function (DUF3291)
PF08962 (1/2) Domain of unknown function (DUF1876)
PF08386 (1/2) TAP-like protein
PF04227 (1/2) Indigoidine synthase A like protein
PF00561 (1/2) alpha/beta hydrolase fold
PF00144 (1/2) Beta-lactamase

jaccard_groups_2348

481.99 +- 169.64

0.02 +- 0.01

TIGR01850 (10/10) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (10/10) alpha-L-glutamate ligase, RimK family
PF13193 (10/10) AMP-binding enzyme C-terminal domain
PF08443 (10/10) RimK-like ATP-grasp domain
PF02780 (10/10) Transketolase, C-terminal domain
PF02779 (10/10) Transketolase, pyrimidine binding domain
PF02771 (10/10) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (10/10) Acyl-CoA dehydrogenase, middle domain
PF01118 (10/10) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (10/10) AMP-binding enzyme
PF00456 (10/10) Transketolase, thiamine diphosphate binding domain
PF00441 (10/10) Acyl-CoA dehydrogenase, C-terminal domain
PF03466 (9/10) LysR substrate binding domain
PF00126 (9/10) Bacterial regulatory helix-turn-helix protein, lysR family

jaccard_groups_2263

133.48 +- 31.64

0.04 +- 0.04

jaccard_groups_4149

75.88 +- 0.00

0.07 +- 0.07

jaccard_groups_1913

91.36 +- 15.97

0.06 +- 0.11

PF12450 (3/3) von Willebrand factor
PF12034 (3/3) Domain of unknown function (DUF3520)
PF10502 (3/3) Signal peptidase, peptidase S26
PF07291 (3/3) Methylamine utilisation protein MauE
PF00717 (3/3) Peptidase S24-like
PF00501 (3/3) AMP-binding enzyme
PF00092 (3/3) von Willebrand factor type A domain
PF00005 (3/3) ABC transporter

jaccard_groups_1527

152.71 +- 40.50

0.02 +- 0.01

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain

jaccard_groups_4412

1472.40 +- 491.27

0.01 +- 0.01

TIGR01727 (3/3) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase
PF13378 (3/3) Enolase C-terminal domain-like
PF13183 (3/3) 4Fe-4S dicluster domain
PF08352 (3/3) Oligopeptide/dipeptide transporter, C-terminal region
PF07729 (3/3) FCD domain
PF03737 (3/3) Aldolase/RraA
PF02913 (3/3) FAD linked oxidases, C-terminal domain
PF02754 (3/3) Cysteine-rich domain
PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01565 (3/3) FAD binding domain
PF01229 (3/3) Glycosyl hydrolases family 39
PF00528 (3/3) Binding-protein-dependent transport system inner membrane component
PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00005 (3/3) ABC transporter

jaccard_groups_4066

107.65 +- 48.04

0.07 +- 0.07

PF01427 (3/3) D-ala-D-ala dipeptidase
PF00293 (3/3) NUDIX domain
PF00005 (3/3) ABC transporter
PF01425 (2/3) Amidase
PF00069 (2/3) Protein kinase domain

jaccard_groups_5801

694.47 +- 44.47

0.01 +- 0.00

jaccard_groups_2297

226.23 +- 76.62

0.05 +- 0.04

TIGR00976 (10/10) hydrolase CocE/NonD family protein
PF08530 (10/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (10/10) alpha/beta hydrolase fold
PF02129 (10/10) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (10/10) Phosphotriesterase family
PF01494 (10/10) FAD binding domain
PF00753 (10/10) Metallo-beta-lactamase superfamily
PF07690 (9/10) Major Facilitator Superfamily
PF03781 (9/10) Sulfatase-modifying factor enzyme 1
PF00884 (9/10) Sulfatase

jaccard_groups_4385

113.39 +- 34.95

0.06 +- 0.10

PF13581 (4/4) Histidine kinase-like ATPase domain
PF07690 (4/4) Major Facilitator Superfamily
PF07681 (4/4) DoxX
PF02515 (4/4) CoA-transferase family III
PF01546 (4/4) Peptidase family M20/M25/M40
PF00903 (4/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (4/4) Enoyl-CoA hydratase/isomerase

jaccard_groups_4380

778.00 +- 2.83

0.01 +- 0.00

jaccard_groups_4068

234.00 +- 26.00

0.01 +- 0.01

jaccard_groups_3966

394.50 +- 74.31

0.02 +- 0.03

jaccard_groups_1140

593.76 +- 477.93

0.04 +- 0.08

TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (2/2) heavy metal translocating P-type ATPase
PF17197 (2/2) Domain of unknown function (DUF5134)
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF04314 (2/2) Copper chaperone PCu(A)C
PF03929 (2/2) PepSY-associated TM region
PF01965 (2/2) DJ-1/PfpI family
PF00702 (2/2) haloacid dehalogenase-like hydrolase
PF00403 (2/2) Heavy-metal-associated domain
PF00122 (2/2) E1-E2 ATPase
PF12833 (1/2) Helix-turn-helix domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00005 (1/2) ABC transporter

jaccard_groups_46

350.14 +- 165.86

0.02 +- 0.02

PF07729 (2/2) FCD domain
PF00392 (2/2) Bacterial regulatory proteins, gntR family
PF13714 (1/2) Phosphoenolpyruvate phosphomutase
PF13699 (1/2) Domain of unknown function (DUF4157)
PF13649 (1/2) Methyltransferase domain
PF07969 (1/2) Amidohydrolase family
PF01083 (1/2) Cutinase
PF00975 (1/2) Thioesterase domain
PF00248 (1/2) Aldo/keto reductase family

jaccard_groups_45

358.78 +- 294.16

0.01 +- 0.01

PF01494 (3/3) FAD binding domain

jaccard_groups_42

363.14 +- 500.69

0.03 +- 0.06

PF13193 (11/11) AMP-binding enzyme C-terminal domain
PF00501 (11/11) AMP-binding enzyme

jaccard_groups_4201

335.33 +- 121.62

0.04 +- 0.03

TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence
PF13377 (4/4) Periplasmic binding protein-like domain
PF02065 (4/4) Melibiase
PF01547 (4/4) Bacterial extracellular solute-binding protein
PF00652 (4/4) Ricin-type beta-trefoil lectin domain
PF00528 (4/4) Binding-protein-dependent transport system inner membrane component
PF00356 (4/4) Bacterial regulatory proteins, lacI family
PF12833 (3/4) Helix-turn-helix domain
PF01965 (3/4) DJ-1/PfpI family

jaccard_groups_1629

185.37 +- 61.16

0.09 +- 0.08

PF16875 (8/8) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (8/8) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (8/8) Enoyl-(Acyl carrier protein) reductase
PF13378 (8/8) Enolase C-terminal domain-like
PF08450 (8/8) SMP-30/Gluconolactonase/LRE-like region
PF07729 (8/8) FCD domain
PF02746 (8/8) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (8/8) Melibiase
PF01547 (8/8) Bacterial extracellular solute-binding protein
PF01081 (8/8) KDPG and KHG aldolase
PF00528 (8/8) Binding-protein-dependent transport system inner membrane component
PF00392 (8/8) Bacterial regulatory proteins, gntR family
PF00294 (8/8) pfkB family carbohydrate kinase
PF17801 (7/8) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (7/8) Alpha galactosidase A
PF00583 (6/8) Acetyltransferase (GNAT) family
TIGR01409 (4/8) Tat (twin-arginine translocation) pathway signal sequence

jaccard_groups_4707

77.60 +- 25.60

0.03 +- 0.02

jaccard_groups_5243

3120.00 +- 0.00

0.01 +- 0.00

jaccard_groups_3848

240.43 +- 106.11

0.01 +- 0.02

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme

jaccard_groups_881

363.96 +- 245.86

0.04 +- 0.02

TIGR00126 (3/3) deoxyribose-phosphate aldolase
PF13407 (3/3) Periplasmic binding protein domain
PF07702 (3/3) UTRA domain
PF05025 (3/3) RbsD / FucU transport protein family
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00005 (3/3) ABC transporter
PF02653 (2/3) Branched-chain amino acid transport system / permease component
PF00294 (2/3) pfkB family carbohydrate kinase

jaccard_groups_929

167.23 +- 13.37

0.06 +- 0.04

TIGR02138 (2/2) phosphate ABC transporter, permease protein PstC
TIGR00974 (2/2) phosphate ABC transporter, permease protein PstA
TIGR00972 (2/2) phosphate ABC transporter, ATP-binding protein
PF16640 (2/2) Bacterial Ig-like domain (group 3)
PF12849 (2/2) PBP superfamily domain
PF04203 (2/2) Sortase domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00041 (2/2) Fibronectin type III domain
PF00005 (2/2) ABC transporter
TIGR01076 (1/2) sortase
PF12833 (1/2) Helix-turn-helix domain
PF06719 (1/2) AraC-type transcriptional regulator N-terminus
PF00106 (1/2) short chain dehydrogenase

jaccard_groups_567

411.00 +- 239.00

0.01 +- 0.01

PF17390 (2/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (2/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF08531 (2/2) Alpha-L-rhamnosidase N-terminal domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF12146 (1/2) Serine aminopeptidase, S33
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05592 (1/2) Bacterial alpha-L-rhamnosidase concanavalin-like domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01979 (1/2) Amidohydrolase family
PF01494 (1/2) FAD binding domain
PF01483 (1/2) Proprotein convertase P-domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00754 (1/2) F5/8 type C domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00356 (1/2) Bacterial regulatory proteins, lacI family

jaccard_groups_5347

216.17 +- 107.83

0.04 +- 0.05

jaccard_groups_158

93.07 +- 22.71

0.03 +- 0.04

TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain
PF03816 (2/2) Cell envelope-related transcriptional attenuator domain
PF13641 (1/2) Glycosyltransferase like family 2
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF07730 (1/2) Histidine kinase
PF07366 (1/2) SnoaL-like polyketide cyclase
PF01522 (1/2) Polysaccharide deacetylase
PF00561 (1/2) alpha/beta hydrolase fold
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
PF00072 (1/2) Response regulator receiver domain

jaccard_groups_4964

454.25 +- 29.50

0.02 +- 0.02

jaccard_groups_4841

1530.48 +- 523.91

0.01 +- 0.03

PF05193 (3/3) Peptidase M16 inactive domain
PF01937 (3/3) Protein of unknown function DUF89
PF01326 (3/3) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (3/3) ABC-2 type transporter
PF00675 (3/3) Insulinase (Peptidase family M16)
PF00391 (3/3) PEP-utilising enzyme, mobile domain
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
PF00005 (3/3) ABC transporter
PF13649 (2/3) Methyltransferase domain
PF03965 (2/3) Penicillinase repressor
PF01475 (2/3) Ferric uptake regulator family
PF01435 (2/3) Peptidase family M48
PF00583 (2/3) Acetyltransferase (GNAT) family
PF00196 (2/3) Bacterial regulatory proteins, luxR family

jaccard_groups_4518

186.14 +- 8.86

0.03 +- 0.04

jaccard_groups_208

196.06 +- 138.24

0.03 +- 0.08

TIGR04269 (10/10) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (10/10) HEXXH motif domain
PF13676 (10/10) TIR domain
PF13424 (10/10) Tetratricopeptide repeat
PF13374 (10/10) Tetratricopeptide repeat
PF04055 (10/10) Radical SAM superfamily
PF00931 (8/10) NB-ARC domain
TIGR04268 (7/10) FXSXX-COOH protein
TIGR04276 (6/10) FxsC C-terminal domain
PF01656 (5/10) CobQ/CobB/MinD/ParA nucleotide binding domain

jaccard_groups_366

28.64 +- 10.40

0.09 +- 0.13

TIGR01701 (3/3) oxidoreductase alpha (molybdopterin) subunit
PF03364 (3/3) Polyketide cyclase / dehydrase and lipid transport
PF01568 (3/3) Molydopterin dinucleotide binding domain
PF00384 (3/3) Molybdopterin oxidoreductase
PF07077 (2/3) Protein of unknown function (DUF1345)

jaccard_groups_1996

411.81 +- 445.80

0.06 +- 0.08

TIGR01972 (5/5) proton-translocating NADH-quinone oxidoreductase, chain M
PF00507 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (5/5) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (5/5) Proton-conducting membrane transporter
PF00146 (5/5) NADH dehydrogenase

jaccard_groups_1363

650.00 +- 0.00

0.01 +- 0.00

PF13367 (2/2) PrsW family intramembrane metalloprotease

jaccard_groups_1360

40.01 +- 4.56

0.06 +- 0.06

PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (2/2) [2Fe-2S] binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
PF13191 (1/2) AAA ATPase domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family

jaccard_groups_3444

218.17 +- 57.06

0.05 +- 0.06

PF08386 (5/5) TAP-like protein
PF05532 (5/5) CsbD-like
PF05147 (5/5) Lanthionine synthetase C-like protein
PF00664 (5/5) ABC transporter transmembrane region
PF00561 (5/5) alpha/beta hydrolase fold
PF00069 (5/5) Protein kinase domain
PF00005 (5/5) ABC transporter
PF12697 (4/5) Alpha/beta hydrolase family
PF00117 (3/5) Glutamine amidotransferase class-I

jaccard_groups_6222

103.09 +- 21.09

0.06 +- 0.08

jaccard_groups_777

29.90 +- 5.84

0.08 +- 0.09

PF13516 (3/3) Leucine Rich repeat
PF13203 (3/3) Putative metallopeptidase domain
PF09967 (3/3) VWA-like domain (DUF2201)
PF07728 (3/3) AAA domain (dynein-related subfamily)

jaccard_groups_772

455.00 +- 195.00

0.01 +- 0.00

PF00246 (2/2) Zinc carboxypeptidase
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF00082 (1/2) Subtilase family

jaccard_groups_3664

174.93 +- 114.89

0.03 +- 0.05

jaccard_groups_3665

782.11 +- 340.79

0.01 +- 0.01

jaccard_groups_3660

174.02 +- 47.17

0.07 +- 0.10

jaccard_groups_1887

48.84 +- 15.40

0.09 +- 0.08

jaccard_groups_100

283.77 +- 123.70

0.04 +- 0.06

PF17964 (5/5) Bacterial Ig domain
PF03734 (5/5) L,D-transpeptidase catalytic domain

jaccard_groups_103

26.66 +- 3.06

0.07 +- 0.07

PF00652 (3/3) Ricin-type beta-trefoil lectin domain
PF00457 (2/3) Glycosyl hydrolases family 11
PF00331 (2/3) Glycosyl hydrolase family 10

jaccard_groups_102

712.17 +- 360.81

0.05 +- 0.13

TIGR03797 (9/9) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (9/9) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF03412 (9/9) Peptidase C39 family
PF00664 (9/9) ABC transporter transmembrane region
PF00005 (9/9) ABC transporter
PF13437 (8/9) HlyD family secretion protein
TIGR03882 (6/9) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (6/9) SagB-type dehydrogenase domain
TIGR03604 (6/9) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (6/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/9) Nitroreductase family

jaccard_groups_6357

166.79 +- 16.68

0.05 +- 0.06

jaccard_groups_6036

301.83 +- 85.17

0.01 +- 0.00

PF13620 (2/2) Carboxypeptidase regulatory-like domain
PF09861 (2/2) Lactate racemase N-terminal domain
PF04264 (2/2) YceI-like domain
PF00733 (2/2) Asparagine synthase
PF00731 (2/2) AIR carboxylase
PF00083 (2/2) Sugar (and other) transporter
TIGR00268 (1/2) TIGR00268 family protein

jaccard_groups_2768

935.22 +- 296.60

0.01 +- 0.00

jaccard_groups_2761

1099.00 +- 449.00

0.01 +- 0.00

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF09339 (3/3) IclR helix-turn-helix domain
PF01614 (3/3) Bacterial transcriptional regulator
PF00501 (3/3) AMP-binding enzyme
PF02515 (2/3) CoA-transferase family III
PF01144 (2/3) Coenzyme A transferase

jaccard_groups_4106

1105.00 +- 0.00

0.02 +- 0.00

jaccard_groups_2827

232.15 +- 115.15

0.02 +- 0.01

PF09339 (2/2) IclR helix-turn-helix domain
PF01614 (2/2) Bacterial transcriptional regulator
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF02525 (1/2) Flavodoxin-like fold
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

jaccard_groups_470

72.96 +- 100.25

0.06 +- 0.08

PF17866 (9/9) AAA lid domain
PF13229 (9/9) Right handed beta helix region
PF00652 (9/9) Ricin-type beta-trefoil lectin domain
PF00082 (9/9) Subtilase family
PF00004 (9/9) ATPase family associated with various cellular activities (AAA)

jaccard_groups_472

773.17 +- 20.67

0.01 +- 0.00

jaccard_groups_3804

698.76 +- 460.13

0.02 +- 0.03

PF10502 (3/3) Signal peptidase, peptidase S26
PF03704 (3/3) Bacterial transcriptional activator domain
PF00931 (3/3) NB-ARC domain
PF00717 (3/3) Peptidase S24-like
PF00486 (3/3) Transcriptional regulatory protein, C terminal
PF00005 (3/3) ABC transporter
PF07291 (2/3) Methylamine utilisation protein MauE
PF00899 (2/3) ThiF family

jaccard_groups_5425

800.15 +- 419.49

0.03 +- 0.02

TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17645 (2/2) Arylmalonate decarboxylase
PF09339 (2/2) IclR helix-turn-helix domain
PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region
PF02426 (2/2) Muconolactone delta-isomerase
PF01614 (2/2) Bacterial transcriptional regulator
PF01593 (2/2) Flavin containing amine oxidoreductase
PF01244 (2/2) Membrane dipeptidase (Peptidase family M19)
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (2/2) Aldehyde dehydrogenase family
PF00005 (2/2) ABC transporter
PF13489 (1/2) Methyltransferase domain
PF05685 (1/2) Putative restriction endonuclease
PF04978 (1/2) Protein of unknown function (DUF664)

jaccard_groups_2234

1001.47 +- 887.78

0.05 +- 0.18

jaccard_groups_4083

30.46 +- 5.65

0.07 +- 0.12

jaccard_groups_1584

116.33 +- 25.07

0.04 +- 0.04

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

jaccard_groups_2239

192.15 +- 49.28

0.03 +- 0.04

TIGR01910 (3/3) peptidase, ArgE/DapE family
PF01546 (3/3) Peptidase family M20/M25/M40
PF01510 (3/3) N-acetylmuramoyl-L-alanine amidase
PF00107 (2/3) Zinc-binding dehydrogenase

jaccard_groups_4327

217.10 +- 169.90

0.04 +- 0.10

TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (2/2) Bacterial Ig domain
PF14864 (2/2) Alkyl sulfatase C-terminal
PF14863 (2/2) Alkyl sulfatase dimerisation
PF08281 (2/2) Sigma-70, region 4
PF04542 (2/2) Sigma-70 region 2
PF03734 (2/2) L,D-transpeptidase catalytic domain
PF00753 (2/2) Metallo-beta-lactamase superfamily
PF00912 (1/2) Transglycosylase

jaccard_groups_1062

855.25 +- 692.75

0.02 +- 0.04

PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF00501 (2/2) AMP-binding enzyme
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF13622 (1/2) Thioesterase-like superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01613 (1/2) Flavin reductase like domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00106 (1/2) short chain dehydrogenase

jaccard_groups_4424

1191.19 +- 1181.25

0.05 +- 0.18

TIGR03605 (4/4) SagB-type dehydrogenase domain
TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase
PF08241 (4/4) Methyltransferase domain
PF07993 (4/4) Male sterility protein
PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport
PF03176 (4/4) MMPL family
PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain
PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (4/4) Nitroreductase family
PF00698 (4/4) Acyl transferase domain
PF00550 (4/4) Phosphopantetheine attachment site
PF00202 (4/4) Aminotransferase class-III
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain
TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain
PF03473 (3/4) MOSC domain
PF01575 (3/4) MaoC like domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF05193 (2/4) Peptidase M16 inactive domain
PF03476 (2/4) MOSC N-terminal beta barrel domain
PF00106 (2/4) short chain dehydrogenase

jaccard_groups_1497

200.79 +- 26.57

0.07 +- 0.11

TIGR01182 (5/5) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (5/5) Domain of unknown function (DUF4380)
PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase
PF13407 (5/5) Periplasmic binding protein domain
PF13378 (5/5) Enolase C-terminal domain-like
PF08450 (5/5) SMP-30/Gluconolactonase/LRE-like region
PF08240 (5/5) Alcohol dehydrogenase GroES-like domain
PF07729 (5/5) FCD domain
PF02746 (5/5) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (5/5) Branched-chain amino acid transport system / permease component
PF01081 (5/5) KDPG and KHG aldolase
PF00392 (5/5) Bacterial regulatory proteins, gntR family
PF00294 (5/5) pfkB family carbohydrate kinase
PF00107 (5/5) Zinc-binding dehydrogenase
PF00005 (5/5) ABC transporter

jaccard_groups_608

59.27 +- 22.81

0.04 +- 0.07

jaccard_groups_601

243.14 +- 234.27

0.03 +- 0.04

PF07690 (31/31) Major Facilitator Superfamily
PF04055 (30/31) Radical SAM superfamily
PF00326 (28/31) Prolyl oligopeptidase family
PF02310 (19/31) B12 binding domain
TIGR03975 (16/31) ribosomal peptide maturation radical SAM protein 1

jaccard_groups_604

347.75 +- 199.45

0.04 +- 0.06

PF09084 (6/6) NMT1/THI5 like
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component
PF00005 (6/6) ABC transporter

jaccard_groups_1669

63.45 +- 1.05

0.06 +- 0.06

jaccard_groups_2530

151.10 +- 35.76

0.03 +- 0.03

PF07702 (3/3) UTRA domain
PF03747 (3/3) ADP-ribosylglycohydrolase
PF02133 (3/3) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (3/3) Bacterial regulatory proteins, gntR family
PF00294 (3/3) pfkB family carbohydrate kinase
PF04672 (2/3) S-adenosyl methyltransferase

jaccard_groups_1943

280.13 +- 235.87

0.05 +- 0.16

jaccard_groups_92

934.57 +- 552.23

0.03 +- 0.04

PF01547 (6/6) Bacterial extracellular solute-binding protein
PF00528 (6/6) Binding-protein-dependent transport system inner membrane component

jaccard_groups_4557

93.44 +- 9.76

0.04 +- 0.07

jaccard_groups_98

355.79 +- 204.29

0.07 +- 0.20

PF00691 (8/8) OmpA family
PF00482 (8/8) Type II secretion system (T2SS), protein F
PF13400 (7/8) Putative Flp pilus-assembly TadE/G-like
PF07730 (7/8) Histidine kinase
PF00196 (7/8) Bacterial regulatory proteins, luxR family
PF00072 (7/8) Response regulator receiver domain
TIGR03177 (6/8) Flp pilus assembly protein CpaB
PF16976 (6/8) Flp pilus assembly protein RcpC/CpaB
PF13614 (6/8) AAA domain
PF07811 (6/8) TadE-like protein
PF00437 (6/8) Type II/IV secretion system protein

jaccard_groups_99

136.23 +- 121.23

0.05 +- 0.05

PF00296 (8/8) Luciferase-like monooxygenase
PF07690 (5/8) Major Facilitator Superfamily
PF00106 (5/8) short chain dehydrogenase

jaccard_groups_4632

322.38 +- 56.79

0.02 +- 0.02

jaccard_groups_694

297.75 +- 125.22

0.02 +- 0.03

jaccard_groups_914

396.80 +- 256.32

0.06 +- 0.15

TIGR03945 (12/12) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (12/12) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (12/12) amino acid adenylation domain
PF13193 (12/12) AMP-binding enzyme C-terminal domain
PF03621 (12/12) MbtH-like protein
PF02423 (12/12) Ornithine cyclodeaminase/mu-crystallin family
PF00975 (12/12) Thioesterase domain
PF00668 (12/12) Condensation domain
PF00550 (12/12) Phosphopantetheine attachment site
PF00501 (12/12) AMP-binding enzyme
PF00291 (12/12) Pyridoxal-phosphate dependent enzyme
TIGR01720 (11/12) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (11/12) daunorubicin resistance ABC transporter, ATP-binding protein
PF01061 (11/12) ABC-2 type transporter
PF00005 (11/12) ABC transporter
PF13732 (9/12) Domain of unknown function (DUF4162)

jaccard_groups_5629

777.00 +- 3.00

0.01 +- 0.00

jaccard_groups_3938

618.09 +- 123.82

0.01 +- 0.02

jaccard_groups_850

167.70 +- 38.70

0.01 +- 0.01

PF12802 (2/2) MarR family
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00583 (2/2) Acetyltransferase (GNAT) family
PF05977 (1/2) Transmembrane secretion effector

jaccard_groups_3930

194.50 +- 52.12

0.07 +- 0.08

jaccard_groups_324

298.27 +- 161.74

0.06 +- 0.08

TIGR00976 (5/5) hydrolase CocE/NonD family protein
PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family)
PF00005 (5/5) ABC transporter
PF00664 (4/5) ABC transporter transmembrane region
PF01497 (3/5) Periplasmic binding protein
PF01032 (3/5) FecCD transport family

jaccard_groups_859

261.24 +- 116.32

0.02 +- 0.03

TIGR01746 (4/4) thioester reductase domain
PF07993 (4/4) Male sterility protein
PF00550 (4/4) Phosphopantetheine attachment site
PF00501 (4/4) AMP-binding enzyme
PF13193 (3/4) AMP-binding enzyme C-terminal domain
PF00300 (3/4) Histidine phosphatase superfamily (branch 1)
PF00196 (3/4) Bacterial regulatory proteins, luxR family

jaccard_groups_2998

276.85 +- 62.50

0.02 +- 0.02

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family

jaccard_groups_4951

609.27 +- 165.86

0.01 +- 0.00

jaccard_groups_1200

423.60 +- 111.96

0.05 +- 0.16

TIGR01850 (20/20) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (20/20) RimK-like ATP-grasp domain
PF02779 (20/20) Transketolase, pyrimidine binding domain
PF01118 (20/20) Semialdehyde dehydrogenase, NAD binding domain
PF00456 (20/20) Transketolase, thiamine diphosphate binding domain
TIGR01902 (19/20) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (19/20) Peptidase family M20/M25/M40
PF01041 (19/20) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (19/20) Amino acid kinase family
TIGR00768 (16/20) alpha-L-glutamate ligase, RimK family
PF18603 (15/20) L-amino acid ligase C-terminal domain 2
PF18130 (15/20) ATP-grasp N-terminal domain
PF13535 (15/20) ATP-grasp domain
PF07690 (15/20) Major Facilitator Superfamily

jaccard_groups_1201

304.78 +- 169.03

0.02 +- 0.11

TIGR01554 (5/5) phage major capsid protein, HK97 family
TIGR01543 (5/5) phage prohead protease, HK97 family
TIGR01537 (5/5) phage portal protein, HK97 family
PF05065 (5/5) Phage capsid family
PF04860 (5/5) Phage portal protein
PF04586 (5/5) Caudovirus prohead serine protease
PF01844 (5/5) HNH endonuclease
PF01510 (5/5) N-acetylmuramoyl-L-alanine amidase
PF09250 (3/5) Bifunctional DNA primase/polymerase, N-terminal

jaccard_groups_5019

143.00 +- 117.00

0.04 +- 0.07

PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00931 (2/2) NB-ARC domain

jaccard_groups_5018

260.13 +- 5.78

0.02 +- 0.01

jaccard_groups_4815

129.50 +- 0.50

0.02 +- 0.00

jaccard_groups_3439

960.72 +- 458.28

0.02 +- 0.02

jaccard_groups_3436

105.42 +- 39.62

0.06 +- 0.04

TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family
PF08281 (3/3) Sigma-70, region 4
PF07883 (3/3) Cupin domain
PF07690 (3/3) Major Facilitator Superfamily
PF04542 (3/3) Sigma-70 region 2
PF01966 (3/3) HD domain
TIGR00778 (2/3) alkylhydroperoxidase AhpD family core domain
PF08240 (2/3) Alcohol dehydrogenase GroES-like domain
PF02627 (2/3) Carboxymuconolactone decarboxylase family
PF00107 (2/3) Zinc-binding dehydrogenase

jaccard_groups_823

258.00 +- 0.00

0.01 +- 0.00

PF01656 (2/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01234 (2/2) NNMT/PNMT/TEMT family

jaccard_groups_826

124.87 +- 85.22

0.03 +- 0.03

TIGR01840 (5/5) esterase, PHB depolymerase family
TIGR00666 (5/5) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF14016 (5/5) Protein of unknown function (DUF4232)
PF10503 (5/5) Esterase PHB depolymerase
PF02113 (5/5) D-Ala-D-Ala carboxypeptidase 3 (S13) family

jaccard_groups_3322

66.72 +- 9.38

0.06 +- 0.01

TIGR01746 (2/2) thioester reductase domain
TIGR01733 (2/2) amino acid adenylation domain
PF18130 (2/2) ATP-grasp N-terminal domain
PF13640 (2/2) 2OG-Fe(II) oxygenase superfamily
PF13535 (2/2) ATP-grasp domain
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF07993 (2/2) Male sterility protein
PF05118 (2/2) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00106 (2/2) short chain dehydrogenase

jaccard_groups_559

532.21 +- 472.81

0.02 +- 0.07

TIGR03882 (4/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (4/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF02624 (4/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF07730 (3/5) Histidine kinase
PF00196 (3/5) Bacterial regulatory proteins, luxR family
PF00072 (3/5) Response regulator receiver domain

jaccard_groups_556

128.36 +- 9.29

0.03 +- 0.03

PF00553 (2/2) Cellulose binding domain
PF00150 (2/2) Cellulase (glycosyl hydrolase family 5)
PF00041 (2/2) Fibronectin type III domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF07944 (1/2) Beta-L-arabinofuranosidase, GH127
PF01757 (1/2) Acyltransferase family
PF00545 (1/2) ribonuclease

Entry name	Average score	Number of operons	Number of MIBiG operons	Number of operons with antismash overlap	Nr of operons with known RiPP domains	Average COG score	Nr of operons passed filter	Common domains
precursor_jaccard_groups_37731	1554.00 +- 6.00	2	0	2	0	0.01 +- 0.00	2	7 PF08007 (2/2) Cupin superfamily protein PF03412 (2/2) Peptidase C39 family PF00668 (2/2) Condensation domain PF00664 (2/2) ABC transporter transmembrane region PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00005 (2/2) ABC transporter
precursor_jaccard_groups_9969	409.86 +- 183.82	5	0	5	0	0.02 +- 0.01	5	10 PF13450 (5/5) NAD(P)-binding Rossmann-like domain PF07690 (5/5) Major Facilitator Superfamily PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH) PF02668 (5/5) Taurine catabolism dioxygenase TauD, TfdA family PF00743 (5/5) Flavin-binding monooxygenase-like PF00348 (5/5) Polyprenyl synthetase PF00106 (5/5) short chain dehydrogenase TIGR01534 (3/5) glyceraldehyde-3-phosphate dehydrogenase, type I PF02800 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PF00044 (3/5) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
precursor_jaccard_groups_1147	339.13 +- 0.00	2	0	0	0	0.03 +- 0.01	2	8 TIGR00574 (2/2) DNA ligase I, ATP-dependent (dnl1) PF04679 (2/2) ATP dependent DNA ligase C terminal region PF04675 (2/2) DNA ligase N terminus PF01547 (2/2) Bacterial extracellular solute-binding protein PF01380 (2/2) SIS domain PF01068 (2/2) ATP dependent DNA ligase domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_1146	328.63 +- 21.56	3	0	3	3	0.03 +- 0.03	3	4 PF13471 (3/3) Transglutaminase-like superfamily PF01546 (3/3) Peptidase family M20/M25/M40 PF00733 (3/3) Asparagine synthase PF00005 (3/3) ABC transporter
precursor_jaccard_groups_26551	258.09 +- 86.03	2	0	0	2	0.03 +- 0.05	2	13 PF17676 (2/2) LD-carboxypeptidase C-terminal domain PF13581 (2/2) Histidine kinase-like ATPase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13280 (2/2) WYL domain PF08279 (2/2) HTH domain PF04055 (2/2) Radical SAM superfamily PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family PF02310 (2/2) B12 binding domain PF02016 (2/2) LD-carboxypeptidase N-terminal domain PF00730 (2/2) HhH-GPD superfamily base excision DNA repair protein PF00293 (2/2) NUDIX domain PF00152 (2/2) tRNA synthetases class II (D, K and N) PF00005 (2/2) ABC transporter
precursor_jaccard_groups_22017	275.37 +- 49.63	2	0	0	0	0.02 +- 0.02	2	8 TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16884 (2/2) N-terminal domain of oxidoreductase PF12146 (2/2) Serine aminopeptidase, S33 PF07690 (2/2) Major Facilitator Superfamily PF06441 (2/2) Epoxide hydrolase N terminus PF00561 (2/2) alpha/beta hydrolase fold PF00107 (2/2) Zinc-binding dehydrogenase PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_41746	135.53 +- 39.47	2	0	0	0	0.06 +- 0.09	2	9 TIGR02983 (2/2) RNA polymerase sigma-70 factor, sigma-E family PF17964 (2/2) Bacterial Ig domain PF13411 (2/2) MerR HTH family regulatory protein PF08281 (2/2) Sigma-70, region 4 PF07739 (2/2) TipAS antibiotic-recognition domain PF04542 (2/2) Sigma-70 region 2 PF03734 (2/2) L,D-transpeptidase catalytic domain PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_13838	595.57 +- 149.62	4	0	4	0	0.01 +- 0.00	4	17 TIGR01509 (4/4) HAD hydrolase, family IA, variant 3 PF18181 (4/4) SMODS and SLOG-associating 2TM effector domain 1 PF16864 (4/4) Dimerisation domain PF14015 (4/4) Protein of unknown function (DUF4231) PF13692 (4/4) Glycosyl transferases group 1 PF13676 (4/4) TIR domain PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13419 (4/4) Haloacid dehalogenase-like hydrolase PF13292 (4/4) 1-deoxy-D-xylulose-5-phosphate synthase PF12464 (4/4) Maltose acetyltransferase PF11941 (4/4) Domain of unknown function (DUF3459) PF07728 (4/4) AAA domain (dynein-related subfamily) PF05729 (4/4) NACHT domain PF01636 (4/4) Phosphotransferase enzyme family PF00891 (4/4) O-methyltransferase domain PF00202 (4/4) Aminotransferase class-III PF00132 (4/4) Bacterial transferase hexapeptide (six repeats)
precursor_jaccard_groups_33956	134.01 +- 78.72	2	0	2	2	0.06 +- 0.05	2	9 PF13471 (2/2) Transglutaminase-like superfamily PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (2/2) Asparagine synthase PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter TIGR03696 (1/2) RHS repeat-associated core domain TIGR01643 (1/2) YD repeat (two copies) PF07591 (1/2) Pretoxin HINT domain PF05593 (1/2) RHS Repeat
precursor_jaccard_groups_19591	172.00 +- 60.81	3	0	0	0	0.01 +- 0.00	3	2 PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF00107 (3/3) Zinc-binding dehydrogenase
precursor_jaccard_groups_21824	303.16 +- 34.84	2	0	0	0	0.06 +- 0.10	2	19 TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family TIGR02980 (2/2) RNA polymerase sigma-70 factor, sigma-B/F/G subfamily PF14310 (2/2) Fibronectin type III-like domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13529 (2/2) Peptidase_C39 like family PF12697 (2/2) Alpha/beta hydrolase family PF07729 (2/2) FCD domain PF06684 (2/2) Amino acid synthesis PF04545 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF04539 (2/2) Sigma-70 region 3 PF03547 (2/2) Membrane transport protein PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00296 (2/2) Luciferase-like monooxygenase PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_10625	502.26 +- 347.48	5	0	5	0	0.05 +- 0.18	5	17 TIGR01509 (5/5) HAD hydrolase, family IA, variant 3 PF13419 (5/5) Haloacid dehalogenase-like hydrolase PF13191 (5/5) AAA ATPase domain PF12710 (5/5) haloacid dehalogenase-like hydrolase PF07690 (5/5) Major Facilitator Superfamily PF04321 (5/5) RmlD substrate binding domain PF01979 (5/5) Amidohydrolase family PF00535 (5/5) Glycosyl transferase family 2 PF00480 (5/5) ROK family PF00459 (5/5) Inositol monophosphatase family PF00294 (5/5) pfkB family carbohydrate kinase PF00202 (5/5) Aminotransferase class-III PF00196 (5/5) Bacterial regulatory proteins, luxR family PF13632 (4/5) Glycosyl transferase family group 2 TIGR00178 (3/5) isocitrate dehydrogenase, NADP-dependent PF03971 (3/5) Monomeric isocitrate dehydrogenase PF00903 (3/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_541	144.49 +- 22.80	12	0	12	12	0.02 +- 0.02	12	4 PF07690 (12/12) Major Facilitator Superfamily PF04055 (12/12) Radical SAM superfamily PF02897 (12/12) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (12/12) Prolyl oligopeptidase family
precursor_jaccard_groups_2197	1001.47 +- 887.78	16	0	12	0	0.05 +- 0.18	16	18 PF13535 (16/16) ATP-grasp domain PF13480 (16/16) Acetyltransferase (GNAT) domain PF13115 (16/16) YtkA-like PF04389 (16/16) Peptidase family M28 PF02627 (16/16) Carboxymuconolactone decarboxylase family PF00664 (16/16) ABC transporter transmembrane region PF00403 (16/16) Heavy-metal-associated domain PF00155 (16/16) Aminotransferase class I and II PF00005 (16/16) ABC transporter TIGR01525 (15/16) heavy metal translocating P-type ATPase TIGR01307 (15/16) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF13549 (15/16) ATP-grasp domain PF01676 (15/16) Metalloenzyme superfamily PF00702 (15/16) haloacid dehalogenase-like hydrolase PF00275 (15/16) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00122 (15/16) E1-E2 ATPase PF00117 (15/16) Glutamine amidotransferase class-I TIGR01356 (14/16) 3-phosphoshikimate 1-carboxyvinyltransferase
precursor_jaccard_groups_3842	1010.92 +- 468.30	4	0	0	4	0.03 +- 0.04	4	25 TIGR03812 (4/4) tyrosine decarboxylase MnfA PF17755 (4/4) UvrA DNA-binding domain PF16861 (4/4) Carbamoyltransferase C-terminus PF16169 (4/4) Domain of unknown function (DUF4872) PF14399 (4/4) Butirosin biosynthesis protein H, N-terminal PF13370 (4/4) 4Fe-4S single cluster domain of Ferredoxin I PF11794 (4/4) 4-hydroxyphenylacetate 3-hydroxylase N terminal PF08713 (4/4) DNA alkylation repair enzyme PF08241 (4/4) Methyltransferase domain PF04879 (4/4) Molybdopterin oxidoreductase Fe4S4 domain PF04055 (4/4) Radical SAM superfamily PF03241 (4/4) 4-hydroxyphenylacetate 3-hydroxylase C terminal PF02543 (4/4) Carbamoyltransferase N-terminus PF02310 (4/4) B12 binding domain PF02195 (4/4) ParB-like nuclease domain PF01613 (4/4) Flavin reductase like domain PF01568 (4/4) Molydopterin dinucleotide binding domain PF01061 (4/4) ABC-2 type transporter PF00805 (4/4) Pentapeptide repeats (8 copies) PF00795 (4/4) Carbon-nitrogen hydrolase PF00384 (4/4) Molybdopterin oxidoreductase PF00291 (4/4) Pyridoxal-phosphate dependent enzyme PF00282 (4/4) Pyridoxal-dependent decarboxylase conserved domain PF00005 (4/4) ABC transporter PF00501 (3/4) AMP-binding enzyme
precursor_jaccard_groups_21306	100.33 +- 20.27	3	0	0	0	0.02 +- 0.02	3	3 PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08924 (3/3) Domain of unknown function (DUF1906) PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_10192	140.89 +- 0.00	2	0	2	2	0.10 +- 0.08	2	12 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (2/2) SagB-type dehydrogenase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00931 (2/2) NB-ARC domain PF00881 (2/2) Nitroreductase family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_jaccard_groups_44567	117.34 +- 48.52	2	0	2	0	0.03 +- 0.04	2	4 PF07883 (2/2) Cupin domain PF01872 (2/2) RibD C-terminal domain PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_6296	122.10 +- 43.38	4	0	0	0	0.05 +- 0.04	4	12 TIGR03945 (4/4) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (4/4) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01891 (4/4) amidohydrolase TIGR00843 (4/4) benzoate transporter PF13454 (4/4) FAD-NAD(P)-binding PF13424 (4/4) Tetratricopeptide repeat PF03594 (4/4) Benzoate membrane transport protein PF02423 (4/4) Ornithine cyclodeaminase/mu-crystallin family PF01546 (4/4) Peptidase family M20/M25/M40 PF01053 (4/4) Cys/Met metabolism PLP-dependent enzyme PF00931 (4/4) NB-ARC domain PF00291 (4/4) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_30675	259.00 +- 1.00	2	0	0	0	0.01 +- 0.00	2	3 PF07859 (2/2) alpha/beta hydrolase fold PF00175 (2/2) Oxidoreductase NAD-binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_30676	777.00 +- 3.00	2	0	0	0	0.01 +- 0.00	2	7 PF09339 (2/2) IclR helix-turn-helix domain PF07690 (2/2) Major Facilitator Superfamily PF01614 (2/2) Bacterial transcriptional regulator PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00557 (2/2) Metallopeptidase family M24 PF00355 (2/2) Rieske [2Fe-2S] domain PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_18596	377.27 +- 142.73	2	0	0	0	0.02 +- 0.01	2	9 TIGR03930 (2/2) WXG100 family type VII secretion target TIGR03920 (2/2) type VII secretion integral membrane protein EccD TIGR03919 (2/2) type VII secretion protein EccB PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD PF07202 (2/2) T-complex protein 10 C-terminus PF06013 (2/2) Proteins of 100 residues with WXG PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B PF02575 (2/2) YbaB/EbfC DNA-binding family PF00652 (2/2) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_18227	763.96 +- 609.16	2	0	2	1	0.05 +- 0.14	2	24 TIGR03696 (2/2) RHS repeat-associated core domain TIGR03494 (2/2) salicylate synthase TIGR02185 (2/2) putative ECF transporter S component, Trep_Strep family TIGR01733 (2/2) amino acid adenylation domain TIGR01643 (2/2) YD repeat (two copies) TIGR01443 (2/2) intein C-terminal splicing region PF13193 (2/2) AMP-binding enzyme C-terminal domain PF09605 (2/2) Hypothetical bacterial integral membrane protein (Trep_Strep) PF07591 (2/2) Pretoxin HINT domain PF05593 (2/2) RHS Repeat PF03704 (2/2) Bacterial transcriptional activator domain PF02361 (2/2) Cobalt transport protein PF00975 (2/2) Thioesterase domain PF00931 (2/2) NB-ARC domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00425 (2/2) chorismate binding enzyme PF00005 (2/2) ABC transporter TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing) PF13537 (1/2) Glutamine amidotransferase domain PF00733 (1/2) Asparagine synthase PF00664 (1/2) ABC transporter transmembrane region
precursor_jaccard_groups_35157	77.60 +- 25.60	2	0	0	0	0.03 +- 0.02	2	6 PF14525 (2/2) AraC-binding-like domain PF12833 (2/2) Helix-turn-helix domain PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF01551 (2/2) Peptidase family M23 PF01471 (2/2) Putative peptidoglycan binding domain PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_5311	552.84 +- 40.56	2	0	2	0	0.07 +- 0.18	2	28 TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase TIGR01733 (2/2) amino acid adenylation domain TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720 TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein PF13732 (2/2) Domain of unknown function (DUF4162) PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13279 (2/2) Thioesterase-like superfamily PF13193 (2/2) AMP-binding enzyme C-terminal domain PF13160 (2/2) Protein of unknown function (DUF3995) PF12146 (2/2) Serine aminopeptidase, S33 PF07977 (2/2) FabA-like domain PF06368 (2/2) Methylaspartate mutase E chain (MutE) PF03621 (2/2) MbtH-like protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family PF02310 (2/2) B12 binding domain PF01323 (2/2) DSBA-like thioredoxin domain PF01061 (2/2) ABC-2 type transporter PF00975 (2/2) Thioesterase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00291 (2/2) Pyridoxal-phosphate dependent enzyme PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (2/2) ABC transporter PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_269	297.75 +- 125.22	3	0	0	3	0.02 +- 0.03	3	10 TIGR03859 (3/3) coenzyme PQQ biosynthesis protein PqqD TIGR02111 (3/3) coenzyme PQQ biosynthesis protein C TIGR02109 (3/3) coenzyme PQQ biosynthesis enzyme PqqE PF13186 (3/3) Iron-sulfur cluster-binding domain PF12706 (3/3) Beta-lactamase superfamily domain PF07995 (3/3) Glucose / Sorbosone dehydrogenase PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (3/3) Radical SAM superfamily PF03070 (3/3) TENA/THI-4/PQQC family TIGR02107 (2/3) coenzyme PQQ precursor peptide PqqA
precursor_jaccard_groups_783	148.42 +- 88.47	10	0	0	10	0.03 +- 0.02	10	3 PF13649 (10/10) Methyltransferase domain PF07690 (10/10) Major Facilitator Superfamily PF04055 (10/10) Radical SAM superfamily
precursor_jaccard_groups_26178	773.17 +- 20.67	2	0	0	0	0.01 +- 0.00	2	8 TIGR01926 (2/2) uncharacterized peroxidase-related enzyme PF13454 (2/2) FAD-NAD(P)-binding PF13343 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF02627 (2/2) Carboxymuconolactone decarboxylase family PF01244 (2/2) Membrane dipeptidase (Peptidase family M19) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_jaccard_groups_464	1062.51 +- 1018.52	46	5	41	45	0.03 +- 0.09	41	7 TIGR03897 (45/46) type 2 lantibiotic biosynthesis protein LanM PF13575 (45/46) Domain of unknown function (DUF4135) PF05147 (45/46) Lanthionine synthetase C-like protein PF03412 (45/46) Peptidase C39 family PF00664 (45/46) ABC transporter transmembrane region PF00005 (45/46) ABC transporter PF14867 (41/46) Lantibiotic alpha
precursor_jaccard_groups_6724	593.52 +- 220.55	6	0	6	6	0.02 +- 0.04	6	10 TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF08007 (6/6) Cupin superfamily protein PF05147 (6/6) Lanthionine synthetase C-like protein PF04738 (6/6) Lantibiotic dehydratase, N terminus PF00664 (6/6) ABC transporter transmembrane region PF00005 (6/6) ABC transporter TIGR01317 (3/6) glutamate synthase, NADH/NADPH, small subunit PF14691 (3/6) Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster PF07992 (3/6) Pyridine nucleotide-disulphide oxidoreductase
precursor_jaccard_groups_19927	240.43 +- 106.11	3	0	3	0	0.01 +- 0.02	3	4 TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme PF01266 (3/3) FAD dependent oxidoreductase PF01019 (3/3) Gamma-glutamyltranspeptidase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_10697	52.65 +- 10.40	3	0	0	0	0.06 +- 0.07	3	5 PF13460 (3/3) NAD(P)H-binding PF08592 (3/3) Domain of unknown function (DUF1772) PF01814 (3/3) Hemerythrin HHE cation binding domain PF12852 (2/3) Cupin PF12833 (2/3) Helix-turn-helix domain
precursor_jaccard_groups_2900	258.67 +- 0.94	3	0	0	0	0.01 +- 0.00	3	2 PF01757 (3/3) Acyltransferase family PF00248 (3/3) Aldo/keto reductase family
precursor_jaccard_groups_14447	32.13 +- 5.78	3	0	0	0	0.06 +- 0.11	3	6 TIGR01509 (3/3) HAD hydrolase, family IA, variant 3 PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF08386 (3/3) TAP-like protein PF04149 (3/3) Domain of unknown function (DUF397) PF02388 (3/3) FemAB family PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_38006	362.00 +- 154.00	2	0	2	0	0.01 +- 0.01	2	2 PF08291 (2/2) Peptidase M15 PF01471 (2/2) Putative peptidoglycan binding domain
precursor_jaccard_groups_20439	197.39 +- 31.14	3	0	0	0	0.07 +- 0.11	3	15 TIGR01182 (3/3) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (3/3) Domain of unknown function (DUF4380) PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF13407 (3/3) Periplasmic binding protein domain PF13378 (3/3) Enolase C-terminal domain-like PF08450 (3/3) SMP-30/Gluconolactonase/LRE-like region PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF07729 (3/3) FCD domain PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (3/3) Branched-chain amino acid transport system / permease component PF01081 (3/3) KDPG and KHG aldolase PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00294 (3/3) pfkB family carbohydrate kinase PF00107 (3/3) Zinc-binding dehydrogenase PF00005 (3/3) ABC transporter
precursor_jaccard_groups_17446	249.70 +- 143.29	3	0	0	0	0.05 +- 0.05	3	18 TIGR03425 (3/3) urea carboxylase-associated protein 2 TIGR03424 (3/3) urea carboxylase-associated protein 1 TIGR02712 (3/3) urea carboxylase TIGR01930 (3/3) acetyl-CoA C-acyltransferase TIGR01509 (3/3) HAD hydrolase, family IA, variant 3 PF13520 (3/3) Amino acid permease PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF09347 (3/3) Domain of unknown function (DUF1989) PF02803 (3/3) Thiolase, C-terminal domain PF02786 (3/3) Carbamoyl-phosphate synthase L chain, ATP binding domain PF02785 (3/3) Biotin carboxylase C-terminal domain PF02682 (3/3) Carboxyltransferase domain, subdomain C and D PF02626 (3/3) Carboxyltransferase domain, subdomain A and B PF01425 (3/3) Amidase PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00364 (3/3) Biotin-requiring enzyme PF00289 (3/3) Biotin carboxylase, N-terminal domain PF00108 (3/3) Thiolase, N-terminal domain
precursor_jaccard_groups_1560	323.00 +- 111.43	4	0	0	4	0.01 +- 0.00	4	10 TIGR04276 (4/4) FxsC C-terminal domain TIGR04269 (4/4) radical SAM/SPASM domain protein, FxsB family TIGR04267 (4/4) HEXXH motif domain PF13676 (4/4) TIR domain PF13424 (4/4) Tetratricopeptide repeat PF13374 (4/4) Tetratricopeptide repeat PF04055 (4/4) Radical SAM superfamily PF01656 (4/4) CobQ/CobB/MinD/ParA nucleotide binding domain PF00931 (4/4) NB-ARC domain TIGR04268 (2/4) FXSXX-COOH protein
precursor_jaccard_groups_27278	518.00 +- 2.00	2	0	2	0	0.01 +- 0.00	2	6 PF03412 (2/2) Peptidase C39 family PF00668 (2/2) Condensation domain PF00664 (2/2) ABC transporter transmembrane region PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1568	143.45 +- 42.27	2	0	2	0	0.03 +- 0.04	2	10 PF13649 (2/2) Methyltransferase domain PF13450 (2/2) NAD(P)-binding Rossmann-like domain PF12697 (2/2) Alpha/beta hydrolase family PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter PF09339 (1/2) IclR helix-turn-helix domain PF07730 (1/2) Histidine kinase PF01636 (1/2) Phosphotransferase enzyme family PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_17965	287.08 +- 232.92	2	0	2	2	0.04 +- 0.10	2	7 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF07730 (2/2) Histidine kinase PF06722 (2/2) Protein of unknown function (DUF1205) PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_13164	98.93 +- 27.86	3	0	3	0	0.05 +- 0.05	3	6 PF18085 (3/3) Maltokinase N-terminal cap domain PF05547 (3/3) Immune inhibitor A peptidase M6 PF01433 (3/3) Peptidase family M1 domain PF08241 (2/3) Methyltransferase domain PF01183 (2/3) Glycosyl hydrolases family 25 PF00892 (2/3) EamA-like transporter family
precursor_jaccard_groups_13300	237.00 +- 29.70	3	0	3	0	0.01 +- 0.00	3	9 TIGR01733 (3/3) amino acid adenylation domain PF13193 (3/3) AMP-binding enzyme C-terminal domain PF12680 (3/3) SnoaL-like domain PF08242 (3/3) Methyltransferase domain PF07883 (3/3) Cupin domain PF00975 (3/3) Thioesterase domain PF00668 (3/3) Condensation domain PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme
precursor_jaccard_groups_2765	106.36 +- 66.97	2	0	0	0	0.03 +- 0.06	2	6 PF03965 (2/2) Penicillinase repressor PF01435 (2/2) Peptidase family M48 PF00403 (2/2) Heavy-metal-associated domain PF12229 (1/2) Putative peptidoglycan binding domain PF04294 (1/2) VanW like protein PF00877 (1/2) NlpC/P60 family
precursor_jaccard_groups_7819	34.94 +- 12.33	2	0	0	0	0.07 +- 0.06	2	2 PF13673 (2/2) Acetyltransferase (GNAT) domain PF01872 (2/2) RibD C-terminal domain
precursor_jaccard_groups_1063	86.80 +- 20.88	3	0	0	0	0.05 +- 0.06	3	5 PF14534 (3/3) Domain of unknown function (DUF4440) PF08002 (3/3) Protein of unknown function (DUF1697) PF05922 (3/3) Peptidase inhibitor I9 PF00082 (3/3) Subtilase family PF01323 (2/3) DSBA-like thioredoxin domain
precursor_jaccard_groups_7953	169.73 +- 174.91	6	0	0	0	0.05 +- 0.09	6	10 TIGR00229 (6/6) PAS domain S-box protein PF08448 (6/6) PAS fold PF08220 (6/6) DeoR-like helix-turn-helix domain PF07228 (6/6) Stage II sporulation protein E (SpoIIE) PF02909 (6/6) Tetracyclin repressor-like, C-terminal domain PF01590 (6/6) GAF domain PF00455 (6/6) DeoR C terminal sensor domain PF00440 (6/6) Bacterial regulatory proteins, tetR family PF00069 (6/6) Protein kinase domain PF01494 (3/6) FAD binding domain
precursor_jaccard_groups_40887	195.60 +- 94.65	2	0	2	0	0.02 +- 0.02	2	6 PF12697 (2/2) Alpha/beta hydrolase family PF02897 (2/2) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (2/2) Prolyl oligopeptidase family PF00313 (2/2) 'Cold-shock' DNA-binding domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_34827	96.37 +- 5.37	2	0	0	0	0.03 +- 0.04	2	4 PF13480 (2/2) Acetyltransferase (GNAT) domain PF02156 (2/2) Glycosyl hydrolase family 26 PF01522 (2/2) Polysaccharide deacetylase PF00535 (2/2) Glycosyl transferase family 2
precursor_jaccard_groups_36680	121.07 +- 15.52	2	0	0	0	0.03 +- 0.05	2	8 TIGR01297 (2/2) cation diffusion facilitator family transporter PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family PF01695 (2/2) IstB-like ATP binding protein PF01545 (2/2) Cation efflux family PF00665 (2/2) Integrase core domain PF00501 (2/2) AMP-binding enzyme PF00221 (2/2) Aromatic amino acid lyase
precursor_jaccard_groups_10178	277.22 +- 74.60	2	0	0	0	0.08 +- 0.08	2	22 TIGR01733 (2/2) amino acid adenylation domain PF18029 (2/2) Glyoxalase-like domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08713 (2/2) DNA alkylation repair enzyme PF08659 (2/2) KR domain PF07690 (2/2) Major Facilitator Superfamily PF07478 (2/2) D-ala D-ala ligase C-terminus PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01820 (2/2) D-ala D-ala ligase N-terminus PF01494 (2/2) FAD binding domain PF00975 (2/2) Thioesterase domain PF00850 (2/2) Histone deacetylase domain PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00698 (2/2) Acyl transferase domain PF00551 (2/2) Formyl transferase PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00355 (2/2) Rieske [2Fe-2S] domain PF00155 (2/2) Aminotransferase class I and II PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_10170	153.06 +- 34.46	4	0	4	0	0.06 +- 0.13	4	25 TIGR01762 (4/4) chlorinating enzyme TIGR01733 (4/4) amino acid adenylation domain TIGR01509 (4/4) HAD hydrolase, family IA, variant 3 TIGR01444 (4/4) methyltransferase, FkbM family TIGR00843 (4/4) benzoate transporter PF16990 (4/4) Carbohydrate binding module (family 35) PF13560 (4/4) Helix-turn-helix domain PF13535 (4/4) ATP-grasp domain PF13454 (4/4) FAD-NAD(P)-binding PF13419 (4/4) Haloacid dehalogenase-like hydrolase PF13193 (4/4) AMP-binding enzyme C-terminal domain PF07691 (4/4) PA14 domain PF06439 (4/4) Domain of Unknown Function (DUF1080) PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH) PF05050 (4/4) Methyltransferase FkbM domain PF04149 (4/4) Domain of unknown function (DUF397) PF03594 (4/4) Benzoate membrane transport protein PF02771 (4/4) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (4/4) Acyl-CoA dehydrogenase, middle domain PF01116 (4/4) Fructose-bisphosphate aldolase class-II PF00975 (4/4) Thioesterase domain PF00892 (4/4) EamA-like transporter family PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00441 (4/4) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_10172	618.09 +- 123.82	5	0	5	5	0.01 +- 0.02	5	15 TIGR04539 (5/5) tRNA-dependent cyclodipeptide synthase PF17676 (5/5) LD-carboxypeptidase C-terminal domain PF16715 (5/5) Cyclodipeptide synthase PF13847 (5/5) Methyltransferase domain PF13576 (5/5) Pentapeptide repeats (9 copies) PF13535 (5/5) ATP-grasp domain PF07690 (5/5) Major Facilitator Superfamily PF04055 (5/5) Radical SAM superfamily PF02310 (5/5) B12 binding domain PF02016 (5/5) LD-carboxypeptidase N-terminal domain PF01636 (5/5) Phosphotransferase enzyme family PF00196 (5/5) Bacterial regulatory proteins, luxR family PF00155 (5/5) Aminotransferase class I and II PF00152 (5/5) tRNA synthetases class II (D, K and N) PF00067 (5/5) Cytochrome P450
precursor_jaccard_groups_38688	1632.40 +- 187.60	2	0	2	2	0.01 +- 0.00	2	13 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (2/2) SagB-type dehydrogenase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF13601 (2/2) Winged helix DNA-binding domain PF13191 (2/2) AAA ATPase domain PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3368	87.16 +- 4.60	2	0	2	2	0.09 +- 0.18	2	12 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF13649 (2/2) Methyltransferase domain PF05147 (2/2) Lanthionine synthetase C-like protein PF04738 (2/2) Lantibiotic dehydratase, N terminus PF01292 (2/2) Prokaryotic cytochrome b561 PF00296 (2/2) Luciferase-like monooxygenase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00188 (2/2) Cysteine-rich secretory protein family PF00174 (2/2) Oxidoreductase molybdopterin binding domain PF00072 (2/2) Response regulator receiver domain PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4194	48.47 +- 11.07	7	0	0	0	0.07 +- 0.10	7	5 PF03450 (7/7) CO dehydrogenase flavoprotein C-terminal domain PF02738 (7/7) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (7/7) [2Fe-2S] binding domain PF01315 (7/7) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (7/7) FAD binding domain in molybdopterin dehydrogenase
precursor_jaccard_groups_40812	226.50 +- 31.50	2	0	0	0	0.01 +- 0.00	2	3 PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_12889	179.53 +- 21.38	2	0	2	0	0.08 +- 0.15	2	12 PF13641 (2/2) Glycosyltransferase like family 2 PF10823 (2/2) Protein of unknown function (DUF2568) PF09335 (2/2) SNARE associated Golgi protein PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF01810 (2/2) LysE type translocator PF01547 (2/2) Bacterial extracellular solute-binding protein PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00925 (2/2) GTP cyclohydrolase II PF00583 (2/2) Acetyltransferase (GNAT) family PF00400 (2/2) WD domain, G-beta repeat PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_16101	609.27 +- 165.86	3	0	3	0	0.01 +- 0.00	3	11 TIGR01900 (3/3) succinyl-diaminopimelate desuccinylase PF14518 (3/3) Iron-containing redox enzyme PF13378 (3/3) Enolase C-terminal domain-like PF07690 (3/3) Major Facilitator Superfamily PF02746 (3/3) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (3/3) Peptidase family M20/M25/M40 PF01063 (3/3) Amino-transferase class IV PF00682 (3/3) HMGL-like TIGR00035 (2/3) aspartate racemase PF01177 (2/3) Asp/Glu/Hydantoin racemase
precursor_jaccard_groups_2230	61.10 +- 12.21	3	0	1	0	0.05 +- 0.02	3	3 PF01292 (3/3) Prokaryotic cytochrome b561 PF00174 (3/3) Oxidoreductase molybdopterin binding domain PF07519 (2/3) Tannase and feruloyl esterase
precursor_jaccard_groups_1111	544.45 +- 297.46	29	0	0	0	0.02 +- 0.02	29	7 PF17914 (29/29) HopA1 effector protein family PF05193 (29/29) Peptidase M16 inactive domain PF02441 (29/29) Flavoprotein PF00675 (29/29) Insulinase (Peptidase family M16) PF13649 (28/29) Methyltransferase domain PF00296 (24/29) Luciferase-like monooxygenase PF00005 (22/29) ABC transporter
precursor_jaccard_groups_19369	1018.46 +- 114.56	3	0	0	3	0.01 +- 0.00	3	9 PF13661 (3/3) 2OG-Fe(II) oxygenase superfamily PF13640 (3/3) 2OG-Fe(II) oxygenase superfamily PF07690 (3/3) Major Facilitator Superfamily PF05193 (3/3) Peptidase M16 inactive domain PF04055 (3/3) Radical SAM superfamily PF00899 (3/3) ThiF family PF00675 (3/3) Insulinase (Peptidase family M16) PF00496 (3/3) Bacterial extracellular solute-binding proteins, family 5 Middle PF02310 (2/3) B12 binding domain
precursor_jaccard_groups_4810	2158.41 +- 761.00	8	0	1	0	0.01 +- 0.01	8	12 PF13560 (8/8) Helix-turn-helix domain PF13393 (8/8) Histidyl-tRNA synthetase PF05193 (8/8) Peptidase M16 inactive domain PF03721 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02585 (8/8) GlcNAc-PI de-N-acetylase PF01370 (8/8) NAD dependent epimerase/dehydratase family PF01061 (8/8) ABC-2 type transporter PF00984 (8/8) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00675 (8/8) Insulinase (Peptidase family M16) PF00005 (8/8) ABC transporter PF17874 (7/8) MalT-like TPR region
precursor_jaccard_groups_44133	182.05 +- 34.62	2	0	0	0	0.02 +- 0.02	2	6 TIGR03619 (2/2) probable F420-dependent oxidoreductase, Rv2161c family PF17148 (2/2) Domain of unknown function (DUF5117) PF16313 (2/2) Met-zincin PF07702 (2/2) UTRA domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_33095	69.96 +- 24.43	2	0	0	2	0.05 +- 0.09	2	11 TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family TIGR04268 (2/2) FXSXX-COOH protein TIGR04267 (2/2) HEXXH motif domain PF13676 (2/2) TIR domain PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF12680 (2/2) SnoaL-like domain PF04055 (2/2) Radical SAM superfamily PF01361 (2/2) Tautomerase enzyme PF00931 (2/2) NB-ARC domain
precursor_jaccard_groups_29992	705.83 +- 204.17	2	0	0	0	0.01 +- 0.01	2	7 PF18556 (2/2) Bacterial Tetracyclin repressor, C-terminal domain PF17754 (2/2) MftR C-terminal domain PF13460 (2/2) NAD(P)H-binding PF04075 (2/2) F420H(2)-dependent quinone reductase PF01418 (2/2) Helix-turn-helix domain, rpiR family PF01380 (2/2) SIS domain PF00440 (2/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_3064	117.96 +- 49.34	4	0	0	0	0.03 +- 0.02	4	6 PF14759 (4/4) Reductase C-terminal PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase PF14016 (3/4) Protein of unknown function (DUF4232) PF13370 (3/4) 4Fe-4S single cluster domain of Ferredoxin I PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_15901	365.31 +- 284.69	2	0	0	0	0.03 +- 0.05	2	3 PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF00246 (2/2) Zinc carboxypeptidase
precursor_jaccard_groups_26167	516.00 +- 258.00	2	0	0	0	0.02 +- 0.03	2	3 PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_340	1775.87 +- 1261.12	4	0	3	4	0.04 +- 0.14	4	8 PF13649 (4/4) Methyltransferase domain PF12730 (4/4) ABC-2 family transporter protein PF00465 (4/4) Iron-containing alcohol dehydrogenase PF00296 (4/4) Luciferase-like monooxygenase PF00202 (4/4) Aminotransferase class-III PF00069 (4/4) Protein kinase domain PF00005 (4/4) ABC transporter PF05147 (3/4) Lanthionine synthetase C-like protein
precursor_jaccard_groups_343	285.64 +- 129.72	9	0	9	0	0.07 +- 0.14	9	16 TIGR03945 (9/9) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (9/9) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01733 (9/9) amino acid adenylation domain TIGR01720 (9/9) non-ribosomal peptide synthase domain TIGR01720 TIGR01188 (9/9) daunorubicin resistance ABC transporter, ATP-binding protein PF13193 (9/9) AMP-binding enzyme C-terminal domain PF03621 (9/9) MbtH-like protein PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family PF01061 (9/9) ABC-2 type transporter PF00975 (9/9) Thioesterase domain PF00668 (9/9) Condensation domain PF00550 (9/9) Phosphopantetheine attachment site PF00501 (9/9) AMP-binding enzyme PF00291 (9/9) Pyridoxal-phosphate dependent enzyme PF00005 (9/9) ABC transporter PF13732 (7/9) Domain of unknown function (DUF4162)
precursor_jaccard_groups_20740	445.71 +- 74.29	2	0	2	0	0.01 +- 0.00	2	8 PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02780 (2/2) Transketolase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF00676 (2/2) Dehydrogenase E1 component PF00550 (2/2) Phosphopantetheine attachment site PF00364 (2/2) Biotin-requiring enzyme PF00198 (2/2) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
precursor_jaccard_groups_9015	394.50 +- 74.31	5	0	0	0	0.02 +- 0.03	5	6 PF08386 (5/5) TAP-like protein PF07690 (5/5) Major Facilitator Superfamily PF01979 (5/5) Amidohydrolase family PF00561 (5/5) alpha/beta hydrolase fold PF00326 (5/5) Prolyl oligopeptidase family PF13649 (3/5) Methyltransferase domain
precursor_jaccard_groups_7544	187.56 +- 79.93	4	0	0	0	0.03 +- 0.04	4	5 PF06628 (4/4) Catalase-related immune-responsive PF01475 (4/4) Ferric uptake regulator family PF00248 (4/4) Aldo/keto reductase family PF00199 (4/4) Catalase PF08240 (2/4) Alcohol dehydrogenase GroES-like domain
precursor_jaccard_groups_21	40.24 +- 11.75	3	0	0	0	0.08 +- 0.17	3	3 TIGR03296 (3/3) M6 family metalloprotease domain PF09339 (3/3) IclR helix-turn-helix domain PF03777 (3/3) ChpA-C
precursor_jaccard_groups_2928	239.85 +- 35.57	9	0	0	0	0.01 +- 0.00	9	3 PF13545 (9/9) Crp-like helix-turn-helix domain PF07228 (9/9) Stage II sporulation protein E (SpoIIE) PF00027 (9/9) Cyclic nucleotide-binding domain
precursor_jaccard_groups_29694	45.39 +- 2.39	2	0	2	0	0.04 +- 0.04	2	7 PF12697 (2/2) Alpha/beta hydrolase family PF07063 (2/2) Domain of unknown function (DUF1338) PF01266 (2/2) FAD dependent oxidoreductase PF00171 (2/2) Aldehyde dehydrogenase family PF17874 (1/2) MalT-like TPR region PF13560 (1/2) Helix-turn-helix domain PF13432 (1/2) Tetratricopeptide repeat
precursor_jaccard_groups_35370	52.32 +- 21.97	2	0	2	0	0.05 +- 0.02	2	2 PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
precursor_jaccard_groups_7068	800.06 +- 256.65	6	0	5	0	0.01 +- 0.01	6	11 PF17914 (6/6) HopA1 effector protein family PF05193 (6/6) Peptidase M16 inactive domain PF01636 (6/6) Phosphotransferase enzyme family PF00675 (6/6) Insulinase (Peptidase family M16) PF13649 (5/6) Methyltransferase domain PF13546 (5/6) DDE superfamily endonuclease PF02441 (5/6) Flavoprotein PF00005 (5/6) ABC transporter TIGR00414 (3/6) serine--tRNA ligase PF02403 (3/6) Seryl-tRNA synthetase N-terminal domain PF00587 (3/6) tRNA synthetase class II core domain (G, H, P, S and T)
precursor_jaccard_groups_16192	325.00 +- 239.00	3	0	0	0	0.03 +- 0.08	3	3 PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01145 (3/3) SPFH domain / Band 7 family PF00877 (3/3) NlpC/P60 family
precursor_jaccard_groups_240	27.25 +- 2.74	9	0	3	0	0.07 +- 0.09	9	6 PF13244 (9/9) Domain of unknown function (DUF4040) PF12840 (9/9) Helix-turn-helix domain PF04066 (9/9) Multiple resistance and pH regulation protein F (MrpF / PhaF) PF04039 (9/9) Domain related to MnhB subunit of Na+/H+ antiporter PF00420 (9/9) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PF00361 (9/9) Proton-conducting membrane transporter
precursor_jaccard_groups_9715	148.40 +- 67.91	5	0	0	0	0.02 +- 0.02	5	3 PF08386 (5/5) TAP-like protein PF07228 (5/5) Stage II sporulation protein E (SpoIIE) PF00561 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_480	423.60 +- 111.96	20	0	4	0	0.05 +- 0.16	20	14 TIGR01850 (20/20) N-acetyl-gamma-glutamyl-phosphate reductase PF08443 (20/20) RimK-like ATP-grasp domain PF02779 (20/20) Transketolase, pyrimidine binding domain PF01118 (20/20) Semialdehyde dehydrogenase, NAD binding domain PF00456 (20/20) Transketolase, thiamine diphosphate binding domain TIGR01902 (19/20) N-acetyl-ornithine/N-acetyl-lysine deacetylase PF01546 (19/20) Peptidase family M20/M25/M40 PF01041 (19/20) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (19/20) Amino acid kinase family TIGR00768 (16/20) alpha-L-glutamate ligase, RimK family PF18603 (15/20) L-amino acid ligase C-terminal domain 2 PF18130 (15/20) ATP-grasp N-terminal domain PF13535 (15/20) ATP-grasp domain PF07690 (15/20) Major Facilitator Superfamily
precursor_jaccard_groups_13410	1556.00 +- 516.03	4	0	0	0	0.01 +- 0.00	4	7 PF08386 (4/4) TAP-like protein PF07702 (4/4) UTRA domain PF01380 (4/4) SIS domain PF00561 (4/4) alpha/beta hydrolase fold PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00294 (4/4) pfkB family carbohydrate kinase PF00196 (4/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_28573	647.50 +- 2.50	2	0	0	0	0.01 +- 0.00	2	10 TIGR03923 (2/2) type VII secretion protein EccE TIGR03921 (2/2) type VII secretion-associated serine protease mycosin TIGR02937 (2/2) RNA polymerase sigma factor, sigma-70 family PF14226 (2/2) non-haem dioxygenase in morphine synthesis N-terminal PF11203 (2/2) Putative type VII ESX secretion system translocon, EccE PF04545 (2/2) Sigma-70, region 4 PF04542 (2/2) Sigma-70 region 2 PF03640 (2/2) Secreted repeat of unknown function PF03171 (2/2) 2OG-Fe(II) oxygenase superfamily PF00082 (2/2) Subtilase family
precursor_jaccard_groups_15301	344.00 +- 86.00	2	0	0	0	0.01 +- 0.01	2	7 TIGR03696 (2/2) RHS repeat-associated core domain TIGR01643 (2/2) YD repeat (two copies) PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF13424 (2/2) Tetratricopeptide repeat PF09206 (2/2) Alpha-L-arabinofuranosidase B, catalytic PF05593 (2/2) RHS Repeat PF00156 (2/2) Phosphoribosyl transferase domain
precursor_jaccard_groups_2331	229.23 +- 30.77	2	0	1	0	0.01 +- 0.01	2	7 PF03412 (2/2) Peptidase C39 family PF00664 (2/2) ABC transporter transmembrane region PF00535 (2/2) Glycosyl transferase family 2 PF00005 (2/2) ABC transporter PF13592 (1/2) Winged helix-turn helix PF13384 (1/2) Homeodomain-like domain PF13358 (1/2) DDE superfamily endonuclease
precursor_jaccard_groups_9155	1991.35 +- 896.21	5	0	5	0	0.02 +- 0.10	5	34 TIGR01263 (5/5) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (5/5) diaminopimelate epimerase PF18603 (5/5) L-amino acid ligase C-terminal domain 2 PF18130 (5/5) ATP-grasp N-terminal domain PF14518 (5/5) Iron-containing redox enzyme PF14226 (5/5) non-haem dioxygenase in morphine synthesis N-terminal PF13535 (5/5) ATP-grasp domain PF13458 (5/5) Periplasmic binding protein PF12399 (5/5) Branched-chain amino acid ATP-binding cassette transporter PF10014 (5/5) 2OG-Fe dioxygenase PF08241 (5/5) Methyltransferase domain PF07859 (5/5) alpha/beta hydrolase fold PF07690 (5/5) Major Facilitator Superfamily PF05721 (5/5) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (5/5) Aminopeptidase P, N-terminal domain PF04879 (5/5) Molybdopterin oxidoreductase Fe4S4 domain PF03328 (5/5) HpcH/HpaI aldolase/citrate lyase family PF03171 (5/5) 2OG-Fe(II) oxygenase superfamily PF02653 (5/5) Branched-chain amino acid transport system / permease component PF02423 (5/5) Ornithine cyclodeaminase/mu-crystallin family PF02153 (5/5) Prephenate dehydrogenase PF01678 (5/5) Diaminopimelate epimerase PF01575 (5/5) MaoC like domain PF01568 (5/5) Molydopterin dinucleotide binding domain PF01425 (5/5) Amidase PF01070 (5/5) FMN-dependent dehydrogenase PF00903 (5/5) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (5/5) EamA-like transporter family PF00682 (5/5) HMGL-like PF00557 (5/5) Metallopeptidase family M24 PF00384 (5/5) Molybdopterin oxidoreductase PF00248 (5/5) Aldo/keto reductase family PF00155 (5/5) Aminotransferase class I and II PF00005 (5/5) ABC transporter
precursor_jaccard_groups_41971	390.00 +- 0.00	2	0	1	0	0.01 +- 0.00	2	4 PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01613 (2/2) Flavin reductase like domain PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00296 (2/2) Luciferase-like monooxygenase
precursor_jaccard_groups_45631	216.00 +- 44.00	2	0	0	0	0.01 +- 0.00	2	3 PF13229 (2/2) Right handed beta helix region PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02018 (2/2) Carbohydrate binding domain
precursor_jaccard_groups_1529	4393.65 +- 2025.62	13	0	13	13	0.02 +- 0.07	13	8 TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (13/13) Nitroreductase family PF00005 (13/13) ABC transporter PF05402 (10/13) Coenzyme PQQ synthesis protein D (PqqD) PF12698 (7/13) ABC-2 family transporter protein
precursor_jaccard_groups_11329	63.45 +- 1.05	2	0	0	0	0.06 +- 0.06	2	5 PF08220 (2/2) DeoR-like helix-turn-helix domain PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF00455 (2/2) DeoR C terminal sensor domain PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_38131	194.50 +- 52.12	2	0	0	0	0.07 +- 0.08	2	15 TIGR00976 (2/2) hydrolase CocE/NonD family protein TIGR00026 (2/2) deazaflavin-dependent oxidoreductase, nitroreductase family PF13977 (2/2) BetI-type transcriptional repressor, C-terminal PF12911 (2/2) N-terminal TM domain of oligopeptide transport permease C PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07690 (2/2) Major Facilitator Superfamily PF04075 (2/2) F420H(2)-dependent quinone reductase PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00005 (2/2) ABC transporter TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF06983 (1/2) 3-demethylubiquinone-9 3-methyltransferase
precursor_jaccard_groups_22415	778.00 +- 2.83	3	0	0	3	0.01 +- 0.00	3	8 TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (3/3) SagB-type dehydrogenase domain PF16058 (3/3) Mucin-like PF07690 (3/3) Major Facilitator Superfamily PF03972 (3/3) MmgE/PrpD family PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (3/3) Nitroreductase family PF00675 (3/3) Insulinase (Peptidase family M16)
precursor_jaccard_groups_8277	59.27 +- 22.81	4	0	4	0	0.04 +- 0.07	4	6 PF13231 (4/4) Dolichyl-phosphate-mannose-protein mannosyltransferase PF08241 (4/4) Methyltransferase domain PF04205 (4/4) FMN-binding domain PF02424 (4/4) ApbE family PF01794 (4/4) Ferric reductase like transmembrane component PF00175 (4/4) Oxidoreductase NAD-binding domain
precursor_jaccard_groups_29303	93.44 +- 9.76	2	0	0	0	0.04 +- 0.07	2	5 PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF03575 (2/2) Peptidase family S51 PF02852 (2/2) Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_45654	129.50 +- 0.50	2	0	1	0	0.02 +- 0.00	2	5 PF12708 (2/2) Pectate lyase superfamily protein PF10633 (2/2) NPCBM-associated, NEW3 domain of alpha-galactosidase PF01120 (2/2) Alpha-L-fucosidase PF00754 (2/2) F5/8 type C domain PF00295 (2/2) Glycosyl hydrolases family 28
precursor_jaccard_groups_4962	94.90 +- 28.28	4	0	0	0	0.04 +- 0.02	4	6 PF12697 (4/4) Alpha/beta hydrolase family PF07729 (4/4) FCD domain PF06684 (4/4) Amino acid synthesis PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00296 (4/4) Luciferase-like monooxygenase PF00171 (4/4) Aldehyde dehydrogenase family
precursor_jaccard_groups_3243	280.13 +- 235.87	2	0	0	2	0.05 +- 0.16	2	7 PF14518 (2/2) Iron-containing redox enzyme PF12704 (2/2) MacB-like periplasmic core domain PF04055 (2/2) Radical SAM superfamily PF03704 (2/2) Bacterial transcriptional activator domain PF02687 (2/2) FtsX-like permease family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_jaccard_groups_14805	27.10 +- 6.92	3	0	0	0	0.08 +- 0.07	3	3 TIGR01249 (3/3) prolyl aminopeptidase PF07470 (3/3) Glycosyl Hydrolase Family 88 PF00561 (3/3) alpha/beta hydrolase fold
precursor_jaccard_groups_3576	122.11 +- 96.49	3	0	0	0	0.03 +- 0.04	3	5 TIGR01840 (3/3) esterase, PHB depolymerase family TIGR00666 (3/3) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase PF14016 (3/3) Protein of unknown function (DUF4232) PF10503 (3/3) Esterase PHB depolymerase PF02113 (3/3) D-Ala-D-Ala carboxypeptidase 3 (S13) family
precursor_jaccard_groups_7966	864.29 +- 155.78	3	0	3	3	0.01 +- 0.02	3	9 TIGR04085 (3/3) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (3/3) Iron-sulfur cluster-binding domain PF08241 (3/3) Methyltransferase domain PF07690 (3/3) Major Facilitator Superfamily PF04055 (3/3) Radical SAM superfamily PF01980 (3/3) tRNA-methyltransferase O PF01494 (3/3) FAD binding domain PF17920 (2/3) Tetracyclin repressor-like, C-terminal domain PF00440 (2/3) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_40595	209.46 +- 92.46	2	0	0	0	0.08 +- 0.08	2	11 TIGR01234 (2/2) ribulokinase PF18029 (2/2) Glyoxalase-like domain PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF11762 (2/2) L-arabinose isomerase C-terminal domain PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain PF02610 (2/2) L-arabinose isomerase PF01547 (2/2) Bacterial extracellular solute-binding protein PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain
precursor_jaccard_groups_10347	447.82 +- 139.46	3	0	1	0	0.06 +- 0.21	3	11 PF17914 (3/3) HopA1 effector protein family PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF02441 (3/3) Flavoprotein PF01636 (3/3) Phosphotransferase enzyme family PF00326 (3/3) Prolyl oligopeptidase family PF00296 (3/3) Luciferase-like monooxygenase PF07730 (2/3) Histidine kinase PF01061 (2/3) ABC-2 type transporter PF00196 (2/3) Bacterial regulatory proteins, luxR family PF00072 (2/3) Response regulator receiver domain PF00005 (2/3) ABC transporter
precursor_jaccard_groups_44899	216.17 +- 107.83	2	0	0	0	0.04 +- 0.05	2	9 TIGR02122 (2/2) TRAP transporter solute receptor, TAXI family TIGR01979 (2/2) cysteine desulfurase, SufS family PF16868 (2/2) NMT1-like family PF05977 (2/2) Transmembrane secretion effector PF04185 (2/2) Phosphoesterase family PF00266 (2/2) Aminotransferase class-V PF00027 (2/2) Cyclic nucleotide-binding domain TIGR01167 (1/2) LPXTG cell wall anchor domain PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_2207	839.58 +- 460.42	4	2	2	4	0.02 +- 0.02	2	13 TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain TIGR03731 (4/4) lantibiotic, gallidermin/nisin family PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term PF05147 (4/4) Lanthionine synthetase C-like protein PF04738 (4/4) Lantibiotic dehydratase, N terminus PF01061 (4/4) ABC-2 type transporter PF00005 (4/4) ABC transporter PF02052 (3/4) Gallidermin TIGR02937 (2/4) RNA polymerase sigma factor, sigma-70 family PF10709 (2/4) Protein of unknown function (DUF2511) PF08281 (2/4) Sigma-70, region 4 PF04542 (2/4) Sigma-70 region 2 PF04072 (2/4) Leucine carboxyl methyltransferase
precursor_jaccard_groups_10572	1767.52 +- 216.09	3	0	1	3	0.01 +- 0.02	3	10 TIGR00702 (3/3) YcaO-type kinase domain PF13302 (3/3) Acetyltransferase (GNAT) domain PF08007 (3/3) Cupin superfamily protein PF07812 (3/3) TfuA-like protein PF07690 (3/3) Major Facilitator Superfamily PF05193 (3/3) Peptidase M16 inactive domain PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02522 (3/3) Aminoglycoside 3-N-acetyltransferase PF00675 (3/3) Insulinase (Peptidase family M16) PF00326 (3/3) Prolyl oligopeptidase family
precursor_jaccard_groups_8284	116.33 +- 25.07	6	0	6	6	0.04 +- 0.04	6	4 TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase PF16715 (6/6) Cyclodipeptide synthase PF00881 (6/6) Nitroreductase family PF00089 (6/6) Trypsin
precursor_jaccard_groups_18924	419.05 +- 139.95	3	0	0	0	0.01 +- 0.00	3	9 PF17853 (3/3) GGDEF-like domain PF13556 (3/3) PucR C-terminal helix-turn-helix domain PF12450 (3/3) von Willebrand factor PF12034 (3/3) Domain of unknown function (DUF3520) PF08592 (3/3) Domain of unknown function (DUF1772) PF03704 (3/3) Bacterial transcriptional activator domain PF00486 (3/3) Transcriptional regulatory protein, C terminal PF00092 (3/3) von Willebrand factor type A domain PF01590 (2/3) GAF domain
precursor_jaccard_groups_5444	780.00 +- 260.00	6	0	0	6	0.01 +- 0.00	6	4 PF07690 (6/6) Major Facilitator Superfamily PF04055 (6/6) Radical SAM superfamily PF02441 (6/6) Flavoprotein PF02310 (3/6) B12 binding domain
precursor_jaccard_groups_5448	206.28 +- 77.96	4	0	0	0	0.09 +- 0.09	4	17 TIGR01409 (4/4) Tat (twin-arginine translocation) pathway signal sequence PF17801 (4/4) Alpha galactosidase C-terminal beta sandwich domain PF16875 (4/4) Glycosyl hydrolase family 36 N-terminal domain PF16874 (4/4) Glycosyl hydrolase family 36 C-terminal domain PF16499 (4/4) Alpha galactosidase A PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13378 (4/4) Enolase C-terminal domain-like PF08450 (4/4) SMP-30/Gluconolactonase/LRE-like region PF07729 (4/4) FCD domain PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (4/4) Melibiase PF01547 (4/4) Bacterial extracellular solute-binding protein PF01081 (4/4) KDPG and KHG aldolase PF00583 (4/4) Acetyltransferase (GNAT) family PF00528 (4/4) Binding-protein-dependent transport system inner membrane component PF00392 (4/4) Bacterial regulatory proteins, gntR family PF00294 (4/4) pfkB family carbohydrate kinase
precursor_jaccard_groups_5722	32.06 +- 9.93	8	0	0	0	0.07 +- 0.05	8	4 PF17074 (8/8) Darcynin, domain of unknown function PF08021 (8/8) Siderophore-interacting FAD-binding domain PF04954 (8/8) Siderophore-interacting protein PF03446 (8/8) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_570	247.62 +- 143.54	6	0	6	6	0.02 +- 0.03	6	4 TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF05147 (6/6) Lanthionine synthetase C-like protein PF04738 (5/6) Lantibiotic dehydratase, N terminus
precursor_jaccard_groups_37299	1068.75 +- 101.25	2	0	0	0	0.01 +- 0.00	2	5 PF13416 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF00962 (2/2) Adenosine/AMP deaminase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_jaccard_groups_30800	146.32 +- 79.43	2	0	0	2	0.04 +- 0.06	2	7 TIGR04187 (2/2) ATP-grasp ribosomal peptide maturase, SAV_5884 family TIGR04186 (2/2) putative ATP-grasp target RiPP TIGR03668 (2/2) PPOX class probable F420-dependent enzyme, Rv0121 family PF07702 (2/2) UTRA domain PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_4143	91.00 +- 39.00	2	0	0	0	0.03 +- 0.02	2	2 PF03130 (2/2) PBS lyase HEAT-like repeat PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
precursor_jaccard_groups_4145	444.94 +- 356.18	4	0	0	0	0.03 +- 0.04	4	6 PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF03992 (4/4) Antibiotic biosynthesis monooxygenase PF00664 (4/4) ABC transporter transmembrane region PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00248 (4/4) Aldo/keto reductase family PF00005 (4/4) ABC transporter
precursor_jaccard_groups_29710	291.55 +- 224.45	2	0	0	0	0.03 +- 0.06	2	1 PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase
precursor_jaccard_groups_30662	582.00 +- 192.00	2	0	0	0	0.01 +- 0.01	2	10 PF13191 (2/2) AAA ATPase domain PF07504 (2/2) Fungalysin/Thermolysin Propeptide Motif PF05345 (2/2) Putative Ig domain PF02868 (2/2) Thermolysin metallopeptidase, alpha-helical domain PF02225 (2/2) PA domain PF01638 (2/2) HxlR-like helix-turn-helix PF01483 (2/2) Proprotein convertase P-domain PF01447 (2/2) Thermolysin metallopeptidase, catalytic domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00082 (2/2) Subtilase family
precursor_jaccard_groups_26287	105.74 +- 24.26	2	0	0	0	0.03 +- 0.03	2	3 PF07690 (2/2) Major Facilitator Superfamily PF01255 (2/2) Putative undecaprenyl diphosphate synthase PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_jaccard_groups_44459	344.00 +- 0.00	2	0	0	0	0.03 +- 0.02	2	5 PF07690 (2/2) Major Facilitator Superfamily PF06772 (2/2) Bacterial low temperature requirement A protein (LtrA) PF00561 (2/2) alpha/beta hydrolase fold PF00296 (2/2) Luciferase-like monooxygenase PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_888	622.49 +- 466.04	22	0	22	0	0.07 +- 0.11	22	27 TIGR01733 (22/22) amino acid adenylation domain TIGR01525 (22/22) heavy metal translocating P-type ATPase PF13193 (22/22) AMP-binding enzyme C-terminal domain PF10862 (22/22) FcoT-like thioesterase domain PF08545 (22/22) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (22/22) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (22/22) Male sterility protein PF07690 (22/22) Major Facilitator Superfamily PF05118 (22/22) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (22/22) Copper chaperone PCu(A)C PF02668 (22/22) Taurine catabolism dioxygenase TauD, TfdA family PF00702 (22/22) haloacid dehalogenase-like hydrolase PF00668 (22/22) Condensation domain PF00550 (22/22) Phosphopantetheine attachment site PF00501 (22/22) AMP-binding enzyme PF00403 (22/22) Heavy-metal-associated domain PF00122 (22/22) E1-E2 ATPase TIGR01746 (21/22) thioester reductase domain TIGR00747 (21/22) 3-oxoacyl-[acyl-carrier-protein] synthase III PF01497 (20/22) Periplasmic binding protein PF01032 (20/22) FecCD transport family PF00005 (20/22) ABC transporter PF01965 (19/22) DJ-1/PfpI family TIGR02937 (11/22) RNA polymerase sigma factor, sigma-70 family PF08281 (11/22) Sigma-70, region 4 PF04542 (11/22) Sigma-70 region 2 PF03929 (11/22) PepSY-associated TM region
precursor_jaccard_groups_20631	516.00 +- 0.00	2	0	2	2	0.01 +- 0.00	2	7 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03558 (2/2) luciferase family oxidoreductase, group 1 PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF05147 (2/2) Lanthionine synthetase C-like protein PF04738 (2/2) Lantibiotic dehydratase, N terminus PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7757	782.11 +- 340.79	6	0	0	0	0.01 +- 0.01	6	6 TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain TIGR01420 (6/6) twitching motility protein PF07963 (6/6) Prokaryotic N-terminal methylation motif PF05157 (6/6) Type II secretion system (T2SS), protein E, N-terminal domain PF00482 (6/6) Type II secretion system (T2SS), protein F PF00437 (6/6) Type II/IV secretion system protein
precursor_jaccard_groups_31899	129.86 +- 93.00	2	0	0	0	0.05 +- 0.10	2	3 PF03483 (2/2) B3/4 domain PF01810 (2/2) LysE type translocator PF00300 (2/2) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_7758	137.60 +- 68.80	2	0	0	0	0.06 +- 0.05	2	8 PF14864 (2/2) Alkyl sulfatase C-terminal PF14863 (2/2) Alkyl sulfatase dimerisation PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF00753 (2/2) Metallo-beta-lactamase superfamily PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
precursor_jaccard_groups_28707	516.88 +- 343.12	2	0	2	0	0.04 +- 0.11	2	19 TIGR01733 (2/2) amino acid adenylation domain TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720 TIGR00171 (2/2) 3-isopropylmalate dehydratase, small subunit TIGR00170 (2/2) 3-isopropylmalate dehydratase, large subunit TIGR00169 (2/2) 3-isopropylmalate dehydrogenase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF11806 (2/2) Domain of unknown function (DUF3327) PF08242 (2/2) Methyltransferase domain PF03621 (2/2) MbtH-like protein PF00756 (2/2) Putative esterase PF00694 (2/2) Aconitase C-terminal domain PF00682 (2/2) HMGL-like PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00330 (2/2) Aconitase family (aconitate hydratase) PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_477	128.69 +- 4.34	2	0	0	0	0.09 +- 0.07	2	14 PF14310 (2/2) Fibronectin type III-like domain PF13802 (2/2) Galactose mutarotase-like PF13377 (2/2) Periplasmic binding protein-like domain PF03422 (2/2) Carbohydrate binding module (family 6) PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain PF01055 (2/2) Glycosyl hydrolases family 31 PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family PF13416 (1/2) Bacterial extracellular solute-binding protein PF07690 (1/2) Major Facilitator Superfamily PF04075 (1/2) F420H(2)-dependent quinone reductase PF01547 (1/2) Bacterial extracellular solute-binding protein
precursor_jaccard_groups_6694	806.75 +- 193.00	2	0	1	2	0.05 +- 0.17	2	26 TIGR04364 (2/2) methyltransferase, FxLD system TIGR04363 (2/2) FxLD family lantipeptide TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF13581 (2/2) Histidine kinase-like ATPase domain PF05331 (2/2) Protein of unknown function (DUF742) PF05147 (2/2) Lanthionine synthetase C-like protein PF04851 (2/2) Type III restriction enzyme, res subunit PF04738 (2/2) Lantibiotic dehydratase, N terminus PF04672 (2/2) S-adenosyl methyltransferase PF03457 (2/2) Helicase associated domain PF03259 (2/2) Roadblock/LC7 domain PF03029 (2/2) Conserved hypothetical ATP binding protein PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF01636 (2/2) Phosphotransferase enzyme family PF01590 (2/2) GAF domain PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00293 (2/2) NUDIX domain PF00271 (2/2) Helicase conserved C-terminal domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF13649 (1/2) Methyltransferase domain PF08241 (1/2) Methyltransferase domain PF00872 (1/2) Transposase, Mutator family
precursor_jaccard_groups_37668	328.15 +- 104.38	2	0	2	0	0.07 +- 0.16	2	15 TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF12146 (2/2) Serine aminopeptidase, S33 PF07977 (2/2) FabA-like domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02786 (2/2) Carbamoyl-phosphate synthase L chain, ATP binding domain PF01323 (2/2) DSBA-like thioredoxin domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF12697 (1/2) Alpha/beta hydrolase family PF02785 (1/2) Biotin carboxylase C-terminal domain PF00364 (1/2) Biotin-requiring enzyme PF00289 (1/2) Biotin carboxylase, N-terminal domain
precursor_jaccard_groups_22685	738.11 +- 238.15	3	0	3	0	0.01 +- 0.01	3	13 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF13535 (3/3) ATP-grasp domain PF13394 (3/3) 4Fe-4S single cluster domain PF07690 (3/3) Major Facilitator Superfamily PF06508 (3/3) Queuosine biosynthesis protein QueC PF06368 (3/3) Methylaspartate mutase E chain (MutE) PF02310 (3/3) B12 binding domain PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase PF01227 (3/3) GTP cyclohydrolase I PF00668 (3/3) Condensation domain PF00501 (3/3) AMP-binding enzyme PF00487 (3/3) Fatty acid desaturase
precursor_jaccard_groups_37661	133.61 +- 63.96	2	0	2	0	0.09 +- 0.20	2	22 TIGR01746 (2/2) thioester reductase domain TIGR01733 (2/2) amino acid adenylation domain PF16864 (2/2) Dimerisation domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07993 (2/2) Male sterility protein PF04389 (2/2) Peptidase family M28 PF03621 (2/2) MbtH-like protein PF00891 (2/2) O-methyltransferase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF13847 (1/2) Methyltransferase domain PF13459 (1/2) 4Fe-4S single cluster domain PF08241 (1/2) Methyltransferase domain PF08031 (1/2) Berberine and berberine like PF07690 (1/2) Major Facilitator Superfamily PF07366 (1/2) SnoaL-like polyketide cyclase PF06821 (1/2) Serine hydrolase PF01565 (1/2) FAD binding domain PF01494 (1/2) FAD binding domain PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase PF00067 (1/2) Cytochrome P450
precursor_jaccard_groups_3570	414.92 +- 442.96	5	0	0	0	0.06 +- 0.12	5	7 PF13407 (5/5) Periplasmic binding protein domain PF13377 (5/5) Periplasmic binding protein-like domain PF02653 (5/5) Branched-chain amino acid transport system / permease component PF00356 (5/5) Bacterial regulatory proteins, lacI family PF00294 (5/5) pfkB family carbohydrate kinase PF00005 (5/5) ABC transporter PF05025 (4/5) RbsD / FucU transport protein family
precursor_jaccard_groups_208	41.61 +- 0.00	2	0	2	0	0.10 +- 0.09	2	4 PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I PF07690 (2/2) Major Facilitator Superfamily PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_21036	453.70 +- 99.16	2	0	0	0	0.03 +- 0.02	2	7 TIGR03296 (2/2) M6 family metalloprotease domain TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF00561 (2/2) alpha/beta hydrolase fold PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00005 (2/2) ABC transporter
precursor_jaccard_groups_6573	164.69 +- 103.36	7	0	0	0	0.05 +- 0.04	7	11 TIGR03217 (7/7) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (7/7) acetaldehyde dehydrogenase (acetylating) PF13621 (7/7) Cupin-like domain PF09290 (7/7) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF07836 (7/7) DmpG-like communication domain PF07690 (7/7) Major Facilitator Superfamily PF03328 (7/7) HpcH/HpaI aldolase/citrate lyase family PF02423 (7/7) Ornithine cyclodeaminase/mu-crystallin family PF01118 (7/7) Semialdehyde dehydrogenase, NAD binding domain PF00682 (7/7) HMGL-like PF00155 (7/7) Aminotransferase class I and II
precursor_jaccard_groups_1587	52.74 +- 14.93	6	0	0	0	0.06 +- 0.05	6	5 PF05331 (6/6) Protein of unknown function (DUF742) PF04149 (6/6) Domain of unknown function (DUF397) PF03259 (6/6) Roadblock/LC7 domain PF03029 (6/6) Conserved hypothetical ATP binding protein PF00067 (6/6) Cytochrome P450
precursor_jaccard_groups_44422	1548.00 +- 0.00	2	0	0	2	0.01 +- 0.00	2	17 TIGR01549 (2/2) HAD hydrolase, family IA, variant 1 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF13242 (2/2) HAD-hyrolase-like PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12833 (2/2) Helix-turn-helix domain PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF04055 (2/2) Radical SAM superfamily PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain PF02811 (2/2) PHP domain PF02310 (2/2) B12 binding domain PF01522 (2/2) Polysaccharide deacetylase PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF00535 (2/2) Glycosyl transferase family 2 PF00501 (2/2) AMP-binding enzyme PF00202 (2/2) Aminotransferase class-III
precursor_jaccard_groups_41940	347.93 +- 153.74	2	0	2	2	0.05 +- 0.08	2	10 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_jaccard_groups_37196	194.00 +- 64.00	2	0	0	0	0.01 +- 0.01	2	3 PF05901 (2/2) Excalibur calcium-binding domain PF01738 (2/2) Dienelactone hydrolase family PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_102	500.84 +- 250.71	5	0	5	5	0.02 +- 0.05	5	11 TIGR03897 (5/5) type 2 lantibiotic biosynthesis protein LanM PF13575 (5/5) Domain of unknown function (DUF4135) PF13191 (5/5) AAA ATPase domain PF05147 (5/5) Lanthionine synthetase C-like protein PF03704 (5/5) Bacterial transcriptional activator domain PF00931 (5/5) NB-ARC domain PF00486 (5/5) Transcriptional regulatory protein, C terminal PF00196 (5/5) Bacterial regulatory proteins, luxR family PF13185 (4/5) GAF domain PF08448 (4/5) PAS fold PF07228 (4/5) Stage II sporulation protein E (SpoIIE)
precursor_jaccard_groups_37762	53.39 +- 20.89	2	0	0	0	0.05 +- 0.04	2	5 PF13602 (2/2) Zinc-binding dehydrogenase PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF00106 (2/2) short chain dehydrogenase PF13564 (1/2) DoxX-like family PF00296 (1/2) Luciferase-like monooxygenase
precursor_jaccard_groups_1299	56.37 +- 16.27	3	0	0	0	0.08 +- 0.07	3	4 TIGR03860 (3/3) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF07690 (3/3) Major Facilitator Superfamily PF00296 (3/3) Luciferase-like monooxygenase PF00106 (3/3) short chain dehydrogenase
precursor_jaccard_groups_22033	760.47 +- 374.44	3	0	0	0	0.04 +- 0.12	3	26 TIGR03567 (3/3) FMN reductase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF16653 (3/3) Saccharopine dehydrogenase C-terminal domain PF14559 (3/3) Tetratricopeptide repeat PF13535 (3/3) ATP-grasp domain PF13434 (3/3) L-lysine 6-monooxygenase (NADPH-requiring) PF13432 (3/3) Tetratricopeptide repeat PF13424 (3/3) Tetratricopeptide repeat PF07690 (3/3) Major Facilitator Superfamily PF03358 (3/3) NADPH-dependent FMN reductase PF02897 (3/3) Prolyl oligopeptidase, N-terminal beta-propeller domain PF01613 (3/3) Flavin reductase like domain PF00326 (3/3) Prolyl oligopeptidase family PF00294 (3/3) pfkB family carbohydrate kinase TIGR02937 (2/3) RNA polymerase sigma factor, sigma-70 family PF09334 (2/3) tRNA synthetases class I (M) PF08281 (2/3) Sigma-70, region 4 PF07883 (2/3) Cupin domain PF04542 (2/3) Sigma-70 region 2 PF02826 (2/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02142 (2/3) MGS-like domain PF01808 (2/3) AICARFT/IMPCHase bienzyme PF00709 (2/3) Adenylosuccinate synthetase PF00355 (2/3) Rieske [2Fe-2S] domain PF00202 (2/3) Aminotransferase class-III
precursor_jaccard_groups_27906	149.12 +- 39.59	2	0	0	0	0.06 +- 0.02	2	7 PF16353 (2/2) Domain of unknown function(DUF4981) PF02929 (2/2) Beta galactosidase small chain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain PF01547 (2/2) Bacterial extracellular solute-binding protein PF01074 (2/2) Glycosyl hydrolases family 38 N-terminal domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
precursor_jaccard_groups_44055	1163.94 +- 693.66	2	0	0	0	0.02 +- 0.01	2	18 TIGR03561 (2/2) peroxiredoxin, Ohr subfamily PF13649 (2/2) Methyltransferase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF09339 (2/2) IclR helix-turn-helix domain PF09084 (2/2) NMT1/THI5 like PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF04199 (2/2) Putative cyclase PF03972 (2/2) MmgE/PrpD family PF03328 (2/2) HpcH/HpaI aldolase/citrate lyase family PF02566 (2/2) OsmC-like protein PF02515 (2/2) CoA-transferase family III PF01979 (2/2) Amidohydrolase family PF01614 (2/2) Bacterial transcriptional regulator PF01546 (2/2) Peptidase family M20/M25/M40 PF00724 (2/2) NADH:flavin oxidoreductase / NADH oxidase family PF00561 (2/2) alpha/beta hydrolase fold PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_jaccard_groups_43169	107.29 +- 28.50	2	0	2	2	0.04 +- 0.04	2	10 TIGR04025 (2/2) pyridoxamine 5'-phosphate oxidase, FMN-binding family TIGR00229 (2/2) PAS domain S-box protein PF08448 (2/2) PAS fold PF08447 (2/2) PAS fold PF08386 (2/2) TAP-like protein PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF05147 (2/2) Lanthionine synthetase C-like protein PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00561 (2/2) alpha/beta hydrolase fold PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_1997	38.95 +- 9.95	7	0	0	0	0.06 +- 0.09	7	5 PF17866 (7/7) AAA lid domain PF13229 (7/7) Right handed beta helix region PF00652 (7/7) Ricin-type beta-trefoil lectin domain PF00082 (7/7) Subtilase family PF00004 (7/7) ATPase family associated with various cellular activities (AAA)
precursor_jaccard_groups_4897	221.77 +- 79.53	9	0	0	0	0.05 +- 0.04	9	10 TIGR00976 (9/9) hydrolase CocE/NonD family protein PF08530 (9/9) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (9/9) alpha/beta hydrolase fold PF07690 (9/9) Major Facilitator Superfamily PF03781 (9/9) Sulfatase-modifying factor enzyme 1 PF02129 (9/9) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (9/9) Phosphotriesterase family PF01494 (9/9) FAD binding domain PF00884 (9/9) Sulfatase PF00753 (9/9) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_17197	1855.31 +- 282.62	3	0	3	0	0.04 +- 0.15	3	33 TIGR04020 (3/3) natural product biosynthesis luciferase-like monooxygenase domain TIGR03856 (3/3) probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR01733 (3/3) amino acid adenylation domain TIGR01686 (3/3) FkbH domain TIGR00976 (3/3) hydrolase CocE/NonD family protein PF18563 (3/3) TubC N-terminal docking domain PF16197 (3/3) Ketoacyl-synthetase C-terminal extension PF14765 (3/3) Polyketide synthase dehydratase PF13602 (3/3) Zinc-binding dehydrogenase PF13193 (3/3) AMP-binding enzyme C-terminal domain PF08659 (3/3) KR domain PF08530 (3/3) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08240 (3/3) Alcohol dehydrogenase GroES-like domain PF03621 (3/3) MbtH-like protein PF02801 (3/3) Beta-ketoacyl synthase, C-terminal domain PF02771 (3/3) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (3/3) Acyl-CoA dehydrogenase, middle domain PF02737 (3/3) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02195 (3/3) ParB-like nuclease domain PF02129 (3/3) X-Pro dipeptidyl-peptidase (S15 family) PF01266 (3/3) FAD dependent oxidoreductase PF00975 (3/3) Thioesterase domain PF00725 (3/3) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (3/3) Acyl transferase domain PF00668 (3/3) Condensation domain PF00664 (3/3) ABC transporter transmembrane region PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00441 (3/3) Acyl-CoA dehydrogenase, C-terminal domain PF00296 (3/3) Luciferase-like monooxygenase PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00109 (3/3) Beta-ketoacyl synthase, N-terminal domain PF00005 (3/3) ABC transporter
precursor_jaccard_groups_25486	1040.00 +- 0.00	2	0	0	2	0.01 +- 0.00	2	6 TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF07690 (2/2) Major Facilitator Superfamily PF05193 (2/2) Peptidase M16 inactive domain PF03358 (2/2) NADPH-dependent FMN reductase PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_jaccard_groups_41790	133.48 +- 31.64	2	0	0	0	0.04 +- 0.04	2	6 PF13649 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF02899 (2/2) Phage integrase, N-terminal SAM-like domain PF01636 (2/2) Phosphotransferase enzyme family PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00293 (2/2) NUDIX domain
precursor_jaccard_groups_8066	858.49 +- 193.39	4	0	4	4	0.01 +- 0.00	4	11 TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain TIGR03797 (4/4) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (4/4) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein TIGR03605 (4/4) SagB-type dehydrogenase domain TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component PF13437 (4/4) HlyD family secretion protein PF03412 (4/4) Peptidase C39 family PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (4/4) Nitroreductase family PF00664 (4/4) ABC transporter transmembrane region PF00005 (4/4) ABC transporter
precursor_jaccard_groups_8416	174.02 +- 47.17	5	0	0	0	0.07 +- 0.10	5	7 PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF12680 (5/5) SnoaL-like domain PF07045 (5/5) Domain of unknown function (DUF1330) PF01738 (5/5) Dienelactone hydrolase family PF00664 (5/5) ABC transporter transmembrane region PF00440 (5/5) Bacterial regulatory proteins, tetR family PF00005 (5/5) ABC transporter
precursor_jaccard_groups_21453	186.14 +- 8.86	2	0	0	0	0.03 +- 0.04	2	6 PF13564 (2/2) DoxX-like family PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF03358 (2/2) NADPH-dependent FMN reductase PF00440 (2/2) Bacterial regulatory proteins, tetR family PF18616 (1/2) CDI immunity proteins
precursor_jaccard_groups_43205	100.28 +- 9.84	2	0	0	0	0.06 +- 0.06	2	6 PF14903 (2/2) WG containing repeat PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF06983 (2/2) 3-demethylubiquinone-9 3-methyltransferase PF00950 (2/2) ABC 3 transport family PF00583 (2/2) Acetyltransferase (GNAT) family PF00005 (2/2) ABC transporter
precursor_jaccard_groups_3309	637.59 +- 4.54	2	0	0	0	0.03 +- 0.02	2	14 TIGR00928 (2/2) adenylosuccinate lyase TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13673 (2/2) Acetyltransferase (GNAT) domain PF13460 (2/2) NAD(P)H-binding PF12800 (2/2) 4Fe-4S binding domain PF07690 (2/2) Major Facilitator Superfamily PF01814 (2/2) Hemerythrin HHE cation binding domain PF01494 (2/2) FAD binding domain PF01425 (2/2) Amidase PF00561 (2/2) alpha/beta hydrolase fold PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00206 (2/2) Lyase PF00120 (2/2) Glutamine synthetase, catalytic domain PF00072 (2/2) Response regulator receiver domain
precursor_jaccard_groups_43369	100.71 +- 10.71	2	0	0	0	0.06 +- 0.04	2	3 PF04672 (2/2) S-adenosyl methyltransferase PF01872 (2/2) RibD C-terminal domain PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_11383	336.40 +- 91.11	4	0	0	0	0.01 +- 0.01	4	4 PF13649 (4/4) Methyltransferase domain PF07730 (4/4) Histidine kinase PF00196 (4/4) Bacterial regulatory proteins, luxR family PF00072 (4/4) Response regulator receiver domain
precursor_jaccard_groups_26078	627.35 +- 64.02	2	0	0	2	0.01 +- 0.01	2	10 PF13191 (2/2) AAA ATPase domain PF13185 (2/2) GAF domain PF04055 (2/2) Radical SAM superfamily PF03704 (2/2) Bacterial transcriptional activator domain PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00082 (2/2) Subtilase family PF07690 (1/2) Major Facilitator Superfamily PF05977 (1/2) Transmembrane secretion effector
precursor_jaccard_groups_9943	166.79 +- 16.68	2	0	2	0	0.05 +- 0.06	2	10 PF17137 (2/2) Domain of unknown function (DUF5110) PF16338 (2/2) Domain of unknown function (DUF4968) PF13520 (2/2) Amino acid permease PF07730 (2/2) Histidine kinase PF03466 (2/2) LysR substrate binding domain PF01055 (2/2) Glycosyl hydrolases family 31 PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00072 (2/2) Response regulator receiver domain PF00069 (2/2) Protein kinase domain
precursor_jaccard_groups_29968	274.58 +- 189.71	2	0	2	0	0.03 +- 0.05	2	10 PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF08659 (2/2) KR domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF00698 (2/2) Acyl transferase domain PF00561 (2/2) alpha/beta hydrolase fold PF00550 (2/2) Phosphopantetheine attachment site PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_5577	183.10 +- 82.91	6	0	0	0	0.01 +- 0.01	6	1 PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase
precursor_jaccard_groups_10911	592.86 +- 404.30	3	0	0	0	0.05 +- 0.08	3	7 PF13411 (3/3) MerR HTH family regulatory protein PF07739 (3/3) TipAS antibiotic-recognition domain PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain PF01551 (3/3) Peptidase family M23 PF00392 (3/3) Bacterial regulatory proteins, gntR family PF00005 (3/3) ABC transporter PF12679 (2/3) ABC-2 family transporter protein
precursor_jaccard_groups_35210	100.79 +- 5.13	2	0	0	0	0.06 +- 0.07	2	14 TIGR01891 (2/2) amidohydrolase PF13738 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF13302 (2/2) Acetyltransferase (GNAT) domain PF13091 (2/2) PLD-like domain PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF06267 (2/2) Family of unknown function (DUF1028) PF03466 (2/2) LysR substrate binding domain PF02386 (2/2) Cation transport protein PF02254 (2/2) TrkA-N domain PF02080 (2/2) TrkA-C domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01042 (2/2) Endoribonuclease L-PSP PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00083 (2/2) Sugar (and other) transporter
precursor_jaccard_groups_18487	358.75 +- 32.16	2	0	0	0	0.01 +- 0.01	2	18 TIGR01558 (2/2) putative phage terminase, small subunit, P27 family TIGR01554 (2/2) phage major capsid protein, HK97 family TIGR01543 (2/2) phage prohead protease, HK97 family TIGR01537 (2/2) phage portal protein, HK97 family PF14594 (2/2) Siphovirus ReqiPepy6 Gp37-like protein PF10145 (2/2) Phage-related minor tail protein PF05119 (2/2) Phage terminase, small subunit PF05065 (2/2) Phage capsid family PF04860 (2/2) Phage portal protein PF04851 (2/2) Type III restriction enzyme, res subunit PF04586 (2/2) Caudovirus prohead serine protease PF04542 (2/2) Sigma-70 region 2 PF03354 (2/2) Phage Terminase PF01844 (2/2) HNH endonuclease PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase PF01391 (2/2) Collagen triple helix repeat (20 copies) PF01381 (2/2) Helix-turn-helix PF00271 (2/2) Helicase conserved C-terminal domain
precursor_jaccard_groups_43014	1363.59 +- 571.41	2	0	0	0	0.01 +- 0.01	2	17 TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF13183 (2/2) 4Fe-4S dicluster domain PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07729 (2/2) FCD domain PF03737 (2/2) Aldolase/RraA PF02913 (2/2) FAD linked oxidases, C-terminal domain PF02754 (2/2) Cysteine-rich domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01565 (2/2) FAD binding domain PF01229 (2/2) Glycosyl hydrolases family 39 PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7559	320.07 +- 19.07	2	0	2	0	0.05 +- 0.02	2	18 TIGR00976 (2/2) hydrolase CocE/NonD family protein PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12697 (2/2) Alpha/beta hydrolase family PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF04909 (2/2) Amidohydrolase PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF01144 (2/2) Coenzyme A transferase PF00501 (2/2) AMP-binding enzyme PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00106 (2/2) short chain dehydrogenase PF00005 (2/2) ABC transporter PF01965 (1/2) DJ-1/PfpI family
precursor_jaccard_groups_30	272.98 +- 0.99	3	0	3	0	0.09 +- 0.18	3	11 TIGR03797 (3/3) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (3/3) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein PF10604 (3/3) Polyketide cyclase / dehydrase and lipid transport PF07690 (3/3) Major Facilitator Superfamily PF05013 (3/3) N-formylglutamate amidohydrolase PF03412 (3/3) Peptidase C39 family PF03055 (3/3) Retinal pigment epithelial membrane protein PF00664 (3/3) ABC transporter transmembrane region PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00005 (3/3) ABC transporter PF13437 (2/3) HlyD family secretion protein
precursor_jaccard_groups_36	326.29 +- 70.74	5	0	0	0	0.07 +- 0.20	5	16 PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like PF00691 (5/5) OmpA family PF00482 (5/5) Type II secretion system (T2SS), protein F TIGR03177 (4/5) Flp pilus assembly protein CpaB PF16976 (4/5) Flp pilus assembly protein RcpC/CpaB PF13614 (4/5) AAA domain PF07811 (4/5) TadE-like protein PF07730 (4/5) Histidine kinase PF00437 (4/5) Type II/IV secretion system protein PF00196 (4/5) Bacterial regulatory proteins, luxR family PF00072 (4/5) Response regulator receiver domain PF15648 (3/5) Restriction endonuclease fold toxin 5 PF13231 (3/5) Dolichyl-phosphate-mannose-protein mannosyltransferase PF00528 (3/5) Binding-protein-dependent transport system inner membrane component PF00496 (3/5) Bacterial extracellular solute-binding proteins, family 5 Middle PF00005 (3/5) ABC transporter
precursor_jaccard_groups_531	366.81 +- 92.54	7	0	7	7	0.07 +- 0.08	7	12 TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (7/7) SagB-type dehydrogenase domain TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term PF13191 (7/7) AAA ATPase domain PF04738 (7/7) Lantibiotic dehydratase, N terminus PF03704 (7/7) Bacterial transcriptional activator domain PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (7/7) ABC-2 type transporter PF00881 (7/7) Nitroreductase family PF00486 (7/7) Transcriptional regulatory protein, C terminal PF00005 (7/7) ABC transporter
precursor_jaccard_groups_26233	117.00 +- 13.00	2	0	2	0	0.02 +- 0.01	2	4 PF08386 (2/2) TAP-like protein PF08031 (2/2) Berberine and berberine like PF01565 (2/2) FAD binding domain PF00561 (2/2) alpha/beta hydrolase fold
precursor_jaccard_groups_5776	795.64 +- 536.08	8	0	8	8	0.03 +- 0.08	8	12 TIGR03882 (8/8) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (8/8) SagB-type dehydrogenase domain TIGR03604 (8/8) thiazole/oxazole-forming peptide maturase, SagD family component PF13575 (8/8) Domain of unknown function (DUF4135) PF03412 (8/8) Peptidase C39 family PF02624 (8/8) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (8/8) Nitroreductase family PF00664 (8/8) ABC transporter transmembrane region PF00067 (8/8) Cytochrome P450 PF00005 (8/8) ABC transporter PF00364 (6/8) Biotin-requiring enzyme PF05147 (4/8) Lanthionine synthetase C-like protein
precursor_jaccard_groups_24455	155.40 +- 85.40	2	0	0	0	0.04 +- 0.04	2	6 TIGR03921 (2/2) type VII secretion-associated serine protease mycosin PF07729 (2/2) FCD domain PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00293 (2/2) NUDIX domain PF00221 (2/2) Aromatic amino acid lyase PF00082 (2/2) Subtilase family
precursor_jaccard_groups_11745	51.32 +- 24.99	3	0	0	0	0.05 +- 0.06	3	7 PF13424 (3/3) Tetratricopeptide repeat PF07719 (3/3) Tetratricopeptide repeat PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif PF03413 (3/3) Peptidase propeptide and YPEB domain PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain PF00348 (3/3) Polyprenyl synthetase
precursor_jaccard_groups_7987	383.81 +- 168.05	5	0	0	5	0.01 +- 0.03	5	7 TIGR00702 (5/5) YcaO-type kinase domain PF18029 (5/5) Glyoxalase-like domain PF13489 (5/5) Methyltransferase domain PF13231 (5/5) Dolichyl-phosphate-mannose-protein mannosyltransferase PF07812 (5/5) TfuA-like protein PF07690 (5/5) Major Facilitator Superfamily PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
precursor_jaccard_groups_24517	1607.67 +- 212.33	2	0	2	0	0.01 +- 0.00	2	31 TIGR01733 (2/2) amino acid adenylation domain TIGR01686 (2/2) FkbH domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF17759 (2/2) Phenylalanyl tRNA synthetase beta chain CLM domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF13649 (2/2) Methyltransferase domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12844 (2/2) Helix-turn-helix domain PF08892 (2/2) YqcI/YcgG family PF07690 (2/2) Major Facilitator Superfamily PF03486 (2/2) HI0933-like protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02780 (2/2) Transketolase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02737 (2/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF01636 (2/2) Phosphotransferase enzyme family PF01409 (2/2) tRNA synthetases class II core domain (F) PF00725 (2/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF17874 (1/2) MalT-like TPR region
precursor_jaccard_groups_10967	68.37 +- 29.84	3	0	0	0	0.07 +- 0.06	3	8 TIGR00350 (3/3) cell envelope-related function transcriptional attenuator common domain PF13399 (3/3) LytR cell envelope-related transcriptional attenuator PF07859 (3/3) alpha/beta hydrolase fold PF03816 (3/3) Cell envelope-related transcriptional attenuator domain PF03807 (3/3) NADP oxidoreductase coenzyme F420-dependent PF01258 (3/3) Prokaryotic dksA/traR C4-type zinc finger PF00768 (3/3) D-alanyl-D-alanine carboxypeptidase PF00459 (3/3) Inositol monophosphatase family
precursor_jaccard_groups_1313	427.40 +- 123.00	2	0	2	0	0.03 +- 0.03	2	6 TIGR03892 (2/2) thiazolylpeptide-type bacteriocin precursor PF13193 (2/2) AMP-binding enzyme C-terminal domain PF01959 (2/2) 3-dehydroquinate synthase II PF01791 (2/2) DeoC/LacD family aldolase PF01494 (2/2) FAD binding domain PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_4352	479.19 +- 156.31	9	0	9	9	0.02 +- 0.01	9	7 PF07690 (9/9) Major Facilitator Superfamily PF04055 (9/9) Radical SAM superfamily PF03466 (9/9) LysR substrate binding domain PF02310 (9/9) B12 binding domain PF00733 (9/9) Asparagine synthase PF00501 (9/9) AMP-binding enzyme PF00126 (9/9) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_17640	977.21 +- 452.79	2	0	2	2	0.01 +- 0.02	2	25 TIGR04504 (2/2) SDR family mycofactocin-dependent oxidoreductase TIGR03969 (2/2) mycofactocin precursor TIGR03967 (2/2) putative mycofactocin binding protein MftB TIGR03966 (2/2) heme/flavin dehydrogenase, mycofactocin system TIGR03965 (2/2) mycofactocin system glycosyltransferase TIGR03964 (2/2) mycofactocin system creatininase family protein TIGR03962 (2/2) mycofactocin radical SAM maturase PF17676 (2/2) LD-carboxypeptidase C-terminal domain PF16861 (2/2) Carbamoyltransferase C-terminus PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13489 (2/2) Methyltransferase domain PF13186 (2/2) Iron-sulfur cluster-binding domain PF08242 (2/2) Methyltransferase domain PF04055 (2/2) Radical SAM superfamily PF03129 (2/2) Anticodon binding domain PF02633 (2/2) Creatinine amidohydrolase PF02543 (2/2) Carbamoyltransferase N-terminus PF02016 (2/2) LD-carboxypeptidase N-terminal domain PF01980 (2/2) tRNA-methyltransferase O PF01070 (2/2) FMN-dependent dehydrogenase PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00587 (2/2) tRNA synthetase class II core domain (G, H, P, S and T) PF00535 (2/2) Glycosyl transferase family 2 PF00152 (2/2) tRNA synthetases class II (D, K and N) PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_26806	227.25 +- 162.75	2	0	0	0	0.03 +- 0.05	2	7 TIGR01840 (2/2) esterase, PHB depolymerase family PF10503 (2/2) Esterase PHB depolymerase PF08223 (2/2) PaaX-like protein C-terminal domain PF07848 (2/2) PaaX-like protein PF00652 (2/2) Ricin-type beta-trefoil lectin domain PF00553 (2/2) Cellulose binding domain PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_30307	237.03 +- 98.37	2	0	0	0	0.02 +- 0.04	2	9 TIGR03930 (2/2) WXG100 family type VII secretion target TIGR03920 (2/2) type VII secretion integral membrane protein EccD TIGR03919 (2/2) type VII secretion protein EccB PF15644 (2/2) Papain fold toxin 1, glutamine deamidase PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like PF08817 (2/2) WXG100 protein secretion system (Wss), protein YukD PF06013 (2/2) Proteins of 100 residues with WXG PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B PF02575 (2/2) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_6905	276.85 +- 62.50	3	0	0	0	0.02 +- 0.02	3	5 PF13924 (3/3) Lipocalin-like domain PF07690 (3/3) Major Facilitator Superfamily PF00857 (3/3) Isochorismatase family PF00171 (3/3) Aldehyde dehydrogenase family PF00082 (2/3) Subtilase family
precursor_jaccard_groups_20179	47.53 +- 2.00	2	0	0	0	0.06 +- 0.06	2	3 PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
precursor_jaccard_groups_4527	119.08 +- 0.00	2	0	0	0	0.03 +- 0.01	2	6 TIGR03930 (2/2) WXG100 family type VII secretion target TIGR03921 (2/2) type VII secretion-associated serine protease mycosin TIGR03919 (2/2) type VII secretion protein EccB PF06013 (2/2) Proteins of 100 residues with WXG PF05108 (2/2) Type VII secretion system ESX-1, transport TM domain B PF00082 (2/2) Subtilase family
precursor_jaccard_groups_14333	125.56 +- 76.73	4	0	0	0	0.02 +- 0.01	4	4 TIGR03083 (4/4) uncharacterized Actinobacterial protein TIGR03083 PF11716 (4/4) Mycothiol maleylpyruvate isomerase N-terminal domain PF10977 (4/4) Protein of unknown function (DUF2797) PF07398 (4/4) MDMPI C-terminal domain
precursor_jaccard_groups_710	1621.00 +- 1136.16	31	0	7	0	0.02 +- 0.06	31	9 PF17914 (31/31) HopA1 effector protein family PF00664 (31/31) ABC transporter transmembrane region PF00296 (31/31) Luciferase-like monooxygenase PF00005 (31/31) ABC transporter PF02441 (30/31) Flavoprotein PF00675 (30/31) Insulinase (Peptidase family M16) PF05193 (26/31) Peptidase M16 inactive domain PF00891 (26/31) O-methyltransferase domain PF01636 (25/31) Phosphotransferase enzyme family
precursor_jaccard_groups_1823	675.94 +- 720.50	12	0	12	1	0.03 +- 0.12	12	14 TIGR01850 (12/12) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (12/12) alpha-L-glutamate ligase, RimK family PF13193 (12/12) AMP-binding enzyme C-terminal domain PF08443 (12/12) RimK-like ATP-grasp domain PF02780 (12/12) Transketolase, C-terminal domain PF02779 (12/12) Transketolase, pyrimidine binding domain PF02771 (12/12) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (12/12) Acyl-CoA dehydrogenase, middle domain PF01118 (12/12) Semialdehyde dehydrogenase, NAD binding domain PF00501 (12/12) AMP-binding enzyme PF00456 (12/12) Transketolase, thiamine diphosphate binding domain PF00441 (12/12) Acyl-CoA dehydrogenase, C-terminal domain PF03466 (9/12) LysR substrate binding domain PF00126 (9/12) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_8841	303.45 +- 53.54	3	0	0	0	0.02 +- 0.01	3	8 PF17286 (3/3) PRMT5 oligomerisation domain PF14518 (3/3) Iron-containing redox enzyme PF13649 (3/3) Methyltransferase domain PF07732 (3/3) Multicopper oxidase PF01323 (3/3) DSBA-like thioredoxin domain PF00701 (3/3) Dihydrodipicolinate synthetase family PF00355 (3/3) Rieske [2Fe-2S] domain PF00155 (3/3) Aminotransferase class I and II
precursor_jaccard_groups_43944	69.46 +- 4.96	2	0	0	0	0.04 +- 0.04	2	8 TIGR03026 (2/2) nucleotide sugar dehydrogenase TIGR00711 (2/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF07690 (2/2) Major Facilitator Superfamily PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00201 (2/2) UDP-glucoronosyl and UDP-glucosyl transferase PF12802 (1/2) MarR family
precursor_jaccard_groups_2843	4220.18 +- 876.74	7	4	3	7	0.01 +- 0.01	3	13 TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (7/7) SagB-type dehydrogenase domain TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (6/7) Nitroreductase family PF00440 (6/7) Bacterial regulatory proteins, tetR family PF00067 (6/7) Cytochrome P450 TIGR01891 (5/7) amidohydrolase PF01546 (5/7) Peptidase family M20/M25/M40 PF00005 (5/7) ABC transporter PF04738 (4/7) Lantibiotic dehydratase, N terminus PF01061 (4/7) ABC-2 type transporter
precursor_jaccard_groups_14422	43.41 +- 0.41	2	0	2	0	0.07 +- 0.09	2	5 PF13472 (2/2) GDSL-like Lipase/Acylhydrolase family PF07690 (2/2) Major Facilitator Superfamily PF00905 (2/2) Penicillin binding protein transpeptidase domain PF00266 (2/2) Aminotransferase class-V PF00171 (2/2) Aldehyde dehydrogenase family
precursor_jaccard_groups_4553	235.19 +- 41.40	6	0	1	0	0.02 +- 0.01	6	7 TIGR03920 (6/6) type VII secretion integral membrane protein EccD TIGR03919 (6/6) type VII secretion protein EccB PF08817 (6/6) WXG100 protein secretion system (Wss), protein YukD PF07179 (6/6) SseB protein N-terminal domain PF05108 (6/6) Type VII secretion system ESX-1, transport TM domain B PF04488 (6/6) Glycosyltransferase sugar-binding region containing DXD motif PF02575 (6/6) YbaB/EbfC DNA-binding family
precursor_jaccard_groups_660	133.51 +- 85.83	9	0	0	0	0.03 +- 0.02	9	4 PF01471 (9/9) Putative peptidoglycan binding domain PF00561 (9/9) alpha/beta hydrolase fold PF08386 (8/9) TAP-like protein PF13515 (6/9) Fusaric acid resistance protein-like
precursor_jaccard_groups_6440	216.00 +- 44.00	2	0	0	0	0.03 +- 0.04	2	4 TIGR01910 (2/2) peptidase, ArgE/DapE family PF01546 (2/2) Peptidase family M20/M25/M40 PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase PF00107 (1/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_651	2220.43 +- 119.57	2	0	0	0	0.01 +- 0.00	2	8 PF14081 (2/2) Domain of unknown function (DUF4262) PF13400 (2/2) Putative Flp pilus-assembly TadE/G-like PF08666 (2/2) SAF domain PF07811 (2/2) TadE-like protein PF01476 (2/2) LysM domain PF01381 (2/2) Helix-turn-helix PF00482 (2/2) Type II secretion system (T2SS), protein F PF00437 (2/2) Type II/IV secretion system protein
precursor_jaccard_groups_4416	125.11 +- 36.14	2	0	0	0	0.05 +- 0.06	2	13 TIGR01180 (2/2) putative alpha-1,2-mannosidase PF17678 (2/2) Glycosyl hydrolase family 92 N-terminal domain PF07971 (2/2) Glycosyl hydrolase family 92 PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00672 (2/2) HAMP domain PF00553 (2/2) Cellulose binding domain PF00512 (2/2) His Kinase A (phospho-acceptor) domain TIGR01766 (1/2) transposase, IS605 OrfB family PF07282 (1/2) Putative transposase DNA-binding domain PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF01385 (1/2) Probable transposase PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00072 (1/2) Response regulator receiver domain
precursor_jaccard_groups_9210	622.29 +- 125.90	3	0	3	0	0.01 +- 0.02	3	9 TIGR01250 (3/3) proline-specific peptidase PF13370 (3/3) 4Fe-4S single cluster domain of Ferredoxin I PF06368 (3/3) Methylaspartate mutase E chain (MutE) PF02784 (3/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain PF02310 (3/3) B12 binding domain PF00561 (3/3) alpha/beta hydrolase fold PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_9269	43.48 +- 8.68	3	0	0	0	0.07 +- 0.05	3	9 PF13478 (3/3) XdhC Rossmann domain PF09339 (3/3) IclR helix-turn-helix domain PF03450 (3/3) CO dehydrogenase flavoprotein C-terminal domain PF02738 (3/3) Molybdopterin-binding domain of aldehyde dehydrogenase PF02625 (3/3) XdhC and CoxI family PF01799 (3/3) [2Fe-2S] binding domain PF01315 (3/3) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (3/3) FAD binding domain in molybdopterin dehydrogenase PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_28703	1580.73 +- 635.73	2	0	2	0	0.02 +- 0.04	2	14 PF13649 (2/2) Methyltransferase domain PF05193 (2/2) Peptidase M16 inactive domain PF03965 (2/2) Penicillinase repressor PF01937 (2/2) Protein of unknown function DUF89 PF01475 (2/2) Ferric uptake regulator family PF01435 (2/2) Peptidase family M48 PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01061 (2/2) ABC-2 type transporter PF00675 (2/2) Insulinase (Peptidase family M16) PF00583 (2/2) Acetyltransferase (GNAT) family PF00391 (2/2) PEP-utilising enzyme, mobile domain PF00300 (2/2) Histidine phosphatase superfamily (branch 1) PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter
precursor_jaccard_groups_13407	1191.19 +- 1181.25	4	1	1	4	0.05 +- 0.18	3	22 TIGR03605 (4/4) SagB-type dehydrogenase domain TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF08241 (4/4) Methyltransferase domain PF07993 (4/4) Male sterility protein PF03364 (4/4) Polyketide cyclase / dehydrase and lipid transport PF03176 (4/4) MMPL family PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (4/4) Nitroreductase family PF00698 (4/4) Acyl transferase domain PF00550 (4/4) Phosphopantetheine attachment site PF00202 (4/4) Aminotransferase class-III PF00196 (4/4) Bacterial regulatory proteins, luxR family PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain TIGR03882 (3/4) bacteriocin biosynthesis cyclodehydratase domain PF03473 (3/4) MOSC domain PF01575 (3/4) MaoC like domain PF00675 (3/4) Insulinase (Peptidase family M16) PF05193 (2/4) Peptidase M16 inactive domain PF03476 (2/4) MOSC N-terminal beta barrel domain PF00106 (2/4) short chain dehydrogenase
precursor_jaccard_groups_826	120.00 +- 0.00	2	0	0	0	0.10 +- 0.25	2	12 TIGR00229 (2/2) PAS domain S-box protein PF08795 (2/2) Putative papain-like cysteine peptidase (DUF1796) PF03098 (2/2) Animal haem peroxidase PF02585 (2/2) GlcNAc-PI de-N-acetylase PF01061 (2/2) ABC-2 type transporter PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain PF00582 (2/2) Universal stress protein family PF00199 (2/2) Catalase PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF08448 (1/2) PAS fold PF00989 (1/2) PAS fold
precursor_jaccard_groups_981	222.67 +- 78.34	11	0	0	0	0.03 +- 0.02	11	10 TIGR03930 (11/11) WXG100 family type VII secretion target TIGR03920 (11/11) type VII secretion integral membrane protein EccD TIGR03919 (11/11) type VII secretion protein EccB PF15644 (11/11) Papain fold toxin 1, glutamine deamidase PF08817 (11/11) WXG100 protein secretion system (Wss), protein YukD PF07179 (11/11) SseB protein N-terminal domain PF06013 (11/11) Proteins of 100 residues with WXG PF05108 (11/11) Type VII secretion system ESX-1, transport TM domain B PF02575 (11/11) YbaB/EbfC DNA-binding family PF00652 (11/11) Ricin-type beta-trefoil lectin domain
precursor_jaccard_groups_1387	174.09 +- 18.88	3	0	0	0	0.07 +- 0.09	3	14 PF18565 (3/3) Glycoside hydrolase family 2 C-terminal domain 5 PF17390 (3/3) Bacterial alpha-L-rhamnosidase C-terminal domain PF17389 (3/3) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PF16355 (3/3) Domain of unknown function (DUF4982) PF14310 (3/3) Fibronectin type III-like domain PF13561 (3/3) Enoyl-(Acyl carrier protein) reductase PF08531 (3/3) Alpha-L-rhamnosidase N-terminal domain PF07859 (3/3) alpha/beta hydrolase fold PF05592 (3/3) Bacterial alpha-L-rhamnosidase concanavalin-like domain PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain PF01915 (3/3) Glycosyl hydrolase family 3 C-terminal domain PF00933 (3/3) Glycosyl hydrolase family 3 N terminal domain PF00703 (3/3) Glycosyl hydrolases family 2
precursor_jaccard_groups_31238	142.22 +- 29.78	2	0	2	0	0.06 +- 0.03	2	8 PF18368 (2/2) Exo-beta-D-glucosaminidase Ig-fold domain PF07690 (2/2) Major Facilitator Superfamily PF03466 (2/2) LysR substrate binding domain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00754 (2/2) F5/8 type C domain PF00703 (2/2) Glycosyl hydrolases family 2 PF00126 (2/2) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_16546	24.19 +- 0.00	2	0	0	0	0.08 +- 0.03	2	2 PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF01361 (2/2) Tautomerase enzyme
precursor_jaccard_groups_6978	47.10 +- 5.79	3	0	0	0	0.06 +- 0.05	3	5 TIGR03083 (3/3) uncharacterized Actinobacterial protein TIGR03083 PF13302 (3/3) Acetyltransferase (GNAT) domain PF11716 (3/3) Mycothiol maleylpyruvate isomerase N-terminal domain PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02036 (3/3) SCP-2 sterol transfer family
precursor_jaccard_groups_43400	971.25 +- 3.75	2	0	0	0	0.01 +- 0.00	2	5 PF13416 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF00962 (2/2) Adenosine/AMP deaminase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00005 (2/2) ABC transporter
precursor_jaccard_groups_35828	694.47 +- 44.47	2	0	2	2	0.01 +- 0.00	2	9 TIGR03975 (2/2) ribosomal peptide maturation radical SAM protein 1 PF13649 (2/2) Methyltransferase domain PF07690 (2/2) Major Facilitator Superfamily PF05193 (2/2) Peptidase M16 inactive domain PF04989 (2/2) Cephalosporin hydroxylase PF04055 (2/2) Radical SAM superfamily PF02310 (2/2) B12 binding domain PF00805 (2/2) Pentapeptide repeats (8 copies) PF00675 (2/2) Insulinase (Peptidase family M16)
precursor_jaccard_groups_34206	306.43 +- 83.57	2	0	2	0	0.01 +- 0.00	2	7 PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF07690 (2/2) Major Facilitator Superfamily PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00155 (2/2) Aminotransferase class I and II
precursor_jaccard_groups_28096	777.00 +- 3.00	2	0	0	0	0.01 +- 0.00	2	8 PF14759 (2/2) Reductase C-terminal PF13279 (2/2) Thioesterase-like superfamily PF07992 (2/2) Pyridine nucleotide-disulphide oxidoreductase PF01613 (2/2) Flavin reductase like domain PF00775 (2/2) Dioxygenase PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_11184	144.69 +- 113.31	2	0	0	0	0.04 +- 0.06	2	5 PF18593 (2/2) CdiI immunity protein PF18431 (2/2) Bacterial CdiA-CT RNAse A domain PF13560 (2/2) Helix-turn-helix domain PF06013 (2/2) Proteins of 100 residues with WXG PF04149 (2/2) Domain of unknown function (DUF397)
precursor_jaccard_groups_1003	472.48 +- 223.76	3	0	3	0	0.05 +- 0.13	3	15 TIGR01733 (3/3) amino acid adenylation domain PF13560 (3/3) Helix-turn-helix domain PF13193 (3/3) AMP-binding enzyme C-terminal domain PF07690 (3/3) Major Facilitator Superfamily PF06368 (3/3) Methylaspartate mutase E chain (MutE) PF03621 (3/3) MbtH-like protein PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family PF02310 (3/3) B12 binding domain PF01645 (3/3) Conserved region in glutamate synthase PF00975 (3/3) Thioesterase domain PF00668 (3/3) Condensation domain PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00152 (3/3) tRNA synthetases class II (D, K and N) PF01648 (2/3) 4'-phosphopantetheinyl transferase superfamily
precursor_jaccard_groups_20536	97.43 +- 4.08	3	0	0	0	0.02 +- 0.02	3	2 PF01636 (3/3) Phosphotransferase enzyme family PF00300 (3/3) Histidine phosphatase superfamily (branch 1)
precursor_jaccard_groups_7977	371.41 +- 284.77	6	0	0	0	0.03 +- 0.08	6	16 TIGR01060 (6/6) phosphopyruvate hydratase PF18603 (6/6) L-amino acid ligase C-terminal domain 2 PF18130 (6/6) ATP-grasp N-terminal domain PF16861 (6/6) Carbamoyltransferase C-terminus PF14518 (6/6) Iron-containing redox enzyme PF13535 (6/6) ATP-grasp domain PF13472 (6/6) GDSL-like Lipase/Acylhydrolase family PF07690 (6/6) Major Facilitator Superfamily PF06089 (6/6) L-asparaginase II PF03952 (6/6) Enolase, N-terminal domain PF02776 (6/6) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (6/6) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02543 (6/6) Carbamoyltransferase N-terminus PF00291 (6/6) Pyridoxal-phosphate dependent enzyme PF00205 (6/6) Thiamine pyrophosphate enzyme, central domain PF00113 (6/6) Enolase, C-terminal TIM barrel domain
precursor_jaccard_groups_12000	233.66 +- 123.26	4	0	0	0	0.02 +- 0.03	4	6 PF13305 (4/4) Tetracyclin repressor-like, C-terminal domain PF07690 (4/4) Major Facilitator Superfamily PF05922 (4/4) Peptidase inhibitor I9 PF00535 (4/4) Glycosyl transferase family 2 PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00082 (4/4) Subtilase family
precursor_jaccard_groups_3188	358.32 +- 74.43	10	0	6	0	0.06 +- 0.03	10	18 PF13561 (10/10) Enoyl-(Acyl carrier protein) reductase PF08545 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (10/10) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02801 (10/10) Beta-ketoacyl synthase, C-terminal domain PF01144 (10/10) Coenzyme A transferase PF00378 (10/10) Enoyl-CoA hydratase/isomerase PF00196 (10/10) Bacterial regulatory proteins, luxR family PF00109 (10/10) Beta-ketoacyl synthase, N-terminal domain PF00106 (10/10) short chain dehydrogenase PF00005 (10/10) ABC transporter TIGR00976 (9/10) hydrolase CocE/NonD family protein PF13193 (9/10) AMP-binding enzyme C-terminal domain PF12679 (9/10) ABC-2 family transporter protein PF08530 (9/10) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (9/10) X-Pro dipeptidyl-peptidase (S15 family) PF00501 (9/10) AMP-binding enzyme PF04909 (8/10) Amidohydrolase PF12697 (7/10) Alpha/beta hydrolase family
precursor_jaccard_groups_32135	372.32 +- 128.18	2	0	0	0	0.03 +- 0.03	2	9 TIGR01409 (2/2) Tat (twin-arginine translocation) pathway signal sequence PF13377 (2/2) Periplasmic binding protein-like domain PF12833 (2/2) Helix-turn-helix domain PF02065 (2/2) Melibiase PF01965 (2/2) DJ-1/PfpI family PF01547 (2/2) Bacterial extracellular solute-binding protein PF00652 (2/2) Ricin-type beta-trefoil lectin domain PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_34449	571.90 +- 331.10	2	0	0	0	0.02 +- 0.03	2	9 TIGR03083 (2/2) uncharacterized Actinobacterial protein TIGR03083 PF17964 (2/2) Bacterial Ig domain PF11716 (2/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF07702 (2/2) UTRA domain PF07398 (2/2) MDMPI C-terminal domain PF03734 (2/2) L,D-transpeptidase catalytic domain PF01381 (2/2) Helix-turn-helix PF00931 (2/2) NB-ARC domain PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_1645	333.77 +- 152.43	6	0	1	0	0.02 +- 0.03	6	6 PF07291 (6/6) Methylamine utilisation protein MauE PF00717 (6/6) Peptidase S24-like PF00578 (6/6) AhpC/TSA family PF00005 (6/6) ABC transporter PF12833 (4/6) Helix-turn-helix domain PF10502 (3/6) Signal peptidase, peptidase S26
precursor_jaccard_groups_8196	273.59 +- 115.10	6	0	0	0	0.03 +- 0.01	6	7 PF07690 (6/6) Major Facilitator Superfamily PF05378 (6/6) Hydantoinase/oxoprolinase N-terminal region PF02538 (6/6) Hydantoinase B/oxoprolinase PF01968 (6/6) Hydantoinase/oxoprolinase PF01380 (6/6) SIS domain PF01019 (6/6) Gamma-glutamyltranspeptidase PF00294 (6/6) pfkB family carbohydrate kinase
precursor_jaccard_groups_3616	196.34 +- 50.80	5	0	0	0	0.08 +- 0.07	5	10 TIGR01726 (5/5) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family TIGR00976 (5/5) hydrolase CocE/NonD family protein PF08530 (5/5) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (5/5) X-Pro dipeptidyl-peptidase (S15 family) PF01244 (5/5) Membrane dipeptidase (Peptidase family M19) PF00583 (5/5) Acetyltransferase (GNAT) family PF00528 (5/5) Binding-protein-dependent transport system inner membrane component PF00497 (5/5) Bacterial extracellular solute-binding proteins, family 3 PF00005 (5/5) ABC transporter PF00296 (3/5) Luciferase-like monooxygenase
precursor_jaccard_groups_14902	253.73 +- 93.57	2	0	0	0	0.05 +- 0.06	2	11 PF12802 (2/2) MarR family PF09339 (2/2) IclR helix-turn-helix domain PF07883 (2/2) Cupin domain PF07690 (2/2) Major Facilitator Superfamily PF01614 (2/2) Bacterial transcriptional regulator PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family PF01494 (2/2) FAD binding domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF04909 (1/2) Amidohydrolase PF04199 (1/2) Putative cyclase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_19995	212.38 +- 67.73	3	0	3	3	0.04 +- 0.06	3	11 TIGR03975 (3/3) ribosomal peptide maturation radical SAM protein 1 TIGR02937 (3/3) RNA polymerase sigma factor, sigma-70 family PF10025 (3/3) Uncharacterized conserved protein (DUF2267) PF08281 (3/3) Sigma-70, region 4 PF07690 (3/3) Major Facilitator Superfamily PF04542 (3/3) Sigma-70 region 2 PF04055 (3/3) Radical SAM superfamily PF02310 (3/3) B12 binding domain PF00355 (3/3) Rieske [2Fe-2S] domain PF00326 (3/3) Prolyl oligopeptidase family PF00067 (3/3) Cytochrome P450
precursor_jaccard_groups_19998	24.99 +- 2.38	2	0	0	0	0.08 +- 0.07	2	3 PF00652 (2/2) Ricin-type beta-trefoil lectin domain PF00457 (2/2) Glycosyl hydrolases family 11 PF00331 (2/2) Glycosyl hydrolase family 10
precursor_jaccard_groups_30270	1430.00 +- 130.00	2	0	2	2	0.01 +- 0.00	2	16 TIGR00566 (2/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase PF18105 (2/2) PGM1 C-terminal domain PF16861 (2/2) Carbamoyltransferase C-terminus PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF06969 (2/2) HemN C-terminal domain PF05977 (2/2) Transmembrane secretion effector PF04055 (2/2) Radical SAM superfamily PF02543 (2/2) Carbamoyltransferase N-terminus PF00975 (2/2) Thioesterase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00425 (2/2) chorismate binding enzyme PF00117 (2/2) Glutamine amidotransferase class-I PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
precursor_jaccard_groups_14043	332.84 +- 267.53	3	0	0	0	0.06 +- 0.12	3	18 TIGR01088 (3/3) 3-dehydroquinate dehydratase, type II PF18317 (3/3) Shikimate 5'-dehydrogenase C-terminal domain PF09339 (3/3) IclR helix-turn-helix domain PF08501 (3/3) Shikimate dehydrogenase substrate binding domain PF07836 (3/3) DmpG-like communication domain PF07690 (3/3) Major Facilitator Superfamily PF02627 (3/3) Carboxymuconolactone decarboxylase family PF01614 (3/3) Bacterial transcriptional regulator PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family PF01261 (3/3) Xylose isomerase-like TIM barrel PF01220 (3/3) Dehydroquinase class II PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00682 (3/3) HMGL-like PF00083 (3/3) Sugar (and other) transporter TIGR03217 (2/3) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (2/3) acetaldehyde dehydrogenase (acetylating) PF09290 (2/3) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF01118 (2/3) Semialdehyde dehydrogenase, NAD binding domain
precursor_jaccard_groups_26753	21.30 +- 0.66	2	0	0	0	0.09 +- 0.13	2	5 TIGR01701 (2/2) oxidoreductase alpha (molybdopterin) subunit PF07077 (2/2) Protein of unknown function (DUF1345) PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport PF01568 (2/2) Molydopterin dinucleotide binding domain PF00384 (2/2) Molybdopterin oxidoreductase
precursor_jaccard_groups_34537	168.50 +- 39.50	2	0	0	0	0.03 +- 0.02	2	7 PF13377 (2/2) Periplasmic binding protein-like domain PF13185 (2/2) GAF domain PF08448 (2/2) PAS fold PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_33923	103.09 +- 21.09	2	0	0	0	0.06 +- 0.08	2	7 TIGR01496 (2/2) dihydropteroate synthase PF08310 (2/2) LGFP repeat PF07995 (2/2) Glucose / Sorbosone dehydrogenase PF03734 (2/2) L,D-transpeptidase catalytic domain PF00809 (2/2) Pterin binding enzyme PF00801 (2/2) PKD domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_26615	122.27 +- 27.73	2	0	2	0	0.02 +- 0.01	2	6 PF04073 (2/2) Aminoacyl-tRNA editing domain PF01116 (2/2) Fructose-bisphosphate aldolase class-II PF00892 (2/2) EamA-like transporter family PF00464 (2/2) Serine hydroxymethyltransferase PF04151 (1/2) Bacterial pre-peptidase C-terminal domain PF00082 (1/2) Subtilase family
precursor_jaccard_groups_42614	134.38 +- 26.88	2	0	0	0	0.02 +- 0.01	2	5 PF13515 (2/2) Fusaric acid resistance protein-like PF08386 (2/2) TAP-like protein PF01471 (2/2) Putative peptidoglycan binding domain PF00561 (2/2) alpha/beta hydrolase fold PF00931 (1/2) NB-ARC domain
precursor_jaccard_groups_42116	156.96 +- 65.90	2	0	0	0	0.02 +- 0.03	2	4 PF07582 (2/2) AP endonuclease family 2 C terminus PF02894 (2/2) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel
precursor_jaccard_groups_37472	80.77 +- 3.37	2	0	0	0	0.06 +- 0.08	2	8 PF07690 (2/2) Major Facilitator Superfamily PF07158 (2/2) Dicarboxylate carrier protein MatC N-terminus PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02515 (2/2) CoA-transferase family III PF00932 (2/2) Lamin Tail Domain PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_42252	64.13 +- 5.87	2	0	0	0	0.06 +- 0.13	2	8 TIGR00753 (2/2) undecaprenyl-diphosphatase UppP PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF12840 (2/2) Helix-turn-helix domain PF07728 (2/2) AAA domain (dynein-related subfamily) PF03088 (2/2) Strictosidine synthase PF02673 (2/2) Bacitracin resistance protein BacA
precursor_jaccard_groups_16345	224.43 +- 53.86	3	0	0	0	0.03 +- 0.04	3	6 PF07690 (3/3) Major Facilitator Superfamily PF04542 (3/3) Sigma-70 region 2 PF01435 (3/3) Peptidase family M48 PF00775 (3/3) Dioxygenase PF00583 (3/3) Acetyltransferase (GNAT) family PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_26100	189.23 +- 42.98	2	0	0	0	0.02 +- 0.01	2	5 PF13191 (2/2) AAA ATPase domain PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport PF05199 (2/2) GMC oxidoreductase PF00732 (2/2) GMC oxidoreductase PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_9042	4562.99 +- 1627.42	5	0	2	0	0.01 +- 0.03	5	10 PF17914 (5/5) HopA1 effector protein family PF13649 (5/5) Methyltransferase domain PF05193 (5/5) Peptidase M16 inactive domain PF02441 (5/5) Flavoprotein PF00675 (5/5) Insulinase (Peptidase family M16) PF00664 (5/5) ABC transporter transmembrane region PF00296 (5/5) Luciferase-like monooxygenase PF00005 (5/5) ABC transporter PF01527 (4/5) Transposase PF01061 (4/5) ABC-2 type transporter
precursor_jaccard_groups_42508	61.28 +- 3.22	2	0	0	0	0.05 +- 0.03	2	5 PF13193 (2/2) AMP-binding enzyme C-terminal domain PF02386 (2/2) Cation transport protein PF02254 (2/2) TrkA-N domain PF02080 (2/2) TrkA-C domain PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_25436	195.00 +- 0.00	2	0	1	0	0.02 +- 0.00	2	10 TIGR00229 (2/2) PAS domain S-box protein PF17148 (2/2) Domain of unknown function (DUF5117) PF16313 (2/2) Met-zincin PF13581 (2/2) Histidine kinase-like ATPase domain PF13426 (2/2) PAS domain PF13185 (2/2) GAF domain PF08448 (2/2) PAS fold PF07702 (2/2) UTRA domain PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_2566	131.54 +- 3.07	2	0	0	0	0.09 +- 0.06	2	10 TIGR01382 (2/2) intracellular protease, PfpI family PF13823 (2/2) Alcohol dehydrogenase GroES-associated PF09123 (2/2) Domain of unknown function (DUF1931) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07690 (2/2) Major Facilitator Superfamily PF01965 (2/2) DJ-1/PfpI family PF00248 (2/2) Aldo/keto reductase family PF00107 (2/2) Zinc-binding dehydrogenase PF13515 (1/2) Fusaric acid resistance protein-like PF12805 (1/2) FUSC-like inner membrane protein yccS
precursor_jaccard_groups_22912	205.89 +- 16.36	2	0	0	0	0.06 +- 0.11	2	15 TIGR01182 (2/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (2/2) Domain of unknown function (DUF4380) PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13407 (2/2) Periplasmic binding protein domain PF13378 (2/2) Enolase C-terminal domain-like PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07729 (2/2) FCD domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (2/2) Branched-chain amino acid transport system / permease component PF01081 (2/2) KDPG and KHG aldolase PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00107 (2/2) Zinc-binding dehydrogenase PF00005 (2/2) ABC transporter
precursor_jaccard_groups_29429	30.46 +- 5.65	2	0	0	0	0.07 +- 0.12	2	6 PF17853 (2/2) GGDEF-like domain PF14333 (2/2) Domain of unknown function (DUF4389) PF13556 (2/2) PucR C-terminal helix-turn-helix domain PF08448 (2/2) PAS fold PF07228 (2/2) Stage II sporulation protein E (SpoIIE) PF03492 (2/2) SAM dependent carboxyl methyltransferase
precursor_jaccard_groups_11638	1255.97 +- 999.97	4	0	4	0	0.03 +- 0.06	4	33 TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (4/4) amino acid adenylation domain TIGR00976 (4/4) hydrolase CocE/NonD family protein PF16197 (4/4) Ketoacyl-synthetase C-terminal extension PF13193 (4/4) AMP-binding enzyme C-terminal domain PF13187 (4/4) 4Fe-4S dicluster domain PF08659 (4/4) KR domain PF08545 (4/4) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07690 (4/4) Major Facilitator Superfamily PF07228 (4/4) Stage II sporulation protein E (SpoIIE) PF04432 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus PF04422 (4/4) Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02737 (4/4) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family) PF01070 (4/4) FMN-dependent dehydrogenase PF00698 (4/4) Acyl transferase domain PF00668 (4/4) Condensation domain PF00583 (4/4) Acetyltransferase (GNAT) family PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00296 (4/4) Luciferase-like monooxygenase PF00275 (4/4) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00202 (4/4) Aminotransferase class-III PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain PF13459 (3/4) 4Fe-4S single cluster domain PF10589 (3/4) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF09335 (3/4) SNARE associated Golgi protein PF07730 (3/4) Histidine kinase PF01512 (3/4) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00196 (3/4) Bacterial regulatory proteins, luxR family PF00072 (3/4) Response regulator receiver domain
precursor_jaccard_groups_29587	38.91 +- 7.53	2	0	0	0	0.08 +- 0.05	2	4 PF13796 (2/2) Putative sensor PF07730 (2/2) Histidine kinase PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase PF00775 (2/2) Dioxygenase
precursor_jaccard_groups_30588	1029.17 +- 97.50	2	0	2	0	0.01 +- 0.01	2	11 PF12146 (2/2) Serine aminopeptidase, S33 PF10604 (2/2) Polyketide cyclase / dehydrase and lipid transport PF09924 (2/2) Uncharacterised conserved protein (DUF2156) PF08448 (2/2) PAS fold PF07993 (2/2) Male sterility protein PF07690 (2/2) Major Facilitator Superfamily PF03364 (2/2) Polyketide cyclase / dehydrase and lipid transport PF01613 (2/2) Flavin reductase like domain PF00899 (2/2) ThiF family PF00202 (2/2) Aminotransferase class-III PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_11636	167.66 +- 10.77	2	0	0	0	0.06 +- 0.03	2	9 TIGR01187 (2/2) polyamine ABC transporter, ATP-binding protein PF13416 (2/2) Bacterial extracellular solute-binding protein PF08402 (2/2) TOBE domain PF01593 (2/2) Flavin containing amine oxidoreductase PF00848 (2/2) Ring hydroxylating alpha subunit (catalytic domain) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00355 (2/2) Rieske [2Fe-2S] domain PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter
precursor_jaccard_groups_215	32.76 +- 4.10	2	0	0	0	0.06 +- 0.03	2	2 PF08007 (2/2) Cupin superfamily protein PF00248 (2/2) Aldo/keto reductase family
precursor_jaccard_groups_3468	75.88 +- 0.00	2	0	0	2	0.07 +- 0.07	2	14 TIGR02493 (2/2) pyruvate formate-lyase 1-activating enzyme TIGR01828 (2/2) pyruvate, phosphate dikinase TIGR01255 (2/2) formate acetyltransferase PF14325 (2/2) Domain of unknown function (DUF4383) PF13411 (2/2) MerR HTH family regulatory protein PF04055 (2/2) Radical SAM superfamily PF02901 (2/2) Pyruvate formate lyase-like PF02896 (2/2) PEP-utilising enzyme, TIM barrel domain PF02607 (2/2) B12 binding domain PF01326 (2/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01228 (2/2) Glycine radical PF00582 (2/2) Universal stress protein family PF00391 (2/2) PEP-utilising enzyme, mobile domain PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_742	82.30 +- 46.49	40	0	38	40	0.05 +- 0.02	40	3 PF13471 (40/40) Transglutaminase-like superfamily PF05402 (40/40) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (40/40) Asparagine synthase
precursor_jaccard_groups_41550	702.33 +- 200.67	2	0	0	0	0.01 +- 0.00	2	12 TIGR00556 (2/2) phosphopantetheine--protein transferase domain TIGR00027 (2/2) methyltransferase, TIGR00027 family PF12706 (2/2) Beta-lactamase superfamily domain PF11583 (2/2) P-aminobenzoate N-oxygenase AurF PF09947 (2/2) Uncharacterized protein conserved in archaea (DUF2180) PF07690 (2/2) Major Facilitator Superfamily PF06628 (2/2) Catalase-related immune-responsive PF04072 (2/2) Leucine carboxyl methyltransferase PF01648 (2/2) 4'-phosphopantetheinyl transferase superfamily PF01575 (2/2) MaoC like domain PF00550 (2/2) Phosphopantetheine attachment site PF00199 (2/2) Catalase
precursor_jaccard_groups_32091	895.44 +- 308.77	2	0	2	0	0.02 +- 0.03	2	15 TIGR01415 (2/2) pyridoxal-phosphate dependent TrpB-like enzyme PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF06368 (2/2) Methylaspartate mutase E chain (MutE) PF06339 (2/2) Ectoine synthase PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02310 (2/2) B12 binding domain PF01841 (2/2) Transglutaminase-like superfamily PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
precursor_jaccard_groups_14462	144.98 +- 11.02	2	0	0	0	0.09 +- 0.06	2	16 PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region PF07729 (2/2) FCD domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01081 (2/2) KDPG and KHG aldolase PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain PF16499 (1/2) Alpha galactosidase A
precursor_jaccard_groups_1598	57.96 +- 12.04	2	0	0	2	0.05 +- 0.10	2	9 TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family TIGR04268 (2/2) FXSXX-COOH protein TIGR04267 (2/2) HEXXH motif domain PF13676 (2/2) TIR domain PF13424 (2/2) Tetratricopeptide repeat PF13374 (2/2) Tetratricopeptide repeat PF13365 (2/2) Trypsin-like peptidase domain PF07728 (2/2) AAA domain (dynein-related subfamily) PF04055 (2/2) Radical SAM superfamily
precursor_jaccard_groups_41497	154.25 +- 11.20	2	0	2	0	0.05 +- 0.16	2	19 TIGR03026 (2/2) nucleotide sugar dehydrogenase TIGR01733 (2/2) amino acid adenylation domain PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF13535 (2/2) ATP-grasp domain PF13469 (2/2) Sulfotransferase family PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF02615 (2/2) Malate/L-lactate dehydrogenase PF01522 (2/2) Polysaccharide deacetylase PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00984 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00196 (2/2) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_15368	396.47 +- 171.88	3	0	0	0	0.01 +- 0.02	3	12 TIGR01549 (3/3) HAD hydrolase, family IA, variant 1 PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF18130 (3/3) ATP-grasp N-terminal domain PF13535 (3/3) ATP-grasp domain PF13419 (3/3) Haloacid dehalogenase-like hydrolase PF07690 (3/3) Major Facilitator Superfamily PF06245 (3/3) Protein of unknown function (DUF1015) PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01557 (3/3) Fumarylacetoacetate (FAA) hydrolase family PF00291 (3/3) Pyridoxal-phosphate dependent enzyme PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_9130	261.23 +- 64.11	5	0	0	0	0.01 +- 0.01	5	6 PF13459 (5/5) 4Fe-4S single cluster domain PF10589 (5/5) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF08386 (5/5) TAP-like protein PF03640 (5/5) Secreted repeat of unknown function PF01512 (5/5) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00561 (5/5) alpha/beta hydrolase fold
precursor_jaccard_groups_29102	175.06 +- 37.41	2	0	0	0	0.03 +- 0.04	2	9 TIGR00350 (2/2) cell envelope-related function transcriptional attenuator common domain PF13399 (2/2) LytR cell envelope-related transcriptional attenuator PF07859 (2/2) alpha/beta hydrolase fold PF03816 (2/2) Cell envelope-related transcriptional attenuator domain PF03807 (2/2) NADP oxidoreductase coenzyme F420-dependent PF01258 (2/2) Prokaryotic dksA/traR C4-type zinc finger PF00768 (2/2) D-alanyl-D-alanine carboxypeptidase PF00459 (2/2) Inositol monophosphatase family PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
precursor_jaccard_groups_13679	34.39 +- 12.89	2	0	2	0	0.09 +- 0.08	2	2 PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family PF01810 (2/2) LysE type translocator
precursor_jaccard_groups_28294	246.49 +- 143.51	2	0	2	2	0.04 +- 0.15	2	8 PF11259 (2/2) Protein of unknown function (DUF3060) PF04055 (2/2) Radical SAM superfamily PF02518 (2/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF02310 (2/2) B12 binding domain PF01522 (2/2) Polysaccharide deacetylase PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00072 (2/2) Response regulator receiver domain PF00583 (1/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_15412	138.46 +- 43.67	3	0	0	0	0.03 +- 0.02	3	9 PF17291 (3/3) N-terminal domain of M60-like peptidases PF13402 (3/3) Peptidase M60, enhancin and enhancin-like PF13377 (3/3) Periplasmic binding protein-like domain PF10022 (3/3) Uncharacterized protein conserved in bacteria (DUF2264) PF08124 (3/3) Polysaccharide lyase family 8, N terminal alpha-helical domain PF02884 (3/3) Polysaccharide lyase family 8, C-terminal beta-sandwich domain PF02826 (3/3) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02278 (3/3) Polysaccharide lyase family 8, super-sandwich domain PF00356 (3/3) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_3796	885.57 +- 176.07	4	0	1	0	0.01 +- 0.01	4	9 TIGR00710 (4/4) drug resistance transporter, Bcr/CflA subfamily PF07690 (4/4) Major Facilitator Superfamily PF03737 (4/4) Aldolase/RraA PF03466 (4/4) LysR substrate binding domain PF01361 (4/4) Tautomerase enzyme PF00994 (4/4) Probable molybdopterin binding domain PF00682 (4/4) HMGL-like PF00180 (4/4) Isocitrate/isopropylmalate dehydrogenase PF00126 (4/4) Bacterial regulatory helix-turn-helix protein, lysR family
precursor_jaccard_groups_2704	196.89 +- 6.51	4	0	0	0	0.04 +- 0.15	4	16 TIGR01558 (4/4) putative phage terminase, small subunit, P27 family TIGR01554 (4/4) phage major capsid protein, HK97 family TIGR01543 (4/4) phage prohead protease, HK97 family TIGR01537 (4/4) phage portal protein, HK97 family PF16945 (4/4) Putative lactococcus lactis phage r1t holin PF13229 (4/4) Right handed beta helix region PF10145 (4/4) Phage-related minor tail protein PF05119 (4/4) Phage terminase, small subunit PF05065 (4/4) Phage capsid family PF04860 (4/4) Phage portal protein PF04586 (4/4) Caudovirus prohead serine protease PF03354 (4/4) Phage Terminase PF01510 (4/4) N-acetylmuramoyl-L-alanine amidase PF01476 (4/4) LysM domain PF01464 (4/4) Transglycosylase SLT domain PF01381 (4/4) Helix-turn-helix
precursor_jaccard_groups_8499	174.93 +- 114.89	6	0	0	0	0.03 +- 0.05	6	8 PF13577 (6/6) SnoaL-like domain PF13561 (6/6) Enoyl-(Acyl carrier protein) reductase PF12697 (6/6) Alpha/beta hydrolase family PF07690 (6/6) Major Facilitator Superfamily PF04444 (6/6) Catechol dioxygenase N terminus PF01261 (6/6) Xylose isomerase-like TIM barrel PF00775 (6/6) Dioxygenase PF00465 (6/6) Iron-containing alcohol dehydrogenase
precursor_jaccard_groups_43471	151.58 +- 28.42	2	0	0	0	0.02 +- 0.02	2	3 PF13302 (2/2) Acetyltransferase (GNAT) domain PF07690 (2/2) Major Facilitator Superfamily PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme
precursor_jaccard_groups_27320	481.90 +- 168.10	2	0	0	0	0.02 +- 0.02	2	6 PF13377 (2/2) Periplasmic binding protein-like domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_18062	291.05 +- 29.25	2	0	0	0	0.08 +- 0.18	2	21 TIGR01928 (2/2) o-succinylbenzoate synthase TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF17676 (2/2) LD-carboxypeptidase C-terminal domain PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF12831 (2/2) FAD dependent oxidoreductase PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF07883 (2/2) Cupin domain PF07690 (2/2) Major Facilitator Superfamily PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02515 (2/2) CoA-transferase family III PF02016 (2/2) LD-carboxypeptidase N-terminal domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01381 (2/2) Helix-turn-helix PF01380 (2/2) SIS domain PF00701 (2/2) Dihydrodipicolinate synthetase family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00171 (2/2) Aldehyde dehydrogenase family PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1609	46.64 +- 3.06	3	0	0	0	0.06 +- 0.07	3	4 PF07730 (3/3) Histidine kinase PF00196 (3/3) Bacterial regulatory proteins, luxR family PF00072 (3/3) Response regulator receiver domain PF13649 (2/3) Methyltransferase domain
precursor_jaccard_groups_870	104.64 +- 38.90	15	0	0	0	0.06 +- 0.07	15	9 PF14158 (15/15) YndJ-like protein PF13581 (15/15) Histidine kinase-like ATPase domain PF13492 (15/15) GAF domain PF11716 (15/15) Mycothiol maleylpyruvate isomerase N-terminal domain PF09348 (15/15) Domain of unknown function (DUF1990) PF08447 (15/15) PAS fold PF07228 (15/15) Stage II sporulation protein E (SpoIIE) PF03446 (15/15) NAD binding domain of 6-phosphogluconate dehydrogenase PF00149 (15/15) Calcineurin-like phosphoesterase
precursor_jaccard_groups_11307	152.71 +- 40.50	3	0	0	0	0.02 +- 0.01	3	3 PF07690 (3/3) Major Facilitator Superfamily PF01227 (3/3) GTP cyclohydrolase I PF00293 (3/3) NUDIX domain
precursor_jaccard_groups_4943	375.44 +- 131.77	2	0	2	0	0.09 +- 0.21	2	34 TIGR01902 (2/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (2/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01733 (2/2) amino acid adenylation domain TIGR00768 (2/2) alpha-L-glutamate ligase, RimK family PF18603 (2/2) L-amino acid ligase C-terminal domain 2 PF18130 (2/2) ATP-grasp N-terminal domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13602 (2/2) Zinc-binding dehydrogenase PF13535 (2/2) ATP-grasp domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08990 (2/2) Erythronolide synthase docking PF08659 (2/2) KR domain PF08443 (2/2) RimK-like ATP-grasp domain PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF08028 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02779 (2/2) Transketolase, pyrimidine binding domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01370 (2/2) NAD dependent epimerase/dehydratase family PF01118 (2/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00975 (2/2) Thioesterase domain PF00698 (2/2) Acyl transferase domain PF00696 (2/2) Amino acid kinase family PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF00857 (1/2) Isochorismatase family
precursor_jaccard_groups_23563	3120.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	13 TIGR04245 (2/2) N-acyltransferase NodA TIGR04243 (2/2) chitooligosaccharide deacetylase NodB TIGR04242 (2/2) chitooligosaccharide synthase NodC TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02474 (2/2) Nodulation protein A (NodA) PF01522 (2/2) Polysaccharide deacetylase PF01061 (2/2) ABC-2 type transporter PF00535 (2/2) Glycosyl transferase family 2 PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (2/2) ABC transporter
precursor_jaccard_groups_7393	47.52 +- 9.22	3	0	0	0	0.04 +- 0.05	3	3 PF09586 (3/3) Bacterial membrane protein YfhO PF04138 (3/3) GtrA-like protein PF00535 (3/3) Glycosyl transferase family 2
precursor_jaccard_groups_1131	516.00 +- 129.00	2	0	2	2	0.01 +- 0.00	2	5 PF13471 (2/2) Transglutaminase-like superfamily PF00733 (2/2) Asparagine synthase PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00005 (1/2) ABC transporter
precursor_jaccard_groups_26322	7843.20 +- 6508.80	2	0	2	2	0.05 +- 0.15	2	21 TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (2/2) SagB-type dehydrogenase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01891 (2/2) amidohydrolase PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term PF07730 (2/2) Histidine kinase PF04738 (2/2) Lantibiotic dehydratase, N terminus PF03412 (2/2) Peptidase C39 family PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01546 (2/2) Peptidase family M20/M25/M40 PF01061 (2/2) ABC-2 type transporter PF00881 (2/2) Nitroreductase family PF00664 (2/2) ABC transporter transmembrane region PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00072 (2/2) Response regulator receiver domain PF00067 (2/2) Cytochrome P450 PF00005 (2/2) ABC transporter PF14310 (1/2) Fibronectin type III-like domain PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
precursor_jaccard_groups_37336	23.45 +- 0.00	2	0	0	0	0.09 +- 0.07	2	3 PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I PF08241 (2/2) Methyltransferase domain PF00753 (2/2) Metallo-beta-lactamase superfamily
precursor_jaccard_groups_41413	650.00 +- 0.00	2	0	0	0	0.02 +- 0.00	2	6 TIGR01484 (2/2) HAD hydrolase, family IIB PF08282 (2/2) haloacid dehalogenase-like hydrolase PF07690 (2/2) Major Facilitator Superfamily PF01259 (2/2) SAICAR synthetase PF00326 (2/2) Prolyl oligopeptidase family PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_19421	322.50 +- 0.00	2	0	2	0	0.02 +- 0.00	2	6 PF03412 (2/2) Peptidase C39 family PF00668 (2/2) Condensation domain PF00664 (2/2) ABC transporter transmembrane region PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00005 (2/2) ABC transporter
precursor_jaccard_groups_1730	27.06 +- 5.19	2	0	0	0	0.09 +- 0.10	2	7 PF13516 (2/2) Leucine Rich repeat PF13203 (2/2) Putative metallopeptidase domain PF09967 (2/2) VWA-like domain (DUF2201) PF07728 (2/2) AAA domain (dynein-related subfamily) PF14435 (1/2) SUKH-4 immunity protein PF12796 (1/2) Ankyrin repeats (3 copies) PF01738 (1/2) Dienelactone hydrolase family
precursor_jaccard_groups_883	91.17 +- 58.33	18	0	0	0	0.03 +- 0.02	18	3 PF12833 (18/18) Helix-turn-helix domain PF02311 (18/18) AraC-like ligand binding domain PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)
precursor_jaccard_groups_33885	132.91 +- 39.09	2	0	0	0	0.05 +- 0.09	2	7 PF13581 (2/2) Histidine kinase-like ATPase domain PF07690 (2/2) Major Facilitator Superfamily PF07681 (2/2) DoxX PF02515 (2/2) CoA-transferase family III PF01546 (2/2) Peptidase family M20/M25/M40 PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00378 (2/2) Enoyl-CoA hydratase/isomerase
precursor_jaccard_groups_39349	157.71 +- 71.71	2	0	2	0	0.04 +- 0.08	2	9 TIGR01733 (2/2) amino acid adenylation domain PF13193 (2/2) AMP-binding enzyme C-terminal domain PF12146 (2/2) Serine aminopeptidase, S33 PF07690 (2/2) Major Facilitator Superfamily PF01425 (2/2) Amidase PF01042 (2/2) Endoribonuclease L-PSP PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_3728	554.81 +- 177.49	10	0	0	0	0.02 +- 0.02	10	19 TIGR02124 (10/10) hydrogenase expression/formation protein HypE TIGR01891 (10/10) amidohydrolase TIGR00709 (10/10) 2,4-diaminobutyrate 4-transaminase TIGR00143 (10/10) carbamoyltransferase HypF PF17788 (10/10) HypF Kae1-like domain PF13535 (10/10) ATP-grasp domain PF12680 (10/10) SnoaL-like domain PF07690 (10/10) Major Facilitator Superfamily PF07503 (10/10) HypF finger PF05977 (10/10) Transmembrane secretion effector PF02769 (10/10) AIR synthase related protein, C-terminal domain PF01546 (10/10) Peptidase family M20/M25/M40 PF01300 (10/10) Telomere recombination PF00857 (10/10) Isochorismatase family PF00708 (10/10) Acylphosphatase PF00586 (10/10) AIR synthase related protein, N-terminal domain PF00202 (10/10) Aminotransferase class-III PF00155 (10/10) Aminotransferase class I and II PF00583 (9/10) Acetyltransferase (GNAT) family
precursor_jaccard_groups_2220	57.64 +- 2.36	2	0	0	0	0.07 +- 0.09	2	4 PF04203 (2/2) Sortase domain PF04149 (2/2) Domain of unknown function (DUF397) PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00583 (2/2) Acetyltransferase (GNAT) family
precursor_jaccard_groups_21166	1225.09 +- 465.17	3	0	3	3	0.01 +- 0.01	3	9 PF13471 (3/3) Transglutaminase-like superfamily PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (3/3) Asparagine synthase PF00664 (3/3) ABC transporter transmembrane region PF00296 (3/3) Luciferase-like monooxygenase PF00005 (3/3) ABC transporter TIGR04353 (2/3) PqqD family protein, HPr-rel-A system PF13646 (2/3) HEAT repeats PF13411 (2/3) MerR HTH family regulatory protein
precursor_jaccard_groups_23668	230.67 +- 116.00	2	0	0	0	0.02 +- 0.03	2	6 PF07690 (2/2) Major Facilitator Superfamily PF05721 (2/2) Phytanoyl-CoA dioxygenase (PhyH) PF02776 (2/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (2/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF00378 (2/2) Enoyl-CoA hydratase/isomerase PF00205 (2/2) Thiamine pyrophosphate enzyme, central domain
precursor_jaccard_groups_253	355.50 +- 160.50	4	2	2	4	0.03 +- 0.03	2	5 PF05147 (4/4) Lanthionine synthetase C-like protein PF01061 (4/4) ABC-2 type transporter PF00069 (4/4) Protein kinase domain PF00005 (4/4) ABC transporter TIGR01188 (2/4) daunorubicin resistance ABC transporter, ATP-binding protein
precursor_jaccard_groups_91	243.84 +- 133.73	4	0	1	4	0.07 +- 0.08	4	8 TIGR00976 (4/4) hydrolase CocE/NonD family protein PF08530 (4/4) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02129 (4/4) X-Pro dipeptidyl-peptidase (S15 family) PF00664 (4/4) ABC transporter transmembrane region PF00005 (4/4) ABC transporter PF01497 (2/4) Periplasmic binding protein PF01032 (2/4) FecCD transport family
precursor_jaccard_groups_9372	400.13 +- 221.16	3	0	1	0	0.05 +- 0.17	3	26 TIGR02100 (3/3) glycogen debranching enzyme GlgX TIGR01515 (3/3) 1,4-alpha-glucan branching enzyme TIGR00377 (3/3) anti-anti-sigma factor PF18085 (3/3) Maltokinase N-terminal cap domain PF17124 (3/3) ThiJ/PfpI family-like PF13614 (3/3) AAA domain PF13581 (3/3) Histidine kinase-like ATPase domain PF13546 (3/3) DDE superfamily endonuclease PF13466 (3/3) STAS domain PF13460 (3/3) NAD(P)H-binding PF13380 (3/3) CoA binding domain PF11896 (3/3) Domain of unknown function (DUF3416) PF07690 (3/3) Major Facilitator Superfamily PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF07221 (3/3) N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) PF07110 (3/3) EthD domain PF02922 (3/3) Carbohydrate-binding module 48 (Isoamylase N-terminal domain) PF02806 (3/3) Alpha amylase, C-terminal all-beta domain PF02776 (3/3) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (3/3) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF01965 (3/3) DJ-1/PfpI family PF01740 (3/3) STAS domain PF00483 (3/3) Nucleotidyl transferase PF00205 (3/3) Thiamine pyrophosphate enzyme, central domain PF00132 (3/3) Bacterial transferase hexapeptide (six repeats) PF00128 (3/3) Alpha amylase, catalytic domain
precursor_jaccard_groups_26664	1942.50 +- 7.50	2	0	0	0	0.01 +- 0.00	2	12 TIGR01891 (2/2) amidohydrolase TIGR01727 (2/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR00004 (2/2) reactive intermediate/imine deaminase PF08352 (2/2) Oligopeptide/dipeptide transporter, C-terminal region PF05299 (2/2) M61 glycyl aminopeptidase PF01979 (2/2) Amidohydrolase family PF01546 (2/2) Peptidase family M20/M25/M40 PF01042 (2/2) Endoribonuclease L-PSP PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00496 (2/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00266 (2/2) Aminotransferase class-V PF00005 (2/2) ABC transporter
precursor_jaccard_groups_21200	398.33 +- 178.68	3	0	0	0	0.02 +- 0.01	3	8 PF12697 (3/3) Alpha/beta hydrolase family PF11723 (3/3) Homotrimeric ring hydroxylase PF02900 (3/3) Catalytic LigB subunit of aromatic ring-opening dioxygenase PF01546 (3/3) Peptidase family M20/M25/M40 PF00561 (3/3) alpha/beta hydrolase fold PF00355 (3/3) Rieske [2Fe-2S] domain PF00175 (3/3) Oxidoreductase NAD-binding domain PF00111 (3/3) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_32436	476.67 +- 43.33	2	0	0	0	0.01 +- 0.00	2	3 PF18029 (2/2) Glyoxalase-like domain PF07690 (2/2) Major Facilitator Superfamily PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_2686	203.13 +- 221.37	6	0	4	0	0.05 +- 0.10	6	6 PF07992 (6/6) Pyridine nucleotide-disulphide oxidoreductase PF04324 (6/6) BFD-like [2Fe-2S] binding domain PF02782 (6/6) FGGY family of carbohydrate kinases, C-terminal domain PF01266 (6/6) FAD dependent oxidoreductase PF00370 (6/6) FGGY family of carbohydrate kinases, N-terminal domain PF00293 (4/6) NUDIX domain
precursor_jaccard_groups_29077	183.91 +- 13.29	2	0	0	0	0.08 +- 0.06	2	18 PF17801 (2/2) Alpha galactosidase C-terminal beta sandwich domain PF16875 (2/2) Glycosyl hydrolase family 36 N-terminal domain PF16874 (2/2) Glycosyl hydrolase family 36 C-terminal domain PF16499 (2/2) Alpha galactosidase A PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF13378 (2/2) Enolase C-terminal domain-like PF08450 (2/2) SMP-30/Gluconolactonase/LRE-like region PF07729 (2/2) FCD domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01081 (2/2) KDPG and KHG aldolase PF00583 (2/2) Acetyltransferase (GNAT) family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00067 (2/2) Cytochrome P450 PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
precursor_jaccard_groups_24503	73.19 +- 11.76	2	0	2	0	0.08 +- 0.08	2	14 TIGR02965 (2/2) xanthine dehydrogenase, molybdopterin binding subunit TIGR02964 (2/2) xanthine dehydrogenase accessory protein XdhC PF13560 (2/2) Helix-turn-helix domain PF13478 (2/2) XdhC Rossmann domain PF13367 (2/2) PrsW family intramembrane metalloprotease PF13302 (2/2) Acetyltransferase (GNAT) domain PF03450 (2/2) CO dehydrogenase flavoprotein C-terminal domain PF02738 (2/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF02625 (2/2) XdhC and CoxI family PF01799 (2/2) [2Fe-2S] binding domain PF01315 (2/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (2/2) FAD binding domain in molybdopterin dehydrogenase PF00756 (2/2) Putative esterase PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain
precursor_jaccard_groups_17655	877.59 +- 552.41	2	0	0	2	0.02 +- 0.06	2	10 TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component PF17914 (2/2) HopA1 effector protein family PF13469 (2/2) Sulfotransferase family PF03704 (2/2) Bacterial transcriptional activator domain PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01636 (2/2) Phosphotransferase enzyme family PF00664 (2/2) ABC transporter transmembrane region PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter
precursor_jaccard_groups_4347	935.22 +- 296.60	9	0	7	9	0.01 +- 0.00	9	6 TIGR03882 (9/9) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (9/9) SagB-type dehydrogenase domain PF02624 (9/9) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02517 (9/9) CPBP intramembrane metalloprotease PF00881 (9/9) Nitroreductase family PF00296 (9/9) Luciferase-like monooxygenase
precursor_jaccard_groups_3429	1363.95 +- 1630.95	4	0	4	4	0.04 +- 0.08	4	14 TIGR03882 (4/4) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (4/4) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term PF04738 (4/4) Lantibiotic dehydratase, N terminus PF03704 (4/4) Bacterial transcriptional activator domain PF02624 (4/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (4/4) ABC-2 type transporter PF00881 (4/4) Nitroreductase family PF00486 (4/4) Transcriptional regulatory protein, C terminal PF00005 (4/4) ABC transporter TIGR03892 (3/4) thiazolylpeptide-type bacteriocin precursor TIGR01891 (3/4) amidohydrolase PF01546 (3/4) Peptidase family M20/M25/M40 PF00296 (2/4) Luciferase-like monooxygenase
precursor_jaccard_groups_18235	765.63 +- 127.45	2	0	1	0	0.01 +- 0.01	2	8 PF11953 (2/2) Domain of unknown function (DUF3470) PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain PF02597 (2/2) ThiS family PF00501 (2/2) AMP-binding enzyme PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain PF00037 (2/2) 4Fe-4S binding domain PF00550 (1/2) Phosphopantetheine attachment site
precursor_jaccard_groups_21063	650.00 +- 0.00	2	0	0	0	0.01 +- 0.00	2	1 PF13367 (2/2) PrsW family intramembrane metalloprotease
precursor_jaccard_groups_792	680.47 +- 421.39	6	0	3	6	0.05 +- 0.09	6	22 TIGR04364 (6/6) methyltransferase, FxLD system TIGR04363 (6/6) FxLD family lantipeptide TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF05331 (6/6) Protein of unknown function (DUF742) PF05147 (6/6) Lanthionine synthetase C-like protein PF04738 (6/6) Lantibiotic dehydratase, N terminus PF03259 (6/6) Roadblock/LC7 domain PF03029 (6/6) Conserved hypothetical ATP binding protein PF01427 (6/6) D-ala-D-ala dipeptidase PF01135 (6/6) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00293 (6/6) NUDIX domain PF00196 (6/6) Bacterial regulatory proteins, luxR family PF00005 (6/6) ABC transporter PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (5/6) Acyl-CoA dehydrogenase, middle domain PF01590 (5/6) GAF domain PF00441 (5/6) Acyl-CoA dehydrogenase, C-terminal domain PF02518 (4/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00723 (4/6) Glycosyl hydrolases family 15 PF13671 (3/6) AAA domain PF13649 (3/6) Methyltransferase domain
precursor_jaccard_groups_18533	358.87 +- 76.47	3	0	3	0	0.03 +- 0.03	3	16 TIGR03396 (3/3) phospholipase C, phosphocholine-specific TIGR01258 (3/3) phosphoglycerate mutase 1 family TIGR01060 (3/3) phosphopyruvate hydratase PF11575 (3/3) FhuF 2Fe-2S C-terminal domain PF07228 (3/3) Stage II sporulation protein E (SpoIIE) PF05506 (3/3) Domain of unknown function (DUF756) PF04185 (3/3) Phosphoesterase family PF03965 (3/3) Penicillinase repressor PF03952 (3/3) Enolase, N-terminal domain PF03453 (3/3) MoeA N-terminal region (domain I and II) PF01712 (3/3) Deoxynucleoside kinase PF01435 (3/3) Peptidase family M48 PF00994 (3/3) Probable molybdopterin binding domain PF00300 (3/3) Histidine phosphatase superfamily (branch 1) PF00293 (3/3) NUDIX domain PF00113 (3/3) Enolase, C-terminal TIM barrel domain
precursor_jaccard_groups_6734	122.11 +- 15.00	3	0	1	0	0.08 +- 0.21	3	9 PF13191 (3/3) AAA ATPase domain PF10502 (3/3) Signal peptidase, peptidase S26 PF07291 (3/3) Methylamine utilisation protein MauE PF02254 (3/3) TrkA-N domain PF01242 (3/3) 6-pyruvoyl tetrahydropterin synthase PF00717 (3/3) Peptidase S24-like PF00664 (3/3) ABC transporter transmembrane region PF00005 (3/3) ABC transporter PF13181 (2/3) Tetratricopeptide repeat
precursor_jaccard_groups_20649	91.36 +- 15.97	3	0	0	0	0.06 +- 0.11	3	8 PF12450 (3/3) von Willebrand factor PF12034 (3/3) Domain of unknown function (DUF3520) PF10502 (3/3) Signal peptidase, peptidase S26 PF07291 (3/3) Methylamine utilisation protein MauE PF00717 (3/3) Peptidase S24-like PF00501 (3/3) AMP-binding enzyme PF00092 (3/3) von Willebrand factor type A domain PF00005 (3/3) ABC transporter
precursor_jaccard_groups_7647	2698.22 +- 1333.42	6	0	6	6	0.01 +- 0.01	6	9 TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term PF13560 (6/6) Helix-turn-helix domain PF04149 (6/6) Domain of unknown function (DUF397) PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (6/6) Nitroreductase family PF00196 (5/6) Bacterial regulatory proteins, luxR family TIGR03891 (3/6) thiopeptide-type bacteriocin biosynthesis domain
precursor_jaccard_groups_5516	128.12 +- 45.26	4	0	4	0	0.08 +- 0.18	4	20 TIGR04020 (4/4) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (4/4) amino acid adenylation domain PF16197 (4/4) Ketoacyl-synthetase C-terminal extension PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13193 (4/4) AMP-binding enzyme C-terminal domain PF07690 (4/4) Major Facilitator Superfamily PF03067 (4/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02801 (4/4) Beta-ketoacyl synthase, C-terminal domain PF02127 (4/4) Aminopeptidase I zinc metalloprotease (M18) PF00975 (4/4) Thioesterase domain PF00877 (4/4) NlpC/P60 family PF00698 (4/4) Acyl transferase domain PF00668 (4/4) Condensation domain PF00550 (4/4) Phosphopantetheine attachment site PF00501 (4/4) AMP-binding enzyme PF00296 (4/4) Luciferase-like monooxygenase PF00202 (4/4) Aminotransferase class-III PF00109 (4/4) Beta-ketoacyl synthase, N-terminal domain PF12158 (2/4) Protein of unknown function (DUF3592) PF01145 (2/4) SPFH domain / Band 7 family
precursor_jaccard_groups_28413	69.81 +- 25.74	2	0	0	0	0.07 +- 0.06	2	5 PF07690 (2/2) Major Facilitator Superfamily PF05893 (2/2) Acyl-CoA reductase (LuxC) PF04443 (2/2) Acyl-protein synthetase, LuxE PF00583 (2/2) Acetyltransferase (GNAT) family PF00501 (2/2) AMP-binding enzyme
precursor_jaccard_groups_24164	48.84 +- 15.40	2	0	0	0	0.09 +- 0.08	2	8 TIGR00072 (2/2) hydrogenase maturation protease PF17179 (2/2) 4Fe-4S dicluster domain PF10418 (2/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PF01750 (2/2) Hydrogenase maturation protease PF01058 (2/2) NADH ubiquinone oxidoreductase, 20 Kd subunit PF00374 (2/2) Nickel-dependent hydrogenase PF00175 (2/2) Oxidoreductase NAD-binding domain PF00027 (2/2) Cyclic nucleotide-binding domain
precursor_jaccard_groups_670	203.30 +- 256.64	4	0	0	0	0.04 +- 0.05	4	2 TIGR03296 (4/4) M6 family metalloprotease domain PF01070 (2/4) FMN-dependent dehydrogenase
precursor_jaccard_groups_8262	282.51 +- 110.62	6	0	0	0	0.01 +- 0.01	6	5 TIGR02532 (6/6) prepilin-type N-terminal cleavage/methylation domain PF07963 (6/6) Prokaryotic N-terminal methylation motif PF06750 (6/6) Bacterial Peptidase A24 N-terminal domain PF03551 (6/6) Transcriptional regulator PadR-like family PF01478 (6/6) Type IV leader peptidase family
precursor_jaccard_groups_172	318.82 +- 276.51	5	0	2	0	0.05 +- 0.08	5	16 TIGR01525 (5/5) heavy metal translocating P-type ATPase PF04314 (5/5) Copper chaperone PCu(A)C PF00702 (5/5) haloacid dehalogenase-like hydrolase PF00403 (5/5) Heavy-metal-associated domain PF00122 (5/5) E1-E2 ATPase TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family TIGR00802 (4/5) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family PF14237 (4/5) GYF domain 2 PF13421 (4/5) SPFH domain-Band 7 family PF08281 (4/5) Sigma-70, region 4 PF07690 (4/5) Major Facilitator Superfamily PF04542 (4/5) Sigma-70 region 2 PF03824 (4/5) High-affinity nickel-transport protein PF13738 (3/5) Pyridine nucleotide-disulphide oxidoreductase PF01070 (3/5) FMN-dependent dehydrogenase PF00067 (3/5) Cytochrome P450
precursor_jaccard_groups_27768	960.72 +- 458.28	2	0	2	0	0.02 +- 0.02	2	18 PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF14765 (2/2) Polyketide synthase dehydratase PF13191 (2/2) AAA ATPase domain PF08659 (2/2) KR domain PF04820 (2/2) Tryptophan halogenase PF03721 (2/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03704 (2/2) Bacterial transcriptional activator domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01613 (2/2) Flavin reductase like domain PF00999 (2/2) Sodium/hydrogen exchanger family PF00975 (2/2) Thioesterase domain PF00931 (2/2) NB-ARC domain PF00698 (2/2) Acyl transferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00107 (2/2) Zinc-binding dehydrogenase
precursor_jaccard_groups_10899	491.70 +- 429.24	5	0	0	0	0.02 +- 0.05	5	12 TIGR01509 (5/5) HAD hydrolase, family IA, variant 3 TIGR00879 (5/5) MFS transporter, sugar porter (SP) family PF13561 (5/5) Enoyl-(Acyl carrier protein) reductase PF13419 (5/5) Haloacid dehalogenase-like hydrolase PF05199 (5/5) GMC oxidoreductase PF02894 (5/5) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (5/5) Oxidoreductase family, NAD-binding Rossmann fold PF00732 (5/5) GMC oxidoreductase PF00682 (5/5) HMGL-like PF00293 (5/5) NUDIX domain PF00083 (5/5) Sugar (and other) transporter PF01761 (4/5) 3-dehydroquinate synthase
precursor_jaccard_groups_836	687.94 +- 313.54	3	1	2	3	0.02 +- 0.02	2	11 TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term PF05147 (3/3) Lanthionine synthetase C-like protein PF04738 (3/3) Lantibiotic dehydratase, N terminus PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (3/3) Nitroreductase family PF00069 (3/3) Protein kinase domain TIGR03605 (2/3) SagB-type dehydrogenase domain PF00494 (2/3) Squalene/phytoene synthase
precursor_jaccard_groups_380	182.02 +- 102.07	14	0	14	13	0.04 +- 0.05	14	5 TIGR03975 (14/14) ribosomal peptide maturation radical SAM protein 1 PF07690 (14/14) Major Facilitator Superfamily PF02310 (14/14) B12 binding domain PF00326 (14/14) Prolyl oligopeptidase family PF04055 (13/14) Radical SAM superfamily
precursor_jaccard_groups_6961	660.47 +- 112.74	7	0	7	0	0.01 +- 0.01	7	15 TIGR01733 (7/7) amino acid adenylation domain PF18456 (7/7) Diiron non-heme beta-hydroxylase N-terminal domain PF16197 (7/7) Ketoacyl-synthetase C-terminal extension PF13535 (7/7) ATP-grasp domain PF13193 (7/7) AMP-binding enzyme C-terminal domain PF12706 (7/7) Beta-lactamase superfamily domain PF02801 (7/7) Beta-ketoacyl synthase, C-terminal domain PF01636 (7/7) Phosphotransferase enzyme family PF00975 (7/7) Thioesterase domain PF00698 (7/7) Acyl transferase domain PF00668 (7/7) Condensation domain PF00550 (7/7) Phosphopantetheine attachment site PF00501 (7/7) AMP-binding enzyme PF00326 (7/7) Prolyl oligopeptidase family PF00109 (7/7) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_33409	388.00 +- 128.00	2	0	0	0	0.01 +- 0.00	2	6 PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase PF07729 (2/2) FCD domain PF02627 (2/2) Carboxymuconolactone decarboxylase family PF00753 (2/2) Metallo-beta-lactamase superfamily PF00561 (2/2) alpha/beta hydrolase fold PF00392 (2/2) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_27103	143.00 +- 117.00	2	0	0	0	0.04 +- 0.07	2	3 PF09848 (2/2) Uncharacterized conserved protein (DUF2075) PF07728 (2/2) AAA domain (dynein-related subfamily) PF00931 (2/2) NB-ARC domain
precursor_jaccard_groups_43595	101.28 +- 23.28	2	0	0	2	0.05 +- 0.10	2	8 PF13581 (2/2) Histidine kinase-like ATPase domain PF13191 (2/2) AAA ATPase domain PF09346 (2/2) SMI1 / KNR4 family (SUKH-1) PF05147 (2/2) Lanthionine synthetase C-like protein PF00561 (2/2) alpha/beta hydrolase fold PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00005 (2/2) ABC transporter PF04978 (1/2) Protein of unknown function (DUF664)
precursor_jaccard_groups_12176	186.44 +- 101.19	3	0	0	0	0.02 +- 0.02	3	7 PF16353 (3/3) Domain of unknown function(DUF4981) PF13385 (3/3) Concanavalin A-like lectin/glucanases superfamily PF09995 (3/3) Uncharacterized protein conserved in bacteria (DUF2236) PF02929 (3/3) Beta galactosidase small chain PF02837 (3/3) Glycosyl hydrolases family 2, sugar binding domain PF02836 (3/3) Glycosyl hydrolases family 2, TIM barrel domain PF00703 (3/3) Glycosyl hydrolases family 2
precursor_jaccard_groups_40521	50.96 +- 10.96	2	0	0	0	0.06 +- 0.07	2	4 PF11303 (2/2) Protein of unknown function (DUF3105) PF09335 (2/2) SNARE associated Golgi protein PF02388 (2/2) FemAB family PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
precursor_jaccard_groups_19576	215.00 +- 60.81	3	0	3	0	0.01 +- 0.01	3	3 PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain PF00756 (3/3) Putative esterase PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase
precursor_jaccard_groups_44613	91.60 +- 0.33	2	0	2	0	0.10 +- 0.29	2	17 TIGR01733 (2/2) amino acid adenylation domain PF16197 (2/2) Ketoacyl-synthetase C-terminal extension PF13193 (2/2) AMP-binding enzyme C-terminal domain PF07690 (2/2) Major Facilitator Superfamily PF05977 (2/2) Transmembrane secretion effector PF03447 (2/2) Homoserine dehydrogenase, NAD binding domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01842 (2/2) ACT domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00975 (2/2) Thioesterase domain PF00742 (2/2) Homoserine dehydrogenase PF00698 (2/2) Acyl transferase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_44970	250.40 +- 9.60	2	0	0	0	0.02 +- 0.02	2	4 PF13365 (2/2) Trypsin-like peptidase domain PF00400 (2/2) WD domain, G-beta repeat PF00248 (2/2) Aldo/keto reductase family PF07721 (1/2) Tetratricopeptide repeat
precursor_jaccard_groups_3196	79.05 +- 17.93	5	0	0	0	0.08 +- 0.03	5	9 TIGR02133 (5/5) ribose 5-phosphate isomerase PF16896 (5/5) Phosphogluconate dehydrogenase (decarboxylating) C-term PF07690 (5/5) Major Facilitator Superfamily PF03807 (5/5) NADP oxidoreductase coenzyme F420-dependent PF02734 (5/5) DAK2 domain PF02733 (5/5) Dak1 domain PF02502 (5/5) Ribose/Galactose Isomerase PF01261 (5/5) Xylose isomerase-like TIM barrel PF00121 (5/5) Triosephosphate isomerase
precursor_jaccard_groups_39304	376.25 +- 0.00	2	0	0	2	0.03 +- 0.03	2	20 TIGR01656 (2/2) histidinol-phosphate phosphatase domain TIGR01444 (2/2) methyltransferase, FkbM family PF16363 (2/2) GDP-mannose 4,6 dehydratase PF13242 (2/2) HAD-hyrolase-like PF12804 (2/2) MobA-like NTP transferase domain PF12146 (2/2) Serine aminopeptidase, S33 PF05050 (2/2) Methyltransferase FkbM domain PF04055 (2/2) Radical SAM superfamily PF02880 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PF02879 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PF02878 (2/2) Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PF02709 (2/2) N-terminal domain of galactosyltransferase PF01370 (2/2) NAD dependent epimerase/dehydratase family PF01041 (2/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00891 (2/2) O-methyltransferase domain PF00702 (2/2) haloacid dehalogenase-like hydrolase PF00535 (2/2) Glycosyl transferase family 2 PF00408 (2/2) Phosphoglucomutase/phosphomannomutase, C-terminal domain PF00293 (2/2) NUDIX domain PF00037 (2/2) 4Fe-4S binding domain
precursor_jaccard_groups_11860	114.31 +- 18.14	2	0	0	0	0.08 +- 0.04	2	5 PF17831 (2/2) Pyruvate dehydrogenase E1 component middle domain PF13416 (2/2) Bacterial extracellular solute-binding protein PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00456 (2/2) Transketolase, thiamine diphosphate binding domain PF00266 (2/2) Aminotransferase class-V
precursor_jaccard_groups_44856	766.32 +- 13.68	2	0	2	0	0.01 +- 0.00	2	13 TIGR01490 (2/2) HAD hydrolase, family IB PF12710 (2/2) haloacid dehalogenase-like hydrolase PF07690 (2/2) Major Facilitator Superfamily PF03756 (2/2) A-factor biosynthesis hotdog domain PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain PF01494 (2/2) FAD binding domain PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00975 (2/2) Thioesterase domain PF00891 (2/2) O-methyltransferase domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00248 (2/2) Aldo/keto reductase family PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
precursor_jaccard_groups_38287	154.80 +- 0.00	2	0	0	0	0.02 +- 0.01	2	5 TIGR01549 (2/2) HAD hydrolase, family IA, variant 1 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF09130 (2/2) Domain of unknown function (DUF1932) PF02384 (2/2) N-6 DNA Methylase PF01341 (2/2) Glycosyl hydrolases family 6
precursor_jaccard_groups_8003	2401.56 +- 1135.16	3	0	0	0	0.02 +- 0.01	3	13 TIGR01263 (3/3) 4-hydroxyphenylpyruvate dioxygenase PF18603 (3/3) L-amino acid ligase C-terminal domain 2 PF14696 (3/3) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (3/3) ATP-grasp domain PF05721 (3/3) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (3/3) Prephenate dehydrogenase PF01613 (3/3) Flavin reductase like domain PF01070 (3/3) FMN-dependent dehydrogenase PF00903 (3/3) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (3/3) Luciferase-like monooxygenase PF00155 (3/3) Aminotransferase class I and II PF00106 (3/3) short chain dehydrogenase PF18130 (2/3) ATP-grasp N-terminal domain
precursor_jaccard_groups_34641	462.83 +- 311.17	2	0	0	0	0.02 +- 0.04	2	6 PF03704 (2/2) Bacterial transcriptional activator domain PF02615 (2/2) Malate/L-lactate dehydrogenase PF01546 (2/2) Peptidase family M20/M25/M40 PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold PF01261 (2/2) Xylose isomerase-like TIM barrel PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_42264	130.00 +- 70.00	2	0	0	0	0.04 +- 0.03	2	6 PF12833 (2/2) Helix-turn-helix domain PF12625 (2/2) Arabinose-binding domain of AraC transcription regulator, N-term PF02416 (2/2) mttA/Hcf106 family PF00743 (2/2) Flavin-binding monooxygenase-like PF00171 (2/2) Aldehyde dehydrogenase family PF00106 (2/2) short chain dehydrogenase
precursor_jaccard_groups_14078	150.50 +- 136.83	4	0	0	0	0.03 +- 0.02	4	3 PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase PF00067 (4/4) Cytochrome P450 PF03745 (2/4) Domain of unknown function (DUF309)
precursor_jaccard_groups_37594	109.51 +- 1.92	2	0	0	0	0.04 +- 0.03	2	6 PF04167 (2/2) Protein of unknown function (DUF402) PF03992 (2/2) Antibiotic biosynthesis monooxygenase PF02225 (2/2) PA domain PF01978 (2/2) Sugar-specific transcriptional regulator TrmB PF00144 (2/2) Beta-lactamase PF00082 (2/2) Subtilase family
precursor_jaccard_groups_5839	1561.23 +- 946.56	6	0	6	0	0.02 +- 0.07	6	12 PF13622 (6/6) Thioesterase-like superfamily PF07690 (6/6) Major Facilitator Superfamily PF00550 (6/6) Phosphopantetheine attachment site PF00501 (6/6) AMP-binding enzyme PF00487 (6/6) Fatty acid desaturase PF00301 (6/6) Rubredoxin PF00067 (6/6) Cytochrome P450 PF12679 (4/6) ABC-2 family transporter protein PF12146 (4/6) Serine aminopeptidase, S33 PF00005 (4/6) ABC transporter TIGR00711 (3/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF00392 (3/6) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_2272	359.93 +- 257.30	9	0	9	0	0.04 +- 0.07	9	10 TIGR01891 (9/9) amidohydrolase TIGR01821 (9/9) 5-aminolevulinic acid synthase PF16884 (9/9) N-terminal domain of oxidoreductase PF08545 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (9/9) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07690 (9/9) Major Facilitator Superfamily PF02668 (9/9) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (9/9) Peptidase family M20/M25/M40 PF00155 (9/9) Aminotransferase class I and II PF00107 (9/9) Zinc-binding dehydrogenase
precursor_jaccard_groups_5207	964.27 +- 325.73	2	0	0	0	0.01 +- 0.02	2	12 PF10502 (2/2) Signal peptidase, peptidase S26 PF03704 (2/2) Bacterial transcriptional activator domain PF00931 (2/2) NB-ARC domain PF00899 (2/2) ThiF family PF00717 (2/2) Peptidase S24-like PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00005 (2/2) ABC transporter TIGR02227 (1/2) signal peptidase I PF17874 (1/2) MalT-like TPR region PF11271 (1/2) Porin PorA PF07291 (1/2) Methylamine utilisation protein MauE PF00440 (1/2) Bacterial regulatory proteins, tetR family
precursor_jaccard_groups_40	353.21 +- 291.79	2	0	2	0	0.03 +- 0.08	2	15 TIGR01733 (2/2) amino acid adenylation domain TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720 PF13193 (2/2) AMP-binding enzyme C-terminal domain PF03621 (2/2) MbtH-like protein PF00975 (2/2) Thioesterase domain PF00668 (2/2) Condensation domain PF00550 (2/2) Phosphopantetheine attachment site PF00501 (2/2) AMP-binding enzyme PF00155 (2/2) Aminotransferase class I and II TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase PF12680 (1/2) SnoaL-like domain PF08242 (1/2) Methyltransferase domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01070 (1/2) FMN-dependent dehydrogenase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
precursor_jaccard_groups_2073	802.19 +- 237.81	5	3	2	5	0.01 +- 0.00	2	9 TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term PF04738 (5/5) Lantibiotic dehydratase, N terminus PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (5/5) Nitroreductase family TIGR03605 (3/5) SagB-type dehydrogenase domain PF13191 (3/5) AAA ATPase domain PF00196 (3/5) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_4767	234.57 +- 34.56	3	0	0	0	0.01 +- 0.00	3	4 PF07504 (3/3) Fungalysin/Thermolysin Propeptide Motif PF03713 (3/3) Domain of unknown function (DUF305) PF02868 (3/3) Thermolysin metallopeptidase, alpha-helical domain PF01447 (3/3) Thermolysin metallopeptidase, catalytic domain
precursor_jaccard_groups_35789	1105.00 +- 0.00	2	0	0	0	0.02 +- 0.00	2	13 PF16353 (2/2) Domain of unknown function(DUF4981) PF13378 (2/2) Enolase C-terminal domain-like PF13377 (2/2) Periplasmic binding protein-like domain PF06452 (2/2) Carbohydrate family 9 binding domain-like PF02929 (2/2) Beta galactosidase small chain PF02837 (2/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (2/2) Glycosyl hydrolases family 2, TIM barrel domain PF02746 (2/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (2/2) Melibiase PF01547 (2/2) Bacterial extracellular solute-binding protein PF01370 (2/2) NAD dependent epimerase/dehydratase family PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00356 (2/2) Bacterial regulatory proteins, lacI family
precursor_jaccard_groups_16211	260.13 +- 5.78	2	0	0	0	0.02 +- 0.01	2	11 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 TIGR00326 (2/2) riboflavin biosynthesis protein RibD PF13641 (2/2) Glycosyltransferase like family 2 PF12894 (2/2) Anaphase-promoting complex subunit 4 WD40 domain PF07690 (2/2) Major Facilitator Superfamily PF07676 (2/2) WD40-like Beta Propeller Repeat PF02668 (2/2) Taurine catabolism dioxygenase TauD, TfdA family PF01872 (2/2) RibD C-terminal domain PF00925 (2/2) GTP cyclohydrolase II PF00400 (2/2) WD domain, G-beta repeat PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region
precursor_jaccard_groups_584	192.97 +- 127.67	14	0	14	14	0.05 +- 0.03	14	13 TIGR04451 (14/14) lantipeptide, SCO0268 family TIGR03891 (14/14) thiopeptide-type bacteriocin biosynthesis domain PF14028 (14/14) Lantibiotic biosynthesis dehydratase C-term PF05147 (14/14) Lanthionine synthetase C-like protein PF04738 (14/14) Lantibiotic dehydratase, N terminus PF12802 (9/14) MarR family PF12697 (9/14) Alpha/beta hydrolase family PF02065 (9/14) Melibiase PF01547 (9/14) Bacterial extracellular solute-binding protein PF00528 (9/14) Binding-protein-dependent transport system inner membrane component PF00480 (9/14) ROK family PF02894 (8/14) Oxidoreductase family, C-terminal alpha/beta domain PF01408 (8/14) Oxidoreductase family, NAD-binding Rossmann fold
precursor_jaccard_groups_10702	49.71 +- 15.29	2	0	2	2	0.07 +- 0.08	2	6 PF14518 (2/2) Iron-containing redox enzyme PF13191 (2/2) AAA ATPase domain PF13185 (2/2) GAF domain PF04055 (2/2) Radical SAM superfamily PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain PF00082 (2/2) Subtilase family
precursor_jaccard_groups_946	505.07 +- 225.49	23	0	23	23	0.03 +- 0.05	23	6 PF05147 (23/23) Lanthionine synthetase C-like protein PF04672 (23/23) S-adenosyl methyltransferase PF00664 (23/23) ABC transporter transmembrane region PF00326 (23/23) Prolyl oligopeptidase family PF00069 (23/23) Protein kinase domain PF00005 (23/23) ABC transporter
precursor_jaccard_groups_25249	85.00 +- 45.00	2	0	0	0	0.03 +- 0.03	2	2 PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase PF00775 (2/2) Dioxygenase
precursor_jaccard_groups_42565	523.42 +- 54.35	2	0	2	2	0.05 +- 0.08	2	18 TIGR03897 (2/2) type 2 lantibiotic biosynthesis protein LanM TIGR02822 (2/2) zinc-binding alcohol dehydrogenase family protein TIGR00594 (2/2) DNA polymerase III, alpha subunit PF17657 (2/2) Bacterial DNA polymerase III alpha subunit finger domain PF14579 (2/2) Helix-hairpin-helix motif PF13575 (2/2) Domain of unknown function (DUF4135) PF08240 (2/2) Alcohol dehydrogenase GroES-like domain PF07733 (2/2) Bacterial DNA polymerase III alpha NTPase domain PF05147 (2/2) Lanthionine synthetase C-like protein PF03412 (2/2) Peptidase C39 family PF02811 (2/2) PHP domain PF01336 (2/2) OB-fold nucleic acid binding domain PF00664 (2/2) ABC transporter transmembrane region PF00383 (2/2) Cytidine and deoxycytidylate deaminase zinc-binding region PF00107 (2/2) Zinc-binding dehydrogenase PF00005 (2/2) ABC transporter PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF07366 (1/2) SnoaL-like polyketide cyclase
precursor_jaccard_groups_18179	50.96 +- 24.18	3	0	0	0	0.05 +- 0.03	3	3 PF13520 (3/3) Amino acid permease PF00202 (3/3) Aminotransferase class-III PF00171 (3/3) Aldehyde dehydrogenase family
precursor_jaccard_groups_18473	332.14 +- 118.84	3	0	0	0	0.02 +- 0.01	3	3 PF07690 (3/3) Major Facilitator Superfamily PF00884 (3/3) Sulfatase PF12697 (2/3) Alpha/beta hydrolase family
precursor_jaccard_groups_7175	218.17 +- 57.06	5	0	5	5	0.05 +- 0.06	5	9 PF08386 (5/5) TAP-like protein PF05532 (5/5) CsbD-like PF05147 (5/5) Lanthionine synthetase C-like protein PF00664 (5/5) ABC transporter transmembrane region PF00561 (5/5) alpha/beta hydrolase fold PF00069 (5/5) Protein kinase domain PF00005 (5/5) ABC transporter PF12697 (4/5) Alpha/beta hydrolase family PF00117 (3/5) Glutamine amidotransferase class-I
precursor_jaccard_groups_18578	63.35 +- 11.31	3	0	0	0	0.05 +- 0.03	3	4 PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase PF07702 (3/3) UTRA domain PF01925 (3/3) Sulfite exporter TauE/SafE PF00392 (3/3) Bacterial regulatory proteins, gntR family
precursor_jaccard_groups_29183	533.02 +- 31.35	2	0	0	0	0.01 +- 0.00	2	9 TIGR01891 (2/2) amidohydrolase PF14518 (2/2) Iron-containing redox enzyme PF07690 (2/2) Major Facilitator Superfamily PF04204 (2/2) Homoserine O-succinyltransferase PF03704 (2/2) Bacterial transcriptional activator domain PF01546 (2/2) Peptidase family M20/M25/M40 PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme PF00931 (2/2) NB-ARC domain PF00486 (2/2) Transcriptional regulatory protein, C terminal
precursor_jaccard_groups_2398	953.88 +- 214.88	4	0	0	4	0.01 +- 0.01	4	7 TIGR04085 (4/4) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (4/4) Iron-sulfur cluster-binding domain PF05402 (4/4) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (4/4) Radical SAM superfamily PF01061 (4/4) ABC-2 type transporter PF00717 (4/4) Peptidase S24-like PF00005 (4/4) ABC transporter
precursor_jaccard_groups_32647	381.16 +- 102.59	2	0	0	0	0.02 +- 0.02	2	4 PF02225 (2/2) PA domain PF01978 (2/2) Sugar-specific transcriptional regulator TrmB PF00196 (2/2) Bacterial regulatory proteins, luxR family PF00082 (2/2) Subtilase family
precursor_jaccard_groups_21054	324.25 +- 46.50	3	0	3	0	0.01 +- 0.00	3	7 TIGR01746 (3/3) thioester reductase domain PF13193 (3/3) AMP-binding enzyme C-terminal domain PF07993 (3/3) Male sterility protein PF00550 (3/3) Phosphopantetheine attachment site PF00501 (3/3) AMP-binding enzyme PF00300 (3/3) Histidine phosphatase superfamily (branch 1) PF00196 (3/3) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_1683	1303.55 +- 601.09	16	1	15	16	0.02 +- 0.01	15	8 TIGR03898 (16/16) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (16/16) type 2 lantibiotic biosynthesis protein LanM PF13575 (16/16) Domain of unknown function (DUF4135) PF05147 (16/16) Lanthionine synthetase C-like protein PF03412 (16/16) Peptidase C39 family PF00664 (16/16) ABC transporter transmembrane region PF00005 (16/16) ABC transporter PF12679 (14/16) ABC-2 family transporter protein
precursor_jaccard_groups_4506	299.00 +- 23.50	2	0	0	0	0.05 +- 0.09	2	12 TIGR01764 (2/2) DNA binding domain, excisionase family PF13411 (2/2) MerR HTH family regulatory protein PF13245 (2/2) AAA domain PF12728 (2/2) Helix-turn-helix domain PF12697 (2/2) Alpha/beta hydrolase family PF12679 (2/2) ABC-2 family transporter protein PF07739 (2/2) TipAS antibiotic-recognition domain PF03033 (2/2) Glycosyltransferase family 28 N-terminal domain PF01551 (2/2) Peptidase family M23 PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00005 (2/2) ABC transporter PF13673 (1/2) Acetyltransferase (GNAT) domain
precursor_jaccard_groups_2899	191.56 +- 72.66	4	0	0	0	0.07 +- 0.11	4	11 TIGR00711 (4/4) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16859 (4/4) Tetracyclin repressor-like, C-terminal domain PF14224 (4/4) Domain of unknown function (DUF4331) PF08240 (4/4) Alcohol dehydrogenase GroES-like domain PF07690 (4/4) Major Facilitator Superfamily PF00925 (4/4) GTP cyclohydrolase II PF00440 (4/4) Bacterial regulatory proteins, tetR family PF00107 (4/4) Zinc-binding dehydrogenase PF00082 (3/4) Subtilase family PF02882 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PF00763 (2/4) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
precursor_jaccard_groups_45300	516.00 +- 0.00	2	0	2	0	0.01 +- 0.00	2	4 PF10017 (2/2) Histidine-specific methyltransferase, SAM-dependent PF03781 (2/2) Sulfatase-modifying factor enzyme 1 PF02450 (2/2) Lecithin:cholesterol acyltransferase PF00400 (2/2) WD domain, G-beta repeat
precursor_jaccard_groups_28463	24.72 +- 1.08	2	0	0	0	0.08 +- 0.08	2	4 PF10923 (2/2) P-loop Domain of unknown function (DUF2791) PF09848 (2/2) Uncharacterized conserved protein (DUF2075) PF00271 (2/2) Helicase conserved C-terminal domain PF00270 (2/2) DEAD/DEAH box helicase
precursor_jaccard_groups_29296	322.38 +- 56.79	2	0	0	0	0.02 +- 0.02	2	6 PF09339 (2/2) IclR helix-turn-helix domain PF01614 (2/2) Bacterial transcriptional regulator PF00440 (2/2) Bacterial regulatory proteins, tetR family PF00175 (2/2) Oxidoreductase NAD-binding domain PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain PF00067 (2/2) Cytochrome P450
precursor_jaccard_groups_10796	1463.93 +- 1117.75	4	0	0	0	0.02 +- 0.01	4	14 PF18603 (4/4) L-amino acid ligase C-terminal domain 2 PF18130 (4/4) ATP-grasp N-terminal domain PF13561 (4/4) Enoyl-(Acyl carrier protein) reductase PF13535 (4/4) ATP-grasp domain PF13378 (4/4) Enolase C-terminal domain-like PF12146 (4/4) Serine aminopeptidase, S33 PF08241 (4/4) Methyltransferase domain PF07690 (4/4) Major Facilitator Superfamily PF05721 (4/4) Phytanoyl-CoA dioxygenase (PhyH) PF03321 (4/4) GH3 auxin-responsive promoter PF02826 (4/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02746 (4/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF00694 (4/4) Aconitase C-terminal domain PF00330 (4/4) Aconitase family (aconitate hydratase)
precursor_jaccard_groups_24990	139.98 +- 39.33	2	0	0	0	0.04 +- 0.04	2	6 PF07702 (2/2) UTRA domain PF04672 (2/2) S-adenosyl methyltransferase PF03747 (2/2) ADP-ribosylglycohydrolase PF02133 (2/2) Permease for cytosine/purines, uracil, thiamine, allantoin PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase
precursor_jaccard_groups_41969	433.58 +- 275.92	2	0	0	0	0.04 +- 0.03	2	8 TIGR00126 (2/2) deoxyribose-phosphate aldolase PF13407 (2/2) Periplasmic binding protein domain PF07702 (2/2) UTRA domain PF05025 (2/2) RbsD / FucU transport protein family PF02653 (2/2) Branched-chain amino acid transport system / permease component PF00392 (2/2) Bacterial regulatory proteins, gntR family PF00294 (2/2) pfkB family carbohydrate kinase PF00005 (2/2) ABC transporter
precursor_jaccard_groups_124	359.72 +- 141.51	6	0	0	0	0.02 +- 0.04	6	6 PF07739 (6/6) TipAS antibiotic-recognition domain PF07690 (6/6) Major Facilitator Superfamily PF07228 (6/6) Stage II sporulation protein E (SpoIIE) PF00291 (6/6) Pyridoxal-phosphate dependent enzyme PF13411 (5/6) MerR HTH family regulatory protein PF01551 (5/6) Peptidase family M23
precursor_jaccard_groups_27389	961.71 +- 70.29	2	0	2	0	0.01 +- 0.00	2	8 PF10042 (2/2) Uncharacterized conserved protein (DUF2278) PF08386 (2/2) TAP-like protein PF07732 (2/2) Multicopper oxidase PF07731 (2/2) Multicopper oxidase PF07676 (2/2) WD40-like Beta Propeller Repeat PF01979 (2/2) Amidohydrolase family PF00561 (2/2) alpha/beta hydrolase fold PF00394 (2/2) Multicopper oxidase
precursor_jaccard_groups_22400	300.06 +- 213.54	3	0	0	0	0.04 +- 0.05	3	7 PF17900 (3/3) Peptidase M1 N-terminal domain PF02909 (3/3) Tetracyclin repressor-like, C-terminal domain PF02423 (3/3) Ornithine cyclodeaminase/mu-crystallin family PF01965 (3/3) DJ-1/PfpI family PF01433 (3/3) Peptidase family M1 domain PF00440 (3/3) Bacterial regulatory proteins, tetR family PF00082 (3/3) Subtilase family
precursor_jaccard_groups_12706	1070.36 +- 277.93	4	0	0	0	0.02 +- 0.01	4	9 PF17914 (4/4) HopA1 effector protein family PF13649 (4/4) Methyltransferase domain PF12698 (4/4) ABC-2 family transporter protein PF02441 (4/4) Flavoprotein PF01636 (4/4) Phosphotransferase enzyme family PF00664 (4/4) ABC transporter transmembrane region PF00005 (4/4) ABC transporter PF13732 (3/4) Domain of unknown function (DUF4162) PF00196 (3/4) Bacterial regulatory proteins, luxR family
precursor_jaccard_groups_37144	234.00 +- 26.00	2	0	0	0	0.01 +- 0.01	2	6 PF12146 (2/2) Serine aminopeptidase, S33 PF10006 (2/2) Uncharacterized conserved protein (DUF2249) PF09339 (2/2) IclR helix-turn-helix domain PF01979 (2/2) Amidohydrolase family PF01557 (2/2) Fumarylacetoacetate (FAA) hydrolase family PF00899 (2/2) ThiF family
precursor_jaccard_groups_37140	454.25 +- 29.50	2	0	2	2	0.02 +- 0.02	2	13 TIGR00928 (2/2) adenylosuccinate lyase PF13673 (2/2) Acetyltransferase (GNAT) domain PF13454 (2/2) FAD-NAD(P)-binding PF10397 (2/2) Adenylosuccinate lyase C-terminus PF07969 (2/2) Amidohydrolase family PF07690 (2/2) Major Facilitator Superfamily PF05402 (2/2) Coenzyme PQQ synthesis protein D (PqqD) PF03704 (2/2) Bacterial transcriptional activator domain PF01425 (2/2) Amidase PF00931 (2/2) NB-ARC domain PF00486 (2/2) Transcriptional regulatory protein, C terminal PF00206 (2/2) Lyase PF00120 (2/2) Glutamine synthetase, catalytic domain
precursor_jaccard_groups_848	137.11 +- 11.03	4	0	4	4	0.03 +- 0.04	4	3 PF13471 (4/4) Transglutaminase-like superfamily PF13302 (4/4) Acetyltransferase (GNAT) domain PF00733 (4/4) Asparagine synthase
precursor_jaccard_groups_4970	759.98 +- 690.09	3	0	3	3	0.06 +- 0.20	3	6 PF06114 (3/3) IrrE N-terminal-like domain PF05147 (3/3) Lanthionine synthetase C-like protein PF02687 (3/3) FtsX-like permease family PF00082 (3/3) Subtilase family PF00069 (3/3) Protein kinase domain PF00005 (3/3) ABC transporter
precursor_jaccard_groups_34265	118.75 +- 11.25	2	0	0	0	0.08 +- 0.11	2	7 TIGR03860 (2/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF09995 (2/2) Uncharacterized protein conserved in bacteria (DUF2236) PF09084 (2/2) NMT1/THI5 like PF05719 (2/2) Golgi phosphoprotein 3 (GPP34) PF00528 (2/2) Binding-protein-dependent transport system inner membrane component PF00296 (2/2) Luciferase-like monooxygenase PF00005 (2/2) ABC transporter
precursor_jaccard_groups_10247	388.80 +- 1.47	5	0	0	0	0.01 +- 0.00	5	3 PF07690 (5/5) Major Facilitator Superfamily PF01425 (5/5) Amidase PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)
precursor_jaccard_groups_1631	34.67 +- 0.00	2	0	0	0	0.09 +- 0.12	2	5 TIGR00976 (2/2) hydrolase CocE/NonD family protein PF11361 (2/2) Protein of unknown function (DUF3159) PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF01522 (2/2) Polysaccharide deacetylase
precursor_jaccard_groups_3153	108.35 +- 37.40	3	0	1	0	0.09 +- 0.06	3	5 PF13411 (3/3) MerR HTH family regulatory protein PF03476 (3/3) MOSC N-terminal beta barrel domain PF03473 (3/3) MOSC domain PF01551 (3/3) Peptidase family M23 PF00248 (3/3) Aldo/keto reductase family

Entry name

Average score

Number of operons

Number of MIBiG operons

Number of operons with antismash overlap

Nr of operons with known RiPP domains

Average COG score

Nr of operons passed filter

Common domains

precursor_jaccard_groups_37731

1554.00 +- 6.00

0.01 +- 0.00

precursor_jaccard_groups_9969

409.86 +- 183.82

0.02 +- 0.01

precursor_jaccard_groups_1147

339.13 +- 0.00

0.03 +- 0.01

precursor_jaccard_groups_1146

328.63 +- 21.56

0.03 +- 0.03

PF13471 (3/3) Transglutaminase-like superfamily
PF01546 (3/3) Peptidase family M20/M25/M40
PF00733 (3/3) Asparagine synthase
PF00005 (3/3) ABC transporter

precursor_jaccard_groups_26551

258.09 +- 86.03

0.03 +- 0.05

precursor_jaccard_groups_22017

275.37 +- 49.63

0.02 +- 0.02

precursor_jaccard_groups_41746

135.53 +- 39.47

0.06 +- 0.09

precursor_jaccard_groups_13838

595.57 +- 149.62

0.01 +- 0.00

precursor_jaccard_groups_33956

134.01 +- 78.72

0.06 +- 0.05

precursor_jaccard_groups_19591

172.00 +- 60.81

0.01 +- 0.00

PF08240 (3/3) Alcohol dehydrogenase GroES-like domain
PF00107 (3/3) Zinc-binding dehydrogenase

precursor_jaccard_groups_21824

303.16 +- 34.84

0.06 +- 0.10

precursor_jaccard_groups_10625

502.26 +- 347.48

0.05 +- 0.18

precursor_jaccard_groups_541

144.49 +- 22.80

0.02 +- 0.02

PF07690 (12/12) Major Facilitator Superfamily
PF04055 (12/12) Radical SAM superfamily
PF02897 (12/12) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (12/12) Prolyl oligopeptidase family

precursor_jaccard_groups_2197

1001.47 +- 887.78

0.05 +- 0.18

precursor_jaccard_groups_3842

1010.92 +- 468.30

0.03 +- 0.04

precursor_jaccard_groups_21306

100.33 +- 20.27

0.02 +- 0.02

PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF08924 (3/3) Domain of unknown function (DUF1906)
PF00501 (3/3) AMP-binding enzyme

precursor_jaccard_groups_10192

140.89 +- 0.00

0.10 +- 0.08

precursor_jaccard_groups_44567

117.34 +- 48.52

0.03 +- 0.04

PF07883 (2/2) Cupin domain
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (2/2) Acetyltransferase (GNAT) family

precursor_jaccard_groups_6296

122.10 +- 43.38

0.05 +- 0.04

precursor_jaccard_groups_30675

259.00 +- 1.00

0.01 +- 0.00

PF07859 (2/2) alpha/beta hydrolase fold
PF00175 (2/2) Oxidoreductase NAD-binding domain
PF00111 (2/2) 2Fe-2S iron-sulfur cluster binding domain

precursor_jaccard_groups_30676

777.00 +- 3.00

0.01 +- 0.00

precursor_jaccard_groups_18596

377.27 +- 142.73

0.02 +- 0.01

precursor_jaccard_groups_18227

763.96 +- 609.16

0.05 +- 0.14

precursor_jaccard_groups_35157

77.60 +- 25.60

0.03 +- 0.02

precursor_jaccard_groups_5311

552.84 +- 40.56

0.07 +- 0.18

TIGR03945 (2/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01830 (2/2) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (2/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (2/2) Domain of unknown function (DUF4162)
PF13561 (2/2) Enoyl-(Acyl carrier protein) reductase
PF13279 (2/2) Thioesterase-like superfamily
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF13160 (2/2) Protein of unknown function (DUF3995)
PF12146 (2/2) Serine aminopeptidase, S33
PF07977 (2/2) FabA-like domain
PF06368 (2/2) Methylaspartate mutase E chain (MutE)
PF03621 (2/2) MbtH-like protein
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF02423 (2/2) Ornithine cyclodeaminase/mu-crystallin family
PF02310 (2/2) B12 binding domain
PF01323 (2/2) DSBA-like thioredoxin domain
PF01061 (2/2) ABC-2 type transporter
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00291 (2/2) Pyridoxal-phosphate dependent enzyme
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (2/2) ABC transporter
PF00067 (1/2) Cytochrome P450

precursor_jaccard_groups_269

297.75 +- 125.22

0.02 +- 0.03

precursor_jaccard_groups_783

148.42 +- 88.47

0.03 +- 0.02

PF13649 (10/10) Methyltransferase domain
PF07690 (10/10) Major Facilitator Superfamily
PF04055 (10/10) Radical SAM superfamily

precursor_jaccard_groups_26178

773.17 +- 20.67

0.01 +- 0.00

precursor_jaccard_groups_464

1062.51 +- 1018.52

0.03 +- 0.09

TIGR03897 (45/46) type 2 lantibiotic biosynthesis protein LanM
PF13575 (45/46) Domain of unknown function (DUF4135)
PF05147 (45/46) Lanthionine synthetase C-like protein
PF03412 (45/46) Peptidase C39 family
PF00664 (45/46) ABC transporter transmembrane region
PF00005 (45/46) ABC transporter
PF14867 (41/46) Lantibiotic alpha

precursor_jaccard_groups_6724

593.52 +- 220.55

0.02 +- 0.04

precursor_jaccard_groups_19927

240.43 +- 106.11

0.01 +- 0.02

TIGR01415 (3/3) pyridoxal-phosphate dependent TrpB-like enzyme
PF01266 (3/3) FAD dependent oxidoreductase
PF01019 (3/3) Gamma-glutamyltranspeptidase
PF00291 (3/3) Pyridoxal-phosphate dependent enzyme

precursor_jaccard_groups_10697

52.65 +- 10.40

0.06 +- 0.07

PF13460 (3/3) NAD(P)H-binding
PF08592 (3/3) Domain of unknown function (DUF1772)
PF01814 (3/3) Hemerythrin HHE cation binding domain
PF12852 (2/3) Cupin
PF12833 (2/3) Helix-turn-helix domain

precursor_jaccard_groups_2900

258.67 +- 0.94

0.01 +- 0.00

PF01757 (3/3) Acyltransferase family
PF00248 (3/3) Aldo/keto reductase family

precursor_jaccard_groups_14447

32.13 +- 5.78

0.06 +- 0.11

precursor_jaccard_groups_38006

362.00 +- 154.00

0.01 +- 0.01

PF08291 (2/2) Peptidase M15
PF01471 (2/2) Putative peptidoglycan binding domain

precursor_jaccard_groups_20439

197.39 +- 31.14

0.07 +- 0.11

precursor_jaccard_groups_17446

249.70 +- 143.29

0.05 +- 0.05

precursor_jaccard_groups_1560

323.00 +- 111.43

0.01 +- 0.00

precursor_jaccard_groups_27278

518.00 +- 2.00

0.01 +- 0.00

PF03412 (2/2) Peptidase C39 family
PF00668 (2/2) Condensation domain
PF00664 (2/2) ABC transporter transmembrane region
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00005 (2/2) ABC transporter

precursor_jaccard_groups_1568

143.45 +- 42.27

0.03 +- 0.04

PF13649 (2/2) Methyltransferase domain
PF13450 (2/2) NAD(P)-binding Rossmann-like domain
PF12697 (2/2) Alpha/beta hydrolase family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF09339 (1/2) IclR helix-turn-helix domain
PF07730 (1/2) Histidine kinase
PF01636 (1/2) Phosphotransferase enzyme family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain

precursor_jaccard_groups_17965

287.08 +- 232.92

0.04 +- 0.10

precursor_jaccard_groups_13164

98.93 +- 27.86

0.05 +- 0.05

precursor_jaccard_groups_13300

237.00 +- 29.70

0.01 +- 0.00

precursor_jaccard_groups_2765

106.36 +- 66.97

0.03 +- 0.06

PF03965 (2/2) Penicillinase repressor
PF01435 (2/2) Peptidase family M48
PF00403 (2/2) Heavy-metal-associated domain
PF12229 (1/2) Putative peptidoglycan binding domain
PF04294 (1/2) VanW like protein
PF00877 (1/2) NlpC/P60 family

precursor_jaccard_groups_7819

34.94 +- 12.33

0.07 +- 0.06

PF13673 (2/2) Acetyltransferase (GNAT) domain
PF01872 (2/2) RibD C-terminal domain

precursor_jaccard_groups_1063

86.80 +- 20.88

0.05 +- 0.06

PF14534 (3/3) Domain of unknown function (DUF4440)
PF08002 (3/3) Protein of unknown function (DUF1697)
PF05922 (3/3) Peptidase inhibitor I9
PF00082 (3/3) Subtilase family
PF01323 (2/3) DSBA-like thioredoxin domain

precursor_jaccard_groups_7953

169.73 +- 174.91

0.05 +- 0.09

precursor_jaccard_groups_40887

195.60 +- 94.65

0.02 +- 0.02

precursor_jaccard_groups_34827

96.37 +- 5.37

0.03 +- 0.04

PF13480 (2/2) Acetyltransferase (GNAT) domain
PF02156 (2/2) Glycosyl hydrolase family 26
PF01522 (2/2) Polysaccharide deacetylase
PF00535 (2/2) Glycosyl transferase family 2

precursor_jaccard_groups_36680

121.07 +- 15.52

0.03 +- 0.05

precursor_jaccard_groups_10178

277.22 +- 74.60

0.08 +- 0.08

precursor_jaccard_groups_10170

153.06 +- 34.46

0.06 +- 0.13

precursor_jaccard_groups_10172

618.09 +- 123.82

0.01 +- 0.02

precursor_jaccard_groups_38688

1632.40 +- 187.60

0.01 +- 0.00

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
TIGR03604 (2/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (2/2) Winged helix DNA-binding domain
PF13191 (2/2) AAA ATPase domain
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF03704 (2/2) Bacterial transcriptional activator domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (2/2) ABC-2 type transporter
PF00881 (2/2) Nitroreductase family
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00005 (2/2) ABC transporter

precursor_jaccard_groups_3368

87.16 +- 4.60

0.09 +- 0.18

precursor_jaccard_groups_4194

48.47 +- 11.07

0.07 +- 0.10

precursor_jaccard_groups_40812

226.50 +- 31.50

0.01 +- 0.00

PF10137 (2/2) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (2/2) Streptomyces sporulation and cell division protein, SsgA
PF00294 (2/2) pfkB family carbohydrate kinase

precursor_jaccard_groups_12889

179.53 +- 21.38

0.08 +- 0.15

precursor_jaccard_groups_16101

609.27 +- 165.86

0.01 +- 0.00

precursor_jaccard_groups_2230

61.10 +- 12.21

0.05 +- 0.02

PF01292 (3/3) Prokaryotic cytochrome b561
PF00174 (3/3) Oxidoreductase molybdopterin binding domain
PF07519 (2/3) Tannase and feruloyl esterase

precursor_jaccard_groups_1111

544.45 +- 297.46

0.02 +- 0.02

PF17914 (29/29) HopA1 effector protein family
PF05193 (29/29) Peptidase M16 inactive domain
PF02441 (29/29) Flavoprotein
PF00675 (29/29) Insulinase (Peptidase family M16)
PF13649 (28/29) Methyltransferase domain
PF00296 (24/29) Luciferase-like monooxygenase
PF00005 (22/29) ABC transporter

precursor_jaccard_groups_19369

1018.46 +- 114.56

0.01 +- 0.00

precursor_jaccard_groups_4810

2158.41 +- 761.00

0.01 +- 0.01

precursor_jaccard_groups_44133

182.05 +- 34.62

0.02 +- 0.02

precursor_jaccard_groups_33095

69.96 +- 24.43

0.05 +- 0.09

TIGR04269 (2/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (2/2) FXSXX-COOH protein
TIGR04267 (2/2) HEXXH motif domain
PF13676 (2/2) TIR domain
PF13424 (2/2) Tetratricopeptide repeat
PF13374 (2/2) Tetratricopeptide repeat
PF13365 (2/2) Trypsin-like peptidase domain
PF12680 (2/2) SnoaL-like domain
PF04055 (2/2) Radical SAM superfamily
PF01361 (2/2) Tautomerase enzyme
PF00931 (2/2) NB-ARC domain

precursor_jaccard_groups_29992

705.83 +- 204.17

0.01 +- 0.01

precursor_jaccard_groups_3064

117.96 +- 49.34

0.03 +- 0.02

PF14759 (4/4) Reductase C-terminal
PF07992 (4/4) Pyridine nucleotide-disulphide oxidoreductase
PF14016 (3/4) Protein of unknown function (DUF4232)
PF13370 (3/4) 4Fe-4S single cluster domain of Ferredoxin I
PF01557 (3/4) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (3/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_jaccard_groups_15901

365.31 +- 284.69

0.03 +- 0.05

PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00246 (2/2) Zinc carboxypeptidase

precursor_jaccard_groups_26167

516.00 +- 258.00

0.02 +- 0.03

PF03372 (2/2) Endonuclease/Exonuclease/phosphatase family
PF02557 (2/2) D-alanyl-D-alanine carboxypeptidase
PF00248 (2/2) Aldo/keto reductase family

precursor_jaccard_groups_340

1775.87 +- 1261.12

0.04 +- 0.14

precursor_jaccard_groups_343

285.64 +- 129.72

0.07 +- 0.14

TIGR03945 (9/9) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (9/9) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (9/9) amino acid adenylation domain
TIGR01720 (9/9) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (9/9) daunorubicin resistance ABC transporter, ATP-binding protein
PF13193 (9/9) AMP-binding enzyme C-terminal domain
PF03621 (9/9) MbtH-like protein
PF02423 (9/9) Ornithine cyclodeaminase/mu-crystallin family
PF01061 (9/9) ABC-2 type transporter
PF00975 (9/9) Thioesterase domain
PF00668 (9/9) Condensation domain
PF00550 (9/9) Phosphopantetheine attachment site
PF00501 (9/9) AMP-binding enzyme
PF00291 (9/9) Pyridoxal-phosphate dependent enzyme
PF00005 (9/9) ABC transporter
PF13732 (7/9) Domain of unknown function (DUF4162)

precursor_jaccard_groups_20740

445.71 +- 74.29

0.01 +- 0.00

precursor_jaccard_groups_9015

394.50 +- 74.31

0.02 +- 0.03

precursor_jaccard_groups_7544

187.56 +- 79.93

0.03 +- 0.04

precursor_jaccard_groups_21

40.24 +- 11.75

0.08 +- 0.17

TIGR03296 (3/3) M6 family metalloprotease domain
PF09339 (3/3) IclR helix-turn-helix domain
PF03777 (3/3) ChpA-C

precursor_jaccard_groups_2928

239.85 +- 35.57

0.01 +- 0.00

PF13545 (9/9) Crp-like helix-turn-helix domain
PF07228 (9/9) Stage II sporulation protein E (SpoIIE)
PF00027 (9/9) Cyclic nucleotide-binding domain

precursor_jaccard_groups_29694

45.39 +- 2.39

0.04 +- 0.04

precursor_jaccard_groups_35370

52.32 +- 21.97

0.05 +- 0.02

PF03992 (2/2) Antibiotic biosynthesis monooxygenase
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase

precursor_jaccard_groups_7068

800.06 +- 256.65

0.01 +- 0.01

precursor_jaccard_groups_16192

325.00 +- 239.00

0.03 +- 0.08

PF03067 (3/3) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (3/3) SPFH domain / Band 7 family
PF00877 (3/3) NlpC/P60 family

precursor_jaccard_groups_240

27.25 +- 2.74

0.07 +- 0.09

precursor_jaccard_groups_9715

148.40 +- 67.91

0.02 +- 0.02

PF08386 (5/5) TAP-like protein
PF07228 (5/5) Stage II sporulation protein E (SpoIIE)
PF00561 (5/5) alpha/beta hydrolase fold

precursor_jaccard_groups_480

423.60 +- 111.96

0.05 +- 0.16

precursor_jaccard_groups_13410

1556.00 +- 516.03

0.01 +- 0.00

precursor_jaccard_groups_28573

647.50 +- 2.50

0.01 +- 0.00

precursor_jaccard_groups_15301

344.00 +- 86.00

0.01 +- 0.01

precursor_jaccard_groups_2331

229.23 +- 30.77

0.01 +- 0.01

PF03412 (2/2) Peptidase C39 family
PF00664 (2/2) ABC transporter transmembrane region
PF00535 (2/2) Glycosyl transferase family 2
PF00005 (2/2) ABC transporter
PF13592 (1/2) Winged helix-turn helix
PF13384 (1/2) Homeodomain-like domain
PF13358 (1/2) DDE superfamily endonuclease

precursor_jaccard_groups_9155

1991.35 +- 896.21

0.02 +- 0.10

precursor_jaccard_groups_41971

390.00 +- 0.00

0.01 +- 0.00

precursor_jaccard_groups_45631

216.00 +- 44.00

0.01 +- 0.00

PF13229 (2/2) Right handed beta helix region
PF02826 (2/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02018 (2/2) Carbohydrate binding domain

precursor_jaccard_groups_1529

4393.65 +- 2025.62

0.02 +- 0.07

TIGR03882 (13/13) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (13/13) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (13/13) Lantibiotic biosynthesis dehydratase C-term
PF02624 (13/13) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (13/13) Nitroreductase family
PF00005 (13/13) ABC transporter
PF05402 (10/13) Coenzyme PQQ synthesis protein D (PqqD)
PF12698 (7/13) ABC-2 family transporter protein

precursor_jaccard_groups_11329

63.45 +- 1.05

0.06 +- 0.06

precursor_jaccard_groups_38131

194.50 +- 52.12

0.07 +- 0.08

precursor_jaccard_groups_22415

778.00 +- 2.83

0.01 +- 0.00

precursor_jaccard_groups_8277

59.27 +- 22.81

0.04 +- 0.07

precursor_jaccard_groups_29303

93.44 +- 9.76

0.04 +- 0.07

precursor_jaccard_groups_45654

129.50 +- 0.50

0.02 +- 0.00

precursor_jaccard_groups_4962

94.90 +- 28.28

0.04 +- 0.02

precursor_jaccard_groups_3243

280.13 +- 235.87

0.05 +- 0.16

precursor_jaccard_groups_14805

27.10 +- 6.92

0.08 +- 0.07

TIGR01249 (3/3) prolyl aminopeptidase
PF07470 (3/3) Glycosyl Hydrolase Family 88
PF00561 (3/3) alpha/beta hydrolase fold

precursor_jaccard_groups_3576

122.11 +- 96.49

0.03 +- 0.04

precursor_jaccard_groups_7966

864.29 +- 155.78

0.01 +- 0.02

precursor_jaccard_groups_40595

209.46 +- 92.46

0.08 +- 0.08

TIGR01234 (2/2) ribulokinase
PF18029 (2/2) Glyoxalase-like domain
PF14200 (2/2) Ricin-type beta-trefoil lectin domain-like
PF11762 (2/2) L-arabinose isomerase C-terminal domain
PF06964 (2/2) Alpha-L-arabinofuranosidase C-terminal domain
PF02782 (2/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02610 (2/2) L-arabinose isomerase
PF01547 (2/2) Bacterial extracellular solute-binding protein
PF00596 (2/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00370 (2/2) FGGY family of carbohydrate kinases, N-terminal domain

precursor_jaccard_groups_10347

447.82 +- 139.46

0.06 +- 0.21

precursor_jaccard_groups_44899

216.17 +- 107.83

0.04 +- 0.05

precursor_jaccard_groups_2207

839.58 +- 460.42

0.02 +- 0.02

TIGR03891 (4/4) thiopeptide-type bacteriocin biosynthesis domain
TIGR03731 (4/4) lantibiotic, gallidermin/nisin family
PF14028 (4/4) Lantibiotic biosynthesis dehydratase C-term
PF05147 (4/4) Lanthionine synthetase C-like protein
PF04738 (4/4) Lantibiotic dehydratase, N terminus
PF01061 (4/4) ABC-2 type transporter
PF00005 (4/4) ABC transporter
PF02052 (3/4) Gallidermin
TIGR02937 (2/4) RNA polymerase sigma factor, sigma-70 family
PF10709 (2/4) Protein of unknown function (DUF2511)
PF08281 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2
PF04072 (2/4) Leucine carboxyl methyltransferase

precursor_jaccard_groups_10572

1767.52 +- 216.09

0.01 +- 0.02

precursor_jaccard_groups_8284

116.33 +- 25.07

0.04 +- 0.04

TIGR04539 (6/6) tRNA-dependent cyclodipeptide synthase
PF16715 (6/6) Cyclodipeptide synthase
PF00881 (6/6) Nitroreductase family
PF00089 (6/6) Trypsin

precursor_jaccard_groups_18924

419.05 +- 139.95

0.01 +- 0.00

precursor_jaccard_groups_5444

780.00 +- 260.00

0.01 +- 0.00

PF07690 (6/6) Major Facilitator Superfamily
PF04055 (6/6) Radical SAM superfamily
PF02441 (6/6) Flavoprotein
PF02310 (3/6) B12 binding domain

precursor_jaccard_groups_5448

206.28 +- 77.96

0.09 +- 0.09

precursor_jaccard_groups_5722

32.06 +- 9.93

0.07 +- 0.05

precursor_jaccard_groups_570

247.62 +- 143.54

0.02 +- 0.03

precursor_jaccard_groups_37299

1068.75 +- 101.25

0.01 +- 0.00

precursor_jaccard_groups_30800

146.32 +- 79.43

0.04 +- 0.06

precursor_jaccard_groups_4143

91.00 +- 39.00

0.03 +- 0.02

PF03130 (2/2) PBS lyase HEAT-like repeat
PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase

precursor_jaccard_groups_4145

444.94 +- 356.18

0.03 +- 0.04

precursor_jaccard_groups_29710

291.55 +- 224.45

0.03 +- 0.06

PF03446 (2/2) NAD binding domain of 6-phosphogluconate dehydrogenase

precursor_jaccard_groups_30662

582.00 +- 192.00

0.01 +- 0.01

precursor_jaccard_groups_26287

105.74 +- 24.26

0.03 +- 0.03

PF07690 (2/2) Major Facilitator Superfamily
PF01255 (2/2) Putative undecaprenyl diphosphate synthase
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme

precursor_jaccard_groups_44459

344.00 +- 0.00

0.03 +- 0.02

precursor_jaccard_groups_888

622.49 +- 466.04

0.07 +- 0.11

TIGR01733 (22/22) amino acid adenylation domain
TIGR01525 (22/22) heavy metal translocating P-type ATPase
PF13193 (22/22) AMP-binding enzyme C-terminal domain
PF10862 (22/22) FcoT-like thioesterase domain
PF08545 (22/22) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (22/22) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (22/22) Male sterility protein
PF07690 (22/22) Major Facilitator Superfamily
PF05118 (22/22) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (22/22) Copper chaperone PCu(A)C
PF02668 (22/22) Taurine catabolism dioxygenase TauD, TfdA family
PF00702 (22/22) haloacid dehalogenase-like hydrolase
PF00668 (22/22) Condensation domain
PF00550 (22/22) Phosphopantetheine attachment site
PF00501 (22/22) AMP-binding enzyme
PF00403 (22/22) Heavy-metal-associated domain
PF00122 (22/22) E1-E2 ATPase
TIGR01746 (21/22) thioester reductase domain
TIGR00747 (21/22) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF01497 (20/22) Periplasmic binding protein
PF01032 (20/22) FecCD transport family
PF00005 (20/22) ABC transporter
PF01965 (19/22) DJ-1/PfpI family
TIGR02937 (11/22) RNA polymerase sigma factor, sigma-70 family
PF08281 (11/22) Sigma-70, region 4
PF04542 (11/22) Sigma-70 region 2
PF03929 (11/22) PepSY-associated TM region

precursor_jaccard_groups_20631

516.00 +- 0.00

0.01 +- 0.00

precursor_jaccard_groups_7757

782.11 +- 340.79

0.01 +- 0.01

precursor_jaccard_groups_31899

129.86 +- 93.00

0.05 +- 0.10

PF03483 (2/2) B3/4 domain
PF01810 (2/2) LysE type translocator
PF00300 (2/2) Histidine phosphatase superfamily (branch 1)

precursor_jaccard_groups_7758

137.60 +- 68.80

0.06 +- 0.05

precursor_jaccard_groups_28707

516.88 +- 343.12

0.04 +- 0.11

precursor_jaccard_groups_477

128.69 +- 4.34

0.09 +- 0.07

PF14310 (2/2) Fibronectin type III-like domain
PF13802 (2/2) Galactose mutarotase-like
PF13377 (2/2) Periplasmic binding protein-like domain
PF03422 (2/2) Carbohydrate binding module (family 6)
PF01915 (2/2) Glycosyl hydrolase family 3 C-terminal domain
PF01055 (2/2) Glycosyl hydrolases family 31
PF00933 (2/2) Glycosyl hydrolase family 3 N terminal domain
PF00528 (2/2) Binding-protein-dependent transport system inner membrane component
PF00356 (2/2) Bacterial regulatory proteins, lacI family
TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF07690 (1/2) Major Facilitator Superfamily
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF01547 (1/2) Bacterial extracellular solute-binding protein

precursor_jaccard_groups_6694

806.75 +- 193.00

0.05 +- 0.17

TIGR04364 (2/2) methyltransferase, FxLD system
TIGR04363 (2/2) FxLD family lantipeptide
TIGR03891 (2/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (2/2) Lantibiotic biosynthesis dehydratase C-term
PF13581 (2/2) Histidine kinase-like ATPase domain
PF05331 (2/2) Protein of unknown function (DUF742)
PF05147 (2/2) Lanthionine synthetase C-like protein
PF04851 (2/2) Type III restriction enzyme, res subunit
PF04738 (2/2) Lantibiotic dehydratase, N terminus
PF04672 (2/2) S-adenosyl methyltransferase
PF03457 (2/2) Helicase associated domain
PF03259 (2/2) Roadblock/LC7 domain
PF03029 (2/2) Conserved hypothetical ATP binding protein
PF02771 (2/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/2) Acyl-CoA dehydrogenase, middle domain
PF01636 (2/2) Phosphotransferase enzyme family
PF01590 (2/2) GAF domain
PF01135 (2/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00441 (2/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (2/2) NUDIX domain
PF00271 (2/2) Helicase conserved C-terminal domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00005 (2/2) ABC transporter
PF13649 (1/2) Methyltransferase domain
PF08241 (1/2) Methyltransferase domain
PF00872 (1/2) Transposase, Mutator family

precursor_jaccard_groups_37668

328.15 +- 104.38

0.07 +- 0.16

precursor_jaccard_groups_22685

738.11 +- 238.15

0.01 +- 0.01

precursor_jaccard_groups_37661

133.61 +- 63.96

0.09 +- 0.20

precursor_jaccard_groups_3570

414.92 +- 442.96

0.06 +- 0.12

precursor_jaccard_groups_208

41.61 +- 0.00

0.10 +- 0.09

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (2/2) Major Facilitator Superfamily
PF00440 (2/2) Bacterial regulatory proteins, tetR family
PF00067 (2/2) Cytochrome P450

precursor_jaccard_groups_21036

453.70 +- 99.16

0.03 +- 0.02

precursor_jaccard_groups_6573

164.69 +- 103.36

0.05 +- 0.04

precursor_jaccard_groups_1587

52.74 +- 14.93

0.06 +- 0.05

PF05331 (6/6) Protein of unknown function (DUF742)
PF04149 (6/6) Domain of unknown function (DUF397)
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF00067 (6/6) Cytochrome P450

precursor_jaccard_groups_44422

1548.00 +- 0.00

0.01 +- 0.00

precursor_jaccard_groups_41940

347.93 +- 153.74

0.05 +- 0.08

precursor_jaccard_groups_37196

194.00 +- 64.00

0.01 +- 0.01

PF05901 (2/2) Excalibur calcium-binding domain
PF01738 (2/2) Dienelactone hydrolase family
PF00293 (2/2) NUDIX domain

precursor_jaccard_groups_102

500.84 +- 250.71

0.02 +- 0.05

precursor_jaccard_groups_37762

53.39 +- 20.89

0.05 +- 0.04

precursor_jaccard_groups_1299

56.37 +- 16.27

0.08 +- 0.07

precursor_jaccard_groups_22033

760.47 +- 374.44

0.04 +- 0.12

precursor_jaccard_groups_27906

149.12 +- 39.59

0.06 +- 0.02

precursor_jaccard_groups_44055

1163.94 +- 693.66

0.02 +- 0.01

precursor_jaccard_groups_43169

107.29 +- 28.50

0.04 +- 0.04

precursor_jaccard_groups_1997

38.95 +- 9.95

0.06 +- 0.09

PF17866 (7/7) AAA lid domain
PF13229 (7/7) Right handed beta helix region
PF00652 (7/7) Ricin-type beta-trefoil lectin domain
PF00082 (7/7) Subtilase family
PF00004 (7/7) ATPase family associated with various cellular activities (AAA)

precursor_jaccard_groups_4897

221.77 +- 79.53

0.05 +- 0.04

precursor_jaccard_groups_17197

1855.31 +- 282.62

0.04 +- 0.15

precursor_jaccard_groups_25486

1040.00 +- 0.00

0.01 +- 0.00

precursor_jaccard_groups_41790

133.48 +- 31.64

0.04 +- 0.04

precursor_jaccard_groups_8066

858.49 +- 193.39

0.01 +- 0.00

precursor_jaccard_groups_8416

174.02 +- 47.17

0.07 +- 0.10

precursor_jaccard_groups_21453

186.14 +- 8.86

0.03 +- 0.04

precursor_jaccard_groups_43205

100.28 +- 9.84

0.06 +- 0.06

precursor_jaccard_groups_3309

637.59 +- 4.54

0.03 +- 0.02

precursor_jaccard_groups_43369

100.71 +- 10.71

0.06 +- 0.04

PF04672 (2/2) S-adenosyl methyltransferase
PF01872 (2/2) RibD C-terminal domain
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_jaccard_groups_11383

336.40 +- 91.11

0.01 +- 0.01

PF13649 (4/4) Methyltransferase domain
PF07730 (4/4) Histidine kinase
PF00196 (4/4) Bacterial regulatory proteins, luxR family
PF00072 (4/4) Response regulator receiver domain

precursor_jaccard_groups_26078

627.35 +- 64.02

0.01 +- 0.01

PF13191 (2/2) AAA ATPase domain
PF13185 (2/2) GAF domain
PF04055 (2/2) Radical SAM superfamily
PF03704 (2/2) Bacterial transcriptional activator domain
PF00486 (2/2) Transcriptional regulatory protein, C terminal
PF00211 (2/2) Adenylate and Guanylate cyclase catalytic domain
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector

precursor_jaccard_groups_9943

166.79 +- 16.68

0.05 +- 0.06

precursor_jaccard_groups_29968

274.58 +- 189.71

0.03 +- 0.05

precursor_jaccard_groups_5577

183.10 +- 82.91

0.01 +- 0.01

PF04655 (6/6) Aminoglycoside/hydroxyurea antibiotic resistance kinase

precursor_jaccard_groups_10911

592.86 +- 404.30

0.05 +- 0.08

precursor_jaccard_groups_35210

100.79 +- 5.13

0.06 +- 0.07

precursor_jaccard_groups_18487

358.75 +- 32.16

0.01 +- 0.01

precursor_jaccard_groups_43014

1363.59 +- 571.41

0.01 +- 0.01

precursor_jaccard_groups_7559

320.07 +- 19.07

0.05 +- 0.02

precursor_jaccard_groups_30

272.98 +- 0.99

0.09 +- 0.18

precursor_jaccard_groups_36

326.29 +- 70.74

0.07 +- 0.20

PF13400 (5/5) Putative Flp pilus-assembly TadE/G-like
PF00691 (5/5) OmpA family
PF00482 (5/5) Type II secretion system (T2SS), protein F
TIGR03177 (4/5) Flp pilus assembly protein CpaB
PF16976 (4/5) Flp pilus assembly protein RcpC/CpaB
PF13614 (4/5) AAA domain
PF07811 (4/5) TadE-like protein
PF07730 (4/5) Histidine kinase
PF00437 (4/5) Type II/IV secretion system protein
PF00196 (4/5) Bacterial regulatory proteins, luxR family
PF00072 (4/5) Response regulator receiver domain
PF15648 (3/5) Restriction endonuclease fold toxin 5
PF13231 (3/5) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF00528 (3/5) Binding-protein-dependent transport system inner membrane component
PF00496 (3/5) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00005 (3/5) ABC transporter

precursor_jaccard_groups_531

366.81 +- 92.54

0.07 +- 0.08

precursor_jaccard_groups_26233

117.00 +- 13.00

0.02 +- 0.01

PF08386 (2/2) TAP-like protein
PF08031 (2/2) Berberine and berberine like
PF01565 (2/2) FAD binding domain
PF00561 (2/2) alpha/beta hydrolase fold

precursor_jaccard_groups_5776

795.64 +- 536.08

0.03 +- 0.08

precursor_jaccard_groups_24455

155.40 +- 85.40

0.04 +- 0.04

precursor_jaccard_groups_11745

51.32 +- 24.99

0.05 +- 0.06

precursor_jaccard_groups_7987

383.81 +- 168.05

0.01 +- 0.03

precursor_jaccard_groups_24517

1607.67 +- 212.33

0.01 +- 0.00

precursor_jaccard_groups_10967

68.37 +- 29.84

0.07 +- 0.06

precursor_jaccard_groups_1313

427.40 +- 123.00

0.03 +- 0.03

precursor_jaccard_groups_4352

479.19 +- 156.31

0.02 +- 0.01

precursor_jaccard_groups_17640

977.21 +- 452.79

0.01 +- 0.02

precursor_jaccard_groups_26806

227.25 +- 162.75

0.03 +- 0.05

precursor_jaccard_groups_30307

237.03 +- 98.37

0.02 +- 0.04

precursor_jaccard_groups_6905

276.85 +- 62.50

0.02 +- 0.02

PF13924 (3/3) Lipocalin-like domain
PF07690 (3/3) Major Facilitator Superfamily
PF00857 (3/3) Isochorismatase family
PF00171 (3/3) Aldehyde dehydrogenase family
PF00082 (2/3) Subtilase family

precursor_jaccard_groups_20179

47.53 +- 2.00

0.06 +- 0.06

PF01243 (2/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I

precursor_jaccard_groups_4527

119.08 +- 0.00

0.03 +- 0.01

precursor_jaccard_groups_14333

125.56 +- 76.73

0.02 +- 0.01

precursor_jaccard_groups_710

1621.00 +- 1136.16

0.02 +- 0.06

PF17914 (31/31) HopA1 effector protein family
PF00664 (31/31) ABC transporter transmembrane region
PF00296 (31/31) Luciferase-like monooxygenase
PF00005 (31/31) ABC transporter
PF02441 (30/31) Flavoprotein
PF00675 (30/31) Insulinase (Peptidase family M16)
PF05193 (26/31) Peptidase M16 inactive domain
PF00891 (26/31) O-methyltransferase domain
PF01636 (25/31) Phosphotransferase enzyme family

precursor_jaccard_groups_1823

675.94 +- 720.50

0.03 +- 0.12

TIGR01850 (12/12) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (12/12) alpha-L-glutamate ligase, RimK family
PF13193 (12/12) AMP-binding enzyme C-terminal domain
PF08443 (12/12) RimK-like ATP-grasp domain
PF02780 (12/12) Transketolase, C-terminal domain
PF02779 (12/12) Transketolase, pyrimidine binding domain
PF02771 (12/12) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (12/12) Acyl-CoA dehydrogenase, middle domain
PF01118 (12/12) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (12/12) AMP-binding enzyme
PF00456 (12/12) Transketolase, thiamine diphosphate binding domain
PF00441 (12/12) Acyl-CoA dehydrogenase, C-terminal domain
PF03466 (9/12) LysR substrate binding domain
PF00126 (9/12) Bacterial regulatory helix-turn-helix protein, lysR family

precursor_jaccard_groups_8841

303.45 +- 53.54

0.02 +- 0.01

precursor_jaccard_groups_43944

69.46 +- 4.96

0.04 +- 0.04

precursor_jaccard_groups_2843

4220.18 +- 876.74

0.01 +- 0.01

TIGR03882 (7/7) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (7/7) SagB-type dehydrogenase domain
TIGR03604 (7/7) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (7/7) Lantibiotic biosynthesis dehydratase C-term
PF02624 (7/7) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/7) Nitroreductase family
PF00440 (6/7) Bacterial regulatory proteins, tetR family
PF00067 (6/7) Cytochrome P450
TIGR01891 (5/7) amidohydrolase
PF01546 (5/7) Peptidase family M20/M25/M40
PF00005 (5/7) ABC transporter
PF04738 (4/7) Lantibiotic dehydratase, N terminus
PF01061 (4/7) ABC-2 type transporter

precursor_jaccard_groups_14422

43.41 +- 0.41

0.07 +- 0.09

precursor_jaccard_groups_4553

235.19 +- 41.40

0.02 +- 0.01

precursor_jaccard_groups_660

133.51 +- 85.83

0.03 +- 0.02

PF01471 (9/9) Putative peptidoglycan binding domain
PF00561 (9/9) alpha/beta hydrolase fold
PF08386 (8/9) TAP-like protein
PF13515 (6/9) Fusaric acid resistance protein-like

precursor_jaccard_groups_6440

216.00 +- 44.00

0.03 +- 0.04

TIGR01910 (2/2) peptidase, ArgE/DapE family
PF01546 (2/2) Peptidase family M20/M25/M40
PF01510 (2/2) N-acetylmuramoyl-L-alanine amidase
PF00107 (1/2) Zinc-binding dehydrogenase

precursor_jaccard_groups_651

2220.43 +- 119.57

0.01 +- 0.00

precursor_jaccard_groups_4416

125.11 +- 36.14

0.05 +- 0.06

precursor_jaccard_groups_9210

622.29 +- 125.90

0.01 +- 0.02

precursor_jaccard_groups_9269

43.48 +- 8.68

0.07 +- 0.05

precursor_jaccard_groups_28703

1580.73 +- 635.73

0.02 +- 0.04

precursor_jaccard_groups_13407

1191.19 +- 1181.25

0.05 +- 0.18

precursor_jaccard_groups_826

120.00 +- 0.00

0.10 +- 0.25

precursor_jaccard_groups_981

222.67 +- 78.34

0.03 +- 0.02

precursor_jaccard_groups_1387

174.09 +- 18.88

0.07 +- 0.09

precursor_jaccard_groups_31238

142.22 +- 29.78

0.06 +- 0.03

precursor_jaccard_groups_16546

24.19 +- 0.00

0.08 +- 0.03

PF08240 (2/2) Alcohol dehydrogenase GroES-like domain
PF01361 (2/2) Tautomerase enzyme

precursor_jaccard_groups_6978

47.10 +- 5.79

0.06 +- 0.05

precursor_jaccard_groups_43400

971.25 +- 3.75

0.01 +- 0.00

precursor_jaccard_groups_35828

694.47 +- 44.47

0.01 +- 0.00

precursor_jaccard_groups_34206

306.43 +- 83.57

0.01 +- 0.00

precursor_jaccard_groups_28096

777.00 +- 3.00

0.01 +- 0.00

precursor_jaccard_groups_11184

144.69 +- 113.31

0.04 +- 0.06

precursor_jaccard_groups_1003

472.48 +- 223.76

0.05 +- 0.13

TIGR01733 (3/3) amino acid adenylation domain
PF13560 (3/3) Helix-turn-helix domain
PF13193 (3/3) AMP-binding enzyme C-terminal domain
PF07690 (3/3) Major Facilitator Superfamily
PF06368 (3/3) Methylaspartate mutase E chain (MutE)
PF03621 (3/3) MbtH-like protein
PF02668 (3/3) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (3/3) B12 binding domain
PF01645 (3/3) Conserved region in glutamate synthase
PF00975 (3/3) Thioesterase domain
PF00668 (3/3) Condensation domain
PF00550 (3/3) Phosphopantetheine attachment site
PF00501 (3/3) AMP-binding enzyme
PF00152 (3/3) tRNA synthetases class II (D, K and N)
PF01648 (2/3) 4'-phosphopantetheinyl transferase superfamily

precursor_jaccard_groups_20536

97.43 +- 4.08

0.02 +- 0.02

PF01636 (3/3) Phosphotransferase enzyme family
PF00300 (3/3) Histidine phosphatase superfamily (branch 1)

precursor_jaccard_groups_7977

371.41 +- 284.77

0.03 +- 0.08

precursor_jaccard_groups_12000

233.66 +- 123.26

0.02 +- 0.03

precursor_jaccard_groups_3188

358.32 +- 74.43

0.06 +- 0.03

precursor_jaccard_groups_32135

372.32 +- 128.18

0.03 +- 0.03

precursor_jaccard_groups_34449

571.90 +- 331.10

0.02 +- 0.03

precursor_jaccard_groups_1645

333.77 +- 152.43

0.02 +- 0.03

PF07291 (6/6) Methylamine utilisation protein MauE
PF00717 (6/6) Peptidase S24-like
PF00578 (6/6) AhpC/TSA family
PF00005 (6/6) ABC transporter
PF12833 (4/6) Helix-turn-helix domain
PF10502 (3/6) Signal peptidase, peptidase S26

precursor_jaccard_groups_8196

273.59 +- 115.10

0.03 +- 0.01

precursor_jaccard_groups_3616

196.34 +- 50.80

0.08 +- 0.07

precursor_jaccard_groups_14902

253.73 +- 93.57

0.05 +- 0.06

precursor_jaccard_groups_19995

212.38 +- 67.73

0.04 +- 0.06

precursor_jaccard_groups_19998

24.99 +- 2.38

0.08 +- 0.07

PF00652 (2/2) Ricin-type beta-trefoil lectin domain
PF00457 (2/2) Glycosyl hydrolases family 11
PF00331 (2/2) Glycosyl hydrolase family 10

precursor_jaccard_groups_30270

1430.00 +- 130.00

0.01 +- 0.00

precursor_jaccard_groups_14043

332.84 +- 267.53

0.06 +- 0.12

precursor_jaccard_groups_26753

21.30 +- 0.66

0.09 +- 0.13

precursor_jaccard_groups_34537

168.50 +- 39.50

0.03 +- 0.02

PF13377 (2/2) Periplasmic binding protein-like domain
PF13185 (2/2) GAF domain
PF08448 (2/2) PAS fold
PF07228 (2/2) Stage II sporulation protein E (SpoIIE)
PF01408 (2/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (2/2) Xylose isomerase-like TIM barrel
PF00356 (2/2) Bacterial regulatory proteins, lacI family

precursor_jaccard_groups_33923

103.09 +- 21.09

0.06 +- 0.08

precursor_jaccard_groups_26615

122.27 +- 27.73

0.02 +- 0.01

precursor_jaccard_groups_42614

134.38 +- 26.88

0.02 +- 0.01

precursor_jaccard_groups_42116

156.96 +- 65.90

0.02 +- 0.03

precursor_jaccard_groups_37472

80.77 +- 3.37

0.06 +- 0.08

precursor_jaccard_groups_42252

64.13 +- 5.87

0.06 +- 0.13

precursor_jaccard_groups_16345

224.43 +- 53.86

0.03 +- 0.04

precursor_jaccard_groups_26100

189.23 +- 42.98

0.02 +- 0.01

precursor_jaccard_groups_9042

4562.99 +- 1627.42

0.01 +- 0.03

PF17914 (5/5) HopA1 effector protein family
PF13649 (5/5) Methyltransferase domain
PF05193 (5/5) Peptidase M16 inactive domain
PF02441 (5/5) Flavoprotein
PF00675 (5/5) Insulinase (Peptidase family M16)
PF00664 (5/5) ABC transporter transmembrane region
PF00296 (5/5) Luciferase-like monooxygenase
PF00005 (5/5) ABC transporter
PF01527 (4/5) Transposase
PF01061 (4/5) ABC-2 type transporter

precursor_jaccard_groups_42508

61.28 +- 3.22

0.05 +- 0.03

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF02386 (2/2) Cation transport protein
PF02254 (2/2) TrkA-N domain
PF02080 (2/2) TrkA-C domain
PF00501 (2/2) AMP-binding enzyme

precursor_jaccard_groups_25436

195.00 +- 0.00

0.02 +- 0.00

precursor_jaccard_groups_2566

131.54 +- 3.07

0.09 +- 0.06

precursor_jaccard_groups_22912

205.89 +- 16.36

0.06 +- 0.11

precursor_jaccard_groups_29429

30.46 +- 5.65

0.07 +- 0.12

precursor_jaccard_groups_11638

1255.97 +- 999.97

0.03 +- 0.06

precursor_jaccard_groups_29587

38.91 +- 7.53

0.08 +- 0.05

PF13796 (2/2) Putative sensor
PF07730 (2/2) Histidine kinase
PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_jaccard_groups_30588

1029.17 +- 97.50

0.01 +- 0.01

precursor_jaccard_groups_11636

167.66 +- 10.77

0.06 +- 0.03

precursor_jaccard_groups_215

32.76 +- 4.10

0.06 +- 0.03

PF08007 (2/2) Cupin superfamily protein
PF00248 (2/2) Aldo/keto reductase family

precursor_jaccard_groups_3468

75.88 +- 0.00

0.07 +- 0.07

precursor_jaccard_groups_742

82.30 +- 46.49

0.05 +- 0.02

PF13471 (40/40) Transglutaminase-like superfamily
PF05402 (40/40) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (40/40) Asparagine synthase

precursor_jaccard_groups_41550

702.33 +- 200.67

0.01 +- 0.00

precursor_jaccard_groups_32091

895.44 +- 308.77

0.02 +- 0.03

precursor_jaccard_groups_14462

144.98 +- 11.02

0.09 +- 0.06

precursor_jaccard_groups_1598

57.96 +- 12.04

0.05 +- 0.10

precursor_jaccard_groups_41497

154.25 +- 11.20

0.05 +- 0.16

precursor_jaccard_groups_15368

396.47 +- 171.88

0.01 +- 0.02

precursor_jaccard_groups_9130

261.23 +- 64.11

0.01 +- 0.01

precursor_jaccard_groups_29102

175.06 +- 37.41

0.03 +- 0.04

precursor_jaccard_groups_13679

34.39 +- 12.89

0.09 +- 0.08

PF02031 (2/2) Streptomyces extracellular neutral proteinase (M7) family
PF01810 (2/2) LysE type translocator

precursor_jaccard_groups_28294

246.49 +- 143.51

0.04 +- 0.15

precursor_jaccard_groups_15412

138.46 +- 43.67

0.03 +- 0.02

precursor_jaccard_groups_3796

885.57 +- 176.07

0.01 +- 0.01

precursor_jaccard_groups_2704

196.89 +- 6.51

0.04 +- 0.15

precursor_jaccard_groups_8499

174.93 +- 114.89

0.03 +- 0.05

precursor_jaccard_groups_43471

151.58 +- 28.42

0.02 +- 0.02

PF13302 (2/2) Acetyltransferase (GNAT) domain
PF07690 (2/2) Major Facilitator Superfamily
PF01053 (2/2) Cys/Met metabolism PLP-dependent enzyme

precursor_jaccard_groups_27320

481.90 +- 168.10

0.02 +- 0.02

precursor_jaccard_groups_18062

291.05 +- 29.25

0.08 +- 0.18

precursor_jaccard_groups_1609

46.64 +- 3.06

0.06 +- 0.07

PF07730 (3/3) Histidine kinase
PF00196 (3/3) Bacterial regulatory proteins, luxR family
PF00072 (3/3) Response regulator receiver domain
PF13649 (2/3) Methyltransferase domain

precursor_jaccard_groups_870

104.64 +- 38.90

0.06 +- 0.07

precursor_jaccard_groups_11307

152.71 +- 40.50

0.02 +- 0.01

PF07690 (3/3) Major Facilitator Superfamily
PF01227 (3/3) GTP cyclohydrolase I
PF00293 (3/3) NUDIX domain

precursor_jaccard_groups_4943

375.44 +- 131.77

0.09 +- 0.21

precursor_jaccard_groups_23563

3120.00 +- 0.00

0.01 +- 0.00

precursor_jaccard_groups_7393

47.52 +- 9.22

0.04 +- 0.05

PF09586 (3/3) Bacterial membrane protein YfhO
PF04138 (3/3) GtrA-like protein
PF00535 (3/3) Glycosyl transferase family 2

precursor_jaccard_groups_1131

516.00 +- 129.00

0.01 +- 0.00

precursor_jaccard_groups_26322

7843.20 +- 6508.80

0.05 +- 0.15

precursor_jaccard_groups_37336

23.45 +- 0.00

0.09 +- 0.07

PF13370 (2/2) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (2/2) Methyltransferase domain
PF00753 (2/2) Metallo-beta-lactamase superfamily

precursor_jaccard_groups_41413

650.00 +- 0.00

0.02 +- 0.00

precursor_jaccard_groups_19421

322.50 +- 0.00

0.02 +- 0.00

precursor_jaccard_groups_1730

27.06 +- 5.19

0.09 +- 0.10

precursor_jaccard_groups_883

91.17 +- 58.33

0.03 +- 0.02

PF12833 (18/18) Helix-turn-helix domain
PF02311 (18/18) AraC-like ligand binding domain
PF00150 (18/18) Cellulase (glycosyl hydrolase family 5)

precursor_jaccard_groups_33885

132.91 +- 39.09

0.05 +- 0.09

precursor_jaccard_groups_39349

157.71 +- 71.71

0.04 +- 0.08

precursor_jaccard_groups_3728

554.81 +- 177.49

0.02 +- 0.02

precursor_jaccard_groups_2220

57.64 +- 2.36

0.07 +- 0.09

precursor_jaccard_groups_21166

1225.09 +- 465.17

0.01 +- 0.01

PF13471 (3/3) Transglutaminase-like superfamily
PF05402 (3/3) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (3/3) Asparagine synthase
PF00664 (3/3) ABC transporter transmembrane region
PF00296 (3/3) Luciferase-like monooxygenase
PF00005 (3/3) ABC transporter
TIGR04353 (2/3) PqqD family protein, HPr-rel-A system
PF13646 (2/3) HEAT repeats
PF13411 (2/3) MerR HTH family regulatory protein

precursor_jaccard_groups_23668

230.67 +- 116.00

0.02 +- 0.03

precursor_jaccard_groups_253

355.50 +- 160.50

0.03 +- 0.03

precursor_jaccard_groups_91

243.84 +- 133.73

0.07 +- 0.08

precursor_jaccard_groups_9372

400.13 +- 221.16

0.05 +- 0.17

precursor_jaccard_groups_26664

1942.50 +- 7.50

0.01 +- 0.00

precursor_jaccard_groups_21200

398.33 +- 178.68

0.02 +- 0.01

precursor_jaccard_groups_32436

476.67 +- 43.33

0.01 +- 0.00

PF18029 (2/2) Glyoxalase-like domain
PF07690 (2/2) Major Facilitator Superfamily
PF00903 (2/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_jaccard_groups_2686

203.13 +- 221.37

0.05 +- 0.10

precursor_jaccard_groups_29077

183.91 +- 13.29

0.08 +- 0.06

precursor_jaccard_groups_24503

73.19 +- 11.76

0.08 +- 0.08

precursor_jaccard_groups_17655

877.59 +- 552.41

0.02 +- 0.06

precursor_jaccard_groups_4347

935.22 +- 296.60

0.01 +- 0.00

precursor_jaccard_groups_3429

1363.95 +- 1630.95

0.04 +- 0.08

precursor_jaccard_groups_18235

765.63 +- 127.45

0.01 +- 0.01

precursor_jaccard_groups_21063

650.00 +- 0.00

0.01 +- 0.00

PF13367 (2/2) PrsW family intramembrane metalloprotease

precursor_jaccard_groups_792

680.47 +- 421.39

0.05 +- 0.09

TIGR04364 (6/6) methyltransferase, FxLD system
TIGR04363 (6/6) FxLD family lantipeptide
TIGR03891 (6/6) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF05331 (6/6) Protein of unknown function (DUF742)
PF05147 (6/6) Lanthionine synthetase C-like protein
PF04738 (6/6) Lantibiotic dehydratase, N terminus
PF03259 (6/6) Roadblock/LC7 domain
PF03029 (6/6) Conserved hypothetical ATP binding protein
PF01427 (6/6) D-ala-D-ala dipeptidase
PF01135 (6/6) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00293 (6/6) NUDIX domain
PF00196 (6/6) Bacterial regulatory proteins, luxR family
PF00005 (6/6) ABC transporter
PF02771 (5/6) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (5/6) Acyl-CoA dehydrogenase, middle domain
PF01590 (5/6) GAF domain
PF00441 (5/6) Acyl-CoA dehydrogenase, C-terminal domain
PF02518 (4/6) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00723 (4/6) Glycosyl hydrolases family 15
PF13671 (3/6) AAA domain
PF13649 (3/6) Methyltransferase domain

precursor_jaccard_groups_18533

358.87 +- 76.47

0.03 +- 0.03

precursor_jaccard_groups_6734

122.11 +- 15.00

0.08 +- 0.21

precursor_jaccard_groups_20649

91.36 +- 15.97

0.06 +- 0.11

precursor_jaccard_groups_7647

2698.22 +- 1333.42

0.01 +- 0.01

TIGR03882 (6/6) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (6/6) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (6/6) Lantibiotic biosynthesis dehydratase C-term
PF13560 (6/6) Helix-turn-helix domain
PF04149 (6/6) Domain of unknown function (DUF397)
PF02624 (6/6) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (6/6) Nitroreductase family
PF00196 (5/6) Bacterial regulatory proteins, luxR family
TIGR03891 (3/6) thiopeptide-type bacteriocin biosynthesis domain

precursor_jaccard_groups_5516

128.12 +- 45.26

0.08 +- 0.18

precursor_jaccard_groups_28413

69.81 +- 25.74

0.07 +- 0.06

precursor_jaccard_groups_24164

48.84 +- 15.40

0.09 +- 0.08

precursor_jaccard_groups_670

203.30 +- 256.64

0.04 +- 0.05

TIGR03296 (4/4) M6 family metalloprotease domain
PF01070 (2/4) FMN-dependent dehydrogenase

precursor_jaccard_groups_8262

282.51 +- 110.62

0.01 +- 0.01

precursor_jaccard_groups_172

318.82 +- 276.51

0.05 +- 0.08

TIGR01525 (5/5) heavy metal translocating P-type ATPase
PF04314 (5/5) Copper chaperone PCu(A)C
PF00702 (5/5) haloacid dehalogenase-like hydrolase
PF00403 (5/5) Heavy-metal-associated domain
PF00122 (5/5) E1-E2 ATPase
TIGR02937 (4/5) RNA polymerase sigma factor, sigma-70 family
TIGR00802 (4/5) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (4/5) GYF domain 2
PF13421 (4/5) SPFH domain-Band 7 family
PF08281 (4/5) Sigma-70, region 4
PF07690 (4/5) Major Facilitator Superfamily
PF04542 (4/5) Sigma-70 region 2
PF03824 (4/5) High-affinity nickel-transport protein
PF13738 (3/5) Pyridine nucleotide-disulphide oxidoreductase
PF01070 (3/5) FMN-dependent dehydrogenase
PF00067 (3/5) Cytochrome P450

precursor_jaccard_groups_27768

960.72 +- 458.28

0.02 +- 0.02

precursor_jaccard_groups_10899

491.70 +- 429.24

0.02 +- 0.05

precursor_jaccard_groups_836

687.94 +- 313.54

0.02 +- 0.02

TIGR03891 (3/3) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (3/3) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (3/3) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (3/3) Lantibiotic biosynthesis dehydratase C-term
PF05147 (3/3) Lanthionine synthetase C-like protein
PF04738 (3/3) Lantibiotic dehydratase, N terminus
PF02624 (3/3) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (3/3) Nitroreductase family
PF00069 (3/3) Protein kinase domain
TIGR03605 (2/3) SagB-type dehydrogenase domain
PF00494 (2/3) Squalene/phytoene synthase

precursor_jaccard_groups_380

182.02 +- 102.07

0.04 +- 0.05

TIGR03975 (14/14) ribosomal peptide maturation radical SAM protein 1
PF07690 (14/14) Major Facilitator Superfamily
PF02310 (14/14) B12 binding domain
PF00326 (14/14) Prolyl oligopeptidase family
PF04055 (13/14) Radical SAM superfamily

precursor_jaccard_groups_6961

660.47 +- 112.74

0.01 +- 0.01

precursor_jaccard_groups_33409

388.00 +- 128.00

0.01 +- 0.00

precursor_jaccard_groups_27103

143.00 +- 117.00

0.04 +- 0.07

PF09848 (2/2) Uncharacterized conserved protein (DUF2075)
PF07728 (2/2) AAA domain (dynein-related subfamily)
PF00931 (2/2) NB-ARC domain

precursor_jaccard_groups_43595

101.28 +- 23.28

0.05 +- 0.10

precursor_jaccard_groups_12176

186.44 +- 101.19

0.02 +- 0.02

precursor_jaccard_groups_40521

50.96 +- 10.96

0.06 +- 0.07

PF11303 (2/2) Protein of unknown function (DUF3105)
PF09335 (2/2) SNARE associated Golgi protein
PF02388 (2/2) FemAB family
PF00507 (2/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

precursor_jaccard_groups_19576

215.00 +- 60.81

0.01 +- 0.01

PF03033 (3/3) Glycosyltransferase family 28 N-terminal domain
PF00756 (3/3) Putative esterase
PF00201 (3/3) UDP-glucoronosyl and UDP-glucosyl transferase

precursor_jaccard_groups_44613

91.60 +- 0.33

0.10 +- 0.29

precursor_jaccard_groups_44970

250.40 +- 9.60

0.02 +- 0.02

PF13365 (2/2) Trypsin-like peptidase domain
PF00400 (2/2) WD domain, G-beta repeat
PF00248 (2/2) Aldo/keto reductase family
PF07721 (1/2) Tetratricopeptide repeat

precursor_jaccard_groups_3196

79.05 +- 17.93

0.08 +- 0.03

precursor_jaccard_groups_39304

376.25 +- 0.00

0.03 +- 0.03

precursor_jaccard_groups_11860

114.31 +- 18.14

0.08 +- 0.04

precursor_jaccard_groups_44856

766.32 +- 13.68

0.01 +- 0.00

precursor_jaccard_groups_38287

154.80 +- 0.00

0.02 +- 0.01

precursor_jaccard_groups_8003

2401.56 +- 1135.16

0.02 +- 0.01

precursor_jaccard_groups_34641

462.83 +- 311.17

0.02 +- 0.04

precursor_jaccard_groups_42264

130.00 +- 70.00

0.04 +- 0.03

precursor_jaccard_groups_14078

150.50 +- 136.83

0.03 +- 0.02

PF00768 (4/4) D-alanyl-D-alanine carboxypeptidase
PF00067 (4/4) Cytochrome P450
PF03745 (2/4) Domain of unknown function (DUF309)

precursor_jaccard_groups_37594

109.51 +- 1.92

0.04 +- 0.03

precursor_jaccard_groups_5839

1561.23 +- 946.56

0.02 +- 0.07

PF13622 (6/6) Thioesterase-like superfamily
PF07690 (6/6) Major Facilitator Superfamily
PF00550 (6/6) Phosphopantetheine attachment site
PF00501 (6/6) AMP-binding enzyme
PF00487 (6/6) Fatty acid desaturase
PF00301 (6/6) Rubredoxin
PF00067 (6/6) Cytochrome P450
PF12679 (4/6) ABC-2 family transporter protein
PF12146 (4/6) Serine aminopeptidase, S33
PF00005 (4/6) ABC transporter
TIGR00711 (3/6) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF00392 (3/6) Bacterial regulatory proteins, gntR family

precursor_jaccard_groups_2272

359.93 +- 257.30

0.04 +- 0.07

precursor_jaccard_groups_5207

964.27 +- 325.73

0.01 +- 0.02

precursor_jaccard_groups_40

353.21 +- 291.79

0.03 +- 0.08

TIGR01733 (2/2) amino acid adenylation domain
TIGR01720 (2/2) non-ribosomal peptide synthase domain TIGR01720
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF03621 (2/2) MbtH-like protein
PF00975 (2/2) Thioesterase domain
PF00668 (2/2) Condensation domain
PF00550 (2/2) Phosphopantetheine attachment site
PF00501 (2/2) AMP-binding enzyme
PF00155 (2/2) Aminotransferase class I and II
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
PF12680 (1/2) SnoaL-like domain
PF08242 (1/2) Methyltransferase domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01070 (1/2) FMN-dependent dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

precursor_jaccard_groups_2073

802.19 +- 237.81

0.01 +- 0.00

TIGR03882 (5/5) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (5/5) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (5/5) Lantibiotic biosynthesis dehydratase C-term
PF04738 (5/5) Lantibiotic dehydratase, N terminus
PF02624 (5/5) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (5/5) Nitroreductase family
TIGR03605 (3/5) SagB-type dehydrogenase domain
PF13191 (3/5) AAA ATPase domain
PF00196 (3/5) Bacterial regulatory proteins, luxR family

precursor_jaccard_groups_4767

234.57 +- 34.56

0.01 +- 0.00

precursor_jaccard_groups_35789

1105.00 +- 0.00

0.02 +- 0.00

precursor_jaccard_groups_16211

260.13 +- 5.78

0.02 +- 0.01

precursor_jaccard_groups_584

192.97 +- 127.67

0.05 +- 0.03

precursor_jaccard_groups_10702

49.71 +- 15.29

0.07 +- 0.08

precursor_jaccard_groups_946

505.07 +- 225.49

0.03 +- 0.05

PF05147 (23/23) Lanthionine synthetase C-like protein
PF04672 (23/23) S-adenosyl methyltransferase
PF00664 (23/23) ABC transporter transmembrane region
PF00326 (23/23) Prolyl oligopeptidase family
PF00069 (23/23) Protein kinase domain
PF00005 (23/23) ABC transporter

precursor_jaccard_groups_25249

85.00 +- 45.00

0.03 +- 0.03

PF01874 (2/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (2/2) Dioxygenase

precursor_jaccard_groups_42565

523.42 +- 54.35

0.05 +- 0.08

precursor_jaccard_groups_18179

50.96 +- 24.18

0.05 +- 0.03

PF13520 (3/3) Amino acid permease
PF00202 (3/3) Aminotransferase class-III
PF00171 (3/3) Aldehyde dehydrogenase family

precursor_jaccard_groups_18473

332.14 +- 118.84

0.02 +- 0.01

PF07690 (3/3) Major Facilitator Superfamily
PF00884 (3/3) Sulfatase
PF12697 (2/3) Alpha/beta hydrolase family

precursor_jaccard_groups_7175

218.17 +- 57.06

0.05 +- 0.06

precursor_jaccard_groups_18578

63.35 +- 11.31

0.05 +- 0.03

PF07992 (3/3) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (3/3) UTRA domain
PF01925 (3/3) Sulfite exporter TauE/SafE
PF00392 (3/3) Bacterial regulatory proteins, gntR family

precursor_jaccard_groups_29183

533.02 +- 31.35

0.01 +- 0.00

precursor_jaccard_groups_2398

953.88 +- 214.88

0.01 +- 0.01

precursor_jaccard_groups_32647

381.16 +- 102.59

0.02 +- 0.02

PF02225 (2/2) PA domain
PF01978 (2/2) Sugar-specific transcriptional regulator TrmB
PF00196 (2/2) Bacterial regulatory proteins, luxR family
PF00082 (2/2) Subtilase family

precursor_jaccard_groups_21054

324.25 +- 46.50

0.01 +- 0.00

precursor_jaccard_groups_1683

1303.55 +- 601.09

0.02 +- 0.01

TIGR03898 (16/16) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (16/16) type 2 lantibiotic biosynthesis protein LanM
PF13575 (16/16) Domain of unknown function (DUF4135)
PF05147 (16/16) Lanthionine synthetase C-like protein
PF03412 (16/16) Peptidase C39 family
PF00664 (16/16) ABC transporter transmembrane region
PF00005 (16/16) ABC transporter
PF12679 (14/16) ABC-2 family transporter protein

precursor_jaccard_groups_4506

299.00 +- 23.50

0.05 +- 0.09

precursor_jaccard_groups_2899

191.56 +- 72.66

0.07 +- 0.11

precursor_jaccard_groups_45300

516.00 +- 0.00

0.01 +- 0.00

precursor_jaccard_groups_28463

24.72 +- 1.08

0.08 +- 0.08

precursor_jaccard_groups_29296

322.38 +- 56.79

0.02 +- 0.02

precursor_jaccard_groups_10796

1463.93 +- 1117.75

0.02 +- 0.01

precursor_jaccard_groups_24990

139.98 +- 39.33

0.04 +- 0.04

precursor_jaccard_groups_41969

433.58 +- 275.92

0.04 +- 0.03

precursor_jaccard_groups_124

359.72 +- 141.51

0.02 +- 0.04

precursor_jaccard_groups_27389

961.71 +- 70.29

0.01 +- 0.00

precursor_jaccard_groups_22400

300.06 +- 213.54

0.04 +- 0.05

precursor_jaccard_groups_12706

1070.36 +- 277.93

0.02 +- 0.01

PF17914 (4/4) HopA1 effector protein family
PF13649 (4/4) Methyltransferase domain
PF12698 (4/4) ABC-2 family transporter protein
PF02441 (4/4) Flavoprotein
PF01636 (4/4) Phosphotransferase enzyme family
PF00664 (4/4) ABC transporter transmembrane region
PF00005 (4/4) ABC transporter
PF13732 (3/4) Domain of unknown function (DUF4162)
PF00196 (3/4) Bacterial regulatory proteins, luxR family

precursor_jaccard_groups_37144

234.00 +- 26.00

0.01 +- 0.01

precursor_jaccard_groups_37140

454.25 +- 29.50

0.02 +- 0.02

precursor_jaccard_groups_848

137.11 +- 11.03

0.03 +- 0.04

PF13471 (4/4) Transglutaminase-like superfamily
PF13302 (4/4) Acetyltransferase (GNAT) domain
PF00733 (4/4) Asparagine synthase

precursor_jaccard_groups_4970

759.98 +- 690.09

0.06 +- 0.20

precursor_jaccard_groups_34265

118.75 +- 11.25

0.08 +- 0.11

precursor_jaccard_groups_10247

388.80 +- 1.47

0.01 +- 0.00

PF07690 (5/5) Major Facilitator Superfamily
PF01425 (5/5) Amidase
PF01244 (5/5) Membrane dipeptidase (Peptidase family M19)

precursor_jaccard_groups_1631

34.67 +- 0.00

0.09 +- 0.12

precursor_jaccard_groups_3153

108.35 +- 37.40

0.09 +- 0.06

PF13411 (3/3) MerR HTH family regulatory protein
PF03476 (3/3) MOSC N-terminal beta barrel domain
PF03473 (3/3) MOSC domain
PF01551 (3/3) Peptidase family M23
PF00248 (3/3) Aldo/keto reductase family

Entry name	Average score	Number of operons	Number of operons with antismash overlap	Nr of operons with known RiPP domains	Average COG score	Nr of operons passed filter	Common domains
Halogenase	1426.13 +- 1991.63	7	7	4	0.05 +- 0.18	7	10 PF04820 (7/7) Tryptophan halogenase PF00664 (5/7) ABC transporter transmembrane region PF00005 (5/7) ABC transporter TIGR03897 (4/7) type 2 lantibiotic biosynthesis protein LanM PF14867 (4/7) Lantibiotic alpha PF13601 (4/7) Winged helix DNA-binding domain PF13575 (4/7) Domain of unknown function (DUF4135) PF05147 (4/7) Lanthionine synthetase C-like protein PF03412 (4/7) Peptidase C39 family PF00296 (4/7) Luciferase-like monooxygenase
Acyltransferases	414.85 +- 530.77	260	109	33	0.05 +- 0.09	260	No common domains found
Transferring Alkyl or Aryl Groups Other than Methyl Groups	697.53 +- 788.60	37	24	0	0.05 +- 0.14	37	1 PF00275 (19/37) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
Glycosyltransferases	546.19 +- 678.37	62	12	7	0.03 +- 0.09	62	No common domains found
Transferring Aldehyde or Ketonic Groups	564.73 +- 487.29	43	24	1	0.04 +- 0.14	43	10 PF00456 (39/43) Transketolase, thiamine diphosphate binding domain PF02779 (37/43) Transketolase, pyrimidine binding domain TIGR01850 (34/43) N-acetyl-gamma-glutamyl-phosphate reductase PF08443 (34/43) RimK-like ATP-grasp domain PF01118 (34/43) Semialdehyde dehydrogenase, NAD binding domain TIGR00768 (30/43) alpha-L-glutamate ligase, RimK family TIGR01902 (23/43) N-acetyl-ornithine/N-acetyl-lysine deacetylase PF01546 (23/43) Peptidase family M20/M25/M40 PF01041 (23/43) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (23/43) Amino acid kinase family
Transferring One-Carbon Groups	753.50 +- 851.88	162	66	46	0.03 +- 0.09	162	No common domains found
Transferring Phosphorus-Containing Groups	435.80 +- 1086.83	193	63	17	0.05 +- 0.13	193	No common domains found
Transferring Sulfur-Containing Groups	464.98 +- 305.80	18	10	2	0.05 +- 0.04	18	18 PF01144 (16/18) Coenzyme A transferase PF00005 (15/18) ABC transporter PF13193 (14/18) AMP-binding enzyme C-terminal domain PF00501 (14/18) AMP-binding enzyme PF00378 (14/18) Enoyl-CoA hydratase/isomerase PF13561 (13/18) Enoyl-(Acyl carrier protein) reductase PF08545 (13/18) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (13/18) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02801 (13/18) Beta-ketoacyl synthase, C-terminal domain PF00196 (13/18) Bacterial regulatory proteins, luxR family PF00109 (13/18) Beta-ketoacyl synthase, N-terminal domain PF00106 (13/18) short chain dehydrogenase TIGR00976 (12/18) hydrolase CocE/NonD family protein PF08530 (12/18) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF02129 (12/18) X-Pro dipeptidyl-peptidase (S15 family) PF04909 (11/18) Amidohydrolase PF12679 (10/18) ABC-2 family transporter protein PF12697 (9/18) Alpha/beta hydrolase family
Transferring Nitrogenous Groups	622.73 +- 650.75	97	43	20	0.04 +- 0.13	97	2 PF07690 (59/97) Major Facilitator Superfamily PF00202 (59/97) Aminotransferase class-III

Entry name

Average score

Number of operons

Number of MIBiG operons

Number of operons with antismash overlap

Nr of operons with known RiPP domains

Average COG score

Nr of operons passed filter

Common domains

Halogenase

1426.13 +- 1991.63

0.05 +- 0.18

PF04820 (7/7) Tryptophan halogenase
PF00664 (5/7) ABC transporter transmembrane region
PF00005 (5/7) ABC transporter
TIGR03897 (4/7) type 2 lantibiotic biosynthesis protein LanM
PF14867 (4/7) Lantibiotic alpha
PF13601 (4/7) Winged helix DNA-binding domain
PF13575 (4/7) Domain of unknown function (DUF4135)
PF05147 (4/7) Lanthionine synthetase C-like protein
PF03412 (4/7) Peptidase C39 family
PF00296 (4/7) Luciferase-like monooxygenase

Acyltransferases

414.85 +- 530.77

260

109

0.05 +- 0.09

260

No common domains found

Transferring Alkyl or Aryl Groups Other than Methyl Groups

697.53 +- 788.60

0.05 +- 0.14

PF00275 (19/37) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)

Glycosyltransferases

546.19 +- 678.37

0.03 +- 0.09

No common domains found

Transferring Aldehyde or Ketonic Groups

564.73 +- 487.29

0.04 +- 0.14

PF00456 (39/43) Transketolase, thiamine diphosphate binding domain
PF02779 (37/43) Transketolase, pyrimidine binding domain
TIGR01850 (34/43) N-acetyl-gamma-glutamyl-phosphate reductase
PF08443 (34/43) RimK-like ATP-grasp domain
PF01118 (34/43) Semialdehyde dehydrogenase, NAD binding domain
TIGR00768 (30/43) alpha-L-glutamate ligase, RimK family
TIGR01902 (23/43) N-acetyl-ornithine/N-acetyl-lysine deacetylase
PF01546 (23/43) Peptidase family M20/M25/M40
PF01041 (23/43) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (23/43) Amino acid kinase family

Transferring One-Carbon Groups

753.50 +- 851.88

162

0.03 +- 0.09

162

No common domains found

Transferring Phosphorus-Containing Groups

435.80 +- 1086.83

193

0.05 +- 0.13

193

No common domains found

Transferring Sulfur-Containing Groups

464.98 +- 305.80

0.05 +- 0.04

PF01144 (16/18) Coenzyme A transferase
PF00005 (15/18) ABC transporter
PF13193 (14/18) AMP-binding enzyme C-terminal domain
PF00501 (14/18) AMP-binding enzyme
PF00378 (14/18) Enoyl-CoA hydratase/isomerase
PF13561 (13/18) Enoyl-(Acyl carrier protein) reductase
PF08545 (13/18) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (13/18) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (13/18) Beta-ketoacyl synthase, C-terminal domain
PF00196 (13/18) Bacterial regulatory proteins, luxR family
PF00109 (13/18) Beta-ketoacyl synthase, N-terminal domain
PF00106 (13/18) short chain dehydrogenase
TIGR00976 (12/18) hydrolase CocE/NonD family protein
PF08530 (12/18) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF02129 (12/18) X-Pro dipeptidyl-peptidase (S15 family)
PF04909 (11/18) Amidohydrolase
PF12679 (10/18) ABC-2 family transporter protein
PF12697 (9/18) Alpha/beta hydrolase family

Transferring Nitrogenous Groups

622.73 +- 650.75

0.04 +- 0.13

PF07690 (59/97) Major Facilitator Superfamily
PF00202 (59/97) Aminotransferase class-III

Entry name	Average score	Number of operons	Number of operons with antismash overlap	Nr of operons with known RiPP domains	Average COG score	Nr of operons passed filter	Common domains
GCF_001705785.1	177.99 +- 112.62	5	0	0	0.05 +- 0.05	5	1 PF07690 (3/5) Major Facilitator Superfamily
GCF_000716515.1	44.23 +- 0.00	1	1	1	0.07 +- 0.00	1	3 PF13471 (1/1) Transglutaminase-like superfamily PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (1/1) Asparagine synthase
GCF_004125265.1	466.63 +- 589.37	3	0	0	0.03 +- 0.05	3	1 PF00067 (2/3) Cytochrome P450
GCF_000720455.1	217.83 +- 233.93	3	1	0	0.04 +- 0.03	3	No common domains found
GCF_000721625.1	116.85 +- 0.00	1	1	1	0.09 +- 0.21	1	10 TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/1) SagB-type dehydrogenase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF13575 (1/1) Domain of unknown function (DUF4135) PF03412 (1/1) Peptidase C39 family PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (1/1) Nitroreductase family PF00664 (1/1) ABC transporter transmembrane region PF00067 (1/1) Cytochrome P450 PF00005 (1/1) ABC transporter
GCF_004195745.1	107.50 +- 0.00	1	0	0	0.02 +- 0.02	1	4 PF13515 (1/1) Fusaric acid resistance protein-like PF08386 (1/1) TAP-like protein PF01471 (1/1) Putative peptidoglycan binding domain PF00561 (1/1) alpha/beta hydrolase fold
GCF_002551345.1	545.43 +- 410.74	3	1	1	0.02 +- 0.02	3	1 PF00005 (2/3) ABC transporter
GCF_000966955.1	335.43 +- 221.84	3	0	0	0.03 +- 0.03	3	4 PF13377 (2/3) Periplasmic binding protein-like domain PF02065 (2/3) Melibiase PF00528 (2/3) Binding-protein-dependent transport system inner membrane component PF00356 (2/3) Bacterial regulatory proteins, lacI family
GCF_002019855.1	577.06 +- 772.10	5	1	0	0.04 +- 0.08	5	No common domains found
GCF_001414545.1	1419.00 +- 0.00	1	1	0	0.01 +- 0.00	1	18 PF16197 (1/1) Ketoacyl-synthetase C-terminal extension PF14765 (1/1) Polyketide synthase dehydratase PF13191 (1/1) AAA ATPase domain PF08659 (1/1) KR domain PF04820 (1/1) Tryptophan halogenase PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03704 (1/1) Bacterial transcriptional activator domain PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain PF01613 (1/1) Flavin reductase like domain PF00999 (1/1) Sodium/hydrogen exchanger family PF00975 (1/1) Thioesterase domain PF00931 (1/1) NB-ARC domain PF00698 (1/1) Acyl transferase domain PF00550 (1/1) Phosphopantetheine attachment site PF00486 (1/1) Transcriptional regulatory protein, C terminal PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain PF00107 (1/1) Zinc-binding dehydrogenase
GCF_002551105.1	451.50 +- 0.00	1	1	1	0.02 +- 0.02	1	6 PF05147 (1/1) Lanthionine synthetase C-like protein PF04672 (1/1) S-adenosyl methyltransferase PF00664 (1/1) ABC transporter transmembrane region PF00326 (1/1) Prolyl oligopeptidase family PF00069 (1/1) Protein kinase domain PF00005 (1/1) ABC transporter
GCF_002154385.1	113.75 +- 0.00	1	0	0	0.03 +- 0.01	1	5 PF17914 (1/1) HopA1 effector protein family PF13649 (1/1) Methyltransferase domain PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF00675 (1/1) Insulinase (Peptidase family M16)
GCF_000163875.1	418.54 +- 378.23	2	1	0	0.02 +- 0.05	2	21 TIGR01509 (2/2) HAD hydrolase, family IA, variant 3 PF13419 (2/2) Haloacid dehalogenase-like hydrolase PF18181 (1/2) SMODS and SLOG-associating 2TM effector domain 1 PF16864 (1/2) Dimerisation domain PF14015 (1/2) Protein of unknown function (DUF4231) PF13692 (1/2) Glycosyl transferases group 1 PF13676 (1/2) TIR domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13292 (1/2) 1-deoxy-D-xylulose-5-phosphate synthase PF12464 (1/2) Maltose acetyltransferase PF11941 (1/2) Domain of unknown function (DUF3459) PF08386 (1/2) TAP-like protein PF07728 (1/2) AAA domain (dynein-related subfamily) PF05729 (1/2) NACHT domain PF04149 (1/2) Domain of unknown function (DUF397) PF02388 (1/2) FemAB family PF01636 (1/2) Phosphotransferase enzyme family PF00891 (1/2) O-methyltransferase domain PF00561 (1/2) alpha/beta hydrolase fold PF00202 (1/2) Aminotransferase class-III PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
GCF_000718855.1	91.45 +- 44.83	4	1	1	0.05 +- 0.05	4	No common domains found
GCF_000384175.1	231.24 +- 173.22	4	0	1	0.04 +- 0.05	4	No common domains found
GCF_004195855.1	21.50 +- 0.00	1	0	0	0.09 +- 0.05	1	4 PF17074 (1/1) Darcynin, domain of unknown function PF08021 (1/1) Siderophore-interacting FAD-binding domain PF04954 (1/1) Siderophore-interacting protein PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
GCF_000717245.1	451.50 +- 0.00	1	1	1	0.02 +- 0.00	1	7 PF07690 (1/1) Major Facilitator Superfamily PF04055 (1/1) Radical SAM superfamily PF03466 (1/1) LysR substrate binding domain PF02310 (1/1) B12 binding domain PF00733 (1/1) Asparagine synthase PF00501 (1/1) AMP-binding enzyme PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
GCF_003945525.1	1161.00 +- 0.00	1	0	0	0.01 +- 0.00	1	8 TIGR01187 (1/1) polyamine ABC transporter, ATP-binding protein PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13416 (1/1) Bacterial extracellular solute-binding protein PF09339 (1/1) IclR helix-turn-helix domain PF08402 (1/1) TOBE domain PF04199 (1/1) Putative cyclase PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00005 (1/1) ABC transporter
GCF_001279695.1	493.22 +- 395.49	3	1	1	0.04 +- 0.06	3	1 PF07690 (2/3) Major Facilitator Superfamily
GCF_004000405.1	26.96 +- 0.00	1	0	0	0.07 +- 0.11	1	6 TIGR01525 (1/1) heavy metal translocating P-type ATPase PF04314 (1/1) Copper chaperone PCu(A)C PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase PF00069 (1/1) Protein kinase domain
GCF_003287915.1	355.13 +- 136.45	3	1	0	0.01 +- 0.01	3	No common domains found
GCF_001418415.1	709.50 +- 64.50	2	0	0	0.01 +- 0.00	2	10 TIGR03296 (1/2) M6 family metalloprotease domain PF14759 (1/2) Reductase C-terminal PF13279 (1/2) Thioesterase-like superfamily PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF01613 (1/2) Flavin reductase like domain PF00775 (1/2) Dioxygenase PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain PF00082 (1/2) Subtilase family PF00067 (1/2) Cytochrome P450
GCF_000698495.1	186.43 +- 36.43	2	0	1	0.02 +- 0.01	2	5 PF07690 (2/2) Major Facilitator Superfamily PF13649 (1/2) Methyltransferase domain PF04055 (1/2) Radical SAM superfamily PF03781 (1/2) Sulfatase-modifying factor enzyme 1 PF00884 (1/2) Sulfatase
GCF_003950055.1	702.00 +- 0.00	1	0	0	0.01 +- 0.01	1	9 TIGR00710 (1/1) drug resistance transporter, Bcr/CflA subfamily PF07690 (1/1) Major Facilitator Superfamily PF03737 (1/1) Aldolase/RraA PF03466 (1/1) LysR substrate binding domain PF01361 (1/1) Tautomerase enzyme PF00994 (1/1) Probable molybdopterin binding domain PF00682 (1/1) HMGL-like PF00180 (1/1) Isocitrate/isopropylmalate dehydrogenase PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
GCF_000373625.1	147.43 +- 0.00	1	0	1	0.03 +- 0.01	1	3 PF07702 (1/1) UTRA domain PF04055 (1/1) Radical SAM superfamily PF00392 (1/1) Bacterial regulatory proteins, gntR family
GCF_000720635.1	339.65 +- 407.90	7	1	1	0.03 +- 0.07	7	No common domains found
GCF_001279775.1	127.32 +- 67.68	2	0	0	0.06 +- 0.12	2	23 TIGR00167 (1/2) ketose-bisphosphate aldolase PF17042 (1/2) Nucleotide-binding C-terminal domain PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PF13581 (1/2) Histidine kinase-like ATPase domain PF13407 (1/2) Periplasmic binding protein domain PF13401 (1/2) AAA domain PF13185 (1/2) GAF domain PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252) PF09851 (1/2) Short C-terminal domain PF09339 (1/2) IclR helix-turn-helix domain PF08447 (1/2) PAS fold PF07729 (1/2) FCD domain PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF07005 (1/2) Sugar-binding N-terminal domain PF04203 (1/2) Sortase domain PF03631 (1/2) Virulence factor BrkB PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase PF02447 (1/2) GntP family permease PF01614 (1/2) Bacterial transcriptional regulator PF01116 (1/2) Fructose-bisphosphate aldolase class-II PF00781 (1/2) Diacylglycerol kinase catalytic domain PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00196 (1/2) Bacterial regulatory proteins, luxR family
GCF_001542625.1	1118.45 +- 427.23	4	2	3	0.05 +- 0.16	4	2 PF00005 (3/4) ABC transporter PF00664 (2/4) ABC transporter transmembrane region
GCF_003573485.1	361.59 +- 147.35	5	2	3	0.03 +- 0.10	5	2 PF07690 (3/5) Major Facilitator Superfamily PF04055 (3/5) Radical SAM superfamily
GCF_000331185.1	243.75 +- 113.75	2	1	0	0.03 +- 0.01	2	19 TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB TIGR01733 (1/2) amino acid adenylation domain TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720 TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein PF13732 (1/2) Domain of unknown function (DUF4162) PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12833 (1/2) Helix-turn-helix domain PF03621 (1/2) MbtH-like protein PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF02311 (1/2) AraC-like ligand binding domain PF01061 (1/2) ABC-2 type transporter PF00975 (1/2) Thioesterase domain PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00291 (1/2) Pyridoxal-phosphate dependent enzyme PF00150 (1/2) Cellulase (glycosyl hydrolase family 5) PF00005 (1/2) ABC transporter
GCF_003550235.1	961.81 +- 1674.31	6	3	3	0.03 +- 0.06	6	No common domains found
GCF_003846155.1	314.58 +- 326.85	3	0	0	0.05 +- 0.08	3	No common domains found
GCF_002573955.1	211.02 +- 229.41	3	0	1	0.08 +- 0.14	3	1 PF00534 (2/3) Glycosyl transferases group 1
GCF_000716845.1	131.15 +- 44.17	3	1	1	0.03 +- 0.04	3	No common domains found
GCF_003634815.1	659.57 +- 501.43	2	2	1	0.05 +- 0.11	2	28 PF17676 (1/2) LD-carboxypeptidase C-terminal domain PF13641 (1/2) Glycosyltransferase like family 2 PF13581 (1/2) Histidine kinase-like ATPase domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13280 (1/2) WYL domain PF10823 (1/2) Protein of unknown function (DUF2568) PF09335 (1/2) SNARE associated Golgi protein PF08279 (1/2) HTH domain PF07690 (1/2) Major Facilitator Superfamily PF05977 (1/2) Transmembrane secretion effector PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF04672 (1/2) S-adenosyl methyltransferase PF04055 (1/2) Radical SAM superfamily PF02310 (1/2) B12 binding domain PF02016 (1/2) LD-carboxypeptidase N-terminal domain PF01810 (1/2) LysE type translocator PF01547 (1/2) Bacterial extracellular solute-binding protein PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain PF00925 (1/2) GTP cyclohydrolase II PF00730 (1/2) HhH-GPD superfamily base excision DNA repair protein PF00583 (1/2) Acetyltransferase (GNAT) family PF00400 (1/2) WD domain, G-beta repeat PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00293 (1/2) NUDIX domain PF00152 (1/2) tRNA synthetases class II (D, K and N) PF00067 (1/2) Cytochrome P450 PF00005 (1/2) ABC transporter
GCF_000424805.1	621.11 +- 413.12	3	1	0	0.01 +- 0.00	3	No common domains found
GCF_001905025.1	946.35 +- 1049.91	5	1	1	0.03 +- 0.04	5	No common domains found
GCF_000403665.1	137.00 +- 97.00	2	1	1	0.05 +- 0.04	2	15 TIGR04451 (1/2) lantipeptide, SCO0268 family TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF12802 (1/2) MarR family PF12697 (1/2) Alpha/beta hydrolase family PF11303 (1/2) Protein of unknown function (DUF3105) PF09335 (1/2) SNARE associated Golgi protein PF05147 (1/2) Lanthionine synthetase C-like protein PF04738 (1/2) Lantibiotic dehydratase, N terminus PF02388 (1/2) FemAB family PF02065 (1/2) Melibiase PF01547 (1/2) Bacterial extracellular solute-binding protein PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 PF00480 (1/2) ROK family
GCF_001748305.1	675.20 +- 959.81	5	3	1	0.02 +- 0.03	5	No common domains found
GCF_001723055.1	584.29 +- 0.00	1	0	0	0.01 +- 0.01	1	7 PF13560 (1/1) Helix-turn-helix domain PF13424 (1/1) Tetratricopeptide repeat PF13411 (1/1) MerR HTH family regulatory protein PF10026 (1/1) Predicted Zn-dependent protease (DUF2268) PF08386 (1/1) TAP-like protein PF07739 (1/1) TipAS antibiotic-recognition domain PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
GCF_000764715.1	192.17 +- 107.96	4	2	0	0.03 +- 0.04	4	2 PF07690 (2/4) Major Facilitator Superfamily PF00348 (2/4) Polyprenyl synthetase
GCF_000719555.1	325.00 +- 130.00	2	1	1	0.04 +- 0.02	2	24 TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF13732 (1/2) Domain of unknown function (DUF4162) PF13535 (1/2) ATP-grasp domain PF08443 (1/2) RimK-like ATP-grasp domain PF07690 (1/2) Major Facilitator Superfamily PF05147 (1/2) Lanthionine synthetase C-like protein PF03992 (1/2) Antibiotic biosynthesis monooxygenase PF02779 (1/2) Transketolase, pyrimidine binding domain PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF01546 (1/2) Peptidase family M20/M25/M40 PF01370 (1/2) NAD dependent epimerase/dehydratase family PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF01061 (1/2) ABC-2 type transporter PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (1/2) Amino acid kinase family PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00106 (1/2) short chain dehydrogenase PF00069 (1/2) Protein kinase domain PF00005 (1/2) ABC transporter
GCF_001469455.2	365.24 +- 368.41	3	0	0	0.06 +- 0.16	3	2 PF01636 (2/3) Phosphotransferase enzyme family PF00005 (2/3) ABC transporter
GCF_001279725.1	336.71 +- 263.79	3	1	1	0.04 +- 0.10	3	No common domains found
GCF_000721235.1	252.97 +- 0.00	1	1	1	0.09 +- 0.25	1	11 TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF14867 (1/1) Lantibiotic alpha PF13601 (1/1) Winged helix DNA-binding domain PF13575 (1/1) Domain of unknown function (DUF4135) PF12679 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF04820 (1/1) Tryptophan halogenase PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_001660045.1	43.00 +- 0.00	1	0	0	0.05 +- 0.04	1	2 PF01872 (1/1) RibD C-terminal domain PF00383 (1/1) Cytidine and deoxycytidylate deaminase zinc-binding region
GCF_003721215.1	516.00 +- 0.00	2	0	0	0.01 +- 0.00	2	12 TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 PF12697 (1/2) Alpha/beta hydrolase family PF11706 (1/2) CGNR zinc finger PF07883 (1/2) Cupin domain PF07690 (1/2) Major Facilitator Superfamily PF07336 (1/2) Putative stress-induced transcription regulator PF01613 (1/2) Flavin reductase like domain PF01381 (1/2) Helix-turn-helix PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain PF00239 (1/2) Resolvase, N terminal domain
GCF_001905045.1	796.26 +- 610.92	3	1	1	0.02 +- 0.02	3	1 PF00005 (2/3) ABC transporter
GCF_002080455.1	258.72 +- 14.97	2	1	0	0.06 +- 0.16	2	17 TIGR03797 (1/2) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (1/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein PF13459 (1/2) 4Fe-4S single cluster domain PF13437 (1/2) HlyD family secretion protein PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport PF10589 (1/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF08386 (1/2) TAP-like protein PF07690 (1/2) Major Facilitator Superfamily PF05013 (1/2) N-formylglutamate amidohydrolase PF03640 (1/2) Secreted repeat of unknown function PF03412 (1/2) Peptidase C39 family PF03055 (1/2) Retinal pigment epithelial membrane protein PF01512 (1/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00664 (1/2) ABC transporter transmembrane region PF00561 (1/2) alpha/beta hydrolase fold PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00005 (1/2) ABC transporter
GCF_000974485.1	767.23 +- 830.75	3	2	1	0.01 +- 0.01	3	No common domains found
GCF_000797385.1	1170.00 +- 0.00	1	1	0	0.01 +- 0.00	1	13 TIGR01733 (1/1) amino acid adenylation domain PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13378 (1/1) Enolase C-terminal domain-like PF13193 (1/1) AMP-binding enzyme C-terminal domain PF12146 (1/1) Serine aminopeptidase, S33 PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH) PF03321 (1/1) GH3 auxin-responsive promoter PF02826 (1/1) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF00694 (1/1) Aconitase C-terminal domain PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00330 (1/1) Aconitase family (aconitate hydratase)
GCF_002291145.1	175.87 +- 64.46	3	0	0	0.08 +- 0.14	3	No common domains found
GCF_001632865.1	67.10 +- 0.00	1	0	0	0.06 +- 0.08	1	1 PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
GCF_900114215.1	35.86 +- 0.00	1	0	1	0.06 +- 0.07	1	3 PF13581 (1/1) Histidine kinase-like ATPase domain PF04055 (1/1) Radical SAM superfamily PF01928 (1/1) CYTH domain
GCF_000721685.1	715.00 +- 0.00	1	0	0	0.03 +- 0.01	1	7 PF17914 (1/1) HopA1 effector protein family PF13649 (1/1) Methyltransferase domain PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF00675 (1/1) Insulinase (Peptidase family M16) PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_000958545.1	113.64 +- 58.36	2	1	1	0.05 +- 0.05	2	8 TIGR01910 (1/2) peptidase, ArgE/DapE family PF13471 (1/2) Transglutaminase-like superfamily PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF01546 (1/2) Peptidase family M20/M25/M40 PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF00733 (1/2) Asparagine synthase PF00664 (1/2) ABC transporter transmembrane region PF00005 (1/2) ABC transporter
GCF_001426585.1	726.06 +- 500.77	4	1	2	0.02 +- 0.01	4	1 PF07690 (2/4) Major Facilitator Superfamily
GCF_002846455.1	696.60 +- 0.00	1	1	1	0.01 +- 0.00	1	11 TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03797 (1/1) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (1/1) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein TIGR03605 (1/1) SagB-type dehydrogenase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF13437 (1/1) HlyD family secretion protein PF03412 (1/1) Peptidase C39 family PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (1/1) Nitroreductase family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_002910775.2	462.25 +- 247.25	2	1	0	0.01 +- 0.01	2	14 TIGR00126 (1/2) deoxyribose-phosphate aldolase PF13407 (1/2) Periplasmic binding protein domain PF07702 (1/2) UTRA domain PF06737 (1/2) Transglycosylase-like domain PF05025 (1/2) RbsD / FucU transport protein family PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain PF02653 (1/2) Branched-chain amino acid transport system / permease component PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF01476 (1/2) LysM domain PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00294 (1/2) pfkB family carbohydrate kinase PF00005 (1/2) ABC transporter
GCF_002154275.1	212.47 +- 0.00	1	0	0	0.04 +- 0.05	1	9 TIGR00350 (1/1) cell envelope-related function transcriptional attenuator common domain PF13399 (1/1) LytR cell envelope-related transcriptional attenuator PF07859 (1/1) alpha/beta hydrolase fold PF03816 (1/1) Cell envelope-related transcriptional attenuator domain PF03807 (1/1) NADP oxidoreductase coenzyme F420-dependent PF01258 (1/1) Prokaryotic dksA/traR C4-type zinc finger PF00768 (1/1) D-alanyl-D-alanine carboxypeptidase PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family PF00459 (1/1) Inositol monophosphatase family
GCF_003116755.1	711.34 +- 62.66	2	2	2	0.02 +- 0.03	2	13 PF05147 (2/2) Lanthionine synthetase C-like protein PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM PF14867 (1/2) Lantibiotic alpha PF13575 (1/2) Domain of unknown function (DUF4135) PF13377 (1/2) Periplasmic binding protein-like domain PF12730 (1/2) ABC-2 family transporter protein PF04672 (1/2) S-adenosyl methyltransferase PF03412 (1/2) Peptidase C39 family PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00326 (1/2) Prolyl oligopeptidase family PF00069 (1/2) Protein kinase domain
GCF_001514055.1	463.82 +- 365.79	4	2	0	0.01 +- 0.02	4	No common domains found
GCF_003116775.1	336.52 +- 0.00	1	1	1	0.03 +- 0.03	1	6 PF05147 (1/1) Lanthionine synthetase C-like protein PF04672 (1/1) S-adenosyl methyltransferase PF00664 (1/1) ABC transporter transmembrane region PF00326 (1/1) Prolyl oligopeptidase family PF00069 (1/1) Protein kinase domain PF00005 (1/1) ABC transporter
GCF_001748165.1	282.06 +- 245.26	3	1	0	0.02 +- 0.01	3	2 PF14759 (2/3) Reductase C-terminal PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase
GCF_000411495.1	35.45 +- 0.00	1	0	0	0.08 +- 0.12	1	5 PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (1/1) [2Fe-2S] binding domain PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
GCF_000695235.1	594.27 +- 356.75	6	1	1	0.02 +- 0.02	6	No common domains found
GCF_003116715.1	224.15 +- 85.45	2	1	0	0.04 +- 0.12	2	28 TIGR02124 (1/2) hydrogenase expression/formation protein HypE TIGR01891 (1/2) amidohydrolase TIGR00709 (1/2) 2,4-diaminobutyrate 4-transaminase TIGR00143 (1/2) carbamoyltransferase HypF PF17788 (1/2) HypF Kae1-like domain PF13535 (1/2) ATP-grasp domain PF13374 (1/2) Tetratricopeptide repeat PF13191 (1/2) AAA ATPase domain PF12680 (1/2) SnoaL-like domain PF10502 (1/2) Signal peptidase, peptidase S26 PF07690 (1/2) Major Facilitator Superfamily PF07503 (1/2) HypF finger PF07291 (1/2) Methylamine utilisation protein MauE PF05977 (1/2) Transmembrane secretion effector PF02769 (1/2) AIR synthase related protein, C-terminal domain PF02254 (1/2) TrkA-N domain PF01546 (1/2) Peptidase family M20/M25/M40 PF01300 (1/2) Telomere recombination PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase PF00857 (1/2) Isochorismatase family PF00717 (1/2) Peptidase S24-like PF00708 (1/2) Acylphosphatase PF00664 (1/2) ABC transporter transmembrane region PF00586 (1/2) AIR synthase related protein, N-terminal domain PF00583 (1/2) Acetyltransferase (GNAT) family PF00202 (1/2) Aminotransferase class-III PF00155 (1/2) Aminotransferase class I and II PF00005 (1/2) ABC transporter
GCF_003386845.1	221.43 +- 286.26	4	1	0	0.04 +- 0.08	4	1 PF18085 (2/4) Maltokinase N-terminal cap domain
GCF_004005495.1	191.87 +- 107.74	2	0	0	0.06 +- 0.06	2	25 PF01546 (2/2) Peptidase family M20/M25/M40 TIGR01928 (1/2) o-succinylbenzoate synthase TIGR01910 (1/2) peptidase, ArgE/DapE family TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF13556 (1/2) PucR C-terminal helix-turn-helix domain PF13520 (1/2) Amino acid permease PF13378 (1/2) Enolase C-terminal domain-like PF13354 (1/2) Beta-lactamase enzyme family PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region PF07969 (1/2) Amidohydrolase family PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF07676 (1/2) WD40-like Beta Propeller Repeat PF03061 (1/2) Thioesterase superfamily PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF00743 (1/2) Flavin-binding monooxygenase-like PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00501 (1/2) AMP-binding enzyme PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00326 (1/2) Prolyl oligopeptidase family PF00202 (1/2) Aminotransferase class-III PF00171 (1/2) Aldehyde dehydrogenase family PF00144 (1/2) Beta-lactamase PF00005 (1/2) ABC transporter
GCF_002705975.1	405.43 +- 0.00	1	1	0	0.03 +- 0.03	1	8 PF13416 (1/1) Bacterial extracellular solute-binding protein PF09265 (1/1) Cytokinin dehydrogenase 1, FAD and cytokinin binding PF06236 (1/1) Tyrosinase co-factor MelC1 PF01565 (1/1) FAD binding domain PF01156 (1/1) Inosine-uridine preferring nucleoside hydrolase PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00294 (1/1) pfkB family carbohydrate kinase PF00264 (1/1) Common central domain of tyrosinase
GCF_000590515.1	163.58 +- 75.48	3	0	0	0.05 +- 0.05	3	No common domains found
GCF_002154345.1	268.60 +- 186.69	2	1	1	0.06 +- 0.06	2	12 TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM PF13575 (1/2) Domain of unknown function (DUF4135) PF13411 (1/2) MerR HTH family regulatory protein PF12730 (1/2) ABC-2 family transporter protein PF05147 (1/2) Lanthionine synthetase C-like protein PF03476 (1/2) MOSC N-terminal beta barrel domain PF03473 (1/2) MOSC domain PF03412 (1/2) Peptidase C39 family PF01551 (1/2) Peptidase family M23 PF00664 (1/2) ABC transporter transmembrane region PF00248 (1/2) Aldo/keto reductase family PF00005 (1/2) ABC transporter
GCF_001279855.1	531.82 +- 0.00	1	0	0	0.03 +- 0.01	1	15 TIGR01426 (1/1) glycosyltransferase, MGT family PF17914 (1/1) HopA1 effector protein family PF13692 (1/1) Glycosyl transferases group 1 PF13601 (1/1) Winged helix DNA-binding domain PF12698 (1/1) ABC-2 family transporter protein PF05719 (1/1) Golgi phosphoprotein 3 (GPP34) PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF01636 (1/1) Phosphotransferase enzyme family PF00891 (1/1) O-methyltransferase domain PF00675 (1/1) Insulinase (Peptidase family M16) PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase PF00005 (1/1) ABC transporter
GCF_003663895.1	158.81 +- 2.44	2	0	0	0.05 +- 0.05	2	21 TIGR01766 (1/2) transposase, IS605 OrfB family TIGR01180 (1/2) putative alpha-1,2-mannosidase PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain PF16499 (1/2) Alpha galactosidase A PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic PF07971 (1/2) Glycosyl hydrolase family 92 PF07282 (1/2) Putative transposase DNA-binding domain PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF02057 (1/2) Glycosyl hydrolase family 59 PF01385 (1/2) Probable transposase PF01229 (1/2) Glycosyl hydrolases family 39 PF00672 (1/2) HAMP domain PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00553 (1/2) Cellulose binding domain PF00512 (1/2) His Kinase A (phospho-acceptor) domain PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00331 (1/2) Glycosyl hydrolase family 10 PF00072 (1/2) Response regulator receiver domain
GCF_002155915.1	1548.00 +- 0.00	1	1	1	0.01 +- 0.00	1	9 TIGR04353 (1/1) PqqD family protein, HPr-rel-A system PF13646 (1/1) HEAT repeats PF13471 (1/1) Transglutaminase-like superfamily PF13411 (1/1) MerR HTH family regulatory protein PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (1/1) Asparagine synthase PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_003032475.1	422.69 +- 228.50	3	1	1	0.06 +- 0.16	3	1 PF00005 (2/3) ABC transporter
GCF_002150735.1	405.29 +- 374.71	2	1	1	0.01 +- 0.03	2	12 TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1 TIGR03892 (1/2) thiazolylpeptide-type bacteriocin precursor TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF06821 (1/2) Serine hydrolase PF04738 (1/2) Lantibiotic dehydratase, N terminus PF04055 (1/2) Radical SAM superfamily PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02310 (1/2) B12 binding domain PF00106 (1/2) short chain dehydrogenase
GCF_000377165.1	354.16 +- 244.08	4	2	0	0.05 +- 0.08	4	No common domains found
GCF_000718295.1	71.86 +- 41.63	3	2	1	0.08 +- 0.08	3	No common domains found
GCF_001984575.1	217.69 +- 0.00	1	1	1	0.06 +- 0.07	1	9 TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1 PF12802 (1/1) MarR family PF07690 (1/1) Major Facilitator Superfamily PF04055 (1/1) Radical SAM superfamily PF02310 (1/1) B12 binding domain PF01636 (1/1) Phosphotransferase enzyme family PF00583 (1/1) Acetyltransferase (GNAT) family PF00326 (1/1) Prolyl oligopeptidase family PF00069 (1/1) Protein kinase domain
GCF_001570645.1	239.66 +- 136.25	6	0	0	0.04 +- 0.05	6	1 PF07690 (3/6) Major Facilitator Superfamily
GCF_000720675.1	404.00 +- 238.14	2	0	0	0.03 +- 0.02	2	20 TIGR00928 (1/2) adenylosuccinate lyase TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13673 (1/2) Acetyltransferase (GNAT) domain PF13460 (1/2) NAD(P)H-binding PF12800 (1/2) 4Fe-4S binding domain PF07690 (1/2) Major Facilitator Superfamily PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain PF01814 (1/2) Hemerythrin HHE cation binding domain PF01547 (1/2) Bacterial extracellular solute-binding protein PF01494 (1/2) FAD binding domain PF01425 (1/2) Amidase PF00703 (1/2) Glycosyl hydrolases family 2 PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00561 (1/2) alpha/beta hydrolase fold PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00206 (1/2) Lyase PF00120 (1/2) Glutamine synthetase, catalytic domain PF00072 (1/2) Response regulator receiver domain
GCF_002803845.1	1334.14 +- 511.29	4	3	0	0.01 +- 0.01	4	7 PF13649 (3/4) Methyltransferase domain PF05193 (3/4) Peptidase M16 inactive domain PF00675 (3/4) Insulinase (Peptidase family M16) PF00005 (3/4) ABC transporter PF17914 (2/4) HopA1 effector protein family PF02441 (2/4) Flavoprotein PF01636 (2/4) Phosphotransferase enzyme family
GCF_001279815.1	531.82 +- 0.00	1	0	0	0.03 +- 0.01	1	15 TIGR01426 (1/1) glycosyltransferase, MGT family PF17914 (1/1) HopA1 effector protein family PF13692 (1/1) Glycosyl transferases group 1 PF13601 (1/1) Winged helix DNA-binding domain PF12698 (1/1) ABC-2 family transporter protein PF05719 (1/1) Golgi phosphoprotein 3 (GPP34) PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF01636 (1/1) Phosphotransferase enzyme family PF00891 (1/1) O-methyltransferase domain PF00675 (1/1) Insulinase (Peptidase family M16) PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase PF00005 (1/1) ABC transporter
GCF_001485145.1	140.70 +- 66.23	5	0	1	0.06 +- 0.07	5	No common domains found
GCF_003751985.1	251.55 +- 0.00	1	0	0	0.05 +- 0.01	1	17 PF13193 (1/1) AMP-binding enzyme C-terminal domain PF08386 (1/1) TAP-like protein PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase PF07883 (1/1) Cupin domain PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH) PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain PF01636 (1/1) Phosphotransferase enzyme family PF01593 (1/1) Flavin containing amine oxidoreductase PF01381 (1/1) Helix-turn-helix PF00561 (1/1) alpha/beta hydrolase fold PF00501 (1/1) AMP-binding enzyme PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain PF00202 (1/1) Aminotransferase class-III PF00171 (1/1) Aldehyde dehydrogenase family PF00107 (1/1) Zinc-binding dehydrogenase
GCF_001704275.1	1376.96 +- 1872.70	5	2	0	0.02 +- 0.02	5	No common domains found
GCF_002128305.1	451.50 +- 0.00	1	1	0	0.01 +- 0.00	1	5 TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1 PF08241 (1/1) Methyltransferase domain PF07690 (1/1) Major Facilitator Superfamily PF02310 (1/1) B12 binding domain PF00326 (1/1) Prolyl oligopeptidase family
GCF_000426325.1	97.13 +- 73.68	2	1	1	0.08 +- 0.07	2	11 TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF04738 (1/2) Lantibiotic dehydratase, N terminus PF03704 (1/2) Bacterial transcriptional activator domain PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01145 (1/2) SPFH domain / Band 7 family PF01061 (1/2) ABC-2 type transporter PF00881 (1/2) Nitroreductase family PF00005 (1/2) ABC transporter PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
GCF_000988945.1	196.81 +- 147.19	2	0	0	0.04 +- 0.03	2	14 PF13478 (1/2) XdhC Rossmann domain PF09339 (1/2) IclR helix-turn-helix domain PF07690 (1/2) Major Facilitator Superfamily PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA) PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF02625 (1/2) XdhC and CoxI family PF01799 (1/2) [2Fe-2S] binding domain PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase PF00561 (1/2) alpha/beta hydrolase fold PF00296 (1/2) Luciferase-like monooxygenase PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain PF00106 (1/2) short chain dehydrogenase
GCF_001905785.1	706.54 +- 331.59	3	2	1	0.04 +- 0.06	3	1 PF00005 (3/3) ABC transporter
GCF_003949795.1	65.00 +- 0.00	1	0	0	0.03 +- 0.02	1	3 TIGR03619 (1/1) probable F420-dependent oxidoreductase, Rv2161c family PF01814 (1/1) Hemerythrin HHE cation binding domain PF00296 (1/1) Luciferase-like monooxygenase
GCF_001008135.1	144.48 +- 0.00	1	0	0	0.06 +- 0.06	1	7 PF17900 (1/1) Peptidase M1 N-terminal domain PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain PF02423 (1/1) Ornithine cyclodeaminase/mu-crystallin family PF01965 (1/1) DJ-1/PfpI family PF01433 (1/1) Peptidase family M1 domain PF00440 (1/1) Bacterial regulatory proteins, tetR family PF00082 (1/1) Subtilase family
GCF_003550195.1	184.29 +- 0.00	1	1	1	0.06 +- 0.03	1	13 TIGR04451 (1/1) lantipeptide, SCO0268 family TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF12802 (1/1) MarR family PF12697 (1/1) Alpha/beta hydrolase family PF05147 (1/1) Lanthionine synthetase C-like protein PF04738 (1/1) Lantibiotic dehydratase, N terminus PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain PF02065 (1/1) Melibiase PF01547 (1/1) Bacterial extracellular solute-binding protein PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00480 (1/1) ROK family
GCF_000720645.1	340.31 +- 456.82	4	0	0	0.04 +- 0.05	4	3 PF07690 (2/4) Major Facilitator Superfamily PF00440 (2/4) Bacterial regulatory proteins, tetR family PF00067 (2/4) Cytochrome P450
GCF_900092005.1	686.05 +- 83.95	2	2	2	0.03 +- 0.03	2	13 PF05147 (2/2) Lanthionine synthetase C-like protein PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM PF14867 (1/2) Lantibiotic alpha PF13575 (1/2) Domain of unknown function (DUF4135) PF13377 (1/2) Periplasmic binding protein-like domain PF12730 (1/2) ABC-2 family transporter protein PF04672 (1/2) S-adenosyl methyltransferase PF03412 (1/2) Peptidase C39 family PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00326 (1/2) Prolyl oligopeptidase family PF00069 (1/2) Protein kinase domain
GCF_003024195.1	624.48 +- 646.35	4	2	2	0.05 +- 0.08	4	2 PF07690 (2/4) Major Facilitator Superfamily PF00486 (2/4) Transcriptional regulatory protein, C terminal
GCF_003751175.1	68.76 +- 5.52	2	1	0	0.08 +- 0.04	2	11 TIGR02133 (1/2) ribose 5-phosphate isomerase PF16896 (1/2) Phosphogluconate dehydrogenase (decarboxylating) C-term PF07690 (1/2) Major Facilitator Superfamily PF03992 (1/2) Antibiotic biosynthesis monooxygenase PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent PF02734 (1/2) DAK2 domain PF02733 (1/2) Dak1 domain PF02502 (1/2) Ribose/Galactose Isomerase PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF01261 (1/2) Xylose isomerase-like TIM barrel PF00121 (1/2) Triosephosphate isomerase
GCF_001267885.1	516.00 +- 0.00	1	0	0	0.01 +- 0.00	1	1 PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
GCF_002154675.1	334.55 +- 147.68	3	0	1	0.03 +- 0.07	3	No common domains found
GCF_900215305.1	911.66 +- 731.76	7	1	0	0.02 +- 0.05	7	No common domains found
GCF_004195735.1	161.25 +- 0.00	1	0	0	0.01 +- 0.01	1	5 PF13515 (1/1) Fusaric acid resistance protein-like PF08386 (1/1) TAP-like protein PF01471 (1/1) Putative peptidoglycan binding domain PF00931 (1/1) NB-ARC domain PF00561 (1/1) alpha/beta hydrolase fold
GCF_004195835.1	416.79 +- 0.00	1	1	0	0.10 +- 0.15	1	28 TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (1/1) AMP-binding enzyme C-terminal domain PF10862 (1/1) FcoT-like thioesterase domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08281 (1/1) Sigma-70, region 4 PF07993 (1/1) Male sterility protein PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (1/1) Sigma-70 region 2 PF04314 (1/1) Copper chaperone PCu(A)C PF03929 (1/1) PepSY-associated TM region PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/1) DJ-1/PfpI family PF01794 (1/1) Ferric reductase like transmembrane component PF01497 (1/1) Periplasmic binding protein PF01032 (1/1) FecCD transport family PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase PF00005 (1/1) ABC transporter
GCF_002846295.1	192.12 +- 144.86	5	2	0	0.05 +- 0.16	5	No common domains found
GCF_000385945.1	433.75 +- 32.28	2	2	0	0.06 +- 0.15	2	36 PF00005 (2/2) ABC transporter TIGR01525 (1/2) heavy metal translocating P-type ATPase TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13549 (1/2) ATP-grasp domain PF13535 (1/2) ATP-grasp domain PF13480 (1/2) Acetyltransferase (GNAT) domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF13115 (1/2) YtkA-like PF12697 (1/2) Alpha/beta hydrolase family PF12679 (1/2) ABC-2 family transporter protein PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF04909 (1/2) Amidohydrolase PF04389 (1/2) Peptidase family M28 PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02627 (1/2) Carboxymuconolactone decarboxylase family PF02222 (1/2) ATP-grasp domain PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01676 (1/2) Metalloenzyme superfamily PF01144 (1/2) Coenzyme A transferase PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00664 (1/2) ABC transporter transmembrane region PF00501 (1/2) AMP-binding enzyme PF00403 (1/2) Heavy-metal-associated domain PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00155 (1/2) Aminotransferase class I and II PF00122 (1/2) E1-E2 ATPase PF00117 (1/2) Glutamine amidotransferase class-I PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00106 (1/2) short chain dehydrogenase
GCF_002009175.1	520.00 +- 0.00	1	1	0	0.01 +- 0.00	1	8 PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02780 (1/1) Transketolase, C-terminal domain PF02779 (1/1) Transketolase, pyrimidine binding domain PF00676 (1/1) Dehydrogenase E1 component PF00550 (1/1) Phosphopantetheine attachment site PF00364 (1/1) Biotin-requiring enzyme PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
GCF_002551475.1	1665.00 +- 675.00	2	1	1	0.01 +- 0.00	2	15 PF00005 (2/2) ABC transporter TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM PF17914 (1/2) HopA1 effector protein family PF13649 (1/2) Methyltransferase domain PF13575 (1/2) Domain of unknown function (DUF4135) PF12679 (1/2) ABC-2 family transporter protein PF05193 (1/2) Peptidase M16 inactive domain PF05147 (1/2) Lanthionine synthetase C-like protein PF04978 (1/2) Protein of unknown function (DUF664) PF03412 (1/2) Peptidase C39 family PF02441 (1/2) Flavoprotein PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00296 (1/2) Luciferase-like monooxygenase
GCF_900105695.1	1271.11 +- 0.00	1	0	0	0.01 +- 0.00	1	8 TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region PF02983 (1/1) Alpha-lytic protease prodomain PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle PF00296 (1/1) Luciferase-like monooxygenase PF00089 (1/1) Trypsin PF00005 (1/1) ABC transporter
GCF_000424845.1	127.68 +- 0.00	1	0	0	0.09 +- 0.07	1	7 TIGR01972 (1/1) proton-translocating NADH-quinone oxidoreductase, chain M PF13581 (1/1) Histidine kinase-like ATPase domain PF00507 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 PF00499 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase chain 6 PF00420 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PF00361 (1/1) Proton-conducting membrane transporter PF00146 (1/1) NADH dehydrogenase
GCF_003369795.1	204.75 +- 169.83	2	0	1	0.06 +- 0.10	2	22 TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1 TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF13454 (1/2) FAD-NAD(P)-binding PF12006 (1/2) Protein of unknown function (DUF3500) PF07920 (1/2) Protein of unknown function (DUF1684) PF07690 (1/2) Major Facilitator Superfamily PF06912 (1/2) Protein of unknown function (DUF1275) PF04055 (1/2) Radical SAM superfamily PF03737 (1/2) Aldolase/RraA PF02983 (1/2) Alpha-lytic protease prodomain PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain PF01494 (1/2) FAD binding domain PF01061 (1/2) ABC-2 type transporter PF01019 (1/2) Gamma-glutamyltranspeptidase PF00561 (1/2) alpha/beta hydrolase fold PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00391 (1/2) PEP-utilising enzyme, mobile domain PF00296 (1/2) Luciferase-like monooxygenase PF00160 (1/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PF00155 (1/2) Aminotransferase class I and II PF00089 (1/2) Trypsin PF00005 (1/2) ABC transporter
GCF_000156695.2	668.57 +- 0.00	1	1	1	0.03 +- 0.01	1	8 TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF13575 (1/1) Domain of unknown function (DUF4135) PF12679 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_001485105.1	417.31 +- 63.89	3	1	0	0.05 +- 0.19	3	2 PF00550 (2/3) Phosphopantetheine attachment site PF00501 (2/3) AMP-binding enzyme
GCF_001419685.1	371.73 +- 323.85	3	1	1	0.04 +- 0.03	3	No common domains found
GCF_001983975.1	193.50 +- 0.00	1	0	0	0.02 +- 0.02	1	6 PF14759 (1/1) Reductase C-terminal PF14016 (1/1) Protein of unknown function (DUF4232) PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
GCF_004195845.1	175.38 +- 0.00	1	0	0	0.07 +- 0.11	1	15 TIGR01182 (1/1) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (1/1) Domain of unknown function (DUF4380) PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13407 (1/1) Periplasmic binding protein domain PF13378 (1/1) Enolase C-terminal domain-like PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF07729 (1/1) FCD domain PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (1/1) Branched-chain amino acid transport system / permease component PF01081 (1/1) KDPG and KHG aldolase PF00392 (1/1) Bacterial regulatory proteins, gntR family PF00294 (1/1) pfkB family carbohydrate kinase PF00107 (1/1) Zinc-binding dehydrogenase PF00005 (1/1) ABC transporter
GCF_000719605.1	642.50 +- 832.93	3	1	1	0.04 +- 0.09	3	1 PF07690 (2/3) Major Facilitator Superfamily
GCF_002813165.1	283.02 +- 136.54	4	1	2	0.04 +- 0.06	4	No common domains found
GCF_001905595.1	942.43 +- 998.33	3	2	0	0.04 +- 0.16	3	2 PF00664 (2/3) ABC transporter transmembrane region PF00005 (2/3) ABC transporter
GCF_003116685.1	1955.65 +- 1435.65	2	2	1	0.01 +- 0.03	2	24 TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01733 (1/2) amino acid adenylation domain TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720 PF13203 (1/2) Putative metallopeptidase domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12730 (1/2) ABC-2 family transporter protein PF12697 (1/2) Alpha/beta hydrolase family PF09967 (1/2) VWA-like domain (DUF2201) PF08242 (1/2) Methyltransferase domain PF07730 (1/2) Histidine kinase PF07728 (1/2) AAA domain (dynein-related subfamily) PF06722 (1/2) Protein of unknown function (DUF1205) PF03621 (1/2) MbtH-like protein PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00975 (1/2) Thioesterase domain PF00668 (1/2) Condensation domain PF00664 (1/2) ABC transporter transmembrane region PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00072 (1/2) Response regulator receiver domain PF00005 (1/2) ABC transporter
GCF_001279345.1	759.18 +- 1395.80	7	4	2	0.05 +- 0.13	7	No common domains found
GCF_000738695.1	392.10 +- 367.46	6	2	1	0.04 +- 0.15	6	No common domains found
GCF_000716745.1	124.03 +- 35.65	3	1	1	0.03 +- 0.02	3	No common domains found
GCF_000717965.1	241.43 +- 0.00	1	0	0	0.02 +- 0.01	1	10 TIGR03930 (1/1) WXG100 family type VII secretion target TIGR03920 (1/1) type VII secretion integral membrane protein EccD TIGR03919 (1/1) type VII secretion protein EccB PF15644 (1/1) Papain fold toxin 1, glutamine deamidase PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD PF07179 (1/1) SseB protein N-terminal domain PF06013 (1/1) Proteins of 100 residues with WXG PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B PF02575 (1/1) YbaB/EbfC DNA-binding family PF00652 (1/1) Ricin-type beta-trefoil lectin domain
GCF_000709915.1	23.11 +- 0.00	1	0	0	0.09 +- 0.08	1	2 PF13714 (1/1) Phosphoenolpyruvate phosphomutase PF03713 (1/1) Domain of unknown function (DUF305)
GCF_003955715.1	532.12 +- 467.62	2	0	1	0.05 +- 0.17	2	30 TIGR04364 (1/2) methyltransferase, FxLD system TIGR04363 (1/2) FxLD family lantipeptide TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF13649 (1/2) Methyltransferase domain PF13581 (1/2) Histidine kinase-like ATPase domain PF12006 (1/2) Protein of unknown function (DUF3500) PF05331 (1/2) Protein of unknown function (DUF742) PF05147 (1/2) Lanthionine synthetase C-like protein PF04851 (1/2) Type III restriction enzyme, res subunit PF04738 (1/2) Lantibiotic dehydratase, N terminus PF04672 (1/2) S-adenosyl methyltransferase PF03457 (1/2) Helicase associated domain PF03259 (1/2) Roadblock/LC7 domain PF03029 (1/2) Conserved hypothetical ATP binding protein PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF01636 (1/2) Phosphotransferase enzyme family PF01590 (1/2) GAF domain PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00672 (1/2) HAMP domain PF00512 (1/2) His Kinase A (phospho-acceptor) domain PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00293 (1/2) NUDIX domain PF00271 (1/2) Helicase conserved C-terminal domain PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00072 (1/2) Response regulator receiver domain PF00005 (1/2) ABC transporter
GCF_003261055.1	214.50 +- 171.99	5	1	1	0.05 +- 0.08	5	No common domains found
GCF_000721365.1	1554.07 +- 2002.71	3	0	0	0.03 +- 0.04	3	1 PF00005 (2/3) ABC transporter
GCF_002754715.1	14352.00 +- 0.00	1	1	1	0.01 +- 0.00	1	21 TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/1) SagB-type dehydrogenase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01891 (1/1) amidohydrolase PF14310 (1/1) Fibronectin type III-like domain PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF07730 (1/1) Histidine kinase PF04738 (1/1) Lantibiotic dehydratase, N terminus PF03412 (1/1) Peptidase C39 family PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01915 (1/1) Glycosyl hydrolase family 3 C-terminal domain PF01546 (1/1) Peptidase family M20/M25/M40 PF01061 (1/1) ABC-2 type transporter PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain PF00881 (1/1) Nitroreductase family PF00664 (1/1) ABC transporter transmembrane region PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00072 (1/1) Response regulator receiver domain PF00067 (1/1) Cytochrome P450 PF00005 (1/1) ABC transporter
GCF_004295505.1	128.95 +- 73.67	2	0	1	0.09 +- 0.07	2	25 TIGR01733 (1/2) amino acid adenylation domain PF18029 (1/2) Glyoxalase-like domain PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF14765 (1/2) Polyketide synthase dehydratase PF13471 (1/2) Transglutaminase-like superfamily PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08713 (1/2) DNA alkylation repair enzyme PF08659 (1/2) KR domain PF07690 (1/2) Major Facilitator Superfamily PF07478 (1/2) D-ala D-ala ligase C-terminus PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF01820 (1/2) D-ala D-ala ligase N-terminus PF01494 (1/2) FAD binding domain PF00975 (1/2) Thioesterase domain PF00850 (1/2) Histone deacetylase domain PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain) PF00733 (1/2) Asparagine synthase PF00698 (1/2) Acyl transferase domain PF00551 (1/2) Formyl transferase PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00355 (1/2) Rieske [2Fe-2S] domain PF00155 (1/2) Aminotransferase class I and II PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
GCF_900091985.1	300.26 +- 323.57	5	2	0	0.05 +- 0.16	5	1 PF07690 (3/5) Major Facilitator Superfamily
GCF_001514265.1	572.85 +- 77.15	2	0	0	0.04 +- 0.11	2	30 PF07690 (2/2) Major Facilitator Superfamily PF00326 (2/2) Prolyl oligopeptidase family TIGR03567 (1/2) FMN reductase TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family TIGR01484 (1/2) HAD hydrolase, family IIB PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain PF14559 (1/2) Tetratricopeptide repeat PF13535 (1/2) ATP-grasp domain PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring) PF13432 (1/2) Tetratricopeptide repeat PF13424 (1/2) Tetratricopeptide repeat PF09334 (1/2) tRNA synthetases class I (M) PF08282 (1/2) haloacid dehalogenase-like hydrolase PF08281 (1/2) Sigma-70, region 4 PF07883 (1/2) Cupin domain PF04542 (1/2) Sigma-70 region 2 PF03358 (1/2) NADPH-dependent FMN reductase PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02142 (1/2) MGS-like domain PF01808 (1/2) AICARFT/IMPCHase bienzyme PF01613 (1/2) Flavin reductase like domain PF01259 (1/2) SAICAR synthetase PF00709 (1/2) Adenylosuccinate synthetase PF00355 (1/2) Rieske [2Fe-2S] domain PF00294 (1/2) pfkB family carbohydrate kinase PF00202 (1/2) Aminotransferase class-III PF00106 (1/2) short chain dehydrogenase
GCF_003112515.1	480.00 +- 0.00	1	0	0	0.01 +- 0.00	1	8 TIGR03930 (1/1) WXG100 family type VII secretion target TIGR03920 (1/1) type VII secretion integral membrane protein EccD TIGR03919 (1/1) type VII secretion protein EccB PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD PF06013 (1/1) Proteins of 100 residues with WXG PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B PF02575 (1/1) YbaB/EbfC DNA-binding family PF00652 (1/1) Ricin-type beta-trefoil lectin domain
GCF_001279805.1	387.00 +- 0.00	1	0	1	0.01 +- 0.00	1	10 TIGR03822 (1/1) lysine-2,3-aminomutase-related protein PF18604 (1/1) Pre ATP-grasp domain PF18105 (1/1) PGM1 C-terminal domain PF13649 (1/1) Methyltransferase domain PF13480 (1/1) Acetyltransferase (GNAT) domain PF12697 (1/1) Alpha/beta hydrolase family PF12544 (1/1) Lysine-2,3-aminomutase PF07690 (1/1) Major Facilitator Superfamily PF04055 (1/1) Radical SAM superfamily PF00144 (1/1) Beta-lactamase
GCF_000719865.1	738.95 +- 0.00	1	1	1	0.01 +- 0.00	1	9 TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1 PF13649 (1/1) Methyltransferase domain PF07690 (1/1) Major Facilitator Superfamily PF05193 (1/1) Peptidase M16 inactive domain PF04989 (1/1) Cephalosporin hydroxylase PF04055 (1/1) Radical SAM superfamily PF02310 (1/1) B12 binding domain PF00805 (1/1) Pentapeptide repeats (8 copies) PF00675 (1/1) Insulinase (Peptidase family M16)
GCF_003143855.1	1020.39 +- 895.05	3	0	0	0.03 +- 0.09	3	2 PF00775 (2/3) Dioxygenase PF00378 (2/3) Enoyl-CoA hydratase/isomerase
GCF_000738715.1	672.64 +- 617.36	2	0	0	0.02 +- 0.04	2	12 TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083 PF13407 (1/2) Periplasmic binding protein domain PF13377 (1/2) Periplasmic binding protein-like domain PF13302 (1/2) Acetyltransferase (GNAT) domain PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF05025 (1/2) RbsD / FucU transport protein family PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02036 (1/2) SCP-2 sterol transfer family PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00294 (1/2) pfkB family carbohydrate kinase PF00005 (1/2) ABC transporter
GCF_003846255.1	487.50 +- 0.00	1	1	1	0.02 +- 0.02	1	6 PF05147 (1/1) Lanthionine synthetase C-like protein PF04672 (1/1) S-adenosyl methyltransferase PF00664 (1/1) ABC transporter transmembrane region PF00326 (1/1) Prolyl oligopeptidase family PF00069 (1/1) Protein kinase domain PF00005 (1/1) ABC transporter
GCF_002551335.1	52.30 +- 0.00	1	0	0	0.10 +- 0.10	1	2 PF17964 (1/1) Bacterial Ig domain PF03734 (1/1) L,D-transpeptidase catalytic domain
GCF_900105525.1	306.56 +- 112.53	4	2	1	0.04 +- 0.17	4	3 PF07690 (3/4) Major Facilitator Superfamily PF00535 (2/4) Glycosyl transferase family 2 PF00196 (2/4) Bacterial regulatory proteins, luxR family
GCF_003146615.1	279.00 +- 186.14	2	0	1	0.06 +- 0.09	2	16 PF00005 (2/2) ABC transporter TIGR00976 (1/2) hydrolase CocE/NonD family protein PF12450 (1/2) von Willebrand factor PF12034 (1/2) Domain of unknown function (DUF3520) PF10502 (1/2) Signal peptidase, peptidase S26 PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07291 (1/2) Methylamine utilisation protein MauE PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01497 (1/2) Periplasmic binding protein PF01032 (1/2) FecCD transport family PF00717 (1/2) Peptidase S24-like PF00664 (1/2) ABC transporter transmembrane region PF00501 (1/2) AMP-binding enzyme PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00092 (1/2) von Willebrand factor type A domain
GCF_003949845.1	1027.12 +- 1027.69	6	2	3	0.01 +- 0.01	6	1 PF07690 (3/6) Major Facilitator Superfamily
GCF_000720725.1	241.83 +- 220.09	6	0	2	0.06 +- 0.10	6	No common domains found
GCF_001418625.1	438.94 +- 287.53	2	1	0	0.07 +- 0.19	2	28 TIGR01525 (1/2) heavy metal translocating P-type ATPase TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) TIGR00218 (1/2) mannose-6-phosphate isomerase, class I PF13549 (1/2) ATP-grasp domain PF13535 (1/2) ATP-grasp domain PF13480 (1/2) Acetyltransferase (GNAT) domain PF13377 (1/2) Periplasmic binding protein-like domain PF13115 (1/2) YtkA-like PF12697 (1/2) Alpha/beta hydrolase family PF04389 (1/2) Peptidase family M28 PF02627 (1/2) Carboxymuconolactone decarboxylase family PF02222 (1/2) ATP-grasp domain PF01676 (1/2) Metalloenzyme superfamily PF01547 (1/2) Bacterial extracellular solute-binding protein PF01238 (1/2) Phosphomannose isomerase type I PF00703 (1/2) Glycosyl hydrolases family 2 PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00664 (1/2) ABC transporter transmembrane region PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00403 (1/2) Heavy-metal-associated domain PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00155 (1/2) Aminotransferase class I and II PF00150 (1/2) Cellulase (glycosyl hydrolase family 5) PF00122 (1/2) E1-E2 ATPase PF00117 (1/2) Glutamine amidotransferase class-I PF00005 (1/2) ABC transporter
GCF_001550215.1	75.82 +- 32.82	2	0	0	0.09 +- 0.14	2	14 TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083 PF13407 (1/2) Periplasmic binding protein domain PF13377 (1/2) Periplasmic binding protein-like domain PF13302 (1/2) Acetyltransferase (GNAT) domain PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF02036 (1/2) SCP-2 sterol transfer family PF00430 (1/2) ATP synthase B/B' CF(0) PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00294 (1/2) pfkB family carbohydrate kinase PF00005 (1/2) ABC transporter
GCF_000719575.1	448.72 +- 157.48	6	0	0	0.03 +- 0.08	6	1 PF00528 (3/6) Binding-protein-dependent transport system inner membrane component
GCF_001514065.1	287.48 +- 226.00	3	0	0	0.03 +- 0.07	3	No common domains found
GCF_000718375.1	98.11 +- 0.00	1	0	0	0.04 +- 0.03	1	8 TIGR03930 (1/1) WXG100 family type VII secretion target TIGR03920 (1/1) type VII secretion integral membrane protein EccD TIGR03919 (1/1) type VII secretion protein EccB PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD PF07179 (1/1) SseB protein N-terminal domain PF06013 (1/1) Proteins of 100 residues with WXG PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B PF02575 (1/1) YbaB/EbfC DNA-binding family
GCF_003443735.1	506.67 +- 561.21	3	1	1	0.02 +- 0.02	3	No common domains found
GCF_000720835.1	390.00 +- 0.00	1	0	0	0.01 +- 0.00	1	4 PF02737 (1/1) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF01613 (1/1) Flavin reductase like domain PF00725 (1/1) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00296 (1/1) Luciferase-like monooxygenase
GCF_002382885.1	699.69 +- 118.21	3	2	1	0.04 +- 0.06	3	1 PF00005 (2/3) ABC transporter
GCF_900110255.1	101.74 +- 0.00	1	0	0	0.04 +- 0.08	1	9 PF18130 (1/1) ATP-grasp N-terminal domain PF16259 (1/1) Domain of unknown function (DUF4913) PF13620 (1/1) Carboxypeptidase regulatory-like domain PF13535 (1/1) ATP-grasp domain PF12307 (1/1) Protein of unknown function (DUF3631) PF07690 (1/1) Major Facilitator Superfamily PF03771 (1/1) Domain of unknown function (DUF317) PF01638 (1/1) HxlR-like helix-turn-helix PF01555 (1/1) DNA methylase
GCF_003846265.1	218.20 +- 39.80	2	1	1	0.05 +- 0.07	2	16 TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/2) SagB-type dehydrogenase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF13191 (1/2) AAA ATPase domain PF04738 (1/2) Lantibiotic dehydratase, N terminus PF03704 (1/2) Bacterial transcriptional activator domain PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase PF01145 (1/2) SPFH domain / Band 7 family PF01061 (1/2) ABC-2 type transporter PF00881 (1/2) Nitroreductase family PF00877 (1/2) NlpC/P60 family PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00005 (1/2) ABC transporter
GCF_004217355.1	89.58 +- 0.00	1	1	0	0.06 +- 0.05	1	5 PF17900 (1/1) Peptidase M1 N-terminal domain PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase PF01433 (1/1) Peptidase family M1 domain PF00583 (1/1) Acetyltransferase (GNAT) family PF00293 (1/1) NUDIX domain
GCF_003073355.1	650.00 +- 455.00	2	0	0	0.02 +- 0.00	2	23 TIGR00229 (1/2) PAS domain S-box protein PF17148 (1/2) Domain of unknown function (DUF5117) PF16353 (1/2) Domain of unknown function(DUF4981) PF16313 (1/2) Met-zincin PF13581 (1/2) Histidine kinase-like ATPase domain PF13426 (1/2) PAS domain PF13378 (1/2) Enolase C-terminal domain-like PF13377 (1/2) Periplasmic binding protein-like domain PF13185 (1/2) GAF domain PF08448 (1/2) PAS fold PF07702 (1/2) UTRA domain PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF06452 (1/2) Carbohydrate family 9 binding domain-like PF02929 (1/2) Beta galactosidase small chain PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02065 (1/2) Melibiase PF01547 (1/2) Bacterial extracellular solute-binding protein PF01370 (1/2) NAD dependent epimerase/dehydratase family PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00356 (1/2) Bacterial regulatory proteins, lacI family
GCF_002189675.2	474.78 +- 305.22	2	1	0	0.02 +- 0.00	2	19 TIGR01490 (1/2) HAD hydrolase, family IB PF12710 (1/2) haloacid dehalogenase-like hydrolase PF07690 (1/2) Major Facilitator Superfamily PF03756 (1/2) A-factor biosynthesis hotdog domain PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF01937 (1/2) Protein of unknown function DUF89 PF01494 (1/2) FAD binding domain PF01370 (1/2) NAD dependent epimerase/dehydratase family PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01061 (1/2) ABC-2 type transporter PF00975 (1/2) Thioesterase domain PF00891 (1/2) O-methyltransferase domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00391 (1/2) PEP-utilising enzyme, mobile domain PF00300 (1/2) Histidine phosphatase superfamily (branch 1) PF00248 (1/2) Aldo/keto reductase family PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00004 (1/2) ATPase family associated with various cellular activities (AAA)
GCF_001509775.1	146.27 +- 8.62	2	0	0	0.06 +- 0.08	2	18 TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family TIGR00976 (1/2) hydrolase CocE/NonD family protein TIGR00350 (1/2) cell envelope-related function transcriptional attenuator common domain PF13399 (1/2) LytR cell envelope-related transcriptional attenuator PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF03816 (1/2) Cell envelope-related transcriptional attenuator domain PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01258 (1/2) Prokaryotic dksA/traR C4-type zinc finger PF01244 (1/2) Membrane dipeptidase (Peptidase family M19) PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase PF00583 (1/2) Acetyltransferase (GNAT) family PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3 PF00459 (1/2) Inositol monophosphatase family PF00005 (1/2) ABC transporter
GCF_001280885.1	43.00 +- 0.00	1	1	0	0.05 +- 0.04	1	3 PF02868 (1/1) Thermolysin metallopeptidase, alpha-helical domain PF01447 (1/1) Thermolysin metallopeptidase, catalytic domain PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
GCF_003989035.1	650.72 +- 656.33	3	1	1	0.03 +- 0.06	3	1 PF00005 (2/3) ABC transporter
GCF_002005565.1	2882.61 +- 0.00	1	1	0	0.01 +- 0.01	1	16 TIGR01830 (1/1) 3-oxoacyl-[acyl-carrier-protein] reductase TIGR01733 (1/1) amino acid adenylation domain TIGR01720 (1/1) non-ribosomal peptide synthase domain TIGR01720 PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13279 (1/1) Thioesterase-like superfamily PF13193 (1/1) AMP-binding enzyme C-terminal domain PF12146 (1/1) Serine aminopeptidase, S33 PF07977 (1/1) FabA-like domain PF07508 (1/1) Recombinase PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain PF01323 (1/1) DSBA-like thioredoxin domain PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
GCF_000725705.1	134.43 +- 171.14	4	1	0	0.07 +- 0.17	4	1 PF00082 (2/4) Subtilase family
GCF_002114065.1	321.24 +- 0.00	1	1	0	0.10 +- 0.22	1	26 TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00802 (1/1) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III PF14237 (1/1) GYF domain 2 PF13421 (1/1) SPFH domain-Band 7 family PF13193 (1/1) AMP-binding enzyme C-terminal domain PF10862 (1/1) FcoT-like thioesterase domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08281 (1/1) Sigma-70, region 4 PF07993 (1/1) Male sterility protein PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (1/1) Sigma-70 region 2 PF04314 (1/1) Copper chaperone PCu(A)C PF03824 (1/1) High-affinity nickel-transport protein PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase
GCF_002920575.1	53.77 +- 24.23	2	0	0	0.05 +- 0.09	2	7 PF14759 (1/2) Reductase C-terminal PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF07883 (1/2) Cupin domain PF01381 (1/2) Helix-turn-helix PF00583 (1/2) Acetyltransferase (GNAT) family PF00355 (1/2) Rieske [2Fe-2S] domain PF00083 (1/2) Sugar (and other) transporter
GCF_000721155.1	73.80 +- 12.86	2	1	1	0.06 +- 0.06	2	12 PF14158 (1/2) YndJ-like protein PF13581 (1/2) Histidine kinase-like ATPase domain PF13492 (1/2) GAF domain PF13471 (1/2) Transglutaminase-like superfamily PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF09348 (1/2) Domain of unknown function (DUF1990) PF08447 (1/2) PAS fold PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase PF00733 (1/2) Asparagine synthase PF00149 (1/2) Calcineurin-like phosphoesterase
GCF_001905665.1	151.67 +- 0.00	1	1	1	0.02 +- 0.01	1	4 PF07690 (1/1) Major Facilitator Superfamily PF04055 (1/1) Radical SAM superfamily PF02897 (1/1) Prolyl oligopeptidase, N-terminal beta-propeller domain PF00326 (1/1) Prolyl oligopeptidase family
GCF_000717655.1	80.29 +- 11.47	2	1	0	0.04 +- 0.04	2	7 TIGR03296 (1/2) M6 family metalloprotease domain PF13649 (1/2) Methyltransferase domain PF06737 (1/2) Transglycosylase-like domain PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00561 (1/2) alpha/beta hydrolase fold
GCF_001509795.1	230.00 +- 160.00	2	0	0	0.04 +- 0.04	2	15 PF00082 (2/2) Subtilase family TIGR03921 (1/2) type VII secretion-associated serine protease mycosin PF13191 (1/2) AAA ATPase domain PF07729 (1/2) FCD domain PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif PF05345 (1/2) Putative Ig domain PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain PF02225 (1/2) PA domain PF01638 (1/2) HxlR-like helix-turn-helix PF01483 (1/2) Proprotein convertase P-domain PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00293 (1/2) NUDIX domain PF00221 (1/2) Aromatic amino acid lyase PF00196 (1/2) Bacterial regulatory proteins, luxR family
GCF_002939475.1	516.00 +- 0.00	1	1	1	0.01 +- 0.00	1	7 TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain TIGR03558 (1/1) luciferase family oxidoreductase, group 1 PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF05147 (1/1) Lanthionine synthetase C-like protein PF04738 (1/1) Lantibiotic dehydratase, N terminus PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_003751325.1	409.88 +- 324.50	4	1	1	0.04 +- 0.07	4	1 PF00005 (2/4) ABC transporter
GCF_002192455.1	534.60 +- 431.67	3	3	1	0.02 +- 0.02	3	1 PF00005 (2/3) ABC transporter
GCF_004196035.1	76.10 +- 0.00	1	1	0	0.05 +- 0.00	1	12 TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain PF18130 (1/1) ATP-grasp N-terminal domain PF13640 (1/1) 2OG-Fe(II) oxygenase superfamily PF13535 (1/1) ATP-grasp domain PF13193 (1/1) AMP-binding enzyme C-terminal domain PF07993 (1/1) Male sterility protein PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00106 (1/1) short chain dehydrogenase
GCF_002920535.1	234.00 +- 0.00	1	0	0	0.01 +- 0.01	1	4 PF07690 (1/1) Major Facilitator Superfamily PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH) PF01266 (1/1) FAD dependent oxidoreductase PF00474 (1/1) Sodium:solute symporter family
GCF_001047325.1	559.00 +- 351.00	2	1	0	0.02 +- 0.02	2	31 TIGR03425 (1/2) urea carboxylase-associated protein 2 TIGR03424 (1/2) urea carboxylase-associated protein 1 TIGR02712 (1/2) urea carboxylase TIGR01930 (1/2) acetyl-CoA C-acyltransferase TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF13535 (1/2) ATP-grasp domain PF13520 (1/2) Amino acid permease PF13419 (1/2) Haloacid dehalogenase-like hydrolase PF13394 (1/2) 4Fe-4S single cluster domain PF09347 (1/2) Domain of unknown function (DUF1989) PF07690 (1/2) Major Facilitator Superfamily PF06508 (1/2) Queuosine biosynthesis protein QueC PF06368 (1/2) Methylaspartate mutase E chain (MutE) PF02803 (1/2) Thiolase, C-terminal domain PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain PF02785 (1/2) Biotin carboxylase C-terminal domain PF02682 (1/2) Carboxyltransferase domain, subdomain C and D PF02626 (1/2) Carboxyltransferase domain, subdomain A and B PF02310 (1/2) B12 binding domain PF01425 (1/2) Amidase PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase PF01227 (1/2) GTP cyclohydrolase I PF00668 (1/2) Condensation domain PF00501 (1/2) AMP-binding enzyme PF00487 (1/2) Fatty acid desaturase PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00364 (1/2) Biotin-requiring enzyme PF00289 (1/2) Biotin carboxylase, N-terminal domain PF00108 (1/2) Thiolase, N-terminal domain
GCF_001700515.1	845.00 +- 0.00	1	0	0	0.01 +- 0.01	1	8 PF13400 (1/1) Putative Flp pilus-assembly TadE/G-like PF07730 (1/1) Histidine kinase PF07591 (1/1) Pretoxin HINT domain PF01636 (1/1) Phosphotransferase enzyme family PF00691 (1/1) OmpA family PF00482 (1/1) Type II secretion system (T2SS), protein F PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00072 (1/1) Response regulator receiver domain
GCF_000424765.1	614.55 +- 0.00	1	1	1	0.08 +- 0.24	1	8 TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (1/1) ABC-2 type transporter PF00881 (1/1) Nitroreductase family PF00005 (1/1) ABC transporter
GCF_000721175.1	218.17 +- 133.41	3	1	1	0.03 +- 0.04	3	No common domains found
GCF_001905795.1	99.13 +- 4.07	2	0	0	0.05 +- 0.04	2	13 TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating) PF13621 (1/2) Cupin-like domain PF12740 (1/2) Chlorophyllase enzyme PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF07836 (1/2) DmpG-like communication domain PF07690 (1/2) Major Facilitator Superfamily PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00682 (1/2) HMGL-like PF00155 (1/2) Aminotransferase class I and II PF00135 (1/2) Carboxylesterase family
GCF_000719695.1	612.37 +- 199.48	5	3	2	0.05 +- 0.17	5	1 PF00528 (3/5) Binding-protein-dependent transport system inner membrane component
GCF_002754435.1	292.86 +- 107.14	2	1	1	0.04 +- 0.05	2	13 PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain PF12697 (1/2) Alpha/beta hydrolase family PF08386 (1/2) TAP-like protein PF05532 (1/2) CsbD-like PF05147 (1/2) Lanthionine synthetase C-like protein PF03992 (1/2) Antibiotic biosynthesis monooxygenase PF00561 (1/2) alpha/beta hydrolase fold PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00248 (1/2) Aldo/keto reductase family PF00117 (1/2) Glutamine amidotransferase class-I PF00069 (1/2) Protein kinase domain
GCF_001509785.1	347.82 +- 313.55	3	0	0	0.03 +- 0.05	3	1 PF00082 (3/3) Subtilase family
GCF_002335465.1	67.60 +- 36.23	2	1	0	0.09 +- 0.12	2	23 TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (1/2) amino acid adenylation domain PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF13796 (1/2) Putative sensor PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12158 (1/2) Protein of unknown function (DUF3592) PF07730 (1/2) Histidine kinase PF07690 (1/2) Major Facilitator Superfamily PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18) PF01874 (1/2) ATP:dephospho-CoA triphosphoribosyl transferase PF00975 (1/2) Thioesterase domain PF00877 (1/2) NlpC/P60 family PF00775 (1/2) Dioxygenase PF00698 (1/2) Acyl transferase domain PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00296 (1/2) Luciferase-like monooxygenase PF00202 (1/2) Aminotransferase class-III PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
GCF_001418645.1	143.27 +- 0.00	1	0	0	0.06 +- 0.03	1	5 PF04143 (1/1) Sulphur transport PF03466 (1/1) LysR substrate binding domain PF03328 (1/1) HpcH/HpaI aldolase/citrate lyase family PF02515 (1/1) CoA-transferase family III PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
GCF_002551135.1	624.12 +- 155.88	2	2	1	0.06 +- 0.07	2	37 PF00005 (2/2) ABC transporter TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM TIGR01746 (1/2) thioester reductase domain TIGR01733 (1/2) amino acid adenylation domain TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR01525 (1/2) heavy metal translocating P-type ATPase TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF13575 (1/2) Domain of unknown function (DUF4135) PF13535 (1/2) ATP-grasp domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12679 (1/2) ABC-2 family transporter protein PF10862 (1/2) FcoT-like thioesterase domain PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region PF07993 (1/2) Male sterility protein PF07690 (1/2) Major Facilitator Superfamily PF05147 (1/2) Lanthionine synthetase C-like protein PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase PF04978 (1/2) Protein of unknown function (DUF664) PF04314 (1/2) Copper chaperone PCu(A)C PF03412 (1/2) Peptidase C39 family PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/2) DJ-1/PfpI family PF01497 (1/2) Periplasmic binding protein PF01032 (1/2) FecCD transport family PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00668 (1/2) Condensation domain PF00664 (1/2) ABC transporter transmembrane region PF00550 (1/2) Phosphopantetheine attachment site PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00501 (1/2) AMP-binding enzyme PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00403 (1/2) Heavy-metal-associated domain PF00122 (1/2) E1-E2 ATPase
GCF_000717665.1	148.21 +- 103.34	2	0	0	0.04 +- 0.04	2	14 TIGR03930 (1/2) WXG100 family type VII secretion target TIGR03920 (1/2) type VII secretion integral membrane protein EccD TIGR03919 (1/2) type VII secretion protein EccB TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family PF15644 (1/2) Papain fold toxin 1, glutamine deamidase PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD PF07690 (1/2) Major Facilitator Superfamily PF07179 (1/2) SseB protein N-terminal domain PF06013 (1/2) Proteins of 100 residues with WXG PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B PF02575 (1/2) YbaB/EbfC DNA-binding family PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00296 (1/2) Luciferase-like monooxygenase PF00106 (1/2) short chain dehydrogenase
GCF_002551375.1	678.68 +- 350.25	3	2	2	0.02 +- 0.01	3	3 PF00005 (3/3) ABC transporter PF05147 (2/3) Lanthionine synthetase C-like protein PF00664 (2/3) ABC transporter transmembrane region
GCF_002551185.1	53.75 +- 0.00	1	1	0	0.09 +- 0.10	1	5 PF03551 (1/1) Transcriptional regulator PadR-like family PF00975 (1/1) Thioesterase domain PF00501 (1/1) AMP-binding enzyme PF00248 (1/1) Aldo/keto reductase family PF00067 (1/1) Cytochrome P450
GCF_002154555.1	265.59 +- 0.00	1	0	0	0.04 +- 0.07	1	14 TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00802 (1/1) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family PF14237 (1/1) GYF domain 2 PF13421 (1/1) SPFH domain-Band 7 family PF08281 (1/1) Sigma-70, region 4 PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (1/1) Sigma-70 region 2 PF04314 (1/1) Copper chaperone PCu(A)C PF03824 (1/1) High-affinity nickel-transport protein PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase
GCF_004078575.1	197.15 +- 0.00	1	1	0	0.09 +- 0.10	1	24 TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (1/1) AMP-binding enzyme C-terminal domain PF10862 (1/1) FcoT-like thioesterase domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (1/1) Male sterility protein PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (1/1) Copper chaperone PCu(A)C PF03929 (1/1) PepSY-associated TM region PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/1) DJ-1/PfpI family PF01497 (1/1) Periplasmic binding protein PF01032 (1/1) FecCD transport family PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase PF00005 (1/1) ABC transporter
GCF_000720685.1	91.45 +- 44.83	4	1	1	0.05 +- 0.05	4	No common domains found
GCF_000702365.1	1235.00 +- 585.00	2	2	2	0.01 +- 0.01	2	11 PF05147 (2/2) Lanthionine synthetase C-like protein PF00664 (2/2) ABC transporter transmembrane region PF00005 (2/2) ABC transporter TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM PF14867 (1/2) Lantibiotic alpha PF13575 (1/2) Domain of unknown function (DUF4135) PF12730 (1/2) ABC-2 family transporter protein PF04672 (1/2) S-adenosyl methyltransferase PF03412 (1/2) Peptidase C39 family PF00326 (1/2) Prolyl oligopeptidase family PF00069 (1/2) Protein kinase domain
GCF_000716875.1	405.43 +- 368.57	2	0	1	0.03 +- 0.03	2	9 TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain PF13186 (1/2) Iron-sulfur cluster-binding domain PF08007 (1/2) Cupin superfamily protein PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF04055 (1/2) Radical SAM superfamily PF01061 (1/2) ABC-2 type transporter PF00717 (1/2) Peptidase S24-like PF00248 (1/2) Aldo/keto reductase family PF00005 (1/2) ABC transporter
GCF_003129505.1	74.29 +- 0.00	1	0	0	0.04 +- 0.04	1	5 PF13602 (1/1) Zinc-binding dehydrogenase PF13564 (1/1) DoxX-like family PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF00296 (1/1) Luciferase-like monooxygenase PF00106 (1/1) short chain dehydrogenase
GCF_002551415.1	442.29 +- 0.00	1	1	1	0.01 +- 0.00	1	7 TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF13575 (1/1) Domain of unknown function (DUF4135) PF05147 (1/1) Lanthionine synthetase C-like protein PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_001417695.1	236.60 +- 75.67	5	0	0	0.07 +- 0.06	5	No common domains found
GCF_000716215.1	701.91 +- 588.09	2	0	0	0.04 +- 0.04	2	21 TIGR03567 (1/2) FMN reductase PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain PF14559 (1/2) Tetratricopeptide repeat PF13535 (1/2) ATP-grasp domain PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring) PF13432 (1/2) Tetratricopeptide repeat PF13424 (1/2) Tetratricopeptide repeat PF13378 (1/2) Enolase C-terminal domain-like PF07690 (1/2) Major Facilitator Superfamily PF04203 (1/2) Sortase domain PF03358 (1/2) NADPH-dependent FMN reductase PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01613 (1/2) Flavin reductase like domain PF01547 (1/2) Bacterial extracellular solute-binding protein PF00701 (1/2) Dihydrodipicolinate synthetase family PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00326 (1/2) Prolyl oligopeptidase family PF00294 (1/2) pfkB family carbohydrate kinase
GCF_003074055.1	332.09 +- 206.54	3	0	0	0.02 +- 0.03	3	No common domains found
GCF_001447075.1	1040.00 +- 0.00	1	0	0	0.01 +- 0.00	1	7 PF08386 (1/1) TAP-like protein PF07702 (1/1) UTRA domain PF01380 (1/1) SIS domain PF00561 (1/1) alpha/beta hydrolase fold PF00392 (1/1) Bacterial regulatory proteins, gntR family PF00294 (1/1) pfkB family carbohydrate kinase PF00196 (1/1) Bacterial regulatory proteins, luxR family
GCF_000261345.2	271.28 +- 128.05	3	1	1	0.06 +- 0.04	3	1 PF00005 (2/3) ABC transporter
GCF_001896135.2	260.00 +- 0.00	1	0	0	0.01 +- 0.00	1	2 PF03358 (1/1) NADPH-dependent FMN reductase PF01425 (1/1) Amidase
GCF_001905855.1	101.36 +- 27.64	2	0	0	0.02 +- 0.03	2	6 PF12802 (1/2) MarR family PF07681 (1/2) DoxX PF05977 (1/2) Transmembrane secretion effector PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain PF01261 (1/2) Xylose isomerase-like TIM barrel PF00583 (1/2) Acetyltransferase (GNAT) family
GCF_003112575.1	129.00 +- 0.00	1	1	0	0.04 +- 0.02	1	10 TIGR03301 (1/1) 2-aminoethylphosphonate aminotransferase TIGR03297 (1/1) phosphonopyruvate decarboxylase TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13714 (1/1) Phosphoenolpyruvate phosphomutase PF13454 (1/1) FAD-NAD(P)-binding PF07690 (1/1) Major Facilitator Superfamily PF04116 (1/1) Fatty acid hydroxylase superfamily PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF00266 (1/1) Aminotransferase class-V
GCF_001746465.1	2824.17 +- 144.94	2	2	1	0.01 +- 0.01	2	41 PF00005 (2/2) ABC transporter TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (1/2) diaminopimelate epimerase PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF14518 (1/2) Iron-containing redox enzyme PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal PF13649 (1/2) Methyltransferase domain PF13535 (1/2) ATP-grasp domain PF13458 (1/2) Periplasmic binding protein PF12730 (1/2) ABC-2 family transporter protein PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter PF10014 (1/2) 2OG-Fe dioxygenase PF08241 (1/2) Methyltransferase domain PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (1/2) Aminopeptidase P, N-terminal domain PF05147 (1/2) Lanthionine synthetase C-like protein PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF02153 (1/2) Prephenate dehydrogenase PF01678 (1/2) Diaminopimelate epimerase PF01575 (1/2) MaoC like domain PF01568 (1/2) Molydopterin dinucleotide binding domain PF01425 (1/2) Amidase PF01070 (1/2) FMN-dependent dehydrogenase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (1/2) EamA-like transporter family PF00682 (1/2) HMGL-like PF00557 (1/2) Metallopeptidase family M24 PF00465 (1/2) Iron-containing alcohol dehydrogenase PF00384 (1/2) Molybdopterin oxidoreductase PF00296 (1/2) Luciferase-like monooxygenase PF00248 (1/2) Aldo/keto reductase family PF00202 (1/2) Aminotransferase class-III PF00155 (1/2) Aminotransferase class I and II PF00069 (1/2) Protein kinase domain
GCF_000721185.1	194.57 +- 20.42	2	0	1	0.04 +- 0.02	2	12 PF07690 (2/2) Major Facilitator Superfamily TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13649 (1/2) Methyltransferase domain PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (1/2) alpha/beta hydrolase fold PF04055 (1/2) Radical SAM superfamily PF03781 (1/2) Sulfatase-modifying factor enzyme 1 PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (1/2) Phosphotriesterase family PF01494 (1/2) FAD binding domain PF00884 (1/2) Sulfatase PF00753 (1/2) Metallo-beta-lactamase superfamily
GCF_000518045.1	225.44 +- 109.76	3	0	0	0.01 +- 0.01	3	1 PF00884 (2/3) Sulfatase
GCF_001427245.1	442.00 +- 0.00	1	1	0	0.04 +- 0.05	1	23 TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (1/1) AMP-binding enzyme C-terminal domain PF10862 (1/1) FcoT-like thioesterase domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (1/1) Male sterility protein PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (1/1) Copper chaperone PCu(A)C PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/1) DJ-1/PfpI family PF01497 (1/1) Periplasmic binding protein PF01032 (1/1) FecCD transport family PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase PF00005 (1/1) ABC transporter
GCF_000721535.1	251.73 +- 153.90	4	1	0	0.03 +- 0.05	4	2 PF07690 (2/4) Major Facilitator Superfamily PF01425 (2/4) Amidase
GCF_002551465.1	193.20 +- 145.93	2	1	0	0.04 +- 0.01	2	19 TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13673 (1/2) Acetyltransferase (GNAT) domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12697 (1/2) Alpha/beta hydrolase family PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF04909 (1/2) Amidohydrolase PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01872 (1/2) RibD C-terminal domain PF01144 (1/2) Coenzyme A transferase PF00501 (1/2) AMP-binding enzyme PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00106 (1/2) short chain dehydrogenase PF00005 (1/2) ABC transporter
GCF_000158875.1	409.10 +- 410.25	7	3	1	0.06 +- 0.14	7	No common domains found
GCF_002705665.1	229.41 +- 160.59	2	2	0	0.02 +- 0.03	2	7 PF07883 (1/2) Cupin domain PF01872 (1/2) RibD C-terminal domain PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain PF01609 (1/2) Transposase DDE domain PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00583 (1/2) Acetyltransferase (GNAT) family
GCF_001418655.1	148.14 +- 106.21	2	0	0	0.04 +- 0.04	2	14 TIGR03619 (1/2) probable F420-dependent oxidoreductase, Rv2161c family TIGR01180 (1/2) putative alpha-1,2-mannosidase PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain PF13407 (1/2) Periplasmic binding protein domain PF07971 (1/2) Glycosyl hydrolase family 92 PF07969 (1/2) Amidohydrolase family PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF00672 (1/2) HAMP domain PF00553 (1/2) Cellulose binding domain PF00512 (1/2) His Kinase A (phospho-acceptor) domain PF00296 (1/2) Luciferase-like monooxygenase PF00005 (1/2) ABC transporter
GCF_900103585.1	435.05 +- 416.85	5	2	0	0.04 +- 0.06	5	No common domains found
GCF_002317005.1	540.57 +- 0.00	1	1	0	0.07 +- 0.06	1	28 TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (1/1) AMP-binding enzyme C-terminal domain PF10862 (1/1) FcoT-like thioesterase domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08281 (1/1) Sigma-70, region 4 PF07993 (1/1) Male sterility protein PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (1/1) Sigma-70 region 2 PF04314 (1/1) Copper chaperone PCu(A)C PF03929 (1/1) PepSY-associated TM region PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/1) DJ-1/PfpI family PF01794 (1/1) Ferric reductase like transmembrane component PF01497 (1/1) Periplasmic binding protein PF01032 (1/1) FecCD transport family PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase PF00005 (1/1) ABC transporter
GCF_002242805.1	256.59 +- 82.97	4	2	0	0.04 +- 0.16	4	No common domains found
GCF_000377525.1	5460.00 +- 0.00	1	1	1	0.01 +- 0.00	1	9 TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF13560 (1/1) Helix-turn-helix domain PF04149 (1/1) Domain of unknown function (DUF397) PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00881 (1/1) Nitroreductase family PF00196 (1/1) Bacterial regulatory proteins, luxR family
GCF_001886595.1	187.39 +- 133.37	4	2	2	0.02 +- 0.01	4	No common domains found
GCF_900091315.1	737.77 +- 250.44	3	3	3	0.02 +- 0.03	3	1 PF04055 (2/3) Radical SAM superfamily
GCF_002803195.1	453.12 +- 406.37	5	1	1	0.03 +- 0.05	5	No common domains found
GCF_000717915.1	327.88 +- 155.87	2	1	1	0.02 +- 0.02	2	16 TIGR00928 (1/2) adenylosuccinate lyase PF13673 (1/2) Acetyltransferase (GNAT) domain PF13454 (1/2) FAD-NAD(P)-binding PF10397 (1/2) Adenylosuccinate lyase C-terminus PF08386 (1/2) TAP-like protein PF07969 (1/2) Amidohydrolase family PF07690 (1/2) Major Facilitator Superfamily PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF03704 (1/2) Bacterial transcriptional activator domain PF01425 (1/2) Amidase PF00931 (1/2) NB-ARC domain PF00561 (1/2) alpha/beta hydrolase fold PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00206 (1/2) Lyase PF00120 (1/2) Glutamine synthetase, catalytic domain
GCF_000721525.1	309.60 +- 0.00	1	0	0	0.01 +- 0.00	1	4 PF06628 (1/1) Catalase-related immune-responsive PF01475 (1/1) Ferric uptake regulator family PF00248 (1/1) Aldo/keto reductase family PF00199 (1/1) Catalase
GCF_000720505.1	57.33 +- 0.00	1	0	0	0.07 +- 0.03	1	6 PF18603 (1/1) L-amino acid ligase C-terminal domain 2 PF13649 (1/1) Methyltransferase domain PF13535 (1/1) ATP-grasp domain PF07690 (1/1) Major Facilitator Superfamily PF01794 (1/1) Ferric reductase like transmembrane component PF00291 (1/1) Pyridoxal-phosphate dependent enzyme
GCF_000383655.1	258.00 +- 0.00	1	0	1	0.01 +- 0.00	1	9 TIGR04276 (1/1) FxsC C-terminal domain TIGR04269 (1/1) radical SAM/SPASM domain protein, FxsB family TIGR04267 (1/1) HEXXH motif domain PF13676 (1/1) TIR domain PF13424 (1/1) Tetratricopeptide repeat PF13374 (1/1) Tetratricopeptide repeat PF04055 (1/1) Radical SAM superfamily PF01656 (1/1) CobQ/CobB/MinD/ParA nucleotide binding domain PF00931 (1/1) NB-ARC domain
GCF_900221035.1	448.85 +- 500.64	7	2	1	0.02 +- 0.04	7	1 PF07690 (5/7) Major Facilitator Superfamily
GCF_000162775.1	388.54 +- 336.20	4	1	0	0.02 +- 0.03	4	No common domains found
GCF_002317035.1	114.67 +- 57.33	2	1	0	0.06 +- 0.03	2	25 TIGR01746 (1/2) thioester reductase domain TIGR01733 (1/2) amino acid adenylation domain PF18130 (1/2) ATP-grasp N-terminal domain PF17908 (1/2) APAF-1 helical domain PF13640 (1/2) 2OG-Fe(II) oxygenase superfamily PF13586 (1/2) Transposase DDE domain PF13535 (1/2) ATP-grasp domain PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096) PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12770 (1/2) CHAT domain PF07993 (1/2) Male sterility protein PF07510 (1/2) Protein of unknown function (DUF1524) PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase PF04555 (1/2) Restriction endonuclease XhoI PF03235 (1/2) Protein of unknown function DUF262 PF01937 (1/2) Protein of unknown function DUF89 PF01609 (1/2) Transposase DDE domain PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain PF00931 (1/2) NB-ARC domain PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00400 (1/2) WD domain, G-beta repeat PF00106 (1/2) short chain dehydrogenase
GCF_001687325.1	435.83 +- 549.81	3	2	2	0.04 +- 0.09	3	No common domains found
GCF_001905845.1	71.89 +- 0.00	1	0	0	0.08 +- 0.13	1	11 PF13672 (1/1) Protein phosphatase 2C PF13519 (1/1) von Willebrand factor type A domain PF13353 (1/1) 4Fe-4S single cluster domain PF13309 (1/1) HTH domain PF12770 (1/1) CHAT domain PF08808 (1/1) RES domain PF08348 (1/1) YheO-like PAS domain PF07724 (1/1) AAA domain (Cdc48 subfamily) PF00291 (1/1) Pyridoxal-phosphate dependent enzyme PF00069 (1/1) Protein kinase domain PF00012 (1/1) Hsp70 protein
GCF_000963515.1	515.55 +- 675.40	7	3	1	0.02 +- 0.03	7	No common domains found
GCF_002276245.1	299.00 +- 0.00	1	0	0	0.03 +- 0.14	1	14 TIGR01554 (1/1) phage major capsid protein, HK97 family TIGR01543 (1/1) phage prohead protease, HK97 family TIGR01537 (1/1) phage portal protein, HK97 family TIGR00621 (1/1) single-stranded DNA-binding protein PF14594 (1/1) Siphovirus ReqiPepy6 Gp37-like protein PF12708 (1/1) Pectate lyase superfamily protein PF12307 (1/1) Protein of unknown function (DUF3631) PF05709 (1/1) Phage tail protein PF05065 (1/1) Phage capsid family PF04860 (1/1) Phage portal protein PF04586 (1/1) Caudovirus prohead serine protease PF01844 (1/1) HNH endonuclease PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase PF00436 (1/1) Single-strand binding protein family
GCF_002946835.1	156.24 +- 122.33	2	0	0	0.05 +- 0.07	2	11 TIGR00561 (1/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF12769 (1/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch PF05222 (1/2) Alanine dehydrogenase/PNT, N-terminal domain PF02233 (1/2) NAD(P) transhydrogenase beta subunit PF02225 (1/2) PA domain PF01978 (1/2) Sugar-specific transcriptional regulator TrmB PF01262 (1/2) Alanine dehydrogenase/PNT, C-terminal domain PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00082 (1/2) Subtilase family
GCF_000382745.1	667.87 +- 141.02	2	2	0	0.01 +- 0.01	2	24 TIGR01891 (1/2) amidohydrolase TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01821 (1/2) 5-aminolevulinic acid synthase TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF16884 (1/2) N-terminal domain of oxidoreductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08443 (1/2) RimK-like ATP-grasp domain PF07690 (1/2) Major Facilitator Superfamily PF03466 (1/2) LysR substrate binding domain PF02780 (1/2) Transketolase, C-terminal domain PF02779 (1/2) Transketolase, pyrimidine binding domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (1/2) Peptidase family M20/M25/M40 PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00501 (1/2) AMP-binding enzyme PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00155 (1/2) Aminotransferase class I and II PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00107 (1/2) Zinc-binding dehydrogenase
GCF_003933965.1	326.29 +- 189.71	2	0	0	0.03 +- 0.04	2	17 TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence PF14329 (1/2) Domain of unknown function (DUF4386) PF09339 (1/2) IclR helix-turn-helix domain PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF02866 (1/2) lactate/malate dehydrogenase, alpha/beta C-terminal domain PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PF02452 (1/2) PemK-like, MazF-like toxin of type II toxin-antitoxin system PF01614 (1/2) Bacterial transcriptional regulator PF01476 (1/2) LysM domain PF01425 (1/2) Amidase PF00795 (1/2) Carbon-nitrogen hydrolase PF00561 (1/2) alpha/beta hydrolase fold PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain PF00171 (1/2) Aldehyde dehydrogenase family PF00144 (1/2) Beta-lactamase PF00056 (1/2) lactate/malate dehydrogenase, NAD binding domain
GCF_000720875.1	547.05 +- 848.21	5	0	0	0.04 +- 0.09	5	No common domains found
GCF_001700505.1	124.55 +- 0.00	1	0	1	0.03 +- 0.04	1	7 PF13581 (1/1) Histidine kinase-like ATPase domain PF13191 (1/1) AAA ATPase domain PF09346 (1/1) SMI1 / KNR4 family (SUKH-1) PF05147 (1/1) Lanthionine synthetase C-like protein PF00561 (1/1) alpha/beta hydrolase fold PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00005 (1/1) ABC transporter
GCF_000497445.1	175.91 +- 0.00	1	0	0	0.02 +- 0.02	1	4 PF13377 (1/1) Periplasmic binding protein-like domain PF08007 (1/1) Cupin superfamily protein PF02435 (1/1) Levansucrase/Invertase PF00356 (1/1) Bacterial regulatory proteins, lacI family
GCF_002891865.1	274.03 +- 287.20	5	1	1	0.04 +- 0.04	5	No common domains found
GCF_000259895.1	130.00 +- 0.00	1	0	0	0.04 +- 0.01	1	6 TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13460 (1/1) NAD(P)H-binding PF07690 (1/1) Major Facilitator Superfamily PF01814 (1/1) Hemerythrin HHE cation binding domain PF01494 (1/1) FAD binding domain PF00561 (1/1) alpha/beta hydrolase fold
GCF_002217715.1	421.38 +- 450.74	4	1	1	0.03 +- 0.04	4	1 PF00005 (2/4) ABC transporter
GCF_000719365.1	207.58 +- 38.70	3	1	0	0.03 +- 0.05	3	No common domains found
GCF_001189035.1	602.00 +- 0.00	1	0	0	0.01 +- 0.01	1	7 PF17900 (1/1) Peptidase M1 N-terminal domain PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain PF02423 (1/1) Ornithine cyclodeaminase/mu-crystallin family PF01965 (1/1) DJ-1/PfpI family PF01433 (1/1) Peptidase family M1 domain PF00440 (1/1) Bacterial regulatory proteins, tetR family PF00082 (1/1) Subtilase family
GCF_900110735.1	129.13 +- 42.47	2	1	0	0.05 +- 0.02	2	19 TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family TIGR00345 (1/2) transport-energizing ATPase, TRC40/GET3/ArsA family PF13722 (1/2) 5TM C-terminal transporter carbon starvation CstA PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08443 (1/2) RimK-like ATP-grasp domain PF02812 (1/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF02554 (1/2) Carbon starvation protein CstA PF02374 (1/2) Anion-transporting ATPase PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region PF00696 (1/2) Amino acid kinase family PF00682 (1/2) HMGL-like PF00501 (1/2) AMP-binding enzyme PF00326 (1/2) Prolyl oligopeptidase family PF00208 (1/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PF00155 (1/2) Aminotransferase class I and II PF00117 (1/2) Glutamine amidotransferase class-I
GCF_000376565.1	629.20 +- 0.00	1	0	0	0.02 +- 0.01	1	10 TIGR02276 (1/1) 40-residue YVTN family beta-propeller repeat PF13759 (1/1) Putative 2OG-Fe(II) oxygenase PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region PF07690 (1/1) Major Facilitator Superfamily PF06224 (1/1) Winged helix DNA-binding domain PF02239 (1/1) Cytochrome D1 heme domain PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_000718615.1	340.92 +- 81.57	2	1	0	0.05 +- 0.16	2	35 TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB TIGR03930 (1/2) WXG100 family type VII secretion target TIGR03920 (1/2) type VII secretion integral membrane protein EccD TIGR03919 (1/2) type VII secretion protein EccB TIGR01733 (1/2) amino acid adenylation domain TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720 TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein PF15644 (1/2) Papain fold toxin 1, glutamine deamidase PF13796 (1/2) Putative sensor PF13578 (1/2) Methyltransferase domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD PF08659 (1/2) KR domain PF07730 (1/2) Histidine kinase PF07179 (1/2) SseB protein N-terminal domain PF06259 (1/2) Alpha/beta hydrolase PF06013 (1/2) Proteins of 100 residues with WXG PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B PF03621 (1/2) MbtH-like protein PF02687 (1/2) FtsX-like permease family PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF02575 (1/2) YbaB/EbfC DNA-binding family PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF01757 (1/2) Acyltransferase family PF01061 (1/2) ABC-2 type transporter PF00975 (1/2) Thioesterase domain PF00668 (1/2) Condensation domain PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00291 (1/2) Pyridoxal-phosphate dependent enzyme PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00072 (1/2) Response regulator receiver domain PF00005 (1/2) ABC transporter
GCF_000743295.1	930.68 +- 1002.30	3	1	1	0.02 +- 0.01	3	1 PF00005 (2/3) ABC transporter
GCF_000718625.1	355.33 +- 150.61	3	1	0	0.02 +- 0.05	3	4 PF07291 (2/3) Methylamine utilisation protein MauE PF00717 (2/3) Peptidase S24-like PF00578 (2/3) AhpC/TSA family PF00005 (2/3) ABC transporter
GCF_003182455.1	187.39 +- 133.37	4	2	2	0.02 +- 0.01	4	No common domains found
GCF_001905525.1	223.60 +- 34.40	2	1	0	0.04 +- 0.07	2	14 TIGR03920 (1/2) type VII secretion integral membrane protein EccD TIGR03919 (1/2) type VII secretion protein EccB PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF12680 (1/2) SnoaL-like domain PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD PF07179 (1/2) SseB protein N-terminal domain PF07045 (1/2) Domain of unknown function (DUF1330) PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif PF02575 (1/2) YbaB/EbfC DNA-binding family PF01738 (1/2) Dienelactone hydrolase family PF00664 (1/2) ABC transporter transmembrane region PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00005 (1/2) ABC transporter
GCF_002005225.1	502.43 +- 0.00	1	1	0	0.03 +- 0.03	1	18 PF16197 (1/1) Ketoacyl-synthetase C-terminal extension PF14765 (1/1) Polyketide synthase dehydratase PF13191 (1/1) AAA ATPase domain PF08659 (1/1) KR domain PF04820 (1/1) Tryptophan halogenase PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03704 (1/1) Bacterial transcriptional activator domain PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain PF01613 (1/1) Flavin reductase like domain PF00999 (1/1) Sodium/hydrogen exchanger family PF00975 (1/1) Thioesterase domain PF00931 (1/1) NB-ARC domain PF00698 (1/1) Acyl transferase domain PF00550 (1/1) Phosphopantetheine attachment site PF00486 (1/1) Transcriptional regulatory protein, C terminal PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain PF00107 (1/1) Zinc-binding dehydrogenase
GCF_004010275.1	1560.00 +- 0.00	1	1	1	0.01 +- 0.00	1	8 PF13471 (1/1) Transglutaminase-like superfamily PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (1/1) Asparagine synthase PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00072 (1/1) Response regulator receiver domain PF00005 (1/1) ABC transporter
GCF_900090085.1	1238.40 +- 0.00	1	1	1	0.01 +- 0.01	1	8 TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF13575 (1/1) Domain of unknown function (DUF4135) PF12679 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_900104865.1	260.45 +- 175.21	6	3	1	0.04 +- 0.14	6	1 PF07690 (4/6) Major Facilitator Superfamily
GCF_900177255.1	672.38 +- 761.59	3	1	2	0.03 +- 0.08	3	No common domains found
GCF_003933295.1	199.99 +- 154.70	4	1	0	0.04 +- 0.07	4	1 PF07690 (3/4) Major Facilitator Superfamily
GCF_001280125.1	282.30 +- 219.37	2	0	0	0.04 +- 0.08	2	13 PF18556 (1/2) Bacterial Tetracyclin repressor, C-terminal domain PF17754 (1/2) MftR C-terminal domain PF13460 (1/2) NAD(P)H-binding PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF04324 (1/2) BFD-like [2Fe-2S] binding domain PF04075 (1/2) F420H(2)-dependent quinone reductase PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain PF01418 (1/2) Helix-turn-helix domain, rpiR family PF01380 (1/2) SIS domain PF01266 (1/2) FAD dependent oxidoreductase PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain PF00293 (1/2) NUDIX domain
GCF_002551435.1	197.77 +- 128.18	3	1	0	0.07 +- 0.13	3	1 PF00005 (2/3) ABC transporter
GCF_000720145.1	387.00 +- 0.00	1	0	0	0.01 +- 0.00	1	5 PF17874 (1/1) MalT-like TPR region PF12770 (1/1) CHAT domain PF04030 (1/1) D-arabinono-1,4-lactone oxidase PF01565 (1/1) FAD binding domain PF00248 (1/1) Aldo/keto reductase family
GCF_003330845.1	126.33 +- 9.33	2	0	0	0.03 +- 0.01	2	15 PF16349 (1/2) Domain of unknown function (DUF4978) PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF14100 (1/2) Methane oxygenase PmoA PF13377 (1/2) Periplasmic binding protein-like domain PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin PF12697 (1/2) Alpha/beta hydrolase family PF11706 (1/2) CGNR zinc finger PF09339 (1/2) IclR helix-turn-helix domain PF07883 (1/2) Cupin domain PF02894 (1/2) Oxidoreductase family, C-terminal alpha/beta domain PF02525 (1/2) Flavodoxin-like fold PF01614 (1/2) Bacterial transcriptional regulator PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00356 (1/2) Bacterial regulatory proteins, lacI family
GCF_000719415.1	1225.38 +- 1932.98	5	2	2	0.03 +- 0.05	5	No common domains found
GCF_002551305.1	73.71 +- 0.00	1	1	0	0.03 +- 0.02	1	3 TIGR03083 (1/1) uncharacterized Actinobacterial protein TIGR03083 PF11716 (1/1) Mycothiol maleylpyruvate isomerase N-terminal domain PF02627 (1/1) Carboxymuconolactone decarboxylase family
GCF_900091955.1	199.03 +- 84.51	6	1	1	0.04 +- 0.05	6	No common domains found
GCF_001895105.1	260.00 +- 0.00	1	0	0	0.01 +- 0.00	1	2 PF09995 (1/1) Uncharacterized protein conserved in bacteria (DUF2236) PF00246 (1/1) Zinc carboxypeptidase
GCF_000156435.1	110.12 +- 0.00	1	0	0	0.05 +- 0.09	1	8 PF12450 (1/1) von Willebrand factor PF12034 (1/1) Domain of unknown function (DUF3520) PF10502 (1/1) Signal peptidase, peptidase S26 PF07291 (1/1) Methylamine utilisation protein MauE PF00717 (1/1) Peptidase S24-like PF00501 (1/1) AMP-binding enzyme PF00092 (1/1) von Willebrand factor type A domain PF00005 (1/1) ABC transporter
GCF_003428925.1	177.38 +- 145.12	2	0	0	0.03 +- 0.02	2	10 PF00561 (2/2) alpha/beta hydrolase fold PF12697 (1/2) Alpha/beta hydrolase family PF11723 (1/2) Homotrimeric ring hydroxylase PF08386 (1/2) TAP-like protein PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase PF01546 (1/2) Peptidase family M20/M25/M40 PF01471 (1/2) Putative peptidoglycan binding domain PF00355 (1/2) Rieske [2Fe-2S] domain PF00175 (1/2) Oxidoreductase NAD-binding domain PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
GCF_001751245.1	103.20 +- 0.00	1	1	0	0.02 +- 0.00	1	2 PF13302 (1/1) Acetyltransferase (GNAT) domain PF00156 (1/1) Phosphoribosyl transferase domain
GCF_000349325.1	1012.15 +- 19.85	2	1	1	0.01 +- 0.00	2	13 TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain TIGR03296 (1/2) M6 family metalloprotease domain PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain PF13186 (1/2) Iron-sulfur cluster-binding domain PF09339 (1/2) IclR helix-turn-helix domain PF08241 (1/2) Methyltransferase domain PF07690 (1/2) Major Facilitator Superfamily PF04055 (1/2) Radical SAM superfamily PF01980 (1/2) tRNA-methyltransferase O PF01614 (1/2) Bacterial transcriptional regulator PF01494 (1/2) FAD binding domain PF01471 (1/2) Putative peptidoglycan binding domain PF00440 (1/2) Bacterial regulatory proteins, tetR family
GCF_900107965.1	274.12 +- 112.88	2	2	2	0.02 +- 0.03	2	17 TIGR03558 (1/2) luciferase family oxidoreductase, group 1 TIGR02822 (1/2) zinc-binding alcohol dehydrogenase family protein PF14518 (1/2) Iron-containing redox enzyme PF13191 (1/2) AAA ATPase domain PF13185 (1/2) GAF domain PF08240 (1/2) Alcohol dehydrogenase GroES-like domain PF07690 (1/2) Major Facilitator Superfamily PF05630 (1/2) Necrosis inducing protein (NPP1) PF05147 (1/2) Lanthionine synthetase C-like protein PF04055 (1/2) Radical SAM superfamily PF03704 (1/2) Bacterial transcriptional activator domain PF00931 (1/2) NB-ARC domain PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00296 (1/2) Luciferase-like monooxygenase PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain PF00082 (1/2) Subtilase family PF00069 (1/2) Protein kinase domain
GCF_900105915.1	118.86 +- 0.00	1	0	0	0.03 +- 0.03	1	6 PF12833 (1/1) Helix-turn-helix domain PF10502 (1/1) Signal peptidase, peptidase S26 PF07291 (1/1) Methylamine utilisation protein MauE PF00717 (1/1) Peptidase S24-like PF00578 (1/1) AhpC/TSA family PF00005 (1/1) ABC transporter
GCF_900142595.1	1227.17 +- 1178.68	3	2	0	0.01 +- 0.01	3	2 PF07690 (2/3) Major Facilitator Superfamily PF00196 (2/3) Bacterial regulatory proteins, luxR family
GCF_003984785.1	403.88 +- 0.00	1	1	0	0.04 +- 0.03	1	25 TIGR01733 (1/1) amino acid adenylation domain PF16653 (1/1) Saccharopine dehydrogenase C-terminal domain PF14518 (1/1) Iron-containing redox enzyme PF13714 (1/1) Phosphoenolpyruvate phosphomutase PF13535 (1/1) ATP-grasp domain PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring) PF13302 (1/1) Acetyltransferase (GNAT) domain PF13193 (1/1) AMP-binding enzyme C-terminal domain PF09334 (1/1) tRNA synthetases class I (M) PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF07883 (1/1) Cupin domain PF07690 (1/1) Major Facilitator Superfamily PF05222 (1/1) Alanine dehydrogenase/PNT, N-terminal domain PF03435 (1/1) Saccharopine dehydrogenase NADP binding domain PF03417 (1/1) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily PF01266 (1/1) FAD dependent oxidoreductase PF00975 (1/1) Thioesterase domain PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain PF00067 (1/1) Cytochrome P450
GCF_000377545.1	241.21 +- 170.50	3	1	1	0.07 +- 0.12	3	No common domains found
GCF_004195885.1	22.94 +- 0.00	1	0	0	0.09 +- 0.06	1	4 PF17074 (1/1) Darcynin, domain of unknown function PF08021 (1/1) Siderophore-interacting FAD-binding domain PF04954 (1/1) Siderophore-interacting protein PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase
GCF_000717895.1	169.72 +- 120.26	3	1	1	0.08 +- 0.14	3	No common domains found
GCF_001279685.1	618.44 +- 542.56	2	0	1	0.03 +- 0.05	2	29 TIGR02493 (1/2) pyruvate formate-lyase 1-activating enzyme TIGR01828 (1/2) pyruvate, phosphate dikinase TIGR01426 (1/2) glycosyltransferase, MGT family TIGR01255 (1/2) formate acetyltransferase PF17914 (1/2) HopA1 effector protein family PF14325 (1/2) Domain of unknown function (DUF4383) PF13692 (1/2) Glycosyl transferases group 1 PF13601 (1/2) Winged helix DNA-binding domain PF13411 (1/2) MerR HTH family regulatory protein PF12698 (1/2) ABC-2 family transporter protein PF05719 (1/2) Golgi phosphoprotein 3 (GPP34) PF05193 (1/2) Peptidase M16 inactive domain PF04055 (1/2) Radical SAM superfamily PF02901 (1/2) Pyruvate formate lyase-like PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain PF02607 (1/2) B12 binding domain PF02441 (1/2) Flavoprotein PF01636 (1/2) Phosphotransferase enzyme family PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01228 (1/2) Glycine radical PF00891 (1/2) O-methyltransferase domain PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00582 (1/2) Universal stress protein family PF00391 (1/2) PEP-utilising enzyme, mobile domain PF00296 (1/2) Luciferase-like monooxygenase PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase PF00106 (1/2) short chain dehydrogenase PF00005 (1/2) ABC transporter
GCF_003144095.1	119.08 +- 0.00	1	0	0	0.02 +- 0.02	1	3 PF13560 (1/1) Helix-turn-helix domain PF00891 (1/1) O-methyltransferase domain PF00239 (1/1) Resolvase, N terminal domain
GCF_000725885.1	260.00 +- 0.00	1	0	0	0.01 +- 0.00	1	1 PF04655 (1/1) Aminoglycoside/hydroxyurea antibiotic resistance kinase
GCF_900112845.1	1316.55 +- 1130.39	4	4	2	0.01 +- 0.01	4	3 PF13575 (2/4) Domain of unknown function (DUF4135) PF00664 (2/4) ABC transporter transmembrane region PF00005 (2/4) ABC transporter
GCF_002156075.1	100.29 +- 48.29	2	0	0	0.03 +- 0.03	2	9 PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain PF16757 (1/2) Alpha-L-fucosidase C-terminal domain PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF13460 (1/2) NAD(P)H-binding PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain PF01120 (1/2) Alpha-L-fucosidase PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00561 (1/2) alpha/beta hydrolase fold
GCF_000404005.1	252.97 +- 0.00	1	1	1	0.09 +- 0.25	1	11 TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF14867 (1/1) Lantibiotic alpha PF13601 (1/1) Winged helix DNA-binding domain PF13575 (1/1) Domain of unknown function (DUF4135) PF12730 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF04820 (1/1) Tryptophan halogenase PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_003041235.1	33.33 +- 0.00	1	0	0	0.06 +- 0.09	1	6 PF17996 (1/1) Carbohydrate esterase 2 N-terminal PF17829 (1/1) Gylcosyl hydrolase family 115 C-terminal domain PF15979 (1/1) Glycosyl hydrolase family 115 PF13472 (1/1) GDSL-like Lipase/Acylhydrolase family PF13191 (1/1) AAA ATPase domain PF00067 (1/1) Cytochrome P450
GCF_002217755.1	1093.43 +- 1235.07	3	1	0	0.01 +- 0.02	3	No common domains found
GCF_000816025.1	159.69 +- 145.38	8	3	0	0.05 +- 0.08	8	No common domains found
GCF_003949535.1	412.80 +- 0.00	1	1	0	0.01 +- 0.00	1	7 PF17914 (1/1) HopA1 effector protein family PF13649 (1/1) Methyltransferase domain PF13546 (1/1) DDE superfamily endonuclease PF05193 (1/1) Peptidase M16 inactive domain PF01636 (1/1) Phosphotransferase enzyme family PF00675 (1/1) Insulinase (Peptidase family M16) PF00005 (1/1) ABC transporter
GCF_900116145.1	78.93 +- 17.82	2	1	0	0.06 +- 0.06	2	20 TIGR03557 (1/2) F420-dependent oxidoreductase, G6PDH family TIGR01733 (1/2) amino acid adenylation domain TIGR01136 (1/2) cysteine synthase PF14027 (1/2) Questin oxidase-like PF12833 (1/2) Helix-turn-helix domain PF11814 (1/2) Peptidase_C39 like family PF02311 (1/2) AraC-like ligand binding domain PF01497 (1/2) Periplasmic binding protein PF01032 (1/2) FecCD transport family PF00975 (1/2) Thioesterase domain PF00892 (1/2) EamA-like transporter family PF00550 (1/2) Phosphopantetheine attachment site PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family PF00501 (1/2) AMP-binding enzyme PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00296 (1/2) Luciferase-like monooxygenase PF00291 (1/2) Pyridoxal-phosphate dependent enzyme PF00132 (1/2) Bacterial transferase hexapeptide (six repeats) PF00082 (1/2) Subtilase family PF00005 (1/2) ABC transporter
GCF_000720405.1	321.58 +- 61.58	2	1	1	0.02 +- 0.01	2	17 TIGR00229 (1/2) PAS domain S-box protein PF08448 (1/2) PAS fold PF08220 (1/2) DeoR-like helix-turn-helix domain PF07690 (1/2) Major Facilitator Superfamily PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF04055 (1/2) Radical SAM superfamily PF03466 (1/2) LysR substrate binding domain PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain PF02310 (1/2) B12 binding domain PF01590 (1/2) GAF domain PF01494 (1/2) FAD binding domain PF00733 (1/2) Asparagine synthase PF00501 (1/2) AMP-binding enzyme PF00455 (1/2) DeoR C terminal sensor domain PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00069 (1/2) Protein kinase domain
GCF_000720535.1	109.97 +- 12.47	2	0	1	0.06 +- 0.04	2	12 PF07690 (2/2) Major Facilitator Superfamily TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13649 (1/2) Methyltransferase domain PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (1/2) alpha/beta hydrolase fold PF04055 (1/2) Radical SAM superfamily PF03781 (1/2) Sulfatase-modifying factor enzyme 1 PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (1/2) Phosphotriesterase family PF01494 (1/2) FAD binding domain PF00884 (1/2) Sulfatase PF00753 (1/2) Metallo-beta-lactamase superfamily
GCF_004127445.1	422.83 +- 255.32	4	2	2	0.03 +- 0.11	4	4 PF07690 (3/4) Major Facilitator Superfamily PF04055 (2/4) Radical SAM superfamily PF02310 (2/4) B12 binding domain PF00326 (2/4) Prolyl oligopeptidase family
GCF_003121295.1	235.10 +- 135.05	3	0	1	0.03 +- 0.09	3	No common domains found
GCF_000938975.1	440.14 +- 205.13	5	1	0	0.04 +- 0.09	5	No common domains found
GCF_000725745.1	348.73 +- 213.99	3	0	0	0.05 +- 0.12	3	No common domains found
GCF_000242715.1	346.16 +- 55.91	2	1	0	0.06 +- 0.22	2	26 TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01746 (1/2) thioester reductase domain TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF13560 (1/2) Helix-turn-helix domain PF13535 (1/2) ATP-grasp domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF10901 (1/2) Protein of unknown function (DUF2690) PF08443 (1/2) RimK-like ATP-grasp domain PF07993 (1/2) Male sterility protein PF07690 (1/2) Major Facilitator Superfamily PF02779 (1/2) Transketolase, pyrimidine binding domain PF01546 (1/2) Peptidase family M20/M25/M40 PF01471 (1/2) Putative peptidoglycan binding domain PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (1/2) Amino acid kinase family PF00664 (1/2) ABC transporter transmembrane region PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00300 (1/2) Histidine phosphatase superfamily (branch 1) PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00005 (1/2) ABC transporter
GCF_000718305.1	211.04 +- 104.96	6	0	2	0.06 +- 0.16	6	No common domains found
GCF_003248355.1	732.61 +- 344.29	5	4	3	0.02 +- 0.02	5	1 PF07690 (4/5) Major Facilitator Superfamily
GCF_000718635.1	1058.57 +- 583.30	4	4	2	0.01 +- 0.00	4	2 PF00550 (2/4) Phosphopantetheine attachment site PF00005 (2/4) ABC transporter
GCF_000253235.1	269.79 +- 233.27	6	2	2	0.03 +- 0.11	6	No common domains found
GCF_000154885.1	288.99 +- 200.93	2	1	0	0.05 +- 0.07	2	32 PF07690 (2/2) Major Facilitator Superfamily TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating) TIGR00566 (1/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase TIGR00553 (1/2) aminodeoxychorismate synthase, component I PF13622 (1/2) Thioesterase-like superfamily PF13621 (1/2) Cupin-like domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12146 (1/2) Serine aminopeptidase, S33 PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF08031 (1/2) Berberine and berberine like PF07836 (1/2) DmpG-like communication domain PF04715 (1/2) Anthranilate synthase component I, N terminal region PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF01565 (1/2) FAD binding domain PF01494 (1/2) FAD binding domain PF01474 (1/2) Class-II DAHP synthetase family PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF01063 (1/2) Amino-transferase class IV PF00682 (1/2) HMGL-like PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00487 (1/2) Fatty acid desaturase PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00425 (1/2) chorismate binding enzyme PF00301 (1/2) Rubredoxin PF00171 (1/2) Aldehyde dehydrogenase family PF00155 (1/2) Aminotransferase class I and II PF00117 (1/2) Glutamine amidotransferase class-I PF00067 (1/2) Cytochrome P450
GCF_003048205.2	218.08 +- 48.86	3	2	2	0.04 +- 0.13	3	1 PF07690 (2/3) Major Facilitator Superfamily
GCF_000373525.1	645.36 +- 394.64	2	1	1	0.03 +- 0.03	2	19 TIGR03396 (1/2) phospholipase C, phosphocholine-specific TIGR01258 (1/2) phosphoglycerate mutase 1 family TIGR01060 (1/2) phosphopyruvate hydratase PF11575 (1/2) FhuF 2Fe-2S C-terminal domain PF07690 (1/2) Major Facilitator Superfamily PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF05506 (1/2) Domain of unknown function (DUF756) PF04185 (1/2) Phosphoesterase family PF04055 (1/2) Radical SAM superfamily PF03965 (1/2) Penicillinase repressor PF03952 (1/2) Enolase, N-terminal domain PF03453 (1/2) MoeA N-terminal region (domain I and II) PF02441 (1/2) Flavoprotein PF01712 (1/2) Deoxynucleoside kinase PF01435 (1/2) Peptidase family M48 PF00994 (1/2) Probable molybdopterin binding domain PF00300 (1/2) Histidine phosphatase superfamily (branch 1) PF00293 (1/2) NUDIX domain PF00113 (1/2) Enolase, C-terminal TIM barrel domain
GCF_003687505.1	341.57 +- 113.49	3	1	0	0.02 +- 0.05	3	No common domains found
GCF_002920615.1	559.00 +- 481.00	2	0	0	0.02 +- 0.03	2	12 PF07690 (2/2) Major Facilitator Superfamily PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF17676 (1/2) LD-carboxypeptidase C-terminal domain PF13649 (1/2) Methyltransferase domain PF13535 (1/2) ATP-grasp domain PF13460 (1/2) NAD(P)H-binding PF13393 (1/2) Histidyl-tRNA synthetase PF07859 (1/2) alpha/beta hydrolase fold PF02016 (1/2) LD-carboxypeptidase N-terminal domain PF00296 (1/2) Luciferase-like monooxygenase PF00152 (1/2) tRNA synthetases class II (D, K and N) PF00067 (1/2) Cytochrome P450
GCF_000717285.1	71.86 +- 41.63	3	2	1	0.08 +- 0.08	3	No common domains found
GCF_004195995.1	44.48 +- 0.00	1	0	0	0.04 +- 0.03	1	5 PF13515 (1/1) Fusaric acid resistance protein-like PF08386 (1/1) TAP-like protein PF01471 (1/1) Putative peptidoglycan binding domain PF00931 (1/1) NB-ARC domain PF00561 (1/1) alpha/beta hydrolase fold
GCF_000009765.2	191.74 +- 10.48	2	1	0	0.07 +- 0.10	2	17 PF07690 (2/2) Major Facilitator Superfamily TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain PF14224 (1/2) Domain of unknown function (DUF4331) PF13450 (1/2) NAD(P)-binding Rossmann-like domain PF08240 (1/2) Alcohol dehydrogenase GroES-like domain PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF02882 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF00925 (1/2) GTP cyclohydrolase II PF00763 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain PF00743 (1/2) Flavin-binding monooxygenase-like PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00348 (1/2) Polyprenyl synthetase PF00107 (1/2) Zinc-binding dehydrogenase PF00106 (1/2) short chain dehydrogenase PF00082 (1/2) Subtilase family
GCF_000964305.1	117.96 +- 12.04	2	0	0	0.06 +- 0.09	2	21 TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family TIGR01891 (1/2) amidohydrolase PF13738 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF13302 (1/2) Acetyltransferase (GNAT) domain PF13091 (1/2) PLD-like domain PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236) PF09084 (1/2) NMT1/THI5 like PF06267 (1/2) Family of unknown function (DUF1028) PF05719 (1/2) Golgi phosphoprotein 3 (GPP34) PF03466 (1/2) LysR substrate binding domain PF02386 (1/2) Cation transport protein PF02254 (1/2) TrkA-N domain PF02080 (1/2) TrkA-C domain PF01546 (1/2) Peptidase family M20/M25/M40 PF01042 (1/2) Endoribonuclease L-PSP PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00296 (1/2) Luciferase-like monooxygenase PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00083 (1/2) Sugar (and other) transporter PF00005 (1/2) ABC transporter
GCF_000718675.1	47.24 +- 3.02	2	1	1	0.09 +- 0.08	2	12 PF14158 (1/2) YndJ-like protein PF13581 (1/2) Histidine kinase-like ATPase domain PF13492 (1/2) GAF domain PF13471 (1/2) Transglutaminase-like superfamily PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF09348 (1/2) Domain of unknown function (DUF1990) PF08447 (1/2) PAS fold PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase PF00733 (1/2) Asparagine synthase PF00149 (1/2) Calcineurin-like phosphoesterase
GCF_000935125.1	1350.92 +- 1370.79	3	0	0	0.01 +- 0.00	3	No common domains found
GCF_001279905.1	1935.00 +- 0.00	1	0	0	0.01 +- 0.00	1	15 TIGR01426 (1/1) glycosyltransferase, MGT family PF17914 (1/1) HopA1 effector protein family PF13692 (1/1) Glycosyl transferases group 1 PF13601 (1/1) Winged helix DNA-binding domain PF12698 (1/1) ABC-2 family transporter protein PF05719 (1/1) Golgi phosphoprotein 3 (GPP34) PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF01636 (1/1) Phosphotransferase enzyme family PF00891 (1/1) O-methyltransferase domain PF00675 (1/1) Insulinase (Peptidase family M16) PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase PF00005 (1/1) ABC transporter
GCF_000156455.1	668.57 +- 0.00	1	1	1	0.03 +- 0.01	1	8 TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF13575 (1/1) Domain of unknown function (DUF4135) PF12679 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_002891315.1	460.58 +- 358.07	6	3	0	0.03 +- 0.04	6	No common domains found
GCF_000240165.1	228.93 +- 0.00	1	1	0	0.08 +- 0.26	1	18 TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain TIGR00976 (1/1) hydrolase CocE/NonD family protein TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF16911 (1/1) Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus PF13581 (1/1) Histidine kinase-like ATPase domain PF12911 (1/1) N-terminal TM domain of oligopeptide transport permease C PF09339 (1/1) IclR helix-turn-helix domain PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region PF07690 (1/1) Major Facilitator Superfamily PF03328 (1/1) HpcH/HpaI aldolase/citrate lyase family PF02515 (1/1) CoA-transferase family III PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family) PF01614 (1/1) Bacterial transcriptional regulator PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00005 (1/1) ABC transporter
GCF_002188335.1	561.83 +- 388.08	2	1	0	0.04 +- 0.12	2	26 PF00682 (2/2) HMGL-like PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase TIGR01733 (1/2) amino acid adenylation domain TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720 TIGR00710 (1/2) drug resistance transporter, Bcr/CflA subfamily TIGR00171 (1/2) 3-isopropylmalate dehydratase, small subunit TIGR00170 (1/2) 3-isopropylmalate dehydratase, large subunit TIGR00169 (1/2) 3-isopropylmalate dehydrogenase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF11806 (1/2) Domain of unknown function (DUF3327) PF08242 (1/2) Methyltransferase domain PF07690 (1/2) Major Facilitator Superfamily PF03737 (1/2) Aldolase/RraA PF03621 (1/2) MbtH-like protein PF03466 (1/2) LysR substrate binding domain PF01361 (1/2) Tautomerase enzyme PF00994 (1/2) Probable molybdopterin binding domain PF00756 (1/2) Putative esterase PF00694 (1/2) Aconitase C-terminal domain PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00330 (1/2) Aconitase family (aconitate hydratase) PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00155 (1/2) Aminotransferase class I and II PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
GCF_002155725.1	423.30 +- 226.81	3	2	0	0.02 +- 0.02	3	1 PF00561 (2/3) alpha/beta hydrolase fold
GCF_003688995.1	780.73 +- 530.82	5	0	0	0.03 +- 0.10	5	3 PF08402 (3/5) TOBE domain PF00528 (3/5) Binding-protein-dependent transport system inner membrane component PF00005 (3/5) ABC transporter
GCF_001746455.1	1197.28 +- 1112.33	2	2	0	0.03 +- 0.05	2	48 TIGR02965 (1/2) xanthine dehydrogenase, molybdopterin binding subunit TIGR02964 (1/2) xanthine dehydrogenase accessory protein XdhC TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (1/2) diaminopimelate epimerase PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF14518 (1/2) Iron-containing redox enzyme PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal PF13560 (1/2) Helix-turn-helix domain PF13535 (1/2) ATP-grasp domain PF13478 (1/2) XdhC Rossmann domain PF13458 (1/2) Periplasmic binding protein PF13367 (1/2) PrsW family intramembrane metalloprotease PF13302 (1/2) Acetyltransferase (GNAT) domain PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter PF10014 (1/2) 2OG-Fe dioxygenase PF08241 (1/2) Methyltransferase domain PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (1/2) Aminopeptidase P, N-terminal domain PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02625 (1/2) XdhC and CoxI family PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF02153 (1/2) Prephenate dehydrogenase PF01799 (1/2) [2Fe-2S] binding domain PF01678 (1/2) Diaminopimelate epimerase PF01575 (1/2) MaoC like domain PF01568 (1/2) Molydopterin dinucleotide binding domain PF01425 (1/2) Amidase PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF01070 (1/2) FMN-dependent dehydrogenase PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (1/2) EamA-like transporter family PF00756 (1/2) Putative esterase PF00682 (1/2) HMGL-like PF00557 (1/2) Metallopeptidase family M24 PF00384 (1/2) Molybdopterin oxidoreductase PF00248 (1/2) Aldo/keto reductase family PF00155 (1/2) Aminotransferase class I and II PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain PF00005 (1/2) ABC transporter
GCF_002300165.1	46.36 +- 0.83	2	0	1	0.06 +- 0.11	2	20 TIGR04269 (1/2) radical SAM/SPASM domain protein, FxsB family TIGR04268 (1/2) FXSXX-COOH protein TIGR04267 (1/2) HEXXH motif domain TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family PF17964 (1/2) Bacterial Ig domain PF14864 (1/2) Alkyl sulfatase C-terminal PF14863 (1/2) Alkyl sulfatase dimerisation PF13676 (1/2) TIR domain PF13424 (1/2) Tetratricopeptide repeat PF13374 (1/2) Tetratricopeptide repeat PF13365 (1/2) Trypsin-like peptidase domain PF12680 (1/2) SnoaL-like domain PF08281 (1/2) Sigma-70, region 4 PF04542 (1/2) Sigma-70 region 2 PF04055 (1/2) Radical SAM superfamily PF03734 (1/2) L,D-transpeptidase catalytic domain PF01361 (1/2) Tautomerase enzyme PF00931 (1/2) NB-ARC domain PF00912 (1/2) Transglycosylase PF00753 (1/2) Metallo-beta-lactamase superfamily
GCF_001905445.1	617.78 +- 387.08	2	0	0	0.04 +- 0.03	2	25 TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating) PF17874 (1/2) MalT-like TPR region PF13621 (1/2) Cupin-like domain PF13560 (1/2) Helix-turn-helix domain PF13393 (1/2) Histidyl-tRNA synthetase PF13191 (1/2) AAA ATPase domain PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation PF07836 (1/2) DmpG-like communication domain PF07690 (1/2) Major Facilitator Superfamily PF05193 (1/2) Peptidase M16 inactive domain PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF02585 (1/2) GlcNAc-PI de-N-acetylase PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF01370 (1/2) NAD dependent epimerase/dehydratase family PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF01061 (1/2) ABC-2 type transporter PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain PF00682 (1/2) HMGL-like PF00675 (1/2) Insulinase (Peptidase family M16) PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00155 (1/2) Aminotransferase class I and II PF00005 (1/2) ABC transporter
GCF_000935135.2	212.13 +- 239.29	3	2	0	0.04 +- 0.03	3	No common domains found
GCF_001650215.1	179.24 +- 103.00	4	0	1	0.05 +- 0.08	4	No common domains found
GCF_003265665.1	2797.24 +- 0.00	1	1	1	0.02 +- 0.01	1	8 TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (1/1) ABC-2 type transporter PF00881 (1/1) Nitroreductase family PF00005 (1/1) ABC transporter
GCF_001748085.1	855.53 +- 692.47	2	0	0	0.07 +- 0.21	2	24 PF13377 (1/2) Periplasmic binding protein-like domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF13183 (1/2) 4Fe-4S dicluster domain PF12697 (1/2) Alpha/beta hydrolase family PF09339 (1/2) IclR helix-turn-helix domain PF07090 (1/2) Putative glutamine amidotransferase PF04072 (1/2) Leucine carboxyl methyltransferase PF03069 (1/2) Acetamidase/Formamidase family PF02913 (1/2) FAD linked oxidases, C-terminal domain PF02754 (1/2) Cysteine-rich domain PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02608 (1/2) ABC transporter substrate-binding protein PnrA-like PF02515 (1/2) CoA-transferase family III PF01614 (1/2) Bacterial transcriptional regulator PF01565 (1/2) FAD binding domain PF01266 (1/2) FAD dependent oxidoreductase PF01156 (1/2) Inosine-uridine preferring nucleoside hydrolase PF01144 (1/2) Coenzyme A transferase PF00501 (1/2) AMP-binding enzyme PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00294 (1/2) pfkB family carbohydrate kinase PF00171 (1/2) Aldehyde dehydrogenase family PF00005 (1/2) ABC transporter
GCF_000720885.1	43.00 +- 0.00	1	0	0	0.07 +- 0.10	1	5 PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (1/1) [2Fe-2S] binding domain PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
GCF_000745345.1	258.00 +- 0.00	1	1	0	0.01 +- 0.00	1	6 PF14015 (1/1) Protein of unknown function (DUF4231) PF08244 (1/1) Glycosyl hydrolases family 32 C terminal PF04314 (1/1) Copper chaperone PCu(A)C PF01674 (1/1) Lipase (class 2) PF01435 (1/1) Peptidase family M48 PF00251 (1/1) Glycosyl hydrolases family 32 N-terminal domain
GCF_900091765.1	376.34 +- 93.94	2	0	0	0.04 +- 0.01	2	28 TIGR03561 (1/2) peroxiredoxin, Ohr subfamily TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13649 (1/2) Methyltransferase domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF09339 (1/2) IclR helix-turn-helix domain PF09084 (1/2) NMT1/THI5 like PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF04199 (1/2) Putative cyclase PF03972 (1/2) MmgE/PrpD family PF03781 (1/2) Sulfatase-modifying factor enzyme 1 PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF02566 (1/2) OsmC-like protein PF02515 (1/2) CoA-transferase family III PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (1/2) Phosphotriesterase family PF01979 (1/2) Amidohydrolase family PF01614 (1/2) Bacterial transcriptional regulator PF01546 (1/2) Peptidase family M20/M25/M40 PF01494 (1/2) FAD binding domain PF00884 (1/2) Sulfatase PF00753 (1/2) Metallo-beta-lactamase superfamily PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family PF00561 (1/2) alpha/beta hydrolase fold PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00005 (1/2) ABC transporter
GCF_000720395.1	404.44 +- 0.00	1	1	1	0.02 +- 0.01	1	7 PF07690 (1/1) Major Facilitator Superfamily PF04055 (1/1) Radical SAM superfamily PF03466 (1/1) LysR substrate binding domain PF02310 (1/1) B12 binding domain PF00733 (1/1) Asparagine synthase PF00501 (1/1) AMP-binding enzyme PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
GCF_000720115.1	2655.62 +- 2375.38	2	0	0	0.01 +- 0.01	2	23 PF17914 (1/2) HopA1 effector protein family PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain PF13732 (1/2) Domain of unknown function (DUF4162) PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12802 (1/2) MarR family PF12698 (1/2) ABC-2 family transporter protein PF07690 (1/2) Major Facilitator Superfamily PF07676 (1/2) WD40-like Beta Propeller Repeat PF05193 (1/2) Peptidase M16 inactive domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF02441 (1/2) Flavoprotein PF02225 (1/2) PA domain PF01636 (1/2) Phosphotransferase enzyme family PF00891 (1/2) O-methyltransferase domain PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00501 (1/2) AMP-binding enzyme PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00296 (1/2) Luciferase-like monooxygenase PF00171 (1/2) Aldehyde dehydrogenase family PF00082 (1/2) Subtilase family PF00069 (1/2) Protein kinase domain PF00005 (1/2) ABC transporter
GCF_000372745.1	344.33 +- 273.07	3	1	0	0.06 +- 0.22	3	No common domains found
GCF_002224125.1	241.32 +- 123.64	7	3	3	0.03 +- 0.06	7	No common domains found
GCF_000716675.1	197.29 +- 60.71	2	1	0	0.02 +- 0.03	2	15 PF13193 (2/2) AMP-binding enzyme C-terminal domain PF00501 (2/2) AMP-binding enzyme TIGR01733 (1/2) amino acid adenylation domain TIGR01297 (1/2) cation diffusion facilitator family transporter PF12680 (1/2) SnoaL-like domain PF08242 (1/2) Methyltransferase domain PF07883 (1/2) Cupin domain PF02031 (1/2) Streptomyces extracellular neutral proteinase (M7) family PF01695 (1/2) IstB-like ATP binding protein PF01545 (1/2) Cation efflux family PF00975 (1/2) Thioesterase domain PF00668 (1/2) Condensation domain PF00665 (1/2) Integrase core domain PF00550 (1/2) Phosphopantetheine attachment site PF00221 (1/2) Aromatic amino acid lyase
GCF_001419745.1	50.17 +- 7.17	2	1	0	0.05 +- 0.05	2	12 PF17874 (1/2) MalT-like TPR region PF14534 (1/2) Domain of unknown function (DUF4440) PF13560 (1/2) Helix-turn-helix domain PF13432 (1/2) Tetratricopeptide repeat PF12697 (1/2) Alpha/beta hydrolase family PF08002 (1/2) Protein of unknown function (DUF1697) PF07063 (1/2) Domain of unknown function (DUF1338) PF05922 (1/2) Peptidase inhibitor I9 PF01323 (1/2) DSBA-like thioredoxin domain PF01266 (1/2) FAD dependent oxidoreductase PF00171 (1/2) Aldehyde dehydrogenase family PF00082 (1/2) Subtilase family
GCF_000177195.2	360.86 +- 245.80	2	2	0	0.04 +- 0.06	2	24 TIGR01891 (1/2) amidohydrolase TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01821 (1/2) 5-aminolevulinic acid synthase TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF16884 (1/2) N-terminal domain of oxidoreductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08443 (1/2) RimK-like ATP-grasp domain PF07690 (1/2) Major Facilitator Superfamily PF03466 (1/2) LysR substrate binding domain PF02780 (1/2) Transketolase, C-terminal domain PF02779 (1/2) Transketolase, pyrimidine binding domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (1/2) Peptidase family M20/M25/M40 PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00501 (1/2) AMP-binding enzyme PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00155 (1/2) Aminotransferase class I and II PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00107 (1/2) Zinc-binding dehydrogenase
GCF_001905905.1	22.03 +- 0.00	1	0	0	0.09 +- 0.19	1	19 TIGR03638 (1/1) CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI TIGR02548 (1/1) CRISPR type I-E/ECOLI-associated protein CasB/Cse2 TIGR02547 (1/1) CRISPR type I-E/ECOLI-associated protein CasA/Cse1 TIGR01907 (1/1) CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI TIGR01873 (1/1) CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI TIGR01869 (1/1) CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI TIGR01868 (1/1) CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI TIGR01596 (1/1) CRISPR-associated endonuclease Cas3-HD TIGR01587 (1/1) CRISPR-associated helicase Cas3 PF18395 (1/1) Cas3 C-terminal domain PF18019 (1/1) HD domain PF09707 (1/1) CRISPR-associated protein (Cas_Cas2CT1978) PF09704 (1/1) CRISPR-associated protein (Cas_Cas5) PF09485 (1/1) CRISPR-associated protein Cse2 (CRISPR_cse2) PF09481 (1/1) CRISPR-associated protein Cse1 (CRISPR_cse1) PF09344 (1/1) CT1975-like protein PF08798 (1/1) CRISPR associated protein PF07876 (1/1) Stress responsive A/B Barrel Domain PF05685 (1/1) Putative restriction endonuclease
GCF_900091745.1	301.05 +- 23.95	2	0	1	0.02 +- 0.02	2	12 PF07690 (2/2) Major Facilitator Superfamily TIGR00976 (1/2) hydrolase CocE/NonD family protein PF13649 (1/2) Methyltransferase domain PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07859 (1/2) alpha/beta hydrolase fold PF04055 (1/2) Radical SAM superfamily PF03781 (1/2) Sulfatase-modifying factor enzyme 1 PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF02126 (1/2) Phosphotriesterase family PF01494 (1/2) FAD binding domain PF00884 (1/2) Sulfatase PF00753 (1/2) Metallo-beta-lactamase superfamily
GCF_004187715.1	471.39 +- 439.62	3	1	0	0.05 +- 0.14	3	1 PF00005 (2/3) ABC transporter
GCF_000968255.1	304.63 +- 206.48	4	2	0	0.03 +- 0.05	4	1 PF07690 (3/4) Major Facilitator Superfamily
GCF_003851625.1	1350.51 +- 1605.33	3	2	1	0.02 +- 0.03	3	1 PF00005 (2/3) ABC transporter
GCF_000772895.1	30.35 +- 0.00	1	0	0	0.07 +- 0.03	1	1 PF00069 (1/1) Protein kinase domain
GCF_002705685.1	2080.00 +- 0.00	1	1	1	0.01 +- 0.00	1	8 TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF13575 (1/1) Domain of unknown function (DUF4135) PF12679 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_002907485.1	455.00 +- 0.00	1	1	0	0.05 +- 0.02	1	18 TIGR00976 (1/1) hydrolase CocE/NonD family protein PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13193 (1/1) AMP-binding enzyme C-terminal domain PF12697 (1/1) Alpha/beta hydrolase family PF12679 (1/1) ABC-2 family transporter protein PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF04909 (1/1) Amidohydrolase PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family) PF01144 (1/1) Coenzyme A transferase PF00501 (1/1) AMP-binding enzyme PF00378 (1/1) Enoyl-CoA hydratase/isomerase PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain PF00106 (1/1) short chain dehydrogenase PF00005 (1/1) ABC transporter
GCF_003324565.1	207.63 +- 180.71	4	3	1	0.04 +- 0.05	4	1 PF00583 (2/4) Acetyltransferase (GNAT) family
GCF_001866675.1	830.34 +- 623.33	3	2	2	0.05 +- 0.13	3	1 PF07690 (2/3) Major Facilitator Superfamily
GCF_000373565.1	156.00 +- 0.00	1	0	0	0.01 +- 0.01	1	6 PF17103 (1/1) Stealth protein CR4, conserved region 4 PF17102 (1/1) Stealth protein CR3, conserved region 3 PF17101 (1/1) Stealth protein CR1, conserved region 1 PF13091 (1/1) PLD-like domain PF11380 (1/1) Stealth protein CR2, conserved region 2 PF07859 (1/1) alpha/beta hydrolase fold
GCF_000745675.1	291.95 +- 313.08	5	0	0	0.03 +- 0.11	5	No common domains found
GCF_000158895.1	365.53 +- 162.02	3	2	1	0.02 +- 0.02	3	1 PF07690 (2/3) Major Facilitator Superfamily
GCF_001531145.1	37.22 +- 2.82	2	0	0	0.07 +- 0.13	2	7 TIGR03707 (1/2) polyphosphate kinase 2 PF12802 (1/2) MarR family PF11239 (1/2) Protein of unknown function (DUF3040) PF04231 (1/2) Endonuclease I PF03976 (1/2) Polyphosphate kinase 2 (PPK2) PF03301 (1/2) Tryptophan 2,3-dioxygenase PF01425 (1/2) Amidase
GCF_000716025.1	228.40 +- 239.32	5	3	2	0.06 +- 0.07	5	No common domains found
GCF_900091775.1	221.11 +- 182.02	2	0	0	0.06 +- 0.04	2	23 TIGR00976 (1/2) hydrolase CocE/NonD family protein PF16656 (1/2) Purple acid Phosphatase, N-terminal domain PF13795 (1/2) HupE / UreJ protein PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12679 (1/2) ABC-2 family transporter protein PF12146 (1/2) Serine aminopeptidase, S33 PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF06030 (1/2) Bacterial protein of unknown function (DUF916) PF04909 (1/2) Amidohydrolase PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01144 (1/2) Coenzyme A transferase PF00501 (1/2) AMP-binding enzyme PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00149 (1/2) Calcineurin-like phosphoesterase PF00132 (1/2) Bacterial transferase hexapeptide (six repeats) PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00106 (1/2) short chain dehydrogenase PF00005 (1/2) ABC transporter
GCF_000482585.1	644.20 +- 346.40	3	2	0	0.04 +- 0.17	3	2 PF00528 (2/3) Binding-protein-dependent transport system inner membrane component PF00005 (2/3) ABC transporter
GCF_000718985.1	423.08 +- 21.75	2	1	0	0.02 +- 0.03	2	23 TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF13459 (1/2) 4Fe-4S single cluster domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08443 (1/2) RimK-like ATP-grasp domain PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase PF07729 (1/2) FCD domain PF07722 (1/2) Peptidase C26 PF03466 (1/2) LysR substrate binding domain PF02780 (1/2) Transketolase, C-terminal domain PF02779 (1/2) Transketolase, pyrimidine binding domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00501 (1/2) AMP-binding enzyme PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3 PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00392 (1/2) Bacterial regulatory proteins, gntR family PF00171 (1/2) Aldehyde dehydrogenase family PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00120 (1/2) Glutamine synthetase, catalytic domain PF00067 (1/2) Cytochrome P450
GCF_001270565.1	258.72 +- 14.97	2	1	0	0.06 +- 0.16	2	17 TIGR03797 (1/2) NHLM bacteriocin system ABC transporter, ATP-binding protein TIGR03796 (1/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein PF13459 (1/2) 4Fe-4S single cluster domain PF13437 (1/2) HlyD family secretion protein PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport PF10589 (1/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PF08386 (1/2) TAP-like protein PF07690 (1/2) Major Facilitator Superfamily PF05013 (1/2) N-formylglutamate amidohydrolase PF03640 (1/2) Secreted repeat of unknown function PF03412 (1/2) Peptidase C39 family PF03055 (1/2) Retinal pigment epithelial membrane protein PF01512 (1/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit PF00664 (1/2) ABC transporter transmembrane region PF00561 (1/2) alpha/beta hydrolase fold PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00005 (1/2) ABC transporter
GCF_001646665.1	57.33 +- 0.00	1	1	0	0.05 +- 0.07	1	4 PF07690 (1/1) Major Facilitator Superfamily PF03621 (1/1) MbtH-like protein PF01019 (1/1) Gamma-glutamyltranspeptidase PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
GCF_900129855.1	291.86 +- 377.70	5	1	1	0.04 +- 0.06	5	No common domains found
GCF_001418545.1	62.40 +- 0.00	1	0	0	0.05 +- 0.07	1	5 PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase PF01799 (1/1) [2Fe-2S] binding domain PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
GCF_000373225.1	422.68 +- 0.00	1	1	1	0.07 +- 0.08	1	12 TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/1) SagB-type dehydrogenase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF13191 (1/1) AAA ATPase domain PF04738 (1/1) Lantibiotic dehydratase, N terminus PF03704 (1/1) Bacterial transcriptional activator domain PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (1/1) ABC-2 type transporter PF00881 (1/1) Nitroreductase family PF00486 (1/1) Transcriptional regulatory protein, C terminal PF00005 (1/1) ABC transporter
GCF_001049855.1	263.86 +- 198.86	2	0	0	0.04 +- 0.03	2	18 TIGR00843 (1/2) benzoate transporter PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF13535 (1/2) ATP-grasp domain PF12833 (1/2) Helix-turn-helix domain PF10994 (1/2) Protein of unknown function (DUF2817) PF07690 (1/2) Major Facilitator Superfamily PF03594 (1/2) Benzoate membrane transport protein PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/2) DJ-1/PfpI family PF01925 (1/2) Sulfite exporter TauE/SafE PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF01070 (1/2) FMN-dependent dehydrogenase PF00696 (1/2) Amino acid kinase family PF00465 (1/2) Iron-containing alcohol dehydrogenase PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00171 (1/2) Aldehyde dehydrogenase family PF00155 (1/2) Aminotransferase class I and II
GCF_000721665.1	112.10 +- 53.96	5	2	1	0.04 +- 0.05	5	No common domains found
GCF_002154505.1	125.71 +- 40.75	3	0	0	0.03 +- 0.04	3	No common domains found
GCF_003248335.1	691.82 +- 241.84	4	3	2	0.01 +- 0.01	4	3 PF07690 (3/4) Major Facilitator Superfamily PF02668 (2/4) Taurine catabolism dioxygenase TauD, TfdA family PF02310 (2/4) B12 binding domain
GCF_003384865.1	260.00 +- 0.00	1	0	0	0.02 +- 0.02	1	3 PF13365 (1/1) Trypsin-like peptidase domain PF00400 (1/1) WD domain, G-beta repeat PF00248 (1/1) Aldo/keto reductase family
GCF_000718945.1	127.31 +- 62.83	3	0	0	0.04 +- 0.08	3	No common domains found
GCF_000725465.1	94.55 +- 0.00	1	1	0	0.02 +- 0.01	1	4 PF04073 (1/1) Aminoacyl-tRNA editing domain PF01116 (1/1) Fructose-bisphosphate aldolase class-II PF00892 (1/1) EamA-like transporter family PF00464 (1/1) Serine hydroxymethyltransferase
GCF_000721085.1	44.23 +- 0.00	1	1	1	0.07 +- 0.00	1	3 PF13471 (1/1) Transglutaminase-like superfamily PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (1/1) Asparagine synthase
GCF_002705695.1	157.05 +- 94.21	3	1	2	0.04 +- 0.02	3	1 PF07690 (2/3) Major Facilitator Superfamily
GCF_000961885.1	45.27 +- 2.61	3	1	0	0.06 +- 0.07	3	No common domains found
GCF_001419795.1	32.50 +- 0.00	1	0	0	0.06 +- 0.05	1	3 PF13602 (1/1) Zinc-binding dehydrogenase PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF00106 (1/1) short chain dehydrogenase
GCF_000932225.2	558.52 +- 221.48	2	1	1	0.03 +- 0.02	2	12 PF00005 (2/2) ABC transporter PF17914 (1/2) HopA1 effector protein family PF13649 (1/2) Methyltransferase domain PF05193 (1/2) Peptidase M16 inactive domain PF05147 (1/2) Lanthionine synthetase C-like protein PF04672 (1/2) S-adenosyl methyltransferase PF02441 (1/2) Flavoprotein PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00326 (1/2) Prolyl oligopeptidase family PF00296 (1/2) Luciferase-like monooxygenase PF00069 (1/2) Protein kinase domain
GCF_000497425.1	1917.50 +- 942.50	2	0	1	0.01 +- 0.00	2	22 TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/2) SagB-type dehydrogenase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13416 (1/2) Bacterial extracellular solute-binding protein PF08402 (1/2) TOBE domain PF08241 (1/2) Methyltransferase domain PF07993 (1/2) Male sterility protein PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport PF03176 (1/2) MMPL family PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01575 (1/2) MaoC like domain PF00962 (1/2) Adenosine/AMP deaminase PF00881 (1/2) Nitroreductase family PF00698 (1/2) Acyl transferase domain PF00550 (1/2) Phosphopantetheine attachment site PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00202 (1/2) Aminotransferase class-III PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (1/2) ABC transporter
GCF_002943895.1	247.33 +- 247.25	3	1	0	0.05 +- 0.16	3	No common domains found
GCF_000717105.1	582.45 +- 191.55	2	1	1	0.01 +- 0.01	2	24 TIGR01558 (1/2) putative phage terminase, small subunit, P27 family TIGR01554 (1/2) phage major capsid protein, HK97 family TIGR01543 (1/2) phage prohead protease, HK97 family TIGR01537 (1/2) phage portal protein, HK97 family PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein PF10145 (1/2) Phage-related minor tail protein PF05147 (1/2) Lanthionine synthetase C-like protein PF05119 (1/2) Phage terminase, small subunit PF05065 (1/2) Phage capsid family PF04860 (1/2) Phage portal protein PF04851 (1/2) Type III restriction enzyme, res subunit PF04672 (1/2) S-adenosyl methyltransferase PF04586 (1/2) Caudovirus prohead serine protease PF04542 (1/2) Sigma-70 region 2 PF03354 (1/2) Phage Terminase PF01844 (1/2) HNH endonuclease PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF01391 (1/2) Collagen triple helix repeat (20 copies) PF01381 (1/2) Helix-turn-helix PF00664 (1/2) ABC transporter transmembrane region PF00326 (1/2) Prolyl oligopeptidase family PF00271 (1/2) Helicase conserved C-terminal domain PF00069 (1/2) Protein kinase domain PF00005 (1/2) ABC transporter
GCF_000010605.1	77.40 +- 0.00	1	0	0	0.05 +- 0.05	1	5 PF14103 (1/1) Domain of unknown function (DUF4276) PF13304 (1/1) AAA domain, putative AbiEii toxin, Type IV TA system PF04101 (1/1) Glycosyltransferase family 28 C-terminal domain PF03033 (1/1) Glycosyltransferase family 28 N-terminal domain PF02463 (1/1) RecF/RecN/SMC N terminal domain
GCF_003330865.1	308.79 +- 212.61	4	0	0	0.04 +- 0.13	4	No common domains found
GCF_000719815.1	383.45 +- 132.55	2	0	1	0.05 +- 0.04	2	32 TIGR04364 (1/2) methyltransferase, FxLD system TIGR04363 (1/2) FxLD family lantipeptide TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF13671 (1/2) AAA domain PF13560 (1/2) Helix-turn-helix domain PF11723 (1/2) Homotrimeric ring hydroxylase PF05331 (1/2) Protein of unknown function (DUF742) PF05147 (1/2) Lanthionine synthetase C-like protein PF04738 (1/2) Lantibiotic dehydratase, N terminus PF03972 (1/2) MmgE/PrpD family PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent PF03259 (1/2) Roadblock/LC7 domain PF03029 (1/2) Conserved hypothetical ATP binding protein PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF01590 (1/2) GAF domain PF01546 (1/2) Peptidase family M20/M25/M40 PF01427 (1/2) D-ala-D-ala dipeptidase PF01327 (1/2) Polypeptide deformylase PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00723 (1/2) Glycosyl hydrolases family 15 PF00561 (1/2) alpha/beta hydrolase fold PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00355 (1/2) Rieske [2Fe-2S] domain PF00296 (1/2) Luciferase-like monooxygenase PF00293 (1/2) NUDIX domain PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain PF00005 (1/2) ABC transporter
GCF_001418505.1	344.00 +- 0.00	1	0	0	0.01 +- 0.01	1	7 PF14759 (1/1) Reductase C-terminal PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase PF07690 (1/1) Major Facilitator Superfamily PF04237 (1/1) YjbR PF00067 (1/1) Cytochrome P450
GCF_000719475.1	212.72 +- 96.88	2	1	1	0.07 +- 0.10	2	21 TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family TIGR01525 (1/2) heavy metal translocating P-type ATPase PF17197 (1/2) Domain of unknown function (DUF5134) PF14867 (1/2) Lantibiotic alpha PF13575 (1/2) Domain of unknown function (DUF4135) PF08281 (1/2) Sigma-70, region 4 PF05147 (1/2) Lanthionine synthetase C-like protein PF04542 (1/2) Sigma-70 region 2 PF04314 (1/2) Copper chaperone PCu(A)C PF03929 (1/2) PepSY-associated TM region PF03551 (1/2) Transcriptional regulator PadR-like family PF03412 (1/2) Peptidase C39 family PF01965 (1/2) DJ-1/PfpI family PF01569 (1/2) PAP2 superfamily PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00664 (1/2) ABC transporter transmembrane region PF00403 (1/2) Heavy-metal-associated domain PF00296 (1/2) Luciferase-like monooxygenase PF00122 (1/2) E1-E2 ATPase PF00005 (1/2) ABC transporter
GCF_000968685.2	268.67 +- 34.67	2	0	0	0.05 +- 0.07	2	19 TIGR00976 (2/2) hydrolase CocE/NonD family protein PF13193 (2/2) AMP-binding enzyme C-terminal domain PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07690 (2/2) Major Facilitator Superfamily PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family) PF00501 (2/2) AMP-binding enzyme TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family PF13378 (1/2) Enolase C-terminal domain-like PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family PF01425 (1/2) Amidase PF01244 (1/2) Membrane dipeptidase (Peptidase family M19) PF01230 (1/2) HIT domain PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain PF00583 (1/2) Acetyltransferase (GNAT) family PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3 PF00296 (1/2) Luciferase-like monooxygenase PF00005 (1/2) ABC transporter
GCF_900105235.1	110.58 +- 75.13	2	0	0	0.05 +- 0.06	2	9 PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif PF05331 (1/2) Protein of unknown function (DUF742) PF04149 (1/2) Domain of unknown function (DUF397) PF03713 (1/2) Domain of unknown function (DUF305) PF03259 (1/2) Roadblock/LC7 domain PF03029 (1/2) Conserved hypothetical ATP binding protein PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain PF00067 (1/2) Cytochrome P450
GCF_900091975.1	276.98 +- 327.62	4	2	0	0.05 +- 0.09	4	3 PF07690 (3/4) Major Facilitator Superfamily PF08281 (2/4) Sigma-70, region 4 PF04542 (2/4) Sigma-70 region 2
GCF_001969965.1	393.32 +- 173.95	2	2	1	0.03 +- 0.04	2	22 TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM TIGR01534 (1/2) glyceraldehyde-3-phosphate dehydrogenase, type I PF14867 (1/2) Lantibiotic alpha PF13575 (1/2) Domain of unknown function (DUF4135) PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13450 (1/2) NAD(P)-binding Rossmann-like domain PF07690 (1/2) Major Facilitator Superfamily PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF05147 (1/2) Lanthionine synthetase C-like protein PF03936 (1/2) Terpene synthase family, metal binding domain PF03704 (1/2) Bacterial transcriptional activator domain PF03412 (1/2) Peptidase C39 family PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family PF02800 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF00664 (1/2) ABC transporter transmembrane region PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00348 (1/2) Polyprenyl synthetase PF00106 (1/2) short chain dehydrogenase PF00067 (1/2) Cytochrome P450 PF00044 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain PF00005 (1/2) ABC transporter
GCF_001723075.1	967.50 +- 0.00	1	0	0	0.01 +- 0.00	1	5 PF13416 (1/1) Bacterial extracellular solute-binding protein PF08402 (1/1) TOBE domain PF00962 (1/1) Adenosine/AMP deaminase PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00005 (1/1) ABC transporter
GCF_001746475.1	471.89 +- 410.47	2	2	0	0.05 +- 0.14	2	48 TIGR02965 (1/2) xanthine dehydrogenase, molybdopterin binding subunit TIGR02964 (1/2) xanthine dehydrogenase accessory protein XdhC TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (1/2) diaminopimelate epimerase PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF14518 (1/2) Iron-containing redox enzyme PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal PF13560 (1/2) Helix-turn-helix domain PF13535 (1/2) ATP-grasp domain PF13478 (1/2) XdhC Rossmann domain PF13458 (1/2) Periplasmic binding protein PF13367 (1/2) PrsW family intramembrane metalloprotease PF13302 (1/2) Acetyltransferase (GNAT) domain PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter PF10014 (1/2) 2OG-Fe dioxygenase PF08241 (1/2) Methyltransferase domain PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (1/2) Aminopeptidase P, N-terminal domain PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02625 (1/2) XdhC and CoxI family PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF02153 (1/2) Prephenate dehydrogenase PF01799 (1/2) [2Fe-2S] binding domain PF01678 (1/2) Diaminopimelate epimerase PF01575 (1/2) MaoC like domain PF01568 (1/2) Molydopterin dinucleotide binding domain PF01425 (1/2) Amidase PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF01070 (1/2) FMN-dependent dehydrogenase PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (1/2) EamA-like transporter family PF00756 (1/2) Putative esterase PF00682 (1/2) HMGL-like PF00557 (1/2) Metallopeptidase family M24 PF00384 (1/2) Molybdopterin oxidoreductase PF00248 (1/2) Aldo/keto reductase family PF00155 (1/2) Aminotransferase class I and II PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain PF00005 (1/2) ABC transporter
GCF_002754595.1	3405.60 +- 0.00	1	0	0	0.01 +- 0.01	1	13 TIGR01263 (1/1) 4-hydroxyphenylpyruvate dioxygenase PF18603 (1/1) L-amino acid ligase C-terminal domain 2 PF18130 (1/1) ATP-grasp N-terminal domain PF14696 (1/1) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal PF13535 (1/1) ATP-grasp domain PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH) PF02153 (1/1) Prephenate dehydrogenase PF01613 (1/1) Flavin reductase like domain PF01070 (1/1) FMN-dependent dehydrogenase PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00296 (1/1) Luciferase-like monooxygenase PF00155 (1/1) Aminotransferase class I and II PF00106 (1/1) short chain dehydrogenase
GCF_001642995.1	260.90 +- 42.29	3	0	1	0.05 +- 0.07	3	No common domains found
GCF_001905425.1	581.24 +- 685.62	5	2	1	0.03 +- 0.03	5	No common domains found
GCF_000154945.1	425.45 +- 0.00	1	0	0	0.04 +- 0.02	1	16 TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family PF18603 (1/1) L-amino acid ligase C-terminal domain 2 PF18130 (1/1) ATP-grasp N-terminal domain PF13535 (1/1) ATP-grasp domain PF08443 (1/1) RimK-like ATP-grasp domain PF07690 (1/1) Major Facilitator Superfamily PF02779 (1/1) Transketolase, pyrimidine binding domain PF02774 (1/1) Semialdehyde dehydrogenase, dimerisation domain PF01546 (1/1) Peptidase family M20/M25/M40 PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (1/1) Amino acid kinase family PF00456 (1/1) Transketolase, thiamine diphosphate binding domain PF00196 (1/1) Bacterial regulatory proteins, luxR family
GCF_002844215.1	451.50 +- 193.50	2	0	0	0.01 +- 0.00	2	10 PF00561 (2/2) alpha/beta hydrolase fold PF12697 (1/2) Alpha/beta hydrolase family PF11723 (1/2) Homotrimeric ring hydroxylase PF08386 (1/2) TAP-like protein PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase PF01546 (1/2) Peptidase family M20/M25/M40 PF01471 (1/2) Putative peptidoglycan binding domain PF00355 (1/2) Rieske [2Fe-2S] domain PF00175 (1/2) Oxidoreductase NAD-binding domain PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
GCF_000154965.1	367.58 +- 597.28	5	1	1	0.05 +- 0.10	5	No common domains found
GCF_001011035.1	611.99 +- 391.33	6	3	0	0.01 +- 0.01	6	No common domains found
GCF_000176115.2	485.33 +- 0.00	1	1	1	0.01 +- 0.00	1	7 PF07690 (1/1) Major Facilitator Superfamily PF04055 (1/1) Radical SAM superfamily PF03466 (1/1) LysR substrate binding domain PF02310 (1/1) B12 binding domain PF00733 (1/1) Asparagine synthase PF00501 (1/1) AMP-binding enzyme PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
GCF_001270485.1	367.21 +- 79.01	3	1	0	0.02 +- 0.01	3	No common domains found
GCF_000721305.1	358.89 +- 216.13	3	0	1	0.02 +- 0.02	3	No common domains found
GCF_001282115.1	838.50 +- 709.50	2	1	0	0.01 +- 0.00	2	11 TIGR00976 (1/2) hydrolase CocE/NonD family protein PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08007 (1/2) Cupin superfamily protein PF03412 (1/2) Peptidase C39 family PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01464 (1/2) Transglycosylase SLT domain PF00668 (1/2) Condensation domain PF00664 (1/2) ABC transporter transmembrane region PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00005 (1/2) ABC transporter
GCF_003259575.1	216.34 +- 127.66	2	2	0	0.05 +- 0.09	2	24 TIGR01891 (1/2) amidohydrolase TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01821 (1/2) 5-aminolevulinic acid synthase TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF16884 (1/2) N-terminal domain of oxidoreductase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08443 (1/2) RimK-like ATP-grasp domain PF07690 (1/2) Major Facilitator Superfamily PF03466 (1/2) LysR substrate binding domain PF02780 (1/2) Transketolase, C-terminal domain PF02779 (1/2) Transketolase, pyrimidine binding domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01546 (1/2) Peptidase family M20/M25/M40 PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00501 (1/2) AMP-binding enzyme PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00155 (1/2) Aminotransferase class I and II PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family PF00107 (1/2) Zinc-binding dehydrogenase
GCF_000377965.1	258.00 +- 0.00	1	0	0	0.04 +- 0.02	1	8 PF17914 (1/1) HopA1 effector protein family PF13649 (1/1) Methyltransferase domain PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF01636 (1/1) Phosphotransferase enzyme family PF00675 (1/1) Insulinase (Peptidase family M16) PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_000725475.1	490.71 +- 218.20	3	3	1	0.01 +- 0.02	3	No common domains found
GCF_002797655.1	285.81 +- 215.38	4	0	0	0.05 +- 0.10	4	2 PF13416 (2/4) Bacterial extracellular solute-binding protein PF00528 (2/4) Binding-protein-dependent transport system inner membrane component
GCF_001509475.1	227.69 +- 209.03	3	1	0	0.03 +- 0.04	3	No common domains found
GCF_000203835.1	264.81 +- 0.00	1	1	1	0.04 +- 0.03	1	13 TIGR04451 (1/1) lantipeptide, SCO0268 family TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF12802 (1/1) MarR family PF12697 (1/1) Alpha/beta hydrolase family PF05147 (1/1) Lanthionine synthetase C-like protein PF04738 (1/1) Lantibiotic dehydratase, N terminus PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain PF02065 (1/1) Melibiase PF01547 (1/1) Bacterial extracellular solute-binding protein PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00480 (1/1) ROK family
GCF_000373305.1	637.54 +- 0.00	1	1	0	0.07 +- 0.22	1	19 TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR01356 (1/1) 3-phosphoshikimate 1-carboxyvinyltransferase TIGR01307 (1/1) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF18130 (1/1) ATP-grasp N-terminal domain PF13549 (1/1) ATP-grasp domain PF13535 (1/1) ATP-grasp domain PF13480 (1/1) Acetyltransferase (GNAT) domain PF13115 (1/1) YtkA-like PF04389 (1/1) Peptidase family M28 PF02627 (1/1) Carboxymuconolactone decarboxylase family PF01676 (1/1) Metalloenzyme superfamily PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00664 (1/1) ABC transporter transmembrane region PF00403 (1/1) Heavy-metal-associated domain PF00275 (1/1) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00155 (1/1) Aminotransferase class I and II PF00122 (1/1) E1-E2 ATPase PF00117 (1/1) Glutamine amidotransferase class-I PF00005 (1/1) ABC transporter
GCF_001746485.1	2157.83 +- 1185.02	2	2	1	0.03 +- 0.14	2	41 PF00005 (2/2) ABC transporter TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase TIGR00652 (1/2) diaminopimelate epimerase PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF14518 (1/2) Iron-containing redox enzyme PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal PF13649 (1/2) Methyltransferase domain PF13535 (1/2) ATP-grasp domain PF13458 (1/2) Periplasmic binding protein PF12730 (1/2) ABC-2 family transporter protein PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter PF10014 (1/2) 2OG-Fe dioxygenase PF08241 (1/2) Methyltransferase domain PF07859 (1/2) alpha/beta hydrolase fold PF07690 (1/2) Major Facilitator Superfamily PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH) PF05195 (1/2) Aminopeptidase P, N-terminal domain PF05147 (1/2) Lanthionine synthetase C-like protein PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily PF02653 (1/2) Branched-chain amino acid transport system / permease component PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family PF02153 (1/2) Prephenate dehydrogenase PF01678 (1/2) Diaminopimelate epimerase PF01575 (1/2) MaoC like domain PF01568 (1/2) Molydopterin dinucleotide binding domain PF01425 (1/2) Amidase PF01070 (1/2) FMN-dependent dehydrogenase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00892 (1/2) EamA-like transporter family PF00682 (1/2) HMGL-like PF00557 (1/2) Metallopeptidase family M24 PF00465 (1/2) Iron-containing alcohol dehydrogenase PF00384 (1/2) Molybdopterin oxidoreductase PF00296 (1/2) Luciferase-like monooxygenase PF00248 (1/2) Aldo/keto reductase family PF00202 (1/2) Aminotransferase class-III PF00155 (1/2) Aminotransferase class I and II PF00069 (1/2) Protein kinase domain
GCF_000720175.1	173.58 +- 93.70	4	2	0	0.03 +- 0.04	4	No common domains found
GCF_004217635.1	380.36 +- 133.98	3	1	0	0.02 +- 0.02	3	No common domains found
GCF_002803075.1	24.76 +- 0.00	1	0	0	0.08 +- 0.07	1	3 PF13602 (1/1) Zinc-binding dehydrogenase PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF01522 (1/1) Polysaccharide deacetylase
GCF_001482415.1	268.75 +- 168.50	3	1	2	0.04 +- 0.14	3	1 PF04055 (2/3) Radical SAM superfamily
GCF_001625365.1	258.31 +- 187.40	2	2	1	0.03 +- 0.04	2	13 TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1 PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF08877 (1/2) MepB protein PF08453 (1/2) Peptidase family M9 N-terminal PF07690 (1/2) Major Facilitator Superfamily PF04151 (1/2) Bacterial pre-peptidase C-terminal domain PF04055 (1/2) Radical SAM superfamily PF02310 (1/2) B12 binding domain PF01764 (1/2) Lipase (class 3) PF01752 (1/2) Collagenase PF00652 (1/2) Ricin-type beta-trefoil lectin domain PF00326 (1/2) Prolyl oligopeptidase family PF00067 (1/2) Cytochrome P450
GCF_001514285.1	294.16 +- 248.47	3	1	0	0.03 +- 0.05	3	2 PF00196 (2/3) Bacterial regulatory proteins, luxR family PF00004 (2/3) ATPase family associated with various cellular activities (AAA)
GCF_900110755.1	237.08 +- 134.92	3	1	1	0.08 +- 0.23	3	No common domains found
GCF_000280865.1	200.37 +- 37.42	2	2	1	0.06 +- 0.20	2	26 PF07690 (2/2) Major Facilitator Superfamily TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1 TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 TIGR00229 (1/2) PAS domain S-box protein TIGR00178 (1/2) isocitrate dehydrogenase, NADP-dependent PF13632 (1/2) Glycosyl transferase family group 2 PF13426 (1/2) PAS domain PF13419 (1/2) Haloacid dehalogenase-like hydrolase PF13191 (1/2) AAA ATPase domain PF12710 (1/2) haloacid dehalogenase-like hydrolase PF08448 (1/2) PAS fold PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF04321 (1/2) RmlD substrate binding domain PF04055 (1/2) Radical SAM superfamily PF03971 (1/2) Monomeric isocitrate dehydrogenase PF02310 (1/2) B12 binding domain PF01979 (1/2) Amidohydrolase family PF01590 (1/2) GAF domain PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00535 (1/2) Glycosyl transferase family 2 PF00480 (1/2) ROK family PF00459 (1/2) Inositol monophosphatase family PF00326 (1/2) Prolyl oligopeptidase family PF00294 (1/2) pfkB family carbohydrate kinase PF00202 (1/2) Aminotransferase class-III PF00196 (1/2) Bacterial regulatory proteins, luxR family
GCF_003984905.1	356.43 +- 276.61	2	0	0	0.04 +- 0.04	2	19 PF01425 (2/2) Amidase TIGR00928 (1/2) adenylosuccinate lyase TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family PF13673 (1/2) Acetyltransferase (GNAT) domain PF13460 (1/2) NAD(P)H-binding PF12800 (1/2) 4Fe-4S binding domain PF07690 (1/2) Major Facilitator Superfamily PF07681 (1/2) DoxX PF01814 (1/2) Hemerythrin HHE cation binding domain PF01494 (1/2) FAD binding domain PF01427 (1/2) D-ala-D-ala dipeptidase PF00561 (1/2) alpha/beta hydrolase fold PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00293 (1/2) NUDIX domain PF00206 (1/2) Lyase PF00120 (1/2) Glutamine synthetase, catalytic domain PF00072 (1/2) Response regulator receiver domain PF00069 (1/2) Protein kinase domain PF00005 (1/2) ABC transporter
GCF_001279655.1	1117.74 +- 1791.14	5	3	1	0.02 +- 0.01	5	No common domains found
GCF_001553475.1	169.85 +- 112.75	7	1	1	0.04 +- 0.04	7	No common domains found
GCF_003671685.1	516.00 +- 0.00	1	0	0	0.02 +- 0.01	1	5 PF13631 (1/1) Cytochrome b(N-terminal)/b6/petB PF07504 (1/1) Fungalysin/Thermolysin Propeptide Motif PF05630 (1/1) Necrosis inducing protein (NPP1) PF02868 (1/1) Thermolysin metallopeptidase, alpha-helical domain PF01447 (1/1) Thermolysin metallopeptidase, catalytic domain
GCF_000739105.1	184.29 +- 0.00	1	1	1	0.06 +- 0.03	1	13 TIGR04451 (1/1) lantipeptide, SCO0268 family TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF12802 (1/1) MarR family PF12697 (1/1) Alpha/beta hydrolase family PF05147 (1/1) Lanthionine synthetase C-like protein PF04738 (1/1) Lantibiotic dehydratase, N terminus PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain PF02065 (1/1) Melibiase PF01547 (1/1) Bacterial extracellular solute-binding protein PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00480 (1/1) ROK family
GCF_002300485.1	191.46 +- 93.23	2	1	0	0.06 +- 0.12	2	24 TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain TIGR01733 (1/2) amino acid adenylation domain TIGR00976 (1/2) hydrolase CocE/NonD family protein PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13460 (1/2) NAD(P)H-binding PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF07690 (1/2) Major Facilitator Superfamily PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18) PF00975 (1/2) Thioesterase domain PF00877 (1/2) NlpC/P60 family PF00698 (1/2) Acyl transferase domain PF00668 (1/2) Condensation domain PF00561 (1/2) alpha/beta hydrolase fold PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00296 (1/2) Luciferase-like monooxygenase PF00202 (1/2) Aminotransferase class-III PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00106 (1/2) short chain dehydrogenase
GCF_002920635.1	320.42 +- 0.00	1	0	0	0.03 +- 0.03	1	6 PF16925 (1/1) Tetracyclin repressor-like, C-terminal domain PF07883 (1/1) Cupin domain PF07690 (1/1) Major Facilitator Superfamily PF06779 (1/1) Uncharacterised MFS-type transporter YbfB PF01965 (1/1) DJ-1/PfpI family PF00440 (1/1) Bacterial regulatory proteins, tetR family
GCF_001445655.1	970.68 +- 552.63	5	2	0	0.01 +- 0.01	5	No common domains found
GCF_000365385.1	1526.50 +- 1483.50	2	2	1	0.03 +- 0.05	2	14 TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF13560 (1/2) Helix-turn-helix domain PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family PF07690 (1/2) Major Facilitator Superfamily PF04149 (1/2) Domain of unknown function (DUF397) PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF00905 (1/2) Penicillin binding protein transpeptidase domain PF00881 (1/2) Nitroreductase family PF00266 (1/2) Aminotransferase class-V PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00171 (1/2) Aldehyde dehydrogenase family
GCF_000718455.1	425.70 +- 0.00	1	0	0	0.02 +- 0.02	1	7 PF17914 (1/1) HopA1 effector protein family PF13649 (1/1) Methyltransferase domain PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF00675 (1/1) Insulinase (Peptidase family M16) PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_000715845.1	176.43 +- 46.43	2	2	1	0.02 +- 0.02	2	8 TIGR00229 (1/2) PAS domain S-box protein PF13471 (1/2) Transglutaminase-like superfamily PF08448 (1/2) PAS fold PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD) PF01979 (1/2) Amidohydrolase family PF01593 (1/2) Flavin containing amine oxidoreductase PF00733 (1/2) Asparagine synthase PF00196 (1/2) Bacterial regulatory proteins, luxR family
GCF_900104815.1	177.93 +- 150.06	3	1	1	0.03 +- 0.04	3	No common domains found
GCF_003626535.1	677.93 +- 507.14	3	0	2	0.01 +- 0.02	3	No common domains found
GCF_003814875.1	312.81 +- 169.79	5	1	0	0.02 +- 0.06	5	No common domains found
GCF_003323715.1	128.40 +- 0.00	1	0	0	0.06 +- 0.05	1	13 PF13377 (1/1) Periplasmic binding protein-like domain PF10022 (1/1) Uncharacterized protein conserved in bacteria (DUF2264) PF08124 (1/1) Polysaccharide lyase family 8, N terminal alpha-helical domain PF07228 (1/1) Stage II sporulation protein E (SpoIIE) PF07045 (1/1) Domain of unknown function (DUF1330) PF04030 (1/1) D-arabinono-1,4-lactone oxidase PF02884 (1/1) Polysaccharide lyase family 8, C-terminal beta-sandwich domain PF02826 (1/1) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PF02278 (1/1) Polysaccharide lyase family 8, super-sandwich domain PF01565 (1/1) FAD binding domain PF00722 (1/1) Glycosyl hydrolases family 16 PF00356 (1/1) Bacterial regulatory proteins, lacI family PF00067 (1/1) Cytochrome P450
GCF_000383595.1	3120.00 +- 0.00	1	0	0	0.01 +- 0.00	1	13 TIGR04245 (1/1) N-acyltransferase NodA TIGR04243 (1/1) chitooligosaccharide deacetylase NodB TIGR04242 (1/1) chitooligosaccharide synthase NodC TIGR01188 (1/1) daunorubicin resistance ABC transporter, ATP-binding protein PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain PF02474 (1/1) Nodulation protein A (NodA) PF01522 (1/1) Polysaccharide deacetylase PF01061 (1/1) ABC-2 type transporter PF00535 (1/1) Glycosyl transferase family 2 PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain PF00005 (1/1) ABC transporter
GCF_000722185.1	119.08 +- 41.08	2	0	1	0.07 +- 0.09	2	19 PF13581 (1/2) Histidine kinase-like ATPase domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13191 (1/2) AAA ATPase domain PF12802 (1/2) MarR family PF09346 (1/2) SMI1 / KNR4 family (SUKH-1) PF09339 (1/2) IclR helix-turn-helix domain PF07883 (1/2) Cupin domain PF07690 (1/2) Major Facilitator Superfamily PF05147 (1/2) Lanthionine synthetase C-like protein PF04978 (1/2) Protein of unknown function (DUF664) PF04909 (1/2) Amidohydrolase PF04199 (1/2) Putative cyclase PF01614 (1/2) Bacterial transcriptional regulator PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family PF01494 (1/2) FAD binding domain PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00561 (1/2) alpha/beta hydrolase fold PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00005 (1/2) ABC transporter
GCF_000719435.1	258.00 +- 0.00	1	0	0	0.01 +- 0.00	1	2 PF01757 (1/1) Acyltransferase family PF00248 (1/1) Aldo/keto reductase family
GCF_001484625.1	618.38 +- 0.00	1	0	1	0.03 +- 0.03	1	11 TIGR04469 (1/1) CGA synthase-related protein TIGR04468 (1/1) arginine 2,3-aminomutase TIGR04467 (1/1) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase TIGR04466 (1/1) cytosylglucuronate decarboxylase PF18603 (1/1) L-amino acid ligase C-terminal domain 2 PF08241 (1/1) Methyltransferase domain PF07690 (1/1) Major Facilitator Superfamily PF05014 (1/1) Nucleoside 2-deoxyribosyltransferase PF04055 (1/1) Radical SAM superfamily PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family PF00296 (1/1) Luciferase-like monooxygenase
GCF_001553455.1	263.15 +- 138.65	5	0	0	0.03 +- 0.05	5	No common domains found
GCF_002188345.1	304.39 +- 0.00	1	1	0	0.04 +- 0.04	1	6 TIGR03892 (1/1) thiazolylpeptide-type bacteriocin precursor PF13193 (1/1) AMP-binding enzyme C-terminal domain PF01959 (1/1) 3-dehydroquinate synthase II PF01791 (1/1) DeoC/LacD family aldolase PF01494 (1/1) FAD binding domain PF00501 (1/1) AMP-binding enzyme
GCF_002154415.1	1231.32 +- 1108.68	2	1	1	0.03 +- 0.05	2	15 TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1 TIGR00745 (1/2) 2-dehydropantoate 2-reductase PF09084 (1/2) NMT1/THI5 like PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal PF07690 (1/2) Major Facilitator Superfamily PF04055 (1/2) Radical SAM superfamily PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF02597 (1/2) ThiS family PF02558 (1/2) Ketopantoate reductase PanE/ApbA PF02310 (1/2) B12 binding domain PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00155 (1/2) Aminotransferase class I and II PF00106 (1/2) short chain dehydrogenase PF00067 (1/2) Cytochrome P450 PF00005 (1/2) ABC transporter
GCF_000424825.1	1161.00 +- 0.00	1	1	0	0.01 +- 0.00	1	9 PF13193 (1/1) AMP-binding enzyme C-terminal domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07690 (1/1) Major Facilitator Superfamily PF03704 (1/1) Bacterial transcriptional activator domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00486 (1/1) Transcriptional regulatory protein, C terminal PF00196 (1/1) Bacterial regulatory proteins, luxR family
GCF_003949695.1	51.60 +- 0.00	1	0	0	0.04 +- 0.03	1	2 PF01048 (1/1) Phosphorylase superfamily PF00293 (1/1) NUDIX domain
GCF_002551055.1	22.61 +- 0.00	1	0	0	0.09 +- 0.08	1	2 PF13673 (1/1) Acetyltransferase (GNAT) domain PF01872 (1/1) RibD C-terminal domain
GCF_001294335.1	242.77 +- 136.40	2	2	1	0.03 +- 0.02	2	13 PF00005 (2/2) ABC transporter TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain TIGR03731 (1/2) lantibiotic, gallidermin/nisin family TIGR02276 (1/2) 40-residue YVTN family beta-propeller repeat PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term PF10282 (1/2) Lactonase, 7-bladed beta-propeller PF05147 (1/2) Lanthionine synthetase C-like protein PF04738 (1/2) Lantibiotic dehydratase, N terminus PF04072 (1/2) Leucine carboxyl methyltransferase PF02052 (1/2) Gallidermin PF01061 (1/2) ABC-2 type transporter PF00664 (1/2) ABC transporter transmembrane region PF00069 (1/2) Protein kinase domain
GCF_003268965.1	188.43 +- 122.64	3	1	1	0.04 +- 0.08	3	1 PF00440 (2/3) Bacterial regulatory proteins, tetR family
GCF_003665435.1	390.00 +- 0.00	1	0	0	0.01 +- 0.00	1	7 TIGR03930 (1/1) WXG100 family type VII secretion target TIGR03920 (1/1) type VII secretion integral membrane protein EccD TIGR03919 (1/1) type VII secretion protein EccB PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD PF06013 (1/1) Proteins of 100 residues with WXG PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B PF02575 (1/1) YbaB/EbfC DNA-binding family
GCF_003698085.1	516.00 +- 0.00	1	1	0	0.01 +- 0.00	1	8 PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF02780 (1/1) Transketolase, C-terminal domain PF02779 (1/1) Transketolase, pyrimidine binding domain PF00676 (1/1) Dehydrogenase E1 component PF00550 (1/1) Phosphopantetheine attachment site PF00364 (1/1) Biotin-requiring enzyme PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
GCF_002910875.1	448.42 +- 177.41	3	3	2	0.06 +- 0.07	3	3 PF00005 (3/3) ABC transporter PF05147 (2/3) Lanthionine synthetase C-like protein PF00664 (2/3) ABC transporter transmembrane region
GCF_002188365.1	660.18 +- 629.82	2	1	0	0.02 +- 0.02	2	12 TIGR02227 (1/2) signal peptidase I PF17874 (1/2) MalT-like TPR region PF10502 (1/2) Signal peptidase, peptidase S26 PF07291 (1/2) Methylamine utilisation protein MauE PF03992 (1/2) Antibiotic biosynthesis monooxygenase PF03704 (1/2) Bacterial transcriptional activator domain PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase PF00931 (1/2) NB-ARC domain PF00899 (1/2) ThiF family PF00717 (1/2) Peptidase S24-like PF00486 (1/2) Transcriptional regulatory protein, C terminal PF00005 (1/2) ABC transporter
GCF_003634225.1	794.07 +- 758.65	5	2	1	0.04 +- 0.10	5	1 PF00005 (3/5) ABC transporter
GCF_003725745.1	119.08 +- 0.00	1	0	0	0.03 +- 0.04	1	6 PF13411 (1/1) MerR HTH family regulatory protein PF07690 (1/1) Major Facilitator Superfamily PF04909 (1/1) Amidohydrolase PF02945 (1/1) Recombination endonuclease VII PF01794 (1/1) Ferric reductase like transmembrane component PF00175 (1/1) Oxidoreductase NAD-binding domain
GCF_002119195.1	258.03 +- 169.34	4	2	0	0.04 +- 0.10	4	1 PF01494 (2/4) FAD binding domain
GCF_002300355.1	541.67 +- 542.10	3	1	1	0.02 +- 0.02	3	No common domains found
GCF_001418575.1	270.45 +- 55.45	2	0	0	0.04 +- 0.04	2	13 TIGR03086 (1/2) TIGR03086 family protein TIGR01891 (1/2) amidohydrolase PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain PF09084 (1/2) NMT1/THI5 like PF07920 (1/2) Protein of unknown function (DUF1684) PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily PF01546 (1/2) Peptidase family M20/M25/M40 PF00581 (1/2) Rhodanese-like domain PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00376 (1/2) MerR family regulatory protein PF00296 (1/2) Luciferase-like monooxygenase PF00005 (1/2) ABC transporter
GCF_002551295.1	294.86 +- 0.00	1	0	0	0.01 +- 0.01	1	7 TIGR03920 (1/1) type VII secretion integral membrane protein EccD TIGR03919 (1/1) type VII secretion protein EccB PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD PF07179 (1/1) SseB protein N-terminal domain PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B PF04488 (1/1) Glycosyltransferase sugar-binding region containing DXD motif PF02575 (1/1) YbaB/EbfC DNA-binding family
GCF_001865255.1	1040.00 +- 0.00	1	0	1	0.01 +- 0.00	1	12 TIGR01509 (1/1) HAD hydrolase, family IA, variant 3 PF13489 (1/1) Methyltransferase domain PF13419 (1/1) Haloacid dehalogenase-like hydrolase PF13394 (1/1) 4Fe-4S single cluster domain PF04055 (1/1) Radical SAM superfamily PF02223 (1/1) Thymidylate kinase PF01259 (1/1) SAICAR synthetase PF01242 (1/1) 6-pyruvoyl tetrahydropterin synthase PF01227 (1/1) GTP cyclohydrolase I PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family PF00929 (1/1) Exonuclease PF00156 (1/1) Phosphoribosyl transferase domain
GCF_002551065.1	164.18 +- 0.00	1	0	0	0.04 +- 0.02	1	5 PF17914 (1/1) HopA1 effector protein family PF13649 (1/1) Methyltransferase domain PF05193 (1/1) Peptidase M16 inactive domain PF02441 (1/1) Flavoprotein PF00675 (1/1) Insulinase (Peptidase family M16)
GCF_000719425.1	195.00 +- 65.00	2	0	0	0.01 +- 0.01	2	3 PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase PF03130 (1/2) PBS lyase HEAT-like repeat PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
GCF_001279105.1	57.78 +- 0.00	1	1	1	0.05 +- 0.00	1	3 PF13471 (1/1) Transglutaminase-like superfamily PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD) PF00733 (1/1) Asparagine synthase
GCF_002727115.1	516.00 +- 0.00	1	1	1	0.01 +- 0.00	1	7 TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain TIGR03558 (1/1) luciferase family oxidoreductase, group 1 PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF05147 (1/1) Lanthionine synthetase C-like protein PF04738 (1/1) Lantibiotic dehydratase, N terminus PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_003550115.1	704.49 +- 736.25	3	1	1	0.03 +- 0.06	3	1 PF00005 (2/3) ABC transporter
GCF_002188355.1	194.62 +- 33.37	2	0	0	0.07 +- 0.07	2	29 TIGR00745 (1/2) 2-dehydropantoate 2-reductase TIGR00055 (1/2) di-trans,poly-cis-decaprenylcistransferase PF14310 (1/2) Fibronectin type III-like domain PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF13529 (1/2) Peptidase_C39 like family PF13515 (1/2) Fusaric acid resistance protein-like PF13404 (1/2) AsnC-type helix-turn-helix domain PF13377 (1/2) Periplasmic binding protein-like domain PF13202 (1/2) EF hand PF12833 (1/2) Helix-turn-helix domain PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236) PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal PF08386 (1/2) TAP-like protein PF07690 (1/2) Major Facilitator Superfamily PF02558 (1/2) Ketopantoate reductase PanE/ApbA PF01965 (1/2) DJ-1/PfpI family PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain PF01547 (1/2) Bacterial extracellular solute-binding protein PF01546 (1/2) Peptidase family M20/M25/M40 PF01522 (1/2) Polysaccharide deacetylase PF01471 (1/2) Putative peptidoglycan binding domain PF01255 (1/2) Putative undecaprenyl diphosphate synthase PF01037 (1/2) Lrp/AsnC ligand binding domain PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain PF00561 (1/2) alpha/beta hydrolase fold PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00356 (1/2) Bacterial regulatory proteins, lacI family PF00150 (1/2) Cellulase (glycosyl hydrolase family 5) PF00083 (1/2) Sugar (and other) transporter
GCF_001553435.1	268.35 +- 119.41	4	0	0	0.02 +- 0.01	4	1 PF07690 (3/4) Major Facilitator Superfamily
GCF_001279495.1	618.44 +- 542.56	2	0	1	0.03 +- 0.05	2	29 TIGR02493 (1/2) pyruvate formate-lyase 1-activating enzyme TIGR01828 (1/2) pyruvate, phosphate dikinase TIGR01426 (1/2) glycosyltransferase, MGT family TIGR01255 (1/2) formate acetyltransferase PF17914 (1/2) HopA1 effector protein family PF14325 (1/2) Domain of unknown function (DUF4383) PF13692 (1/2) Glycosyl transferases group 1 PF13601 (1/2) Winged helix DNA-binding domain PF13411 (1/2) MerR HTH family regulatory protein PF12698 (1/2) ABC-2 family transporter protein PF05719 (1/2) Golgi phosphoprotein 3 (GPP34) PF05193 (1/2) Peptidase M16 inactive domain PF04055 (1/2) Radical SAM superfamily PF02901 (1/2) Pyruvate formate lyase-like PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain PF02607 (1/2) B12 binding domain PF02441 (1/2) Flavoprotein PF01636 (1/2) Phosphotransferase enzyme family PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain PF01228 (1/2) Glycine radical PF00891 (1/2) O-methyltransferase domain PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00582 (1/2) Universal stress protein family PF00391 (1/2) PEP-utilising enzyme, mobile domain PF00296 (1/2) Luciferase-like monooxygenase PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase PF00106 (1/2) short chain dehydrogenase PF00005 (1/2) ABC transporter
GCF_004212445.1	246.07 +- 192.36	5	2	3	0.04 +- 0.13	5	2 PF07690 (3/5) Major Facilitator Superfamily PF04055 (3/5) Radical SAM superfamily
GCF_000719355.1	1043.58 +- 742.58	2	1	1	0.02 +- 0.02	2	14 TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM PF17914 (1/2) HopA1 effector protein family PF13649 (1/2) Methyltransferase domain PF13575 (1/2) Domain of unknown function (DUF4135) PF12679 (1/2) ABC-2 family transporter protein PF05193 (1/2) Peptidase M16 inactive domain PF05147 (1/2) Lanthionine synthetase C-like protein PF04978 (1/2) Protein of unknown function (DUF664) PF03412 (1/2) Peptidase C39 family PF02441 (1/2) Flavoprotein PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00005 (1/2) ABC transporter
GCF_002754515.1	661.82 +- 378.18	2	0	1	0.06 +- 0.08	2	18 TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component TIGR01234 (1/2) ribulokinase PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like PF14016 (1/2) Protein of unknown function (DUF4232) PF11762 (1/2) L-arabinose isomerase C-terminal domain PF07690 (1/2) Major Facilitator Superfamily PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain PF05193 (1/2) Peptidase M16 inactive domain PF03358 (1/2) NADPH-dependent FMN reductase PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02610 (1/2) L-arabinose isomerase PF02517 (1/2) CPBP intramembrane metalloprotease PF01547 (1/2) Bacterial extracellular solute-binding protein PF00675 (1/2) Insulinase (Peptidase family M16) PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
GCF_001419765.1	244.42 +- 0.00	1	0	0	0.02 +- 0.01	1	9 TIGR01296 (1/1) aspartate-semialdehyde dehydrogenase PF12833 (1/1) Helix-turn-helix domain PF02774 (1/1) Semialdehyde dehydrogenase, dimerisation domain PF01965 (1/1) DJ-1/PfpI family PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain PF00696 (1/1) Amino acid kinase family PF00465 (1/1) Iron-containing alcohol dehydrogenase PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00171 (1/1) Aldehyde dehydrogenase family
GCF_001279935.1	856.51 +- 814.91	2	1	0	0.02 +- 0.03	2	20 TIGR01426 (1/2) glycosyltransferase, MGT family PF18616 (1/2) CDI immunity proteins PF18029 (1/2) Glyoxalase-like domain PF17914 (1/2) HopA1 effector protein family PF13692 (1/2) Glycosyl transferases group 1 PF13649 (1/2) Methyltransferase domain PF13601 (1/2) Winged helix DNA-binding domain PF12698 (1/2) ABC-2 family transporter protein PF06276 (1/2) Ferric iron reductase FhuF-like transporter PF05719 (1/2) Golgi phosphoprotein 3 (GPP34) PF05193 (1/2) Peptidase M16 inactive domain PF04183 (1/2) IucA / IucC family PF02441 (1/2) Flavoprotein PF01636 (1/2) Phosphotransferase enzyme family PF00891 (1/2) O-methyltransferase domain PF00675 (1/2) Insulinase (Peptidase family M16) PF00664 (1/2) ABC transporter transmembrane region PF00296 (1/2) Luciferase-like monooxygenase PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase PF00005 (1/2) ABC transporter
GCF_002289305.1	690.33 +- 625.33	2	1	0	0.04 +- 0.06	2	36 TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family TIGR01746 (1/2) thioester reductase domain TIGR01733 (1/2) amino acid adenylation domain TIGR01525 (1/2) heavy metal translocating P-type ATPase TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096) PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12770 (1/2) CHAT domain PF10862 (1/2) FcoT-like thioesterase domain PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF08281 (1/2) Sigma-70, region 4 PF07993 (1/2) Male sterility protein PF07690 (1/2) Major Facilitator Superfamily PF07510 (1/2) Protein of unknown function (DUF1524) PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase PF04542 (1/2) Sigma-70 region 2 PF04314 (1/2) Copper chaperone PCu(A)C PF03929 (1/2) PepSY-associated TM region PF03235 (1/2) Protein of unknown function DUF262 PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/2) DJ-1/PfpI family PF01794 (1/2) Ferric reductase like transmembrane component PF01636 (1/2) Phosphotransferase enzyme family PF01609 (1/2) Transposase DDE domain PF01497 (1/2) Periplasmic binding protein PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain PF01032 (1/2) FecCD transport family PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00403 (1/2) Heavy-metal-associated domain PF00122 (1/2) E1-E2 ATPase PF00005 (1/2) ABC transporter
GCF_900105275.1	338.45 +- 181.55	2	0	1	0.03 +- 0.04	2	17 TIGR04267 (1/2) HEXXH motif domain TIGR01187 (1/2) polyamine ABC transporter, ATP-binding protein TIGR00702 (1/2) YcaO-type kinase domain PF18029 (1/2) Glyoxalase-like domain PF13489 (1/2) Methyltransferase domain PF13416 (1/2) Bacterial extracellular solute-binding protein PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase PF08402 (1/2) TOBE domain PF07812 (1/2) TfuA-like protein PF07690 (1/2) Major Facilitator Superfamily PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01593 (1/2) Flavin containing amine oxidoreductase PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain) PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00355 (1/2) Rieske [2Fe-2S] domain PF00171 (1/2) Aldehyde dehydrogenase family PF00005 (1/2) ABC transporter
GCF_003947575.1	227.50 +- 315.57	4	1	2	0.03 +- 0.03	4	1 PF00733 (2/4) Asparagine synthase
GCF_003259355.1	190.87 +- 90.07	3	1	0	0.06 +- 0.14	3	2 PF07729 (2/3) FCD domain PF00392 (2/3) Bacterial regulatory proteins, gntR family
GCF_000720605.1	131.15 +- 44.17	3	1	1	0.03 +- 0.04	3	No common domains found
GCF_004125315.1	230.24 +- 94.74	4	2	0	0.05 +- 0.10	4	1 PF07690 (2/4) Major Facilitator Superfamily
GCF_001270495.1	500.90 +- 402.10	2	1	0	0.04 +- 0.06	2	31 TIGR03425 (1/2) urea carboxylase-associated protein 2 TIGR03424 (1/2) urea carboxylase-associated protein 1 TIGR02712 (1/2) urea carboxylase TIGR01930 (1/2) acetyl-CoA C-acyltransferase TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF13535 (1/2) ATP-grasp domain PF13520 (1/2) Amino acid permease PF13419 (1/2) Haloacid dehalogenase-like hydrolase PF13394 (1/2) 4Fe-4S single cluster domain PF09347 (1/2) Domain of unknown function (DUF1989) PF07690 (1/2) Major Facilitator Superfamily PF06508 (1/2) Queuosine biosynthesis protein QueC PF06368 (1/2) Methylaspartate mutase E chain (MutE) PF02803 (1/2) Thiolase, C-terminal domain PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain PF02785 (1/2) Biotin carboxylase C-terminal domain PF02682 (1/2) Carboxyltransferase domain, subdomain C and D PF02626 (1/2) Carboxyltransferase domain, subdomain A and B PF02310 (1/2) B12 binding domain PF01425 (1/2) Amidase PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase PF01227 (1/2) GTP cyclohydrolase I PF00668 (1/2) Condensation domain PF00501 (1/2) AMP-binding enzyme PF00487 (1/2) Fatty acid desaturase PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00364 (1/2) Biotin-requiring enzyme PF00289 (1/2) Biotin carboxylase, N-terminal domain PF00108 (1/2) Thiolase, N-terminal domain
GCF_002910825.1	331.96 +- 0.00	1	0	0	0.04 +- 0.01	1	13 TIGR03561 (1/1) peroxiredoxin, Ohr subfamily PF13649 (1/1) Methyltransferase domain PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF09339 (1/1) IclR helix-turn-helix domain PF09084 (1/1) NMT1/THI5 like PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase PF02566 (1/1) OsmC-like protein PF01614 (1/1) Bacterial transcriptional regulator PF01546 (1/1) Peptidase family M20/M25/M40 PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family PF00561 (1/1) alpha/beta hydrolase fold PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00005 (1/1) ABC transporter
GCF_000716445.1	752.38 +- 183.71	4	2	1	0.02 +- 0.01	4	3 PF13378 (2/4) Enolase C-terminal domain-like PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF00005 (2/4) ABC transporter
GCF_000367365.1	188.34 +- 118.24	3	0	0	0.04 +- 0.10	3	No common domains found
GCF_001184025.1	120.12 +- 80.47	3	1	1	0.06 +- 0.16	3	No common domains found
GCF_004122735.1	646.47 +- 30.78	2	2	0	0.01 +- 0.01	2	22 TIGR01509 (1/2) HAD hydrolase, family IA, variant 3 TIGR01392 (1/2) homoserine O-acetyltransferase TIGR01326 (1/2) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase PF13419 (1/2) Haloacid dehalogenase-like hydrolase PF13191 (1/2) AAA ATPase domain PF12710 (1/2) haloacid dehalogenase-like hydrolase PF07722 (1/2) Peptidase C26 PF07690 (1/2) Major Facilitator Superfamily PF04321 (1/2) RmlD substrate binding domain PF04185 (1/2) Phosphoesterase family PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain PF01979 (1/2) Amidohydrolase family PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme PF00892 (1/2) EamA-like transporter family PF00561 (1/2) alpha/beta hydrolase fold PF00535 (1/2) Glycosyl transferase family 2 PF00487 (1/2) Fatty acid desaturase PF00480 (1/2) ROK family PF00459 (1/2) Inositol monophosphatase family PF00294 (1/2) pfkB family carbohydrate kinase PF00202 (1/2) Aminotransferase class-III PF00196 (1/2) Bacterial regulatory proteins, luxR family
GCF_001514305.1	258.00 +- 0.00	1	1	0	0.02 +- 0.02	1	5 PF13523 (1/1) Acetyltransferase (GNAT) domain PF13193 (1/1) AMP-binding enzyme C-terminal domain PF00561 (1/1) alpha/beta hydrolase fold PF00501 (1/1) AMP-binding enzyme PF00106 (1/1) short chain dehydrogenase
GCF_000302615.1	761.41 +- 591.24	3	2	1	0.02 +- 0.01	3	No common domains found
GCF_003671715.1	520.00 +- 0.00	1	0	0	0.02 +- 0.01	1	4 PF13649 (1/1) Methyltransferase domain PF12698 (1/1) ABC-2 family transporter protein PF02441 (1/1) Flavoprotein PF00005 (1/1) ABC transporter
GCF_000514995.1	577.33 +- 196.67	2	1	0	0.03 +- 0.02	2	28 TIGR01733 (1/2) amino acid adenylation domain TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain PF17645 (1/2) Arylmalonate decarboxylase PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF13535 (1/2) ATP-grasp domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF12706 (1/2) Beta-lactamase superfamily domain PF09339 (1/2) IclR helix-turn-helix domain PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region PF05685 (1/2) Putative restriction endonuclease PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02426 (1/2) Muconolactone delta-isomerase PF01636 (1/2) Phosphotransferase enzyme family PF01614 (1/2) Bacterial transcriptional regulator PF01593 (1/2) Flavin containing amine oxidoreductase PF01244 (1/2) Membrane dipeptidase (Peptidase family M19) PF00975 (1/2) Thioesterase domain PF00698 (1/2) Acyl transferase domain PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00501 (1/2) AMP-binding enzyme PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00326 (1/2) Prolyl oligopeptidase family PF00171 (1/2) Aldehyde dehydrogenase family PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (1/2) ABC transporter
GCF_001905345.1	497.47 +- 317.11	6	1	0	0.02 +- 0.03	6	No common domains found
GCF_002803175.1	2064.71 +- 0.00	1	1	1	0.01 +- 0.01	1	9 TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM PF14867 (1/1) Lantibiotic alpha PF13575 (1/1) Domain of unknown function (DUF4135) PF12730 (1/1) ABC-2 family transporter protein PF05147 (1/1) Lanthionine synthetase C-like protein PF03703 (1/1) Bacterial PH domain PF03412 (1/1) Peptidase C39 family PF00664 (1/1) ABC transporter transmembrane region PF00005 (1/1) ABC transporter
GCF_001190165.1	96.18 +- 0.00	1	1	0	0.08 +- 0.19	1	25 TIGR01762 (1/1) chlorinating enzyme TIGR01733 (1/1) amino acid adenylation domain TIGR01509 (1/1) HAD hydrolase, family IA, variant 3 TIGR01444 (1/1) methyltransferase, FkbM family TIGR00843 (1/1) benzoate transporter PF16990 (1/1) Carbohydrate binding module (family 35) PF13560 (1/1) Helix-turn-helix domain PF13535 (1/1) ATP-grasp domain PF13454 (1/1) FAD-NAD(P)-binding PF13419 (1/1) Haloacid dehalogenase-like hydrolase PF13193 (1/1) AMP-binding enzyme C-terminal domain PF07691 (1/1) PA14 domain PF06439 (1/1) Domain of Unknown Function (DUF1080) PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH) PF05050 (1/1) Methyltransferase FkbM domain PF04149 (1/1) Domain of unknown function (DUF397) PF03594 (1/1) Benzoate membrane transport protein PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain PF01116 (1/1) Fructose-bisphosphate aldolase class-II PF00975 (1/1) Thioesterase domain PF00892 (1/1) EamA-like transporter family PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
GCF_001885705.1	162.58 +- 127.13	2	0	0	0.06 +- 0.10	2	21 PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF13671 (1/2) AAA domain PF13535 (1/2) ATP-grasp domain PF12911 (1/2) N-terminal TM domain of oligopeptide transport permease C PF12833 (1/2) Helix-turn-helix domain PF11706 (1/2) CGNR zinc finger PF08240 (1/2) Alcohol dehydrogenase GroES-like domain PF07690 (1/2) Major Facilitator Superfamily PF07336 (1/2) Putative stress-induced transcription regulator PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF01965 (1/2) DJ-1/PfpI family PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF00696 (1/2) Amino acid kinase family PF00561 (1/2) alpha/beta hydrolase fold PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00465 (1/2) Iron-containing alcohol dehydrogenase PF00196 (1/2) Bacterial regulatory proteins, luxR family PF00171 (1/2) Aldehyde dehydrogenase family PF00107 (1/2) Zinc-binding dehydrogenase
GCF_003977875.1	354.75 +- 161.25	2	0	1	0.01 +- 0.01	2	13 TIGR01840 (1/2) esterase, PHB depolymerase family TIGR00702 (1/2) YcaO-type kinase domain TIGR00666 (1/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase PF18029 (1/2) Glyoxalase-like domain PF14016 (1/2) Protein of unknown function (DUF4232) PF13489 (1/2) Methyltransferase domain PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase PF10503 (1/2) Esterase PHB depolymerase PF07812 (1/2) TfuA-like protein PF07690 (1/2) Major Facilitator Superfamily PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02113 (1/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family PF00067 (1/2) Cytochrome P450
GCF_002846355.1	47.12 +- 16.48	5	3	1	0.06 +- 0.04	5	No common domains found
GCF_003977855.1	150.94 +- 0.00	1	0	0	0.01 +- 0.00	1	7 TIGR00398 (1/1) methionine--tRNA ligase TIGR00010 (1/1) hydrolase, TatD family PF09334 (1/1) tRNA synthetases class I (M) PF07501 (1/1) G5 domain PF06737 (1/1) Transglycosylase-like domain PF03990 (1/1) G5-linked-Ubiquitin-like domain PF01026 (1/1) TatD related DNase
GCF_001753425.1	196.30 +- 0.00	1	1	1	0.07 +- 0.09	1	12 TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/1) SagB-type dehydrogenase domain TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF04738 (1/1) Lantibiotic dehydratase, N terminus PF03704 (1/1) Bacterial transcriptional activator domain PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF01061 (1/1) ABC-2 type transporter PF00931 (1/1) NB-ARC domain PF00881 (1/1) Nitroreductase family PF00486 (1/1) Transcriptional regulatory protein, C terminal PF00005 (1/1) ABC transporter
GCF_001905485.1	478.70 +- 415.73	5	2	1	0.04 +- 0.04	5	No common domains found
GCF_001013905.1	1677.00 +- 0.00	1	0	0	0.01 +- 0.00	1	8 PF17914 (1/1) HopA1 effector protein family PF02441 (1/1) Flavoprotein PF01061 (1/1) ABC-2 type transporter PF00891 (1/1) O-methyltransferase domain PF00675 (1/1) Insulinase (Peptidase family M16) PF00664 (1/1) ABC transporter transmembrane region PF00296 (1/1) Luciferase-like monooxygenase PF00005 (1/1) ABC transporter
GCF_004124325.1	1418.18 +- 0.00	1	0	0	0.01 +- 0.00	1	8 PF13738 (1/1) Pyridine nucleotide-disulphide oxidoreductase PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF07722 (1/1) Peptidase C26 PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH) PF00202 (1/1) Aminotransferase class-III PF00171 (1/1) Aldehyde dehydrogenase family PF00120 (1/1) Glutamine synthetase, catalytic domain PF00107 (1/1) Zinc-binding dehydrogenase
GCF_003386245.1	1182.19 +- 402.19	2	1	1	0.04 +- 0.15	2	41 TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03856 (1/2) probable F420-dependent oxidoreductase, MSMEG_2906 family TIGR03605 (1/2) SagB-type dehydrogenase domain TIGR01733 (1/2) amino acid adenylation domain TIGR01686 (1/2) FkbH domain TIGR00976 (1/2) hydrolase CocE/NonD family protein PF18563 (1/2) TubC N-terminal docking domain PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF16058 (1/2) Mucin-like PF14765 (1/2) Polyketide synthase dehydratase PF13602 (1/2) Zinc-binding dehydrogenase PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08659 (1/2) KR domain PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PF08240 (1/2) Alcohol dehydrogenase GroES-like domain PF07690 (1/2) Major Facilitator Superfamily PF03972 (1/2) MmgE/PrpD family PF03621 (1/2) MbtH-like protein PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02195 (1/2) ParB-like nuclease domain PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family) PF01266 (1/2) FAD dependent oxidoreductase PF00975 (1/2) Thioesterase domain PF00881 (1/2) Nitroreductase family PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain PF00698 (1/2) Acyl transferase domain PF00675 (1/2) Insulinase (Peptidase family M16) PF00668 (1/2) Condensation domain PF00664 (1/2) ABC transporter transmembrane region PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00296 (1/2) Luciferase-like monooxygenase PF00291 (1/2) Pyridoxal-phosphate dependent enzyme PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00005 (1/2) ABC transporter
GCF_900103455.1	394.48 +- 0.00	1	1	0	0.03 +- 0.03	1	9 PF13416 (1/1) Bacterial extracellular solute-binding protein PF13377 (1/1) Periplasmic binding protein-like domain PF11941 (1/1) Domain of unknown function (DUF3459) PF03777 (1/1) ChpA-C PF00583 (1/1) Acetyltransferase (GNAT) family PF00528 (1/1) Binding-protein-dependent transport system inner membrane component PF00356 (1/1) Bacterial regulatory proteins, lacI family PF00293 (1/1) NUDIX domain PF00128 (1/1) Alpha amylase, catalytic domain
GCF_001953885.1	397.17 +- 301.03	4	0	0	0.04 +- 0.14	4	No common domains found
GCF_900207595.1	79.68 +- 49.32	2	0	0	0.09 +- 0.12	2	15 PF00440 (2/2) Bacterial regulatory proteins, tetR family TIGR00229 (1/2) PAS domain S-box protein PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase PF12680 (1/2) SnoaL-like domain PF08448 (1/2) PAS fold PF08220 (1/2) DeoR-like helix-turn-helix domain PF07228 (1/2) Stage II sporulation protein E (SpoIIE) PF07045 (1/2) Domain of unknown function (DUF1330) PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain PF01738 (1/2) Dienelactone hydrolase family PF01590 (1/2) GAF domain PF00664 (1/2) ABC transporter transmembrane region PF00455 (1/2) DeoR C terminal sensor domain PF00069 (1/2) Protein kinase domain PF00005 (1/2) ABC transporter
GCF_001729485.1	651.76 +- 359.14	3	2	2	0.02 +- 0.03	3	1 PF00005 (2/3) ABC transporter
GCF_900091895.1	241.43 +- 0.00	1	0	0	0.05 +- 0.10	1	15 TIGR01182 (1/1) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase PF14315 (1/1) Domain of unknown function (DUF4380) PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13407 (1/1) Periplasmic binding protein domain PF13378 (1/1) Enolase C-terminal domain-like PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region PF08240 (1/1) Alcohol dehydrogenase GroES-like domain PF07729 (1/1) FCD domain PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PF02653 (1/1) Branched-chain amino acid transport system / permease component PF01081 (1/1) KDPG and KHG aldolase PF00392 (1/1) Bacterial regulatory proteins, gntR family PF00294 (1/1) pfkB family carbohydrate kinase PF00107 (1/1) Zinc-binding dehydrogenase PF00005 (1/1) ABC transporter
GCF_003344905.1	1765.69 +- 1717.31	2	0	0	0.01 +- 0.02	2	28 TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain PF12680 (1/2) SnoaL-like domain PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region PF05199 (1/2) GMC oxidoreductase PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase PF02571 (1/2) Precorrin-6x reductase CbiJ/CobK PF01799 (1/2) [2Fe-2S] binding domain PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain PF01266 (1/2) FAD dependent oxidoreductase PF01244 (1/2) Membrane dipeptidase (Peptidase family M19) PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region PF00732 (1/2) GMC oxidoreductase PF00561 (1/2) alpha/beta hydrolase fold PF00544 (1/2) Pectate lyase PF00528 (1/2) Binding-protein-dependent transport system inner membrane component PF00501 (1/2) AMP-binding enzyme PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle PF00450 (1/2) Serine carboxypeptidase PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF00378 (1/2) Enoyl-CoA hydratase/isomerase PF00326 (1/2) Prolyl oligopeptidase family PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase PF00171 (1/2) Aldehyde dehydrogenase family PF00005 (1/2) ABC transporter
GCF_000721605.1	681.06 +- 0.00	1	0	1	0.05 +- 0.03	1	20 TIGR04364 (1/1) methyltransferase, FxLD system TIGR04363 (1/1) FxLD family lantipeptide TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term PF13649 (1/1) Methyltransferase domain PF05331 (1/1) Protein of unknown function (DUF742) PF05147 (1/1) Lanthionine synthetase C-like protein PF04738 (1/1) Lantibiotic dehydratase, N terminus PF03259 (1/1) Roadblock/LC7 domain PF03029 (1/1) Conserved hypothetical ATP binding protein PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain PF01590 (1/1) GAF domain PF01427 (1/1) D-ala-D-ala dipeptidase PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PF00723 (1/1) Glycosyl hydrolases family 15 PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain PF00293 (1/1) NUDIX domain PF00196 (1/1) Bacterial regulatory proteins, luxR family PF00005 (1/1) ABC transporter
GCF_000718015.1	436.62 +- 0.00	1	0	0	0.01 +- 0.00	1	10 TIGR03930 (1/1) WXG100 family type VII secretion target TIGR03920 (1/1) type VII secretion integral membrane protein EccD TIGR03919 (1/1) type VII secretion protein EccB PF17866 (1/1) AAA lid domain PF13229 (1/1) Right handed beta helix region PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD PF06013 (1/1) Proteins of 100 residues with WXG PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B PF02575 (1/1) YbaB/EbfC DNA-binding family PF00004 (1/1) ATPase family associated with various cellular activities (AAA)
GCF_000647875.1	663.56 +- 614.03	2	1	0	0.03 +- 0.03	2	20 TIGR01525 (1/2) heavy metal translocating P-type ATPase TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent) PF13549 (1/2) ATP-grasp domain PF13535 (1/2) ATP-grasp domain PF13480 (1/2) Acetyltransferase (GNAT) domain PF13115 (1/2) YtkA-like PF04389 (1/2) Peptidase family M28 PF02627 (1/2) Carboxymuconolactone decarboxylase family PF01676 (1/2) Metalloenzyme superfamily PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PF00702 (1/2) haloacid dehalogenase-like hydrolase PF00664 (1/2) ABC transporter transmembrane region PF00403 (1/2) Heavy-metal-associated domain PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) PF00155 (1/2) Aminotransferase class I and II PF00122 (1/2) E1-E2 ATPase PF00117 (1/2) Glutamine amidotransferase class-I PF00005 (1/2) ABC transporter
GCF_000816465.3	975.00 +- 325.00	2	1	1	0.01 +- 0.00	2	12 TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain TIGR03605 (1/2) SagB-type dehydrogenase domain PF17933 (1/2) Tetracyclin repressor-like, C-terminal domain PF12679 (1/2) ABC-2 family transporter protein PF06100 (1/2) MCRA family PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding PF02517 (1/2) CPBP intramembrane metalloprotease PF01553 (1/2) Acyltransferase PF00881 (1/2) Nitroreductase family PF00440 (1/2) Bacterial regulatory proteins, tetR family PF00296 (1/2) Luciferase-like monooxygenase PF00005 (1/2) ABC transporter
GCF_001443625.1	2604.19 +- 3271.71	3	2	2	0.02 +- 0.04	3	No common domains found
GCF_001941275.1	346.67 +- 0.00	1	0	0	0.09 +- 0.23	1	19 TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family PF18603 (1/1) L-amino acid ligase C-terminal domain 2 PF18130 (1/1) ATP-grasp N-terminal domain PF13560 (1/1) Helix-turn-helix domain PF13535 (1/1) ATP-grasp domain PF10901 (1/1) Protein of unknown function (DUF2690) PF08443 (1/1) RimK-like ATP-grasp domain PF07690 (1/1) Major Facilitator Superfamily PF02779 (1/1) Transketolase, pyrimidine binding domain PF01546 (1/1) Peptidase family M20/M25/M40 PF01471 (1/1) Putative peptidoglycan binding domain PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family PF00696 (1/1) Amino acid kinase family PF00664 (1/1) ABC transporter transmembrane region PF00456 (1/1) Transketolase, thiamine diphosphate binding domain PF00005 (1/1) ABC transporter
GCF_001280015.1	250.83 +- 7.17	2	1	0	0.09 +- 0.22	2	34 TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase TIGR01733 (1/2) amino acid adenylation domain TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family PF18603 (1/2) L-amino acid ligase C-terminal domain 2 PF18130 (1/2) ATP-grasp N-terminal domain PF16197 (1/2) Ketoacyl-synthetase C-terminal extension PF14765 (1/2) Polyketide synthase dehydratase PF13602 (1/2) Zinc-binding dehydrogenase PF13535 (1/2) ATP-grasp domain PF13193 (1/2) AMP-binding enzyme C-terminal domain PF08990 (1/2) Erythronolide synthase docking PF08659 (1/2) KR domain PF08443 (1/2) RimK-like ATP-grasp domain PF08240 (1/2) Alcohol dehydrogenase GroES-like domain PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain PF07690 (1/2) Major Facilitator Superfamily PF03992 (1/2) Antibiotic biosynthesis monooxygenase PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain PF02779 (1/2) Transketolase, pyrimidine binding domain PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain PF01546 (1/2) Peptidase family M20/M25/M40 PF01370 (1/2) NAD dependent epimerase/dehydratase family PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family PF00975 (1/2) Thioesterase domain PF00698 (1/2) Acyl transferase domain PF00696 (1/2) Amino acid kinase family PF00668 (1/2) Condensation domain PF00550 (1/2) Phosphopantetheine attachment site PF00501 (1/2) AMP-binding enzyme PF00456 (1/2) Transketolase, thiamine diphosphate binding domain PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain PF00067 (1/2) Cytochrome P450
GCF_003846285.1	41.61 +- 0.00	1	1	0	0.10 +- 0.09	1	4 PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I PF07690 (1/1) Major Facilitator Superfamily PF00440 (1/1) Bacterial regulatory proteins, tetR family PF00067 (1/1) Cytochrome P450
GCF_004196115.1	440.26 +- 0.00	1	1	0	0.09 +- 0.09	1	25 TIGR01746 (1/1) thioester reductase domain TIGR01733 (1/1) amino acid adenylation domain TIGR01525 (1/1) heavy metal translocating P-type ATPase TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III PF13193 (1/1) AMP-binding enzyme C-terminal domain PF10862 (1/1) FcoT-like thioesterase domain PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PF07993 (1/1) Male sterility protein PF07690 (1/1) Major Facilitator Superfamily PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase PF04314 (1/1) Copper chaperone PCu(A)C PF03929 (1/1) PepSY-associated TM region PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family PF01965 (1/1) DJ-1/PfpI family PF01794 (1/1) Ferric reductase like transmembrane component PF01497 (1/1) Periplasmic binding protein PF01032 (1/1) FecCD transport family PF00702 (1/1) haloacid dehalogenase-like hydrolase PF00668 (1/1) Condensation domain PF00550 (1/1) Phosphopantetheine attachment site PF00501 (1/1) AMP-binding enzyme PF00403 (1/1) Heavy-metal-associated domain PF00122 (1/1) E1-E2 ATPase PF00005 (1/1) ABC transporter
GCF_002803155.1	60.00 +- 0.00	1	0	0	0.05 +- 0.07	1	11 PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase PF13333 (1/1) Integrase core domain PF13276 (1/1) HTH-like domain PF07690 (1/1) Major Facilitator Superfamily PF04309 (1/1) Glycerol-3-phosphate responsive antiterminator PF02913 (1/1) FAD linked oxidases, C-terminal domain PF02782 (1/1) FGGY family of carbohydrate kinases, C-terminal domain PF01565 (1/1) FAD binding domain PF01527 (1/1) Transposase PF00665 (1/1) Integrase core domain PF00370 (1/1) FGGY family of carbohydrate kinases, N-terminal domain
GCF_003367645.1	209.79 +- 255.39	4	1	1	0.05 +- 0.06	4	No common domains found
GCF_000716935.1	386.46 +- 260.58	5	2	1	0.04 +- 0.11	5	No common domains found

Entry name

Average score

Number of operons

Number of MIBiG operons

Number of operons with antismash overlap

Nr of operons with known RiPP domains

Average COG score

Nr of operons passed filter

Common domains

GCF_001705785.1

177.99 +- 112.62

0.05 +- 0.05

PF07690 (3/5) Major Facilitator Superfamily

GCF_000716515.1

44.23 +- 0.00

0.07 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_004125265.1

466.63 +- 589.37

0.03 +- 0.05

PF00067 (2/3) Cytochrome P450

GCF_000720455.1

217.83 +- 233.93

0.04 +- 0.03

No common domains found

GCF_000721625.1

116.85 +- 0.00

0.09 +- 0.21

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF13575 (1/1) Domain of unknown function (DUF4135)
PF03412 (1/1) Peptidase C39 family
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00664 (1/1) ABC transporter transmembrane region
PF00067 (1/1) Cytochrome P450
PF00005 (1/1) ABC transporter

GCF_004195745.1

107.50 +- 0.00

0.02 +- 0.02

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00561 (1/1) alpha/beta hydrolase fold

GCF_002551345.1

545.43 +- 410.74

0.02 +- 0.02

PF00005 (2/3) ABC transporter

GCF_000966955.1

335.43 +- 221.84

0.03 +- 0.03

PF13377 (2/3) Periplasmic binding protein-like domain
PF02065 (2/3) Melibiase
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00356 (2/3) Bacterial regulatory proteins, lacI family

GCF_002019855.1

577.06 +- 772.10

0.04 +- 0.08

No common domains found

GCF_001414545.1

1419.00 +- 0.00

0.01 +- 0.00

PF16197 (1/1) Ketoacyl-synthetase C-terminal extension
PF14765 (1/1) Polyketide synthase dehydratase
PF13191 (1/1) AAA ATPase domain
PF08659 (1/1) KR domain
PF04820 (1/1) Tryptophan halogenase
PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03704 (1/1) Bacterial transcriptional activator domain
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01613 (1/1) Flavin reductase like domain
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00698 (1/1) Acyl transferase domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_002551105.1

451.50 +- 0.00

0.02 +- 0.02

PF05147 (1/1) Lanthionine synthetase C-like protein
PF04672 (1/1) S-adenosyl methyltransferase
PF00664 (1/1) ABC transporter transmembrane region
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter

GCF_002154385.1

113.75 +- 0.00

0.03 +- 0.01

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)

GCF_000163875.1

418.54 +- 378.23

0.02 +- 0.05

TIGR01509 (2/2) HAD hydrolase, family IA, variant 3
PF13419 (2/2) Haloacid dehalogenase-like hydrolase
PF18181 (1/2) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (1/2) Dimerisation domain
PF14015 (1/2) Protein of unknown function (DUF4231)
PF13692 (1/2) Glycosyl transferases group 1
PF13676 (1/2) TIR domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13292 (1/2) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (1/2) Maltose acetyltransferase
PF11941 (1/2) Domain of unknown function (DUF3459)
PF08386 (1/2) TAP-like protein
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF05729 (1/2) NACHT domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF02388 (1/2) FemAB family
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00202 (1/2) Aminotransferase class-III
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)

GCF_000718855.1

91.45 +- 44.83

0.05 +- 0.05

No common domains found

GCF_000384175.1

231.24 +- 173.22

0.04 +- 0.05

No common domains found

GCF_004195855.1

21.50 +- 0.00

0.09 +- 0.05

PF17074 (1/1) Darcynin, domain of unknown function
PF08021 (1/1) Siderophore-interacting FAD-binding domain
PF04954 (1/1) Siderophore-interacting protein
PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase

GCF_000717245.1

451.50 +- 0.00

0.02 +- 0.00

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF03466 (1/1) LysR substrate binding domain
PF02310 (1/1) B12 binding domain
PF00733 (1/1) Asparagine synthase
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family

GCF_003945525.1

1161.00 +- 0.00

0.01 +- 0.00

TIGR01187 (1/1) polyamine ABC transporter, ATP-binding protein
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13416 (1/1) Bacterial extracellular solute-binding protein
PF09339 (1/1) IclR helix-turn-helix domain
PF08402 (1/1) TOBE domain
PF04199 (1/1) Putative cyclase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter

GCF_001279695.1

493.22 +- 395.49

0.04 +- 0.06

PF07690 (2/3) Major Facilitator Superfamily

GCF_004000405.1

26.96 +- 0.00

0.07 +- 0.11

TIGR01525 (1/1) heavy metal translocating P-type ATPase
PF04314 (1/1) Copper chaperone PCu(A)C
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00069 (1/1) Protein kinase domain

GCF_003287915.1

355.13 +- 136.45

0.01 +- 0.01

No common domains found

GCF_001418415.1

709.50 +- 64.50

0.01 +- 0.00

TIGR03296 (1/2) M6 family metalloprotease domain
PF14759 (1/2) Reductase C-terminal
PF13279 (1/2) Thioesterase-like superfamily
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF01613 (1/2) Flavin reductase like domain
PF00775 (1/2) Dioxygenase
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00082 (1/2) Subtilase family
PF00067 (1/2) Cytochrome P450

GCF_000698495.1

186.43 +- 36.43

0.02 +- 0.01

PF07690 (2/2) Major Facilitator Superfamily
PF13649 (1/2) Methyltransferase domain
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF00884 (1/2) Sulfatase

GCF_003950055.1

702.00 +- 0.00

0.01 +- 0.01

TIGR00710 (1/1) drug resistance transporter, Bcr/CflA subfamily
PF07690 (1/1) Major Facilitator Superfamily
PF03737 (1/1) Aldolase/RraA
PF03466 (1/1) LysR substrate binding domain
PF01361 (1/1) Tautomerase enzyme
PF00994 (1/1) Probable molybdopterin binding domain
PF00682 (1/1) HMGL-like
PF00180 (1/1) Isocitrate/isopropylmalate dehydrogenase
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family

GCF_000373625.1

147.43 +- 0.00

0.03 +- 0.01

PF07702 (1/1) UTRA domain
PF04055 (1/1) Radical SAM superfamily
PF00392 (1/1) Bacterial regulatory proteins, gntR family

GCF_000720635.1

339.65 +- 407.90

0.03 +- 0.07

No common domains found

GCF_001279775.1

127.32 +- 67.68

0.06 +- 0.12

TIGR00167 (1/2) ketose-bisphosphate aldolase
PF17042 (1/2) Nucleotide-binding C-terminal domain
PF14833 (1/2) NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13407 (1/2) Periplasmic binding protein domain
PF13401 (1/2) AAA domain
PF13185 (1/2) GAF domain
PF10009 (1/2) Uncharacterized protein conserved in bacteria (DUF2252)
PF09851 (1/2) Short C-terminal domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08447 (1/2) PAS fold
PF07729 (1/2) FCD domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF07005 (1/2) Sugar-binding N-terminal domain
PF04203 (1/2) Sortase domain
PF03631 (1/2) Virulence factor BrkB
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF02447 (1/2) GntP family permease
PF01614 (1/2) Bacterial transcriptional regulator
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
PF00781 (1/2) Diacylglycerol kinase catalytic domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_001542625.1

1118.45 +- 427.23

0.05 +- 0.16

PF00005 (3/4) ABC transporter
PF00664 (2/4) ABC transporter transmembrane region

GCF_003573485.1

361.59 +- 147.35

0.03 +- 0.10

PF07690 (3/5) Major Facilitator Superfamily
PF04055 (3/5) Radical SAM superfamily

GCF_000331185.1

243.75 +- 113.75

0.03 +- 0.01

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12833 (1/2) Helix-turn-helix domain
PF03621 (1/2) MbtH-like protein
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02311 (1/2) AraC-like ligand binding domain
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00005 (1/2) ABC transporter

GCF_003550235.1

961.81 +- 1674.31

0.03 +- 0.06

No common domains found

GCF_003846155.1

314.58 +- 326.85

0.05 +- 0.08

No common domains found

GCF_002573955.1

211.02 +- 229.41

0.08 +- 0.14

PF00534 (2/3) Glycosyl transferases group 1

GCF_000716845.1

131.15 +- 44.17

0.03 +- 0.04

No common domains found

GCF_003634815.1

659.57 +- 501.43

0.05 +- 0.11

PF17676 (1/2) LD-carboxypeptidase C-terminal domain
PF13641 (1/2) Glycosyltransferase like family 2
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13280 (1/2) WYL domain
PF10823 (1/2) Protein of unknown function (DUF2568)
PF09335 (1/2) SNARE associated Golgi protein
PF08279 (1/2) HTH domain
PF07690 (1/2) Major Facilitator Superfamily
PF05977 (1/2) Transmembrane secretion effector
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04672 (1/2) S-adenosyl methyltransferase
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF02016 (1/2) LD-carboxypeptidase N-terminal domain
PF01810 (1/2) LysE type translocator
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00925 (1/2) GTP cyclohydrolase II
PF00730 (1/2) HhH-GPD superfamily base excision DNA repair protein
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00400 (1/2) WD domain, G-beta repeat
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00293 (1/2) NUDIX domain
PF00152 (1/2) tRNA synthetases class II (D, K and N)
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter

GCF_000424805.1

621.11 +- 413.12

0.01 +- 0.00

No common domains found

GCF_001905025.1

946.35 +- 1049.91

0.03 +- 0.04

No common domains found

GCF_000403665.1

137.00 +- 97.00

0.05 +- 0.04

TIGR04451 (1/2) lantipeptide, SCO0268 family
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/2) MarR family
PF12697 (1/2) Alpha/beta hydrolase family
PF11303 (1/2) Protein of unknown function (DUF3105)
PF09335 (1/2) SNARE associated Golgi protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF02388 (1/2) FemAB family
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00507 (1/2) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00480 (1/2) ROK family

GCF_001748305.1

675.20 +- 959.81

0.02 +- 0.03

No common domains found

GCF_001723055.1

584.29 +- 0.00

0.01 +- 0.01

PF13560 (1/1) Helix-turn-helix domain
PF13424 (1/1) Tetratricopeptide repeat
PF13411 (1/1) MerR HTH family regulatory protein
PF10026 (1/1) Predicted Zn-dependent protease (DUF2268)
PF08386 (1/1) TAP-like protein
PF07739 (1/1) TipAS antibiotic-recognition domain
PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

GCF_000764715.1

192.17 +- 107.96

0.03 +- 0.04

PF07690 (2/4) Major Facilitator Superfamily
PF00348 (2/4) Polyprenyl synthetase

GCF_000719555.1

325.00 +- 130.00

0.04 +- 0.02

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13535 (1/2) ATP-grasp domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01061 (1/2) ABC-2 type transporter
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00106 (1/2) short chain dehydrogenase
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_001469455.2

365.24 +- 368.41

0.06 +- 0.16

PF01636 (2/3) Phosphotransferase enzyme family
PF00005 (2/3) ABC transporter

GCF_001279725.1

336.71 +- 263.79

0.04 +- 0.10

No common domains found

GCF_000721235.1

252.97 +- 0.00

0.09 +- 0.25

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13601 (1/1) Winged helix DNA-binding domain
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04820 (1/1) Tryptophan halogenase
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_001660045.1

43.00 +- 0.00

0.05 +- 0.04

PF01872 (1/1) RibD C-terminal domain
PF00383 (1/1) Cytidine and deoxycytidylate deaminase zinc-binding region

GCF_003721215.1

516.00 +- 0.00

0.01 +- 0.00

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF12697 (1/2) Alpha/beta hydrolase family
PF11706 (1/2) CGNR zinc finger
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF07336 (1/2) Putative stress-induced transcription regulator
PF01613 (1/2) Flavin reductase like domain
PF01381 (1/2) Helix-turn-helix
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00239 (1/2) Resolvase, N terminal domain

GCF_001905045.1

796.26 +- 610.92

0.02 +- 0.02

PF00005 (2/3) ABC transporter

GCF_002080455.1

258.72 +- 14.97

0.06 +- 0.16

TIGR03797 (1/2) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (1/2) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
PF13459 (1/2) 4Fe-4S single cluster domain
PF13437 (1/2) HlyD family secretion protein
PF10604 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF10589 (1/2) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (1/2) TAP-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF05013 (1/2) N-formylglutamate amidohydrolase
PF03640 (1/2) Secreted repeat of unknown function
PF03412 (1/2) Peptidase C39 family
PF03055 (1/2) Retinal pigment epithelial membrane protein
PF01512 (1/2) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00664 (1/2) ABC transporter transmembrane region
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter

GCF_000974485.1

767.23 +- 830.75

0.01 +- 0.01

No common domains found

GCF_000797385.1

1170.00 +- 0.00

0.01 +- 0.00

TIGR01733 (1/1) amino acid adenylation domain
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/1) Enolase C-terminal domain-like
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF12146 (1/1) Serine aminopeptidase, S33
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF03321 (1/1) GH3 auxin-responsive promoter
PF02826 (1/1) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00694 (1/1) Aconitase C-terminal domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00330 (1/1) Aconitase family (aconitate hydratase)

GCF_002291145.1

175.87 +- 64.46

0.08 +- 0.14

No common domains found

GCF_001632865.1

67.10 +- 0.00

0.06 +- 0.08

PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase

GCF_900114215.1

35.86 +- 0.00

0.06 +- 0.07

PF13581 (1/1) Histidine kinase-like ATPase domain
PF04055 (1/1) Radical SAM superfamily
PF01928 (1/1) CYTH domain

GCF_000721685.1

715.00 +- 0.00

0.03 +- 0.01

GCF_000958545.1

113.64 +- 58.36

0.05 +- 0.05

TIGR01910 (1/2) peptidase, ArgE/DapE family
PF13471 (1/2) Transglutaminase-like superfamily
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (1/2) Peptidase family M20/M25/M40
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00733 (1/2) Asparagine synthase
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter

GCF_001426585.1

726.06 +- 500.77

0.02 +- 0.01

PF07690 (2/4) Major Facilitator Superfamily

GCF_002846455.1

696.60 +- 0.00

0.01 +- 0.00

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03797 (1/1) NHLM bacteriocin system ABC transporter, ATP-binding protein
TIGR03796 (1/1) NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF13437 (1/1) HlyD family secretion protein
PF03412 (1/1) Peptidase C39 family
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter

GCF_002910775.2

462.25 +- 247.25

0.01 +- 0.01

TIGR00126 (1/2) deoxyribose-phosphate aldolase
PF13407 (1/2) Periplasmic binding protein domain
PF07702 (1/2) UTRA domain
PF06737 (1/2) Transglycosylase-like domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01476 (1/2) LysM domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter

GCF_002154275.1

212.47 +- 0.00

0.04 +- 0.05

TIGR00350 (1/1) cell envelope-related function transcriptional attenuator common domain
PF13399 (1/1) LytR cell envelope-related transcriptional attenuator
PF07859 (1/1) alpha/beta hydrolase fold
PF03816 (1/1) Cell envelope-related transcriptional attenuator domain
PF03807 (1/1) NADP oxidoreductase coenzyme F420-dependent
PF01258 (1/1) Prokaryotic dksA/traR C4-type zinc finger
PF00768 (1/1) D-alanyl-D-alanine carboxypeptidase
PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family
PF00459 (1/1) Inositol monophosphatase family

GCF_003116755.1

711.34 +- 62.66

0.02 +- 0.03

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13377 (1/2) Periplasmic binding protein-like domain
PF12730 (1/2) ABC-2 family transporter protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain

GCF_001514055.1

463.82 +- 365.79

0.01 +- 0.02

No common domains found

GCF_003116775.1

336.52 +- 0.00

0.03 +- 0.03

GCF_001748165.1

282.06 +- 245.26

0.02 +- 0.01

PF14759 (2/3) Reductase C-terminal
PF07992 (2/3) Pyridine nucleotide-disulphide oxidoreductase

GCF_000411495.1

35.45 +- 0.00

0.08 +- 0.12

PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase

GCF_000695235.1

594.27 +- 356.75

0.02 +- 0.02

No common domains found

GCF_003116715.1

224.15 +- 85.45

0.04 +- 0.12

TIGR02124 (1/2) hydrogenase expression/formation protein HypE
TIGR01891 (1/2) amidohydrolase
TIGR00709 (1/2) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (1/2) carbamoyltransferase HypF
PF17788 (1/2) HypF Kae1-like domain
PF13535 (1/2) ATP-grasp domain
PF13374 (1/2) Tetratricopeptide repeat
PF13191 (1/2) AAA ATPase domain
PF12680 (1/2) SnoaL-like domain
PF10502 (1/2) Signal peptidase, peptidase S26
PF07690 (1/2) Major Facilitator Superfamily
PF07503 (1/2) HypF finger
PF07291 (1/2) Methylamine utilisation protein MauE
PF05977 (1/2) Transmembrane secretion effector
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF02254 (1/2) TrkA-N domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01300 (1/2) Telomere recombination
PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase
PF00857 (1/2) Isochorismatase family
PF00717 (1/2) Peptidase S24-like
PF00708 (1/2) Acylphosphatase
PF00664 (1/2) ABC transporter transmembrane region
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00005 (1/2) ABC transporter

GCF_003386845.1

221.43 +- 286.26

0.04 +- 0.08

PF18085 (2/4) Maltokinase N-terminal cap domain

GCF_004005495.1

191.87 +- 107.74

0.06 +- 0.06

PF01546 (2/2) Peptidase family M20/M25/M40
TIGR01928 (1/2) o-succinylbenzoate synthase
TIGR01910 (1/2) peptidase, ArgE/DapE family
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13520 (1/2) Amino acid permease
PF13378 (1/2) Enolase C-terminal domain-like
PF13354 (1/2) Beta-lactamase enzyme family
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07969 (1/2) Amidohydrolase family
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF03061 (1/2) Thioesterase superfamily
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (1/2) Prolyl oligopeptidase family
PF00202 (1/2) Aminotransferase class-III
PF00171 (1/2) Aldehyde dehydrogenase family
PF00144 (1/2) Beta-lactamase
PF00005 (1/2) ABC transporter

GCF_002705975.1

405.43 +- 0.00

0.03 +- 0.03

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF09265 (1/1) Cytokinin dehydrogenase 1, FAD and cytokinin binding
PF06236 (1/1) Tyrosinase co-factor MelC1
PF01565 (1/1) FAD binding domain
PF01156 (1/1) Inosine-uridine preferring nucleoside hydrolase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00294 (1/1) pfkB family carbohydrate kinase
PF00264 (1/1) Common central domain of tyrosinase

GCF_000590515.1

163.58 +- 75.48

0.05 +- 0.05

No common domains found

GCF_002154345.1

268.60 +- 186.69

0.06 +- 0.06

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13411 (1/2) MerR HTH family regulatory protein
PF12730 (1/2) ABC-2 family transporter protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03476 (1/2) MOSC N-terminal beta barrel domain
PF03473 (1/2) MOSC domain
PF03412 (1/2) Peptidase C39 family
PF01551 (1/2) Peptidase family M23
PF00664 (1/2) ABC transporter transmembrane region
PF00248 (1/2) Aldo/keto reductase family
PF00005 (1/2) ABC transporter

GCF_001279855.1

531.82 +- 0.00

0.03 +- 0.01

TIGR01426 (1/1) glycosyltransferase, MGT family
PF17914 (1/1) HopA1 effector protein family
PF13692 (1/1) Glycosyl transferases group 1
PF13601 (1/1) Winged helix DNA-binding domain
PF12698 (1/1) ABC-2 family transporter protein
PF05719 (1/1) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00201 (1/1) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/1) ABC transporter

GCF_003663895.1

158.81 +- 2.44

0.05 +- 0.05

TIGR01766 (1/2) transposase, IS605 OrfB family
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF09206 (1/2) Alpha-L-arabinofuranosidase B, catalytic
PF07971 (1/2) Glycosyl hydrolase family 92
PF07282 (1/2) Putative transposase DNA-binding domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02057 (1/2) Glycosyl hydrolase family 59
PF01385 (1/2) Probable transposase
PF01229 (1/2) Glycosyl hydrolases family 39
PF00672 (1/2) HAMP domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00553 (1/2) Cellulose binding domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00331 (1/2) Glycosyl hydrolase family 10
PF00072 (1/2) Response regulator receiver domain

GCF_002155915.1

1548.00 +- 0.00

0.01 +- 0.00

TIGR04353 (1/1) PqqD family protein, HPr-rel-A system
PF13646 (1/1) HEAT repeats
PF13471 (1/1) Transglutaminase-like superfamily
PF13411 (1/1) MerR HTH family regulatory protein
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_003032475.1

422.69 +- 228.50

0.06 +- 0.16

PF00005 (2/3) ABC transporter

GCF_002150735.1

405.29 +- 374.71

0.01 +- 0.03

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR03892 (1/2) thiazolylpeptide-type bacteriocin precursor
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF06821 (1/2) Serine hydrolase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04055 (1/2) Radical SAM superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02310 (1/2) B12 binding domain
PF00106 (1/2) short chain dehydrogenase

GCF_000377165.1

354.16 +- 244.08

0.05 +- 0.08

No common domains found

GCF_000718295.1

71.86 +- 41.63

0.08 +- 0.08

No common domains found

GCF_001984575.1

217.69 +- 0.00

0.06 +- 0.07

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF12802 (1/1) MarR family
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00326 (1/1) Prolyl oligopeptidase family
PF00069 (1/1) Protein kinase domain

GCF_001570645.1

239.66 +- 136.25

0.04 +- 0.05

PF07690 (3/6) Major Facilitator Superfamily

GCF_000720675.1

404.00 +- 238.14

0.03 +- 0.02

TIGR00928 (1/2) adenylosuccinate lyase
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13460 (1/2) NAD(P)H-binding
PF12800 (1/2) 4Fe-4S binding domain
PF07690 (1/2) Major Facilitator Superfamily
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01494 (1/2) FAD binding domain
PF01425 (1/2) Amidase
PF00703 (1/2) Glycosyl hydrolases family 2
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00206 (1/2) Lyase
PF00120 (1/2) Glutamine synthetase, catalytic domain
PF00072 (1/2) Response regulator receiver domain

GCF_002803845.1

1334.14 +- 511.29

0.01 +- 0.01

PF13649 (3/4) Methyltransferase domain
PF05193 (3/4) Peptidase M16 inactive domain
PF00675 (3/4) Insulinase (Peptidase family M16)
PF00005 (3/4) ABC transporter
PF17914 (2/4) HopA1 effector protein family
PF02441 (2/4) Flavoprotein
PF01636 (2/4) Phosphotransferase enzyme family

GCF_001279815.1

531.82 +- 0.00

0.03 +- 0.01

GCF_001485145.1

140.70 +- 66.23

0.06 +- 0.07

No common domains found

GCF_003751985.1

251.55 +- 0.00

0.05 +- 0.01

PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08386 (1/1) TAP-like protein
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/1) Cupin domain
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01636 (1/1) Phosphotransferase enzyme family
PF01593 (1/1) Flavin containing amine oxidoreductase
PF01381 (1/1) Helix-turn-helix
PF00561 (1/1) alpha/beta hydrolase fold
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00202 (1/1) Aminotransferase class-III
PF00171 (1/1) Aldehyde dehydrogenase family
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_001704275.1

1376.96 +- 1872.70

0.02 +- 0.02

No common domains found

GCF_002128305.1

451.50 +- 0.00

0.01 +- 0.00

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF08241 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF02310 (1/1) B12 binding domain
PF00326 (1/1) Prolyl oligopeptidase family

GCF_000426325.1

97.13 +- 73.68

0.08 +- 0.07

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

GCF_000988945.1

196.81 +- 147.19

0.04 +- 0.03

PF13478 (1/2) XdhC Rossmann domain
PF09339 (1/2) IclR helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF06772 (1/2) Bacterial low temperature requirement A protein (LtrA)
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (1/2) XdhC and CoxI family
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00561 (1/2) alpha/beta hydrolase fold
PF00296 (1/2) Luciferase-like monooxygenase
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00106 (1/2) short chain dehydrogenase

GCF_001905785.1

706.54 +- 331.59

0.04 +- 0.06

PF00005 (3/3) ABC transporter

GCF_003949795.1

65.00 +- 0.00

0.03 +- 0.02

TIGR03619 (1/1) probable F420-dependent oxidoreductase, Rv2161c family
PF01814 (1/1) Hemerythrin HHE cation binding domain
PF00296 (1/1) Luciferase-like monooxygenase

GCF_001008135.1

144.48 +- 0.00

0.06 +- 0.06

PF17900 (1/1) Peptidase M1 N-terminal domain
PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain
PF02423 (1/1) Ornithine cyclodeaminase/mu-crystallin family
PF01965 (1/1) DJ-1/PfpI family
PF01433 (1/1) Peptidase family M1 domain
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00082 (1/1) Subtilase family

GCF_003550195.1

184.29 +- 0.00

0.06 +- 0.03

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF12802 (1/1) MarR family
PF12697 (1/1) Alpha/beta hydrolase family
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF02894 (1/1) Oxidoreductase family, C-terminal alpha/beta domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00480 (1/1) ROK family

GCF_000720645.1

340.31 +- 456.82

0.04 +- 0.05

PF07690 (2/4) Major Facilitator Superfamily
PF00440 (2/4) Bacterial regulatory proteins, tetR family
PF00067 (2/4) Cytochrome P450

GCF_900092005.1

686.05 +- 83.95

0.03 +- 0.03

GCF_003024195.1

624.48 +- 646.35

0.05 +- 0.08

PF07690 (2/4) Major Facilitator Superfamily
PF00486 (2/4) Transcriptional regulatory protein, C terminal

GCF_003751175.1

68.76 +- 5.52

0.08 +- 0.04

TIGR02133 (1/2) ribose 5-phosphate isomerase
PF16896 (1/2) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (1/2) Major Facilitator Superfamily
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02734 (1/2) DAK2 domain
PF02733 (1/2) Dak1 domain
PF02502 (1/2) Ribose/Galactose Isomerase
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00121 (1/2) Triosephosphate isomerase

GCF_001267885.1

516.00 +- 0.00

0.01 +- 0.00

PF03446 (1/1) NAD binding domain of 6-phosphogluconate dehydrogenase

GCF_002154675.1

334.55 +- 147.68

0.03 +- 0.07

No common domains found

GCF_900215305.1

911.66 +- 731.76

0.02 +- 0.05

No common domains found

GCF_004195735.1

161.25 +- 0.00

0.01 +- 0.01

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00931 (1/1) NB-ARC domain
PF00561 (1/1) alpha/beta hydrolase fold

GCF_004195835.1

416.79 +- 0.00

0.10 +- 0.15

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter

GCF_002846295.1

192.12 +- 144.86

0.05 +- 0.16

No common domains found

GCF_000385945.1

433.75 +- 32.28

0.06 +- 0.15

PF00005 (2/2) ABC transporter
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13549 (1/2) ATP-grasp domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF13115 (1/2) YtkA-like
PF12697 (1/2) Alpha/beta hydrolase family
PF12679 (1/2) ABC-2 family transporter protein
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (1/2) Amidohydrolase
PF04389 (1/2) Peptidase family M28
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02222 (1/2) ATP-grasp domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01676 (1/2) Metalloenzyme superfamily
PF01144 (1/2) Coenzyme A transferase
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00501 (1/2) AMP-binding enzyme
PF00403 (1/2) Heavy-metal-associated domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00122 (1/2) E1-E2 ATPase
PF00117 (1/2) Glutamine amidotransferase class-I
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase

GCF_002009175.1

520.00 +- 0.00

0.01 +- 0.00

PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF00676 (1/1) Dehydrogenase E1 component
PF00550 (1/1) Phosphopantetheine attachment site
PF00364 (1/1) Biotin-requiring enzyme
PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

GCF_002551475.1

1665.00 +- 675.00

0.01 +- 0.00

PF00005 (2/2) ABC transporter
TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12679 (1/2) ABC-2 family transporter protein
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04978 (1/2) Protein of unknown function (DUF664)
PF03412 (1/2) Peptidase C39 family
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00296 (1/2) Luciferase-like monooxygenase

GCF_900105695.1

1271.11 +- 0.00

0.01 +- 0.00

TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF02983 (1/1) Alpha-lytic protease prodomain
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (1/1) Luciferase-like monooxygenase
PF00089 (1/1) Trypsin
PF00005 (1/1) ABC transporter

GCF_000424845.1

127.68 +- 0.00

0.09 +- 0.07

TIGR01972 (1/1) proton-translocating NADH-quinone oxidoreductase, chain M
PF13581 (1/1) Histidine kinase-like ATPase domain
PF00507 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
PF00499 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase chain 6
PF00420 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
PF00361 (1/1) Proton-conducting membrane transporter
PF00146 (1/1) NADH dehydrogenase

GCF_003369795.1

204.75 +- 169.83

0.06 +- 0.10

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF13454 (1/2) FAD-NAD(P)-binding
PF12006 (1/2) Protein of unknown function (DUF3500)
PF07920 (1/2) Protein of unknown function (DUF1684)
PF07690 (1/2) Major Facilitator Superfamily
PF06912 (1/2) Protein of unknown function (DUF1275)
PF04055 (1/2) Radical SAM superfamily
PF03737 (1/2) Aldolase/RraA
PF02983 (1/2) Alpha-lytic protease prodomain
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF01494 (1/2) FAD binding domain
PF01061 (1/2) ABC-2 type transporter
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00160 (1/2) Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
PF00155 (1/2) Aminotransferase class I and II
PF00089 (1/2) Trypsin
PF00005 (1/2) ABC transporter

GCF_000156695.2

668.57 +- 0.00

0.03 +- 0.01

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12679 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter

GCF_001485105.1

417.31 +- 63.89

0.05 +- 0.19

PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme

GCF_001419685.1

371.73 +- 323.85

0.04 +- 0.03

No common domains found

GCF_001983975.1

193.50 +- 0.00

0.02 +- 0.02

PF14759 (1/1) Reductase C-terminal
PF14016 (1/1) Protein of unknown function (DUF4232)
PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

GCF_004195845.1

175.38 +- 0.00

0.07 +- 0.11

TIGR01182 (1/1) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF14315 (1/1) Domain of unknown function (DUF4380)
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13407 (1/1) Periplasmic binding protein domain
PF13378 (1/1) Enolase C-terminal domain-like
PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07729 (1/1) FCD domain
PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF01081 (1/1) KDPG and KHG aldolase
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00107 (1/1) Zinc-binding dehydrogenase
PF00005 (1/1) ABC transporter

GCF_000719605.1

642.50 +- 832.93

0.04 +- 0.09

PF07690 (2/3) Major Facilitator Superfamily

GCF_002813165.1

283.02 +- 136.54

0.04 +- 0.06

No common domains found

GCF_001905595.1

942.43 +- 998.33

0.04 +- 0.16

PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter

GCF_003116685.1

1955.65 +- 1435.65

0.01 +- 0.03

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
PF13203 (1/2) Putative metallopeptidase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12730 (1/2) ABC-2 family transporter protein
PF12697 (1/2) Alpha/beta hydrolase family
PF09967 (1/2) VWA-like domain (DUF2201)
PF08242 (1/2) Methyltransferase domain
PF07730 (1/2) Histidine kinase
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF06722 (1/2) Protein of unknown function (DUF1205)
PF03621 (1/2) MbtH-like protein
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_001279345.1

759.18 +- 1395.80

0.05 +- 0.13

No common domains found

GCF_000738695.1

392.10 +- 367.46

0.04 +- 0.15

No common domains found

GCF_000716745.1

124.03 +- 35.65

0.03 +- 0.02

No common domains found

GCF_000717965.1

241.43 +- 0.00

0.02 +- 0.01

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF15644 (1/1) Papain fold toxin 1, glutamine deamidase
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain

GCF_000709915.1

23.11 +- 0.00

0.09 +- 0.08

PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF03713 (1/1) Domain of unknown function (DUF305)

GCF_003955715.1

532.12 +- 467.62

0.05 +- 0.17

TIGR04364 (1/2) methyltransferase, FxLD system
TIGR04363 (1/2) FxLD family lantipeptide
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13649 (1/2) Methyltransferase domain
PF13581 (1/2) Histidine kinase-like ATPase domain
PF12006 (1/2) Protein of unknown function (DUF3500)
PF05331 (1/2) Protein of unknown function (DUF742)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04672 (1/2) S-adenosyl methyltransferase
PF03457 (1/2) Helicase associated domain
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01636 (1/2) Phosphotransferase enzyme family
PF01590 (1/2) GAF domain
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (1/2) NUDIX domain
PF00271 (1/2) Helicase conserved C-terminal domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_003261055.1

214.50 +- 171.99

0.05 +- 0.08

No common domains found

GCF_000721365.1

1554.07 +- 2002.71

0.03 +- 0.04

PF00005 (2/3) ABC transporter

GCF_002754715.1

14352.00 +- 0.00

0.01 +- 0.00

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/1) amidohydrolase
PF14310 (1/1) Fibronectin type III-like domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF07730 (1/1) Histidine kinase
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03412 (1/1) Peptidase C39 family
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01915 (1/1) Glycosyl hydrolase family 3 C-terminal domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01061 (1/1) ABC-2 type transporter
PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain
PF00881 (1/1) Nitroreductase family
PF00664 (1/1) ABC transporter transmembrane region
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
PF00067 (1/1) Cytochrome P450
PF00005 (1/1) ABC transporter

GCF_004295505.1

128.95 +- 73.67

0.09 +- 0.07

TIGR01733 (1/2) amino acid adenylation domain
PF18029 (1/2) Glyoxalase-like domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF13471 (1/2) Transglutaminase-like superfamily
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08713 (1/2) DNA alkylation repair enzyme
PF08659 (1/2) KR domain
PF07690 (1/2) Major Facilitator Superfamily
PF07478 (1/2) D-ala D-ala ligase C-terminus
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01820 (1/2) D-ala D-ala ligase N-terminus
PF01494 (1/2) FAD binding domain
PF00975 (1/2) Thioesterase domain
PF00850 (1/2) Histone deacetylase domain
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00733 (1/2) Asparagine synthase
PF00698 (1/2) Acyl transferase domain
PF00551 (1/2) Formyl transferase
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00155 (1/2) Aminotransferase class I and II
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain

GCF_900091985.1

300.26 +- 323.57

0.05 +- 0.16

PF07690 (3/5) Major Facilitator Superfamily

GCF_001514265.1

572.85 +- 77.15

0.04 +- 0.11

PF07690 (2/2) Major Facilitator Superfamily
PF00326 (2/2) Prolyl oligopeptidase family
TIGR03567 (1/2) FMN reductase
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01484 (1/2) HAD hydrolase, family IIB
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain
PF14559 (1/2) Tetratricopeptide repeat
PF13535 (1/2) ATP-grasp domain
PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (1/2) Tetratricopeptide repeat
PF13424 (1/2) Tetratricopeptide repeat
PF09334 (1/2) tRNA synthetases class I (M)
PF08282 (1/2) haloacid dehalogenase-like hydrolase
PF08281 (1/2) Sigma-70, region 4
PF07883 (1/2) Cupin domain
PF04542 (1/2) Sigma-70 region 2
PF03358 (1/2) NADPH-dependent FMN reductase
PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02142 (1/2) MGS-like domain
PF01808 (1/2) AICARFT/IMPCHase bienzyme
PF01613 (1/2) Flavin reductase like domain
PF01259 (1/2) SAICAR synthetase
PF00709 (1/2) Adenylosuccinate synthetase
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00106 (1/2) short chain dehydrogenase

GCF_003112515.1

480.00 +- 0.00

0.01 +- 0.00

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00652 (1/1) Ricin-type beta-trefoil lectin domain

GCF_001279805.1

387.00 +- 0.00

0.01 +- 0.00

TIGR03822 (1/1) lysine-2,3-aminomutase-related protein
PF18604 (1/1) Pre ATP-grasp domain
PF18105 (1/1) PGM1 C-terminal domain
PF13649 (1/1) Methyltransferase domain
PF13480 (1/1) Acetyltransferase (GNAT) domain
PF12697 (1/1) Alpha/beta hydrolase family
PF12544 (1/1) Lysine-2,3-aminomutase
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF00144 (1/1) Beta-lactamase

GCF_000719865.1

738.95 +- 0.00

0.01 +- 0.00

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
PF13649 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF05193 (1/1) Peptidase M16 inactive domain
PF04989 (1/1) Cephalosporin hydroxylase
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF00805 (1/1) Pentapeptide repeats (8 copies)
PF00675 (1/1) Insulinase (Peptidase family M16)

GCF_003143855.1

1020.39 +- 895.05

0.03 +- 0.09

PF00775 (2/3) Dioxygenase
PF00378 (2/3) Enoyl-CoA hydratase/isomerase

GCF_000738715.1

672.64 +- 617.36

0.02 +- 0.04

TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02036 (1/2) SCP-2 sterol transfer family
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter

GCF_003846255.1

487.50 +- 0.00

0.02 +- 0.02

GCF_002551335.1

52.30 +- 0.00

0.10 +- 0.10

PF17964 (1/1) Bacterial Ig domain
PF03734 (1/1) L,D-transpeptidase catalytic domain

GCF_900105525.1

306.56 +- 112.53

0.04 +- 0.17

PF07690 (3/4) Major Facilitator Superfamily
PF00535 (2/4) Glycosyl transferase family 2
PF00196 (2/4) Bacterial regulatory proteins, luxR family

GCF_003146615.1

279.00 +- 186.14

0.06 +- 0.09

PF00005 (2/2) ABC transporter
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF12450 (1/2) von Willebrand factor
PF12034 (1/2) Domain of unknown function (DUF3520)
PF10502 (1/2) Signal peptidase, peptidase S26
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07291 (1/2) Methylamine utilisation protein MauE
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00717 (1/2) Peptidase S24-like
PF00664 (1/2) ABC transporter transmembrane region
PF00501 (1/2) AMP-binding enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00092 (1/2) von Willebrand factor type A domain

GCF_003949845.1

1027.12 +- 1027.69

0.01 +- 0.01

PF07690 (3/6) Major Facilitator Superfamily

GCF_000720725.1

241.83 +- 220.09

0.06 +- 0.10

No common domains found

GCF_001418625.1

438.94 +- 287.53

0.07 +- 0.19

TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
TIGR00218 (1/2) mannose-6-phosphate isomerase, class I
PF13549 (1/2) ATP-grasp domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13115 (1/2) YtkA-like
PF12697 (1/2) Alpha/beta hydrolase family
PF04389 (1/2) Peptidase family M28
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02222 (1/2) ATP-grasp domain
PF01676 (1/2) Metalloenzyme superfamily
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01238 (1/2) Phosphomannose isomerase type I
PF00703 (1/2) Glycosyl hydrolases family 2
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00403 (1/2) Heavy-metal-associated domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/2) Aminotransferase class I and II
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00122 (1/2) E1-E2 ATPase
PF00117 (1/2) Glutamine amidotransferase class-I
PF00005 (1/2) ABC transporter

GCF_001550215.1

75.82 +- 32.82

0.09 +- 0.14

TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02036 (1/2) SCP-2 sterol transfer family
PF00430 (1/2) ATP synthase B/B' CF(0)
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter

GCF_000719575.1

448.72 +- 157.48

0.03 +- 0.08

PF00528 (3/6) Binding-protein-dependent transport system inner membrane component

GCF_001514065.1

287.48 +- 226.00

0.03 +- 0.07

No common domains found

GCF_000718375.1

98.11 +- 0.00

0.04 +- 0.03

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family

GCF_003443735.1

506.67 +- 561.21

0.02 +- 0.02

No common domains found

GCF_000720835.1

390.00 +- 0.00

0.01 +- 0.00

PF02737 (1/1) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01613 (1/1) Flavin reductase like domain
PF00725 (1/1) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/1) Luciferase-like monooxygenase

GCF_002382885.1

699.69 +- 118.21

0.04 +- 0.06

PF00005 (2/3) ABC transporter

GCF_900110255.1

101.74 +- 0.00

0.04 +- 0.08

PF18130 (1/1) ATP-grasp N-terminal domain
PF16259 (1/1) Domain of unknown function (DUF4913)
PF13620 (1/1) Carboxypeptidase regulatory-like domain
PF13535 (1/1) ATP-grasp domain
PF12307 (1/1) Protein of unknown function (DUF3631)
PF07690 (1/1) Major Facilitator Superfamily
PF03771 (1/1) Domain of unknown function (DUF317)
PF01638 (1/1) HxlR-like helix-turn-helix
PF01555 (1/1) DNA methylase

GCF_003846265.1

218.20 +- 39.80

0.05 +- 0.07

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13191 (1/2) AAA ATPase domain
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01145 (1/2) SPFH domain / Band 7 family
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00877 (1/2) NlpC/P60 family
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00005 (1/2) ABC transporter

GCF_004217355.1

89.58 +- 0.00

0.06 +- 0.05

PF17900 (1/1) Peptidase M1 N-terminal domain
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF01433 (1/1) Peptidase family M1 domain
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00293 (1/1) NUDIX domain

GCF_003073355.1

650.00 +- 455.00

0.02 +- 0.00

TIGR00229 (1/2) PAS domain S-box protein
PF17148 (1/2) Domain of unknown function (DUF5117)
PF16353 (1/2) Domain of unknown function(DUF4981)
PF16313 (1/2) Met-zincin
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13426 (1/2) PAS domain
PF13378 (1/2) Enolase C-terminal domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF13185 (1/2) GAF domain
PF08448 (1/2) PAS fold
PF07702 (1/2) UTRA domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF06452 (1/2) Carbohydrate family 9 binding domain-like
PF02929 (1/2) Beta galactosidase small chain
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00356 (1/2) Bacterial regulatory proteins, lacI family

GCF_002189675.2

474.78 +- 305.22

0.02 +- 0.00

TIGR01490 (1/2) HAD hydrolase, family IB
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF07690 (1/2) Major Facilitator Superfamily
PF03756 (1/2) A-factor biosynthesis hotdog domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01937 (1/2) Protein of unknown function DUF89
PF01494 (1/2) FAD binding domain
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00891 (1/2) O-methyltransferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00248 (1/2) Aldo/keto reductase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

GCF_001509775.1

146.27 +- 8.62

0.06 +- 0.08

TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00350 (1/2) cell envelope-related function transcriptional attenuator common domain
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF03816 (1/2) Cell envelope-related transcriptional attenuator domain
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01258 (1/2) Prokaryotic dksA/traR C4-type zinc finger
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00459 (1/2) Inositol monophosphatase family
PF00005 (1/2) ABC transporter

GCF_001280885.1

43.00 +- 0.00

0.05 +- 0.04

PF02868 (1/1) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/1) Thermolysin metallopeptidase, catalytic domain
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

GCF_003989035.1

650.72 +- 656.33

0.03 +- 0.06

PF00005 (2/3) ABC transporter

GCF_002005565.1

2882.61 +- 0.00

0.01 +- 0.01

TIGR01830 (1/1) 3-oxoacyl-[acyl-carrier-protein] reductase
TIGR01733 (1/1) amino acid adenylation domain
TIGR01720 (1/1) non-ribosomal peptide synthase domain TIGR01720
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13279 (1/1) Thioesterase-like superfamily
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF12146 (1/1) Serine aminopeptidase, S33
PF07977 (1/1) FabA-like domain
PF07508 (1/1) Recombinase
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01323 (1/1) DSBA-like thioredoxin domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain

GCF_000725705.1

134.43 +- 171.14

0.07 +- 0.17

PF00082 (2/4) Subtilase family

GCF_002114065.1

321.24 +- 0.00

0.10 +- 0.22

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00802 (1/1) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF14237 (1/1) GYF domain 2
PF13421 (1/1) SPFH domain-Band 7 family
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/1) Sigma-70, region 4
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03824 (1/1) High-affinity nickel-transport protein
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase

GCF_002920575.1

53.77 +- 24.23

0.05 +- 0.09

PF14759 (1/2) Reductase C-terminal
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07883 (1/2) Cupin domain
PF01381 (1/2) Helix-turn-helix
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00083 (1/2) Sugar (and other) transporter

GCF_000721155.1

73.80 +- 12.86

0.06 +- 0.06

PF14158 (1/2) YndJ-like protein
PF13581 (1/2) Histidine kinase-like ATPase domain
PF13492 (1/2) GAF domain
PF13471 (1/2) Transglutaminase-like superfamily
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09348 (1/2) Domain of unknown function (DUF1990)
PF08447 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03446 (1/2) NAD binding domain of 6-phosphogluconate dehydrogenase
PF00733 (1/2) Asparagine synthase
PF00149 (1/2) Calcineurin-like phosphoesterase

GCF_001905665.1

151.67 +- 0.00

0.02 +- 0.01

PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF02897 (1/1) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF00326 (1/1) Prolyl oligopeptidase family

GCF_000717655.1

80.29 +- 11.47

0.04 +- 0.04

TIGR03296 (1/2) M6 family metalloprotease domain
PF13649 (1/2) Methyltransferase domain
PF06737 (1/2) Transglycosylase-like domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (1/2) alpha/beta hydrolase fold

GCF_001509795.1

230.00 +- 160.00

0.04 +- 0.04

PF00082 (2/2) Subtilase family
TIGR03921 (1/2) type VII secretion-associated serine protease mycosin
PF13191 (1/2) AAA ATPase domain
PF07729 (1/2) FCD domain
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (1/2) Putative Ig domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF02225 (1/2) PA domain
PF01638 (1/2) HxlR-like helix-turn-helix
PF01483 (1/2) Proprotein convertase P-domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00293 (1/2) NUDIX domain
PF00221 (1/2) Aromatic amino acid lyase
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_002939475.1

516.00 +- 0.00

0.01 +- 0.00

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03558 (1/1) luciferase family oxidoreductase, group 1
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_003751325.1

409.88 +- 324.50

0.04 +- 0.07

PF00005 (2/4) ABC transporter

GCF_002192455.1

534.60 +- 431.67

0.02 +- 0.02

PF00005 (2/3) ABC transporter

GCF_004196035.1

76.10 +- 0.00

0.05 +- 0.00

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
PF18130 (1/1) ATP-grasp N-terminal domain
PF13640 (1/1) 2OG-Fe(II) oxygenase superfamily
PF13535 (1/1) ATP-grasp domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07993 (1/1) Male sterility protein
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00106 (1/1) short chain dehydrogenase

GCF_002920535.1

234.00 +- 0.00

0.01 +- 0.01

PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF01266 (1/1) FAD dependent oxidoreductase
PF00474 (1/1) Sodium:solute symporter family

GCF_001047325.1

559.00 +- 351.00

0.02 +- 0.02

TIGR03425 (1/2) urea carboxylase-associated protein 2
TIGR03424 (1/2) urea carboxylase-associated protein 1
TIGR02712 (1/2) urea carboxylase
TIGR01930 (1/2) acetyl-CoA C-acyltransferase
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13520 (1/2) Amino acid permease
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13394 (1/2) 4Fe-4S single cluster domain
PF09347 (1/2) Domain of unknown function (DUF1989)
PF07690 (1/2) Major Facilitator Superfamily
PF06508 (1/2) Queuosine biosynthesis protein QueC
PF06368 (1/2) Methylaspartate mutase E chain (MutE)
PF02803 (1/2) Thiolase, C-terminal domain
PF02786 (1/2) Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02785 (1/2) Biotin carboxylase C-terminal domain
PF02682 (1/2) Carboxyltransferase domain, subdomain C and D
PF02626 (1/2) Carboxyltransferase domain, subdomain A and B
PF02310 (1/2) B12 binding domain
PF01425 (1/2) Amidase
PF01242 (1/2) 6-pyruvoyl tetrahydropterin synthase
PF01227 (1/2) GTP cyclohydrolase I
PF00668 (1/2) Condensation domain
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00364 (1/2) Biotin-requiring enzyme
PF00289 (1/2) Biotin carboxylase, N-terminal domain
PF00108 (1/2) Thiolase, N-terminal domain

GCF_001700515.1

845.00 +- 0.00

0.01 +- 0.01

PF13400 (1/1) Putative Flp pilus-assembly TadE/G-like
PF07730 (1/1) Histidine kinase
PF07591 (1/1) Pretoxin HINT domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00691 (1/1) OmpA family
PF00482 (1/1) Type II secretion system (T2SS), protein F
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain

GCF_000424765.1

614.55 +- 0.00

0.08 +- 0.24

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter

GCF_000721175.1

218.17 +- 133.41

0.03 +- 0.04

No common domains found

GCF_001905795.1

99.13 +- 4.07

0.05 +- 0.04

TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating)
PF13621 (1/2) Cupin-like domain
PF12740 (1/2) Chlorophyllase enzyme
PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (1/2) DmpG-like communication domain
PF07690 (1/2) Major Facilitator Superfamily
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00682 (1/2) HMGL-like
PF00155 (1/2) Aminotransferase class I and II
PF00135 (1/2) Carboxylesterase family

GCF_000719695.1

612.37 +- 199.48

0.05 +- 0.17

PF00528 (3/5) Binding-protein-dependent transport system inner membrane component

GCF_002754435.1

292.86 +- 107.14

0.04 +- 0.05

PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF08386 (1/2) TAP-like protein
PF05532 (1/2) CsbD-like
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00248 (1/2) Aldo/keto reductase family
PF00117 (1/2) Glutamine amidotransferase class-I
PF00069 (1/2) Protein kinase domain

GCF_001509785.1

347.82 +- 313.55

0.03 +- 0.05

PF00082 (3/3) Subtilase family

GCF_002335465.1

67.60 +- 36.23

0.09 +- 0.12

TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (1/2) amino acid adenylation domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13796 (1/2) Putative sensor
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12158 (1/2) Protein of unknown function (DUF3592)
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18)
PF01874 (1/2) ATP:dephospho-CoA triphosphoribosyl transferase
PF00975 (1/2) Thioesterase domain
PF00877 (1/2) NlpC/P60 family
PF00775 (1/2) Dioxygenase
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain

GCF_001418645.1

143.27 +- 0.00

0.06 +- 0.03

PF04143 (1/1) Sulphur transport
PF03466 (1/1) LysR substrate binding domain
PF03328 (1/1) HpcH/HpaI aldolase/citrate lyase family
PF02515 (1/1) CoA-transferase family III
PF00126 (1/1) Bacterial regulatory helix-turn-helix protein, lysR family

GCF_002551135.1

624.12 +- 155.88

0.06 +- 0.07

PF00005 (2/2) ABC transporter
TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04978 (1/2) Protein of unknown function (DUF664)
PF04314 (1/2) Copper chaperone PCu(A)C
PF03412 (1/2) Peptidase C39 family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase

GCF_000717665.1

148.21 +- 103.34

0.04 +- 0.04

TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07690 (1/2) Major Facilitator Superfamily
PF07179 (1/2) SseB protein N-terminal domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00106 (1/2) short chain dehydrogenase

GCF_002551375.1

678.68 +- 350.25

0.02 +- 0.01

PF00005 (3/3) ABC transporter
PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region

GCF_002551185.1

53.75 +- 0.00

0.09 +- 0.10

PF03551 (1/1) Transcriptional regulator PadR-like family
PF00975 (1/1) Thioesterase domain
PF00501 (1/1) AMP-binding enzyme
PF00248 (1/1) Aldo/keto reductase family
PF00067 (1/1) Cytochrome P450

GCF_002154555.1

265.59 +- 0.00

0.04 +- 0.07

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00802 (1/1) transition metal uptake transporter, Ni2+-Co2+ transporter (NiCoT) family
PF14237 (1/1) GYF domain 2
PF13421 (1/1) SPFH domain-Band 7 family
PF08281 (1/1) Sigma-70, region 4
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/1) Sigma-70 region 2
PF04314 (1/1) Copper chaperone PCu(A)C
PF03824 (1/1) High-affinity nickel-transport protein
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase

GCF_004078575.1

197.15 +- 0.00

0.09 +- 0.10

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter

GCF_000720685.1

91.45 +- 44.83

0.05 +- 0.05

No common domains found

GCF_000702365.1

1235.00 +- 585.00

0.01 +- 0.01

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12730 (1/2) ABC-2 family transporter protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain

GCF_000716875.1

405.43 +- 368.57

0.03 +- 0.03

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF08007 (1/2) Cupin superfamily protein
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF04055 (1/2) Radical SAM superfamily
PF01061 (1/2) ABC-2 type transporter
PF00717 (1/2) Peptidase S24-like
PF00248 (1/2) Aldo/keto reductase family
PF00005 (1/2) ABC transporter

GCF_003129505.1

74.29 +- 0.00

0.04 +- 0.04

PF13602 (1/1) Zinc-binding dehydrogenase
PF13564 (1/1) DoxX-like family
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF00296 (1/1) Luciferase-like monooxygenase
PF00106 (1/1) short chain dehydrogenase

GCF_002551415.1

442.29 +- 0.00

0.01 +- 0.00

TIGR03898 (1/1) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF13575 (1/1) Domain of unknown function (DUF4135)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter

GCF_001417695.1

236.60 +- 75.67

0.07 +- 0.06

No common domains found

GCF_000716215.1

701.91 +- 588.09

0.04 +- 0.04

TIGR03567 (1/2) FMN reductase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16653 (1/2) Saccharopine dehydrogenase C-terminal domain
PF14559 (1/2) Tetratricopeptide repeat
PF13535 (1/2) ATP-grasp domain
PF13434 (1/2) L-lysine 6-monooxygenase (NADPH-requiring)
PF13432 (1/2) Tetratricopeptide repeat
PF13424 (1/2) Tetratricopeptide repeat
PF13378 (1/2) Enolase C-terminal domain-like
PF07690 (1/2) Major Facilitator Superfamily
PF04203 (1/2) Sortase domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF02897 (1/2) Prolyl oligopeptidase, N-terminal beta-propeller domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01613 (1/2) Flavin reductase like domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00326 (1/2) Prolyl oligopeptidase family
PF00294 (1/2) pfkB family carbohydrate kinase

GCF_003074055.1

332.09 +- 206.54

0.02 +- 0.03

No common domains found

GCF_001447075.1

1040.00 +- 0.00

0.01 +- 0.00

PF08386 (1/1) TAP-like protein
PF07702 (1/1) UTRA domain
PF01380 (1/1) SIS domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_000261345.2

271.28 +- 128.05

0.06 +- 0.04

PF00005 (2/3) ABC transporter

GCF_001896135.2

260.00 +- 0.00

0.01 +- 0.00

PF03358 (1/1) NADPH-dependent FMN reductase
PF01425 (1/1) Amidase

GCF_001905855.1

101.36 +- 27.64

0.02 +- 0.03

PF12802 (1/2) MarR family
PF07681 (1/2) DoxX
PF05977 (1/2) Transmembrane secretion effector
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01261 (1/2) Xylose isomerase-like TIM barrel
PF00583 (1/2) Acetyltransferase (GNAT) family

GCF_003112575.1

129.00 +- 0.00

0.04 +- 0.02

TIGR03301 (1/1) 2-aminoethylphosphonate aminotransferase
TIGR03297 (1/1) phosphonopyruvate decarboxylase
TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF13454 (1/1) FAD-NAD(P)-binding
PF07690 (1/1) Major Facilitator Superfamily
PF04116 (1/1) Fatty acid hydroxylase superfamily
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00266 (1/1) Aminotransferase class-V

GCF_001746465.1

2824.17 +- 144.94

0.01 +- 0.01

PF00005 (2/2) ABC transporter
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13458 (1/2) Periplasmic binding protein
PF12730 (1/2) ABC-2 family transporter protein
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01425 (1/2) Amidase
PF01070 (1/2) FMN-dependent dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00682 (1/2) HMGL-like
PF00557 (1/2) Metallopeptidase family M24
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00384 (1/2) Molybdopterin oxidoreductase
PF00296 (1/2) Luciferase-like monooxygenase
PF00248 (1/2) Aldo/keto reductase family
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II
PF00069 (1/2) Protein kinase domain

GCF_000721185.1

194.57 +- 20.42

0.04 +- 0.02

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/2) alpha/beta hydrolase fold
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily

GCF_000518045.1

225.44 +- 109.76

0.01 +- 0.01

PF00884 (2/3) Sulfatase

GCF_001427245.1

442.00 +- 0.00

0.04 +- 0.05

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter

GCF_000721535.1

251.73 +- 153.90

0.03 +- 0.05

PF07690 (2/4) Major Facilitator Superfamily
PF01425 (2/4) Amidase

GCF_002551465.1

193.20 +- 145.93

0.04 +- 0.01

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12697 (1/2) Alpha/beta hydrolase family
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (1/2) Amidohydrolase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01872 (1/2) RibD C-terminal domain
PF01144 (1/2) Coenzyme A transferase
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter

GCF_000158875.1

409.10 +- 410.25

0.06 +- 0.14

No common domains found

GCF_002705665.1

229.41 +- 160.59

0.02 +- 0.03

PF07883 (1/2) Cupin domain
PF01872 (1/2) RibD C-terminal domain
PF01656 (1/2) CobQ/CobB/MinD/ParA nucleotide binding domain
PF01609 (1/2) Transposase DDE domain
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (1/2) Acetyltransferase (GNAT) family

GCF_001418655.1

148.14 +- 106.21

0.04 +- 0.04

TIGR03619 (1/2) probable F420-dependent oxidoreductase, Rv2161c family
TIGR01180 (1/2) putative alpha-1,2-mannosidase
PF17678 (1/2) Glycosyl hydrolase family 92 N-terminal domain
PF13407 (1/2) Periplasmic binding protein domain
PF07971 (1/2) Glycosyl hydrolase family 92
PF07969 (1/2) Amidohydrolase family
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00672 (1/2) HAMP domain
PF00553 (1/2) Cellulose binding domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_900103585.1

435.05 +- 416.85

0.04 +- 0.06

No common domains found

GCF_002317005.1

540.57 +- 0.00

0.07 +- 0.06

GCF_002242805.1

256.59 +- 82.97

0.04 +- 0.16

No common domains found

GCF_000377525.1

5460.00 +- 0.00

0.01 +- 0.00

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_001886595.1

187.39 +- 133.37

0.02 +- 0.01

No common domains found

GCF_900091315.1

737.77 +- 250.44

0.02 +- 0.03

PF04055 (2/3) Radical SAM superfamily

GCF_002803195.1

453.12 +- 406.37

0.03 +- 0.05

No common domains found

GCF_000717915.1

327.88 +- 155.87

0.02 +- 0.02

TIGR00928 (1/2) adenylosuccinate lyase
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13454 (1/2) FAD-NAD(P)-binding
PF10397 (1/2) Adenylosuccinate lyase C-terminus
PF08386 (1/2) TAP-like protein
PF07969 (1/2) Amidohydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03704 (1/2) Bacterial transcriptional activator domain
PF01425 (1/2) Amidase
PF00931 (1/2) NB-ARC domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00206 (1/2) Lyase
PF00120 (1/2) Glutamine synthetase, catalytic domain

GCF_000721525.1

309.60 +- 0.00

0.01 +- 0.00

PF06628 (1/1) Catalase-related immune-responsive
PF01475 (1/1) Ferric uptake regulator family
PF00248 (1/1) Aldo/keto reductase family
PF00199 (1/1) Catalase

GCF_000720505.1

57.33 +- 0.00

0.07 +- 0.03

PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF13649 (1/1) Methyltransferase domain
PF13535 (1/1) ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF01794 (1/1) Ferric reductase like transmembrane component
PF00291 (1/1) Pyridoxal-phosphate dependent enzyme

GCF_000383655.1

258.00 +- 0.00

0.01 +- 0.00

TIGR04276 (1/1) FxsC C-terminal domain
TIGR04269 (1/1) radical SAM/SPASM domain protein, FxsB family
TIGR04267 (1/1) HEXXH motif domain
PF13676 (1/1) TIR domain
PF13424 (1/1) Tetratricopeptide repeat
PF13374 (1/1) Tetratricopeptide repeat
PF04055 (1/1) Radical SAM superfamily
PF01656 (1/1) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (1/1) NB-ARC domain

GCF_900221035.1

448.85 +- 500.64

0.02 +- 0.04

PF07690 (5/7) Major Facilitator Superfamily

GCF_000162775.1

388.54 +- 336.20

0.02 +- 0.03

No common domains found

GCF_002317035.1

114.67 +- 57.33

0.06 +- 0.03

TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
PF18130 (1/2) ATP-grasp N-terminal domain
PF17908 (1/2) APAF-1 helical domain
PF13640 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13586 (1/2) Transposase DDE domain
PF13535 (1/2) ATP-grasp domain
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12770 (1/2) CHAT domain
PF07993 (1/2) Male sterility protein
PF07510 (1/2) Protein of unknown function (DUF1524)
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04555 (1/2) Restriction endonuclease XhoI
PF03235 (1/2) Protein of unknown function DUF262
PF01937 (1/2) Protein of unknown function DUF89
PF01609 (1/2) Transposase DDE domain
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00931 (1/2) NB-ARC domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00400 (1/2) WD domain, G-beta repeat
PF00106 (1/2) short chain dehydrogenase

GCF_001687325.1

435.83 +- 549.81

0.04 +- 0.09

No common domains found

GCF_001905845.1

71.89 +- 0.00

0.08 +- 0.13

PF13672 (1/1) Protein phosphatase 2C
PF13519 (1/1) von Willebrand factor type A domain
PF13353 (1/1) 4Fe-4S single cluster domain
PF13309 (1/1) HTH domain
PF12770 (1/1) CHAT domain
PF08808 (1/1) RES domain
PF08348 (1/1) YheO-like PAS domain
PF07724 (1/1) AAA domain (Cdc48 subfamily)
PF00291 (1/1) Pyridoxal-phosphate dependent enzyme
PF00069 (1/1) Protein kinase domain
PF00012 (1/1) Hsp70 protein

GCF_000963515.1

515.55 +- 675.40

0.02 +- 0.03

No common domains found

GCF_002276245.1

299.00 +- 0.00

0.03 +- 0.14

TIGR01554 (1/1) phage major capsid protein, HK97 family
TIGR01543 (1/1) phage prohead protease, HK97 family
TIGR01537 (1/1) phage portal protein, HK97 family
TIGR00621 (1/1) single-stranded DNA-binding protein
PF14594 (1/1) Siphovirus ReqiPepy6 Gp37-like protein
PF12708 (1/1) Pectate lyase superfamily protein
PF12307 (1/1) Protein of unknown function (DUF3631)
PF05709 (1/1) Phage tail protein
PF05065 (1/1) Phage capsid family
PF04860 (1/1) Phage portal protein
PF04586 (1/1) Caudovirus prohead serine protease
PF01844 (1/1) HNH endonuclease
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF00436 (1/1) Single-strand binding protein family

GCF_002946835.1

156.24 +- 122.33

0.05 +- 0.07

TIGR00561 (1/2) NAD(P)(+) transhydrogenase (AB-specific), alpha subunit
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12769 (1/2) 4TM region of pyridine nucleotide transhydrogenase, mitoch
PF05222 (1/2) Alanine dehydrogenase/PNT, N-terminal domain
PF02233 (1/2) NAD(P) transhydrogenase beta subunit
PF02225 (1/2) PA domain
PF01978 (1/2) Sugar-specific transcriptional regulator TrmB
PF01262 (1/2) Alanine dehydrogenase/PNT, C-terminal domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family

GCF_000382745.1

667.87 +- 141.02

0.01 +- 0.01

TIGR01891 (1/2) amidohydrolase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01821 (1/2) 5-aminolevulinic acid synthase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF16884 (1/2) N-terminal domain of oxidoreductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08443 (1/2) RimK-like ATP-grasp domain
PF07690 (1/2) Major Facilitator Superfamily
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00107 (1/2) Zinc-binding dehydrogenase

GCF_003933965.1

326.29 +- 189.71

0.03 +- 0.04

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF14329 (1/2) Domain of unknown function (DUF4386)
PF09339 (1/2) IclR helix-turn-helix domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF02866 (1/2) lactate/malate dehydrogenase, alpha/beta C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02452 (1/2) PemK-like, MazF-like toxin of type II toxin-antitoxin system
PF01614 (1/2) Bacterial transcriptional regulator
PF01476 (1/2) LysM domain
PF01425 (1/2) Amidase
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00561 (1/2) alpha/beta hydrolase fold
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00144 (1/2) Beta-lactamase
PF00056 (1/2) lactate/malate dehydrogenase, NAD binding domain

GCF_000720875.1

547.05 +- 848.21

0.04 +- 0.09

No common domains found

GCF_001700505.1

124.55 +- 0.00

0.03 +- 0.04

PF13581 (1/1) Histidine kinase-like ATPase domain
PF13191 (1/1) AAA ATPase domain
PF09346 (1/1) SMI1 / KNR4 family (SUKH-1)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF00561 (1/1) alpha/beta hydrolase fold
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter

GCF_000497445.1

175.91 +- 0.00

0.02 +- 0.02

PF13377 (1/1) Periplasmic binding protein-like domain
PF08007 (1/1) Cupin superfamily protein
PF02435 (1/1) Levansucrase/Invertase
PF00356 (1/1) Bacterial regulatory proteins, lacI family

GCF_002891865.1

274.03 +- 287.20

0.04 +- 0.04

No common domains found

GCF_000259895.1

130.00 +- 0.00

0.04 +- 0.01

TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13460 (1/1) NAD(P)H-binding
PF07690 (1/1) Major Facilitator Superfamily
PF01814 (1/1) Hemerythrin HHE cation binding domain
PF01494 (1/1) FAD binding domain
PF00561 (1/1) alpha/beta hydrolase fold

GCF_002217715.1

421.38 +- 450.74

0.03 +- 0.04

PF00005 (2/4) ABC transporter

GCF_000719365.1

207.58 +- 38.70

0.03 +- 0.05

No common domains found

GCF_001189035.1

602.00 +- 0.00

0.01 +- 0.01

GCF_900110735.1

129.13 +- 42.47

0.05 +- 0.02

TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
TIGR00345 (1/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (1/2) 5TM C-terminal transporter carbon starvation CstA
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF02812 (1/2) Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF02554 (1/2) Carbon starvation protein CstA
PF02374 (1/2) Anion-transporting ATPase
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region
PF00696 (1/2) Amino acid kinase family
PF00682 (1/2) HMGL-like
PF00501 (1/2) AMP-binding enzyme
PF00326 (1/2) Prolyl oligopeptidase family
PF00208 (1/2) Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
PF00155 (1/2) Aminotransferase class I and II
PF00117 (1/2) Glutamine amidotransferase class-I

GCF_000376565.1

629.20 +- 0.00

0.02 +- 0.01

TIGR02276 (1/1) 40-residue YVTN family beta-propeller repeat
PF13759 (1/1) Putative 2OG-Fe(II) oxygenase
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (1/1) Major Facilitator Superfamily
PF06224 (1/1) Winged helix DNA-binding domain
PF02239 (1/1) Cytochrome D1 heme domain
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_000718615.1

340.92 +- 81.57

0.05 +- 0.16

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF13796 (1/2) Putative sensor
PF13578 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF08659 (1/2) KR domain
PF07730 (1/2) Histidine kinase
PF07179 (1/2) SseB protein N-terminal domain
PF06259 (1/2) Alpha/beta hydrolase
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF03621 (1/2) MbtH-like protein
PF02687 (1/2) FtsX-like permease family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01757 (1/2) Acyltransferase family
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_000743295.1

930.68 +- 1002.30

0.02 +- 0.01

PF00005 (2/3) ABC transporter

GCF_000718625.1

355.33 +- 150.61

0.02 +- 0.05

PF07291 (2/3) Methylamine utilisation protein MauE
PF00717 (2/3) Peptidase S24-like
PF00578 (2/3) AhpC/TSA family
PF00005 (2/3) ABC transporter

GCF_003182455.1

187.39 +- 133.37

0.02 +- 0.01

No common domains found

GCF_001905525.1

223.60 +- 34.40

0.04 +- 0.07

TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (1/2) SnoaL-like domain
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/2) SseB protein N-terminal domain
PF07045 (1/2) Domain of unknown function (DUF1330)
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01738 (1/2) Dienelactone hydrolase family
PF00664 (1/2) ABC transporter transmembrane region
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter

GCF_002005225.1

502.43 +- 0.00

0.03 +- 0.03

GCF_004010275.1

1560.00 +- 0.00

0.01 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
PF00005 (1/1) ABC transporter

GCF_900090085.1

1238.40 +- 0.00

0.01 +- 0.01

GCF_900104865.1

260.45 +- 175.21

0.04 +- 0.14

PF07690 (4/6) Major Facilitator Superfamily

GCF_900177255.1

672.38 +- 761.59

0.03 +- 0.08

No common domains found

GCF_003933295.1

199.99 +- 154.70

0.04 +- 0.07

PF07690 (3/4) Major Facilitator Superfamily

GCF_001280125.1

282.30 +- 219.37

0.04 +- 0.08

PF18556 (1/2) Bacterial Tetracyclin repressor, C-terminal domain
PF17754 (1/2) MftR C-terminal domain
PF13460 (1/2) NAD(P)H-binding
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF01418 (1/2) Helix-turn-helix domain, rpiR family
PF01380 (1/2) SIS domain
PF01266 (1/2) FAD dependent oxidoreductase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (1/2) NUDIX domain

GCF_002551435.1

197.77 +- 128.18

0.07 +- 0.13

PF00005 (2/3) ABC transporter

GCF_000720145.1

387.00 +- 0.00

0.01 +- 0.00

PF17874 (1/1) MalT-like TPR region
PF12770 (1/1) CHAT domain
PF04030 (1/1) D-arabinono-1,4-lactone oxidase
PF01565 (1/1) FAD binding domain
PF00248 (1/1) Aldo/keto reductase family

GCF_003330845.1

126.33 +- 9.33

0.03 +- 0.01

PF16349 (1/2) Domain of unknown function (DUF4978)
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF14100 (1/2) Methane oxygenase PmoA
PF13377 (1/2) Periplasmic binding protein-like domain
PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin
PF12697 (1/2) Alpha/beta hydrolase family
PF11706 (1/2) CGNR zinc finger
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF02894 (1/2) Oxidoreductase family, C-terminal alpha/beta domain
PF02525 (1/2) Flavodoxin-like fold
PF01614 (1/2) Bacterial transcriptional regulator
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00356 (1/2) Bacterial regulatory proteins, lacI family

GCF_000719415.1

1225.38 +- 1932.98

0.03 +- 0.05

No common domains found

GCF_002551305.1

73.71 +- 0.00

0.03 +- 0.02

TIGR03083 (1/1) uncharacterized Actinobacterial protein TIGR03083
PF11716 (1/1) Mycothiol maleylpyruvate isomerase N-terminal domain
PF02627 (1/1) Carboxymuconolactone decarboxylase family

GCF_900091955.1

199.03 +- 84.51

0.04 +- 0.05

No common domains found

GCF_001895105.1

260.00 +- 0.00

0.01 +- 0.00

PF09995 (1/1) Uncharacterized protein conserved in bacteria (DUF2236)
PF00246 (1/1) Zinc carboxypeptidase

GCF_000156435.1

110.12 +- 0.00

0.05 +- 0.09

PF12450 (1/1) von Willebrand factor
PF12034 (1/1) Domain of unknown function (DUF3520)
PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00501 (1/1) AMP-binding enzyme
PF00092 (1/1) von Willebrand factor type A domain
PF00005 (1/1) ABC transporter

GCF_003428925.1

177.38 +- 145.12

0.03 +- 0.02

PF00561 (2/2) alpha/beta hydrolase fold
PF12697 (1/2) Alpha/beta hydrolase family
PF11723 (1/2) Homotrimeric ring hydroxylase
PF08386 (1/2) TAP-like protein
PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00175 (1/2) Oxidoreductase NAD-binding domain
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain

GCF_001751245.1

103.20 +- 0.00

0.02 +- 0.00

PF13302 (1/1) Acetyltransferase (GNAT) domain
PF00156 (1/1) Phosphoribosyl transferase domain

GCF_000349325.1

1012.15 +- 19.85

0.01 +- 0.00

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR03296 (1/2) M6 family metalloprotease domain
PF17920 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08241 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF01980 (1/2) tRNA-methyltransferase O
PF01614 (1/2) Bacterial transcriptional regulator
PF01494 (1/2) FAD binding domain
PF01471 (1/2) Putative peptidoglycan binding domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family

GCF_900107965.1

274.12 +- 112.88

0.02 +- 0.03

TIGR03558 (1/2) luciferase family oxidoreductase, group 1
TIGR02822 (1/2) zinc-binding alcohol dehydrogenase family protein
PF14518 (1/2) Iron-containing redox enzyme
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05630 (1/2) Necrosis inducing protein (NPP1)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04055 (1/2) Radical SAM superfamily
PF03704 (1/2) Bacterial transcriptional activator domain
PF00931 (1/2) NB-ARC domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00296 (1/2) Luciferase-like monooxygenase
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family
PF00069 (1/2) Protein kinase domain

GCF_900105915.1

118.86 +- 0.00

0.03 +- 0.03

PF12833 (1/1) Helix-turn-helix domain
PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00578 (1/1) AhpC/TSA family
PF00005 (1/1) ABC transporter

GCF_900142595.1

1227.17 +- 1178.68

0.01 +- 0.01

PF07690 (2/3) Major Facilitator Superfamily
PF00196 (2/3) Bacterial regulatory proteins, luxR family

GCF_003984785.1

403.88 +- 0.00

0.04 +- 0.03

TIGR01733 (1/1) amino acid adenylation domain
PF16653 (1/1) Saccharopine dehydrogenase C-terminal domain
PF14518 (1/1) Iron-containing redox enzyme
PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF13535 (1/1) ATP-grasp domain
PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09334 (1/1) tRNA synthetases class I (M)
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF05222 (1/1) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (1/1) Saccharopine dehydrogenase NADP binding domain
PF03417 (1/1) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
PF01266 (1/1) FAD dependent oxidoreductase
PF00975 (1/1) Thioesterase domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (1/1) Cytochrome P450

GCF_000377545.1

241.21 +- 170.50

0.07 +- 0.12

No common domains found

GCF_004195885.1

22.94 +- 0.00

0.09 +- 0.06

GCF_000717895.1

169.72 +- 120.26

0.08 +- 0.14

No common domains found

GCF_001279685.1

618.44 +- 542.56

0.03 +- 0.05

TIGR02493 (1/2) pyruvate formate-lyase 1-activating enzyme
TIGR01828 (1/2) pyruvate, phosphate dikinase
TIGR01426 (1/2) glycosyltransferase, MGT family
TIGR01255 (1/2) formate acetyltransferase
PF17914 (1/2) HopA1 effector protein family
PF14325 (1/2) Domain of unknown function (DUF4383)
PF13692 (1/2) Glycosyl transferases group 1
PF13601 (1/2) Winged helix DNA-binding domain
PF13411 (1/2) MerR HTH family regulatory protein
PF12698 (1/2) ABC-2 family transporter protein
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02901 (1/2) Pyruvate formate lyase-like
PF02896 (1/2) PEP-utilising enzyme, TIM barrel domain
PF02607 (1/2) B12 binding domain
PF02441 (1/2) Flavoprotein
PF01636 (1/2) Phosphotransferase enzyme family
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01228 (1/2) Glycine radical
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00582 (1/2) Universal stress protein family
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter

GCF_003144095.1

119.08 +- 0.00

0.02 +- 0.02

PF13560 (1/1) Helix-turn-helix domain
PF00891 (1/1) O-methyltransferase domain
PF00239 (1/1) Resolvase, N terminal domain

GCF_000725885.1

260.00 +- 0.00

0.01 +- 0.00

PF04655 (1/1) Aminoglycoside/hydroxyurea antibiotic resistance kinase

GCF_900112845.1

1316.55 +- 1130.39

0.01 +- 0.01

PF13575 (2/4) Domain of unknown function (DUF4135)
PF00664 (2/4) ABC transporter transmembrane region
PF00005 (2/4) ABC transporter

GCF_002156075.1

100.29 +- 48.29

0.03 +- 0.03

PF17189 (1/2) Glycosyl hydrolase family 30 beta sandwich domain
PF16757 (1/2) Alpha-L-fucosidase C-terminal domain
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13460 (1/2) NAD(P)H-binding
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF02055 (1/2) Glycosyl hydrolase family 30 TIM-barrel domain
PF01120 (1/2) Alpha-L-fucosidase
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00561 (1/2) alpha/beta hydrolase fold

GCF_000404005.1

252.97 +- 0.00

0.09 +- 0.25

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13601 (1/1) Winged helix DNA-binding domain
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12730 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04820 (1/1) Tryptophan halogenase
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_003041235.1

33.33 +- 0.00

0.06 +- 0.09

PF17996 (1/1) Carbohydrate esterase 2 N-terminal
PF17829 (1/1) Gylcosyl hydrolase family 115 C-terminal domain
PF15979 (1/1) Glycosyl hydrolase family 115
PF13472 (1/1) GDSL-like Lipase/Acylhydrolase family
PF13191 (1/1) AAA ATPase domain
PF00067 (1/1) Cytochrome P450

GCF_002217755.1

1093.43 +- 1235.07

0.01 +- 0.02

No common domains found

GCF_000816025.1

159.69 +- 145.38

0.05 +- 0.08

No common domains found

GCF_003949535.1

412.80 +- 0.00

0.01 +- 0.00

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF13546 (1/1) DDE superfamily endonuclease
PF05193 (1/1) Peptidase M16 inactive domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00005 (1/1) ABC transporter

GCF_900116145.1

78.93 +- 17.82

0.06 +- 0.06

TIGR03557 (1/2) F420-dependent oxidoreductase, G6PDH family
TIGR01733 (1/2) amino acid adenylation domain
TIGR01136 (1/2) cysteine synthase
PF14027 (1/2) Questin oxidase-like
PF12833 (1/2) Helix-turn-helix domain
PF11814 (1/2) Peptidase_C39 like family
PF02311 (1/2) AraC-like ligand binding domain
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00975 (1/2) Thioesterase domain
PF00892 (1/2) EamA-like transporter family
PF00550 (1/2) Phosphopantetheine attachment site
PF00532 (1/2) Periplasmic binding proteins and sugar binding domain of LacI family
PF00501 (1/2) AMP-binding enzyme
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00296 (1/2) Luciferase-like monooxygenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter

GCF_000720405.1

321.58 +- 61.58

0.02 +- 0.01

TIGR00229 (1/2) PAS domain S-box protein
PF08448 (1/2) PAS fold
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04055 (1/2) Radical SAM superfamily
PF03466 (1/2) LysR substrate binding domain
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF02310 (1/2) B12 binding domain
PF01590 (1/2) GAF domain
PF01494 (1/2) FAD binding domain
PF00733 (1/2) Asparagine synthase
PF00501 (1/2) AMP-binding enzyme
PF00455 (1/2) DeoR C terminal sensor domain
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00069 (1/2) Protein kinase domain

GCF_000720535.1

109.97 +- 12.47

0.06 +- 0.04

GCF_004127445.1

422.83 +- 255.32

0.03 +- 0.11

PF07690 (3/4) Major Facilitator Superfamily
PF04055 (2/4) Radical SAM superfamily
PF02310 (2/4) B12 binding domain
PF00326 (2/4) Prolyl oligopeptidase family

GCF_003121295.1

235.10 +- 135.05

0.03 +- 0.09

No common domains found

GCF_000938975.1

440.14 +- 205.13

0.04 +- 0.09

No common domains found

GCF_000725745.1

348.73 +- 213.99

0.05 +- 0.12

No common domains found

GCF_000242715.1

346.16 +- 55.91

0.06 +- 0.22

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01746 (1/2) thioester reductase domain
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10901 (1/2) Protein of unknown function (DUF2690)
PF08443 (1/2) RimK-like ATP-grasp domain
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter

GCF_000718305.1

211.04 +- 104.96

0.06 +- 0.16

No common domains found

GCF_003248355.1

732.61 +- 344.29

0.02 +- 0.02

PF07690 (4/5) Major Facilitator Superfamily

GCF_000718635.1

1058.57 +- 583.30

0.01 +- 0.00

PF00550 (2/4) Phosphopantetheine attachment site
PF00005 (2/4) ABC transporter

GCF_000253235.1

269.79 +- 233.27

0.03 +- 0.11

No common domains found

GCF_000154885.1

288.99 +- 200.93

0.05 +- 0.07

PF07690 (2/2) Major Facilitator Superfamily
TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating)
TIGR00566 (1/2) glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase
TIGR00553 (1/2) aminodeoxychorismate synthase, component I
PF13622 (1/2) Thioesterase-like superfamily
PF13621 (1/2) Cupin-like domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12146 (1/2) Serine aminopeptidase, S33
PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF08031 (1/2) Berberine and berberine like
PF07836 (1/2) DmpG-like communication domain
PF04715 (1/2) Anthranilate synthase component I, N terminal region
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01565 (1/2) FAD binding domain
PF01494 (1/2) FAD binding domain
PF01474 (1/2) Class-II DAHP synthetase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01063 (1/2) Amino-transferase class IV
PF00682 (1/2) HMGL-like
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00425 (1/2) chorismate binding enzyme
PF00301 (1/2) Rubredoxin
PF00171 (1/2) Aldehyde dehydrogenase family
PF00155 (1/2) Aminotransferase class I and II
PF00117 (1/2) Glutamine amidotransferase class-I
PF00067 (1/2) Cytochrome P450

GCF_003048205.2

218.08 +- 48.86

0.04 +- 0.13

PF07690 (2/3) Major Facilitator Superfamily

GCF_000373525.1

645.36 +- 394.64

0.03 +- 0.03

TIGR03396 (1/2) phospholipase C, phosphocholine-specific
TIGR01258 (1/2) phosphoglycerate mutase 1 family
TIGR01060 (1/2) phosphopyruvate hydratase
PF11575 (1/2) FhuF 2Fe-2S C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF05506 (1/2) Domain of unknown function (DUF756)
PF04185 (1/2) Phosphoesterase family
PF04055 (1/2) Radical SAM superfamily
PF03965 (1/2) Penicillinase repressor
PF03952 (1/2) Enolase, N-terminal domain
PF03453 (1/2) MoeA N-terminal region (domain I and II)
PF02441 (1/2) Flavoprotein
PF01712 (1/2) Deoxynucleoside kinase
PF01435 (1/2) Peptidase family M48
PF00994 (1/2) Probable molybdopterin binding domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00293 (1/2) NUDIX domain
PF00113 (1/2) Enolase, C-terminal TIM barrel domain

GCF_003687505.1

341.57 +- 113.49

0.02 +- 0.05

No common domains found

GCF_002920615.1

559.00 +- 481.00

0.02 +- 0.03

PF07690 (2/2) Major Facilitator Superfamily
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF17676 (1/2) LD-carboxypeptidase C-terminal domain
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13460 (1/2) NAD(P)H-binding
PF13393 (1/2) Histidyl-tRNA synthetase
PF07859 (1/2) alpha/beta hydrolase fold
PF02016 (1/2) LD-carboxypeptidase N-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00152 (1/2) tRNA synthetases class II (D, K and N)
PF00067 (1/2) Cytochrome P450

GCF_000717285.1

71.86 +- 41.63

0.08 +- 0.08

No common domains found

GCF_004195995.1

44.48 +- 0.00

0.04 +- 0.03

GCF_000009765.2

191.74 +- 10.48

0.07 +- 0.10

PF07690 (2/2) Major Facilitator Superfamily
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF14224 (1/2) Domain of unknown function (DUF4331)
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF02882 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00925 (1/2) GTP cyclohydrolase II
PF00763 (1/2) Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
PF00743 (1/2) Flavin-binding monooxygenase-like
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00348 (1/2) Polyprenyl synthetase
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase
PF00082 (1/2) Subtilase family

GCF_000964305.1

117.96 +- 12.04

0.06 +- 0.09

TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01891 (1/2) amidohydrolase
PF13738 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF13091 (1/2) PLD-like domain
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF09084 (1/2) NMT1/THI5 like
PF06267 (1/2) Family of unknown function (DUF1028)
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF03466 (1/2) LysR substrate binding domain
PF02386 (1/2) Cation transport protein
PF02254 (1/2) TrkA-N domain
PF02080 (1/2) TrkA-C domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01042 (1/2) Endoribonuclease L-PSP
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00296 (1/2) Luciferase-like monooxygenase
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00083 (1/2) Sugar (and other) transporter
PF00005 (1/2) ABC transporter

GCF_000718675.1

47.24 +- 3.02

0.09 +- 0.08

GCF_000935125.1

1350.92 +- 1370.79

0.01 +- 0.00

No common domains found

GCF_001279905.1

1935.00 +- 0.00

0.01 +- 0.00

GCF_000156455.1

668.57 +- 0.00

0.03 +- 0.01

GCF_002891315.1

460.58 +- 358.07

0.03 +- 0.04

No common domains found

GCF_000240165.1

228.93 +- 0.00

0.08 +- 0.26

TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00976 (1/1) hydrolase CocE/NonD family protein
TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16911 (1/1) Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus
PF13581 (1/1) Histidine kinase-like ATPase domain
PF12911 (1/1) N-terminal TM domain of oligopeptide transport permease C
PF09339 (1/1) IclR helix-turn-helix domain
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF07690 (1/1) Major Facilitator Superfamily
PF03328 (1/1) HpcH/HpaI aldolase/citrate lyase family
PF02515 (1/1) CoA-transferase family III
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF01614 (1/1) Bacterial transcriptional regulator
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter

GCF_002188335.1

561.83 +- 388.08

0.04 +- 0.12

PF00682 (2/2) HMGL-like
PF00180 (2/2) Isocitrate/isopropylmalate dehydrogenase
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR00710 (1/2) drug resistance transporter, Bcr/CflA subfamily
TIGR00171 (1/2) 3-isopropylmalate dehydratase, small subunit
TIGR00170 (1/2) 3-isopropylmalate dehydratase, large subunit
TIGR00169 (1/2) 3-isopropylmalate dehydrogenase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF11806 (1/2) Domain of unknown function (DUF3327)
PF08242 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF03737 (1/2) Aldolase/RraA
PF03621 (1/2) MbtH-like protein
PF03466 (1/2) LysR substrate binding domain
PF01361 (1/2) Tautomerase enzyme
PF00994 (1/2) Probable molybdopterin binding domain
PF00756 (1/2) Putative esterase
PF00694 (1/2) Aconitase C-terminal domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00330 (1/2) Aconitase family (aconitate hydratase)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

GCF_002155725.1

423.30 +- 226.81

0.02 +- 0.02

PF00561 (2/3) alpha/beta hydrolase fold

GCF_003688995.1

780.73 +- 530.82

0.03 +- 0.10

PF08402 (3/5) TOBE domain
PF00528 (3/5) Binding-protein-dependent transport system inner membrane component
PF00005 (3/5) ABC transporter

GCF_001746455.1

1197.28 +- 1112.33

0.03 +- 0.05

TIGR02965 (1/2) xanthine dehydrogenase, molybdopterin binding subunit
TIGR02964 (1/2) xanthine dehydrogenase accessory protein XdhC
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13478 (1/2) XdhC Rossmann domain
PF13458 (1/2) Periplasmic binding protein
PF13367 (1/2) PrsW family intramembrane metalloprotease
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02625 (1/2) XdhC and CoxI family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01425 (1/2) Amidase
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01070 (1/2) FMN-dependent dehydrogenase
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00756 (1/2) Putative esterase
PF00682 (1/2) HMGL-like
PF00557 (1/2) Metallopeptidase family M24
PF00384 (1/2) Molybdopterin oxidoreductase
PF00248 (1/2) Aldo/keto reductase family
PF00155 (1/2) Aminotransferase class I and II
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/2) ABC transporter

GCF_002300165.1

46.36 +- 0.83

0.06 +- 0.11

TIGR04269 (1/2) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (1/2) FXSXX-COOH protein
TIGR04267 (1/2) HEXXH motif domain
TIGR02983 (1/2) RNA polymerase sigma-70 factor, sigma-E family
PF17964 (1/2) Bacterial Ig domain
PF14864 (1/2) Alkyl sulfatase C-terminal
PF14863 (1/2) Alkyl sulfatase dimerisation
PF13676 (1/2) TIR domain
PF13424 (1/2) Tetratricopeptide repeat
PF13374 (1/2) Tetratricopeptide repeat
PF13365 (1/2) Trypsin-like peptidase domain
PF12680 (1/2) SnoaL-like domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04055 (1/2) Radical SAM superfamily
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF01361 (1/2) Tautomerase enzyme
PF00931 (1/2) NB-ARC domain
PF00912 (1/2) Transglycosylase
PF00753 (1/2) Metallo-beta-lactamase superfamily

GCF_001905445.1

617.78 +- 387.08

0.04 +- 0.03

TIGR03217 (1/2) 4-hydroxy-2-oxovalerate aldolase
TIGR03215 (1/2) acetaldehyde dehydrogenase (acetylating)
PF17874 (1/2) MalT-like TPR region
PF13621 (1/2) Cupin-like domain
PF13560 (1/2) Helix-turn-helix domain
PF13393 (1/2) Histidyl-tRNA synthetase
PF13191 (1/2) AAA ATPase domain
PF09290 (1/2) Prokaryotic acetaldehyde dehydrogenase, dimerisation
PF07836 (1/2) DmpG-like communication domain
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01061 (1/2) ABC-2 type transporter
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00682 (1/2) HMGL-like
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00155 (1/2) Aminotransferase class I and II
PF00005 (1/2) ABC transporter

GCF_000935135.2

212.13 +- 239.29

0.04 +- 0.03

No common domains found

GCF_001650215.1

179.24 +- 103.00

0.05 +- 0.08

No common domains found

GCF_003265665.1

2797.24 +- 0.00

0.02 +- 0.01

GCF_001748085.1

855.53 +- 692.47

0.07 +- 0.21

PF13377 (1/2) Periplasmic binding protein-like domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF13183 (1/2) 4Fe-4S dicluster domain
PF12697 (1/2) Alpha/beta hydrolase family
PF09339 (1/2) IclR helix-turn-helix domain
PF07090 (1/2) Putative glutamine amidotransferase
PF04072 (1/2) Leucine carboxyl methyltransferase
PF03069 (1/2) Acetamidase/Formamidase family
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02754 (1/2) Cysteine-rich domain
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02608 (1/2) ABC transporter substrate-binding protein PnrA-like
PF02515 (1/2) CoA-transferase family III
PF01614 (1/2) Bacterial transcriptional regulator
PF01565 (1/2) FAD binding domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01156 (1/2) Inosine-uridine preferring nucleoside hydrolase
PF01144 (1/2) Coenzyme A transferase
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter

GCF_000720885.1

43.00 +- 0.00

0.07 +- 0.10

GCF_000745345.1

258.00 +- 0.00

0.01 +- 0.00

PF14015 (1/1) Protein of unknown function (DUF4231)
PF08244 (1/1) Glycosyl hydrolases family 32 C terminal
PF04314 (1/1) Copper chaperone PCu(A)C
PF01674 (1/1) Lipase (class 2)
PF01435 (1/1) Peptidase family M48
PF00251 (1/1) Glycosyl hydrolases family 32 N-terminal domain

GCF_900091765.1

376.34 +- 93.94

0.04 +- 0.01

TIGR03561 (1/2) peroxiredoxin, Ohr subfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13649 (1/2) Methyltransferase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/2) IclR helix-turn-helix domain
PF09084 (1/2) NMT1/THI5 like
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF04199 (1/2) Putative cyclase
PF03972 (1/2) MmgE/PrpD family
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF02566 (1/2) OsmC-like protein
PF02515 (1/2) CoA-transferase family III
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/2) Phosphotriesterase family
PF01979 (1/2) Amidohydrolase family
PF01614 (1/2) Bacterial transcriptional regulator
PF01546 (1/2) Peptidase family M20/M25/M40
PF01494 (1/2) FAD binding domain
PF00884 (1/2) Sulfatase
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter

GCF_000720395.1

404.44 +- 0.00

0.02 +- 0.01

GCF_000720115.1

2655.62 +- 2375.38

0.01 +- 0.01

PF17914 (1/2) HopA1 effector protein family
PF16859 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13732 (1/2) Domain of unknown function (DUF4162)
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12802 (1/2) MarR family
PF12698 (1/2) ABC-2 family transporter protein
PF07690 (1/2) Major Facilitator Superfamily
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF05193 (1/2) Peptidase M16 inactive domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02441 (1/2) Flavoprotein
PF02225 (1/2) PA domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00501 (1/2) AMP-binding enzyme
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00082 (1/2) Subtilase family
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_000372745.1

344.33 +- 273.07

0.06 +- 0.22

No common domains found

GCF_002224125.1

241.32 +- 123.64

0.03 +- 0.06

No common domains found

GCF_000716675.1

197.29 +- 60.71

0.02 +- 0.03

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
TIGR01733 (1/2) amino acid adenylation domain
TIGR01297 (1/2) cation diffusion facilitator family transporter
PF12680 (1/2) SnoaL-like domain
PF08242 (1/2) Methyltransferase domain
PF07883 (1/2) Cupin domain
PF02031 (1/2) Streptomyces extracellular neutral proteinase (M7) family
PF01695 (1/2) IstB-like ATP binding protein
PF01545 (1/2) Cation efflux family
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00665 (1/2) Integrase core domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00221 (1/2) Aromatic amino acid lyase

GCF_001419745.1

50.17 +- 7.17

0.05 +- 0.05

PF17874 (1/2) MalT-like TPR region
PF14534 (1/2) Domain of unknown function (DUF4440)
PF13560 (1/2) Helix-turn-helix domain
PF13432 (1/2) Tetratricopeptide repeat
PF12697 (1/2) Alpha/beta hydrolase family
PF08002 (1/2) Protein of unknown function (DUF1697)
PF07063 (1/2) Domain of unknown function (DUF1338)
PF05922 (1/2) Peptidase inhibitor I9
PF01323 (1/2) DSBA-like thioredoxin domain
PF01266 (1/2) FAD dependent oxidoreductase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00082 (1/2) Subtilase family

GCF_000177195.2

360.86 +- 245.80

0.04 +- 0.06

GCF_001905905.1

22.03 +- 0.00

0.09 +- 0.19

TIGR03638 (1/1) CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI
TIGR02548 (1/1) CRISPR type I-E/ECOLI-associated protein CasB/Cse2
TIGR02547 (1/1) CRISPR type I-E/ECOLI-associated protein CasA/Cse1
TIGR01907 (1/1) CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
TIGR01873 (1/1) CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI
TIGR01869 (1/1) CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
TIGR01868 (1/1) CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI
TIGR01596 (1/1) CRISPR-associated endonuclease Cas3-HD
TIGR01587 (1/1) CRISPR-associated helicase Cas3
PF18395 (1/1) Cas3 C-terminal domain
PF18019 (1/1) HD domain
PF09707 (1/1) CRISPR-associated protein (Cas_Cas2CT1978)
PF09704 (1/1) CRISPR-associated protein (Cas_Cas5)
PF09485 (1/1) CRISPR-associated protein Cse2 (CRISPR_cse2)
PF09481 (1/1) CRISPR-associated protein Cse1 (CRISPR_cse1)
PF09344 (1/1) CT1975-like protein
PF08798 (1/1) CRISPR associated protein
PF07876 (1/1) Stress responsive A/B Barrel Domain
PF05685 (1/1) Putative restriction endonuclease

GCF_900091745.1

301.05 +- 23.95

0.02 +- 0.02

GCF_004187715.1

471.39 +- 439.62

0.05 +- 0.14

PF00005 (2/3) ABC transporter

GCF_000968255.1

304.63 +- 206.48

0.03 +- 0.05

PF07690 (3/4) Major Facilitator Superfamily

GCF_003851625.1

1350.51 +- 1605.33

0.02 +- 0.03

PF00005 (2/3) ABC transporter

GCF_000772895.1

30.35 +- 0.00

0.07 +- 0.03

PF00069 (1/1) Protein kinase domain

GCF_002705685.1

2080.00 +- 0.00

0.01 +- 0.00

GCF_002907485.1

455.00 +- 0.00

0.05 +- 0.02

TIGR00976 (1/1) hydrolase CocE/NonD family protein
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF12697 (1/1) Alpha/beta hydrolase family
PF12679 (1/1) ABC-2 family transporter protein
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF04909 (1/1) Amidohydrolase
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (1/1) Coenzyme A transferase
PF00501 (1/1) AMP-binding enzyme
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/1) short chain dehydrogenase
PF00005 (1/1) ABC transporter

GCF_003324565.1

207.63 +- 180.71

0.04 +- 0.05

PF00583 (2/4) Acetyltransferase (GNAT) family

GCF_001866675.1

830.34 +- 623.33

0.05 +- 0.13

PF07690 (2/3) Major Facilitator Superfamily

GCF_000373565.1

156.00 +- 0.00

0.01 +- 0.01

PF17103 (1/1) Stealth protein CR4, conserved region 4
PF17102 (1/1) Stealth protein CR3, conserved region 3
PF17101 (1/1) Stealth protein CR1, conserved region 1
PF13091 (1/1) PLD-like domain
PF11380 (1/1) Stealth protein CR2, conserved region 2
PF07859 (1/1) alpha/beta hydrolase fold

GCF_000745675.1

291.95 +- 313.08

0.03 +- 0.11

No common domains found

GCF_000158895.1

365.53 +- 162.02

0.02 +- 0.02

PF07690 (2/3) Major Facilitator Superfamily

GCF_001531145.1

37.22 +- 2.82

0.07 +- 0.13

TIGR03707 (1/2) polyphosphate kinase 2
PF12802 (1/2) MarR family
PF11239 (1/2) Protein of unknown function (DUF3040)
PF04231 (1/2) Endonuclease I
PF03976 (1/2) Polyphosphate kinase 2 (PPK2)
PF03301 (1/2) Tryptophan 2,3-dioxygenase
PF01425 (1/2) Amidase

GCF_000716025.1

228.40 +- 239.32

0.06 +- 0.07

No common domains found

GCF_900091775.1

221.11 +- 182.02

0.06 +- 0.04

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF16656 (1/2) Purple acid Phosphatase, N-terminal domain
PF13795 (1/2) HupE / UreJ protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF12146 (1/2) Serine aminopeptidase, S33
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF06030 (1/2) Bacterial protein of unknown function (DUF916)
PF04909 (1/2) Amidohydrolase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (1/2) Coenzyme A transferase
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00149 (1/2) Calcineurin-like phosphoesterase
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter

GCF_000482585.1

644.20 +- 346.40

0.04 +- 0.17

PF00528 (2/3) Binding-protein-dependent transport system inner membrane component
PF00005 (2/3) ABC transporter

GCF_000718985.1

423.08 +- 21.75

0.02 +- 0.03

TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF13459 (1/2) 4Fe-4S single cluster domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07729 (1/2) FCD domain
PF07722 (1/2) Peptidase C26
PF03466 (1/2) LysR substrate binding domain
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00501 (1/2) AMP-binding enzyme
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family
PF00120 (1/2) Glutamine synthetase, catalytic domain
PF00067 (1/2) Cytochrome P450

GCF_001270565.1

258.72 +- 14.97

0.06 +- 0.16

GCF_001646665.1

57.33 +- 0.00

0.05 +- 0.07

PF07690 (1/1) Major Facilitator Superfamily
PF03621 (1/1) MbtH-like protein
PF01019 (1/1) Gamma-glutamyltranspeptidase
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

GCF_900129855.1

291.86 +- 377.70

0.04 +- 0.06

No common domains found

GCF_001418545.1

62.40 +- 0.00

0.05 +- 0.07

GCF_000373225.1

422.68 +- 0.00

0.07 +- 0.08

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13191 (1/1) AAA ATPase domain
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter

GCF_001049855.1

263.86 +- 198.86

0.04 +- 0.03

TIGR00843 (1/2) benzoate transporter
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF13535 (1/2) ATP-grasp domain
PF12833 (1/2) Helix-turn-helix domain
PF10994 (1/2) Protein of unknown function (DUF2817)
PF07690 (1/2) Major Facilitator Superfamily
PF03594 (1/2) Benzoate membrane transport protein
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01925 (1/2) Sulfite exporter TauE/SafE
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01070 (1/2) FMN-dependent dehydrogenase
PF00696 (1/2) Amino acid kinase family
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00155 (1/2) Aminotransferase class I and II

GCF_000721665.1

112.10 +- 53.96

0.04 +- 0.05

No common domains found

GCF_002154505.1

125.71 +- 40.75

0.03 +- 0.04

No common domains found

GCF_003248335.1

691.82 +- 241.84

0.01 +- 0.01

PF07690 (3/4) Major Facilitator Superfamily
PF02668 (2/4) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (2/4) B12 binding domain

GCF_003384865.1

260.00 +- 0.00

0.02 +- 0.02

PF13365 (1/1) Trypsin-like peptidase domain
PF00400 (1/1) WD domain, G-beta repeat
PF00248 (1/1) Aldo/keto reductase family

GCF_000718945.1

127.31 +- 62.83

0.04 +- 0.08

No common domains found

GCF_000725465.1

94.55 +- 0.00

0.02 +- 0.01

PF04073 (1/1) Aminoacyl-tRNA editing domain
PF01116 (1/1) Fructose-bisphosphate aldolase class-II
PF00892 (1/1) EamA-like transporter family
PF00464 (1/1) Serine hydroxymethyltransferase

GCF_000721085.1

44.23 +- 0.00

0.07 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_002705695.1

157.05 +- 94.21

0.04 +- 0.02

PF07690 (2/3) Major Facilitator Superfamily

GCF_000961885.1

45.27 +- 2.61

0.06 +- 0.07

No common domains found

GCF_001419795.1

32.50 +- 0.00

0.06 +- 0.05

PF13602 (1/1) Zinc-binding dehydrogenase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF00106 (1/1) short chain dehydrogenase

GCF_000932225.2

558.52 +- 221.48

0.03 +- 0.02

PF00005 (2/2) ABC transporter
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04672 (1/2) S-adenosyl methyltransferase
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00296 (1/2) Luciferase-like monooxygenase
PF00069 (1/2) Protein kinase domain

GCF_000497425.1

1917.50 +- 942.50

0.01 +- 0.00

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF08402 (1/2) TOBE domain
PF08241 (1/2) Methyltransferase domain
PF07993 (1/2) Male sterility protein
PF03364 (1/2) Polyketide cyclase / dehydrase and lipid transport
PF03176 (1/2) MMPL family
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01575 (1/2) MaoC like domain
PF00962 (1/2) Adenosine/AMP deaminase
PF00881 (1/2) Nitroreductase family
PF00698 (1/2) Acyl transferase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter

GCF_002943895.1

247.33 +- 247.25

0.05 +- 0.16

No common domains found

GCF_000717105.1

582.45 +- 191.55

0.01 +- 0.01

TIGR01558 (1/2) putative phage terminase, small subunit, P27 family
TIGR01554 (1/2) phage major capsid protein, HK97 family
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR01537 (1/2) phage portal protein, HK97 family
PF14594 (1/2) Siphovirus ReqiPepy6 Gp37-like protein
PF10145 (1/2) Phage-related minor tail protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF05119 (1/2) Phage terminase, small subunit
PF05065 (1/2) Phage capsid family
PF04860 (1/2) Phage portal protein
PF04851 (1/2) Type III restriction enzyme, res subunit
PF04672 (1/2) S-adenosyl methyltransferase
PF04586 (1/2) Caudovirus prohead serine protease
PF04542 (1/2) Sigma-70 region 2
PF03354 (1/2) Phage Terminase
PF01844 (1/2) HNH endonuclease
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01391 (1/2) Collagen triple helix repeat (20 copies)
PF01381 (1/2) Helix-turn-helix
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00271 (1/2) Helicase conserved C-terminal domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_000010605.1

77.40 +- 0.00

0.05 +- 0.05

PF14103 (1/1) Domain of unknown function (DUF4276)
PF13304 (1/1) AAA domain, putative AbiEii toxin, Type IV TA system
PF04101 (1/1) Glycosyltransferase family 28 C-terminal domain
PF03033 (1/1) Glycosyltransferase family 28 N-terminal domain
PF02463 (1/1) RecF/RecN/SMC N terminal domain

GCF_003330865.1

308.79 +- 212.61

0.04 +- 0.13

No common domains found

GCF_000719815.1

383.45 +- 132.55

0.05 +- 0.04

TIGR04364 (1/2) methyltransferase, FxLD system
TIGR04363 (1/2) FxLD family lantipeptide
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13671 (1/2) AAA domain
PF13560 (1/2) Helix-turn-helix domain
PF11723 (1/2) Homotrimeric ring hydroxylase
PF05331 (1/2) Protein of unknown function (DUF742)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03972 (1/2) MmgE/PrpD family
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02900 (1/2) Catalytic LigB subunit of aromatic ring-opening dioxygenase
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01590 (1/2) GAF domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01427 (1/2) D-ala-D-ala dipeptidase
PF01327 (1/2) Polypeptide deformylase
PF01135 (1/2) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (1/2) Glycosyl hydrolases family 15
PF00561 (1/2) alpha/beta hydrolase fold
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00293 (1/2) NUDIX domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00111 (1/2) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/2) ABC transporter

GCF_001418505.1

344.00 +- 0.00

0.01 +- 0.01

PF14759 (1/1) Reductase C-terminal
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/1) Major Facilitator Superfamily
PF04237 (1/1) YjbR
PF00067 (1/1) Cytochrome P450

GCF_000719475.1

212.72 +- 96.88

0.07 +- 0.10

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01525 (1/2) heavy metal translocating P-type ATPase
PF17197 (1/2) Domain of unknown function (DUF5134)
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF08281 (1/2) Sigma-70, region 4
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF03929 (1/2) PepSY-associated TM region
PF03551 (1/2) Transcriptional regulator PadR-like family
PF03412 (1/2) Peptidase C39 family
PF01965 (1/2) DJ-1/PfpI family
PF01569 (1/2) PAP2 superfamily
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00403 (1/2) Heavy-metal-associated domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter

GCF_000968685.2

268.67 +- 34.67

0.05 +- 0.07

TIGR00976 (2/2) hydrolase CocE/NonD family protein
PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF08530 (2/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (2/2) Major Facilitator Superfamily
PF02129 (2/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00501 (2/2) AMP-binding enzyme
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
PF13378 (1/2) Enolase C-terminal domain-like
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01425 (1/2) Amidase
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF01230 (1/2) HIT domain
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00497 (1/2) Bacterial extracellular solute-binding proteins, family 3
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_900105235.1

110.58 +- 75.13

0.05 +- 0.06

PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05331 (1/2) Protein of unknown function (DUF742)
PF04149 (1/2) Domain of unknown function (DUF397)
PF03713 (1/2) Domain of unknown function (DUF305)
PF03259 (1/2) Roadblock/LC7 domain
PF03029 (1/2) Conserved hypothetical ATP binding protein
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00067 (1/2) Cytochrome P450

GCF_900091975.1

276.98 +- 327.62

0.05 +- 0.09

PF07690 (3/4) Major Facilitator Superfamily
PF08281 (2/4) Sigma-70, region 4
PF04542 (2/4) Sigma-70 region 2

GCF_001969965.1

393.32 +- 173.95

0.03 +- 0.04

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR01534 (1/2) glyceraldehyde-3-phosphate dehydrogenase, type I
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13450 (1/2) NAD(P)-binding Rossmann-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03936 (1/2) Terpene synthase family, metal binding domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF03412 (1/2) Peptidase C39 family
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02800 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF00664 (1/2) ABC transporter transmembrane region
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00348 (1/2) Polyprenyl synthetase
PF00106 (1/2) short chain dehydrogenase
PF00067 (1/2) Cytochrome P450
PF00044 (1/2) Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
PF00005 (1/2) ABC transporter

GCF_001723075.1

967.50 +- 0.00

0.01 +- 0.00

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF08402 (1/1) TOBE domain
PF00962 (1/1) Adenosine/AMP deaminase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter

GCF_001746475.1

471.89 +- 410.47

0.05 +- 0.14

GCF_002754595.1

3405.60 +- 0.00

0.01 +- 0.01

TIGR01263 (1/1) 4-hydroxyphenylpyruvate dioxygenase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF14696 (1/1) Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
PF13535 (1/1) ATP-grasp domain
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02153 (1/1) Prephenate dehydrogenase
PF01613 (1/1) Flavin reductase like domain
PF01070 (1/1) FMN-dependent dehydrogenase
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00296 (1/1) Luciferase-like monooxygenase
PF00155 (1/1) Aminotransferase class I and II
PF00106 (1/1) short chain dehydrogenase

GCF_001642995.1

260.90 +- 42.29

0.05 +- 0.07

No common domains found

GCF_001905425.1

581.24 +- 685.62

0.03 +- 0.03

No common domains found

GCF_000154945.1

425.45 +- 0.00

0.04 +- 0.02

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF02774 (1/1) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_002844215.1

451.50 +- 193.50

0.01 +- 0.00

GCF_000154965.1

367.58 +- 597.28

0.05 +- 0.10

No common domains found

GCF_001011035.1

611.99 +- 391.33

0.01 +- 0.01

No common domains found

GCF_000176115.2

485.33 +- 0.00

0.01 +- 0.00

GCF_001270485.1

367.21 +- 79.01

0.02 +- 0.01

No common domains found

GCF_000721305.1

358.89 +- 216.13

0.02 +- 0.02

No common domains found

GCF_001282115.1

838.50 +- 709.50

0.01 +- 0.00

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08007 (1/2) Cupin superfamily protein
PF03412 (1/2) Peptidase C39 family
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01464 (1/2) Transglycosylase SLT domain
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00005 (1/2) ABC transporter

GCF_003259575.1

216.34 +- 127.66

0.05 +- 0.09

GCF_000377965.1

258.00 +- 0.00

0.04 +- 0.02

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_000725475.1

490.71 +- 218.20

0.01 +- 0.02

No common domains found

GCF_002797655.1

285.81 +- 215.38

0.05 +- 0.10

PF13416 (2/4) Bacterial extracellular solute-binding protein
PF00528 (2/4) Binding-protein-dependent transport system inner membrane component

GCF_001509475.1

227.69 +- 209.03

0.03 +- 0.04

No common domains found

GCF_000203835.1

264.81 +- 0.00

0.04 +- 0.03

GCF_000373305.1

637.54 +- 0.00

0.07 +- 0.22

TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR01356 (1/1) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/1) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF18130 (1/1) ATP-grasp N-terminal domain
PF13549 (1/1) ATP-grasp domain
PF13535 (1/1) ATP-grasp domain
PF13480 (1/1) Acetyltransferase (GNAT) domain
PF13115 (1/1) YtkA-like
PF04389 (1/1) Peptidase family M28
PF02627 (1/1) Carboxymuconolactone decarboxylase family
PF01676 (1/1) Metalloenzyme superfamily
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00664 (1/1) ABC transporter transmembrane region
PF00403 (1/1) Heavy-metal-associated domain
PF00275 (1/1) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/1) Aminotransferase class I and II
PF00122 (1/1) E1-E2 ATPase
PF00117 (1/1) Glutamine amidotransferase class-I
PF00005 (1/1) ABC transporter

GCF_001746485.1

2157.83 +- 1185.02

0.03 +- 0.14

GCF_000720175.1

173.58 +- 93.70

0.03 +- 0.04

No common domains found

GCF_004217635.1

380.36 +- 133.98

0.02 +- 0.02

No common domains found

GCF_002803075.1

24.76 +- 0.00

0.08 +- 0.07

PF13602 (1/1) Zinc-binding dehydrogenase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF01522 (1/1) Polysaccharide deacetylase

GCF_001482415.1

268.75 +- 168.50

0.04 +- 0.14

PF04055 (2/3) Radical SAM superfamily

GCF_001625365.1

258.31 +- 187.40

0.03 +- 0.04

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF08877 (1/2) MepB protein
PF08453 (1/2) Peptidase family M9 N-terminal
PF07690 (1/2) Major Facilitator Superfamily
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01764 (1/2) Lipase (class 3)
PF01752 (1/2) Collagenase
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00326 (1/2) Prolyl oligopeptidase family
PF00067 (1/2) Cytochrome P450

GCF_001514285.1

294.16 +- 248.47

0.03 +- 0.05

PF00196 (2/3) Bacterial regulatory proteins, luxR family
PF00004 (2/3) ATPase family associated with various cellular activities (AAA)

GCF_900110755.1

237.08 +- 134.92

0.08 +- 0.23

No common domains found

GCF_000280865.1

200.37 +- 37.42

0.06 +- 0.20

PF07690 (2/2) Major Facilitator Superfamily
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
TIGR00229 (1/2) PAS domain S-box protein
TIGR00178 (1/2) isocitrate dehydrogenase, NADP-dependent
PF13632 (1/2) Glycosyl transferase family group 2
PF13426 (1/2) PAS domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13191 (1/2) AAA ATPase domain
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF08448 (1/2) PAS fold
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF04321 (1/2) RmlD substrate binding domain
PF04055 (1/2) Radical SAM superfamily
PF03971 (1/2) Monomeric isocitrate dehydrogenase
PF02310 (1/2) B12 binding domain
PF01979 (1/2) Amidohydrolase family
PF01590 (1/2) GAF domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00535 (1/2) Glycosyl transferase family 2
PF00480 (1/2) ROK family
PF00459 (1/2) Inositol monophosphatase family
PF00326 (1/2) Prolyl oligopeptidase family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_003984905.1

356.43 +- 276.61

0.04 +- 0.04

PF01425 (2/2) Amidase
TIGR00928 (1/2) adenylosuccinate lyase
TIGR00711 (1/2) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF13673 (1/2) Acetyltransferase (GNAT) domain
PF13460 (1/2) NAD(P)H-binding
PF12800 (1/2) 4Fe-4S binding domain
PF07690 (1/2) Major Facilitator Superfamily
PF07681 (1/2) DoxX
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01494 (1/2) FAD binding domain
PF01427 (1/2) D-ala-D-ala dipeptidase
PF00561 (1/2) alpha/beta hydrolase fold
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00293 (1/2) NUDIX domain
PF00206 (1/2) Lyase
PF00120 (1/2) Glutamine synthetase, catalytic domain
PF00072 (1/2) Response regulator receiver domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_001279655.1

1117.74 +- 1791.14

0.02 +- 0.01

No common domains found

GCF_001553475.1

169.85 +- 112.75

0.04 +- 0.04

No common domains found

GCF_003671685.1

516.00 +- 0.00

0.02 +- 0.01

PF13631 (1/1) Cytochrome b(N-terminal)/b6/petB
PF07504 (1/1) Fungalysin/Thermolysin Propeptide Motif
PF05630 (1/1) Necrosis inducing protein (NPP1)
PF02868 (1/1) Thermolysin metallopeptidase, alpha-helical domain
PF01447 (1/1) Thermolysin metallopeptidase, catalytic domain

GCF_000739105.1

184.29 +- 0.00

0.06 +- 0.03

GCF_002300485.1

191.46 +- 93.23

0.06 +- 0.12

TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13460 (1/2) NAD(P)H-binding
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (1/2) Major Facilitator Superfamily
PF03067 (1/2) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF02127 (1/2) Aminopeptidase I zinc metalloprotease (M18)
PF00975 (1/2) Thioesterase domain
PF00877 (1/2) NlpC/P60 family
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/2) short chain dehydrogenase

GCF_002920635.1

320.42 +- 0.00

0.03 +- 0.03

PF16925 (1/1) Tetracyclin repressor-like, C-terminal domain
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF06779 (1/1) Uncharacterised MFS-type transporter YbfB
PF01965 (1/1) DJ-1/PfpI family
PF00440 (1/1) Bacterial regulatory proteins, tetR family

GCF_001445655.1

970.68 +- 552.63

0.01 +- 0.01

No common domains found

GCF_000365385.1

1526.50 +- 1483.50

0.03 +- 0.05

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/2) Helix-turn-helix domain
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF07690 (1/2) Major Facilitator Superfamily
PF04149 (1/2) Domain of unknown function (DUF397)
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00905 (1/2) Penicillin binding protein transpeptidase domain
PF00881 (1/2) Nitroreductase family
PF00266 (1/2) Aminotransferase class-V
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family

GCF_000718455.1

425.70 +- 0.00

0.02 +- 0.02

GCF_000715845.1

176.43 +- 46.43

0.02 +- 0.02

TIGR00229 (1/2) PAS domain S-box protein
PF13471 (1/2) Transglutaminase-like superfamily
PF08448 (1/2) PAS fold
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF01979 (1/2) Amidohydrolase family
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00733 (1/2) Asparagine synthase
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_900104815.1

177.93 +- 150.06

0.03 +- 0.04

No common domains found

GCF_003626535.1

677.93 +- 507.14

0.01 +- 0.02

No common domains found

GCF_003814875.1

312.81 +- 169.79

0.02 +- 0.06

No common domains found

GCF_003323715.1

128.40 +- 0.00

0.06 +- 0.05

PF13377 (1/1) Periplasmic binding protein-like domain
PF10022 (1/1) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (1/1) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF07045 (1/1) Domain of unknown function (DUF1330)
PF04030 (1/1) D-arabinono-1,4-lactone oxidase
PF02884 (1/1) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (1/1) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (1/1) Polysaccharide lyase family 8, super-sandwich domain
PF01565 (1/1) FAD binding domain
PF00722 (1/1) Glycosyl hydrolases family 16
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00067 (1/1) Cytochrome P450

GCF_000383595.1

3120.00 +- 0.00

0.01 +- 0.00

TIGR04245 (1/1) N-acyltransferase NodA
TIGR04243 (1/1) chitooligosaccharide deacetylase NodB
TIGR04242 (1/1) chitooligosaccharide synthase NodC
TIGR01188 (1/1) daunorubicin resistance ABC transporter, ATP-binding protein
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02474 (1/1) Nodulation protein A (NodA)
PF01522 (1/1) Polysaccharide deacetylase
PF01061 (1/1) ABC-2 type transporter
PF00535 (1/1) Glycosyl transferase family 2
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/1) ABC transporter

GCF_000722185.1

119.08 +- 41.08

0.07 +- 0.09

PF13581 (1/2) Histidine kinase-like ATPase domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13191 (1/2) AAA ATPase domain
PF12802 (1/2) MarR family
PF09346 (1/2) SMI1 / KNR4 family (SUKH-1)
PF09339 (1/2) IclR helix-turn-helix domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04978 (1/2) Protein of unknown function (DUF664)
PF04909 (1/2) Amidohydrolase
PF04199 (1/2) Putative cyclase
PF01614 (1/2) Bacterial transcriptional regulator
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/2) FAD binding domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00561 (1/2) alpha/beta hydrolase fold
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter

GCF_000719435.1

258.00 +- 0.00

0.01 +- 0.00

PF01757 (1/1) Acyltransferase family
PF00248 (1/1) Aldo/keto reductase family

GCF_001484625.1

618.38 +- 0.00

0.03 +- 0.03

TIGR04469 (1/1) CGA synthase-related protein
TIGR04468 (1/1) arginine 2,3-aminomutase
TIGR04467 (1/1) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (1/1) cytosylglucuronate decarboxylase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF08241 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF05014 (1/1) Nucleoside 2-deoxyribosyltransferase
PF04055 (1/1) Radical SAM superfamily
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00296 (1/1) Luciferase-like monooxygenase

GCF_001553455.1

263.15 +- 138.65

0.03 +- 0.05

No common domains found

GCF_002188345.1

304.39 +- 0.00

0.04 +- 0.04

TIGR03892 (1/1) thiazolylpeptide-type bacteriocin precursor
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF01959 (1/1) 3-dehydroquinate synthase II
PF01791 (1/1) DeoC/LacD family aldolase
PF01494 (1/1) FAD binding domain
PF00501 (1/1) AMP-binding enzyme

GCF_002154415.1

1231.32 +- 1108.68

0.03 +- 0.05

TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR00745 (1/2) 2-dehydropantoate 2-reductase
PF09084 (1/2) NMT1/THI5 like
PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF04055 (1/2) Radical SAM superfamily
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02597 (1/2) ThiS family
PF02558 (1/2) Ketopantoate reductase PanE/ApbA
PF02310 (1/2) B12 binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00155 (1/2) Aminotransferase class I and II
PF00106 (1/2) short chain dehydrogenase
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter

GCF_000424825.1

1161.00 +- 0.00

0.01 +- 0.00

PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF03704 (1/1) Bacterial transcriptional activator domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_003949695.1

51.60 +- 0.00

0.04 +- 0.03

PF01048 (1/1) Phosphorylase superfamily
PF00293 (1/1) NUDIX domain

GCF_002551055.1

22.61 +- 0.00

0.09 +- 0.08

PF13673 (1/1) Acetyltransferase (GNAT) domain
PF01872 (1/1) RibD C-terminal domain

GCF_001294335.1

242.77 +- 136.40

0.03 +- 0.02

PF00005 (2/2) ABC transporter
TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03731 (1/2) lantibiotic, gallidermin/nisin family
TIGR02276 (1/2) 40-residue YVTN family beta-propeller repeat
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF10282 (1/2) Lactonase, 7-bladed beta-propeller
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04072 (1/2) Leucine carboxyl methyltransferase
PF02052 (1/2) Gallidermin
PF01061 (1/2) ABC-2 type transporter
PF00664 (1/2) ABC transporter transmembrane region
PF00069 (1/2) Protein kinase domain

GCF_003268965.1

188.43 +- 122.64

0.04 +- 0.08

PF00440 (2/3) Bacterial regulatory proteins, tetR family

GCF_003665435.1

390.00 +- 0.00

0.01 +- 0.00

GCF_003698085.1

516.00 +- 0.00

0.01 +- 0.00

GCF_002910875.1

448.42 +- 177.41

0.06 +- 0.07

PF00005 (3/3) ABC transporter
PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region

GCF_002188365.1

660.18 +- 629.82

0.02 +- 0.02

TIGR02227 (1/2) signal peptidase I
PF17874 (1/2) MalT-like TPR region
PF10502 (1/2) Signal peptidase, peptidase S26
PF07291 (1/2) Methylamine utilisation protein MauE
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF03704 (1/2) Bacterial transcriptional activator domain
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00931 (1/2) NB-ARC domain
PF00899 (1/2) ThiF family
PF00717 (1/2) Peptidase S24-like
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00005 (1/2) ABC transporter

GCF_003634225.1

794.07 +- 758.65

0.04 +- 0.10

PF00005 (3/5) ABC transporter

GCF_003725745.1

119.08 +- 0.00

0.03 +- 0.04

PF13411 (1/1) MerR HTH family regulatory protein
PF07690 (1/1) Major Facilitator Superfamily
PF04909 (1/1) Amidohydrolase
PF02945 (1/1) Recombination endonuclease VII
PF01794 (1/1) Ferric reductase like transmembrane component
PF00175 (1/1) Oxidoreductase NAD-binding domain

GCF_002119195.1

258.03 +- 169.34

0.04 +- 0.10

PF01494 (2/4) FAD binding domain

GCF_002300355.1

541.67 +- 542.10

0.02 +- 0.02

No common domains found

GCF_001418575.1

270.45 +- 55.45

0.04 +- 0.04

TIGR03086 (1/2) TIGR03086 family protein
TIGR01891 (1/2) amidohydrolase
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF09084 (1/2) NMT1/THI5 like
PF07920 (1/2) Protein of unknown function (DUF1684)
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01546 (1/2) Peptidase family M20/M25/M40
PF00581 (1/2) Rhodanese-like domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00376 (1/2) MerR family regulatory protein
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_002551295.1

294.86 +- 0.00

0.01 +- 0.01

TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/1) SseB protein N-terminal domain
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/1) Glycosyltransferase sugar-binding region containing DXD motif
PF02575 (1/1) YbaB/EbfC DNA-binding family

GCF_001865255.1

1040.00 +- 0.00

0.01 +- 0.00

TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
PF13489 (1/1) Methyltransferase domain
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13394 (1/1) 4Fe-4S single cluster domain
PF04055 (1/1) Radical SAM superfamily
PF02223 (1/1) Thymidylate kinase
PF01259 (1/1) SAICAR synthetase
PF01242 (1/1) 6-pyruvoyl tetrahydropterin synthase
PF01227 (1/1) GTP cyclohydrolase I
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00929 (1/1) Exonuclease
PF00156 (1/1) Phosphoribosyl transferase domain

GCF_002551065.1

164.18 +- 0.00

0.04 +- 0.02

GCF_000719425.1

195.00 +- 65.00

0.01 +- 0.01

PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03130 (1/2) PBS lyase HEAT-like repeat
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase

GCF_001279105.1

57.78 +- 0.00

0.05 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_002727115.1

516.00 +- 0.00

0.01 +- 0.00

GCF_003550115.1

704.49 +- 736.25

0.03 +- 0.06

PF00005 (2/3) ABC transporter

GCF_002188355.1

194.62 +- 33.37

0.07 +- 0.07

TIGR00745 (1/2) 2-dehydropantoate 2-reductase
TIGR00055 (1/2) di-trans,poly-cis-decaprenylcistransferase
PF14310 (1/2) Fibronectin type III-like domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13529 (1/2) Peptidase_C39 like family
PF13515 (1/2) Fusaric acid resistance protein-like
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13202 (1/2) EF hand
PF12833 (1/2) Helix-turn-helix domain
PF09995 (1/2) Uncharacterized protein conserved in bacteria (DUF2236)
PF08546 (1/2) Ketopantoate reductase PanE/ApbA C terminal
PF08386 (1/2) TAP-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02558 (1/2) Ketopantoate reductase PanE/ApbA
PF01965 (1/2) DJ-1/PfpI family
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01546 (1/2) Peptidase family M20/M25/M40
PF01522 (1/2) Polysaccharide deacetylase
PF01471 (1/2) Putative peptidoglycan binding domain
PF01255 (1/2) Putative undecaprenyl diphosphate synthase
PF01037 (1/2) Lrp/AsnC ligand binding domain
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)
PF00083 (1/2) Sugar (and other) transporter

GCF_001553435.1

268.35 +- 119.41

0.02 +- 0.01

PF07690 (3/4) Major Facilitator Superfamily

GCF_001279495.1

618.44 +- 542.56

0.03 +- 0.05

GCF_004212445.1

246.07 +- 192.36

0.04 +- 0.13

PF07690 (3/5) Major Facilitator Superfamily
PF04055 (3/5) Radical SAM superfamily

GCF_000719355.1

1043.58 +- 742.58

0.02 +- 0.02

TIGR03898 (1/2) type 2 lantibiotic, mersacidin/lichenicidin family
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12679 (1/2) ABC-2 family transporter protein
PF05193 (1/2) Peptidase M16 inactive domain
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04978 (1/2) Protein of unknown function (DUF664)
PF03412 (1/2) Peptidase C39 family
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00005 (1/2) ABC transporter

GCF_002754515.1

661.82 +- 378.18

0.06 +- 0.08

TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01234 (1/2) ribulokinase
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF14016 (1/2) Protein of unknown function (DUF4232)
PF11762 (1/2) L-arabinose isomerase C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF05193 (1/2) Peptidase M16 inactive domain
PF03358 (1/2) NADPH-dependent FMN reductase
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02610 (1/2) L-arabinose isomerase
PF02517 (1/2) CPBP intramembrane metalloprotease
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain

GCF_001419765.1

244.42 +- 0.00

0.02 +- 0.01

TIGR01296 (1/1) aspartate-semialdehyde dehydrogenase
PF12833 (1/1) Helix-turn-helix domain
PF02774 (1/1) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (1/1) DJ-1/PfpI family
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (1/1) Amino acid kinase family
PF00465 (1/1) Iron-containing alcohol dehydrogenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00171 (1/1) Aldehyde dehydrogenase family

GCF_001279935.1

856.51 +- 814.91

0.02 +- 0.03

TIGR01426 (1/2) glycosyltransferase, MGT family
PF18616 (1/2) CDI immunity proteins
PF18029 (1/2) Glyoxalase-like domain
PF17914 (1/2) HopA1 effector protein family
PF13692 (1/2) Glycosyl transferases group 1
PF13649 (1/2) Methyltransferase domain
PF13601 (1/2) Winged helix DNA-binding domain
PF12698 (1/2) ABC-2 family transporter protein
PF06276 (1/2) Ferric iron reductase FhuF-like transporter
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF04183 (1/2) IucA / IucC family
PF02441 (1/2) Flavoprotein
PF01636 (1/2) Phosphotransferase enzyme family
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00664 (1/2) ABC transporter transmembrane region
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase
PF00005 (1/2) ABC transporter

GCF_002289305.1

690.33 +- 625.33

0.04 +- 0.06

TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13340 (1/2) Putative transposase of IS4/5 family (DUF4096)
PF13338 (1/2) Transcriptional regulator, AbiEi antitoxin
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12770 (1/2) CHAT domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/2) Sigma-70, region 4
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF07510 (1/2) Protein of unknown function (DUF1524)
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF03929 (1/2) PepSY-associated TM region
PF03235 (1/2) Protein of unknown function DUF262
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01794 (1/2) Ferric reductase like transmembrane component
PF01636 (1/2) Phosphotransferase enzyme family
PF01609 (1/2) Transposase DDE domain
PF01497 (1/2) Periplasmic binding protein
PF01035 (1/2) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF01032 (1/2) FecCD transport family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter

GCF_900105275.1

338.45 +- 181.55

0.03 +- 0.04

TIGR04267 (1/2) HEXXH motif domain
TIGR01187 (1/2) polyamine ABC transporter, ATP-binding protein
TIGR00702 (1/2) YcaO-type kinase domain
PF18029 (1/2) Glyoxalase-like domain
PF13489 (1/2) Methyltransferase domain
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF08402 (1/2) TOBE domain
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01593 (1/2) Flavin containing amine oxidoreductase
PF00848 (1/2) Ring hydroxylating alpha subunit (catalytic domain)
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter

GCF_003947575.1

227.50 +- 315.57

0.03 +- 0.03

PF00733 (2/4) Asparagine synthase

GCF_003259355.1

190.87 +- 90.07

0.06 +- 0.14

PF07729 (2/3) FCD domain
PF00392 (2/3) Bacterial regulatory proteins, gntR family

GCF_000720605.1

131.15 +- 44.17

0.03 +- 0.04

No common domains found

GCF_004125315.1

230.24 +- 94.74

0.05 +- 0.10

PF07690 (2/4) Major Facilitator Superfamily

GCF_001270495.1

500.90 +- 402.10

0.04 +- 0.06

GCF_002910825.1

331.96 +- 0.00

0.04 +- 0.01

TIGR03561 (1/1) peroxiredoxin, Ohr subfamily
PF13649 (1/1) Methyltransferase domain
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/1) IclR helix-turn-helix domain
PF09084 (1/1) NMT1/THI5 like
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF02566 (1/1) OsmC-like protein
PF01614 (1/1) Bacterial transcriptional regulator
PF01546 (1/1) Peptidase family M20/M25/M40
PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family
PF00561 (1/1) alpha/beta hydrolase fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter

GCF_000716445.1

752.38 +- 183.71

0.02 +- 0.01

PF13378 (2/4) Enolase C-terminal domain-like
PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00005 (2/4) ABC transporter

GCF_000367365.1

188.34 +- 118.24

0.04 +- 0.10

No common domains found

GCF_001184025.1

120.12 +- 80.47

0.06 +- 0.16

No common domains found

GCF_004122735.1

646.47 +- 30.78

0.01 +- 0.01

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
TIGR01392 (1/2) homoserine O-acetyltransferase
TIGR01326 (1/2) O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13191 (1/2) AAA ATPase domain
PF12710 (1/2) haloacid dehalogenase-like hydrolase
PF07722 (1/2) Peptidase C26
PF07690 (1/2) Major Facilitator Superfamily
PF04321 (1/2) RmlD substrate binding domain
PF04185 (1/2) Phosphoesterase family
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF01979 (1/2) Amidohydrolase family
PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme
PF00892 (1/2) EamA-like transporter family
PF00561 (1/2) alpha/beta hydrolase fold
PF00535 (1/2) Glycosyl transferase family 2
PF00487 (1/2) Fatty acid desaturase
PF00480 (1/2) ROK family
PF00459 (1/2) Inositol monophosphatase family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_001514305.1

258.00 +- 0.00

0.02 +- 0.02

PF13523 (1/1) Acetyltransferase (GNAT) domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00501 (1/1) AMP-binding enzyme
PF00106 (1/1) short chain dehydrogenase

GCF_000302615.1

761.41 +- 591.24

0.02 +- 0.01

No common domains found

GCF_003671715.1

520.00 +- 0.00

0.02 +- 0.01

PF13649 (1/1) Methyltransferase domain
PF12698 (1/1) ABC-2 family transporter protein
PF02441 (1/1) Flavoprotein
PF00005 (1/1) ABC transporter

GCF_000514995.1

577.33 +- 196.67

0.03 +- 0.02

TIGR01733 (1/2) amino acid adenylation domain
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF17645 (1/2) Arylmalonate decarboxylase
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF09339 (1/2) IclR helix-turn-helix domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05685 (1/2) Putative restriction endonuclease
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02426 (1/2) Muconolactone delta-isomerase
PF01636 (1/2) Phosphotransferase enzyme family
PF01614 (1/2) Bacterial transcriptional regulator
PF01593 (1/2) Flavin containing amine oxidoreductase
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00326 (1/2) Prolyl oligopeptidase family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter

GCF_001905345.1

497.47 +- 317.11

0.02 +- 0.03

No common domains found

GCF_002803175.1

2064.71 +- 0.00

0.01 +- 0.01

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13575 (1/1) Domain of unknown function (DUF4135)
PF12730 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03703 (1/1) Bacterial PH domain
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00005 (1/1) ABC transporter

GCF_001190165.1

96.18 +- 0.00

0.08 +- 0.19

TIGR01762 (1/1) chlorinating enzyme
TIGR01733 (1/1) amino acid adenylation domain
TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
TIGR01444 (1/1) methyltransferase, FkbM family
TIGR00843 (1/1) benzoate transporter
PF16990 (1/1) Carbohydrate binding module (family 35)
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF13454 (1/1) FAD-NAD(P)-binding
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07691 (1/1) PA14 domain
PF06439 (1/1) Domain of Unknown Function (DUF1080)
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF05050 (1/1) Methyltransferase FkbM domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF03594 (1/1) Benzoate membrane transport protein
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01116 (1/1) Fructose-bisphosphate aldolase class-II
PF00975 (1/1) Thioesterase domain
PF00892 (1/1) EamA-like transporter family
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain

GCF_001885705.1

162.58 +- 127.13

0.06 +- 0.10

PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13671 (1/2) AAA domain
PF13535 (1/2) ATP-grasp domain
PF12911 (1/2) N-terminal TM domain of oligopeptide transport permease C
PF12833 (1/2) Helix-turn-helix domain
PF11706 (1/2) CGNR zinc finger
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF07336 (1/2) Putative stress-induced transcription regulator
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01965 (1/2) DJ-1/PfpI family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF00696 (1/2) Amino acid kinase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00107 (1/2) Zinc-binding dehydrogenase

GCF_003977875.1

354.75 +- 161.25

0.01 +- 0.01

TIGR01840 (1/2) esterase, PHB depolymerase family
TIGR00702 (1/2) YcaO-type kinase domain
TIGR00666 (1/2) D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase
PF18029 (1/2) Glyoxalase-like domain
PF14016 (1/2) Protein of unknown function (DUF4232)
PF13489 (1/2) Methyltransferase domain
PF13231 (1/2) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF10503 (1/2) Esterase PHB depolymerase
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02113 (1/2) D-Ala-D-Ala carboxypeptidase 3 (S13) family
PF00067 (1/2) Cytochrome P450

GCF_002846355.1

47.12 +- 16.48

0.06 +- 0.04

No common domains found

GCF_003977855.1

150.94 +- 0.00

0.01 +- 0.00

TIGR00398 (1/1) methionine--tRNA ligase
TIGR00010 (1/1) hydrolase, TatD family
PF09334 (1/1) tRNA synthetases class I (M)
PF07501 (1/1) G5 domain
PF06737 (1/1) Transglycosylase-like domain
PF03990 (1/1) G5-linked-Ubiquitin-like domain
PF01026 (1/1) TatD related DNase

GCF_001753425.1

196.30 +- 0.00

0.07 +- 0.09

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00931 (1/1) NB-ARC domain
PF00881 (1/1) Nitroreductase family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter

GCF_001905485.1

478.70 +- 415.73

0.04 +- 0.04

No common domains found

GCF_001013905.1

1677.00 +- 0.00

0.01 +- 0.00

PF17914 (1/1) HopA1 effector protein family
PF02441 (1/1) Flavoprotein
PF01061 (1/1) ABC-2 type transporter
PF00891 (1/1) O-methyltransferase domain
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_004124325.1

1418.18 +- 0.00

0.01 +- 0.00

PF13738 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07722 (1/1) Peptidase C26
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF00202 (1/1) Aminotransferase class-III
PF00171 (1/1) Aldehyde dehydrogenase family
PF00120 (1/1) Glutamine synthetase, catalytic domain
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_003386245.1

1182.19 +- 402.19

0.04 +- 0.15

TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03856 (1/2) probable F420-dependent oxidoreductase, MSMEG_2906 family
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01686 (1/2) FkbH domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF18563 (1/2) TubC N-terminal docking domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF16058 (1/2) Mucin-like
PF14765 (1/2) Polyketide synthase dehydratase
PF13602 (1/2) Zinc-binding dehydrogenase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF03972 (1/2) MmgE/PrpD family
PF03621 (1/2) MbtH-like protein
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02195 (1/2) ParB-like nuclease domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01266 (1/2) FAD dependent oxidoreductase
PF00975 (1/2) Thioesterase domain
PF00881 (1/2) Nitroreductase family
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00698 (1/2) Acyl transferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00005 (1/2) ABC transporter

GCF_900103455.1

394.48 +- 0.00

0.03 +- 0.03

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF13377 (1/1) Periplasmic binding protein-like domain
PF11941 (1/1) Domain of unknown function (DUF3459)
PF03777 (1/1) ChpA-C
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00293 (1/1) NUDIX domain
PF00128 (1/1) Alpha amylase, catalytic domain

GCF_001953885.1

397.17 +- 301.03

0.04 +- 0.14

No common domains found

GCF_900207595.1

79.68 +- 49.32

0.09 +- 0.12

PF00440 (2/2) Bacterial regulatory proteins, tetR family
TIGR00229 (1/2) PAS domain S-box protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF12680 (1/2) SnoaL-like domain
PF08448 (1/2) PAS fold
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF07045 (1/2) Domain of unknown function (DUF1330)
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF01738 (1/2) Dienelactone hydrolase family
PF01590 (1/2) GAF domain
PF00664 (1/2) ABC transporter transmembrane region
PF00455 (1/2) DeoR C terminal sensor domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_001729485.1

651.76 +- 359.14

0.02 +- 0.03

PF00005 (2/3) ABC transporter

GCF_900091895.1

241.43 +- 0.00

0.05 +- 0.10

GCF_003344905.1

1765.69 +- 1717.31

0.01 +- 0.02

TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF12680 (1/2) SnoaL-like domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF05199 (1/2) GMC oxidoreductase
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02571 (1/2) Precorrin-6x reductase CbiJ/CobK
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase
PF00930 (1/2) Dipeptidyl peptidase IV (DPP IV) N-terminal region
PF00732 (1/2) GMC oxidoreductase
PF00561 (1/2) alpha/beta hydrolase fold
PF00544 (1/2) Pectate lyase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00450 (1/2) Serine carboxypeptidase
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00326 (1/2) Prolyl oligopeptidase family
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter

GCF_000721605.1

681.06 +- 0.00

0.05 +- 0.03

TIGR04364 (1/1) methyltransferase, FxLD system
TIGR04363 (1/1) FxLD family lantipeptide
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13649 (1/1) Methyltransferase domain
PF05331 (1/1) Protein of unknown function (DUF742)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03259 (1/1) Roadblock/LC7 domain
PF03029 (1/1) Conserved hypothetical ATP binding protein
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01590 (1/1) GAF domain
PF01427 (1/1) D-ala-D-ala dipeptidase
PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00723 (1/1) Glycosyl hydrolases family 15
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00293 (1/1) NUDIX domain
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter

GCF_000718015.1

436.62 +- 0.00

0.01 +- 0.00

TIGR03930 (1/1) WXG100 family type VII secretion target
TIGR03920 (1/1) type VII secretion integral membrane protein EccD
TIGR03919 (1/1) type VII secretion protein EccB
PF17866 (1/1) AAA lid domain
PF13229 (1/1) Right handed beta helix region
PF08817 (1/1) WXG100 protein secretion system (Wss), protein YukD
PF06013 (1/1) Proteins of 100 residues with WXG
PF05108 (1/1) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/1) YbaB/EbfC DNA-binding family
PF00004 (1/1) ATPase family associated with various cellular activities (AAA)

GCF_000647875.1

663.56 +- 614.03

0.03 +- 0.03

TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (1/2) ATP-grasp domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13115 (1/2) YtkA-like
PF04389 (1/2) Peptidase family M28
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF01676 (1/2) Metalloenzyme superfamily
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00664 (1/2) ABC transporter transmembrane region
PF00403 (1/2) Heavy-metal-associated domain
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/2) Aminotransferase class I and II
PF00122 (1/2) E1-E2 ATPase
PF00117 (1/2) Glutamine amidotransferase class-I
PF00005 (1/2) ABC transporter

GCF_000816465.3

975.00 +- 325.00

0.01 +- 0.00

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
PF17933 (1/2) Tetracyclin repressor-like, C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF06100 (1/2) MCRA family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/2) CPBP intramembrane metalloprotease
PF01553 (1/2) Acyltransferase
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_001443625.1

2604.19 +- 3271.71

0.02 +- 0.04

No common domains found

GCF_001941275.1

346.67 +- 0.00

0.09 +- 0.23

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF10901 (1/1) Protein of unknown function (DUF2690)
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01471 (1/1) Putative peptidoglycan binding domain
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00664 (1/1) ABC transporter transmembrane region
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
PF00005 (1/1) ABC transporter

GCF_001280015.1

250.83 +- 7.17

0.09 +- 0.22

TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01733 (1/2) amino acid adenylation domain
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF14765 (1/2) Polyketide synthase dehydratase
PF13602 (1/2) Zinc-binding dehydrogenase
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08990 (1/2) Erythronolide synthase docking
PF08659 (1/2) KR domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00696 (1/2) Amino acid kinase family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00067 (1/2) Cytochrome P450

GCF_003846285.1

41.61 +- 0.00

0.10 +- 0.09

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (1/1) Major Facilitator Superfamily
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00067 (1/1) Cytochrome P450

GCF_004196115.1

440.26 +- 0.00

0.09 +- 0.09

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF03929 (1/1) PepSY-associated TM region
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01794 (1/1) Ferric reductase like transmembrane component
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter

GCF_002803155.1

60.00 +- 0.00

0.05 +- 0.07

PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13333 (1/1) Integrase core domain
PF13276 (1/1) HTH-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF04309 (1/1) Glycerol-3-phosphate responsive antiterminator
PF02913 (1/1) FAD linked oxidases, C-terminal domain
PF02782 (1/1) FGGY family of carbohydrate kinases, C-terminal domain
PF01565 (1/1) FAD binding domain
PF01527 (1/1) Transposase
PF00665 (1/1) Integrase core domain
PF00370 (1/1) FGGY family of carbohydrate kinases, N-terminal domain

GCF_003367645.1

209.79 +- 255.39

0.05 +- 0.06

No common domains found

GCF_000716935.1

386.46 +- 260.58

0.04 +- 0.11

No common domains found

GCF_001294345.1

347.31 +- 0.00

0.01 +- 0.01

PF12802 (1/1) MarR family
PF09339 (1/1) IclR helix-turn-helix domain
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF01614 (1/1) Bacterial transcriptional regulator
PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family
PF01494 (1/1) FAD binding domain

GCF_001905735.1

383.20 +- 125.61

0.02 +- 0.02

PF07690 (2/3) Major Facilitator Superfamily

GCF_004196225.1

200.42 +- 27.08

0.02 +- 0.01

GCF_003933485.1

103.06 +- 92.72

0.05 +- 0.08

No common domains found

GCF_001611795.1

723.30 +- 733.73

0.02 +- 0.03

No common domains found

GCF_900090095.1

165.86 +- 0.00

0.02 +- 0.01

PF07883 (1/1) Cupin domain
PF01872 (1/1) RibD C-terminal domain
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (1/1) Acetyltransferase (GNAT) family

GCF_000720135.1

82.10 +- 32.52

0.05 +- 0.07

No common domains found

GCF_002761895.1

520.00 +- 0.00

0.03 +- 0.01

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain

GCF_002633395.1

381.00 +- 247.21

0.06 +- 0.16

PF00005 (2/3) ABC transporter

GCF_000719135.1

313.18 +- 206.82

0.05 +- 0.07

PF00005 (2/2) ABC transporter
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00546 (1/2) apolipoprotein N-acyltransferase
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07291 (1/2) Methylamine utilisation protein MauE
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00717 (1/2) Peptidase S24-like
PF00664 (1/2) ABC transporter transmembrane region

GCF_900199205.1

881.25 +- 400.12

0.02 +- 0.05

No common domains found

GCF_002317025.1

540.57 +- 0.00

0.07 +- 0.06

GCF_000220705.2

650.00 +- 0.00

0.01 +- 0.00

GCF_002754535.1

728.90 +- 670.15

0.01 +- 0.02

TIGR01733 (2/4) amino acid adenylation domain
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme

GCF_003949875.1

910.59 +- 0.00

0.01 +- 0.01

TIGR00414 (1/1) serine--tRNA ligase
PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF13546 (1/1) DDE superfamily endonuclease
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF02403 (1/1) Seryl-tRNA synthetase N-terminal domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00587 (1/1) tRNA synthetase class II core domain (G, H, P, S and T)
PF00005 (1/1) ABC transporter

GCF_001905385.1

187.82 +- 0.00

0.07 +- 0.22

PF17914 (1/1) HopA1 effector protein family
PF13649 (1/1) Methyltransferase domain
PF13280 (1/1) WYL domain
PF08279 (1/1) HTH domain
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter

GCF_001484565.1

394.49 +- 270.04

0.05 +- 0.16

No common domains found

GCF_003671735.1

187.53 +- 156.47

0.07 +- 0.06

TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF18130 (1/2) ATP-grasp N-terminal domain
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13471 (1/2) Transglutaminase-like superfamily
PF13462 (1/2) Thioredoxin
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF12730 (1/2) ABC-2 family transporter protein
PF09587 (1/2) Bacterial capsule synthesis protein PGA_cap
PF08239 (1/2) Bacterial SH3 domain
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF07681 (1/2) DoxX
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF03771 (1/2) Domain of unknown function (DUF317)
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01638 (1/2) HxlR-like helix-turn-helix
PF01061 (1/2) ABC-2 type transporter
PF00733 (1/2) Asparagine synthase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_000375625.1

262.50 +- 0.00

0.05 +- 0.07

TIGR03975 (1/1) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
PF10025 (1/1) Uncharacterized conserved protein (DUF2267)
PF08281 (1/1) Sigma-70, region 4
PF07690 (1/1) Major Facilitator Superfamily
PF04542 (1/1) Sigma-70 region 2
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain
PF01833 (1/1) IPT/TIG domain
PF00355 (1/1) Rieske [2Fe-2S] domain
PF00326 (1/1) Prolyl oligopeptidase family
PF00067 (1/1) Cytochrome P450

GCF_004196125.1

427.23 +- 0.00

0.07 +- 0.08

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13191 (1/1) AAA ATPase domain
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter

GCF_001270575.1

241.43 +- 18.57

0.01 +- 0.01

PF12833 (1/2) Helix-turn-helix domain
PF09848 (1/2) Uncharacterized conserved protein (DUF2075)
PF07733 (1/2) Bacterial DNA polymerase III alpha NTPase domain
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF07045 (1/2) Domain of unknown function (DUF1330)
PF02311 (1/2) AraC-like ligand binding domain
PF00931 (1/2) NB-ARC domain

GCF_000504065.1

636.93 +- 709.20

0.02 +- 0.06

No common domains found

GCF_001941285.1

185.15 +- 130.00

0.09 +- 0.21

PF07690 (2/2) Major Facilitator Superfamily
TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14542 (1/2) GCN5-related N-acetyl-transferase
PF13560 (1/2) Helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF12802 (1/2) MarR family
PF10901 (1/2) Protein of unknown function (DUF2690)
PF08443 (1/2) RimK-like ATP-grasp domain
PF05726 (1/2) Pirin C-terminal cupin domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02678 (1/2) Pirin
PF01546 (1/2) Peptidase family M20/M25/M40
PF01471 (1/2) Putative peptidoglycan binding domain
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00664 (1/2) ABC transporter transmembrane region
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00089 (1/2) Trypsin
PF00005 (1/2) ABC transporter

GCF_002812405.1

840.29 +- 1266.40

0.05 +- 0.16

No common domains found

GCF_003323735.1

336.18 +- 217.79

0.05 +- 0.19

No common domains found

GCF_001941845.1

90.43 +- 0.00

0.04 +- 0.05

PF14903 (1/1) WG containing repeat
PF10042 (1/1) Uncharacterized conserved protein (DUF2278)
PF06983 (1/1) 3-demethylubiquinone-9 3-methyltransferase
PF00950 (1/1) ABC 3 transport family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00005 (1/1) ABC transporter

GCF_004125275.1

224.68 +- 111.74

0.03 +- 0.05

PF00067 (3/5) Cytochrome P450

GCF_003344965.1

406.87 +- 254.42

0.04 +- 0.14

PF00733 (3/6) Asparagine synthase

GCF_000424945.1

337.93 +- 326.96

0.04 +- 0.13

No common domains found

GCF_000262345.1

179.31 +- 0.00

0.04 +- 0.04

PF07702 (1/1) UTRA domain
PF04672 (1/1) S-adenosyl methyltransferase
PF03747 (1/1) ADP-ribosylglycohydrolase
PF02133 (1/1) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase

GCF_002891295.1

607.20 +- 324.93

0.04 +- 0.09

PF00005 (2/2) ABC transporter
TIGR03892 (1/2) thiazolylpeptide-type bacteriocin precursor
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/2) amidohydrolase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13622 (1/2) Thioesterase-like superfamily
PF12679 (1/2) ABC-2 family transporter protein
PF12146 (1/2) Serine aminopeptidase, S33
PF07690 (1/2) Major Facilitator Superfamily
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01546 (1/2) Peptidase family M20/M25/M40
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00487 (1/2) Fatty acid desaturase
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00301 (1/2) Rubredoxin
PF00296 (1/2) Luciferase-like monooxygenase
PF00067 (1/2) Cytochrome P450

GCF_003814765.1

163.38 +- 131.83

0.06 +- 0.08

No common domains found

GCF_000721035.1

108.33 +- 0.00

0.09 +- 0.14

PF13796 (1/1) Putative sensor
PF07730 (1/1) Histidine kinase
PF03551 (1/1) Transcriptional regulator PadR-like family
PF03372 (1/1) Endonuclease/Exonuclease/phosphatase family
PF02518 (1/1) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00768 (1/1) D-alanyl-D-alanine carboxypeptidase
PF00672 (1/1) HAMP domain
PF00512 (1/1) His Kinase A (phospho-acceptor) domain
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain

GCF_003865155.1

62.81 +- 29.94

0.06 +- 0.09

No common domains found

GCF_000297635.1

260.00 +- 0.00

0.01 +- 0.00

TIGR04085 (1/1) radical SAM additional 4Fe4S-binding SPASM domain
PF16861 (1/1) Carbamoyltransferase C-terminus
PF04055 (1/1) Radical SAM superfamily
PF02543 (1/1) Carbamoyltransferase N-terminus

GCF_002910895.1

106.48 +- 51.19

0.06 +- 0.01

TIGR00126 (1/2) deoxyribose-phosphate aldolase
PF13649 (1/2) Methyltransferase domain
PF13407 (1/2) Periplasmic binding protein domain
PF07702 (1/2) UTRA domain
PF07690 (1/2) Major Facilitator Superfamily
PF05025 (1/2) RbsD / FucU transport protein family
PF04055 (1/2) Radical SAM superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00005 (1/2) ABC transporter

GCF_001865795.1

737.28 +- 453.48

0.06 +- 0.06

PF00005 (2/2) ABC transporter
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF13191 (1/2) AAA ATPase domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/2) Sigma-70, region 4
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF03929 (1/2) PepSY-associated TM region
PF03704 (1/2) Bacterial transcriptional activator domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01965 (1/2) DJ-1/PfpI family
PF01794 (1/2) Ferric reductase like transmembrane component
PF01497 (1/2) Periplasmic binding protein
PF01061 (1/2) ABC-2 type transporter
PF01032 (1/2) FecCD transport family
PF00881 (1/2) Nitroreductase family
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase

GCF_001507435.1

240.80 +- 0.00

0.02 +- 0.02

PF13365 (1/1) Trypsin-like peptidase domain
PF07721 (1/1) Tetratricopeptide repeat
PF00400 (1/1) WD domain, G-beta repeat
PF00248 (1/1) Aldo/keto reductase family

GCF_001418565.1

48.38 +- 0.00

0.06 +- 0.08

TIGR04187 (1/1) ATP-grasp ribosomal peptide maturase, SAV_5884 family
TIGR04186 (1/1) putative ATP-grasp target RiPP
PF14404 (1/1) Ribosomally synthesized peptide in Streptomyces species
PF04672 (1/1) S-adenosyl methyltransferase
PF00583 (1/1) Acetyltransferase (GNAT) family

GCF_001975025.1

357.43 +- 192.34

0.03 +- 0.11

PF07690 (3/4) Major Facilitator Superfamily
PF04055 (2/4) Radical SAM superfamily
PF02310 (2/4) B12 binding domain
PF00326 (2/4) Prolyl oligopeptidase family

GCF_000717845.1

308.48 +- 0.00

0.04 +- 0.04

GCF_002846625.1

86.67 +- 0.00

0.09 +- 0.11

TIGR01413 (1/1) Dyp-type peroxidase family
TIGR00711 (1/1) drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
PF16859 (1/1) Tetracyclin repressor-like, C-terminal domain
PF14559 (1/1) Tetratricopeptide repeat
PF14224 (1/1) Domain of unknown function (DUF4331)
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF00925 (1/1) GTP cyclohydrolase II
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_000716805.1

210.54 +- 112.09

0.06 +- 0.10

PF02826 (2/4) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF00005 (2/4) ABC transporter

GCF_000721595.1

461.67 +- 439.77

0.04 +- 0.05

PF04055 (2/4) Radical SAM superfamily

GCF_003263885.1

421.07 +- 325.46

0.02 +- 0.03

PF00005 (2/3) ABC transporter

GCF_002847285.1

189.18 +- 50.11

0.06 +- 0.09

PF01546 (2/3) Peptidase family M20/M25/M40

GCF_000717815.1

36.86 +- 0.00

0.05 +- 0.00

PF12833 (1/1) Helix-turn-helix domain
PF02311 (1/1) AraC-like ligand binding domain
PF00150 (1/1) Cellulase (glycosyl hydrolase family 5)

GCF_900105415.1

295.69 +- 224.31

0.03 +- 0.09

TIGR01549 (1/2) HAD hydrolase, family IA, variant 1
TIGR01249 (1/2) prolyl aminopeptidase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF07690 (1/2) Major Facilitator Superfamily
PF06821 (1/2) Serine hydrolase
PF06245 (1/2) Protein of unknown function (DUF1015)
PF04389 (1/2) Peptidase family M28
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02225 (1/2) PA domain
PF01557 (1/2) Fumarylacetoacetate (FAA) hydrolase family
PF00561 (1/2) alpha/beta hydrolase fold
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain

GCF_002090335.1

289.34 +- 148.57

0.04 +- 0.05

PF00005 (2/4) ABC transporter

GCF_000720325.1

237.81 +- 165.66

0.04 +- 0.07

No common domains found

GCF_000716335.1

671.67 +- 498.33

0.01 +- 0.00

TIGR01536 (1/2) asparagine synthase (glutamine-hydrolyzing)
PF14805 (1/2) Tetrahydrodipicolinate N-succinyltransferase N-terminal
PF14602 (1/2) Hexapeptide repeat of succinyl-transferase
PF14099 (1/2) Polysaccharide lyase
PF13537 (1/2) Glutamine amidotransferase domain
PF13535 (1/2) ATP-grasp domain
PF10935 (1/2) Protein of unknown function (DUF2637)
PF08241 (1/2) Methyltransferase domain
PF05199 (1/2) GMC oxidoreductase
PF02784 (1/2) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/2) Peptidase family M20/M25/M40
PF00892 (1/2) EamA-like transporter family
PF00754 (1/2) F5/8 type C domain
PF00733 (1/2) Asparagine synthase
PF00732 (1/2) GMC oxidoreductase
PF00278 (1/2) Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF00155 (1/2) Aminotransferase class I and II
PF00132 (1/2) Bacterial transferase hexapeptide (six repeats)
PF00082 (1/2) Subtilase family

GCF_001905005.1

355.34 +- 324.66

0.02 +- 0.04

PF07690 (2/3) Major Facilitator Superfamily

GCF_001592685.1

279.00 +- 280.87

0.04 +- 0.13

No common domains found

GCF_000718755.1

54.36 +- 10.14

0.05 +- 0.02

PF13471 (1/2) Transglutaminase-like superfamily
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00733 (1/2) Asparagine synthase
PF00067 (1/2) Cytochrome P450

GCF_900091795.1

1020.07 +- 621.75

0.04 +- 0.06

PF05147 (2/2) Lanthionine synthetase C-like protein
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12730 (1/2) ABC-2 family transporter protein
PF08877 (1/2) MepB protein
PF04672 (1/2) S-adenosyl methyltransferase
PF03412 (1/2) Peptidase C39 family
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain

GCF_004217285.1

222.66 +- 0.00

0.08 +- 0.06

TIGR01409 (1/1) Tat (twin-arginine translocation) pathway signal sequence
PF03814 (1/1) Potassium-transporting ATPase A subunit
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00331 (1/1) Glycosyl hydrolase family 10

GCF_001270515.1

1173.90 +- 495.52

0.01 +- 0.00

PF13378 (2/4) Enolase C-terminal domain-like
PF02746 (2/4) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF00005 (2/4) ABC transporter

GCF_001653115.1

567.27 +- 0.00

0.02 +- 0.02

GCF_003112555.1

436.50 +- 369.53

0.03 +- 0.04

PF07690 (3/4) Major Facilitator Superfamily
PF00682 (2/4) HMGL-like
PF00180 (2/4) Isocitrate/isopropylmalate dehydrogenase

GCF_003671755.1

44.57 +- 0.00

0.07 +- 0.03

PF07690 (1/1) Major Facilitator Superfamily
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain
PF00171 (1/1) Aldehyde dehydrogenase family

GCF_000718775.1

153.93 +- 34.10

0.04 +- 0.05

No common domains found

GCF_002017835.1

268.13 +- 175.76

0.04 +- 0.07

PF07690 (4/6) Major Facilitator Superfamily

GCF_000380165.1

23.45 +- 0.00

0.09 +- 0.07

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (1/1) Methyltransferase domain
PF00753 (1/1) Metallo-beta-lactamase superfamily

GCF_000980885.2

96.75 +- 0.00

0.02 +- 0.02

PF05544 (1/1) Proline racemase
PF05195 (1/1) Aminopeptidase P, N-terminal domain
PF00557 (1/1) Metallopeptidase family M24

GCF_000701325.1

234.00 +- 0.00

0.04 +- 0.05

PF13416 (1/1) Bacterial extracellular solute-binding protein
PF08533 (1/1) Beta-galactosidase C-terminal domain
PF01229 (1/1) Glycosyl hydrolases family 39
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component

GCF_000381025.1

201.72 +- 154.65

0.04 +- 0.09

No common domains found

GCF_000717805.1

57.78 +- 0.00

0.05 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_003610145.1

190.93 +- 110.16

0.04 +- 0.05

No common domains found

GCF_000377145.1

129.00 +- 0.00

0.09 +- 0.25

PF17914 (1/1) HopA1 effector protein family
PF05193 (1/1) Peptidase M16 inactive domain
PF02441 (1/1) Flavoprotein
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter

GCF_000158935.1

181.01 +- 0.00

0.06 +- 0.03

GCF_004217425.1

450.69 +- 541.09

0.05 +- 0.08

No common domains found

GCF_003112595.1

539.62 +- 0.00

0.04 +- 0.03

GCF_900100315.1

774.00 +- 0.00

0.01 +- 0.00

TIGR03696 (1/1) RHS repeat-associated core domain
TIGR01443 (1/1) intein C-terminal splicing region
PF14436 (1/1) Bacterial EndoU nuclease
PF13385 (1/1) Concanavalin A-like lectin/glucanases superfamily
PF07591 (1/1) Pretoxin HINT domain
PF00652 (1/1) Ricin-type beta-trefoil lectin domain
PF00561 (1/1) alpha/beta hydrolase fold

GCF_004195955.1

161.25 +- 0.00

0.01 +- 0.01

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00561 (1/1) alpha/beta hydrolase fold

GCF_003674045.1

2612.92 +- 1301.12

0.01 +- 0.01

PF07690 (2/3) Major Facilitator Superfamily
PF00067 (2/3) Cytochrome P450
PF00005 (2/3) ABC transporter

GCF_002803085.1

224.05 +- 0.00

0.01 +- 0.02

PF08445 (1/1) FR47-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF05076 (1/1) Suppressor of fused protein (SUFU)
PF04055 (1/1) Radical SAM superfamily
PF02310 (1/1) B12 binding domain

GCF_001270505.1

572.85 +- 77.15

0.04 +- 0.11

GCF_001279625.1

216.67 +- 0.00

0.01 +- 0.01

PF13459 (1/1) 4Fe-4S single cluster domain
PF10589 (1/1) NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
PF08386 (1/1) TAP-like protein
PF03640 (1/1) Secreted repeat of unknown function
PF01512 (1/1) Respiratory-chain NADH dehydrogenase 51 Kd subunit
PF00561 (1/1) alpha/beta hydrolase fold

GCF_000721935.1

118.18 +- 0.00

0.03 +- 0.05

PF01738 (1/1) Dienelactone hydrolase family
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00156 (1/1) Phosphoribosyl transferase domain
PF00005 (1/1) ABC transporter

GCF_002556545.1

598.31 +- 470.74

0.02 +- 0.04

PF04055 (3/5) Radical SAM superfamily

GCF_001751365.1

114.67 +- 0.00

0.03 +- 0.03

PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain

GCF_002028425.1

200.91 +- 0.00

0.07 +- 0.16

PF13641 (1/1) Glycosyltransferase like family 2
PF10823 (1/1) Protein of unknown function (DUF2568)
PF09335 (1/1) SNARE associated Golgi protein
PF07690 (1/1) Major Facilitator Superfamily
PF05721 (1/1) Phytanoyl-CoA dioxygenase (PhyH)
PF01810 (1/1) LysE type translocator
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain
PF00925 (1/1) GTP cyclohydrolase II
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00400 (1/1) WD domain, G-beta repeat
PF00067 (1/1) Cytochrome P450

GCF_000719035.1

30.35 +- 0.00

0.07 +- 0.06

PF13385 (1/1) Concanavalin A-like lectin/glucanases superfamily
PF08386 (1/1) TAP-like protein
PF07691 (1/1) PA14 domain
PF02837 (1/1) Glycosyl hydrolases family 2, sugar binding domain
PF00703 (1/1) Glycosyl hydrolases family 2
PF00561 (1/1) alpha/beta hydrolase fold

GCF_900215615.1

582.26 +- 501.25

0.04 +- 0.08

PF00005 (3/4) ABC transporter
PF01061 (2/4) ABC-2 type transporter

GCF_001672315.1

230.36 +- 0.00

0.07 +- 0.18

TIGR01733 (1/1) amino acid adenylation domain
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13560 (1/1) Helix-turn-helix domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF06368 (1/1) Methylaspartate mutase E chain (MutE)
PF03621 (1/1) MbtH-like protein
PF02784 (1/1) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF02310 (1/1) B12 binding domain
PF02222 (1/1) ATP-grasp domain
PF01645 (1/1) Conserved region in glutamate synthase
PF00975 (1/1) Thioesterase domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00152 (1/1) tRNA synthetases class II (D, K and N)

GCF_000716945.1

339.13 +- 0.00

0.03 +- 0.03

GCF_000718815.1

57.78 +- 0.00

0.05 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_000718835.1

42.62 +- 5.76

0.06 +- 0.00

PF13471 (1/2) Transglutaminase-like superfamily
PF12833 (1/2) Helix-turn-helix domain
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF02311 (1/2) AraC-like ligand binding domain
PF00733 (1/2) Asparagine synthase
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)

GCF_003122345.2

189.09 +- 0.00

0.04 +- 0.10

GCF_001427565.1

227.04 +- 0.00

0.02 +- 0.01

GCF_002155765.1

1290.00 +- 0.00

0.01 +- 0.00

PF16353 (1/1) Domain of unknown function(DUF4981)
PF14310 (1/1) Fibronectin type III-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF02929 (1/1) Beta galactosidase small chain
PF02837 (1/1) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/1) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (1/1) Glycosyl hydrolase family 3 C-terminal domain
PF00933 (1/1) Glycosyl hydrolase family 3 N terminal domain
PF00232 (1/1) Glycosyl hydrolase family 1

GCF_000707945.1

206.94 +- 111.08

0.03 +- 0.02

No common domains found

GCF_003122365.1

1341.60 +- 0.00

0.01 +- 0.01

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family

GCF_900236475.1

278.92 +- 237.08

0.06 +- 0.14

TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF11239 (1/2) Protein of unknown function (DUF3040)
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/2) Major Facilitator Superfamily
PF04203 (1/2) Sortase domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02610 (1/2) L-arabinose isomerase
PF00999 (1/2) Sodium/hydrogen exchanger family
PF00975 (1/2) Thioesterase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain

GCF_000225525.1

272.63 +- 116.63

0.03 +- 0.05

TIGR01554 (1/2) phage major capsid protein, HK97 family
TIGR01543 (1/2) phage prohead protease, HK97 family
TIGR01537 (1/2) phage portal protein, HK97 family
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13560 (1/2) Helix-turn-helix domain
PF13378 (1/2) Enolase C-terminal domain-like
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (1/2) FCD domain
PF05065 (1/2) Phage capsid family
PF04860 (1/2) Phage portal protein
PF04586 (1/2) Caudovirus prohead serine protease
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/2) Melibiase
PF01844 (1/2) HNH endonuclease
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF01081 (1/2) KDPG and KHG aldolase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase

GCF_001507395.1

57.78 +- 0.00

0.05 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_002941025.1

351.82 +- 0.00

0.02 +- 0.02

PF17996 (1/1) Carbohydrate esterase 2 N-terminal
PF17479 (1/1) Protein of unknown function (DUF3048) C-terminal domain
PF13472 (1/1) GDSL-like Lipase/Acylhydrolase family
PF11258 (1/1) Protein of unknown function (DUF3048) N-terminal domain
PF05988 (1/1) Bacterial protein of unknown function (DUF899)
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily

GCF_004195965.1

229.59 +- 166.98

0.06 +- 0.09

No common domains found

GCF_000297155.2

212.98 +- 0.00

0.03 +- 0.01

TIGR04469 (1/1) CGA synthase-related protein
TIGR04468 (1/1) arginine 2,3-aminomutase
TIGR04467 (1/1) hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
TIGR04466 (1/1) cytosylglucuronate decarboxylase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF08241 (1/1) Methyltransferase domain
PF05014 (1/1) Nucleoside 2-deoxyribosyltransferase
PF04055 (1/1) Radical SAM superfamily
PF01433 (1/1) Peptidase family M1 domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family

GCF_002754555.1

655.84 +- 540.10

0.04 +- 0.06

PF07690 (2/3) Major Facilitator Superfamily
PF00528 (2/3) Binding-protein-dependent transport system inner membrane component

GCF_000972395.1

61.92 +- 0.00

0.05 +- 0.07

PF11303 (1/1) Protein of unknown function (DUF3105)
PF09335 (1/1) SNARE associated Golgi protein
PF02388 (1/1) FemAB family
PF00507 (1/1) NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

GCF_000258595.1

258.00 +- 0.00

0.01 +- 0.00

PF00296 (1/1) Luciferase-like monooxygenase
PF00069 (1/1) Protein kinase domain

GCF_002155895.1

67.89 +- 0.00

0.07 +- 0.07

PF13671 (1/1) AAA domain
PF13649 (1/1) Methyltransferase domain
PF01427 (1/1) D-ala-D-ala dipeptidase
PF01425 (1/1) Amidase
PF00293 (1/1) NUDIX domain
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter

GCF_003097515.1

2408.00 +- 0.00

0.01 +- 0.00

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_900105705.1

94.29 +- 0.00

0.10 +- 0.22

TIGR00589 (1/1) methylated-DNA--[protein]-cysteine S-methyltransferase
PF13532 (1/1) 2OG-Fe(II) oxygenase superfamily
PF12728 (1/1) Helix-turn-helix domain
PF12307 (1/1) Protein of unknown function (DUF3631)
PF10935 (1/1) Protein of unknown function (DUF2637)
PF09250 (1/1) Bifunctional DNA primase/polymerase, N-terminal
PF04461 (1/1) Protein of unknown function (DUF520)
PF01035 (1/1) 6-O-methylguanine DNA methyltransferase, DNA binding domain
PF00589 (1/1) Phage integrase family
PF00145 (1/1) C-5 cytosine-specific DNA methylase

GCF_003949805.1

239.30 +- 0.00

0.03 +- 0.05

TIGR02124 (1/1) hydrogenase expression/formation protein HypE
TIGR01891 (1/1) amidohydrolase
TIGR00709 (1/1) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (1/1) carbamoyltransferase HypF
PF17788 (1/1) HypF Kae1-like domain
PF13671 (1/1) AAA domain
PF13535 (1/1) ATP-grasp domain
PF12680 (1/1) SnoaL-like domain
PF07690 (1/1) Major Facilitator Superfamily
PF07503 (1/1) HypF finger
PF05977 (1/1) Transmembrane secretion effector
PF02769 (1/1) AIR synthase related protein, C-terminal domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01300 (1/1) Telomere recombination
PF00857 (1/1) Isochorismatase family
PF00708 (1/1) Acylphosphatase
PF00586 (1/1) AIR synthase related protein, N-terminal domain
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00202 (1/1) Aminotransferase class-III
PF00155 (1/1) Aminotransferase class I and II

GCF_000952035.2

397.18 +- 430.60

0.03 +- 0.04

No common domains found

GCF_001005295.1

2686.03 +- 3671.47

0.03 +- 0.08

No common domains found

GCF_002114215.1

302.73 +- 109.23

0.02 +- 0.02

TIGR02103 (1/2) alpha-1,6-glucosidases, pullulanase-type
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF17967 (1/2) Pullulanase N2 domain
PF11852 (1/2) Domain of unknown function (DUF3372)
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF06964 (1/2) Alpha-L-arabinofuranosidase C-terminal domain
PF03881 (1/2) Fructosamine kinase
PF03714 (1/2) Bacterial pullanase-associated domain
PF02922 (1/2) Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
PF02806 (1/2) Alpha amylase, C-terminal all-beta domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01356 (1/2) Alpha amylase inhibitor
PF00892 (1/2) EamA-like transporter family
PF00686 (1/2) Starch binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00128 (1/2) Alpha amylase, catalytic domain
PF00106 (1/2) short chain dehydrogenase

GCF_000721265.1

680.41 +- 524.06

0.01 +- 0.02

No common domains found

GCF_001418335.1

175.19 +- 0.00

0.06 +- 0.09

TIGR01207 (1/1) glucose-1-phosphate thymidylyltransferase
TIGR01181 (1/1) dTDP-glucose 4,6-dehydratase
PF16363 (1/1) GDP-mannose 4,6 dehydratase
PF12833 (1/1) Helix-turn-helix domain
PF07690 (1/1) Major Facilitator Superfamily
PF05141 (1/1) Pyoverdine/dityrosine biosynthesis protein
PF03559 (1/1) NDP-hexose 2,3-dehydratase
PF01965 (1/1) DJ-1/PfpI family
PF01370 (1/1) NAD dependent epimerase/dehydratase family
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00908 (1/1) dTDP-4-dehydrorhamnose 3,5-epimerase
PF00483 (1/1) Nucleotidyl transferase
PF00067 (1/1) Cytochrome P450

GCF_001278075.1

206.93 +- 168.14

0.04 +- 0.03

No common domains found

GCF_000720475.1

58.74 +- 21.88

0.07 +- 0.11

PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF03483 (1/2) B3/4 domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01810 (1/2) LysE type translocator
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00246 (1/2) Zinc carboxypeptidase

GCF_000720715.1

73.80 +- 12.86

0.06 +- 0.06

GCF_000092385.1

326.87 +- 292.66

0.06 +- 0.15

No common domains found

GCF_003454755.1

180.37 +- 192.21

0.03 +- 0.06

TIGR01509 (2/3) HAD hydrolase, family IA, variant 3
PF13419 (2/3) Haloacid dehalogenase-like hydrolase

GCF_001541145.1

330.53 +- 436.11

0.03 +- 0.03

TIGR03945 (2/4) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (2/4) 2,3-diaminopropionate biosynthesis protein SbnB
PF02423 (2/4) Ornithine cyclodeaminase/mu-crystallin family
PF00291 (2/4) Pyridoxal-phosphate dependent enzyme

GCF_004123705.1

110.57 +- 0.00

0.04 +- 0.04

PF13517 (1/1) Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
PF05099 (1/1) Tellurite resistance protein TerB
PF00106 (1/1) short chain dehydrogenase
PF00089 (1/1) Trypsin

GCF_000717735.1

397.05 +- 424.35

0.04 +- 0.05

No common domains found

GCF_000158915.1

135.90 +- 63.64

0.06 +- 0.08

PF00583 (2/3) Acetyltransferase (GNAT) family
PF00171 (2/3) Aldehyde dehydrogenase family

GCF_000725645.1

75.51 +- 0.00

0.05 +- 0.03

TIGR00745 (1/1) 2-dehydropantoate 2-reductase
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13412 (1/1) Winged helix-turn-helix DNA-binding
PF13404 (1/1) AsnC-type helix-turn-helix domain
PF08546 (1/1) Ketopantoate reductase PanE/ApbA C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF02558 (1/1) Ketopantoate reductase PanE/ApbA
PF01546 (1/1) Peptidase family M20/M25/M40
PF01522 (1/1) Polysaccharide deacetylase
PF01037 (1/1) Lrp/AsnC ligand binding domain

GCF_002286695.1

645.00 +- 0.00

0.01 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF01135 (1/1) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
PF00733 (1/1) Asparagine synthase

GCF_001879105.1

86.00 +- 0.00

0.02 +- 0.02

PF18029 (1/1) Glyoxalase-like domain
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF01636 (1/1) Phosphotransferase enzyme family

GCF_000331005.1

245.82 +- 85.25

0.04 +- 0.04

PF07690 (3/6) Major Facilitator Superfamily

GCF_000721255.1

1872.00 +- 1560.00

0.01 +- 0.01

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02462 (1/2) pyranose oxidase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13601 (1/2) Winged helix DNA-binding domain
PF12698 (1/2) ABC-2 family transporter protein
PF07690 (1/2) Major Facilitator Superfamily
PF05199 (1/2) GMC oxidoreductase
PF03928 (1/2) Haem-degrading
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/2) Nitroreductase family
PF00732 (1/2) GMC oxidoreductase
PF00005 (1/2) ABC transporter

GCF_000802245.2

650.00 +- 0.00

0.01 +- 0.00

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/1) CPBP intramembrane metalloprotease
PF00881 (1/1) Nitroreductase family
PF00296 (1/1) Luciferase-like monooxygenase

GCF_001426405.1

470.80 +- 499.46

0.03 +- 0.03

No common domains found

GCF_003751425.1

429.97 +- 558.69

0.04 +- 0.14

PF18130 (2/4) ATP-grasp N-terminal domain
PF13535 (2/4) ATP-grasp domain
PF07690 (2/4) Major Facilitator Superfamily

GCF_000720485.1

216.67 +- 0.00

0.01 +- 0.00

TIGR00268 (1/1) TIGR00268 family protein
PF13620 (1/1) Carboxypeptidase regulatory-like domain
PF09861 (1/1) Lactate racemase N-terminal domain
PF04264 (1/1) YceI-like domain
PF00733 (1/1) Asparagine synthase
PF00731 (1/1) AIR carboxylase
PF00083 (1/1) Sugar (and other) transporter

GCF_900091785.1

23.64 +- 0.00

0.08 +- 0.07

GCF_000719185.1

54.36 +- 10.14

0.05 +- 0.02

GCF_000719705.1

183.65 +- 124.34

0.04 +- 0.03

No common domains found

GCF_003384795.1

860.00 +- 0.00

0.01 +- 0.01

TIGR02814 (1/1) PfaD family protein
TIGR02813 (1/1) polyketide-type polyunsaturated fatty acid synthase PfaA
PF18328 (1/1) Fatty acid synthase subunit PfaD N-terminal domain
PF16197 (1/1) Ketoacyl-synthetase C-terminal extension
PF14765 (1/1) Polyketide synthase dehydratase
PF12833 (1/1) Helix-turn-helix domain
PF08659 (1/1) KR domain
PF07977 (1/1) FabA-like domain
PF03060 (1/1) Nitronate monooxygenase
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02311 (1/1) AraC-like ligand binding domain
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
PF01593 (1/1) Flavin containing amine oxidoreductase
PF00975 (1/1) Thioesterase domain
PF00698 (1/1) Acyl transferase domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain

GCF_003253495.1

290.27 +- 109.67

0.05 +- 0.14

No common domains found

GCF_003270085.1

1806.00 +- 0.00

0.01 +- 0.00

PF14759 (1/1) Reductase C-terminal
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF09339 (1/1) IclR helix-turn-helix domain
PF09084 (1/1) NMT1/THI5 like
PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF01614 (1/1) Bacterial transcriptional regulator
PF01494 (1/1) FAD binding domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00171 (1/1) Aldehyde dehydrogenase family
PF00111 (1/1) 2Fe-2S iron-sulfur cluster binding domain
PF00005 (1/1) ABC transporter

GCF_000725635.1

29.77 +- 0.00

0.07 +- 0.02

GCF_001418585.1

1127.56 +- 595.63

0.01 +- 0.01

No common domains found

GCF_000718695.1

189.85 +- 0.00

0.03 +- 0.02

GCF_001280005.1

825.60 +- 0.00

0.02 +- 0.03

PF13333 (1/1) Integrase core domain
PF12146 (1/1) Serine aminopeptidase, S33
PF02909 (1/1) Tetracyclin repressor-like, C-terminal domain
PF02737 (1/1) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF01494 (1/1) FAD binding domain
PF00725 (1/1) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00665 (1/1) Integrase core domain
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00144 (1/1) Beta-lactamase

GCF_900090065.1

110.69 +- 13.19

0.06 +- 0.05

GCF_000719255.1

642.52 +- 496.13

0.02 +- 0.03

PF00550 (2/4) Phosphopantetheine attachment site
PF00005 (2/4) ABC transporter

GCF_001270635.1

469.97 +- 629.91

0.06 +- 0.08

PF00528 (2/4) Binding-protein-dependent transport system inner membrane component

GCF_000383935.1

292.28 +- 94.72

0.07 +- 0.16

TIGR02144 (1/2) lysine biosynthesis enzyme LysX
TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR00761 (1/2) acetylglutamate kinase
PF16864 (1/2) Dimerisation domain
PF13847 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08443 (1/2) RimK-like ATP-grasp domain
PF08241 (1/2) Methyltransferase domain
PF08031 (1/2) Berberine and berberine like
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF07366 (1/2) SnoaL-like polyketide cyclase
PF06821 (1/2) Serine hydrolase
PF04389 (1/2) Peptidase family M28
PF03621 (1/2) MbtH-like protein
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02774 (1/2) Semialdehyde dehydrogenase, dimerisation domain
PF01565 (1/2) FAD binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01494 (1/2) FAD binding domain
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00891 (1/2) O-methyltransferase domain
PF00696 (1/2) Amino acid kinase family
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00067 (1/2) Cytochrome P450

GCF_000745715.1

330.79 +- 287.77

0.03 +- 0.02

No common domains found

GCF_001417775.1

189.36 +- 147.27

0.02 +- 0.03

No common domains found

GCF_001431765.1

798.98 +- 841.21

0.05 +- 0.09

PF00005 (2/3) ABC transporter

GCF_000719775.1

339.13 +- 0.00

0.03 +- 0.01

TIGR03249 (1/1) 5-dehydro-4-deoxyglucarate dehydratase
PF14588 (1/1) YjgF/chorismate_mutase-like, putative endoribonuclease
PF09084 (1/1) NMT1/THI5 like
PF01321 (1/1) Creatinase/Prolidase N-terminal domain
PF00701 (1/1) Dihydrodipicolinate synthetase family
PF00557 (1/1) Metallopeptidase family M24
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter

GCF_000725655.1

299.00 +- 91.00

0.01 +- 0.02

TIGR03891 (1/2) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF06628 (1/2) Catalase-related immune-responsive
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF01475 (1/2) Ferric uptake regulator family
PF00248 (1/2) Aldo/keto reductase family
PF00199 (1/2) Catalase

GCF_001189015.1

226.45 +- 163.55

0.03 +- 0.02

TIGR03620 (1/2) probable F420-dependent oxidoreductase, MSMEG_4141 family
TIGR01726 (1/2) amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family
TIGR01182 (1/2) 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
PF18565 (1/2) Glycoside hydrolase family 2 C-terminal domain 5
PF16355 (1/2) Domain of unknown function (DUF4982)
PF14310 (1/2) Fibronectin type III-like domain
PF02837 (1/2) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (1/2) Glycosyl hydrolases family 2, TIM barrel domain
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01522 (1/2) Polysaccharide deacetylase
PF01081 (1/2) KDPG and KHG aldolase
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00703 (1/2) Glycosyl hydrolases family 2
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00296 (1/2) Luciferase-like monooxygenase

GCF_000716625.1

389.15 +- 255.86

0.02 +- 0.04

No common domains found

GCF_001746295.1

91.42 +- 44.71

0.07 +- 0.05

No common domains found

GCF_001590865.1

523.98 +- 729.56

0.03 +- 0.09

No common domains found

GCF_900090145.1

84.13 +- 0.00

0.06 +- 0.07

PF07690 (1/1) Major Facilitator Superfamily
PF07158 (1/1) Dicarboxylate carrier protein MatC N-terminus
PF03033 (1/1) Glycosyltransferase family 28 N-terminal domain
PF02776 (1/1) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/1) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02515 (1/1) CoA-transferase family III
PF00932 (1/1) Lamin Tail Domain
PF00205 (1/1) Thiamine pyrophosphate enzyme, central domain

GCF_000719335.1

158.26 +- 101.74

0.06 +- 0.09

TIGR02957 (1/2) RNA polymerase sigma-70 factor, TIGR02957 family
PF18029 (1/2) Glyoxalase-like domain
PF08281 (1/2) Sigma-70, region 4
PF04542 (1/2) Sigma-70 region 2
PF04235 (1/2) Protein of unknown function (DUF418)
PF01965 (1/2) DJ-1/PfpI family
PF01738 (1/2) Dienelactone hydrolase family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00156 (1/2) Phosphoribosyl transferase domain

GCF_001270025.1

30.35 +- 0.00

0.07 +- 0.06

PF02515 (1/1) CoA-transferase family III
PF00583 (1/1) Acetyltransferase (GNAT) family

GCF_000719195.1

136.44 +- 57.06

0.04 +- 0.03

TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07690 (1/2) Major Facilitator Superfamily
PF07179 (1/2) SseB protein N-terminal domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00106 (1/2) short chain dehydrogenase

GCF_002155885.1

294.86 +- 0.00

0.01 +- 0.00

PF02838 (1/1) Glycosyl hydrolase family 20, domain 2
PF00754 (1/1) F5/8 type C domain
PF00728 (1/1) Glycosyl hydrolase family 20, catalytic domain

GCF_000716815.1

183.75 +- 189.95

0.05 +- 0.08

PF00501 (2/3) AMP-binding enzyme

GCF_001427745.1

704.54 +- 188.54

0.01 +- 0.00

PF13661 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13640 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13577 (1/2) SnoaL-like domain
PF08291 (1/2) Peptidase M15
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02310 (1/2) B12 binding domain
PF01471 (1/2) Putative peptidoglycan binding domain
PF00899 (1/2) ThiF family
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle

GCF_004195775.1

175.38 +- 0.00

0.07 +- 0.11

GCF_000377125.1

346.67 +- 173.33

0.01 +- 0.01

TIGR01733 (1/2) amino acid adenylation domain
PF18456 (1/2) Diiron non-heme beta-hydroxylase N-terminal domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13545 (1/2) Crp-like helix-turn-helix domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF07228 (1/2) Stage II sporulation protein E (SpoIIE)
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF01636 (1/2) Phosphotransferase enzyme family
PF00975 (1/2) Thioesterase domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00326 (1/2) Prolyl oligopeptidase family
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain
PF00027 (1/2) Cyclic nucleotide-binding domain

GCF_002954775.1

287.87 +- 288.65

0.04 +- 0.05

No common domains found

GCF_000720765.1

2228.54 +- 1567.40

0.02 +- 0.05

PF02771 (2/3) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (2/3) Acyl-CoA dehydrogenase, middle domain
PF00441 (2/3) Acyl-CoA dehydrogenase, C-terminal domain

GCF_000721945.1

432.53 +- 241.48

0.01 +- 0.01

PF09339 (2/3) IclR helix-turn-helix domain
PF01614 (2/3) Bacterial transcriptional regulator
PF00175 (2/3) Oxidoreductase NAD-binding domain
PF00111 (2/3) 2Fe-2S iron-sulfur cluster binding domain

GCF_000717015.1

173.48 +- 0.00

0.03 +- 0.02

GCF_001746285.1

136.40 +- 73.29

0.06 +- 0.06

No common domains found

GCF_003994375.1

105.22 +- 11.41

0.06 +- 0.08

PF07690 (2/2) Major Facilitator Superfamily
TIGR03975 (1/2) ribosomal peptide maturation radical SAM protein 1
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
PF13581 (1/2) Histidine kinase-like ATPase domain
PF10025 (1/2) Uncharacterized conserved protein (DUF2267)
PF08281 (1/2) Sigma-70, region 4
PF07681 (1/2) DoxX
PF04542 (1/2) Sigma-70 region 2
PF04055 (1/2) Radical SAM superfamily
PF02515 (1/2) CoA-transferase family III
PF02310 (1/2) B12 binding domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00355 (1/2) Rieske [2Fe-2S] domain
PF00326 (1/2) Prolyl oligopeptidase family
PF00067 (1/2) Cytochrome P450

GCF_002911015.1

359.11 +- 279.44

0.04 +- 0.15

PF11271 (1/2) Porin PorA
PF10502 (1/2) Signal peptidase, peptidase S26
PF10145 (1/2) Phage-related minor tail protein
PF06199 (1/2) Phage tail tube protein
PF04860 (1/2) Phage portal protein
PF04586 (1/2) Caudovirus prohead serine protease
PF03704 (1/2) Bacterial transcriptional activator domain
PF03237 (1/2) Terminase-like family
PF02018 (1/2) Carbohydrate binding domain
PF01844 (1/2) HNH endonuclease
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00931 (1/2) NB-ARC domain
PF00899 (1/2) ThiF family
PF00717 (1/2) Peptidase S24-like
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00005 (1/2) ABC transporter

GCF_900230275.1

179.81 +- 61.78

0.04 +- 0.07

PF03067 (2/4) Lytic polysaccharide mono-oxygenase, cellulose-degrading

GCF_000332625.1

69.59 +- 11.88

0.05 +- 0.10

No common domains found

GCF_001905405.1

504.94 +- 140.06

0.02 +- 0.02

GCF_002154605.1

248.51 +- 229.43

0.02 +- 0.02

PF05147 (2/4) Lanthionine synthetase C-like protein

GCF_001270585.1

167.02 +- 138.44

0.04 +- 0.05

No common domains found

GCF_001513975.1

949.55 +- 1479.35

0.03 +- 0.07

No common domains found

GCF_004195765.1

51.60 +- 0.00

0.04 +- 0.03

GCF_001418285.1

77.40 +- 0.00

0.08 +- 0.17

TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01686 (1/2) FkbH domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF07158 (1/2) Dicarboxylate carrier protein MatC N-terminus
PF03033 (1/2) Glycosyltransferase family 28 N-terminal domain
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02737 (1/2) 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
PF02515 (1/2) CoA-transferase family III
PF00975 (1/2) Thioesterase domain
PF00932 (1/2) Lamin Tail Domain
PF00725 (1/2) 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain

GCF_001279965.1

1671.43 +- 0.00

0.01 +- 0.01

GCF_900101975.1

211.75 +- 108.55

0.06 +- 0.16

TIGR01928 (1/2) o-succinylbenzoate synthase
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17676 (1/2) LD-carboxypeptidase C-terminal domain
PF17291 (1/2) N-terminal domain of M60-like peptidases
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13402 (1/2) Peptidase M60, enhancin and enhancin-like
PF13378 (1/2) Enolase C-terminal domain-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF12831 (1/2) FAD dependent oxidoreductase
PF10022 (1/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08124 (1/2) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF02884 (1/2) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02515 (1/2) CoA-transferase family III
PF02278 (1/2) Polysaccharide lyase family 8, super-sandwich domain
PF02016 (1/2) LD-carboxypeptidase N-terminal domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01381 (1/2) Helix-turn-helix
PF01380 (1/2) SIS domain
PF00701 (1/2) Dihydrodipicolinate synthetase family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00171 (1/2) Aldehyde dehydrogenase family
PF00005 (1/2) ABC transporter

GCF_900091725.1

161.20 +- 98.80

0.03 +- 0.04

PF13193 (2/2) AMP-binding enzyme C-terminal domain
PF00501 (2/2) AMP-binding enzyme
TIGR04020 (1/2) natural product biosynthesis luciferase-like monooxygenase domain
TIGR01733 (1/2) amino acid adenylation domain
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13181 (1/2) Tetratricopeptide repeat
PF07690 (1/2) Major Facilitator Superfamily
PF02801 (1/2) Beta-ketoacyl synthase, C-terminal domain
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00578 (1/2) AhpC/TSA family
PF00550 (1/2) Phosphopantetheine attachment site
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00109 (1/2) Beta-ketoacyl synthase, N-terminal domain

GCF_000158955.1

365.16 +- 190.80

0.03 +- 0.04

PF00005 (2/4) ABC transporter

GCF_003945505.1

336.90 +- 316.88

0.03 +- 0.03

No common domains found

GCF_000717345.1

558.54 +- 373.93

0.07 +- 0.15

PF03992 (2/3) Antibiotic biosynthesis monooxygenase
PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter

GCF_900105775.1

296.59 +- 193.16

0.05 +- 0.14

PF00005 (2/3) ABC transporter

GCF_900105755.1

173.33 +- 0.00

0.02 +- 0.02

PF13602 (1/1) Zinc-binding dehydrogenase
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07702 (1/1) UTRA domain
PF03747 (1/1) ADP-ribosylglycohydrolase
PF02133 (1/1) Permease for cytosine/purines, uracil, thiamine, allantoin
PF00582 (1/1) Universal stress protein family
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase

GCF_000414115.1

310.73 +- 0.00

0.02 +- 0.02

PF13560 (1/1) Helix-turn-helix domain
PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF01546 (1/1) Peptidase family M20/M25/M40
PF01381 (1/1) Helix-turn-helix
PF00733 (1/1) Asparagine synthase
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00005 (1/1) ABC transporter

GCF_001513965.1

1092.95 +- 1241.10

0.02 +- 0.04

PF13393 (2/3) Histidyl-tRNA synthetase

GCF_003435025.1

384.84 +- 203.16

0.04 +- 0.06

No common domains found

GCF_003751445.1

143.05 +- 0.00

0.06 +- 0.17

TIGR03026 (1/1) nucleotide sugar dehydrogenase
TIGR01733 (1/1) amino acid adenylation domain
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF13469 (1/1) Sulfotransferase family
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF07690 (1/1) Major Facilitator Superfamily
PF03721 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02615 (1/1) Malate/L-lactate dehydrogenase
PF01522 (1/1) Polysaccharide deacetylase
PF01408 (1/1) Oxidoreductase family, NAD-binding Rossmann fold
PF01261 (1/1) Xylose isomerase-like TIM barrel
PF00984 (1/1) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_002848525.1

258.00 +- 0.00

0.06 +- 0.04

PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF12679 (1/1) ABC-2 family transporter protein
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (1/1) Beta-ketoacyl synthase, C-terminal domain
PF01144 (1/1) Coenzyme A transferase
PF00378 (1/1) Enoyl-CoA hydratase/isomerase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00109 (1/1) Beta-ketoacyl synthase, N-terminal domain
PF00106 (1/1) short chain dehydrogenase
PF00005 (1/1) ABC transporter

GCF_001426325.1

283.80 +- 0.00

0.01 +- 0.01

GCF_000720755.1

166.54 +- 0.00

0.08 +- 0.06

TIGR01409 (1/1) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (1/1) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (1/1) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/1) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (1/1) Alpha galactosidase A
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/1) Enolase C-terminal domain-like
PF08450 (1/1) SMP-30/Gluconolactonase/LRE-like region
PF07729 (1/1) FCD domain
PF02746 (1/1) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/1) Melibiase
PF01547 (1/1) Bacterial extracellular solute-binding protein
PF01081 (1/1) KDPG and KHG aldolase
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00392 (1/1) Bacterial regulatory proteins, gntR family
PF00294 (1/1) pfkB family carbohydrate kinase

GCF_002777535.1

108.43 +- 35.18

0.05 +- 0.08

No common domains found

GCF_001652895.1

210.91 +- 113.50

0.04 +- 0.04

PF07690 (4/4) Major Facilitator Superfamily

GCF_000721455.1

1593.53 +- 0.00

0.03 +- 0.02

GCF_003205575.1

455.00 +- 0.00

0.04 +- 0.04

TIGR01733 (1/1) amino acid adenylation domain
PF18563 (1/1) TubC N-terminal docking domain
PF16653 (1/1) Saccharopine dehydrogenase C-terminal domain
PF14518 (1/1) Iron-containing redox enzyme
PF13714 (1/1) Phosphoenolpyruvate phosphomutase
PF13535 (1/1) ATP-grasp domain
PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring)
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09334 (1/1) tRNA synthetases class I (M)
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF05222 (1/1) Alanine dehydrogenase/PNT, N-terminal domain
PF03435 (1/1) Saccharopine dehydrogenase NADP binding domain
PF03417 (1/1) Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF01648 (1/1) 4'-phosphopantetheinyl transferase superfamily
PF01266 (1/1) FAD dependent oxidoreductase
PF00975 (1/1) Thioesterase domain
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00067 (1/1) Cytochrome P450

GCF_002705725.1

1337.14 +- 0.00

0.02 +- 0.01

TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR01307 (1/1) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF13549 (1/1) ATP-grasp domain
PF13535 (1/1) ATP-grasp domain
PF13480 (1/1) Acetyltransferase (GNAT) domain
PF13115 (1/1) YtkA-like
PF04389 (1/1) Peptidase family M28
PF02627 (1/1) Carboxymuconolactone decarboxylase family
PF01676 (1/1) Metalloenzyme superfamily
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00664 (1/1) ABC transporter transmembrane region
PF00403 (1/1) Heavy-metal-associated domain
PF00275 (1/1) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/1) Aminotransferase class I and II
PF00122 (1/1) E1-E2 ATPase
PF00117 (1/1) Glutamine amidotransferase class-I
PF00005 (1/1) ABC transporter

GCF_002803065.1

125.51 +- 74.13

0.06 +- 0.10

No common domains found

GCF_003627815.1

703.64 +- 181.93

0.01 +- 0.00

No common domains found

GCF_003846185.1

686.34 +- 532.14

0.01 +- 0.01

PF00005 (2/4) ABC transporter

GCF_002154495.1

172.00 +- 0.00

0.01 +- 0.00

PF13649 (1/1) Methyltransferase domain
PF04672 (1/1) S-adenosyl methyltransferase

GCF_001751375.1

5794.29 +- 0.00

0.01 +- 0.00

GCF_003664315.1

516.00 +- 0.00

0.01 +- 0.00

TIGR04276 (1/1) FxsC C-terminal domain
TIGR04269 (1/1) radical SAM/SPASM domain protein, FxsB family
TIGR04268 (1/1) FXSXX-COOH protein
TIGR04267 (1/1) HEXXH motif domain
PF13676 (1/1) TIR domain
PF13424 (1/1) Tetratricopeptide repeat
PF13374 (1/1) Tetratricopeptide repeat
PF04055 (1/1) Radical SAM superfamily
PF01656 (1/1) CobQ/CobB/MinD/ParA nucleotide binding domain
PF00931 (1/1) NB-ARC domain

GCF_003013745.1

264.81 +- 0.00

0.04 +- 0.03

GCF_002261115.1

1328.22 +- 1250.88

0.01 +- 0.00

PF00005 (2/3) ABC transporter

GCF_001931635.1

173.33 +- 0.00

0.02 +- 0.02

TIGR00067 (1/1) glutamate racemase
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF07478 (1/1) D-ala D-ala ligase C-terminus
PF01820 (1/1) D-ala D-ala ligase N-terminus
PF01177 (1/1) Asp/Glu/Hydantoin racemase

GCF_900091735.1

401.33 +- 0.00

0.07 +- 0.23

PF13649 (1/1) Methyltransferase domain
PF13581 (1/1) Histidine kinase-like ATPase domain
PF13006 (1/1) Insertion element 4 transposase N-terminal
PF12730 (1/1) ABC-2 family transporter protein
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00465 (1/1) Iron-containing alcohol dehydrogenase
PF00296 (1/1) Luciferase-like monooxygenase
PF00202 (1/1) Aminotransferase class-III
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter

GCF_000720075.1

169.11 +- 87.11

0.04 +- 0.06

TIGR01496 (1/2) dihydropteroate synthase
TIGR01205 (1/2) D-alanine--D-alanine ligase
TIGR01082 (1/2) UDP-N-acetylmuramate--L-alanine ligase
PF08310 (1/2) LGFP repeat
PF08245 (1/2) Mur ligase middle domain
PF07995 (1/2) Glucose / Sorbosone dehydrogenase
PF07478 (1/2) D-ala D-ala ligase C-terminus
PF04101 (1/2) Glycosyltransferase family 28 C-terminal domain
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF03033 (1/2) Glycosyltransferase family 28 N-terminal domain
PF02875 (1/2) Mur ligase family, glutamate ligase domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF01820 (1/2) D-ala D-ala ligase N-terminus
PF01427 (1/2) D-ala-D-ala dipeptidase
PF01225 (1/2) Mur ligase family, catalytic domain
PF00809 (1/2) Pterin binding enzyme
PF00801 (1/2) PKD domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00218 (1/2) Indole-3-glycerol phosphate synthase
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_003610255.1

1401.11 +- 938.89

0.01 +- 0.01

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF14081 (1/2) Domain of unknown function (DUF4262)
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13400 (1/2) Putative Flp pilus-assembly TadE/G-like
PF08666 (1/2) SAF domain
PF07811 (1/2) TadE-like protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01476 (1/2) LysM domain
PF01381 (1/2) Helix-turn-helix
PF00881 (1/2) Nitroreductase family
PF00664 (1/2) ABC transporter transmembrane region
PF00482 (1/2) Type II secretion system (T2SS), protein F
PF00437 (1/2) Type II/IV secretion system protein
PF00364 (1/2) Biotin-requiring enzyme
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter

GCF_002591335.1

461.57 +- 543.29

0.04 +- 0.04

No common domains found

GCF_000719735.1

35.45 +- 0.00

0.08 +- 0.12

GCF_000829695.1

728.47 +- 0.00

0.02 +- 0.01

PF17914 (1/1) HopA1 effector protein family
PF13732 (1/1) Domain of unknown function (DUF4162)
PF13649 (1/1) Methyltransferase domain
PF12698 (1/1) ABC-2 family transporter protein
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00664 (1/1) ABC transporter transmembrane region
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00005 (1/1) ABC transporter

GCF_000981895.1

283.64 +- 0.00

0.01 +- 0.01

PF18135 (1/1) Type ISP C-terminal specificity domain
PF16656 (1/1) Purple acid Phosphatase, N-terminal domain
PF15646 (1/1) Restriction endonuclease fold toxin 2
PF02384 (1/1) N-6 DNA Methylase
PF00664 (1/1) ABC transporter transmembrane region
PF00149 (1/1) Calcineurin-like phosphoesterase
PF00005 (1/1) ABC transporter

GCF_003259275.1

328.70 +- 29.99

0.05 +- 0.15

No common domains found

GCF_900090125.1

101.58 +- 5.92

0.07 +- 0.09

GCF_000718715.1

73.80 +- 12.86

0.06 +- 0.06

GCF_000377105.1

473.00 +- 215.00

0.01 +- 0.00

GCF_003268535.1

258.00 +- 0.00

0.01 +- 0.00

PF18593 (1/1) CdiI immunity protein
PF18431 (1/1) Bacterial CdiA-CT RNAse A domain
PF13560 (1/1) Helix-turn-helix domain
PF06013 (1/1) Proteins of 100 residues with WXG
PF04149 (1/1) Domain of unknown function (DUF397)

GCF_001279095.1

44.23 +- 0.00

0.07 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_000373465.1

28.26 +- 0.00

0.07 +- 0.04

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF01042 (1/1) Endoribonuclease L-PSP
PF00144 (1/1) Beta-lactamase

GCF_900102095.1

1032.00 +- 0.00

0.01 +- 0.00

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF18029 (1/1) Glyoxalase-like domain
PF04055 (1/1) Radical SAM superfamily
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (1/1) CPBP intramembrane metalloprotease
PF00881 (1/1) Nitroreductase family
PF00296 (1/1) Luciferase-like monooxygenase

GCF_001888885.1

642.33 +- 610.97

0.03 +- 0.05

No common domains found

GCF_000956015.1

110.12 +- 0.00

0.07 +- 0.06

GCF_900105395.1

329.29 +- 169.24

0.03 +- 0.03

No common domains found

GCF_000718595.1

555.69 +- 39.69

0.01 +- 0.00

TIGR02124 (1/2) hydrogenase expression/formation protein HypE
TIGR01891 (1/2) amidohydrolase
TIGR00709 (1/2) 2,4-diaminobutyrate 4-transaminase
TIGR00143 (1/2) carbamoyltransferase HypF
PF17788 (1/2) HypF Kae1-like domain
PF13535 (1/2) ATP-grasp domain
PF12680 (1/2) SnoaL-like domain
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07690 (1/2) Major Facilitator Superfamily
PF07503 (1/2) HypF finger
PF05977 (1/2) Transmembrane secretion effector
PF04324 (1/2) BFD-like [2Fe-2S] binding domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02769 (1/2) AIR synthase related protein, C-terminal domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01300 (1/2) Telomere recombination
PF01266 (1/2) FAD dependent oxidoreductase
PF00857 (1/2) Isochorismatase family
PF00708 (1/2) Acylphosphatase
PF00586 (1/2) AIR synthase related protein, N-terminal domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00293 (1/2) NUDIX domain
PF00202 (1/2) Aminotransferase class-III
PF00155 (1/2) Aminotransferase class I and II

GCF_000725495.1

144.07 +- 107.30

0.06 +- 0.10

No common domains found

GCF_002846315.1

59.50 +- 18.47

0.07 +- 0.06

No common domains found

GCF_000375725.1

466.47 +- 53.53

0.02 +- 0.02

GCF_003389455.1

72.56 +- 0.00

0.04 +- 0.00

TIGR03668 (1/1) PPOX class probable F420-dependent enzyme, Rv0121 family
TIGR03619 (1/1) probable F420-dependent oxidoreductase, Rv2161c family
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF01243 (1/1) Pyridoxamine 5'-phosphate oxidase
PF00296 (1/1) Luciferase-like monooxygenase

GCF_000972385.1

210.60 +- 189.80

0.05 +- 0.05

PF12802 (1/2) MarR family
PF12680 (1/2) SnoaL-like domain
PF09084 (1/2) NMT1/THI5 like
PF01937 (1/2) Protein of unknown function DUF89
PF01483 (1/2) Proprotein convertase P-domain
PF01323 (1/2) DSBA-like thioredoxin domain
PF00753 (1/2) Metallo-beta-lactamase superfamily
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter

GCF_001189025.1

384.42 +- 157.38

0.02 +- 0.01

TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF12146 (1/2) Serine aminopeptidase, S33
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07366 (1/2) SnoaL-like polyketide cyclase
PF07179 (1/2) SseB protein N-terminal domain
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04978 (1/2) Protein of unknown function (DUF664)
PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_002081495.1

101.74 +- 0.00

0.03 +- 0.05

PF13480 (1/1) Acetyltransferase (GNAT) domain
PF02156 (1/1) Glycosyl hydrolase family 26
PF01522 (1/1) Polysaccharide deacetylase
PF00535 (1/1) Glycosyl transferase family 2

GCF_001445835.1

23.45 +- 0.00

0.09 +- 0.07

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF08241 (1/1) Methyltransferase domain
PF00753 (1/1) Metallo-beta-lactamase superfamily

GCF_000720065.1

135.20 +- 0.00

0.04 +- 0.03

GCF_000718155.1

1002.14 +- 120.69

0.02 +- 0.04

PF13649 (2/3) Methyltransferase domain
PF05193 (2/3) Peptidase M16 inactive domain
PF00675 (2/3) Insulinase (Peptidase family M16)
PF00005 (2/3) ABC transporter

GCF_001866665.1

202.22 +- 57.78

0.02 +- 0.03

TIGR01733 (1/2) amino acid adenylation domain
TIGR01509 (1/2) HAD hydrolase, family IA, variant 3
PF14681 (1/2) Uracil phosphoribosyltransferase
PF14027 (1/2) Questin oxidase-like
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF11303 (1/2) Protein of unknown function (DUF3105)
PF09286 (1/2) Pro-kumamolisin, activation domain
PF07690 (1/2) Major Facilitator Superfamily
PF04227 (1/2) Indigoidine synthase A like protein
PF03713 (1/2) Domain of unknown function (DUF305)
PF01361 (1/2) Tautomerase enzyme
PF00975 (1/2) Thioesterase domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00082 (1/2) Subtilase family

GCF_003344445.1

803.96 +- 685.80

0.04 +- 0.09

PF17914 (2/4) HopA1 effector protein family
PF01636 (2/4) Phosphotransferase enzyme family
PF00664 (2/4) ABC transporter transmembrane region
PF00005 (2/4) ABC transporter

GCF_000701285.1

812.50 +- 472.09

0.01 +- 0.01

PF00528 (2/4) Binding-protein-dependent transport system inner membrane component

GCF_000818195.1

490.74 +- 594.82

0.05 +- 0.08

No common domains found

GCF_003675955.1

378.81 +- 238.69

0.03 +- 0.09

PF09339 (2/3) IclR helix-turn-helix domain
PF07690 (2/3) Major Facilitator Superfamily
PF01614 (2/3) Bacterial transcriptional regulator

GCF_000721445.1

606.67 +- 0.00

0.01 +- 0.00

PF17914 (1/1) HopA1 effector protein family
PF02441 (1/1) Flavoprotein
PF01636 (1/1) Phosphotransferase enzyme family
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00664 (1/1) ABC transporter transmembrane region
PF00535 (1/1) Glycosyl transferase family 2
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_000993785.2

309.30 +- 382.11

0.07 +- 0.10

No common domains found

GCF_000700005.2

153.06 +- 9.30

0.06 +- 0.09

PF13419 (2/3) Haloacid dehalogenase-like hydrolase

GCF_000720185.1

520.00 +- 0.00

0.01 +- 0.00

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/1) SagB-type dehydrogenase domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00067 (1/1) Cytochrome P450

GCF_001746415.1

1508.05 +- 1314.81

0.02 +- 0.04

PF00005 (2/2) ABC transporter
TIGR01263 (1/2) 4-hydroxyphenylpyruvate dioxygenase
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00652 (1/2) diaminopimelate epimerase
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF14518 (1/2) Iron-containing redox enzyme
PF14226 (1/2) non-haem dioxygenase in morphine synthesis N-terminal
PF13535 (1/2) ATP-grasp domain
PF13458 (1/2) Periplasmic binding protein
PF12399 (1/2) Branched-chain amino acid ATP-binding cassette transporter
PF10014 (1/2) 2OG-Fe dioxygenase
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08241 (1/2) Methyltransferase domain
PF07859 (1/2) alpha/beta hydrolase fold
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF05195 (1/2) Aminopeptidase P, N-terminal domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF03328 (1/2) HpcH/HpaI aldolase/citrate lyase family
PF03171 (1/2) 2OG-Fe(II) oxygenase superfamily
PF02653 (1/2) Branched-chain amino acid transport system / permease component
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF02153 (1/2) Prephenate dehydrogenase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01678 (1/2) Diaminopimelate epimerase
PF01575 (1/2) MaoC like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01497 (1/2) Periplasmic binding protein
PF01425 (1/2) Amidase
PF01070 (1/2) FMN-dependent dehydrogenase
PF01032 (1/2) FecCD transport family
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00892 (1/2) EamA-like transporter family
PF00682 (1/2) HMGL-like
PF00664 (1/2) ABC transporter transmembrane region
PF00557 (1/2) Metallopeptidase family M24
PF00384 (1/2) Molybdopterin oxidoreductase
PF00248 (1/2) Aldo/keto reductase family
PF00155 (1/2) Aminotransferase class I and II

GCF_001514125.1

645.00 +- 0.00

0.01 +- 0.00

TIGR04085 (1/1) radical SAM additional 4Fe4S-binding SPASM domain
PF13186 (1/1) Iron-sulfur cluster-binding domain
PF08241 (1/1) Methyltransferase domain
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF01980 (1/1) tRNA-methyltransferase O
PF01494 (1/1) FAD binding domain

GCF_000373685.1

130.00 +- 0.00

0.02 +- 0.00

TIGR02532 (1/1) prepilin-type N-terminal cleavage/methylation domain
PF07963 (1/1) Prokaryotic N-terminal methylation motif
PF06750 (1/1) Bacterial Peptidase A24 N-terminal domain
PF03551 (1/1) Transcriptional regulator PadR-like family
PF01478 (1/1) Type IV leader peptidase family

GCF_001550325.1

196.81 +- 147.19

0.04 +- 0.03

GCF_001949645.1

355.86 +- 0.00

0.08 +- 0.23

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13560 (1/1) Helix-turn-helix domain
PF13535 (1/1) ATP-grasp domain
PF10901 (1/1) Protein of unknown function (DUF2690)
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01471 (1/1) Putative peptidoglycan binding domain
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00664 (1/1) ABC transporter transmembrane region
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain
PF00005 (1/1) ABC transporter

GCF_003709145.1

266.32 +- 0.00

0.03 +- 0.01

TIGR00976 (1/1) hydrolase CocE/NonD family protein
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07859 (1/1) alpha/beta hydrolase fold
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF02126 (1/1) Phosphotriesterase family
PF01494 (1/1) FAD binding domain
PF00753 (1/1) Metallo-beta-lactamase superfamily
PF00440 (1/1) Bacterial regulatory proteins, tetR family

GCF_900188405.1

910.00 +- 650.00

0.01 +- 0.00

TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF17912 (1/2) MalK OB fold domain
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08402 (1/2) TOBE domain
PF02615 (1/2) Malate/L-lactate dehydrogenase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00465 (1/2) Iron-containing alcohol dehydrogenase
PF00171 (1/2) Aldehyde dehydrogenase family
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter

GCF_003675325.1

458.05 +- 32.60

0.03 +- 0.02

PF07690 (2/2) Major Facilitator Superfamily
TIGR04444 (1/2) chorismatase, FkbO/Hyg5 family
TIGR01902 (1/2) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/2) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/2) alpha-L-glutamate ligase, RimK family
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF17645 (1/2) Arylmalonate decarboxylase
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12802 (1/2) MarR family
PF08443 (1/2) RimK-like ATP-grasp domain
PF06339 (1/2) Ectoine synthase
PF03992 (1/2) Antibiotic biosynthesis monooxygenase
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF01841 (1/2) Transglutaminase-like superfamily
PF01546 (1/2) Peptidase family M20/M25/M40
PF01474 (1/2) Class-II DAHP synthetase family
PF01370 (1/2) NAD dependent epimerase/dehydratase family
PF01118 (1/2) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/2) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/2) Amino acid kinase family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00456 (1/2) Transketolase, thiamine diphosphate binding domain
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase

GCF_003752655.1

737.70 +- 765.25

0.02 +- 0.06

No common domains found

GCF_900090115.1

741.09 +- 650.13

0.02 +- 0.02

PF07690 (3/4) Major Facilitator Superfamily
PF13649 (2/4) Methyltransferase domain
PF00005 (2/4) ABC transporter

GCF_001426425.1

50.00 +- 0.00

0.04 +- 0.03

PF12802 (1/1) MarR family
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF00724 (1/1) NADH:flavin oxidoreductase / NADH oxidase family
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_900114955.1

648.69 +- 644.60

0.03 +- 0.04

PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter

GCF_004023625.1

406.92 +- 213.38

0.02 +- 0.03

No common domains found

GCF_900103985.1

43.33 +- 0.00

0.05 +- 0.04

PF00171 (1/1) Aldehyde dehydrogenase family
PF00106 (1/1) short chain dehydrogenase

GCF_003814935.1

368.63 +- 170.25

0.02 +- 0.03

No common domains found

GCF_003259625.1

520.00 +- 0.00

0.01 +- 0.00

TIGR04085 (1/1) radical SAM additional 4Fe4S-binding SPASM domain
PF07690 (1/1) Major Facilitator Superfamily
PF04055 (1/1) Radical SAM superfamily
PF02441 (1/1) Flavoprotein
PF02310 (1/1) B12 binding domain

GCF_900079405.2

79.05 +- 41.68

0.04 +- 0.04

No common domains found

GCF_003999195.1

1243.71 +- 873.82

0.03 +- 0.15

No common domains found

GCF_000931445.1

790.65 +- 672.18

0.02 +- 0.03

PF17914 (2/3) HopA1 effector protein family
PF02441 (2/3) Flavoprotein
PF00296 (2/3) Luciferase-like monooxygenase

GCF_900091715.1

834.17 +- 0.00

0.01 +- 0.00

TIGR01891 (1/1) amidohydrolase
TIGR01821 (1/1) 5-aminolevulinic acid synthase
PF16884 (1/1) N-terminal domain of oxidoreductase
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07690 (1/1) Major Facilitator Superfamily
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01546 (1/1) Peptidase family M20/M25/M40
PF00155 (1/1) Aminotransferase class I and II
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_000716435.1

333.11 +- 358.32

0.02 +- 0.02

No common domains found

GCF_001280045.1

387.00 +- 0.00

0.01 +- 0.00

TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus

GCF_000245355.1

457.94 +- 727.00

0.06 +- 0.07

No common domains found

GCF_000720565.1

223.88 +- 134.85

0.03 +- 0.02

No common domains found

GCF_002024165.1

205.40 +- 184.60

0.02 +- 0.03

TIGR03328 (1/2) methylthioribulose-1-phosphate dehydratase
TIGR00512 (1/2) S-methyl-5-thioribose-1-phosphate isomerase
PF11259 (1/2) Protein of unknown function (DUF3060)
PF04055 (1/2) Radical SAM superfamily
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02310 (1/2) B12 binding domain
PF01522 (1/2) Polysaccharide deacetylase
PF01008 (1/2) Initiation factor 2 subunit family
PF00596 (1/2) Class II Aldolase and Adducin N-terminal domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain

GCF_002021875.1

402.39 +- 446.48

0.04 +- 0.08

No common domains found

GCF_003325375.1

731.00 +- 497.76

0.01 +- 0.00

PF00005 (2/3) ABC transporter

GCF_000721715.1

283.93 +- 79.13

0.06 +- 0.15

No common domains found

GCF_000719915.1

480.79 +- 491.75

0.02 +- 0.02

No common domains found

GCF_000515055.1

1003.43 +- 959.62

0.03 +- 0.06

GCF_000696595.1

1419.00 +- 0.00

0.01 +- 0.00

PF17914 (1/1) HopA1 effector protein family
PF01061 (1/1) ABC-2 type transporter
PF00891 (1/1) O-methyltransferase domain
PF00664 (1/1) ABC transporter transmembrane region
PF00296 (1/1) Luciferase-like monooxygenase
PF00005 (1/1) ABC transporter

GCF_000717725.1

498.08 +- 469.42

0.03 +- 0.04

GCF_002910725.2

33.91 +- 0.00

0.06 +- 0.02

GCF_000725555.1

81.67 +- 0.00

0.09 +- 0.17

TIGR02937 (1/1) RNA polymerase sigma factor, sigma-70 family
PF08281 (1/1) Sigma-70, region 4
PF04542 (1/1) Sigma-70 region 2
PF03995 (1/1) Peptidase inhibitor family I36
PF01551 (1/1) Peptidase family M23
PF01427 (1/1) D-ala-D-ala dipeptidase
PF00877 (1/1) NlpC/P60 family

GCF_000718095.1

544.76 +- 400.21

0.02 +- 0.01

No common domains found

GCF_000813365.1

258.00 +- 0.00

0.01 +- 0.00

PF04655 (1/1) Aminoglycoside/hydroxyurea antibiotic resistance kinase

GCF_001905125.1

161.98 +- 65.19

0.04 +- 0.08

No common domains found

GCF_003846195.1

258.00 +- 0.00

0.01 +- 0.00

PF10137 (1/1) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (1/1) Streptomyces sporulation and cell division protein, SsgA
PF00294 (1/1) pfkB family carbohydrate kinase

GCF_004195935.1

81.25 +- 0.00

0.02 +- 0.02

PF13515 (1/1) Fusaric acid resistance protein-like
PF08386 (1/1) TAP-like protein
PF01471 (1/1) Putative peptidoglycan binding domain
PF00561 (1/1) alpha/beta hydrolase fold

GCF_000721045.1

74.81 +- 42.70

0.06 +- 0.09

No common domains found

GCF_003994395.1

320.47 +- 296.02

0.02 +- 0.02

No common domains found

GCF_002910915.1

229.59 +- 141.11

0.06 +- 0.09

No common domains found

GCF_000717595.1

496.89 +- 322.88

0.02 +- 0.05

No common domains found

GCF_001514145.1

30.79 +- 0.00

0.10 +- 0.02

TIGR03328 (1/1) methylthioribulose-1-phosphate dehydratase
TIGR01691 (1/1) 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
PF03079 (1/1) ARD/ARD' family
PF00596 (1/1) Class II Aldolase and Adducin N-terminal domain

GCF_001514205.1

853.95 +- 746.46

0.03 +- 0.05

PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase

GCF_003353555.1

339.68 +- 115.22

0.04 +- 0.06

PF00005 (3/3) ABC transporter
PF00664 (2/3) ABC transporter transmembrane region

GCF_003352445.1

244.36 +- 204.16

0.06 +- 0.15

PF00005 (2/4) ABC transporter

GCF_900112965.1

206.64 +- 64.26

0.06 +- 0.09

PF07690 (2/2) Major Facilitator Superfamily
TIGR00976 (1/2) hydrolase CocE/NonD family protein
TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF14025 (1/2) Protein of unknown function (DUF4241)
PF13977 (1/2) BetI-type transcriptional repressor, C-terminal
PF12911 (1/2) N-terminal TM domain of oligopeptide transport permease C
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01610 (1/2) Transposase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_900215595.1

153.70 +- 0.00

0.05 +- 0.03

GCF_001905825.1

598.01 +- 600.17

0.02 +- 0.05

No common domains found

GCF_001866645.1

891.83 +- 940.89

0.02 +- 0.04

PF02784 (2/3) Pyridoxal-dependent decarboxylase, pyridoxal binding domain
PF00440 (2/3) Bacterial regulatory proteins, tetR family

GCF_000716605.1

407.92 +- 325.83

0.02 +- 0.02

No common domains found

GCF_000340845.1

530.23 +- 690.65

0.05 +- 0.06

No common domains found

GCF_001746315.1

1439.64 +- 1398.36

0.02 +- 0.04

TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF17866 (1/2) AAA lid domain
PF14867 (1/2) Lantibiotic alpha
PF13575 (1/2) Domain of unknown function (DUF4135)
PF13407 (1/2) Periplasmic binding protein domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13229 (1/2) Right handed beta helix region
PF12730 (1/2) ABC-2 family transporter protein
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF00664 (1/2) ABC transporter transmembrane region
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

GCF_002910905.1

435.18 +- 0.00

0.09 +- 0.10

TIGR01746 (1/1) thioester reductase domain
TIGR01733 (1/1) amino acid adenylation domain
TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR01525 (1/1) heavy metal translocating P-type ATPase
TIGR00747 (1/1) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF13535 (1/1) ATP-grasp domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF10862 (1/1) FcoT-like thioesterase domain
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF07993 (1/1) Male sterility protein
PF07690 (1/1) Major Facilitator Superfamily
PF05118 (1/1) Aspartyl/Asparaginyl beta-hydroxylase
PF04314 (1/1) Copper chaperone PCu(A)C
PF02668 (1/1) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/1) DJ-1/PfpI family
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00702 (1/1) haloacid dehalogenase-like hydrolase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00501 (1/1) AMP-binding enzyme
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00403 (1/1) Heavy-metal-associated domain
PF00122 (1/1) E1-E2 ATPase
PF00005 (1/1) ABC transporter

GCF_900090135.1

281.67 +- 0.00

0.02 +- 0.01

GCF_001905365.1

788.86 +- 767.24

0.02 +- 0.10

PF00082 (2/4) Subtilase family

GCF_000718245.1

135.20 +- 0.00

0.04 +- 0.03

GCF_000154905.1

780.00 +- 0.00

0.01 +- 0.00

TIGR02144 (1/1) lysine biosynthesis enzyme LysX
TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00761 (1/1) acetylglutamate kinase
PF08443 (1/1) RimK-like ATP-grasp domain
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain

GCF_001941325.1

319.58 +- 27.08

0.07 +- 0.21

GCF_001279015.1

124.03 +- 35.65

0.03 +- 0.02

No common domains found

GCF_000725545.1

276.86 +- 193.89

0.04 +- 0.06

PF07690 (2/4) Major Facilitator Superfamily

GCF_001514135.1

161.59 +- 78.28

0.05 +- 0.05

PF07690 (2/3) Major Facilitator Superfamily
PF00348 (2/3) Polyprenyl synthetase

GCF_002797835.1

410.69 +- 354.19

0.02 +- 0.03

PF07690 (4/6) Major Facilitator Superfamily

GCF_000091305.1

131.33 +- 0.00

0.08 +- 0.17

PF13407 (1/1) Periplasmic binding protein domain
PF13377 (1/1) Periplasmic binding protein-like domain
PF08530 (1/1) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF05025 (1/1) RbsD / FucU transport protein family
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF02129 (1/1) X-Pro dipeptidyl-peptidase (S15 family)
PF00430 (1/1) ATP synthase B/B' CF(0)
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00005 (1/1) ABC transporter

GCF_001751345.1

346.67 +- 0.00

0.01 +- 0.01

GCF_000383615.1

388.38 +- 219.49

0.01 +- 0.02

No common domains found

GCF_001418325.1

146.59 +- 0.00

0.07 +- 0.12

PF09084 (1/1) NMT1/THI5 like
PF04909 (1/1) Amidohydrolase
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00005 (1/1) ABC transporter

GCF_001983595.1

342.21 +- 307.79

0.06 +- 0.08

PF14518 (1/2) Iron-containing redox enzyme
PF13367 (1/2) PrsW family intramembrane metalloprotease
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF04055 (1/2) Radical SAM superfamily
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family

GCF_900111245.1

2797.24 +- 0.00

0.02 +- 0.01

GCF_001715295.1

371.43 +- 0.00

0.01 +- 0.00

GCF_002711365.1

70.91 +- 0.00

0.04 +- 0.03

PF13360 (1/1) PQQ-like domain
PF04672 (1/1) S-adenosyl methyltransferase
PF04073 (1/1) Aminoacyl-tRNA editing domain
PF00069 (1/1) Protein kinase domain

GCF_000147815.2

211.89 +- 91.85

0.05 +- 0.07

No common domains found

GCF_003268555.1

31.38 +- 0.00

0.06 +- 0.07

GCF_001279985.1

363.74 +- 289.46

0.03 +- 0.07

No common domains found

GCF_000280905.1

4680.00 +- 0.00

0.01 +- 0.01

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13601 (1/1) Winged helix DNA-binding domain
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00005 (1/1) ABC transporter

GCF_900091835.1

185.10 +- 72.34

0.03 +- 0.03

PF07690 (2/3) Major Facilitator Superfamily

GCF_003935055.1

556.62 +- 256.00

0.01 +- 0.00

PF00975 (2/3) Thioesterase domain
PF00550 (2/3) Phosphopantetheine attachment site
PF00501 (2/3) AMP-binding enzyme

GCF_000720055.1

173.48 +- 0.00

0.03 +- 0.04

GCF_000717055.1

1393.75 +- 1057.48

0.03 +- 0.04

PF13649 (2/3) Methyltransferase domain
PF02518 (2/3) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00005 (2/3) ABC transporter

GCF_900105465.1

150.39 +- 28.04

0.04 +- 0.05

GCF_001513955.1

365.93 +- 267.45

0.02 +- 0.03

PF09339 (2/4) IclR helix-turn-helix domain
PF01614 (2/4) Bacterial transcriptional regulator
PF00175 (2/4) Oxidoreductase NAD-binding domain
PF00111 (2/4) 2Fe-2S iron-sulfur cluster binding domain

GCF_001746305.1

544.76 +- 0.00

0.04 +- 0.03

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13575 (1/1) Domain of unknown function (DUF4135)
PF13407 (1/1) Periplasmic binding protein domain
PF13377 (1/1) Periplasmic binding protein-like domain
PF12730 (1/1) ABC-2 family transporter protein
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03412 (1/1) Peptidase C39 family
PF00664 (1/1) ABC transporter transmembrane region
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00005 (1/1) ABC transporter

GCF_001661615.1

107.50 +- 64.50

0.05 +- 0.09

PF04655 (1/2) Aminoglycoside/hydroxyurea antibiotic resistance kinase
PF03450 (1/2) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/2) Molybdopterin-binding domain of aldehyde dehydrogenase
PF01799 (1/2) [2Fe-2S] binding domain
PF01315 (1/2) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/2) FAD binding domain in molybdopterin dehydrogenase

GCF_000412265.2

598.25 +- 929.25

0.04 +- 0.10

No common domains found

GCF_900102245.1

205.21 +- 84.25

0.06 +- 0.18

PF00005 (2/4) ABC transporter

GCF_001550245.1

150.50 +- 107.50

0.05 +- 0.03

GCF_000720255.1

650.00 +- 0.00

0.01 +- 0.00

PF00246 (1/1) Zinc carboxypeptidase
PF00082 (1/1) Subtilase family

GCF_000158975.1

192.98 +- 31.73

0.03 +- 0.02

TIGR00126 (1/2) deoxyribose-phosphate aldolase
PF13407 (1/2) Periplasmic binding protein domain
PF07730 (1/2) Histidine kinase
PF07702 (1/2) UTRA domain
PF05025 (1/2) RbsD / FucU transport protein family
PF03621 (1/2) MbtH-like protein
PF01694 (1/2) Rhomboid family
PF00501 (1/2) AMP-binding enzyme
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_002289335.1

540.57 +- 0.00

0.07 +- 0.06

GCF_001685355.1

463.59 +- 138.41

0.03 +- 0.07

PF17914 (2/2) HopA1 effector protein family
PF01636 (2/2) Phosphotransferase enzyme family
PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01426 (1/2) glycosyltransferase, MGT family
PF13692 (1/2) Glycosyl transferases group 1
PF13601 (1/2) Winged helix DNA-binding domain
PF13469 (1/2) Sulfotransferase family
PF12698 (1/2) ABC-2 family transporter protein
PF05719 (1/2) Golgi phosphoprotein 3 (GPP34)
PF05193 (1/2) Peptidase M16 inactive domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02441 (1/2) Flavoprotein
PF00891 (1/2) O-methyltransferase domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00296 (1/2) Luciferase-like monooxygenase
PF00201 (1/2) UDP-glucoronosyl and UDP-glucosyl transferase

GCF_001704195.1

55.29 +- 0.00

0.07 +- 0.09

PF04203 (1/1) Sortase domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00583 (1/1) Acetyltransferase (GNAT) family

GCF_004196335.1

57.78 +- 0.00

0.05 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_001550315.1

247.00 +- 13.00

0.02 +- 0.01

TIGR01910 (1/2) peptidase, ArgE/DapE family
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13602 (1/2) Zinc-binding dehydrogenase
PF13564 (1/2) DoxX-like family
PF13460 (1/2) NAD(P)H-binding
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01546 (1/2) Peptidase family M20/M25/M40
PF01510 (1/2) N-acetylmuramoyl-L-alanine amidase
PF00296 (1/2) Luciferase-like monooxygenase
PF00107 (1/2) Zinc-binding dehydrogenase
PF00106 (1/2) short chain dehydrogenase

GCF_000718135.1

477.78 +- 0.00

0.02 +- 0.02

PF12833 (1/1) Helix-turn-helix domain
PF02518 (1/1) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF02311 (1/1) AraC-like ligand binding domain
PF01497 (1/1) Periplasmic binding protein
PF01032 (1/1) FecCD transport family
PF00664 (1/1) ABC transporter transmembrane region
PF00561 (1/1) alpha/beta hydrolase fold
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00072 (1/1) Response regulator receiver domain
PF00005 (1/1) ABC transporter

GCF_001509505.1

343.04 +- 193.43

0.03 +- 0.04

PF07690 (3/3) Major Facilitator Superfamily
PF04055 (2/3) Radical SAM superfamily
PF02310 (2/3) B12 binding domain
PF00326 (2/3) Prolyl oligopeptidase family

GCF_000720235.1

531.82 +- 0.00

0.03 +- 0.01

GCF_000935185.3

505.07 +- 694.41

0.03 +- 0.07

No common domains found

GCF_000707925.1

57.78 +- 0.00

0.05 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_000213055.1

516.00 +- 0.00

0.01 +- 0.00

PF13466 (1/1) STAS domain
PF08031 (1/1) Berberine and berberine like
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF03992 (1/1) Antibiotic biosynthesis monooxygenase
PF02607 (1/1) B12 binding domain
PF02310 (1/1) B12 binding domain
PF01565 (1/1) FAD binding domain

GCF_003949895.1

4797.00 +- 1833.00

0.01 +- 0.00

PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR01356 (1/2) 3-phosphoshikimate 1-carboxyvinyltransferase
TIGR01307 (1/2) phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
PF17914 (1/2) HopA1 effector protein family
PF13847 (1/2) Methyltransferase domain
PF13649 (1/2) Methyltransferase domain
PF13535 (1/2) ATP-grasp domain
PF13480 (1/2) Acetyltransferase (GNAT) domain
PF13115 (1/2) YtkA-like
PF11468 (1/2) Aromatic prenyltransferase Orf2
PF05193 (1/2) Peptidase M16 inactive domain
PF04389 (1/2) Peptidase family M28
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02441 (1/2) Flavoprotein
PF01676 (1/2) Metalloenzyme superfamily
PF01527 (1/2) Transposase
PF01061 (1/2) ABC-2 type transporter
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00403 (1/2) Heavy-metal-associated domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00275 (1/2) EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
PF00155 (1/2) Aminotransferase class I and II
PF00117 (1/2) Glutamine amidotransferase class-I

GCF_003595545.1

144.50 +- 60.79

0.04 +- 0.04

PF16353 (2/4) Domain of unknown function(DUF4981)
PF02929 (2/4) Beta galactosidase small chain
PF02837 (2/4) Glycosyl hydrolases family 2, sugar binding domain
PF02836 (2/4) Glycosyl hydrolases family 2, TIM barrel domain

GCF_003254205.1

328.70 +- 29.99

0.05 +- 0.15

No common domains found

GCF_002027195.1

32.94 +- 0.00

0.06 +- 0.07

PF14525 (1/1) AraC-binding-like domain
PF12833 (1/1) Helix-turn-helix domain
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF00107 (1/1) Zinc-binding dehydrogenase

GCF_002007125.1

236.25 +- 115.39

0.02 +- 0.03

No common domains found

GCF_001425805.1

304.58 +- 195.15

0.02 +- 0.01

No common domains found

GCF_001509485.1

240.41 +- 17.59

0.07 +- 0.15

TIGR02276 (1/2) 40-residue YVTN family beta-propeller repeat
TIGR01879 (1/2) amidase, hydantoinase/carbamoylase family
TIGR01037 (1/2) dihydroorotate dehydrogenase family protein
TIGR00857 (1/2) dihydroorotase, multifunctional complex type
PF13305 (1/2) Tetracyclin repressor-like, C-terminal domain
PF13160 (1/2) Protein of unknown function (DUF3995)
PF10418 (1/2) Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
PF10415 (1/2) Fumarase C C-terminus
PF10282 (1/2) Lactonase, 7-bladed beta-propeller
PF09339 (1/2) IclR helix-turn-helix domain
PF07931 (1/2) Chloramphenicol phosphotransferase-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF02656 (1/2) Domain of unknown function (DUF202)
PF01979 (1/2) Amidohydrolase family
PF01833 (1/2) IPT/TIG domain
PF01614 (1/2) Bacterial transcriptional regulator
PF01546 (1/2) Peptidase family M20/M25/M40
PF01180 (1/2) Dihydroorotate dehydrogenase
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00206 (1/2) Lyase

GCF_003947455.1

576.98 +- 0.00

0.01 +- 0.01

TIGR01554 (1/1) phage major capsid protein, HK97 family
TIGR01543 (1/1) phage prohead protease, HK97 family
TIGR01537 (1/1) phage portal protein, HK97 family
PF13385 (1/1) Concanavalin A-like lectin/glucanases superfamily
PF09250 (1/1) Bifunctional DNA primase/polymerase, N-terminal
PF05065 (1/1) Phage capsid family
PF04860 (1/1) Phage portal protein
PF04851 (1/1) Type III restriction enzyme, res subunit
PF04586 (1/1) Caudovirus prohead serine protease
PF01844 (1/1) HNH endonuclease
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF00271 (1/1) Helicase conserved C-terminal domain

GCF_000707965.1

44.23 +- 0.00

0.07 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_000718175.1

318.56 +- 247.95

0.03 +- 0.03

PF07690 (2/4) Major Facilitator Superfamily

GCF_001279455.1

45.22 +- 0.00

0.04 +- 0.06

PF01427 (1/1) D-ala-D-ala dipeptidase
PF00583 (1/1) Acetyltransferase (GNAT) family
PF00293 (1/1) NUDIX domain

GCF_900116325.1

84.75 +- 27.42

0.04 +- 0.02

PF17291 (1/2) N-terminal domain of M60-like peptidases
PF13402 (1/2) Peptidase M60, enhancin and enhancin-like
PF13377 (1/2) Periplasmic binding protein-like domain
PF10022 (1/2) Uncharacterized protein conserved in bacteria (DUF2264)
PF08124 (1/2) Polysaccharide lyase family 8, N terminal alpha-helical domain
PF04978 (1/2) Protein of unknown function (DUF664)
PF03795 (1/2) YCII-related domain
PF02884 (1/2) Polysaccharide lyase family 8, C-terminal beta-sandwich domain
PF02826 (1/2) D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF02278 (1/2) Polysaccharide lyase family 8, super-sandwich domain
PF00356 (1/2) Bacterial regulatory proteins, lacI family

GCF_003263925.1

798.43 +- 45.93

0.02 +- 0.01

GCF_900079415.1

35.59 +- 0.00

0.06 +- 0.05

PF13516 (1/1) Leucine Rich repeat
PF13203 (1/1) Putative metallopeptidase domain
PF09967 (1/1) VWA-like domain (DUF2201)
PF07728 (1/1) AAA domain (dynein-related subfamily)

GCF_003402595.1

2006.67 +- 0.00

0.01 +- 0.01

TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF13560 (1/1) Helix-turn-helix domain
PF04149 (1/1) Domain of unknown function (DUF397)
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (1/1) Nitroreductase family
PF00196 (1/1) Bacterial regulatory proteins, luxR family

GCF_000955965.1

434.07 +- 544.57

0.04 +- 0.06

No common domains found

GCF_003752275.1

195.00 +- 0.00

0.01 +- 0.00

PF10137 (1/1) Predicted nucleotide-binding protein containing TIR-like domain
PF04686 (1/1) Streptomyces sporulation and cell division protein, SsgA
PF00294 (1/1) pfkB family carbohydrate kinase

GCF_001417735.1

492.85 +- 334.12

0.02 +- 0.02

No common domains found

GCF_000611795.1

182.87 +- 133.35

0.04 +- 0.04

TIGR03026 (1/2) nucleotide sugar dehydrogenase
PF13471 (1/2) Transglutaminase-like superfamily
PF05544 (1/2) Proline racemase
PF03721 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
PF03720 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (1/2) Peptidase family M20/M25/M40
PF00984 (1/2) UDP-glucose/GDP-mannose dehydrogenase family, central domain
PF00733 (1/2) Asparagine synthase
PF00005 (1/2) ABC transporter

GCF_001279075.1

74.81 +- 42.70

0.06 +- 0.09

No common domains found

GCF_003147545.1

410.66 +- 348.26

0.03 +- 0.04

PF17914 (1/2) HopA1 effector protein family
PF13649 (1/2) Methyltransferase domain
PF08220 (1/2) DeoR-like helix-turn-helix domain
PF05193 (1/2) Peptidase M16 inactive domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02441 (1/2) Flavoprotein
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00455 (1/2) DeoR C terminal sensor domain
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_000717925.1

248.19 +- 24.12

0.05 +- 0.14

No common domains found

GCF_001514115.1

46.44 +- 0.00

0.06 +- 0.04

PF13796 (1/1) Putative sensor
PF07730 (1/1) Histidine kinase
PF01874 (1/1) ATP:dephospho-CoA triphosphoribosyl transferase
PF00775 (1/1) Dioxygenase

GCF_000686765.1

26.00 +- 0.00

0.08 +- 0.03

TIGR04451 (1/1) lantipeptide, SCO0268 family
TIGR03891 (1/1) thiopeptide-type bacteriocin biosynthesis domain
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF01042 (1/1) Endoribonuclease L-PSP
PF00144 (1/1) Beta-lactamase

GCF_000720915.1

247.53 +- 212.56

0.06 +- 0.07

PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter

GCF_900112355.1

390.00 +- 0.00

0.01 +- 0.01

PF13191 (1/1) AAA ATPase domain
PF13185 (1/1) GAF domain
PF07690 (1/1) Major Facilitator Superfamily
PF05147 (1/1) Lanthionine synthetase C-like protein
PF04055 (1/1) Radical SAM superfamily
PF00211 (1/1) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/1) Subtilase family
PF00069 (1/1) Protein kinase domain

GCF_000719265.1

75.53 +- 35.14

0.08 +- 0.13

PF07690 (2/2) Major Facilitator Superfamily
TIGR00556 (1/2) phosphopantetheine--protein transferase domain
TIGR00027 (1/2) methyltransferase, TIGR00027 family
PF12840 (1/2) Helix-turn-helix domain
PF12706 (1/2) Beta-lactamase superfamily domain
PF11583 (1/2) P-aminobenzoate N-oxygenase AurF
PF08386 (1/2) TAP-like protein
PF06628 (1/2) Catalase-related immune-responsive
PF06259 (1/2) Alpha/beta hydrolase
PF05977 (1/2) Transmembrane secretion effector
PF04072 (1/2) Leucine carboxyl methyltransferase
PF03403 (1/2) Platelet-activating factor acetylhydrolase, isoform II
PF01648 (1/2) 4'-phosphopantetheinyl transferase superfamily
PF01575 (1/2) MaoC like domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00199 (1/2) Catalase

GCF_003814525.1

311.06 +- 417.97

0.03 +- 0.05

PF00440 (2/4) Bacterial regulatory proteins, tetR family

GCF_002910855.1

1239.18 +- 1314.44

0.01 +- 0.01

No common domains found

GCF_003851665.1

659.92 +- 738.82

0.02 +- 0.07

No common domains found

GCF_001751255.1

390.00 +- 0.00

0.01 +- 0.00

PF07690 (1/1) Major Facilitator Superfamily
PF01557 (1/1) Fumarylacetoacetate (FAA) hydrolase family
PF01522 (1/1) Polysaccharide deacetylase
PF01042 (1/1) Endoribonuclease L-PSP

GCF_001280095.1

619.35 +- 411.04

0.02 +- 0.06

PF05977 (2/3) Transmembrane secretion effector

GCF_003550155.1

956.95 +- 577.81

0.04 +- 0.12

PF00005 (2/3) ABC transporter

GCF_001640565.1

126.26 +- 28.16

0.06 +- 0.10

No common domains found

GCF_000721955.1

1032.00 +- 516.00

0.01 +- 0.00

PF13480 (1/2) Acetyltransferase (GNAT) domain
PF10017 (1/2) Histidine-specific methyltransferase, SAM-dependent
PF07690 (1/2) Major Facilitator Superfamily
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04055 (1/2) Radical SAM superfamily
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF02310 (1/2) B12 binding domain
PF00400 (1/2) WD domain, G-beta repeat
PF00248 (1/2) Aldo/keto reductase family
PF00196 (1/2) Bacterial regulatory proteins, luxR family

GCF_900105265.1

271.29 +- 187.76

0.03 +- 0.04

No common domains found

GCF_004104485.1

117.74 +- 0.00

0.07 +- 0.12

PF13622 (1/1) Thioesterase-like superfamily
PF12146 (1/1) Serine aminopeptidase, S33
PF00872 (1/1) Transposase, Mutator family
PF00561 (1/1) alpha/beta hydrolase fold
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00487 (1/1) Fatty acid desaturase
PF00301 (1/1) Rubredoxin
PF00067 (1/1) Cytochrome P450

GCF_000716535.1

149.44 +- 26.28

0.07 +- 0.09

TIGR01409 (1/2) Tat (twin-arginine translocation) pathway signal sequence
PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16875 (1/2) Glycosyl hydrolase family 36 N-terminal domain
PF16874 (1/2) Glycosyl hydrolase family 36 C-terminal domain
PF16499 (1/2) Alpha galactosidase A
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13378 (1/2) Enolase C-terminal domain-like
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07729 (1/2) FCD domain
PF06628 (1/2) Catalase-related immune-responsive
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02065 (1/2) Melibiase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01475 (1/2) Ferric uptake regulator family
PF01081 (1/2) KDPG and KHG aldolase
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00294 (1/2) pfkB family carbohydrate kinase
PF00248 (1/2) Aldo/keto reductase family
PF00199 (1/2) Catalase

GCF_003721495.1

719.80 +- 909.03

0.04 +- 0.14

PF00005 (4/7) ABC transporter

GCF_003665095.1

1054.77 +- 0.00

0.02 +- 0.03

TIGR01188 (1/1) daunorubicin resistance ABC transporter, ATP-binding protein
PF13581 (1/1) Histidine kinase-like ATPase domain
PF13471 (1/1) Transglutaminase-like superfamily
PF12679 (1/1) ABC-2 family transporter protein
PF07994 (1/1) Myo-inositol-1-phosphate synthase
PF07730 (1/1) Histidine kinase
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF01494 (1/1) FAD binding domain
PF01061 (1/1) ABC-2 type transporter
PF00733 (1/1) Asparagine synthase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain
PF00005 (1/1) ABC transporter

GCF_000204605.1

1032.00 +- 0.00

0.01 +- 0.00

GCF_000241835.1

209.40 +- 0.00

0.08 +- 0.08

TIGR01382 (1/1) intracellular protease, PfpI family
PF13823 (1/1) Alcohol dehydrogenase GroES-associated
PF13443 (1/1) Cro/C1-type HTH DNA-binding domain
PF08240 (1/1) Alcohol dehydrogenase GroES-like domain
PF01965 (1/1) DJ-1/PfpI family
PF01266 (1/1) FAD dependent oxidoreductase
PF00589 (1/1) Phage integrase family
PF00293 (1/1) NUDIX domain
PF00248 (1/1) Aldo/keto reductase family
PF00005 (1/1) ABC transporter

GCF_000722015.1

326.39 +- 189.61

0.05 +- 0.06

PF17801 (1/2) Alpha galactosidase C-terminal beta sandwich domain
PF16499 (1/2) Alpha galactosidase A
PF14200 (1/2) Ricin-type beta-trefoil lectin domain-like
PF13472 (1/2) GDSL-like Lipase/Acylhydrolase family
PF10017 (1/2) Histidine-specific methyltransferase, SAM-dependent
PF04616 (1/2) Glycosyl hydrolases family 43
PF03781 (1/2) Sulfatase-modifying factor enzyme 1
PF03466 (1/2) LysR substrate binding domain
PF02450 (1/2) Lecithin:cholesterol acyltransferase
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00400 (1/2) WD domain, G-beta repeat
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

GCF_001278095.1

660.76 +- 973.30

0.05 +- 0.07

PF00005 (3/5) ABC transporter

GCF_002078175.1

253.04 +- 136.96

0.02 +- 0.03

TIGR03841 (1/2) probable F420-dependent oxidoreductase, Rv3093c family
PF14518 (1/2) Iron-containing redox enzyme
PF13404 (1/2) AsnC-type helix-turn-helix domain
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF04055 (1/2) Radical SAM superfamily
PF01979 (1/2) Amidohydrolase family
PF01244 (1/2) Membrane dipeptidase (Peptidase family M19)
PF01037 (1/2) Lrp/AsnC ligand binding domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00202 (1/2) Aminotransferase class-III
PF00082 (1/2) Subtilase family

GCF_003568675.1

188.57 +- 171.16

0.04 +- 0.12

No common domains found

GCF_001428885.1

1040.00 +- 390.00

0.01 +- 0.00

PF17390 (1/2) Bacterial alpha-L-rhamnosidase C-terminal domain
PF17389 (1/2) Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
PF14435 (1/2) SUKH-4 immunity protein
PF12146 (1/2) Serine aminopeptidase, S33
PF08531 (1/2) Alpha-L-rhamnosidase N-terminal domain
PF05193 (1/2) Peptidase M16 inactive domain
PF03819 (1/2) MazG nucleotide pyrophosphohydrolase domain
PF01979 (1/2) Amidohydrolase family
PF01937 (1/2) Protein of unknown function DUF89
PF01494 (1/2) FAD binding domain
PF01326 (1/2) Pyruvate phosphate dikinase, PEP/pyruvate binding domain
PF01061 (1/2) ABC-2 type transporter
PF00754 (1/2) F5/8 type C domain
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00561 (1/2) alpha/beta hydrolase fold
PF00391 (1/2) PEP-utilising enzyme, mobile domain
PF00300 (1/2) Histidine phosphatase superfamily (branch 1)
PF00005 (1/2) ABC transporter

GCF_000725575.1

207.18 +- 71.87

0.03 +- 0.05

PF13193 (2/3) AMP-binding enzyme C-terminal domain
PF00501 (2/3) AMP-binding enzyme

GCF_000716525.1

62.10 +- 9.22

0.04 +- 0.05

No common domains found

GCF_000470535.1

1677.00 +- 0.00

0.01 +- 0.00

TIGR00702 (1/1) YcaO-type kinase domain
PF13302 (1/1) Acetyltransferase (GNAT) domain
PF08007 (1/1) Cupin superfamily protein
PF07812 (1/1) TfuA-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF05193 (1/1) Peptidase M16 inactive domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (1/1) Aminoglycoside 3-N-acetyltransferase
PF00675 (1/1) Insulinase (Peptidase family M16)
PF00326 (1/1) Prolyl oligopeptidase family

GCF_002804165.1

326.87 +- 199.57

0.05 +- 0.15

PF00005 (2/3) ABC transporter

GCF_001514215.1

2798.82 +- 2661.18

0.02 +- 0.03

TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01891 (1/2) amidohydrolase
TIGR00778 (1/2) alkylhydroperoxidase AhpD family core domain
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF13646 (1/2) HEAT repeats
PF08281 (1/2) Sigma-70, region 4
PF08240 (1/2) Alcohol dehydrogenase GroES-like domain
PF07883 (1/2) Cupin domain
PF07690 (1/2) Major Facilitator Superfamily
PF04542 (1/2) Sigma-70 region 2
PF02627 (1/2) Carboxymuconolactone decarboxylase family
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF01966 (1/2) HD domain
PF01546 (1/2) Peptidase family M20/M25/M40
PF01061 (1/2) ABC-2 type transporter
PF00881 (1/2) Nitroreductase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00107 (1/2) Zinc-binding dehydrogenase
PF00067 (1/2) Cytochrome P450
PF00005 (1/2) ABC transporter

GCF_001735805.1

112.07 +- 0.00

0.04 +- 0.07

PF07730 (1/1) Histidine kinase
PF04444 (1/1) Catechol dioxygenase N terminus
PF00775 (1/1) Dioxygenase
PF00465 (1/1) Iron-containing alcohol dehydrogenase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain

GCF_000373645.1

1122.78 +- 942.78

0.01 +- 0.01

TIGR00702 (1/2) YcaO-type kinase domain
PF14518 (1/2) Iron-containing redox enzyme
PF13302 (1/2) Acetyltransferase (GNAT) domain
PF13191 (1/2) AAA ATPase domain
PF13185 (1/2) GAF domain
PF08007 (1/2) Cupin superfamily protein
PF07812 (1/2) TfuA-like protein
PF07690 (1/2) Major Facilitator Superfamily
PF05193 (1/2) Peptidase M16 inactive domain
PF04055 (1/2) Radical SAM superfamily
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02522 (1/2) Aminoglycoside 3-N-acetyltransferase
PF00675 (1/2) Insulinase (Peptidase family M16)
PF00326 (1/2) Prolyl oligopeptidase family
PF00211 (1/2) Adenylate and Guanylate cyclase catalytic domain
PF00082 (1/2) Subtilase family

GCF_000716455.1

99.00 +- 21.00

0.09 +- 0.21

TIGR00229 (1/2) PAS domain S-box protein
PF08795 (1/2) Putative papain-like cysteine peptidase (DUF1796)
PF08448 (1/2) PAS fold
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/2) UTRA domain
PF03098 (1/2) Animal haem peroxidase
PF02585 (1/2) GlcNAc-PI de-N-acetylase
PF01925 (1/2) Sulfite exporter TauE/SafE
PF01061 (1/2) ABC-2 type transporter
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00582 (1/2) Universal stress protein family
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00199 (1/2) Catalase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00005 (1/2) ABC transporter

GCF_000317595.1

115.78 +- 0.00

0.03 +- 0.05

TIGR00350 (1/1) cell envelope-related function transcriptional attenuator common domain
PF13641 (1/1) Glycosyltransferase like family 2
PF07730 (1/1) Histidine kinase
PF03816 (1/1) Cell envelope-related transcriptional attenuator domain
PF01522 (1/1) Polysaccharide deacetylase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00082 (1/1) Subtilase family
PF00072 (1/1) Response regulator receiver domain

GCF_001279545.1

516.00 +- 0.00

0.01 +- 0.00

PF10502 (1/1) Signal peptidase, peptidase S26
PF07291 (1/1) Methylamine utilisation protein MauE
PF00717 (1/1) Peptidase S24-like
PF00578 (1/1) AhpC/TSA family
PF00005 (1/1) ABC transporter

GCF_003846165.1

641.52 +- 658.99

0.02 +- 0.03

No common domains found

GCF_002794255.1

133.94 +- 39.39

0.02 +- 0.02

TIGR04362 (1/2) choice-of-anchor C domain
PF17853 (1/2) GGDEF-like domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13185 (1/2) GAF domain
PF07690 (1/2) Major Facilitator Superfamily
PF04862 (1/2) Protein of unknown function (DUF642)
PF01243 (1/2) Pyridoxamine 5'-phosphate oxidase
PF00923 (1/2) Transaldolase/Fructose-6-phosphate aldolase
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00106 (1/2) short chain dehydrogenase

GCF_001279025.1

86.67 +- 0.00

0.03 +- 0.00

PF13471 (1/1) Transglutaminase-like superfamily
PF05402 (1/1) Coenzyme PQQ synthesis protein D (PqqD)
PF00733 (1/1) Asparagine synthase

GCF_001865315.1

238.40 +- 178.40

0.09 +- 0.14

TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR01746 (1/2) thioester reductase domain
TIGR01733 (1/2) amino acid adenylation domain
TIGR01525 (1/2) heavy metal translocating P-type ATPase
TIGR00747 (1/2) 3-oxoacyl-[acyl-carrier-protein] synthase III
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF10862 (1/2) FcoT-like thioesterase domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08281 (1/2) Sigma-70, region 4
PF07993 (1/2) Male sterility protein
PF07690 (1/2) Major Facilitator Superfamily
PF05118 (1/2) Aspartyl/Asparaginyl beta-hydroxylase
PF04542 (1/2) Sigma-70 region 2
PF04314 (1/2) Copper chaperone PCu(A)C
PF04203 (1/2) Sortase domain
PF04149 (1/2) Domain of unknown function (DUF397)
PF03929 (1/2) PepSY-associated TM region
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF01965 (1/2) DJ-1/PfpI family
PF01794 (1/2) Ferric reductase like transmembrane component
PF01497 (1/2) Periplasmic binding protein
PF01032 (1/2) FecCD transport family
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00702 (1/2) haloacid dehalogenase-like hydrolase
PF00668 (1/2) Condensation domain
PF00583 (1/2) Acetyltransferase (GNAT) family
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00403 (1/2) Heavy-metal-associated domain
PF00122 (1/2) E1-E2 ATPase
PF00005 (1/2) ABC transporter

GCF_000718165.1

180.26 +- 47.24

0.06 +- 0.05

TIGR00026 (1/2) deazaflavin-dependent oxidoreductase, nitroreductase family
PF17863 (1/2) AAA lid domain
PF14310 (1/2) Fibronectin type III-like domain
PF13802 (1/2) Galactose mutarotase-like
PF13519 (1/2) von Willebrand factor type A domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13365 (1/2) Trypsin-like peptidase domain
PF07726 (1/2) ATPase family associated with various cellular activities (AAA)
PF07584 (1/2) Aerotolerance regulator N-terminal
PF04075 (1/2) F420H(2)-dependent quinone reductase
PF03422 (1/2) Carbohydrate binding module (family 6)
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF01915 (1/2) Glycosyl hydrolase family 3 C-terminal domain
PF01882 (1/2) Protein of unknown function DUF58
PF01547 (1/2) Bacterial extracellular solute-binding protein
PF01055 (1/2) Glycosyl hydrolases family 31
PF00933 (1/2) Glycosyl hydrolase family 3 N terminal domain
PF00672 (1/2) HAMP domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00072 (1/2) Response regulator receiver domain

GCF_000772045.1

66.86 +- 0.00

0.09 +- 0.01

TIGR02133 (1/1) ribose 5-phosphate isomerase
PF16896 (1/1) Phosphogluconate dehydrogenase (decarboxylating) C-term
PF07690 (1/1) Major Facilitator Superfamily
PF03807 (1/1) NADP oxidoreductase coenzyme F420-dependent
PF02734 (1/1) DAK2 domain
PF02733 (1/1) Dak1 domain
PF02502 (1/1) Ribose/Galactose Isomerase
PF01261 (1/1) Xylose isomerase-like TIM barrel
PF00121 (1/1) Triosephosphate isomerase

GCF_002813405.1

139.84 +- 26.02

0.02 +- 0.01

PF12833 (1/2) Helix-turn-helix domain
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF03358 (1/2) NADPH-dependent FMN reductase
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF01965 (1/2) DJ-1/PfpI family
PF00724 (1/2) NADH:flavin oxidoreductase / NADH oxidase family
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain

GCF_900091875.1

715.95 +- 6.45

0.01 +- 0.00

GCF_003967355.1

237.84 +- 99.46

0.05 +- 0.12

PF00155 (2/4) Aminotransferase class I and II

GCF_002082195.1

126.95 +- 16.38

0.03 +- 0.03

PF13424 (1/2) Tetratricopeptide repeat
PF07992 (1/2) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/2) UTRA domain
PF03704 (1/2) Bacterial transcriptional activator domain
PF01925 (1/2) Sulfite exporter TauE/SafE
PF00931 (1/2) NB-ARC domain
PF00664 (1/2) ABC transporter transmembrane region
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_002910985.1

468.39 +- 281.28

0.07 +- 0.09

PF00005 (2/3) ABC transporter

GCF_002155905.1

351.00 +- 0.00

0.03 +- 0.03

PF17964 (1/1) Bacterial Ig domain
PF14246 (1/1) AefR-like transcriptional repressor, C-terminal domain
PF03734 (1/1) L,D-transpeptidase catalytic domain
PF03640 (1/1) Secreted repeat of unknown function
PF00440 (1/1) Bacterial regulatory proteins, tetR family

GCF_000717375.1

28.14 +- 2.30

0.08 +- 0.10

No common domains found

GCF_000514715.1

52.75 +- 2.96

0.05 +- 0.04

TIGR02937 (1/2) RNA polymerase sigma factor, sigma-70 family
TIGR00345 (1/2) transport-energizing ATPase, TRC40/GET3/ArsA family
PF13722 (1/2) 5TM C-terminal transporter carbon starvation CstA
PF09129 (1/2) Cholesterol oxidase, substrate-binding
PF08281 (1/2) Sigma-70, region 4
PF07995 (1/2) Glucose / Sorbosone dehydrogenase
PF06283 (1/2) Trehalose utilisation
PF02554 (1/2) Carbon starvation protein CstA
PF02374 (1/2) Anion-transporting ATPase
PF01565 (1/2) FAD binding domain

GCF_001905545.1

349.48 +- 155.41

0.05 +- 0.06

No common domains found

GCF_001514045.1

520.00 +- 0.00

0.02 +- 0.00

PF11794 (1/1) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF03358 (1/1) NADPH-dependent FMN reductase
PF03241 (1/1) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF01321 (1/1) Creatinase/Prolidase N-terminal domain
PF00557 (1/1) Metallopeptidase family M24
PF00291 (1/1) Pyridoxal-phosphate dependent enzyme

GCF_003963535.1

283.41 +- 189.96

0.02 +- 0.03

PF00296 (2/3) Luciferase-like monooxygenase

GCF_900187925.1

297.92 +- 135.42

0.04 +- 0.10

PF18029 (1/2) Glyoxalase-like domain
PF11758 (1/2) Aureocin-like type II bacteriocin
PF07690 (1/2) Major Facilitator Superfamily
PF03372 (1/2) Endonuclease/Exonuclease/phosphatase family
PF02518 (1/2) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00768 (1/2) D-alanyl-D-alanine carboxypeptidase
PF00672 (1/2) HAMP domain
PF00512 (1/2) His Kinase A (phospho-acceptor) domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00072 (1/2) Response regulator receiver domain

GCF_003386135.1

412.94 +- 0.00

0.01 +- 0.01

GCF_900095575.1

153.78 +- 136.72

0.06 +- 0.09

No common domains found

GCF_000148465.1

682.50 +- 0.00

0.01 +- 0.00

TIGR01509 (1/1) HAD hydrolase, family IA, variant 3
PF18181 (1/1) SMODS and SLOG-associating 2TM effector domain 1
PF16864 (1/1) Dimerisation domain
PF14015 (1/1) Protein of unknown function (DUF4231)
PF13692 (1/1) Glycosyl transferases group 1
PF13676 (1/1) TIR domain
PF13561 (1/1) Enoyl-(Acyl carrier protein) reductase
PF13419 (1/1) Haloacid dehalogenase-like hydrolase
PF13292 (1/1) 1-deoxy-D-xylulose-5-phosphate synthase
PF12464 (1/1) Maltose acetyltransferase
PF11941 (1/1) Domain of unknown function (DUF3459)
PF07728 (1/1) AAA domain (dynein-related subfamily)
PF05729 (1/1) NACHT domain
PF01636 (1/1) Phosphotransferase enzyme family
PF00891 (1/1) O-methyltransferase domain
PF00202 (1/1) Aminotransferase class-III
PF00132 (1/1) Bacterial transferase hexapeptide (six repeats)

GCF_000495635.1

127.02 +- 0.00

0.06 +- 0.16

TIGR02412 (1/1) aminopeptidase N
TIGR01686 (1/1) FkbH domain
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF13434 (1/1) L-lysine 6-monooxygenase (NADPH-requiring)
PF11838 (1/1) ERAP1-like C-terminal domain
PF09334 (1/1) tRNA synthetases class I (M)
PF08545 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/1) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF07883 (1/1) Cupin domain
PF07690 (1/1) Major Facilitator Superfamily
PF02274 (1/1) Amidinotransferase
PF02195 (1/1) ParB-like nuclease domain
PF01433 (1/1) Peptidase family M1 domain
PF01266 (1/1) FAD dependent oxidoreductase
PF00999 (1/1) Sodium/hydrogen exchanger family
PF00550 (1/1) Phosphopantetheine attachment site
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle

GCF_002939385.1

90.00 +- 0.00

0.03 +- 0.04

PF02817 (1/1) e3 binding domain
PF02780 (1/1) Transketolase, C-terminal domain
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF00676 (1/1) Dehydrogenase E1 component
PF00557 (1/1) Metallopeptidase family M24
PF00364 (1/1) Biotin-requiring enzyme
PF00198 (1/1) 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

GCF_003626645.1

785.74 +- 636.85

0.01 +- 0.01

PF00067 (2/4) Cytochrome P450

GCF_002754615.1

1824.43 +- 276.43

0.01 +- 0.00

GCF_001406115.1

2282.22 +- 2553.69

0.01 +- 0.01

No common domains found

GCF_003846175.1

209.39 +- 101.23

0.03 +- 0.05

No common domains found

GCF_000411315.1

125.85 +- 66.96

0.04 +- 0.14

No common domains found

GCF_000721105.1

593.03 +- 478.29

0.04 +- 0.14

PF13561 (3/6) Enoyl-(Acyl carrier protein) reductase

GCF_000818175.1

505.38 +- 619.18

0.03 +- 0.11

No common domains found

GCF_000719785.1

164.68 +- 0.00

0.06 +- 0.05

PF05147 (1/1) Lanthionine synthetase C-like protein
PF01810 (1/1) LysE type translocator
PF00877 (1/1) NlpC/P60 family
PF00664 (1/1) ABC transporter transmembrane region
PF00069 (1/1) Protein kinase domain
PF00005 (1/1) ABC transporter

GCF_001008345.1

1118.15 +- 743.00

0.02 +- 0.02

No common domains found

GCF_900091845.1

1949.71 +- 2474.96

0.02 +- 0.04

PF00005 (3/4) ABC transporter

GCF_900091865.1

206.72 +- 39.19

0.07 +- 0.15

PF00005 (3/3) ABC transporter
PF13561 (2/3) Enoyl-(Acyl carrier protein) reductase

GCF_001905645.1

87.41 +- 0.00

0.05 +- 0.14

TIGR01760 (1/1) phage tail tape measure protein, TP901 family, core region
TIGR01409 (1/1) Tat (twin-arginine translocation) pathway signal sequence
PF16945 (1/1) Putative lactococcus lactis phage r1t holin
PF13830 (1/1) Domain of unknown function (DUF4192)
PF10145 (1/1) Phage-related minor tail protein
PF05709 (1/1) Phage tail protein
PF04883 (1/1) Bacteriophage HK97-gp10, putative tail-component
PF03837 (1/1) RecT family
PF02384 (1/1) N-6 DNA Methylase
PF01510 (1/1) N-acetylmuramoyl-L-alanine amidase
PF00216 (1/1) Bacterial DNA-binding protein
PF00145 (1/1) C-5 cytosine-specific DNA methylase

GCF_000715745.1

444.11 +- 290.54

0.04 +- 0.02

PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF16197 (1/2) Ketoacyl-synthetase C-terminal extension
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12679 (1/2) ABC-2 family transporter protein
PF12146 (1/2) Serine aminopeptidase, S33
PF08545 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (1/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF07690 (1/2) Major Facilitator Superfamily
PF04909 (1/2) Amidohydrolase
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01144 (1/2) Coenzyme A transferase
PF00698 (1/2) Acyl transferase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00296 (1/2) Luciferase-like monooxygenase
PF00202 (1/2) Aminotransferase class-III
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter

GCF_000819545.1

1214.93 +- 1193.07

0.03 +- 0.05

TIGR01910 (1/2) peptidase, ArgE/DapE family
PF17853 (1/2) GGDEF-like domain
PF13669 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13516 (1/2) Leucine Rich repeat
PF13203 (1/2) Putative metallopeptidase domain
PF09967 (1/2) VWA-like domain (DUF2201)
PF09084 (1/2) NMT1/THI5 like
PF08450 (1/2) SMP-30/Gluconolactonase/LRE-like region
PF07905 (1/2) Purine catabolism regulatory protein-like family
PF07728 (1/2) AAA domain (dynein-related subfamily)
PF06094 (1/2) Gamma-glutamyl cyclotransferase, AIG2-like
PF04909 (1/2) Amidohydrolase
PF02780 (1/2) Transketolase, C-terminal domain
PF02779 (1/2) Transketolase, pyrimidine binding domain
PF01979 (1/2) Amidohydrolase family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01019 (1/2) Gamma-glutamyltranspeptidase
PF00676 (1/2) Dehydrogenase E1 component
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00005 (1/2) ABC transporter

GCF_002966105.1

153.06 +- 9.30

0.06 +- 0.09

PF13419 (2/3) Haloacid dehalogenase-like hydrolase

GCF_000720295.1

280.36 +- 169.38

0.02 +- 0.04

No common domains found

GCF_003635085.1

445.11 +- 328.89

0.07 +- 0.19

TIGR04085 (1/2) radical SAM additional 4Fe4S-binding SPASM domain
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR02009 (1/2) beta-phosphoglucomutase family hydrolase
TIGR00350 (1/2) cell envelope-related function transcriptional attenuator common domain
PF18029 (1/2) Glyoxalase-like domain
PF17866 (1/2) AAA lid domain
PF14436 (1/2) Bacterial EndoU nuclease
PF13560 (1/2) Helix-turn-helix domain
PF13419 (1/2) Haloacid dehalogenase-like hydrolase
PF13399 (1/2) LytR cell envelope-related transcriptional attenuator
PF13229 (1/2) Right handed beta helix region
PF13186 (1/2) Iron-sulfur cluster-binding domain
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07883 (1/2) Cupin domain
PF05402 (1/2) Coenzyme PQQ synthesis protein D (PqqD)
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04055 (1/2) Radical SAM superfamily
PF03816 (1/2) Cell envelope-related transcriptional attenuator domain
PF03636 (1/2) Glycosyl hydrolase family 65, N-terminal domain
PF03633 (1/2) Glycosyl hydrolase family 65, C-terminal domain
PF03632 (1/2) Glycosyl hydrolase family 65 central catalytic domain
PF02776 (1/2) Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PF02775 (1/2) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01061 (1/2) ABC-2 type transporter
PF00717 (1/2) Peptidase S24-like
PF00205 (1/2) Thiamine pyrophosphate enzyme, central domain
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

GCF_003947555.1

516.00 +- 0.00

0.01 +- 0.00

TIGR00702 (1/1) YcaO-type kinase domain
PF18029 (1/1) Glyoxalase-like domain
PF13489 (1/1) Methyltransferase domain
PF13231 (1/1) Dolichyl-phosphate-mannose-protein mannosyltransferase
PF07812 (1/1) TfuA-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding

GCF_002910935.1

320.87 +- 284.91

0.04 +- 0.07

PF05147 (2/3) Lanthionine synthetase C-like protein
PF00664 (2/3) ABC transporter transmembrane region
PF00005 (2/3) ABC transporter

GCF_003945545.1

438.75 +- 211.25

0.01 +- 0.01

TIGR00348 (1/2) type I site-specific deoxyribonuclease, HsdR family
PF18766 (1/2) SWI2/SNF2 ATPase
PF17820 (1/2) PDZ domain
PF14659 (1/2) Phage integrase, N-terminal SAM-like domain
PF13661 (1/2) 2OG-Fe(II) oxygenase superfamily
PF13649 (1/2) Methyltransferase domain
PF13304 (1/2) AAA domain, putative AbiEii toxin, Type IV TA system
PF12161 (1/2) HsdM N-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF05729 (1/2) NACHT domain
PF05721 (1/2) Phytanoyl-CoA dioxygenase (PhyH)
PF04339 (1/2) Peptidogalycan biosysnthesis/recognition
PF04313 (1/2) Type I restriction enzyme R protein N terminus (HSDR_N)
PF04055 (1/2) Radical SAM superfamily
PF02384 (1/2) N-6 DNA Methylase
PF01863 (1/2) Protein of unknown function DUF45
PF01420 (1/2) Type I restriction modification DNA specificity domain
PF00589 (1/2) Phage integrase family

GCF_001418465.1

1105.00 +- 325.00

0.01 +- 0.00

TIGR03882 (2/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/2) SagB-type dehydrogenase domain
PF02624 (2/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02517 (2/2) CPBP intramembrane metalloprotease
PF00881 (2/2) Nitroreductase family
PF00296 (2/2) Luciferase-like monooxygenase
PF04055 (1/2) Radical SAM superfamily
PF02909 (1/2) Tetracyclin repressor-like, C-terminal domain
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00440 (1/2) Bacterial regulatory proteins, tetR family

GCF_001418125.1

67.14 +- 7.14

0.04 +- 0.05

GCF_002551145.1

1322.72 +- 1257.28

0.04 +- 0.07

PF00664 (2/2) ABC transporter transmembrane region
PF00005 (2/2) ABC transporter
TIGR03897 (1/2) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/2) Lantibiotic alpha
PF14534 (1/2) Domain of unknown function (DUF4440)
PF13575 (1/2) Domain of unknown function (DUF4135)
PF12730 (1/2) ABC-2 family transporter protein
PF12697 (1/2) Alpha/beta hydrolase family
PF08002 (1/2) Protein of unknown function (DUF1697)
PF07730 (1/2) Histidine kinase
PF05922 (1/2) Peptidase inhibitor I9
PF05147 (1/2) Lanthionine synthetase C-like protein
PF03412 (1/2) Peptidase C39 family
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
PF00072 (1/2) Response regulator receiver domain

GCF_000725805.1

769.06 +- 838.09

0.05 +- 0.18

PF07690 (2/3) Major Facilitator Superfamily

GCF_900460115.1

41.61 +- 0.00

0.10 +- 0.09

PF13370 (1/1) 4Fe-4S single cluster domain of Ferredoxin I
PF07690 (1/1) Major Facilitator Superfamily
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00067 (1/1) Cytochrome P450

GCF_000424785.1

650.00 +- 0.00

0.01 +- 0.00

PF16113 (1/1) Enoyl-CoA hydratase/isomerase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09339 (1/1) IclR helix-turn-helix domain
PF02515 (1/1) CoA-transferase family III
PF01614 (1/1) Bacterial transcriptional regulator
PF01144 (1/1) Coenzyme A transferase
PF00501 (1/1) AMP-binding enzyme

GCF_004104505.1

240.80 +- 0.00

0.03 +- 0.04

TIGR03083 (1/1) uncharacterized Actinobacterial protein TIGR03083
PF17964 (1/1) Bacterial Ig domain
PF11716 (1/1) Mycothiol maleylpyruvate isomerase N-terminal domain
PF07702 (1/1) UTRA domain
PF07398 (1/1) MDMPI C-terminal domain
PF03734 (1/1) L,D-transpeptidase catalytic domain
PF01381 (1/1) Helix-turn-helix
PF00931 (1/1) NB-ARC domain
PF00392 (1/1) Bacterial regulatory proteins, gntR family

GCF_000720995.1

803.12 +- 586.07

0.01 +- 0.02

PF00891 (2/4) O-methyltransferase domain

GCF_002277855.1

264.83 +- 196.42

0.05 +- 0.07

TIGR03812 (1/2) tyrosine decarboxylase MnfA
PF17755 (1/2) UvrA DNA-binding domain
PF16861 (1/2) Carbamoyltransferase C-terminus
PF16169 (1/2) Domain of unknown function (DUF4872)
PF14399 (1/2) Butirosin biosynthesis protein H, N-terminal
PF13847 (1/2) Methyltransferase domain
PF13671 (1/2) AAA domain
PF13649 (1/2) Methyltransferase domain
PF13377 (1/2) Periplasmic binding protein-like domain
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF12833 (1/2) Helix-turn-helix domain
PF11794 (1/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (1/2) DNA alkylation repair enzyme
PF08241 (1/2) Methyltransferase domain
PF07690 (1/2) Major Facilitator Superfamily
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (1/2) Radical SAM superfamily
PF03745 (1/2) Domain of unknown function (DUF309)
PF03241 (1/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (1/2) Carbamoyltransferase N-terminus
PF02310 (1/2) B12 binding domain
PF02195 (1/2) ParB-like nuclease domain
PF01613 (1/2) Flavin reductase like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01497 (1/2) Periplasmic binding protein
PF01427 (1/2) D-ala-D-ala dipeptidase
PF01061 (1/2) ABC-2 type transporter
PF01032 (1/2) FecCD transport family
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00501 (1/2) AMP-binding enzyme
PF00384 (1/2) Molybdopterin oxidoreductase
PF00356 (1/2) Bacterial regulatory proteins, lacI family
PF00293 (1/2) NUDIX domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00005 (1/2) ABC transporter

GCF_001279065.1

61.58 +- 0.00

0.05 +- 0.03

PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/1) UTRA domain
PF01925 (1/1) Sulfite exporter TauE/SafE
PF00392 (1/1) Bacterial regulatory proteins, gntR family

GCF_000717065.1

541.80 +- 284.97

0.01 +- 0.01

PF00501 (2/3) AMP-binding enzyme

GCF_002156095.1

910.00 +- 650.00

0.01 +- 0.00

TIGR01840 (1/2) esterase, PHB depolymerase family
PF13365 (1/2) Trypsin-like peptidase domain
PF13191 (1/2) AAA ATPase domain
PF10503 (1/2) Esterase PHB depolymerase
PF08007 (1/2) Cupin superfamily protein
PF03412 (1/2) Peptidase C39 family
PF00668 (1/2) Condensation domain
PF00664 (1/2) ABC transporter transmembrane region
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00400 (1/2) WD domain, G-beta repeat
PF00005 (1/2) ABC transporter

GCF_002028385.1

387.00 +- 0.00

0.01 +- 0.00

GCF_002094995.1

1137.27 +- 1559.20

0.02 +- 0.04

TIGR01525 (2/3) heavy metal translocating P-type ATPase
PF00702 (2/3) haloacid dehalogenase-like hydrolase
PF00403 (2/3) Heavy-metal-associated domain
PF00122 (2/3) E1-E2 ATPase

GCF_000829715.2

406.94 +- 179.37

0.02 +- 0.04

PF07690 (2/4) Major Facilitator Superfamily
PF00069 (2/4) Protein kinase domain

GCF_002551175.1

585.00 +- 65.00

0.01 +- 0.01

PF18029 (1/2) Glyoxalase-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF05147 (1/2) Lanthionine synthetase C-like protein
PF04672 (1/2) S-adenosyl methyltransferase
PF00903 (1/2) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00664 (1/2) ABC transporter transmembrane region
PF00326 (1/2) Prolyl oligopeptidase family
PF00069 (1/2) Protein kinase domain
PF00005 (1/2) ABC transporter

GCF_001514195.1

43.00 +- 0.00

0.07 +- 0.09

PF13649 (1/1) Methyltransferase domain
PF07730 (1/1) Histidine kinase
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00072 (1/1) Response regulator receiver domain

GCF_001984445.1

142.38 +- 74.91

0.06 +- 0.08

PF00005 (3/4) ABC transporter
PF00664 (2/4) ABC transporter transmembrane region

GCF_003268675.1

199.06 +- 117.79

0.07 +- 0.04

PF08545 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08541 (2/2) 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
PF02801 (2/2) Beta-ketoacyl synthase, C-terminal domain
PF00109 (2/2) Beta-ketoacyl synthase, N-terminal domain
TIGR00976 (1/2) hydrolase CocE/NonD family protein
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF12840 (1/2) Helix-turn-helix domain
PF12697 (1/2) Alpha/beta hydrolase family
PF12679 (1/2) ABC-2 family transporter protein
PF10400 (1/2) Virulence activator alpha C-term
PF08530 (1/2) X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF04909 (1/2) Amidohydrolase
PF03551 (1/2) Transcriptional regulator PadR-like family
PF02129 (1/2) X-Pro dipeptidyl-peptidase (S15 family)
PF01756 (1/2) Acyl-CoA oxidase
PF01144 (1/2) Coenzyme A transferase
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00378 (1/2) Enoyl-CoA hydratase/isomerase
PF00294 (1/2) pfkB family carbohydrate kinase
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00005 (1/2) ABC transporter

GCF_003112535.1

47.39 +- 0.00

0.06 +- 0.05

PF07690 (1/1) Major Facilitator Superfamily
PF02031 (1/1) Streptomyces extracellular neutral proteinase (M7) family
PF00069 (1/1) Protein kinase domain

GCF_900104935.1

181.01 +- 0.00

0.06 +- 0.03

GCF_003584825.1

31.21 +- 0.00

0.10 +- 0.06

PF13478 (1/1) XdhC Rossmann domain
PF09339 (1/1) IclR helix-turn-helix domain
PF03450 (1/1) CO dehydrogenase flavoprotein C-terminal domain
PF02738 (1/1) Molybdopterin-binding domain of aldehyde dehydrogenase
PF02625 (1/1) XdhC and CoxI family
PF01799 (1/1) [2Fe-2S] binding domain
PF01315 (1/1) Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF00941 (1/1) FAD binding domain in molybdopterin dehydrogenase
PF00111 (1/1) 2Fe-2S iron-sulfur cluster binding domain

GCF_000718895.1

42.62 +- 5.76

0.06 +- 0.00

GCF_000342125.1

151.67 +- 0.00

0.03 +- 0.04

PF14016 (1/1) Protein of unknown function (DUF4232)
PF07690 (1/1) Major Facilitator Superfamily
PF07301 (1/1) Protein of unknown function (DUF1453)
PF07228 (1/1) Stage II sporulation protein E (SpoIIE)
PF01047 (1/1) MarR family

GCF_000429085.1

893.08 +- 0.00

0.01 +- 0.01

PF11953 (1/1) Domain of unknown function (DUF3470)
PF02771 (1/1) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/1) Acyl-CoA dehydrogenase, middle domain
PF02597 (1/1) ThiS family
PF00501 (1/1) AMP-binding enzyme
PF00441 (1/1) Acyl-CoA dehydrogenase, C-terminal domain
PF00037 (1/1) 4Fe-4S binding domain

GCF_002940705.1

560.44 +- 614.96

0.03 +- 0.06

No common domains found

GCF_000359525.1

258.00 +- 0.00

0.01 +- 0.00

PF01757 (1/1) Acyltransferase family
PF00248 (1/1) Aldo/keto reductase family

GCF_000717715.1

442.64 +- 286.14

0.02 +- 0.04

TIGR03882 (2/4) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (2/4) SagB-type dehydrogenase domain
TIGR03604 (2/4) thiazole/oxazole-forming peptide maturase, SagD family component
PF03412 (2/4) Peptidase C39 family
PF02624 (2/4) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF00881 (2/4) Nitroreductase family
PF00664 (2/4) ABC transporter transmembrane region
PF00067 (2/4) Cytochrome P450
PF00005 (2/4) ABC transporter

GCF_003403055.1

220.90 +- 280.81

0.05 +- 0.08

No common domains found

GCF_003287935.1

350.67 +- 183.60

0.04 +- 0.17

PF07690 (2/3) Major Facilitator Superfamily

GCF_900119365.1

254.47 +- 106.43

0.03 +- 0.04

No common domains found

GCF_000719655.1

169.48 +- 124.61

0.08 +- 0.17

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR03860 (1/2) FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family
TIGR01733 (1/2) amino acid adenylation domain
TIGR01720 (1/2) non-ribosomal peptide synthase domain TIGR01720
TIGR01188 (1/2) daunorubicin resistance ABC transporter, ATP-binding protein
PF13796 (1/2) Putative sensor
PF13578 (1/2) Methyltransferase domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08659 (1/2) KR domain
PF07730 (1/2) Histidine kinase
PF07690 (1/2) Major Facilitator Superfamily
PF06259 (1/2) Alpha/beta hydrolase
PF03621 (1/2) MbtH-like protein
PF02687 (1/2) FtsX-like permease family
PF02668 (1/2) Taurine catabolism dioxygenase TauD, TfdA family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01757 (1/2) Acyltransferase family
PF01061 (1/2) ABC-2 type transporter
PF00975 (1/2) Thioesterase domain
PF00668 (1/2) Condensation domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00296 (1/2) Luciferase-like monooxygenase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00106 (1/2) short chain dehydrogenase
PF00072 (1/2) Response regulator receiver domain
PF00005 (1/2) ABC transporter

GCF_000719285.1

157.98 +- 7.98

0.04 +- 0.05

PF13416 (1/2) Bacterial extracellular solute-binding protein
PF05426 (1/2) Alginate lyase
PF05345 (1/2) Putative Ig domain
PF04151 (1/2) Bacterial pre-peptidase C-terminal domain
PF04073 (1/2) Aminoacyl-tRNA editing domain
PF01116 (1/2) Fructose-bisphosphate aldolase class-II
PF00892 (1/2) EamA-like transporter family
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00464 (1/2) Serine hydroxymethyltransferase
PF00135 (1/2) Carboxylesterase family
PF00082 (1/2) Subtilase family

GCF_003143935.1

1789.88 +- 2544.43

0.01 +- 0.00

No common domains found

GCF_000725785.1

316.97 +- 269.70

0.03 +- 0.03

TIGR01415 (1/2) pyridoxal-phosphate dependent TrpB-like enzyme
PF18603 (1/2) L-amino acid ligase C-terminal domain 2
PF18130 (1/2) ATP-grasp N-terminal domain
PF13535 (1/2) ATP-grasp domain
PF13193 (1/2) AMP-binding enzyme C-terminal domain
PF08223 (1/2) PaaX-like protein C-terminal domain
PF07848 (1/2) PaaX-like protein
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF06368 (1/2) Methylaspartate mutase E chain (MutE)
PF06339 (1/2) Ectoine synthase
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02310 (1/2) B12 binding domain
PF01841 (1/2) Transglutaminase-like superfamily
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00550 (1/2) Phosphopantetheine attachment site
PF00501 (1/2) AMP-binding enzyme
PF00441 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme

GCF_003054555.1

273.00 +- 117.00

0.01 +- 0.01

PF09851 (1/2) Short C-terminal domain
PF04972 (1/2) BON domain
PF01061 (1/2) ABC-2 type transporter
PF00582 (1/2) Universal stress protein family
PF00571 (1/2) CBS domain
PF00498 (1/2) FHA domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00082 (1/2) Subtilase family
PF00005 (1/2) ABC transporter

GCF_001704635.1

688.00 +- 0.00

0.01 +- 0.01

TIGR03897 (1/1) type 2 lantibiotic biosynthesis protein LanM
PF14867 (1/1) Lantibiotic alpha
PF13575 (1/1) Domain of unknown function (DUF4135)
PF05147 (1/1) Lanthionine synthetase C-like protein
PF03704 (1/1) Bacterial transcriptional activator domain
PF03412 (1/1) Peptidase C39 family
PF03372 (1/1) Endonuclease/Exonuclease/phosphatase family
PF00664 (1/1) ABC transporter transmembrane region
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter

GCF_000718235.1

228.18 +- 23.37

0.04 +- 0.06

TIGR03930 (1/2) WXG100 family type VII secretion target
TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03882 (1/2) bacteriocin biosynthesis cyclodehydratase domain
TIGR03605 (1/2) SagB-type dehydrogenase domain
TIGR03604 (1/2) thiazole/oxazole-forming peptide maturase, SagD family component
PF15644 (1/2) Papain fold toxin 1, glutamine deamidase
PF14028 (1/2) Lantibiotic biosynthesis dehydratase C-term
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF07179 (1/2) SseB protein N-terminal domain
PF06013 (1/2) Proteins of 100 residues with WXG
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04738 (1/2) Lantibiotic dehydratase, N terminus
PF03704 (1/2) Bacterial transcriptional activator domain
PF02624 (1/2) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01061 (1/2) ABC-2 type transporter
PF00931 (1/2) NB-ARC domain
PF00881 (1/2) Nitroreductase family
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00486 (1/2) Transcriptional regulatory protein, C terminal
PF00005 (1/2) ABC transporter

GCF_002742045.1

483.75 +- 0.00

0.01 +- 0.01

PF02225 (1/1) PA domain
PF01978 (1/1) Sugar-specific transcriptional regulator TrmB
PF00196 (1/1) Bacterial regulatory proteins, luxR family
PF00082 (1/1) Subtilase family

GCF_900290235.1

189.09 +- 0.00

0.04 +- 0.01

TIGR01902 (1/1) N-acetyl-ornithine/N-acetyl-lysine deacetylase
TIGR01850 (1/1) N-acetyl-gamma-glutamyl-phosphate reductase
TIGR00768 (1/1) alpha-L-glutamate ligase, RimK family
PF18603 (1/1) L-amino acid ligase C-terminal domain 2
PF18130 (1/1) ATP-grasp N-terminal domain
PF13535 (1/1) ATP-grasp domain
PF08443 (1/1) RimK-like ATP-grasp domain
PF07690 (1/1) Major Facilitator Superfamily
PF02779 (1/1) Transketolase, pyrimidine binding domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01118 (1/1) Semialdehyde dehydrogenase, NAD binding domain
PF01041 (1/1) DegT/DnrJ/EryC1/StrS aminotransferase family
PF00696 (1/1) Amino acid kinase family
PF00456 (1/1) Transketolase, thiamine diphosphate binding domain

GCF_003363195.1

187.63 +- 121.22

0.03 +- 0.06

No common domains found

GCF_000720215.1

547.34 +- 387.13

0.03 +- 0.02

PF00005 (2/2) ABC transporter
TIGR03812 (1/2) tyrosine decarboxylase MnfA
PF17755 (1/2) UvrA DNA-binding domain
PF16861 (1/2) Carbamoyltransferase C-terminus
PF16169 (1/2) Domain of unknown function (DUF4872)
PF14399 (1/2) Butirosin biosynthesis protein H, N-terminal
PF13416 (1/2) Bacterial extracellular solute-binding protein
PF13370 (1/2) 4Fe-4S single cluster domain of Ferredoxin I
PF11794 (1/2) 4-hydroxyphenylacetate 3-hydroxylase N terminal
PF08713 (1/2) DNA alkylation repair enzyme
PF08402 (1/2) TOBE domain
PF08386 (1/2) TAP-like protein
PF08241 (1/2) Methyltransferase domain
PF04879 (1/2) Molybdopterin oxidoreductase Fe4S4 domain
PF04055 (1/2) Radical SAM superfamily
PF03241 (1/2) 4-hydroxyphenylacetate 3-hydroxylase C terminal
PF02543 (1/2) Carbamoyltransferase N-terminus
PF02310 (1/2) B12 binding domain
PF02195 (1/2) ParB-like nuclease domain
PF01613 (1/2) Flavin reductase like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01266 (1/2) FAD dependent oxidoreductase
PF01061 (1/2) ABC-2 type transporter
PF00805 (1/2) Pentapeptide repeats (8 copies)
PF00795 (1/2) Carbon-nitrogen hydrolase
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00501 (1/2) AMP-binding enzyme
PF00384 (1/2) Molybdopterin oxidoreductase
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00282 (1/2) Pyridoxal-dependent decarboxylase conserved domain
PF00171 (1/2) Aldehyde dehydrogenase family

GCF_000316095.1

71.09 +- 0.00

0.07 +- 0.11

GCF_004028635.1

707.69 +- 1054.35

0.02 +- 0.03

No common domains found

GCF_003950035.1

427.13 +- 281.52

0.02 +- 0.03

No common domains found

GCF_003752205.1

508.03 +- 321.03

0.02 +- 0.05

PF07690 (3/4) Major Facilitator Superfamily
PF00291 (2/4) Pyridoxal-phosphate dependent enzyme

GCF_003096915.1

902.09 +- 1203.88

0.05 +- 0.17

TIGR01733 (2/4) amino acid adenylation domain
PF13561 (2/4) Enoyl-(Acyl carrier protein) reductase
PF13193 (2/4) AMP-binding enzyme C-terminal domain
PF00975 (2/4) Thioesterase domain
PF00903 (2/4) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (2/4) Condensation domain
PF00550 (2/4) Phosphopantetheine attachment site
PF00501 (2/4) AMP-binding enzyme
PF00296 (2/4) Luciferase-like monooxygenase

GCF_000340335.1

3120.00 +- 0.00

0.01 +- 0.00

GCF_003501885.1

63.00 +- 0.00

0.05 +- 0.02

GCF_001187435.1

167.14 +- 0.00

0.04 +- 0.08

TIGR01733 (1/1) amino acid adenylation domain
PF17645 (1/1) Arylmalonate decarboxylase
PF11695 (1/1) Domain of unknown function (DUF3291)
PF08962 (1/1) Domain of unknown function (DUF1876)
PF08386 (1/1) TAP-like protein
PF07690 (1/1) Major Facilitator Superfamily
PF01361 (1/1) Tautomerase enzyme
PF00975 (1/1) Thioesterase domain
PF00561 (1/1) alpha/beta hydrolase fold
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00144 (1/1) Beta-lactamase

GCF_003352805.1

103.20 +- 0.00

0.02 +- 0.01

TIGR03296 (1/1) M6 family metalloprotease domain
PF04672 (1/1) S-adenosyl methyltransferase

GCF_003391135.1

360.33 +- 142.21

0.03 +- 0.09

No common domains found

GCF_001767375.1

270.40 +- 0.00

0.09 +- 0.26

GCF_000364805.1

404.44 +- 0.00

0.02 +- 0.01

GCF_000514055.1

109.97 +- 12.47

0.06 +- 0.04

GCF_000816485.1

650.00 +- 0.00

0.01 +- 0.00

GCF_002128465.1

1373.12 +- 0.00

0.01 +- 0.00

TIGR03696 (1/1) RHS repeat-associated core domain
TIGR03494 (1/1) salicylate synthase
TIGR02185 (1/1) putative ECF transporter S component, Trep_Strep family
TIGR01733 (1/1) amino acid adenylation domain
TIGR01643 (1/1) YD repeat (two copies)
TIGR01536 (1/1) asparagine synthase (glutamine-hydrolyzing)
TIGR01443 (1/1) intein C-terminal splicing region
PF13537 (1/1) Glutamine amidotransferase domain
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09605 (1/1) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (1/1) Pretoxin HINT domain
PF05593 (1/1) RHS Repeat
PF03704 (1/1) Bacterial transcriptional activator domain
PF02361 (1/1) Cobalt transport protein
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00733 (1/1) Asparagine synthase
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00425 (1/1) chorismate binding enzyme
PF00005 (1/1) ABC transporter

GCF_900091885.1

119.08 +- 0.00

0.03 +- 0.03

PF03067 (1/1) Lytic polysaccharide mono-oxygenase, cellulose-degrading
PF01145 (1/1) SPFH domain / Band 7 family
PF00877 (1/1) NlpC/P60 family

GCF_000725565.1

50.48 +- 0.00

0.06 +- 0.04

PF07992 (1/1) Pyridine nucleotide-disulphide oxidoreductase
PF07702 (1/1) UTRA domain
PF01925 (1/1) Sulfite exporter TauE/SafE
PF00392 (1/1) Bacterial regulatory proteins, gntR family

GCF_000725725.1

519.87 +- 494.82

0.05 +- 0.19

PF07690 (2/3) Major Facilitator Superfamily

GCF_001005405.1

286.67 +- 0.00

0.03 +- 0.00

PF13407 (1/1) Periplasmic binding protein domain
PF13377 (1/1) Periplasmic binding protein-like domain
PF05025 (1/1) RbsD / FucU transport protein family
PF02653 (1/1) Branched-chain amino acid transport system / permease component
PF00356 (1/1) Bacterial regulatory proteins, lacI family
PF00294 (1/1) pfkB family carbohydrate kinase
PF00005 (1/1) ABC transporter

GCF_000721495.1

390.00 +- 216.67

0.01 +- 0.01

PF13620 (1/2) Carboxypeptidase regulatory-like domain
PF07690 (1/2) Major Facilitator Superfamily
PF01988 (1/2) VIT family
PF01344 (1/2) Kelch motif
PF01169 (1/2) Uncharacterized protein family UPF0016
PF01012 (1/2) Electron transfer flavoprotein domain
PF00766 (1/2) Electron transfer flavoprotein FAD-binding domain
PF00553 (1/2) Cellulose binding domain
PF00196 (1/2) Bacterial regulatory proteins, luxR family
PF00150 (1/2) Cellulase (glycosyl hydrolase family 5)

GCF_000717745.1

658.67 +- 485.33

0.04 +- 0.04

TIGR00710 (1/2) drug resistance transporter, Bcr/CflA subfamily
PF07690 (1/2) Major Facilitator Superfamily
PF03807 (1/2) NADP oxidoreductase coenzyme F420-dependent
PF03737 (1/2) Aldolase/RraA
PF03466 (1/2) LysR substrate binding domain
PF01814 (1/2) Hemerythrin HHE cation binding domain
PF01408 (1/2) Oxidoreductase family, NAD-binding Rossmann fold
PF01361 (1/2) Tautomerase enzyme
PF00994 (1/2) Probable molybdopterin binding domain
PF00890 (1/2) FAD binding domain
PF00881 (1/2) Nitroreductase family
PF00682 (1/2) HMGL-like
PF00440 (1/2) Bacterial regulatory proteins, tetR family
PF00180 (1/2) Isocitrate/isopropylmalate dehydrogenase
PF00126 (1/2) Bacterial regulatory helix-turn-helix protein, lysR family

GCF_000403765.2

501.22 +- 712.73

0.02 +- 0.05

No common domains found

GCF_003116725.1

60.67 +- 17.33

0.04 +- 0.05

PF17866 (1/2) AAA lid domain
PF13229 (1/2) Right handed beta helix region
PF07504 (1/2) Fungalysin/Thermolysin Propeptide Motif
PF05345 (1/2) Putative Ig domain
PF02868 (1/2) Thermolysin metallopeptidase, alpha-helical domain
PF01636 (1/2) Phosphotransferase enzyme family
PF01447 (1/2) Thermolysin metallopeptidase, catalytic domain
PF00652 (1/2) Ricin-type beta-trefoil lectin domain
PF00082 (1/2) Subtilase family
PF00004 (1/2) ATPase family associated with various cellular activities (AAA)

GCF_001434355.1

107.32 +- 81.88

0.04 +- 0.08

TIGR03920 (1/2) type VII secretion integral membrane protein EccD
TIGR03919 (1/2) type VII secretion protein EccB
TIGR03696 (1/2) RHS repeat-associated core domain
TIGR01643 (1/2) YD repeat (two copies)
PF08817 (1/2) WXG100 protein secretion system (Wss), protein YukD
PF08031 (1/2) Berberine and berberine like
PF07179 (1/2) SseB protein N-terminal domain
PF05593 (1/2) RHS Repeat
PF05108 (1/2) Type VII secretion system ESX-1, transport TM domain B
PF04488 (1/2) Glycosyltransferase sugar-binding region containing DXD motif
PF03527 (1/2) RHS protein
PF02575 (1/2) YbaB/EbfC DNA-binding family
PF01565 (1/2) FAD binding domain
PF00293 (1/2) NUDIX domain

GCF_001693675.1

239.77 +- 211.73

0.03 +- 0.06

GCF_001906585.1

204.63 +- 0.00

0.07 +- 0.09

TIGR03892 (1/1) thiazolylpeptide-type bacteriocin precursor
TIGR03882 (1/1) bacteriocin biosynthesis cyclodehydratase domain
TIGR03604 (1/1) thiazole/oxazole-forming peptide maturase, SagD family component
TIGR01891 (1/1) amidohydrolase
TIGR01552 (1/1) prevent-host-death family protein
PF14028 (1/1) Lantibiotic biosynthesis dehydratase C-term
PF04738 (1/1) Lantibiotic dehydratase, N terminus
PF03704 (1/1) Bacterial transcriptional activator domain
PF02624 (1/1) YcaO cyclodehydratase, ATP-ad Mg2+-binding
PF02604 (1/1) Antitoxin Phd_YefM, type II toxin-antitoxin system
PF01850 (1/1) PIN domain
PF01546 (1/1) Peptidase family M20/M25/M40
PF01061 (1/1) ABC-2 type transporter
PF00881 (1/1) Nitroreductase family
PF00582 (1/1) Universal stress protein family
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00005 (1/1) ABC transporter

GCF_003574445.1

328.14 +- 84.39

0.03 +- 0.04

TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
TIGR00738 (1/2) Rrf2 family protein
PF18364 (1/2) Molybdopterin oxidoreductase N-terminal domain
PF13743 (1/2) Thioredoxin
PF13561 (1/2) Enoyl-(Acyl carrier protein) reductase
PF13427 (1/2) Domain of unknown function (DUF4111)
PF12146 (1/2) Serine aminopeptidase, S33
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF08028 (1/2) Acyl-CoA dehydrogenase, C-terminal domain
PF07690 (1/2) Major Facilitator Superfamily
PF04309 (1/2) Glycerol-3-phosphate responsive antiterminator
PF02913 (1/2) FAD linked oxidases, C-terminal domain
PF02782 (1/2) FGGY family of carbohydrate kinases, C-terminal domain
PF02771 (1/2) Acyl-CoA dehydrogenase, N-terminal domain
PF02770 (1/2) Acyl-CoA dehydrogenase, middle domain
PF02082 (1/2) Transcriptional regulator
PF01909 (1/2) Nucleotidyltransferase domain
PF01613 (1/2) Flavin reductase like domain
PF01568 (1/2) Molydopterin dinucleotide binding domain
PF01565 (1/2) FAD binding domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00384 (1/2) Molybdopterin oxidoreductase
PF00370 (1/2) FGGY family of carbohydrate kinases, N-terminal domain
PF00296 (1/2) Luciferase-like monooxygenase
PF00005 (1/2) ABC transporter

GCF_001279365.1

162.04 +- 97.96

0.05 +- 0.04

TIGR03945 (1/2) 2,3-diaminopropionate biosynthesis protein SbnA
TIGR03944 (1/2) 2,3-diaminopropionate biosynthesis protein SbnB
TIGR01891 (1/2) amidohydrolase
TIGR00843 (1/2) benzoate transporter
PF13454 (1/2) FAD-NAD(P)-binding
PF13424 (1/2) Tetratricopeptide repeat
PF03594 (1/2) Benzoate membrane transport protein
PF03412 (1/2) Peptidase C39 family
PF02423 (1/2) Ornithine cyclodeaminase/mu-crystallin family
PF01546 (1/2) Peptidase family M20/M25/M40
PF01053 (1/2) Cys/Met metabolism PLP-dependent enzyme
PF00931 (1/2) NB-ARC domain
PF00664 (1/2) ABC transporter transmembrane region
PF00535 (1/2) Glycosyl transferase family 2
PF00291 (1/2) Pyridoxal-phosphate dependent enzyme
PF00005 (1/2) ABC transporter

GCF_004117935.1

37.68 +- 12.32

0.06 +- 0.09

PF13673 (1/2) Acetyltransferase (GNAT) domain
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF05977 (1/2) Transmembrane secretion effector
PF05013 (1/2) N-formylglutamate amidohydrolase
PF02225 (1/2) PA domain
PF00248 (1/2) Aldo/keto reductase family
PF00082 (1/2) Subtilase family
PF00069 (1/2) Protein kinase domain

GCF_900206255.1

176.37 +- 179.33

0.05 +- 0.04

No common domains found

GCF_000177175.2

1219.64 +- 0.00

0.01 +- 0.00

TIGR01727 (1/1) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17645 (1/1) Arylmalonate decarboxylase
PF13489 (1/1) Methyltransferase domain
PF09339 (1/1) IclR helix-turn-helix domain
PF08352 (1/1) Oligopeptide/dipeptide transporter, C-terminal region
PF04978 (1/1) Protein of unknown function (DUF664)
PF02426 (1/1) Muconolactone delta-isomerase
PF01614 (1/1) Bacterial transcriptional regulator
PF01593 (1/1) Flavin containing amine oxidoreductase
PF01244 (1/1) Membrane dipeptidase (Peptidase family M19)
PF00528 (1/1) Binding-protein-dependent transport system inner membrane component
PF00496 (1/1) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00171 (1/1) Aldehyde dehydrogenase family
PF00005 (1/1) ABC transporter

GCF_002899455.1

61.43 +- 0.00

0.07 +- 0.11

TIGR01733 (1/1) amino acid adenylation domain
TIGR01720 (1/1) non-ribosomal peptide synthase domain TIGR01720
TIGR01263 (1/1) 4-hydroxyphenylpyruvate dioxygenase
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF08242 (1/1) Methyltransferase domain
PF03621 (1/1) MbtH-like protein
PF01070 (1/1) FMN-dependent dehydrogenase
PF00975 (1/1) Thioesterase domain
PF00903 (1/1) Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
PF00668 (1/1) Condensation domain
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00155 (1/1) Aminotransferase class I and II

GCF_001905505.1

34.67 +- 0.00

0.06 +- 0.04

PF09995 (1/1) Uncharacterized protein conserved in bacteria (DUF2236)
PF00171 (1/1) Aldehyde dehydrogenase family

GCF_002154375.1

154.80 +- 0.00

0.09 +- 0.20

TIGR03696 (1/1) RHS repeat-associated core domain
TIGR03494 (1/1) salicylate synthase
TIGR02185 (1/1) putative ECF transporter S component, Trep_Strep family
TIGR01733 (1/1) amino acid adenylation domain
TIGR01643 (1/1) YD repeat (two copies)
TIGR01443 (1/1) intein C-terminal splicing region
PF13193 (1/1) AMP-binding enzyme C-terminal domain
PF09605 (1/1) Hypothetical bacterial integral membrane protein (Trep_Strep)
PF07591 (1/1) Pretoxin HINT domain
PF05593 (1/1) RHS Repeat
PF03704 (1/1) Bacterial transcriptional activator domain
PF02361 (1/1) Cobalt transport protein
PF00975 (1/1) Thioesterase domain
PF00931 (1/1) NB-ARC domain
PF00668 (1/1) Condensation domain
PF00664 (1/1) ABC transporter transmembrane region
PF00550 (1/1) Phosphopantetheine attachment site
PF00501 (1/1) AMP-binding enzyme
PF00486 (1/1) Transcriptional regulatory protein, C terminal
PF00425 (1/1) chorismate binding enzyme
PF00005 (1/1) ABC transporter

GCF_000373665.1

109.42 +- 37.43

0.05 +- 0.11

No common domains found

GCF_001279765.1

1935.00 +- 0.00

0.01 +- 0.00

GCF_003046555.1

3776.18 +- 2873.18

0.01 +- 0.01

PF01381 (2/2) Helix-turn-helix
TIGR03083 (1/2) uncharacterized Actinobacterial protein TIGR03083
TIGR01928 (1/2) o-succinylbenzoate synthase
TIGR01727 (1/2) oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain
PF17964 (1/2) Bacterial Ig domain
PF17853 (1/2) GGDEF-like domain
PF13556 (1/2) PucR C-terminal helix-turn-helix domain
PF13378 (1/2) Enolase C-terminal domain-like
PF11716 (1/2) Mycothiol maleylpyruvate isomerase N-terminal domain
PF10400 (1/2) Virulence activator alpha C-term
PF08667 (1/2) BetR domain
PF08352 (1/2) Oligopeptide/dipeptide transporter, C-terminal region
PF07702 (1/2) UTRA domain
PF07676 (1/2) WD40-like Beta Propeller Repeat
PF07398 (1/2) MDMPI C-terminal domain
PF03734 (1/2) L,D-transpeptidase catalytic domain
PF03551 (1/2) Transcriptional regulator PadR-like family
PF02746 (1/2) Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
PF02687 (1/2) FtsX-like permease family
PF01546 (1/2) Peptidase family M20/M25/M40
PF00931 (1/2) NB-ARC domain
PF00528 (1/2) Binding-protein-dependent transport system inner membrane component
PF00496 (1/2) Bacterial extracellular solute-binding proteins, family 5 Middle
PF00392 (1/2) Bacterial regulatory proteins, gntR family
PF00326 (1/2) Prolyl oligopeptidase family
PF00144 (1/2) Beta-lactamase
PF00005 (1/2) ABC transporter

GCF_004125245.1

167.74 +- 0.00

0.05 +- 0.05

PF16859 (1/1) Tetracyclin repressor-like, C-terminal domain
PF03992 (1/1) Antibiotic biosynthesis monooxygenase
PF00664 (1/1) ABC transporter transmembrane region
PF00440 (1/1) Bacterial regulatory proteins, tetR family
PF00248 (1/1) Aldo/keto reductase family
PF00005 (1/1) ABC transporter

GCF_000746395.1

387.85 +- 395.48

0.03 +- 0.04

No common domains found

GCF_001279375.1

69.28 +- 38.00

0.08 +- 0.08

No common domains found

GCF_900105605.1

463.33 +- 499.87

0.04 +- 0.14

PF12728 (2/3) Helix-turn-helix domain